US20030199699A1 - 3-(4,5-Dihydroisoxaxol-5-yl)benzoylcyclohexenones and the use thereof as herbicides - Google Patents
3-(4,5-Dihydroisoxaxol-5-yl)benzoylcyclohexenones and the use thereof as herbicides Download PDFInfo
- Publication number
- US20030199699A1 US20030199699A1 US10/276,225 US27622502A US2003199699A1 US 20030199699 A1 US20030199699 A1 US 20030199699A1 US 27622502 A US27622502 A US 27622502A US 2003199699 A1 US2003199699 A1 US 2003199699A1
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- US
- United States
- Prior art keywords
- alkyl
- compounds
- alkoxy
- methyl
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000004009 herbicide Substances 0.000 title claims description 7
- 150000001875 compounds Chemical class 0.000 claims abstract description 551
- 239000001257 hydrogen Substances 0.000 claims abstract description 85
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 85
- 229910052736 halogen Inorganic materials 0.000 claims abstract description 69
- 150000002367 halogens Chemical group 0.000 claims abstract description 69
- 125000004093 cyano group Chemical group *C#N 0.000 claims abstract description 54
- RCUGMJIOZITJFH-UHFFFAOYSA-N 2-[3-(4,5-dihydro-1,2-oxazol-5-yl)benzoyl]cyclohex-2-en-1-one Chemical class C=1C=CC(C2ON=CC2)=CC=1C(=O)C1=CCCCC1=O RCUGMJIOZITJFH-UHFFFAOYSA-N 0.000 claims abstract description 38
- 150000002431 hydrogen Chemical group 0.000 claims abstract description 37
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims abstract description 36
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract description 31
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 31
- 238000000034 method Methods 0.000 claims abstract description 21
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 17
- 150000003839 salts Chemical class 0.000 claims abstract description 16
- 125000004741 (C1-C6) haloalkylsulfonyl group Chemical group 0.000 claims abstract description 14
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims abstract description 10
- 125000003545 alkoxy group Chemical group 0.000 claims abstract description 9
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 6
- FWFSEYBSWVRWGL-UHFFFAOYSA-N cyclohex-2-enone Chemical class O=C1CCCC=C1 FWFSEYBSWVRWGL-UHFFFAOYSA-N 0.000 claims abstract description 6
- -1 C1-C4-cyanoalkyl Chemical group 0.000 claims description 1063
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 303
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 105
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 63
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims description 51
- 239000000203 mixture Substances 0.000 claims description 48
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims description 46
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 44
- 125000001424 substituent group Chemical group 0.000 claims description 40
- 125000004767 (C1-C4) haloalkoxy group Chemical group 0.000 claims description 31
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 31
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 27
- 229910052760 oxygen Inorganic materials 0.000 claims description 27
- 239000001301 oxygen Substances 0.000 claims description 27
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 claims description 21
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 20
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims description 18
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 18
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 claims description 16
- 125000000623 heterocyclic group Chemical group 0.000 claims description 16
- 230000008569 process Effects 0.000 claims description 16
- 125000004738 (C1-C6) alkyl sulfinyl group Chemical group 0.000 claims description 15
- 230000002363 herbicidal effect Effects 0.000 claims description 15
- 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 claims description 14
- 125000006771 (C1-C6) haloalkylthio group Chemical group 0.000 claims description 14
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 14
- 125000004749 (C1-C6) haloalkylsulfinyl group Chemical group 0.000 claims description 12
- 238000002360 preparation method Methods 0.000 claims description 10
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims description 9
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims description 9
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 9
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims description 8
- 229910052757 nitrogen Inorganic materials 0.000 claims description 8
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims description 7
- 125000004430 oxygen atom Chemical group O* 0.000 claims description 7
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims description 5
- 238000009472 formulation Methods 0.000 claims description 5
- 150000002829 nitrogen Chemical class 0.000 claims description 5
- 125000006678 phenoxycarbonyl group Chemical group 0.000 claims description 5
- 239000002671 adjuvant Substances 0.000 claims description 4
- 239000003054 catalyst Substances 0.000 claims description 4
- 238000005917 acylation reaction Methods 0.000 claims description 3
- 125000004682 aminothiocarbonyl group Chemical group NC(=S)* 0.000 claims description 3
- 230000002140 halogenating effect Effects 0.000 claims description 3
- 125000006517 heterocyclyl carbonyl group Chemical group 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 239000007800 oxidant agent Substances 0.000 claims description 3
- 238000006462 rearrangement reaction Methods 0.000 claims description 3
- PXQLVRUNWNTZOS-UHFFFAOYSA-N sulfanyl Chemical group [SH] PXQLVRUNWNTZOS-UHFFFAOYSA-N 0.000 claims description 3
- 230000010933 acylation Effects 0.000 claims description 2
- 230000001590 oxidative effect Effects 0.000 claims description 2
- 239000000126 substance Substances 0.000 claims description 2
- RZEALJQFEAUENB-UHFFFAOYSA-N 2-[3-(4,5-dihydro-1,2-oxazol-3-yl)benzoyl]cyclohex-2-en-1-one Chemical compound C=1C=CC(C=2CCON=2)=CC=1C(=O)C1=CCCCC1=O RZEALJQFEAUENB-UHFFFAOYSA-N 0.000 claims 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract description 6
- 125000004663 dialkyl amino group Chemical group 0.000 abstract description 4
- 125000001188 haloalkyl group Chemical group 0.000 abstract description 3
- 125000004644 alkyl sulfinyl group Chemical group 0.000 abstract description 2
- 125000004438 haloalkoxy group Chemical group 0.000 abstract description 2
- 125000004440 haloalkylsulfinyl group Chemical group 0.000 abstract description 2
- 125000004995 haloalkylthio group Chemical group 0.000 abstract description 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- 0 [1*]C1=C(C2([4*])ON=C([7*])C2([5*])[6*])C([2*])=C([3*])C=C1C([11*])=O Chemical compound [1*]C1=C(C2([4*])ON=C([7*])C2([5*])[6*])C([2*])=C([3*])C=C1C([11*])=O 0.000 description 214
- 239000000460 chlorine Substances 0.000 description 155
- 229910052801 chlorine Inorganic materials 0.000 description 79
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 66
- 125000001309 chloro group Chemical group Cl* 0.000 description 55
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 55
- 125000006125 ethylsulfonyl group Chemical group 0.000 description 54
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 45
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 33
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 33
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 27
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 24
- 125000002816 methylsulfanyl group Chemical group [H]C([H])([H])S[*] 0.000 description 24
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 23
- 125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 description 23
- 239000004480 active ingredient Substances 0.000 description 22
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 22
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 21
- 239000002904 solvent Substances 0.000 description 20
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 19
- 229910052794 bromium Inorganic materials 0.000 description 19
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 18
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 18
- 241000196324 Embryophyta Species 0.000 description 16
- 239000002585 base Substances 0.000 description 16
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 15
- 239000000243 solution Substances 0.000 description 15
- 150000002148 esters Chemical class 0.000 description 13
- 238000006243 chemical reaction Methods 0.000 description 12
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 11
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 11
- 150000003254 radicals Chemical class 0.000 description 11
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 10
- MVPPADPHJFYWMZ-UHFFFAOYSA-N chlorobenzene Chemical compound ClC1=CC=CC=C1 MVPPADPHJFYWMZ-UHFFFAOYSA-N 0.000 description 10
- JHIVVAPYMSGYDF-UHFFFAOYSA-N cyclohexanone Chemical compound O=C1CCCCC1 JHIVVAPYMSGYDF-UHFFFAOYSA-N 0.000 description 10
- 239000011737 fluorine Substances 0.000 description 10
- 229910052731 fluorine Inorganic materials 0.000 description 10
- 239000003921 oil Substances 0.000 description 10
- 239000000047 product Substances 0.000 description 10
- 239000011541 reaction mixture Substances 0.000 description 10
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 8
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 8
- BZLVMXJERCGZMT-UHFFFAOYSA-N Methyl tert-butyl ether Chemical compound COC(C)(C)C BZLVMXJERCGZMT-UHFFFAOYSA-N 0.000 description 8
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 8
- 244000038559 crop plants Species 0.000 description 8
- 125000003754 ethoxycarbonyl group Chemical group C(=O)(OCC)* 0.000 description 8
- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 description 8
- 125000004769 (C1-C4) alkylsulfonyl group Chemical group 0.000 description 7
- 239000002253 acid Substances 0.000 description 7
- 239000006185 dispersion Substances 0.000 description 7
- 125000001153 fluoro group Chemical group F* 0.000 description 7
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical group II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 7
- 239000007858 starting material Substances 0.000 description 7
- WSLDOOZREJYCGB-UHFFFAOYSA-N 1,2-Dichloroethane Chemical compound ClCCCl WSLDOOZREJYCGB-UHFFFAOYSA-N 0.000 description 6
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 6
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 229910000288 alkali metal carbonate Chemical group 0.000 description 6
- 150000008041 alkali metal carbonates Chemical group 0.000 description 6
- 150000004945 aromatic hydrocarbons Chemical class 0.000 description 6
- 238000009835 boiling Methods 0.000 description 6
- 239000004359 castor oil Substances 0.000 description 6
- 235000019438 castor oil Nutrition 0.000 description 6
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 6
- ORTFAQDWJHRMNX-UHFFFAOYSA-N hydroxidooxidocarbon(.) Chemical group O[C]=O ORTFAQDWJHRMNX-UHFFFAOYSA-N 0.000 description 6
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 6
- 229920006395 saturated elastomer Polymers 0.000 description 6
- 238000011282 treatment Methods 0.000 description 6
- 238000010626 work up procedure Methods 0.000 description 6
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 5
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 5
- 125000003342 alkenyl group Chemical group 0.000 description 5
- 239000012141 concentrate Substances 0.000 description 5
- 239000000839 emulsion Substances 0.000 description 5
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 description 5
- 239000008187 granular material Substances 0.000 description 5
- 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 description 5
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical class C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 5
- 239000003880 polar aprotic solvent Substances 0.000 description 5
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Chemical group COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 5
- 239000011347 resin Substances 0.000 description 5
- 229920005989 resin Polymers 0.000 description 5
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 5
- 239000008096 xylene Substances 0.000 description 5
- 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 description 4
- 125000001541 3-thienyl group Chemical group S1C([H])=C([*])C([H])=C1[H] 0.000 description 4
- VHYFNPMBLIVWCW-UHFFFAOYSA-N 4-Dimethylaminopyridine Chemical compound CN(C)C1=CC=NC=C1 VHYFNPMBLIVWCW-UHFFFAOYSA-N 0.000 description 4
- 240000006122 Chenopodium album Species 0.000 description 4
- 235000009344 Chenopodium album Nutrition 0.000 description 4
- 235000010823 Digitaria sanguinalis Nutrition 0.000 description 4
- 239000013543 active substance Substances 0.000 description 4
- 229910052783 alkali metal Inorganic materials 0.000 description 4
- 125000000304 alkynyl group Chemical group 0.000 description 4
- 150000001735 carboxylic acids Chemical class 0.000 description 4
- 150000008280 chlorinated hydrocarbons Chemical class 0.000 description 4
- 125000001028 difluoromethyl group Chemical group [H]C(F)(F)* 0.000 description 4
- 150000002170 ethers Chemical class 0.000 description 4
- 125000004672 ethylcarbonyl group Chemical group [H]C([H])([H])C([H])([H])C(*)=O 0.000 description 4
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 description 4
- 238000011065 in-situ storage Methods 0.000 description 4
- 235000012054 meals Nutrition 0.000 description 4
- 125000004674 methylcarbonyl group Chemical group CC(=O)* 0.000 description 4
- 150000002825 nitriles Chemical class 0.000 description 4
- MCSAJNNLRCFZED-UHFFFAOYSA-N nitroethane Chemical compound CC[N+]([O-])=O MCSAJNNLRCFZED-UHFFFAOYSA-N 0.000 description 4
- CTSLXHKWHWQRSH-UHFFFAOYSA-N oxalyl chloride Chemical compound ClC(=O)C(Cl)=O CTSLXHKWHWQRSH-UHFFFAOYSA-N 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- 239000000376 reactant Substances 0.000 description 4
- 229910000029 sodium carbonate Inorganic materials 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- DYHSDKLCOJIUFX-UHFFFAOYSA-N tert-butoxycarbonyl anhydride Chemical compound CC(C)(C)OC(=O)OC(=O)OC(C)(C)C DYHSDKLCOJIUFX-UHFFFAOYSA-N 0.000 description 4
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 description 4
- RIOQSEWOXXDEQQ-UHFFFAOYSA-N triphenylphosphine Chemical compound C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-N 0.000 description 4
- 125000002941 2-furyl group Chemical group O1C([*])=C([H])C([H])=C1[H] 0.000 description 3
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 description 3
- 125000000389 2-pyrrolyl group Chemical group [H]N1C([*])=C([H])C([H])=C1[H] 0.000 description 3
- 125000003682 3-furyl group Chemical group O1C([H])=C([*])C([H])=C1[H] 0.000 description 3
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 description 3
- 125000001397 3-pyrrolyl group Chemical group [H]N1C([H])=C([*])C([H])=C1[H] 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 3
- 244000237956 Amaranthus retroflexus Species 0.000 description 3
- 240000003176 Digitaria ciliaris Species 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 3
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- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 3
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- 150000007513 acids Chemical class 0.000 description 3
- 150000003973 alkyl amines Chemical group 0.000 description 3
- 125000005133 alkynyloxy group Chemical group 0.000 description 3
- 150000001450 anions Chemical class 0.000 description 3
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- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 3
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- 229910052500 inorganic mineral Inorganic materials 0.000 description 3
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- 229910000027 potassium carbonate Inorganic materials 0.000 description 3
- 235000011181 potassium carbonates Nutrition 0.000 description 3
- 239000002244 precipitate Substances 0.000 description 3
- 239000012312 sodium hydride Substances 0.000 description 3
- 229910000104 sodium hydride Inorganic materials 0.000 description 3
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- 238000003786 synthesis reaction Methods 0.000 description 3
- LEIMLDGFXIOXMT-UHFFFAOYSA-N trimethylsilyl cyanide Chemical compound C[Si](C)(C)C#N LEIMLDGFXIOXMT-UHFFFAOYSA-N 0.000 description 3
- 125000001305 1,2,4-triazol-3-yl group Chemical group [H]N1N=C([*])N=C1[H] 0.000 description 2
- 125000004317 1,3,5-triazin-2-yl group Chemical group [H]C1=NC(*)=NC([H])=N1 0.000 description 2
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- LCDUHTMLRVPUNT-UHFFFAOYSA-N 2-methyl-3-(3-methyl-4,5-dihydro-1,2-oxazol-5-yl)-4-methylsulfonylbenzoic acid Chemical compound C1C(C)=NOC1C1=C(C)C(C(O)=O)=CC=C1S(C)(=O)=O LCDUHTMLRVPUNT-UHFFFAOYSA-N 0.000 description 2
- BTOJSYRZQZOMOK-UHFFFAOYSA-N 4-chloro-7-(4-methylphenyl)sulfonylpyrrolo[2,3-d]pyrimidine Chemical compound C1=CC(C)=CC=C1S(=O)(=O)N1C2=NC=NC(Cl)=C2C=C1 BTOJSYRZQZOMOK-UHFFFAOYSA-N 0.000 description 2
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 description 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 2
- 239000005995 Aluminium silicate Substances 0.000 description 2
- 235000013479 Amaranthus retroflexus Nutrition 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 2
- 235000021533 Beta vulgaris Nutrition 0.000 description 2
- 241000335053 Beta vulgaris Species 0.000 description 2
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- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 description 1
- 125000004983 dialkoxyalkyl group Chemical group 0.000 description 1
- 125000004985 dialkyl amino alkyl group Chemical group 0.000 description 1
- 125000004473 dialkylaminocarbonyl group Chemical group 0.000 description 1
- MNNHAPBLZZVQHP-UHFFFAOYSA-N diammonium hydrogen phosphate Chemical compound [NH4+].[NH4+].OP([O-])([O-])=O MNNHAPBLZZVQHP-UHFFFAOYSA-N 0.000 description 1
- 150000004891 diazines Chemical class 0.000 description 1
- 125000004774 dichlorofluoromethyl group Chemical group FC(Cl)(Cl)* 0.000 description 1
- 125000004772 dichloromethyl group Chemical group [H]C(Cl)(Cl)* 0.000 description 1
- 239000002283 diesel fuel Substances 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 125000001664 diethylamino group Chemical group [H]C([H])([H])C([H])([H])N(*)C([H])([H])C([H])([H])[H] 0.000 description 1
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 1
- 125000004786 difluoromethoxy group Chemical group [H]C(F)(F)O* 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-M dihydrogenphosphate Chemical compound OP(O)([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-M 0.000 description 1
- UAOMVDZJSHZZME-UHFFFAOYSA-N diisopropylamine Chemical compound CC(C)NC(C)C UAOMVDZJSHZZME-UHFFFAOYSA-N 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 description 1
- USIUVYZYUHIAEV-UHFFFAOYSA-N diphenyl ether Chemical class C=1C=CC=CC=1OC1=CC=CC=C1 USIUVYZYUHIAEV-UHFFFAOYSA-N 0.000 description 1
- LQZZUXJYWNFBMV-UHFFFAOYSA-N dodecan-1-ol Chemical compound CCCCCCCCCCCCO LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 description 1
- 239000010459 dolomite Substances 0.000 description 1
- 229910000514 dolomite Inorganic materials 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 238000010410 dusting Methods 0.000 description 1
- 229940052303 ethers for general anesthesia Drugs 0.000 description 1
- 125000005745 ethoxymethyl group Chemical group [H]C([H])([H])C([H])([H])OC([H])([H])* 0.000 description 1
- HNEFRFQKSXMEBH-UHFFFAOYSA-N ethyl 5-(2-chloro-3-methoxycarbonyl-6-methylsulfonylphenyl)-4,5-dihydro-1,2-oxazole-3-carboxylate Chemical compound C1C(C(=O)OCC)=NOC1C1=C(Cl)C(C(=O)OC)=CC=C1S(C)(=O)=O HNEFRFQKSXMEBH-UHFFFAOYSA-N 0.000 description 1
- 125000000031 ethylamino group Chemical group [H]C([H])([H])C([H])([H])N([H])[*] 0.000 description 1
- 125000006351 ethylthiomethyl group Chemical group [H]C([H])([H])C([H])([H])SC([H])([H])* 0.000 description 1
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 239000003337 fertilizer Substances 0.000 description 1
- 235000004426 flaxseed Nutrition 0.000 description 1
- VUWZPRWSIVNGKG-UHFFFAOYSA-N fluoromethane Chemical compound F[CH2] VUWZPRWSIVNGKG-UHFFFAOYSA-N 0.000 description 1
- 125000004785 fluoromethoxy group Chemical group [H]C([H])(F)O* 0.000 description 1
- 125000004216 fluoromethyl group Chemical group [H]C([H])(F)* 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 235000002532 grape seed extract Nutrition 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 239000003630 growth substance Substances 0.000 description 1
- 150000004820 halides Chemical class 0.000 description 1
- 125000000262 haloalkenyl group Chemical group 0.000 description 1
- 125000004993 haloalkoxycarbonyl group Chemical group 0.000 description 1
- 125000004692 haloalkylcarbonyl group Chemical group 0.000 description 1
- 125000004441 haloalkylsulfonyl group Chemical group 0.000 description 1
- 150000003977 halocarboxylic acids Chemical class 0.000 description 1
- 150000002366 halogen compounds Chemical class 0.000 description 1
- 125000006343 heptafluoro propyl group Chemical group 0.000 description 1
- 125000003187 heptyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000004415 heterocyclylalkyl group Chemical group 0.000 description 1
- 150000004761 hexafluorosilicates Chemical class 0.000 description 1
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 239000003864 humus Substances 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-M hydrogensulfate Chemical compound OS([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-M 0.000 description 1
- 230000003301 hydrolyzing effect Effects 0.000 description 1
- 150000002460 imidazoles Chemical class 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
- 125000004491 isohexyl group Chemical group C(CCC(C)C)* 0.000 description 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
- 125000001972 isopentyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000001793 isothiazol-3-yl group Chemical group [H]C1=C([H])C(*)=NS1 0.000 description 1
- 125000004500 isothiazol-4-yl group Chemical group S1N=CC(=C1)* 0.000 description 1
- 125000004501 isothiazol-5-yl group Chemical group S1N=CC=C1* 0.000 description 1
- 239000003350 kerosene Substances 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 239000004571 lime Substances 0.000 description 1
- 239000006028 limestone Substances 0.000 description 1
- 229910052744 lithium Inorganic materials 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000000395 magnesium oxide Substances 0.000 description 1
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 1
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 1
- 235000019341 magnesium sulphate Nutrition 0.000 description 1
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 description 1
- 235000009973 maize Nutrition 0.000 description 1
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 description 1
- 125000002960 margaryl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- VUZPPFZMUPKLLV-UHFFFAOYSA-N methane;hydrate Chemical compound C.O VUZPPFZMUPKLLV-UHFFFAOYSA-N 0.000 description 1
- QARBMVPHQWIHKH-UHFFFAOYSA-N methanesulfonyl chloride Chemical compound CS(Cl)(=O)=O QARBMVPHQWIHKH-UHFFFAOYSA-N 0.000 description 1
- 125000004184 methoxymethyl group Chemical group [H]C([H])([H])OC([H])([H])* 0.000 description 1
- GJSCZAHOINTRHP-UHFFFAOYSA-N methyl 2,4-dichloro-3-ethenylbenzoate Chemical compound COC(=O)C1=CC=C(Cl)C(C=C)=C1Cl GJSCZAHOINTRHP-UHFFFAOYSA-N 0.000 description 1
- DKNDWMVQSHXYPN-UHFFFAOYSA-N methyl 3-(3-tert-butyl-4,5-dihydro-1,2-oxazol-5-yl)-2,4-dichlorobenzoate Chemical compound COC(=O)C1=CC=C(Cl)C(C2ON=C(C2)C(C)(C)C)=C1Cl DKNDWMVQSHXYPN-UHFFFAOYSA-N 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 description 1
- 125000004092 methylthiomethyl group Chemical group [H]C([H])([H])SC([H])([H])* 0.000 description 1
- 239000012452 mother liquor Substances 0.000 description 1
- OEFVJAZWSLPDEP-UHFFFAOYSA-N n-(2,2-dimethylpropylidene)hydroxylamine Chemical compound CC(C)(C)C=NO OEFVJAZWSLPDEP-UHFFFAOYSA-N 0.000 description 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- WNPVAXLJVUXYFU-UHFFFAOYSA-N n-cyclohex-2-en-1-ylidenehydroxylamine Chemical compound ON=C1CCCC=C1 WNPVAXLJVUXYFU-UHFFFAOYSA-N 0.000 description 1
- 125000001280 n-hexyl group Chemical group C(CCCCC)* 0.000 description 1
- PSZYNBSKGUBXEH-UHFFFAOYSA-N naphthalene-1-sulfonic acid Chemical class C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1 PSZYNBSKGUBXEH-UHFFFAOYSA-N 0.000 description 1
- 125000001971 neopentyl group Chemical group [H]C([*])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 229910052759 nickel Inorganic materials 0.000 description 1
- 125000004971 nitroalkyl group Chemical group 0.000 description 1
- 125000005246 nonafluorobutyl group Chemical group FC(F)(F)C(F)(F)C(F)(F)C(F)(F)* 0.000 description 1
- 239000012875 nonionic emulsifier Substances 0.000 description 1
- 231100001184 nonphytotoxic Toxicity 0.000 description 1
- SNQQPOLDUKLAAF-UHFFFAOYSA-N nonylphenol Chemical compound CCCCCCCCCC1=CC=CC=C1O SNQQPOLDUKLAAF-UHFFFAOYSA-N 0.000 description 1
- 238000000655 nuclear magnetic resonance spectrum Methods 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 150000004866 oxadiazoles Chemical class 0.000 description 1
- 150000002923 oximes Chemical class 0.000 description 1
- 150000002924 oxiranes Chemical class 0.000 description 1
- 229910052763 palladium Inorganic materials 0.000 description 1
- YJVFFLUZDVXJQI-UHFFFAOYSA-L palladium(ii) acetate Chemical compound [Pd+2].CC([O-])=O.CC([O-])=O YJVFFLUZDVXJQI-UHFFFAOYSA-L 0.000 description 1
- 125000002958 pentadecyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000003538 pentan-3-yl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000002409 penten-3-yl group Chemical group C=CC(CC)* 0.000 description 1
- 125000002262 penten-4-yl group Chemical group C=CCC(C)* 0.000 description 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
- 125000001148 pentyloxycarbonyl group Chemical group 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 description 1
- 229960003424 phenylacetic acid Drugs 0.000 description 1
- 239000003279 phenylacetic acid Substances 0.000 description 1
- 125000003884 phenylalkyl group Chemical group 0.000 description 1
- 150000008048 phenylpyrazoles Chemical class 0.000 description 1
- UXCDUFKZSUBXGM-UHFFFAOYSA-N phosphoric tribromide Chemical compound BrP(Br)(Br)=O UXCDUFKZSUBXGM-UHFFFAOYSA-N 0.000 description 1
- UHZYTMXLRWXGPK-UHFFFAOYSA-N phosphorus pentachloride Chemical compound ClP(Cl)(Cl)(Cl)Cl UHZYTMXLRWXGPK-UHFFFAOYSA-N 0.000 description 1
- 230000003032 phytopathogenic effect Effects 0.000 description 1
- SIOXPEMLGUPBBT-UHFFFAOYSA-N picolinic acid Chemical compound OC(=O)C1=CC=CC=N1 SIOXPEMLGUPBBT-UHFFFAOYSA-N 0.000 description 1
- 125000004574 piperidin-2-yl group Chemical group N1C(CCCC1)* 0.000 description 1
- 125000004483 piperidin-3-yl group Chemical group N1CC(CCC1)* 0.000 description 1
- 125000004482 piperidin-4-yl group Chemical group N1CCC(CC1)* 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 239000002798 polar solvent Substances 0.000 description 1
- 229920000570 polyether Polymers 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 229960003975 potassium Drugs 0.000 description 1
- 229910000028 potassium bicarbonate Inorganic materials 0.000 description 1
- 235000015497 potassium bicarbonate Nutrition 0.000 description 1
- 239000011736 potassium bicarbonate Substances 0.000 description 1
- NNFCIKHAZHQZJG-UHFFFAOYSA-N potassium cyanide Chemical compound [K+].N#[C-] NNFCIKHAZHQZJG-UHFFFAOYSA-N 0.000 description 1
- 229940086066 potassium hydrogencarbonate Drugs 0.000 description 1
- 125000001844 prenyl group Chemical group [H]C([*])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 125000006238 prop-1-en-1-yl group Chemical group [H]\C(*)=C(/[H])C([H])([H])[H] 0.000 description 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
- 125000005767 propoxymethyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])[#8]C([H])([H])* 0.000 description 1
- 125000004742 propyloxycarbonyl group Chemical group 0.000 description 1
- 239000011814 protection agent Substances 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 150000003217 pyrazoles Chemical class 0.000 description 1
- 125000002206 pyridazin-3-yl group Chemical group [H]C1=C([H])C([H])=C(*)N=N1 0.000 description 1
- 125000004940 pyridazin-4-yl group Chemical group N1=NC=C(C=C1)* 0.000 description 1
- 150000004892 pyridazines Chemical class 0.000 description 1
- LOAUVZALPPNFOQ-UHFFFAOYSA-N quinaldic acid Chemical compound C1=CC=CC2=NC(C(=O)O)=CC=C21 LOAUVZALPPNFOQ-UHFFFAOYSA-N 0.000 description 1
- 238000010188 recombinant method Methods 0.000 description 1
- 235000013526 red clover Nutrition 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 229910052703 rhodium Inorganic materials 0.000 description 1
- 239000010948 rhodium Substances 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 239000012266 salt solution Substances 0.000 description 1
- 239000004576 sand Substances 0.000 description 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 125000003548 sec-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 150000004760 silicates Chemical class 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- QDRKDTQENPPHOJ-UHFFFAOYSA-N sodium ethoxide Chemical compound [Na+].CC[O-] QDRKDTQENPPHOJ-UHFFFAOYSA-N 0.000 description 1
- SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 description 1
- PYODKQIVQIVELM-UHFFFAOYSA-M sodium;2,3-bis(2-methylpropyl)naphthalene-1-sulfonate Chemical compound [Na+].C1=CC=C2C(S([O-])(=O)=O)=C(CC(C)C)C(CC(C)C)=CC2=C1 PYODKQIVQIVELM-UHFFFAOYSA-M 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 229940124530 sulfonamide Drugs 0.000 description 1
- 150000003456 sulfonamides Chemical class 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 150000003460 sulfonic acids Chemical class 0.000 description 1
- RWSOTUBLDIXVET-UHFFFAOYSA-O sulfonium Chemical compound [SH3+] RWSOTUBLDIXVET-UHFFFAOYSA-O 0.000 description 1
- 150000003461 sulfonyl halides Chemical class 0.000 description 1
- 125000005537 sulfoxonium group Chemical group 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 229920002994 synthetic fiber Polymers 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 125000001973 tert-pentyl group Chemical group [H]C([H])([H])C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 150000003512 tertiary amines Chemical class 0.000 description 1
- DZLFLBLQUQXARW-UHFFFAOYSA-N tetrabutylammonium Chemical compound CCCC[N+](CCCC)(CCCC)CCCC DZLFLBLQUQXARW-UHFFFAOYSA-N 0.000 description 1
- 125000004192 tetrahydrofuran-2-yl group Chemical group [H]C1([H])OC([H])(*)C([H])([H])C1([H])[H] 0.000 description 1
- 125000004187 tetrahydropyran-2-yl group Chemical group [H]C1([H])OC([H])(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
- 125000004297 tetrahydropyrrol-2-yl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])([H])C1([H])* 0.000 description 1
- CXWXQJXEFPUFDZ-UHFFFAOYSA-N tetralin Chemical compound C1=CC=C2CCCCC2=C1 CXWXQJXEFPUFDZ-UHFFFAOYSA-N 0.000 description 1
- QEMXHQIAXOOASZ-UHFFFAOYSA-N tetramethylammonium Chemical compound C[N+](C)(C)C QEMXHQIAXOOASZ-UHFFFAOYSA-N 0.000 description 1
- 125000000383 tetramethylene group Chemical group [H]C([H])([*:1])C([H])([H])C([H])([H])C([H])([H])[*:2] 0.000 description 1
- 125000004299 tetrazol-5-yl group Chemical group [H]N1N=NC(*)=N1 0.000 description 1
- 125000003396 thiol group Chemical group [H]S* 0.000 description 1
- HFRXJVQOXRXOPP-UHFFFAOYSA-N thionyl bromide Chemical compound BrS(Br)=O HFRXJVQOXRXOPP-UHFFFAOYSA-N 0.000 description 1
- 150000003624 transition metals Chemical class 0.000 description 1
- 150000003918 triazines Chemical class 0.000 description 1
- 125000003866 trichloromethyl group Chemical group ClC(Cl)(Cl)* 0.000 description 1
- WLPUWLXVBWGYMZ-UHFFFAOYSA-N tricyclohexylphosphine Chemical compound C1CCCCC1P(C1CCCCC1)C1CCCCC1 WLPUWLXVBWGYMZ-UHFFFAOYSA-N 0.000 description 1
- 125000003258 trimethylene group Chemical group [H]C([H])([*:2])C([H])([H])C([H])([H])[*:1] 0.000 description 1
- PBYZMCDFOULPGH-UHFFFAOYSA-N tungstate Chemical compound [O-][W]([O-])(=O)=O PBYZMCDFOULPGH-UHFFFAOYSA-N 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/04—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
Definitions
- the present invention relates to 3-(4,5-dihydroisoxazol-5-yl)benzoylcyclohexenones of the formula I
- R 1 , R 2 are hydrogen, nitro, halogen, cyano, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 1 -C 6 -alkoxy, C 1 -C 6 -haloalkoxy, C 1 -C 6 -alkylthio, C 1 -C 6 -haloalkylthio, C 1 -C 6 -alkylsulfinyl, C 1 -C 6 -haloalkylsulfinyl, C 1 -C 6 -alkylsulfonyl or C 1 -C 6 -haloalkylsulfonyl;
- R 3 is hydrogen, halogen or C 1 -C 6 -alkyl
- R 4 is hydrogen or C 1 -C 4 -alkyl
- R 5 , R 6 are hydrogen, halogen, cyano, nitro, C 1 -C 4 -alkyl, C 1 -C 4 -alkoxy-C 1 -C 4 -alkyl, di(C 1 -C 4 -alkoxy) -C 1 -C 4 -alkyl, di(C 1 -C 4 -alkyl)amino-C 1 -C 4 -alkyl, di(C 1 -C 4 -alkyl)aminoimino-C 1 -C 4 -alkyl, hydroxyimino-C 1 -C 4 -alkyl, C 1 -C 6 -alkoxyimino-C 1 -C 4 -alkyl, C 1 -C 4 -alkoxycarbonyl-C 1 -C 4 -alkyl, C 1 -C 4 -alkylthio-C 1 -C 4 -alkyl, C 1 -C 4 -alkyl
- R 5 and R 6 together form a C 2 -C 6 -alkanediyl chain which can be mono- to tetrasubstituted by C 1 -C 4 -alkyl and/or can be interrupted by oxygen or by unsubstituted or C 1 -C 4 -alkyl-substituted nitrogen;
- R 7 is halogen, cyano, hydroxyl, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 1 -C 6 -alkoxy, C 1 -C 6 -haloalkoxy, C 1 -C 6 -alkylthio, C 1 -C 6 -haloalkylthio, C 1 -C 6 -alkylsulfinyl, C 1 -C 6 -haloalkylsulfinyl, C 1 -C 6 -alkylsulfonyl, C 1 -C 6 -haloalkylsulfonyl, amino, C 1 -C 6 -alkylamino, di(C 1 -C 6 -alkyl)amino, di(C 1 -C 4 -alkoxy)methyl, hydroxylamino-C 1 -C 4 -alkyl, C 1 -C 6 -alk
- R 8 is hydrogen, C 1 -C 4 -alkyl, C 1 -C 4 -haloalkyl, hydroxyl, C 1 -C 4 -alkoxy, C 1 -C 4 -alkoxy-C 2 -C 4 -alkoxy, C 1 -C 4 -haloalkoxy, C 3 -C 6 -alkenyloxy, C 3 -C 6 -alkynyloxy or NR 9 R 10 ;
- R 9 is hydrogen or C 1 -C 4 -alkyl
- R 10 is C 1 -C 4 -alkyl
- R 11 is a cyclohexenone of the formula II
- R 12 is hydroxyl, mercapto, halogen, OR 19 , SR 19 , SOR 20 or SO 2 R 20 ;
- R 13 , R 17 are hydrogen, C 1 -C 4 -alkyl, C 1 -C 4 -alkylthio or C 1 -C 4 -alkoxycarbonyl;
- R 14 , R 16 , R 18 are hydrogen or C 1 -C 4 -alkyl
- R 15 is hydrogen, hydroxyl, halogen, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, di(C 1 -C 6 -alkoxy)methyl, (C 1 -C 6 -alkoxy) (C 1 -C 6 -alkylthio)methyl, di(C 1 -C 6 -alkylthio)methyl, C 1 -C 6 -alkoxy, C 1 -C 6 -haloalkoxy, C 1 -C 6 -alkylthio, C 1 -C 6 -haloalkylthio, C 1 -C 6 -alkoxycarbonyl, C 1 -C 6 -haloalkoxycarbonyl, 1,3-dioxolan-2-yl, 1,3-dioxan-2-yl, 1,3-oxathiolan-2-yl, 1,3-oxathian-2-yl, 1,3-dithiola
- R 13 and R 14 or R 17 and R 18 together are C 1 -C 5 -alkanediyl which can have attached to it one, two or three substituents selected from amongst halogen, cyano, C 1 -C 4 -alkyl, C 1 -C 4 -haloalkyl or C 1 -C 4 -alkoxycarbonyl;
- R 14 and R 15 or R 15 and R 18 together are a chemical bond or C 1 -C 5 -alkanediyl which can have attached to it one, two or three substituents selected from amongst halogen, cyano, C 1 -C 4 -alkyl, C 1 -C 4 -haloalkyl or C 1 -C 4 -alkoxycarbonyl;
- R 14 and R 18 together are C 1 -C 5 -alkanediyl which can have attached to it one, two or three substituents selected from amongst halogen, cyano, C 1 -C 4 -alkyl, C 1 -C 4 -haloalkyl or C 1 -C 4 -alkoxycarbonyl;
- R 15 and R 16 together are —O—(CH 2 ) p —O—, —O—(CH 2 ) p —S—, —S—(CH 2 ) p —S—, —O—(CH 2 ) q — or —S—(CH 2 ) q —, each of which can have attached to it one, two or three substituents selected from amongst halogen, cyano, C 1 -C 4 -alkyl, C 1 -C 4 -haloalkyl or C 1 -C 4 -alkoxycarbonyl;
- R 15 and R 16 together are an oxygen atom
- R 19 is C 1 -C 6 -alkyl, C 3 -C 6 -alkenyl, C 3 -C 6 -haloalkenyl, C 3 -C 6 -alkynyl, C 3 -C 6 -cycloalkyl, C 1 -C 20 -alkylcarbonyl, C 2 -C 20 -alkenylcarbonyl, C 2 -C 6 -alkynylcarbonyl, C 1 -C 6 -alkoxycarbonyl, C 3 -C 6 -alkenyloxycarbonyl, C 3 -C 6 -alkynyloxycarbonyl, C 1 -C 6 -alkylthiocarbonyl, C 1 -C 6 -alkylaminocarbonyl, C 3 -C 6 -alkenylaminocarbonyl, C 3 -C 6 -alkynylaminocarbonyl, N, N-di(C 1 -
- R 20 is C 1 -C 6 -alkyl, C 3 -C 6 -alkenyl, C 3 -C 6 -haloalkenyl, C 3 -C 6 -alkynyl or C 3 -C 6 -cycloalkyl, it being possible for the abovementioned alkyl and cycloalkyl radicals to be partially or fully halogenated and/or to have attached to them one, two or three substituents selected from amongst cyano, C 1 -C 4 -alkoxy, C 1 -C 4 -alkylthio, di(C 1 -C 4 -alkyl)amino, C 1 -C 4 -alkylcarbonyl, C 1 -C 4 -alkoxycarbonyl, C 1 -C 4 -alkoxy-C 1 -C 4 -alkoxycarbonyl, C 1 -C 4 -alkylaminocarbonyl, N,N-di
- p is 2, 3 or 4;
- q is 1, 2, 3, 4 or 5;
- the invention furthermore relates to processes for the preparation of compounds of the formula I, to compositions comprising them, and to the use of these derivatives or compositions comprising them for controlling harmful plants.
- the compounds of the formula I may contain one or more chiral centers, in which case they are present as enantiomer or diastereomer mixtures.
- the invention relates both to the pure enantiomers or diastereomers and to their mixtures.
- the compounds of the formula I can also be present in the form of their agriculturally useful salts, the type of the salt generally being of no importance. Suitable are in general the salts of those cations, or the acid addition salts of those acids, whose cations, or anions, respectively, do not adversely affect the herbicidal action of the compounds I.
- Suitable cations are, in particular, ions of the alkali metals, preferably lithium, sodium and potassium, of the alkaline earth metals, preferably calcium and magnesium, and of the transition metals, preferably manganese, copper, zinc and iron, and also ammonium, it being possible here, if desired, for one to four hydrogen atoms to be replaced by C 1 -C 4 -alkyl or hydroxy-C 1 -C 4 -alkyl and/or a phenyl or benzyl, preferably ammonium, diisopropylammonium, tetramethylammonium, tetrabutylammonium, trimethylbenzylammonium, and furthermore phosphonium ions, sulfonium ions, preferably tri(C 1 -C 4 -alkyl)sulfonium and sulfoxonium ions, preferably tri (C 1 -C 4 -alkyl)sulfoxonium.
- Anions of useful acid addition salts are mainly chloride, bromide, fluoride, hydrogensulfate, sulfate, dihydrogenphosphate, hydrogenphosphate, nitrate, hydrogencarbonate, carbonate, hexafluorosilicate, hexafluorophosphate, benzoate, and the anions of C 1 -C 4 -alkanoic acids, preferably formate, acetate, propionate and butyrate.
- C 1 -C 20 -alkyl as alkyl moiety of C 1 -C 20 -alkylcarbonyl: C 1 -C 6 -alkyl as mentioned above and heptyl, octyl, pentadecyl or heptadecyl;
- C 1 -C 4 -haloalkyl and the haloalkyl moieties of C 1 -C 4 -haloalkylcarbonyl a C 1 -C 4 -alkyl radical as mentioned above which is partially or fully substituted by fluorine, chlorine, bromine and/or iodine, i.e. e.g.
- C 1 -C 6 -haloalkyl C 1 -C 4 -haloalkyl as mentioned above and, for example, 5-fluoropentyl, 5-chloropentyl, 5-bromopentyl, 5-iodopentyl, undecafluoropentyl, 6-fluorohexyl, 6-chlorohexyl, 6-bromohexyl, 6-iodohexyl and dodecafluorohexyl;
- C 1 -C 4 -cyanoalkyl for example cyanomethyl, 1-cyanoeth-1-yl, 2-cyanoeth-1-yl, 1-cyanoprop-1-yl, 2-cyanoprop-1-yl, 3-cyanoprop-1-yl, 1-cyanoprop-2-yl, 2-cyanoprop-2-yl, 1-cyanobut-1-yl, 2-cyanobut-1-yl, 3-cyanobut-1-yl, 4-cyanobut-1-yl, 1-cyanobut-2-yl, 2-cyanobut-2-yl, 1-cyanobut-3-yl, 2-cyanobut-3-yl, 1-cyano-2-methylprop-3-yl, 2-cyano-2-methylprop-3-yl, 3-cyano-2-methylprop-3-yl and 2-cyanomethylprop-2-yl;
- C 2 -C 6 -alkenyl as alkenyl moieties of C 2 -C 6 -alkenylcarbonyl: C 3 -C 6 -alkenyl as mentioned above, and also ethenyl;
- C 2 -C 20 -alkenyl as alkenyl moieties of C 2 -C 20 -alkenylcarbonyl: C 2 -C 6 -alkenyl as mentioned above, and also 8-pentadecen-1-yl, 8-heptadecen-1-yl and 8,11-heptadecadien-1-yl;
- C 3 -C 6 -haloalkenyl a C 3 -C 6 -alkenyl radical as mentioned above which is partially or fully substituted by fluorine, chlorine, bromine and/or iodine, i.e. for example 2-chloroallyl, 3-chloroallyl, 2,3-dichloroallyl, 3,3-dichloroallyl, 2,3,3-trichloroallyl, 2,3-dichlorobut-2-enyl, 2-bromoallyl, 3-bromoallyl, 2,3-dibromoallyl, 3,3-dibromoallyl, 2,3,3-tribromoallyl or 2,3-dibromobut-2-enyl;
- C 1 -C 4 -alkoxy and the alkoxy moieties of di(C 1 -C 4 -alkoxy)methyl and di(C 1 -C 4 -alkoxy)-C 1 -C 4 -alkyl for example methoxy, ethoxy, propoxy, 1-methylethoxy, butoxy, 1-methylpropoxy, 2-methylpropoxy and 1,1-dimethylethoxy;
- C 1 -C 4 -haloalkoxy a C 1 -C 4 -alkoxy radical as mentioned above which is partially or fully substituted by fluorine, chlorine, bromine and/or iodine, i.e.
- C 1 -C 6 -haloalkoxy C 1 -C 4 -haloalkoxy as mentioned above, and also for example 5-fluoropentoxy, 5-chloropentoxy, 5-bromopentoxy, 5-iodopentoxy, undecafluoropentoxy, 6-fluorohexoxy, 6-chlorohexoxy, 6-bromohexoxy, 6-iodohexoxy and dodecafluorohexoxy;
- C 1 -C 4 -alkylthio for example methylthio, ethylthio, propylthio, 1-methylethylthio, butylthio, 1-methylpropylthio, 2-methylpropylthio and 1,1-dimethylethylthio;
- C 1 -C 4 -haloalkylthio a C 1 -C 4 -alkylthio radical as mentioned above which is partially or fully substituted by fluorine, chlorine, bromine and/or iodine, i.e.
- C 1 -C 6 -haloalkylthio C 1 -C 4 -haloalkylthio as mentioned above, and also for example 5-fluoropentylthio, 5-chloropentylthio, 5-bromopentylthio, 5-iodopentylthio, undecafluoropentylthio, 6-fluorohexylthio, 6-chlorohexylthio, 6-bromohexylthio, 6-iodohexylthio and dodecafluorohexylthio;
- C 1 -C 6 -alkylsulfinyl (C 1 -C 6 -alkyl-S( ⁇ O)—): for example methylsulfinyl, ethylsulfinyl, propylsulfinyl, 1-methylethylsulfinyl, butylsulfinyl, 1-methylpropylsulfinyl, 2-methylpropylsulfinyl, 1,1-dimethylethylsulfinyl, pentylsulfinyl, 1-methylbutylsulfinyl, 2-methylbutylsulfinyl, 3-methylbutylsulfinyl, 2,2-dimethylpropylsulfinyl, 1-ethylpropylsulfinyl, 1,1-dimethylpropylsulfinyl, 1,2-dimethylpropylsulfinyl, hexylsulf
- C 1 -C 6 -haloalkylsulfinyl C 1 -C 6 -alkylsulfinyl radical as mentioned above which is partially or fully substituted by fluorine, chlorine, bromine and/or iodine, i.e.
- fluoromethylsulfinyl for example fluoromethylsulfinyl, difluoromethylsulfinyl, trifluoromethylsulfinyl, chlorodifluoromethylsulfinyl, bromodifluoromethylsulfinyl, 2-fluoroethylsulfinyl, 2-chloroethylsulfinyl, 2-bromoethylsulfinyl, 2-iodoethylsulfinyl, 2,2-difluoroethylsulfinyl, 2,2,2-trifluoroethylsulfinyl, 2,2,2-trichloroethylsulfinyl, 2-chloro-2-fluoroethylsulfinyl, 2-chloro-2,2-difluoroethylsulfinyl, 2,2-dichloro-2-fluoroethylsulfiny
- C 1 -C 4 -alkylsulfonyl (C 1 -C 6 -alkyl-S( ⁇ O) 2 —) : for example methylsulfonyl, ethylsulfonyl, propylsulfonyl, 1-methylethylsulfonyl, butylsulfonyl, 1-methylpropylsulfonyl, 2-methylpropylsulfonyl and 1,1-dimethylethylsulfonyl;
- C 1 -C 6 -alkylsulfonyl C 1 -C 4 -alkylsulfonyl as mentioned above, and also for example pentylsulfonyl, 1-methylbutylsulfonyl, 2-methylbutylsulfonyl, 3-methylbutylsulfonyl, 1,1-dimethylpropylsulfonyl, 1,2-dimethylpropylsulfonyl, 2,2-dimethylpropylsulfonyl, 1-ethylpropylsulfonyl, hexylsulfonyl, 1-methylpentylsulfonyl, 2-methylpentylsulfonyl, 3-methylpentylsulfonyl, 4-methylpentylsulfonyl, 1,1-dimethylbutylsulfonyl, 1,2-dimethylbutylsulfonyl, 1,3-di
- C 1 -C 4 -haloalkylsulfonyl a C 1 -C 6 -alkylsulfonyl radical as mentioned above which is partially or fully substituted by fluorine, chlorine, bromine and/or iodine, i.e.
- fluoromethylsulfonyl for example fluoromethylsulfonyl, difluoromethylsulfonyl, trifluoromethylsulfonyl, chlorodifluoromethylsulfonyl, bromodifluoromethylsulfonyl, 2-fluoroethylsulfonyl, 2-chloroethylsulfonyl, 2-bromoethylsulfonyl, 2-iodoethylsulfonyl, 2,2-difluoroethylsulfonyl, 2,2,2-trifluoroethylsulfonyl, 2-chloro-2-fluoroethylsulfonyl, 2-chloro-2,2-difluoroethylsulfonyl, 2,2-dichloro-2-fluoroethylsulfonyl, 2,2,2-trichloroethylsulfony
- C 1 -C 6 -haloalkylsulfonyl a C 1 -C 4 -haloalkylsulfonyl radical as mentioned above, and also 5-fluoropentylsulfonyl, 5-chloropentylsulfonyl, 5-bromopentylsulfonyl, 5-iodopentylsulfonyl, 6-fluorohexylsulfonyl, 6-bromohexylsulfonyl, 6-iodohexylsulfonyl and dodecafluorohexylsulfonyl;
- C 1 -C 4 -alkoxycarbonyl for example methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, 1-methylethoxycarbonyl, butoxycarbonyl, 1-methylpropoxycarbonyl, 2-methylpropoxycarbonyl and 1,1-dimethoxycarbonyl;
- C 1 -C 6 -alkoxycarbonyl a C 1 -C 4 -alkoxycarbonyl radical as mentioned above, and also for example: pentoxycarbonyl, 1-methylbutoxycarbonyl, 2-methylbutoxycarbonyl, 3-methylbutoxycarbonyl, 1,1-dimethylpropoxycarbonyl, 1,2-dimethylpropoxycarbonyl, 2,2-dimethylpropoxycarbonyl, 1-ethylpropoxycarbonyl, hexoxycarbonyl, 1-methylpentoxycarbonyl, 2-methylpentoxycarbonyl, 3-methylpentoxycarbonyl, 4-methylpentoxycarbonyl, 1,1-dimethylbutoxycarbonyl, 1,2-dimethylbutoxycarbonyl, 1,3-dimethylbutoxycarbonyl, 2,2-dimethylbutoxycarbonyl, 2,3-dimethylbutoxycarbonyl, 3,3-dimethylbutoxycarbonyl, 1-ethylbutoxycarbonyl, 2-ethylbutoxycarbonyl, 2-e
- C 1 -C 4 -haloalkoxycarbonyl a C 1 -C 4 -alkoxycarbonyl radical as mentioned above which is partially or fully substituted by fluorine, chlorine, bromine and/or iodine, i.e.
- fluoromethoxycarbonyl for example fluoromethoxycarbonyl, difluoromethoxycarbonyl, trifluoromethoxycarbonyl, chlorodifluoromethoxycarbonyl, bromodifluoromethoxycarbonyl, 2-fluoroethoxycarbonyl, 2-chloroethoxycarbonyl, 2-bromoethoxycarbonyl, 2-iodoethoxycarbonyl, 2,2-difluoroethoxycarbonyl, 2,2,2-trifluoroethoxycarbonyl, 2-chloro-2-fluoroethoxycarbonyl, 2-chloro-2,2-difluoroethoxycarbonyl, 2,2-dichloro-2-fluoroethoxycarbonyl, 2,2,2-trichloroethoxycarbonyl, pentafluoroethoxycarbonyl, 2-fluoropropoxycarbonyl, 3-fluoropropoxycarbonyl, 2-chloropropoxycarbonyl, 3-chloropropoxycarbon
- C 1 -C 6 -haloalkoxycarbonyl a C 1 -C 4 -haloalkoxycarbonyl radical as mentioned above, and also 5-fluoropentoxycarbonyl, 5-chloropentoxycarbonyl, 5-bromopentoxycarbonyl, 5-iodopentoxycarbonyl, 6-fluorohexoxycarbonyl, 6-bromohexoxycarbonyl, 6-iodohexoxycarbonyl and dodecafluorohexoxycarbonyl;
- C 3 -C 6 -alkenyloxy and the C 3 -C 6 -alkenyloxy moieties of C 3 -C 6 -Alkenyloxycarbonyl for example prop-1-en-1-yloxy, prop-2-en-1-yloxy, 1-methylethenyloxy, buten-1-yloxy, buten-2-yloxy, buten-3-yloxy, 1-methylprop-1-en-1-yloxy, 2-methylprop-1-en-1-yloxy, 1-methylprop-2-en-1-yloxy, 2-methylprop-2-en-1-yloxy, penten-1-yloxy, penten-2-yloxy, penten-3-yloxy, penten-4-yloxy, 1-methylbut-1-en-1-yloxy, 2-methylbut-1-en-1-yloxy, 3-methylbut-1-en-1-yloxy, 1-methylbut-2-en-1-yloxy, 2-methylbut-2-en-1-yloxy, 3-methylbut-1-en-1-yl
- C 3 -C 6 -alkynyloxy and the alkynyloxy moieties of C 3 -C 6 -alkynyloxycarbonyl for example prop-1-yn-1-yloxy, prop-2-yn-1-yloxy, but-1-yn-1-yloxy, but-1-yn-3-yloxy, but-1-yn-4-yloxy, but-2-yn-1-yloxy, pent-1-yn-1-yloxy, pent-1-yn-3-yloxy, pent-1-yn-4-yloxy, pent-1-yn-5-yloxy, pent-2-yn-1-yloxy, pent-2-yn-4-yloxy, pent-2-yn-5-yloxy, 3-methylbut-1-yn-3-yloxy, 3-methylbut-1-yn-4-yloxy, hex-1-yn-1-yloxy, hex-1-yn-3-yloxy, hex
- C 1 -C 6 -alkylamino and the alkylamino moieties of C 1 -C 6 -alkylaminocarbonyl for example methylamino, ethylamino, propylamino, 1-methylethylamino, butylamino, 1-methylpropylamino, 2-methylpropylamino, 1,1-dimethylethylamino, pentylamino, 1-methylbutylamino, 2-methylbutylamino, 3-methylbutylamino, 2,2-dimethylpropylamino, 1-ethylpropylamino, hexylamino, 1,1-dimethylpropylamino, 1,2-dimethylpropylamino, 1-methylpentylamino, 2-methylpentylamino, 3-methylpentylamino, 4-methylpentylamino, 1,1-dimethylbutylamino, 1,2-dimethylbutylamino, 1,2-dimethyl
- di(C 1 -C 4 -alkyl)amino-C 1 -C 4 -alkyl C 1 -C 4 -alkyl substituted by di(C 1 -C 4 -alkyl)amino as mentioned above, i.e., for example, N,N-dimethylaminomethyl, N,N-diethylaminomethyl, N,N-dipropylaminomethyl, N,N-di(1-methylethyl)aminomethyl, N,N-dibutylaminomethyl, N,N-di(1-methylpropyl)aminomethyl, N,N-di(2-methylpropyl)aminomethyl, N,N-di(1,1-dimethylethyl)aminomethyl, N-ethyl-N-methylaminomethyl, N-methyl-N-propylaminomethyl, N-methyl-N-(1-methylethyl)aminomethyl, N-methyl
- C 1 -C 4 -alkoxy-C 1 -C 4 -alkyl C 1 -C 4 -alkyl substituted by C 1 -C 4 -alkoxy as mentioned above, i.e., for example, methoxymethyl, ethoxymethyl, propoxymethyl, (1-methylethoxy)methyl, butoxymethyl, (1-methylpropoxy)methyl, (2-methylpropoxy)methyl, (1,1-dimethylethoxy)methyl, 2-(methoxy)ethyl, 2-(ethoxy)ethyl, 2-(Propoxy)ethyl, 2-(1-methylethoxy)ethyl, 2-(butoxy) ethyl, 2-(1-methylpropoxy) ethyl, 2-(2-methylpropoxy)ethyl, 2-(1,1-dimethylethoxy)ethyl, 2-(methoxy)propyl, 2-(ethoxy)propyl, 2-(propoxy)propyl, 2-(propoxy)prop
- C 1 -C 4 -alkylthio-C 1 -C 4 -alkyl C 1 -C 4 -alkyl substituted by C 1 -C 4 -alkylthio as mentioned above, i.e., for example, methylthiomethyl, ethylthiomethyl, propylthiomethyl, (1-methylethylthio)methyl, butylthiomethyl, (1-methylpropylthio)methyl, (2-methylpropylthio)methyl, (1,1-dimethylethylthio)methyl, 2-methylthioethyl, 2-ethylthioethyl, 2-(propylthio)ethyl, 2-(1-methylethylthio)ethyl, 2-(butylthio)ethyl, 2-(1-methylpropylthio) ethyl, 2-(2-methylpropylthio)ethyl, 2-(1,1-dimethyleth
- C 1 -C 4 -alkoxycarbonyl-C 1 -C 4 -alkyl C 1 -C 4 -alkyl substituted by C 1 -C 4 -alkoxycarbonyl, i.e., for example, methoxycarbonylmethyl, ethoxycarbonylmethyl, propoxycarbonylmethyl, (1-methylethoxycarbonyl)methyl, butoxycarbonylmethyl, (1-methylpropoxycarbonyl)methyl, (2-methylpropoxycarbonyl)methyl, (1,1-dimethylethoxycarbonyl)methyl, 2-(methoxycarbonyl)ethyl, 2-(ethoxycarbonyl)ethyl, 2-(propoxycarbonyl)ethyl, 2-(1-methylethoxycarbonyl)ethyl, 2-(butoxycarbonyl)ethyl, 2-(1-methylpropoxycarbonyl)ethyl, 2-(2-methylpropoxycarbonyl)ethyl, 2-(1,
- C 1 -C 4 -alkoxy-C 2 -C 4 -alkoxy C 2 -C 4 -alkoxy substituted by C 1 -C 4 -alkoxy as mentioned above, i.e., for example, 2-(methoxy)ethoxy, 2-(ethoxy)ethoxy, 2-(propoxy)ethoxy, 2-(1-methylethoxy)ethoxy, 2-(butoxy)ethoxy, 2-(1-methylpropoxy)ethoxy, 2-(2-methylpropoxy)ethoxy, 2-(1,1-dimethylethoxy)ethoxy, 2-(methoxy)propoxy, 2-(ethoxy)propoxy, 2-(propoxy)propoxy, 2-(1-methylethoxy)propoxy, 2-(butoxy)propoxy, 2-(1-methylpropoxy)propoxy, 2-(2-methylpropoxy)propoxy, 2-(1,1-dimethylethoxy)propoxy, 3-(methoxy)propoxy, 3-(ethoxy)propoxy, 3-(e
- C 2 -C 5 -alkanediyl for example ethane-1,2-diyl, propane-1,3-diyl, butane-1,4-diyl and pentane-1,5-diyl;
- C 1 -C 5 -alkanediyl C 2 -C 5 -alkanediyl as mentioned above, and also methanediyl;
- C 2 -C 6 -alkanediyl C 2 -C 5 -alkanediyl as mentioned above, and also hexane-1,6-diyl;
- C 3 -C 6 -cycloalkyl for example cyclopropyl, cyclobutyl, cyclopentyl and cyclohexyl;
- C 3 -C 8 -cycloalkyl C 3 -C 6 -cycloalkyl as mentioned above, and also cycloheptyl and cyclooctyl;
- 6-membered saturated rings such as:
- 6-membered partially saturated rings such as:
- 6-membered unsaturated rings such as:
- a bicyclic ring system to be formed with a fused phenyl ring or with a C 3 -C 6 -carbocycle or with a further 5- to 6-membered heterocycle.
- 6-membered unsaturated rings as mentioned above, in particular pyridin-2-yl, pyridin-3-yl, pyridin-4-yl, pyrimidin-2-yl, pyrimidin-4-yl, pyrimidin-5-yl, pyrazin-2-yl or 1,3,5-triazin-2-yl;
- all phenyl or heterocyclyl rings are preferably unsubstituted or have attached to them one to three halogen atoms and/or one nitro group, one cyano radical and/or one or two methyl, trifluoromethyl, methoxy or trifluoromethoxy substituents.
- the variables preferably have the following meanings, in each case alone or in combination:
- R 1 , R 2 are nitro, halogen, cyano, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 1 -C 6 -alkoxy, C 1 -C 6 -haloalkoxy, C 1 -C 6 -alkylthio, C 1 -C 6 -haloalkylthio, C 1 -C 6 -alkylsulfinyl, C 1 -C 6 -haloalkylsulfinyl, C 1 -C 6 -alkylsulfonyl or C 1 -C 6 -haloalkylsulfonyl;
- nitro, halogen such as, for example, chlorine and bromine
- C 1 -C 6 -alkyl such as, for example, methyl and ethyl
- C 1 -C 6 -alkoxy such as, for example, methoxy and ethoxy
- C 1 -C 6 -haloalkyl such as, for example, difluoromethyl and trifluoromethyl
- C 1 -C 6 -alkylthio such as, for example, methylthio and ethylthio
- C 1 -C 6 -alkylsulfinyl such as, for example, methylsulfinyl and ethylsulfinyl
- C 1 -C 6 -alkylsulfonyl such as, for example, methylsulfonyl, ethylsulfonyl and propylsulfonyl or C 1 -C 6 -haloalkylsulfony
- R 3 is hydrogen
- R 4 is hydrogen
- R 5 , R 6 are hydrogen, halogen, cyano, nitro, C 1 -C 4 -alkyl, C 1 -C 4 -alkoxy-C 1 -C 4 -alkyl, C 1 -C 4 -alkoxycarbonyl-C 1 -C 4 -alkyl, C 1 -C 4 -alkylthio-C 1 -C 4 -alkyl, C 1 -C 4 -haloalkyl, C 1 -C 4 -cyanoalkyl, C 3 -C 8 -cycloalkyl, C 1 -C 4 -alkoxy, C 1 -C 4 -alkoxy-C 2 -C 4 -alkoxy, C 1 -C 4 -haloalkoxy, C 1 -C 4 -alkylthio, C 1 -C 4 -haloalkylthio, di(C 1 -C 4 -alkyl)amino, COR
- R 5 and R 6 together form a C 2 -C 6 -alkanediyl chain which can be mono- to tetrasubstituted by C 1 -C 4 -alkyl and/or can be interrupted by oxygen or an unsubstituted or C 1 -C 4 -alkyl-substituted nitrogen;
- R 5 is especially preferably hydrogen, halogen, cyano, nitro, C 1 -C 4 -alkyl, C 1 -C 4 -alkoxy-C 1 -C 4 -alkyl, C 1 -C 4 -alkoxycarbonyl-C 1 -C 4 -alkyl, C 1 -C 4 -alkylthio-C 1 -C 4 -alkyl, C 1 -C 4 -haloalkyl, C 1 -C 4 -cyanoalkyl, C 3 -C 8 -cycloalkyl, C 1 -C 4 -alkoxy, C 1 -C 4 -alkoxy-C 2 -C 4 -alkoxy, C 1 -C 4 -haloalkoxy, C 1 -C 4 -alkylthio, C 1 -C 4 -haloalkylthio, di(C 1 -C 4 -alkyl)amino, COR 8
- R 6 is especially preferably hydrogen or C 1 -C 4 -alkyl; particularly preferably R 5 is hydrogen, C 1 -C 4 -alkyl, C 1 -C 4 -haloalkyl, C 1 -C 4 -alkoxycarbonyl or CONR 9 R 10 ;
- R 6 is hydrogen or C 1 -C 4 -alkyl; very especially preferably R 5 is hydrogen or C 1 -C 4 -alkyl, particularly hydrogen;
- R 6 is hydrogen
- R 7 is halogen, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 1 -C 6 -alkoxy, C 1 -C 6 -alkylthio, C 1 -C 6 -alkylsulfinyl, C 1 -C 6 -alkylsulfonyl, amino, C 1 -C 6 -alkylamino, di(C 1 -C 6 -alkyl)amino, di(C 1 -C 4 -alkoxy)methyl or COR 8 ;
- C 1 -C 4 -alkyl such as, for example, methyl, ethyl, 1-methylethyl or 1,1-dimethylethyl
- C 1 -C 4 -alkylcarbonyl such as, for example, methylcarbonyl or ethylcarbonyl, hydroxycarbonyl or C 1 -C 4 -alkoxycarbonyl such as, for example, methoxycarbonyl or ethoxycarbonyl
- C 1 -C 4 -alkyl such as, for example, methyl, ethyl, 1-methylethyl or 1,1-dimethylethyl
- C 1 -C 4 -alkylcarbonyl such as, for example, methylcarbonyl or ethylcarbonyl, hydroxycarbonyl or C 1 -C 4 -alkoxycarbonyl such as, for example, methoxycarbonyl or ethoxycarbonyl
- C 1 -C 4 -alkyl such as, for example, methyl, ethyl, 1-methylethyl or 1,1-dimethylethyl, hydroxycarbonyl or C 1 -C 4 -alkoxycarbonyl;
- C 1 -C 4 -alkyl such as, for example, methyl, ethyl, 1-methylethyl or 1,1-dimethylethyl;
- R 8 is C 1 -C 4 -alkyl, hydroxyl, C 1 -C 4 -alkoxy or NR 9 R 10 ;
- R 9 is hydrogen or C 1 -C 4 -alkyl
- R 10 is C 1 -C 4 -alkyl
- R 12 is hydroxyl, OR 19 , SR 19 , SOR 20 or SO 2 R 20 ;
- R 13 , R 17 are hydrogen, C 1 -C 4 -alkyl or C 1 -C 4 -alkylthio;
- R 14 , R 16 , R 18 are hydrogen or methyl
- R 15 is hydrogen, hydroxyl, C 1 -C 6 -alkyl or di(C 1 -C 6 -alkoxy)methyl;
- R 13 and R 14 or R 14 and R 15 or R 15 and R 18 or R 14 and R 18 or R 17 and R 18 together are C 1 -C 5 -alkanediyl which can have attached to it one, two or three substituents selected from among halogen, cyano, C 1 -C 4 -alkyl, C 1 -C 4 -haloalkyl or C 1 -C 4 -alkoxycarbonyl;
- R 15 and R 16 together are an oxygen atom
- R 19 is C 1 -C 6 -alkyl, C 1 -C 20 -alkylcarbonyl, preferably C 1 -C 6 -alkylcarbonyl, C 1 -C 6 -alkoxycarbonyl, C 1 -C 6 -alkylthiocarbonyl, it being possible for the abovementioned alkyl and alkoxy radicals to be partially or fully halogenated and/or to have attached to them one, two or three substituents selected from among cyano, C 1 -C 4 -alkoxy, C 1 -C 4 -alkylthio, C 1 -C 4 -alkylcarbonyl, C 1 -C 4 -alkoxycarbonyl or C 3 -C 6 -cycloalkyl;
- R 20 is C 1 -C 6 -alkyl which can be partially or fully halogenated and/or can have attached to it one, two or three substituents selected from among cyano, C 1 -C 4 -alkoxy, C 1 -C 4 -alkylthio, C 1 -C 4 -alkylcarbonyl, C 1 -C 4 -alkoxycarbonyl or C 3 -C 6 -cycloalkyl; phenyl, phenyl-C 1 -C 4 -alkyl, phenylcarbonyl-C 1 -C 4 -alkyl, heterocyclyl, heterocyclyl-C 1 -C 4 -alkyl or heterocyclylcarbonyl-C 1 -C 4 -alkyl, it being possible for the phenyl or heterocyclyl radical of the abovementioned radicals to be partially or fully halogenated and/or to have attached to it one, two or three substituents selected from among
- R 1 is nitro, halogen, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 1 -C 6 -alkoxy or C 1 -C 6 -haloalkoxy;
- nitro, halogen such as chlorine or bromine
- C 1 -C 4 -alkyl such as methyl or ethyl
- C 1 -C 4 -haloalkyl such as difluoromethyl or trifluoromethyl
- C 1 -C 4 -alkoxy such as methoxy or ethoxy
- C 1 -C 4 -haloalkoxy such as difluoromethoxy or trifluoromethoxy
- halogen such as chlorine or bromine, C 1 -C 4 -alkyl such as methyl or ethyl or C 1 -C 4 -alkoxy such as methoxy or ethoxy;
- halogen such as chlorine or bromine or C 1 -C 4 -alkyl such as methyl or ethyl;
- R 2 is halogen, C 1 -C 6 -haloalkyl, C 1 -C 6 -alkylthio, C 1 -C 6 -haloalkylthio, C 1 -C 6 -alkylsulfinyl, C 1 -C 6 -haloalkylsulfinyl, C 1 -C 6 -alkylsulfonyl or C 1 -C 6 -haloalkylsulfonyl;
- halogen such as fluorine or chlorine, C 1 -C 4 -haloalkyl such as difluoromethyl or trifluoromethyl, or C 1 -C 4 -alkylsulfonyl such as methylsulfonyl or ethylsulfonyl;
- halogen such as fluorine or chlorine, or C 1 -C 4 -alkylsulfonyl such as methylsulfonyl or ethylsulfonyl;
- R 3 is hydrogen
- R 3 is halogen or C 1 -C 4 -alkyl
- R 4 is hydrogen
- R 4 is hydrogen
- R 5 is hydrogen, halogen, cyano, nitro, C 1 -C 4 -alkyl, C 1 -C 4 -alkoxy-C 1 -C 4 -alkyl, C 1 -C 4 -alkoxycarbonyl-C 1 -C 4 -alkyl, C 1 -C 4 -alkylthio-C 1 -C 4 -alkyl, C 1 -C 4 -haloalkyl, C 1 -C 4 -cyanoalkyl, C 3 -C 8 -cycloalkyl, C 1 -C 4 -alkoxy, C 1 -C 4 -alkoxy-C 2 -C 4 -alkoxy, C 1 -C 4 -haloalkoxy, C 1 -C 4 -alkylthio, C 1 -C 4 -haloalkylthio, di(C 1 -C 4 -alkyl)amino, C 1 -C 4 -al
- R 6 is hydrogen or C 1 -C 4 -alkyl such as methyl or ethyl
- R 7 is halogen, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 1 -C 6 -alkoxy, C 1 -C 6 -alkylthio, C 1 -C 6 -alkylsulfinyl, C 1 -C 6 -alkylsulfonyl, amino, C 1 -C 6 -alkylamino, di(C 1 -C 6 -alkyl)amino, di(C 1 -C 6 -alkoxy)methyl, formyl, C 1 -C 4 -alkylcarbonyl, C 1 -C 4 -haloalkylcarbonyl, hydroxycarbonyl, C 1 -C 4 -alkoxycarbonyl, C 1 -C 4 -haloalkoxycarbonyl or CONR 9 R 10 ;
- halogen such as chlorine or bromine
- C 1 -C 4 -alkyl such as methyl, ethyl, 1-methylethyl or 1,1-dimethylethyl
- C 1 -C 4 -alkoxy such as methoxy or ethoxy
- C 1 -C 4 -alkylthio such as methylthio or ethylthio
- C 1 -C 4 -alkylsulfinyl such as methylsulfinyl or ethylsulfinyl
- C 1 -C 4 -alkylsulfonyl such as methylsulfonyl or ethylsulfonyl
- amino C 1 -C 4 -alkylamino such as methylamino or ethylamino, di(C 1 -C 4 -alkyl)amino such as dimethylamino or diethylamino, di(C 1 -
- C 1 -C 4 -alkyl such as methyl, ethyl, 1-methylethyl or 1,1-dimethylethyl
- C 1 -C 4 -alkylcarbonyl such as methylcarbonyl or ethylcarbonyl, hydroxycarbonyl or C 1 -C 4 -alkoxycarbonyl such as methoxycarbonyl or ethoxycarbonyl
- C 1 -C 4 -alkyl such as methyl, ethyl, 1-methylethyl or 1,1-dimethylethyl
- C 1 -C 4 -alkylcarbonyl such as methylcarbonyl or ethylcarbonyl, hydroxycarbonyl or C 1 -C 4 -alkoxycarbonyl such as methoxycarbonyl or ethoxycarbonyl
- C 1 -C 4 -alkyl such as methyl, ethyl, 1-methylethyl or 1,1-dimethylethyl, hydroxycarbonyl or C 1 -C 4 -alkoxycarbonyl or ethoxycarbonyl;
- C 1 -C 4 -alkyl such as methyl, ethyl, 1-methylethyl or 1,1-dimethylethyl.
- R 12 is hydroxyl, OR 19 or SR 19 ;
- R 19 is C 1 -C 6 -alkyl, C 1 -C 20 -alkylcarbonyl, C 1 -C 6 -alkoxycarbonyl, C 1 -C 6 -alkylthiocarbonyl, it being possible for the alkyl and alkoxy radicals to be partially or fully halogenated and/or to have attached to them one, two or three substituents selected from among cyano, C 1 -C 4 -alkoxy, C 1 -C 4 -alkylthio, C 1 -C 4 -alkylcarbonyl, C 1 -C 4 -alkoxycarbonyl or C 3 -C 6 -cycloalkyl;
- Heterocyclyl is preferably a 5-membered unsaturated ring or a 6-membered unsaturated ring, in particular pyridin-2-yl or pyridin-3-yl.
- heterocyclyl (alone or in combination) is 5-membered unsaturated rings wth a hetero atom such as 2-furyl, 3-furyl, 2-thienyl, 3-thienyl, pyrrol-2-yl or pyrrol-3-yl;
- heterocyclyl is 2-thienyl or 3-thienyl.
- R 12 is hydroxyl
- R 13 and R 17 are hydrogen, C 1 -C 4 -alkyl or C 1 -C 4 -alkylthio;
- R 14 , R 16 , R 18 are hydrogen or methyl
- R 15 is hydrogen, hydroxyl, C 1 -C 6 -alkyl or di(C 1 -C 6 -alkoxy)methyl;
- R 13 and R 14 or R 14 and R 15 or R 15 and R 16 or R 14 and R 18 or R 17 and R 18 together are C 1 -C 5 -alkanediyl which can have attached to it one, two or three substituents selected from among halogen, cyano, C 1 -C 4 -alkyl, C 1 -C 4 -haloalkyl or C 1 -C 4 -alkoxycarbonyl;
- R 15 and R 16 together are an oxygen atom.
- R 13 , R 17 are hydrogen or C 1 -C 4 -alkyl
- R 14 , R 16 , R 18 are hydrogen or methyl
- R 15 is hydrogen, C 1 -C 6 -alkyl or di(C 1 -C 6 -alkoxy)methyl
- R 14 and R 18 together are C 1 -C 5 -alkanediyl which can have attached to it one, two or three substituents selected from among halogen, cyano, C 1 -C 4 -alkyl, C 1 -C 4 -haloalkyl or C 1 -C 4 -alkoxycarbonyl;
- R 15 and R 16 together are an oxygen atom.
- the compounds Ia3. especially the compounds Ia3.1-Ia3.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 15 and R 16 are methyl.
- the compounds Ia6 are especially the compounds Ia6.1-Ia6.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 14 and R 18 together are ethane-1,2-diyl.
- the compounds Ia7 are particularly preferred.
- the compounds Ia7.1-Ia7.64 which differ from the compounds Ia1.1-Ia1.64 by the fact that R 13 , R 14 , R 17 and R 18 are methyl and R 15 and R 16 are oxygen.
- the compounds Ia8. especially the compounds Ia8.1-Ia8.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 15 is hydroxyl.
- the compounds Ia9. especially the compounds Ia9.1-Ia9.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 is methyl.
- the compounds Ia10. especially the compounds Ia10.1-Ia10.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 and R 15 are methyl.
- the compounds Ia11. especially the compounds Ia11.1-Ia11.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 , R 15 and R 16 are methyl.
- the compounds Ia12. especially the compounds Ia12.1-Ia12.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 , R 13 and R 17 are methyl.
- the compounds la14 especially the compounds Ia14.1-Ia14.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 is methyl and R 14 and R 18 together are ethane-1,2-diyl.
- the compounds Ia15 are particularly preferred., especially the compounds Ia15.1-Ia15.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 , R 13 , R 14 , R 17 and R 18 are methyl and R 15 and R 16 are oxygen.
- the compounds Ia16 are particularly preferred., especially the compounds Ia16.1-Ia16.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 is methyl and R 15 is hydroxyl.
- the compounds Ia18 are especially the compounds Ia18.1-Ia18.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 is trifluoromethyl and R 15 is methyl.
- the compounds Ia19 are particularly preferred., especially the compounds Ia19.1 -Ia19.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 is trifluoromethyl and R 15 and R 16 are methyl.
- the compounds Ia20 are particularly preferred., especially the compounds Ia20.1-Ia20.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 is trifluoromethyl and R 13 and R 17 are methyl.
- the compounds Ia21 are particularly preferred., especially the compounds Ia21.1-Ia21.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 is trifluoromethyl, R 13 is methylthio and R 14 is methyl.
- the compounds Ia22. especially the compounds Ia22.1-Ia22.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 is trifluoromethyl, R 14 and R 18 together are ethane-1,2-diyl.
- the compounds Ia23 are particularly preferred, especially the compounds Ia23.1-Ia23.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 is trifluoromethyl, R 13 , R 14 , R 17 and R 18 are methyl and R 16 is oxygen.
- the compounds Ia24 are particularly preferred., especially the compounds Ia24.1-Ia24.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 is trifluoromethyl and R 15 is hydroxyl.
- the compounds Ia26 are particularly preferred., especially the compounds Ia26.1-Ia26.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 is methoxy and R 15 is methyl.
- the compounds Ia27 are particularly preferred., especially the compounds Ia27.1-Ia27.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 is methoxy and R 15 and R 16 are methyl.
- the compounds Ia28. especially the compounds Ia28.1-Ia28.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 is methoxy and R 13 and R 17 are methyl.
- the compounds Ia29. especially the compounds Ia29.1-Ia29.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 is methoxy, R 13 is methylthio and R 14 is methyl.
- the compounds Ia30. especially the compounds Ia30.1-Ia30.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 is methoxy, R 14 and R 18 together are ethane-1,2-diyl.
- the compounds Ia31 are particularly preferred., especially the compounds Ia31.1-Ia31.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 is methoxy: R 13 , R 14 , R 17 and R 18 are methyl and R 15 and R 16 together are oxygen.
- the compounds Ia32. especially the compounds Ia32.1-Ia32.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 is methoxy and R 15 is hydroxyl.
- the compounds Ia33 are particularly preferred., especially the compounds Ia33.1-Ia33.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 2 is ethylsulfonyl.
- the compounds Ia34 are particularly preferred., especially the compounds Ia34.1-Ia34.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 2 is ethylsulfonyl and R 15 is methyl.
- the compounds Ia35 are particularly preferred., especially the compounds Ia35.1-Ia35.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 2 is ethylsulfonyl and R 15 and R 16 are methyl.
- the compounds Ia36 are particularly preferred., especially the compounds Ia36.1-Ia36.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 2 is ethylsulfonyl and R 13 and R 17 are methyl.
- the compounds Ia37 are particularly preferred., especially the compounds Ia37.1-Ia37.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 2 is ethylsulfonyl, R 13 is methylthio and R 14 is methyl.
- the compounds Ia38 are particularly preferred., especially the compounds Ia38.1-Ia38.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 2 is ethylsulfonyl, R 14 and R 18 together are ethane-1,2-diyl.
- the compounds Ia39 are particularly preferred, especially the compounds Ia39.1-Ia39.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 2 is ethylsulfonyl, R 13 , R 14 , R 17 and R 18 are methyl and R 15 and R 16 together are oxygen.
- the compounds Ia40 are particularly preferred., especially the compounds Ia40.1-Ia40.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 2 is ethylsulfonyl and R 15 is hydroxyl.
- the compounds Ia41 are particularly preferred., especially the compounds Ia4.1-Ia41.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 is methyl and R 2 is ethylsulfonyl.
- the compounds Ia42 are particularly preferred.
- the compounds Ia42.1-Ia42.64 which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 and R 15 are methyl and R 2 is ethylsulfonyl.
- the compounds Ia43 are particularly preferred, especially the compounds Ia43.1-Ia43.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 , R 15 and R 16 are ethyl and R 2 is ethylsulfonyl.
- the compounds Ia44 are particularly preferred, especially the compounds Ia44.1-Ia44.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 , R 13 and R 17 are methyl and R 2 is ethylsulfonyl.
- the compounds Ia45 are particularly preferred, especially the compounds Ia45.1-Ia45.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 and R 14 are methyl and R 13 is methylthio.
- the compounds Ia46 are especially the compounds Ia46.1-Ia46.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 is methyl, R 2 is ethylsulfonyl and R 14 and R 18 together are ethane-1,2-diyl.
- the compounds Ia47 are particularly preferred.
- the compounds Ia47.1-Ia47.64 which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 , R 13 , R 14 , R 17 and R 18 are methyl, R 2 is ethylsulfonyl and R 15 and R 16 together are oxygen.
- the compounds Ia48 are particularly preferred., especially the compounds Ia48.1-Ia48.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 is methyl, R 2 is ethylsulfonyl and R 15 is hydroxyl.
- the compounds Ia49. especially the compounds Ia49.1-Ia49.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 is trifluoromethyl and R 2 is ethylsulfonyl.
- the compounds Ia50 are particularly preferred.
- the compounds Ia50.1-Ia50.64 which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 is trifluoromethyl, R 2 is ethylsulfonyl and R 15 is methyl.
- the compounds Ia51 are particularly preferred., especially the compounds Ia51.1-Ia51.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 is trifluoromethyl, R 2 is ethylsulfonyl and R 15 and R 16 are methyl.
- the compounds Ia52. especially the compounds Ia52.1-Ia52.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 is trifluoromethyl, R 2 is ethylsulfonyl and R 13 and R 17 are methyl.
- the compounds Ia53 are particularly preferred., especially the compounds Ia53.1-Ia53.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 is trifluoromethyl, R 2 is ethylsulfonyl, R 13 is methylthio and R 14 is methyl.
- the compounds Ia54 are particularly preferred., especially the compounds Ia54.1-Ia54.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 is trifluoromethyl, R 2 is ethylsulfonyl and R 14 and R 18 together are ethane-1,2-diyl.
- the compounds Ia55 are especially the compounds Ia55.1-Ia55.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 is trifluoromethyl, R 2 is ethylsulfonyl, R 13 , R 14 , R 17 and R 18 are methyl and R 15 and R 16 together are oxygen.
- the compounds Ia56 are particularly preferred, especially the compounds Ia56.1-Ia56.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 is trifluoromethyl, R 2 is ethylsulfonyl and R 15 is hydroxyl.
- the compounds Ia57 are especially the compounds Ia57.1-Ia57.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 is methoxy and R 2 is ethylsulfonyl.
- the compounds Ia58. especially the compounds Ia58.1-Ia58.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 is methoxy, R 2 is ethylsulfonyl and R 15 is methyl.
- the compounds Ia59 are particularly preferred, especially the compounds Ia59.1-Ia59.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 is methoxy, R 2 is ethylsulfonyl and R 15 and R 16 are methyl.
- the compounds Ia60 are particularly preferred.
- the compounds Ia60.1-Ia60.64 which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 is methoxy, R 2 is ethylsulfonyl and R 13 and R 17 are methyl.
- the compounds Ia61 are particularly preferred., especially the compounds Ia61.1-Ia61.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 is methoxy, R 2 is ethylsulfonyl, R 13 is methylthio and R 14 is methyl.
- the compounds Ia62. especially the compounds Ia62.1-Ia62.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 is methoxy, R 2 is ethylsulfonyl and R 14 and R 18 together are ethane-1,2-diyl.
- the compounds Ia63 are particularly preferred, especially the compounds Ia63.1-Ia63.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 is methoxy, R 2 is ethylsulfonyl, R 13 , R 14 , R 17 and R 18 are methyl and R 15 and R 16 together are oxygen.
- the compounds Ia64 are particularly preferred., especially the compounds Ia64.1-Ia64.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that RI is methoxy, R 2 is ethylsulfonyl and R 15 is hydroxyl.
- the compounds Ia68. especially the compounds Ia68.1-Ia68.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 2 is chlorine and R 13 and R 17 are methyl.
- the compounds Ia69. especially the compounds Ia69.1-Ia69.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 2 is chlorine, R 13 is methylthio and R 14 is methyl.
- the compounds Ia70 are particularly preferred., especially the compounds Ia70.1-Ia70.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 2 is chlorine and R 14 and R 18 together are ethane-1,2-diyl.
- the compounds Ia71 are particularly preferred.
- the compounds Ia71.1-Ia71.64 which differ from the compounds Ia1.1-Ia1.64 by the fact that R 2 is chlorine, R 13 , R 14 , R 17 and R 18 are methyl and R 15 and R 16 together are oxygen.
- the compounds Ia72. especially the compounds Ia72.1-Ia72.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 2 is chlorine and R 15 is hydroxyl.
- the compounds Ia75 are particularly preferred, especially the compounds Ia75.1-Ia75.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 , R 15 and R 18 are methyl and R 2 is chlorine.
- the compounds Ia77 are particularly preferred, especially the compounds Ia77.1-Ia77.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 and R 14 are methyl, R 2 is chlorine and R 13 is methylthio.
- the compounds Ia78. especially the compounds Ia78.1-Ia78.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 is methyl, R 2 is chlorine and R 14 and R 18 together are ethane-1,2-diyl.
- the compounds Ia79. especially the compounds Ia79.1-Ia79.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 , R 13 , R 14 , R 17 and R 18 are methyl, R 2 is chlorine and R 15 and R 16 together are oxygen.
- the compounds Ia80 are particularly preferred., especially the compounds Ia80.1-Ia80.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 is methyl, R 2 is chlorine and R 15 is hydroxyl.
- the compounds Ia81. especially the compounds Ia81.1-Ia81.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 is trifluoromethyl and R 2 is chlorine.
- the compounds Ia82. especially the compounds Ia82.1-Ia82.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 is trifluoromethyl, R 2 is chlorine and R 15 is methyl.
- the compounds Ia83 are particularly preferred., especially the compounds Ia83.1-Ia83.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 is trifluoromethyl, R 2 is chlorine and R 15 and R 16 are methyl.
- the compounds Ia84 are especially the compounds Ia84.1-Ia84.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 is trifluoromethyl, R 2 is chlorine and R 13 and R 17 are methyl.
- the compounds Ia86 are especially the compounds Ia86.1-Ia86.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 is trifluoromethyl, R 2 is chlorine and R 14 and R 18 together are ethane-1,2-diyl.
- the compounds Ia87. especially the compounds Ia87.1-Ia87.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 is trifluoromethyl, R 2 is chlorine, R 13 , R 14 , R 17 and R 18 are methyl and R 15 and R 16 together are oxygen.
- the compounds Ia88. especially the compounds Ia88.1-Ia88.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 is trifluoromethyl, R 2 is chlorine and R 15 is hydroxyl.
- the compounds Ia89. especially the compounds Ia89.1-Ia89.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 is methoxy and R 2 is chlorine.
- the compounds Ia90. especially the compounds Ia90.1-Ia90.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 is methoxy, R 2 is chlorine and R 15 is methyl.
- the compounds Ia91 are particularly preferred, especially the compounds Ia91.1-Ia91.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 is methoxy, R 2 is chlorine and R 15 and R 16 are methyl.
- the compounds Ia92. especially the compounds Ia92.1-Ia92.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that RI is methoxy, R 2 is chlorine and R 13 and R 17 are methyl.
- the compounds Ia93. especially the compounds Ia93.1-Ia93.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 is methoxy, R 2 is chlorine, R 13 is methylthio and R 14 is methyl.
- the compounds Ia94 are particularly preferred., especially the compounds Ia94.1-Ia94.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 is methoxy, R 2 is chlorine and R 14 and R 18 together are ethane-1,2-diyl.
- the compounds Ia95 are particularly preferred, especially the compounds Ia95.1-Ia95.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 is methoxy, R 2 is chlorine, R 13 , R 14 , R 12 and R 18 are methyl and R 15 and R 16 together are oxygen.
- the compounds Ia96 are particularly preferred., especially the compounds Ia96.1-Ia96.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 is methoxy, R 2 is chlorine and R 15 is hydroxyl.
- the compounds Ia97. especially the compounds Ia97.1-Ia97.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 2 is trifluoromethyl.
- the compounds Ia98. especially the compounds Ia98.1-Ia98.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 2 is trifluoromethyl and R 15 is methyl.
- the compounds Ia99. especially the compounds Ia99.1-Ia99.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 2 is trifluoromethyl and R 15 and R 16 are methyl.
- the compounds Ia100 are especially the compounds Ia100.1-Ia101.64 which differ from the compounds Ia1.1-Ia1.64 by the fact that R 2 is trifluoromethyl and R 13 and R 17 are methyl.
- the compounds Ia101 are especially the compounds Ia101.1-Ia101.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 2 is trifluoromethyl, R 13 is methylthio and R 14 is methyl.
- the compounds Ia102. especially the compounds Ia102.1-Ia102.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 2 is trifluoromethyl and R 14 and R 18 together are ethane-1,2-diyl.
- the compounds Ia103 are especially the compounds Ia103.1-Ia103.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 2 is trifluoromethyl, R 13 , R 14 , R 17 and R 18 are methyl and R 15 and R 16 together are oxygen.
- the compounds Ia104 are particularly preferred., especially the compounds Ia104.1-Ia104.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 2 is trifluoromethyl and R 15 is hydroxyl.
- the compounds Ia105 are particularly preferred., especially the compounds Ia105.1-Ia105.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 is methyl and R 2 is trifluoromethyl.
- the compounds Ia106 are particularly preferred., especially the compounds Ia106.1-Ia106.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 and R 15 are methyl and R 2 is trifluoromethyl.
- the compounds Ia107. especially the compounds Ia107.1-Ia107.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 , R 15 and R 16 are methyl and R 2 is trifluoromethyl.
- the compounds Ia108. especially the compounds Ia108.1-Ia108.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 , R 13 and R 17 are methyl and R 2 is trifluoromethyl.
- the compounds Ia109. especially the compounds Ia109.1-Ia109.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 and R 14 are methyl, R 2 is trifluoromethyl and R 13 is methylthio.
- the compounds Ia110 are especially the compounds Ia110.1-Ia110.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 is methyl, R 2 is trifluoromethyl and R 14 and R 18 together are ethane-1,2-diyl.
- the compounds Ia111 are particularly preferred.
- the compounds Ia111.1-Ia111.64 which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 , R 13 , R 14 , R 17 and R 18 are methyl, R 2 is trifluoromethyl and R 15 and R 16 together are oxygen.
- the compounds Ia112. especially the compounds Ia112.1-Ia112.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 is methyl, R 2 is trifluoromethyl and R 15 is hydroxyl.
- the compounds Ia113 are equally particularly preferred., especially the compounds Ia113.1-Ia113.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 and R 2 are trifluoromethyl.
- the compounds Ia114 are particularly preferred, especially the compounds Ia114.1-Ia114.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 and R 2 are trifluoromethyl and R 15 is methyl.
- the compounds Ia115. especially the compounds Ia115.1-Ia115.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 and R 2 are trifluoromethyl and R 15 and R 16 are methyl.
- the compounds Ia116. especially the compounds Ia116.1-Ia116.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 and R 2 are trifluoromethyl and R 13 and R 17 are methyl.
- the compounds Ia117 are especially the compounds Ia117.1-Ia117.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 and R 2 are trifluoromethyl, R1 3 is methylthio and R 14 is methyl.
- the compounds Ia118. especially the compounds Ia118.1-Ia118.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 and R 2 are trifluoromethyl and R 14 and R 18 together are ethane-1,2-diyl.
- the compounds Ia119. especially the compounds Ia119.1-Ia119.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 and R 2 are trifluoromethyl, R 13 , R 14 , R 17 and R 18 are methyl and R 15 and R 16 together are oxygen.
- the compounds Ia120. especially the compounds Ia120.l -Ia120.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 and R 2 are trifluoromethyl and R 15 is hydroxyl.
- the compounds Ia121 are equally particularly preferred., especially the compounds Ia121.1-Ia121.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 is methoxy and R 2 is trifluoromethyl.
- the compounds Ia122 are particularly preferred., especially the compounds Ia122.1-Ia122.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 is methoxy, R 2 is trifluoromethyl and R 15 is methyl.
- the compounds Ia123 are especially the compounds Ia123.1-Ia123.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 is methoxy, R 2 is trifluoromethyl and R 15 and R 16 are methyl.
- the compounds Ia124 are especially the compounds Ia124.1-Ia124.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 is methoxy, R 2 is trifluoromethyl and R 13 and R 17 are methyl.
- the compounds Ia125 are particularly preferred., especially the compounds Ia125.1-Ia125.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 is methoxy, R 2 is trifluoromethyl, R 13 is methylthio and R 14 is methyl.
- the compounds Ia126 are particularly preferred., especially the compounds Ia126.1-Ia126.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 is methoxy, R 2 is trifluoromethyl and R 14 and R 18 together are ethane-1,2-diyl.
- the compounds Ia127 are particularly preferred., especially the compounds Ia127.1-Ia127.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 is methoxy, R 2 is trifluoromethyl, R 13 , R 14 , R 17 and R 18 are methyl and R 15 and R 16 together are oxygen.
- the compounds Ia128 are especially the compounds Ia128.1-Ia128.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 is methoxy, R 2 is trifluoromethyl and R 15 is hydroxyl.
- the compounds Ia129. especially the compounds Ia129.1-Ia129.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 3 is chlorine.
- the compounds Ia131. especially the compounds Ia131.1-Ia131.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 3 is chlorine and R 15 and R 16 are methyl.
- the compounds Ia133 are particularly preferred., especially the compounds Ia133.1-Ia133.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 3 is chlorine, R 13 is methylthio and R 14 is methyl.
- the compounds Ia134 are particularly preferred., especially the compounds Ia134.1-Ia134.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 3 is chlorine and R 14 and R 18 together are ethane-1,2-diyl.
- the compounds Ia135. especially the compounds Ia135.1-Ia135.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 3 is chlorine, R 13 , R 14 , R 17 and R 18 are methyl and R 15 and R 16 together are oxygen.
- the compounds Ia136 are particularly preferred., especially the compounds Ia136.1-Ia136.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 3 is chlorine and R 15 is hydroxyl.
- the compounds Ia137 are particularly preferred., especially the compounds Ia137.1-Ia137.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 2 is ethylsulfonyl and R 3 is chlorine.
- the compounds Ia138. especially the compounds Ia138.1-Ia138.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 2 is ethylsulfonyl, R 3 is chlorine and R 15 is methyl.
- the compounds Ia139 are particularly preferred., especially the compounds Ia139.1-Ia139.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 2 is ethylsulfonyl, R 3 is chlorine and R 15 and R 16 are methyl.
- the compounds Ia140. especially the compounds Ia140.l -Ia140.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 2 is ethylsulfonyl, R 3 is chlorine and R 13 and R 17 are methyl.
- the compounds Ia141 are particularly preferred., especially the compounds Ia141.1-Ia141.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 2 is ethylsulfonyl, R 3 is chlorine, R 13 is methylthio and R 14 is methyl.
- the compounds Ia142 are particularly preferred., especially the compounds Ia142.1-Ia142.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 2 is ethylsulfonyl, R 3 is chlorine and R 14 and R 18 together are ethane-1,2-diyl.
- the compounds Ia143 are particularly preferred., especially the compounds Ia143.1-Ia143.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 2 is ethylsulfonyl, R 3 is chlorine, R 13 , R 14 , R 17 and R 18 are methyl and R 15 and R 16 together are oxygen.
- the compounds Ia144 are particularly preferred., especially the compounds Ia144.1-Ia144.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 2 is ethylsulfonyl, R 3 is chlorine and R 15 is hydroxyl.
- the compounds Ia147. especially the compounds Ia147.1-Ia147.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 , R 3 , R 15 and R 16 are methyl.
- the compounds Ia148. especially the compounds Ia148.1-Ia148.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 , R 3 , R 13 and R 17 are methyl.
- the compounds Ia149. especially the compounds Ia149.1-Ia149.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 , R 3 and R 14 are methyl and R 13 is methylthio.
- the compounds Ia150 are particularly preferred.
- the compounds Ia150.1-Ia150.64 which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 and R 3 are methyl and R 14 and R 18 together are ethane-1,2-diyl.
- the compounds Ia151 are particularly preferred., especially the compounds Ia151.1-Ia151.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 , R 3 , R 13 , R 14 , R 17 and R 18 are methyl and R 15 and R 16 together are oxygen.
- the compounds Ia152 are particularly preferred.
- the compounds Ia152.1-Ia152.64 which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 and R 3 are methyl and R 15 is hydroxyl.
- the compounds Ia153 are particularly preferred., especially the compounds Ia153.1-Ia153.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 and R 3 are methyl and R 2 is ethylsulfonyl.
- the compounds Ia154 are particularly preferred., especially the compounds Ia154.1-Ia154.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 , R 3 and R 15 are methyl and R 2 is ethylsulfonyl.
- the compounds Ia155 are particularly preferred.
- the compounds Ia155.1-Ia155.64 which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 , R 3 , R 15 and R 16 are methyl and R 2 is ethylsulfonyl.
- the compounds Ia156 are particularly preferred.
- the compounds Ia156.1-Ia156.64 which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 , R 3 , R 13 and R 17 are methyl and R 2 is ethylsulfonyl.
- the compounds Ia157. especially the compounds Ia157.1-Ia157.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 , R 3 an& R 14 are methyl, R 2 is ethylsulfonyl and R 13 is methylthio.
- the compounds Ia158 are particularly preferred.
- the compounds Ia158.1-Ia158.64 which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 and R 3 are methyl, R 2 is ethylsulfonyl and R 14 and R 18 together are ethane-1,2-diyl.
- the compounds Ia159 are particularly preferred.
- the compounds Ia159.1-Ia159.64 which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 , R 3 , R 13 , R 14 , R 17 and R 18 are methyl, R 2 is ethylsulfonyl and R 15 and R 16 together are oxygen.
- the compounds Ia160 are particularly preferred.
- the compounds Ia160.1-Ia160.64 which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 and R 3 are methyl, R 2 is ethylsulfonyl and R 15 is hydroxyl.
- the compounds Ia161. especially the compounds Ia161.1-Ia161.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 and R 3 are methyl and R 2 is chlorine.
- the compounds Ia162. especially the compounds Ia162.1-Ia162.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 , R 3 and R 15 are methyl and R 2 is chlorine.
- the compounds Ia163. especially the compounds Ia163.1-Ia163.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 , R 3 , R 15 and R 16 are methyl and R 2 is chlorine.
- the compounds Ia164 are particularly preferred., especially the compounds Ia164.1-Ia164.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 , R 3 , R 13 and R 17 are methyl and R 2 is chlorine.
- the compounds Ia165 are particularly preferred., especially the compounds Ia165.1-Ia165.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 , R 3 and R 14 are methyl, R 2 is chlorine and R 13 is methylthio.
- the compounds Ia166 are particularly preferred., especially the compounds Ia166.1-Ia166.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 and R 3 are methyl, R 2 is chlorine and R 14 and R 18 together are ethane-1,2-diyl.
- the compounds Ia167 are particularly preferred.
- the compounds Ia167.1-Ia167.64 which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 , R 3 , R 13 , R 14 , R 17 and R 18 are methyl, R 2 is chlorine and R 15 and R 16 together are oxygen.
- the compounds Ia168. especially the compounds Ia168.1-Ia168.64, which differ from the compounds Ia1.1-Ia1.64 by the fact that R 1 and R 3 are methyl and R 15 is hydroxyl.
- R 1 is halogen, C 1 -C 6 -alkyl or C 1 -C 6 -alkoxy
- halogen such as chlorine or bromine, C 1 -C 4 -alkyl such as methyl, ethyl or propyl, C 1 -C 4 -alkoxy such as methoxy or ethoxy;
- R 2 is halogen or C 1 -C 6 -alkylsulfonyl
- halogen such as chlorine or bromine or C 1 -C 4 -alkylsulfonyl such as methylsulfonyl or ethylsulfonyl;
- R 3 is hydrogen
- R hu 4 is hydrogen
- R 5 is hydrogen
- R 6 is hydrogen
- R 7 is C 1 -C 6 -alkyl, C 1 -C 4 -alkylcarbonyl or C 1 -C 4 -alkoxycarbonyl; preferably C 1 -C 6 -alkyl such as methyl, ethyl, 1-methylethyl or 1,1-dimethylethyl, methylcarbonyl or ethylcarbonyl, methoxycarbonyl or ethoxycarbonyl;
- R 12 is hydroxyl
- R 13 is hydrogen or C 1 -C 4 -alkyl
- R 14 is hydrogen or C 1 -C 4 -alkyl
- R 15 is hydrogen or C 1 -C 4 -alkyl
- R 16 is hydrogen or C 1 -C 4 -alkyl
- R 17 is hydrogen or C 1 -C 4 -alkyl
- R 18 is hydrogen or C 1 -C 4 -alkyl
- R 15 and R 16 together are an oxygen atom
- R 14 and R 18 together are C 1 -C 5 -alkanediyl, in particular 1,2-ethanediyl.
- L 1 is a nucleophilically displaceable leaving group such as halogen, e.g. bromine or chlorine, hetaryl, e.g. imidazolyl or pyridyl, carboxylate, e.g. acetate, trifluoroacetate and the like.
- halogen e.g. bromine or chlorine
- hetaryl e.g. imidazolyl or pyridyl
- carboxylate e.g. acetate, trifluoroacetate and the like.
- the activated carboxylic acid can be employed directly, such as in the case of the carbonyl halides, or generated in situ, for example with dicyclohexylcarbodiimide, triphenylphosphane/azodicarboxylic ester, 2-pyridine disulfide/triphenylphosphane, carbonyldiimidazole and the like.
- auxiliary base it may be advantageous to carry out the acylation reaction in the presence of a base.
- the reactants and the auxiliary base are expediently employed in equimolar amounts.
- An excess of the auxiliary base for example 1.2 to 2.5 mol equivalents, especially 1.2 to 1.5 mol equivalents, based on II, may be advantageous under certain circumstances.
- Auxiliary bases which are suitable are tertiary alkylamines, pyridine or alkali metal carbonates.
- Solvents which can be employed are, for example, chlorinated hydrocarbons such as methylene chloride, 1,2-dichloroethane, aromatic hydrocarbons such as toluene, xylene, chlorobenzene, ethers such as diethyl ether, methyl tert-butyl ether, tetrahydrofuran, dioxane, polar aprotic solvents such as acetonitrile, dimethylformamide, dimethyl sulfoxide, or esters such as ethyl acetate, or mixtures of these.
- Solvents which can be used are, for example, acetonitrile, methylene chloride, 1,2-dichloroethane, dioxane, ethyl acetate, toluene or mixtures of these.
- Preferred solvents are acetonitrile and dioxane.
- Suitable bases are tertiary amines such as triethylamine, pyridine or alkali metal carbonates such as sodium carbonate or potassium carbonate, which are preferably employed in equimolar amounts or up to a four-fold excess based on the ester.
- triethylamine or alkali metal carbonates are employed, preferably in twice the equimolar ratio based on the ester.
- Suitable cyano compounds are inorganic cyanides, such as sodium cyanide, potassium cyanide and organic cyano compounds such as acetone cyanohydrin or trimethylsilyl cyanide. They are employed in an amount of 1 to 50 mol percent based on the ester. Preferably, acetone cyanohydrin or trimethylsilyl cyanide are employed, for example in an amount of 5 to 25, preferably 5 to 15, in particular 10, mol percent based on the ester.
- the reaction mixture is acidified with dilute mineral acid, such as 5% strength hydrochloric acid or sulfuric acid, and extracted With an organic solvent, for example methylene chloride or ethyl acetate.
- the organic extract can be extracted with 5-10% strength alkali metal carbonate solution, for example sodium carbonate or potassium carbonate solution.
- the aqueous phase is acidified, and the precipitate which forms is filtered off with suction and/or extracted with methylene chloride or ethyl acetate, dried and concentrated.
- L 2 is a nucleophilically displaceable leaving group such as halogen, e.g. bromine or chlorine, or hetaryl, e.g. imidazolyl, pyridyl, sulfonate.
- halogen e.g. bromine or chlorine
- hetaryl e.g. imidazolyl, pyridyl, sulfonate.
- the compounds of the formula V can be employed directly, such as, for example, in the case of the sulfonyl halides or sulfonic anhydrides, or generated in situ, for example activated sulfonic acids (by means of sulfonic acid and dicyclohexylcarbonyldiimide, carbonyldiimidazole and the like).
- the starting compounds are employed in an equimolar ratio. However, it may also be advantageous to employ one or the other component in excess.
- auxiliary base it may be advantageous to carry out the reaction in the presence of a base.
- the reactants and the auxiliary base are expediently employed in equimolar amounts. Under certain circumstances, an excess of the auxiliary base, for example 1.5 to 3 mol equivalents based on II, may be advantageous.
- Suitable auxiliary bases are tertiary alkylamines such as triethylamine or pyridine, alkali metal carbonates, e.g. sodium carbonate or potassium carbonate, and alkali metal hydrides, e.g. sodium hydride. Triethylamine and pyridine are preferably used.
- suitable solvents are chlorinated hydrocarbons such as methylene chloride or 1,2-dichloroethane, aromatic hydrocarbons, e.g. toluene, xylene or chlorobenzene, ethers such as diethyl ether, methyl tert-butyl ether, tetrahydrofuran or dioxane, polar aprotic solvents such as acetonitrile, dimethylformamide or dimethyl sulfoxide, or esters such as ethyl acetate, or mixtures of these.
- chlorinated hydrocarbons such as methylene chloride or 1,2-dichloroethane
- aromatic hydrocarbons e.g. toluene, xylene or chlorobenzene
- ethers such as diethyl ether, methyl tert-butyl ether, tetrahydrofuran or dioxane
- polar aprotic solvents such as acetonitrile
- reaction temperature is in the range of from 0° C. up to the boiling point of the reaction mixture.
- halogating agents are phosgene, diphosgene, triphosgene, thionyl chloride, oxalyl chloride, phosphorus oxychloride, phosphorus pentachloride, mesyl chloride, chloromethylene-N,N-dimethylammonium chloride, oxalyl bromide, phosphorus oxybromide and the like.
- the starting compounds are employed in an equimolar ratio. It may also be advantageous to employ one or the other component in excess.
- Suitable solvents are chlorinated hydrcarbons such as methylene chloride or 1,2-dichloroethane, aromatic hydrocarbons, e.g. toluene, xylene or chlorobenzene, polar aprotic solvents such as acetonitrile, dimethylformamide or dimethyl sulfoxide, or mixtures of these. It is also possible to carry out the reaction without solvent.
- chlorinated hydrcarbons such as methylene chloride or 1,2-dichloroethane
- aromatic hydrocarbons e.g. toluene, xylene or chlorobenzene
- polar aprotic solvents such as acetonitrile, dimethylformamide or dimethyl sulfoxide, or mixtures of these. It is also possible to carry out the reaction without solvent.
- reaction temperature is in the range of from 0° C. up to the boiling point of the reaction mixture.
- the starting compounds are employed in an equimolar ratio. However, it may also be advantageous to employ one or the other component in excess.
- Bases which are suitable are tertiary alkylamines such as triethylamine, aromatic amines such as pyridine, alkali metal carbonates, e.g. sodium carbonate or potassium carbonate, alkali metal hydrogen carbonates such as sodium hydrogen carbonate or potassium hydrogen carbonate, alkali metal alkoxides such as sodium methoxide, sodium ethoxide or potassium tert-butoxide, or alkali metal hydrides such as e.g. sodium hydride. Sodium hydride or potassium tert-butoxide are preferably used.
- suitable solvents are chlorinated hydrocarbons such as methylene chloride or 1,2-dichloroethane, aromatic hydrocarbons, e.g. toluene, xylene or chlorobenzene, ethers such as diethyl ether, methyl tert-butyl ether, tetrahydrofuran or dioxane, polar aprotic solvents such as acetonitrile, dimethylformamide or dimethyl sulfoxide, or mixtures of these.
- chlorinated hydrocarbons such as methylene chloride or 1,2-dichloroethane
- aromatic hydrocarbons e.g. toluene, xylene or chlorobenzene
- ethers such as diethyl ether, methyl tert-butyl ether, tetrahydrofuran or dioxane
- polar aprotic solvents such as acetonitrile, dimethylformamide or dimethyl sulfoxide,
- reaction temperature is in the range of from 0° C. up to the boiling point of the reaction mixture.
- Suitable oxidants are m-chloroperbenzoic acid, peroxyacetic acid, trifluoroperoxyacetic acid, hydrogen peroxide, in the presence or absence of a catalyst such as tungstate.
- the starting compounds are employed in an equimolar ratio. It may be advantageous to employ one or the other component in excess.
- suitable solvents are chlorinated hydrocarbons such as methylene chloride or 1,2-dichloroethane, aromatic hydrocarbons, e.g. toluene, xylene or chlorobenzene, ethers such as diethyl ether, methyl tert-butyl ether, tetrahydrofuran or dioxane, polar aprotic solvents such as acetonitrile or dimethylformamide, or esters such as ethyl acetate, or mixtures of these.
- chlorinated hydrocarbons such as methylene chloride or 1,2-dichloroethane
- aromatic hydrocarbons e.g. toluene, xylene or chlorobenzene
- ethers such as diethyl ether, methyl tert-butyl ether, tetrahydrofuran or dioxane
- polar aprotic solvents such as acetonitrile or dimethylformamide
- reaction temperature is in the range of from 0° C. up to the boiling point of the reaction mixture.
- R 1 , R 2 are hydrogen, nitro, halogen, cyano, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 1 -C 6 -alkoxy, C 1 -C 6 -haloalkoxy, C 1 -C 6 -alkylthio, C 1 -C 6 -haloalkylthio, C 1 -C 6 -alkylsulfinyl, C 1 -C 6 -haloalkylsulfinyl, C 1 -C 6 -alkylsulfonyl or C 1 -C 6 -haloalkylsulfonyl;
- R 3 is hydrogen, halogen or C 1 -C 6 -alkyl
- R 4 is hydrogen or C 1 -C 4 -alkyl
- R 5 , R 6 are hydrogen, halogen, cyano, nitro, C 1 -C 4 -alkyl, C 1 -C 4 -alkoxy-C 1 -C 4 -alkyl, di(C 1 -C 4 -alkoxy)-C 1 -C 4 -alkyl, di(C 1 -C 4 -alkyl)amino-C 1 -C 4 -alkyl, di(C 1 -C 4 -alkyl)aminoimino-C 1 -C 4 -alkyl, hydroxyimino-C 1 -C 4 -alkyl, C 1 -C 6 -alkoxyimino-C 1 -C 4 -alkyl, C 1 -C 4 -alkoxycarbonyl-C 1 -C 4 -alkyl, C 1 -C 4 -alkylthio-C 1 -C 4 -alkyl, C 1 -C 4 -hal
- R 5 and R 6 together form a C 2 -C 6 -alkanediyl chain which can be mono-to tetrasubstituted by C 1 -C 4 -alkyl and/or can be interrupted by oxygen or an unsubstituted or C 1 -C 4 -alkyl-substituted nitrogen;
- R 7 is halogen, cyano, hydroxyl, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 1 -C 6 -alkoxy, C 1 -C 6 -haloalkoxy, C 1 -C 6 -alkylthio, C 1 -C 6 -haloalkylthio, C 1 -C 6 -alkylsulfinyl, C 1 -C 6 -haloalkylsulfinyl, C 1 -C 6 -alkylsulfonyl, C 1 -C 6 -haloalkylsulfonyl, amino, C 1 -C 6 -alkylamino, di(C 1 -C 6 -alkyl)amino, di(C 1 -C 4 -alkoxy)methyl, hydroxyimino-C 1 -C 4 -alkyl, C 1 -C 6 -alk
- R 8 is hydrogen, C 1 -C 4 -alkyl, C 1 -C 4 -haloalkyl, hydroxyl, C 1 -C 4 -alkoxy, C 1 -C 4 -alkoxy-C 2 -C 4 -alkoxy, C 1 -C 4 -haloalkoxy, C 3 -C 6 -alkenyloxy, C 3 -C 6 -alkynyloxy or NR 9 R 10 ;
- R 9 is hydrogen or C 1 -C 4 -alkyl
- R 10 is C 1 -C 4 -alkyl
- R 15 is hydroxyl or a radical which can be eliminated by hydrolysis.
- radicals which can be eliminated by hydrolysis are alkoxy, phenoxy, alkylthio or phenylthio radicals which can be unsubstituted or substituted, or halides, hetaryl radicals which are bound via nitrogen, or amino, imino radicals which can be unsubstituted or substituted, and the like.
- L 1 is halogen, in particular chlorine or bromine.
- L 3 is C 1 -C 6 -alkoxy.
- the 3-(4,5-dihydroisoxazol-5-yl)carbonyl halides of the formula III ⁇ ′ can be prepared in a conventional manner by reacting the 3-(4,5-dihydroisoxazol-5-yl)carboxylic acids of the formula III ⁇ with halogenating reagents such as thionyl chloride, thionyl bromide, phosgene, diphosgene, triphosgene, oxalyl chloride or oxalyl bromide.
- halogenating reagents such as thionyl chloride, thionyl bromide, phosgene, diphosgene, triphosgene, oxalyl chloride or oxalyl bromide.
- R 1 , R 2 are hydrogen, nitro, halogen, cyano, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 1 -C 6 -alkoxy, C 1 -C 6 -haloalkoxy, C 1 -C 6 -alkylthio, C 1 -C 6 -haloalkylthio, C 1 -C 6 -alkylsulfinyl, C 1 -C 6 -haloalkylsulfinyl, C 1 -C 6 -alkylsulfonyl or C 1 -C 6 -haloalkylsulfonyl;
- R 3 is hydrogen, halogen or C 1 -C 6 -alkyl
- R 4 is hydrogen or C 1 -C 4 -alkyl
- R 5 , R 6 are hydrogen, halogen, cyano, nitro, C 1 -C 4 -alkyl, C 1 -C 4 -alkoxy-C 1 -C 4 -alkyl, di(C 1 -C 4 -alkoxy)-C 1 -C 4 -alkyl, di(C 1 -C 4 -alkyl)amino-C 1 -C 4 -alkyl, di(C 1 -C 4 -alkyl)aminoimino-C 1 -C 4 -alkyl, hydroxyimino-C 1 -C 4 -alkyl, C 1 -C 6 -alkoxyimino-C 1 -C 4 -alkyl, C 1 -C 4 -alkoxycarbonyl-C 1 -C 4 -alkyl, C 1 -C 4 -alkylthio-C 1 -C 4 -alkyl, C 1 -C 4 -hal
- R 5 and R 6 together form a C 2 -C 6 -alkanediyl chain which can be mono-to tetrasubstituted by C 1 -C 4 -alkyl and/or can be interrupted by oxygen or an unsubstituted or C 1 -C 4 -alkyl-substituted nitrogen;
- R 7 is halogen, cyano, hydroxyl, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 1 -C 6 -alkoxy, C 1 -C 6 -haloalkoxy, C 1 -C 6 -alkylthio, C 1 -C 6 -haloalkylthio, C 1 -C 6 -alkylsulfinyl, C 1 -C 6 -haloalkylsulfinyl, C 1 -C 6 -alkylsulfonyl, C 1 -C 6 -haloalkylsulfonyl, amino, C 1 -C 6 -alkylamino, di(C 1 -C 6 -alkyl)amino, di(C 1 -C 4 -alkoxy)methyl, hydroxyimino-C 1 -C 4 -alkyl, C 1 -C 6 -alk
- R 8 is hydrogen, C 1 -C 4 -alkyl, C 1 -C 4 -haloalkyl, hydroxyl, C 1 -C 4 -alkoxy, C 1 -C 4 -alkoxy-C 2 -C 4 -alkoxy, C 1 -C 4 -haloalkoxy, C 3 -C 6 -alkenyloxy, C 3 -C 6 -alkynyloxy or NR 9 R 10 ;
- R 9 is hydrogen or C 1 -C 4 -alkyl
- R 10 is C 1 -C 4 -alkyl
- L 4 is halogen
- esters of the formula III ⁇ or the halogen compounds of the formula VI can be synthesized by subjecting nitrile oxides and corresponding alkenes of the formula VIII or IX to a 1,3-dipolar cycloaddition reaction.
- the nitrile oxides are generated in situ in a conventional manner.
- the starting materials used for this purpose are, for example, aldoximes (cf., for example, Houben-Weyl X5, p. 858 et seq.) or nitroalkanes (cf., for example, Houben-Weyl E5/2, p. 1594 et seq.).
- aldoximes cf., for example, Houben-Weyl X5, p. 858 et seq.
- nitroalkanes cf., for example, Houben-Weyl E5/2, p. 1594 et seq.
- the synthesis of the compounds of the formula VIII or IX is known (cf., for example, WO 98/50337 and WO 98/50366) or is carried out in analogy to processes known from the literature.
- the 3-(4,5-dihydroisoxazol-5-yl)benzoylcyclohexenones of the formula I and their agriculturally useful salts, both in the form of the isomer mixtures and in the form of the pure isomers, are suitable as herbicides.
- the herbicidal compositions comprising compounds of the formula I effect very good control of vegetation on non-crop areas, especially at high rates of application. In crops such as wheat, rice, maize, soya and cotton, they act against broad-leaved weeds and grass weeds without damaging the crop plants significantly. This effect is observed especially at low application rates.
- the compounds of the formula I or herbicidal compositions comprising them can additionally be employed in a further number of crop plants for eliminating undesired plants.
- suitable crop plants are:
- the compunds of the formula I can also be used in crops which tolerate the action of herbicides due to breeding, including recombinant methods.
- the compounds of the formula I, or the herbicidal compositions comprising them can be employed, for example, in the form of directly sprayable aqueous solutions, powders, suspensions, also highly-concentrated aqueous, oily or other suspensions or dispersions, emulsions, oil dispersions, pastes, dusts, materials for spreading or granules, by means of spraying, atomizing, dusting, spreading or pouring, or as a seed treatment or by mixing with the seed.
- the use forms depend on the intended purposes; in any case, they should guarantee the finest possible distribution of the active ingredients according to the invention.
- the herbicidal compositions comprise a herbicidally active amount of at least one compound of the formula I or of an agriculturally useful salt of I and adjuvants conventionally used for the formulation of crop protection products.
- Suitable inert auxiliaries are essentially: mineral oil fractions of medium to high boiling point such as kerosene and diesel oil, furthermore coal tar oils and oils of vegetable or animal origin, aliphatic, cyclic and aromatic hydrocarbons, e.g. paraffins, tetrahydronaphthalene, alkylated naphthalenes and their derivatives, alkylated benzenes and their derivatives, alcohols such as methanol, ethanol, propanol, butanol and cyclohexanol, ketones such as cyclohexanone, strongly polar solvents, e.g. amines such as N-methylpyrrolidone, and water.
- mineral oil fractions of medium to high boiling point such as kerosene and diesel oil, furthermore coal tar oils and oils of vegetable or animal origin, aliphatic, cyclic and aromatic hydrocarbons, e.g. paraffins, tetrahydronaphthalene, alky
- Aqueous use forms can be prepared from emulsion concentrates, suspensions, pastes, wettable powders or water-dispersable granules by adding water.
- emulsions, pastes or oil dispersions the 3-(4,5-dihydroisoxazol-5-yl)benzoylcyclohexenones, as such or dissolved in an oil or solvent, can be homogenized in water by means of wetters, tackifiers, dispersants or emulsifiers.
- concentrates composed of active substance, wetter, tackifier, dispersant or emulsifier and, if appropriate, solvent or oil which are suitable for dilution with water can be prepared from emulsion concentrates, suspensions, pastes, wettable powders or water-dispersable granules by adding water.
- Suitable surfactants are the alkali metal salts, alkaline earth metal salts and ammonium salts of aromatic sulfonic acids, e.g. ligno-, phenol-, naphthalene-and dibutylnaphthalenesulfonic acid, and of fatty acids, of alkyl- and alkylarylsulfonates, of alkyl sulfates, lauryl ether sulfates and fatty alcohol sulfates, and salts of sulfated hexa-, hepta- and octadecanols, and of fatty alcohol glycol ether, condensates of sulfonated naphthalene and its derivatives with formaldehyde, condensates of naphthalene, or of the naphthalenesulfonic acids, with phenol and formaldehyde, polyoxyethylene octylphenol
- Powders, materials for spreading and dusts can be prepared by mixing or concomitantly grinding the active substances with a solid carrier.
- Granules for example coated granules, impregnated granules and homogeneous granules, can be prepared by binding the active ingredients to solid carriers.
- Solid carriers are mineral earths such as silicas, silica gels, silicates, talc, kaolin, limestone, lime, chalk, bole, loess, clay, dolomite, diatomaceous earth, calcium sulfate, magnesium sulfate, magnesium oxide, ground synthetic materials, fertilizers such as ammonium sulfate, ammonium phosphate, ammonium nitrate, ureas and products of vegetable origin such as cereal meal, tree bark meal, wood meal and nutshell meal, cellulose powders or other solid carriers.
- the concentrations of the compounds of the formula I in the ready-to-use products can be varied within wide ranges.
- the formulations comprise approximately from 0.001 to 98% by weight, preferably 0.01 to 95% by weight, of at least one active ingredient.
- the active ingredients are employed in a purity of from 90% to 100%, preferably 95% to 100% (according to NMR spectrum).
- the compounds of the formula I or the herbicidal compositions can be applied pre-emergence, post-emergence or together with the seed of a crop plant. It is also possible to apply the compounds of the formula I or the herbicidal compositions by sowing the seed, of a crop plant, which has been pretreated with the herbicidal compositions or active ingredients. If the active ingredients are less well tolerated by certain crop plants, application techniques may be used in which the herbicidal compositions are sprayed with the aid of the spraying equipment in such a way that they come into very little contact, if any, with the leaves of the sensitive crop plants, while the active ingredients reach the leaves of undesired plants growing underneath, or the naked soil surface (post-directed, lay-by).
- the application rates of compound of the formula I are from 0.001 to 3.0, preferably from 0.01 to 1.0, kg of active substance (a.s.) per ha.
- the 3-(4,5-dihydroisoxazol-5-yl)benzoylcyclohexenones of the formula I can be mixed with a large number of representatives of other groups of active ingredients which act as herbicides or as growth regulators and applied together with these.
- Suitable components in mixtures are, for example, 1,2,4-thiadiazoles, 1,3,4-thiadiazoles, amides, aminophosphoric acid and its derivatives, aminotriazoles, anilides, aryloxy-/heteroaryloxyalkanoic acids and their derivatives, benzoic acid and its derivatives, benzothiadiazinones, 2-(hetaroyl/aroyl)-1,3-cyclohexanediones, heteroaryl aryl ketones, benzylisoxazolidinones, meta-CF 3 -phenyl derivatives, carbamates, quinolinecarboxylic acid and its derivatives, chloroacetanilides, cyclohexenone oxime ether derivatives, diazines, dichloropropionic acid and its derivatives, dihydrobenzofurans, dihydrofuran-3-ones, dinitroanilines, dinitrophenols, diphenyl ethers, dipyridyls,
- the culture containers used were plastic flower pots containing loamy sand with approximately 3.0% of humus as substrate.
- the seeds of the test plant were sown separately for each species.
- the active ingredients which were suspended or emulsified in water, were applied directly after sowing by means of finely distributing nozzles.
- the containers were irrigated gently to promote germination and growth and subsequently covered with transparent plastic hoods until the plants had rooted. This cover caused uniform germination of the test plants unless this was adversely affected by the active ingredients.
- test plants were first grown to a plant height of from 3 to 15 cm, depending on the plant habit, and only then treated with the active ingredients which had been suspended or emulsified in water. To this end, the test plants were either sown directly and grown in the same containers, or they were first grown separately as seedlings and transplanted into the test containers a few days prior to the treatment. The rate of application for the post-emergence the treatment was 125 or 62.5 g of a.s. (active substance) per ha.
- Evaluation was carried out using a scale of from 0 to 100. 100 means no emergence of the plants, or complete destruction of at least the aerial parts, and 0 means no damage or normal course of growth.
- the compound 2.4 was very effective against Brachiaria platyphylla, lambsquarters, Lamium amplexicaule, chamomile and common chickweed. Equally, the compound 2.9 controlled redroot pigweed, lambsquarters, hairy fingergrass, ladysthumb and fall panicum very efficiently under analogous conditions. Used pre-emergence at application rates of 125 or 62.5 g/ha, the compound 2.5 controls redroot pigweed, hairy fingergrass, lambsquarters and black nightshade highly efficiently.
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Abstract
The invention relates to 3-(4,5-dihydroisoxazole-5-yl)benzoylcyclohexenones of the general formula (I), wherein the variables have the following meanings: R1, R2 represents hydrogen, nitro, halogen, cyano, alkyl, haloalkyl, alkoxy, haloalkoxy, alkylthio, haloalkylthio, alkylsulfinyl, haloalkylsulfinyl, alkysulfonyl or C1-C6 haloalkylsulfonyl; R3 represents hydrogen, halogen or alkyl; R4 represents hydrogen or alkyl; R5, R6 represents hydrogen, halogen, cyano, nitro, alkyl, alkoxy, alkylthio, dialkylamino, phenyl, benzyl or carbonyl, wherein the 7 last residues can be substituted; R11 represents optionally substituted cyclohexenone that is linked in the 2 position and that carries a hydroxy residue or derivatives thereof in the 1 position. The invention further relates to the agriculturally useful salts thereof, to methods for producing the 3-(4,5-dihydroisoxazole-5-yl)benzoylcyclohexenones, to agents that contain the inventive compound, and to the use of said derivatives or agents containing them for controlling undesired plants.
Description
-
- in which the variables have the following meanings:
- R1, R2 are hydrogen, nitro, halogen, cyano, C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C6-haloalkoxy, C1-C6-alkylthio, C1-C6-haloalkylthio, C1-C6-alkylsulfinyl, C1-C6-haloalkylsulfinyl, C1-C6-alkylsulfonyl or C1-C6-haloalkylsulfonyl;
- R3 is hydrogen, halogen or C1-C6-alkyl;
- R4 is hydrogen or C1-C4-alkyl;
- R5, R6 are hydrogen, halogen, cyano, nitro, C1-C4-alkyl, C1-C4-alkoxy-C1-C4-alkyl, di(C1-C4-alkoxy) -C1-C4-alkyl, di(C1-C4-alkyl)amino-C1-C4-alkyl, di(C1-C4-alkyl)aminoimino-C1-C4-alkyl, hydroxyimino-C1-C4-alkyl, C1-C6-alkoxyimino-C1-C4-alkyl, C1-C4-alkoxycarbonyl-C1-C4-alkyl, C1-C4-alkylthio-C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-cyanoalkyl, C3-C8-cycloalkyl, C1-C4-alkoxy, C1-C4-alkoxy-C2-C4-alkoxy, C1-C4-haloalkoxy, C1-C4-alkylthio, C1-C4-haloalkylthio, di(C1-C4-alkyl)amino, COR8, phenyl or benzyl, it being possible for the two last-mentioned substituents to be partially or fully halogenated and/or to have attached to them one to three of the following groups:
- nitro, cyano, C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy or C1-C4-haloalkoxy;
- or
- R5 and R6 together form a C2-C6-alkanediyl chain which can be mono- to tetrasubstituted by C1-C4-alkyl and/or can be interrupted by oxygen or by unsubstituted or C1-C4-alkyl-substituted nitrogen;
- R7 is halogen, cyano, hydroxyl, C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C6-haloalkoxy, C1-C6-alkylthio, C1-C6-haloalkylthio, C1-C6-alkylsulfinyl, C1-C6-haloalkylsulfinyl, C1-C6-alkylsulfonyl, C1-C6-haloalkylsulfonyl, amino, C1-C6-alkylamino, di(C1-C6-alkyl)amino, di(C1-C4-alkoxy)methyl, hydroxylamino-C1-C4-alkyl, C1-C6-alkoxyimino-C1-C4-alkyl or COR8;
- R8 is hydrogen, C1-C4-alkyl, C1-C4-haloalkyl, hydroxyl, C1-C4-alkoxy, C1-C4-alkoxy-C2-C4-alkoxy, C1-C4-haloalkoxy, C3-C6-alkenyloxy, C3-C6-alkynyloxy or NR9R10;
- R9 is hydrogen or C1-C4-alkyl;
- R10 is C1-C4-alkyl;
-
- which is linked in the 2-position and where
- R12 is hydroxyl, mercapto, halogen, OR19, SR19, SOR20 or SO2R20;
- R13, R17 are hydrogen, C1-C4-alkyl, C1-C4-alkylthio or C1-C4-alkoxycarbonyl;
- R14, R16, R18 are hydrogen or C1-C4-alkyl;
- R15 is hydrogen, hydroxyl, halogen, C1-C6-alkyl, C1-C6-haloalkyl, di(C1-C6-alkoxy)methyl, (C1-C6-alkoxy) (C1-C6-alkylthio)methyl, di(C1-C6-alkylthio)methyl, C1-C6-alkoxy, C1-C6-haloalkoxy, C1-C6-alkylthio, C1-C6-haloalkylthio, C1-C6-alkoxycarbonyl, C1-C6-haloalkoxycarbonyl, 1,3-dioxolan-2-yl, 1,3-dioxan-2-yl, 1,3-oxathiolan-2-yl, 1,3-oxathian-2-yl, 1,3-dithiolan-2-yl or 1,3-dithian-2-yl, it being possible for the six last-mentioned radicals to have attached to them one, two or three substituents selected from amongst C1-C4-alkyl;
- or
- R13 and R14 or R17 and R18 together are C1-C5-alkanediyl which can have attached to it one, two or three substituents selected from amongst halogen, cyano, C1-C4-alkyl, C1-C4-haloalkyl or C1-C4-alkoxycarbonyl;
- R14 and R15 or R15 and R18 together are a chemical bond or C1-C5-alkanediyl which can have attached to it one, two or three substituents selected from amongst halogen, cyano, C1-C4-alkyl, C1-C4-haloalkyl or C1-C4-alkoxycarbonyl;
- or
- R14 and R18 together are C1-C5-alkanediyl which can have attached to it one, two or three substituents selected from amongst halogen, cyano, C1-C4-alkyl, C1-C4-haloalkyl or C1-C4-alkoxycarbonyl;
- or
- R15 and R16 together are —O—(CH2)p—O—, —O—(CH2)p—S—, —S—(CH2)p—S—, —O—(CH2)q— or —S—(CH2)q—, each of which can have attached to it one, two or three substituents selected from amongst halogen, cyano, C1-C4-alkyl, C1-C4-haloalkyl or C1-C4-alkoxycarbonyl;
- or
- R15 and R16 together are an oxygen atom;
- R19 is C1-C6-alkyl, C3-C6-alkenyl, C3-C6-haloalkenyl, C3-C6-alkynyl, C3-C6-cycloalkyl, C1-C20-alkylcarbonyl, C2-C20-alkenylcarbonyl, C2-C6-alkynylcarbonyl, C1-C6-alkoxycarbonyl, C3-C6-alkenyloxycarbonyl, C3-C6-alkynyloxycarbonyl, C1-C6-alkylthiocarbonyl, C1-C6-alkylaminocarbonyl, C3-C6-alkenylaminocarbonyl, C3-C6-alkynylaminocarbonyl, N, N-di(C1-C6-alkyl)aminocarbonyl, N—(C3-C6-alkenyl)-N—(C1-C6-alkyl)aminocarbonyl, N—(C3-C6-alkynyl)-N—(C1-C6-alkyl)aminocarbonyl, N—(C1-C6-alkoxy)-N—(C1-C6-alkyl)aminocarbonyl, N,N-di(C1-C6-alkyl)aminothiocarbonyl, C1-C6-alkoxyimino-C1-C6-alkyl, it being possible for the abovementioned alkyl, alkoxy and cycloalkyl radicals to be partially or fully halogenated and/or to have attached to them one, two or three substituents selected from amongst cyano, C1-C4-alkoxy, C1-C4-alkylthio, di(C1-C4-alkyl)amino, C1-C4-alkylcarbonyl, C1-C4-alkoxycarbonyl, C1-C4-alkoxy-C1-C4-alkoxycarbonyl, C1-C4-alkylaminocarbonyl, N,N-di(C1-C4-alkyl)aminocarbonyl or C3-C6-cycloalkyl; phenyl, phenyl-C1-C6-alkyl, phenylcarbonyl-C1-C6-alkyl, phenylcarbonyl, phenoxycarbonyl, phenoxythiocarbonyl, heterocyclyl, heterocyclyl-C1-C6-alkyl, heterocyclylcarbonyl-C1-C6-alkyl, heterocyclylcarbonyl, heterocyclyloxycarbonyl, heterocyclyloxythiocarbonyl, it being possible for the phenyl or heterocyclyl radical of the abovementioned radicals to be partially or fully halogenated and/or to have attached to it one, two or three substituents selected from amongst nitro, cyano, C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy or C1-C4-haloalkoxy;
- R20 is C1-C6-alkyl, C3-C6-alkenyl, C3-C6-haloalkenyl, C3-C6-alkynyl or C3-C6-cycloalkyl, it being possible for the abovementioned alkyl and cycloalkyl radicals to be partially or fully halogenated and/or to have attached to them one, two or three substituents selected from amongst cyano, C1-C4-alkoxy, C1-C4-alkylthio, di(C1-C4-alkyl)amino, C1-C4-alkylcarbonyl, C1-C4-alkoxycarbonyl, C1-C4-alkoxy-C1-C4-alkoxycarbonyl, C1-C4-alkylaminocarbonyl, N,N-di(C1-C4-alkyl)aminocarbonyl or C3-C6-cycloalkyl; phenyl, phenyl-C1-C6-alkyl, phenylcarbonyl-C1-C6-alkyl, heterocyclyl, heterocyclyl-C1-C6-alkyl or heterocyclylcarbonyl-C1-C6-alkyl, it being possible for the phenyl or heterocyclyl radical of the abovementioned radicals to be partially or fully halogenated and/or to have attached to it one, two or three substituents selected from amongst nitro, cyano, C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy or C1-C4-haloalkoxy;
- p is 2, 3 or 4;
- q is 1, 2, 3, 4 or 5;
- and to their agriculturally useful salts.
- The invention furthermore relates to processes for the preparation of compounds of the formula I, to compositions comprising them, and to the use of these derivatives or compositions comprising them for controlling harmful plants.
- Benzoylcyclohexenones are disclosed in the literature, for example in WO 96/26200.
- However, the herbicidal properties of the prior-art compounds and their tolerance by crop plants are only moderately satisfactory.
- It is an object of the present invention to find novel, in particular herbicidally active, compounds with improved properties.
- We have found that this object is achieved by the 3-(4,5-dihydroisoxazol-5-yl)benzoylcyclohexenones of the formula I and their herbicidal action.
- Furthermore, there have been found herbicidal compositions which comprise the compounds I and which have very good herbicidal action. Moreover, there have been found processes for the preparation of these compositions and methods of controlling undesired vegetation using the compounds I.
- Depending on the substitution pattern, the compounds of the formula I may contain one or more chiral centers, in which case they are present as enantiomer or diastereomer mixtures. The invention relates both to the pure enantiomers or diastereomers and to their mixtures.
- The compounds of the formula I can also be present in the form of their agriculturally useful salts, the type of the salt generally being of no importance. Suitable are in general the salts of those cations, or the acid addition salts of those acids, whose cations, or anions, respectively, do not adversely affect the herbicidal action of the compounds I.
- Suitable cations are, in particular, ions of the alkali metals, preferably lithium, sodium and potassium, of the alkaline earth metals, preferably calcium and magnesium, and of the transition metals, preferably manganese, copper, zinc and iron, and also ammonium, it being possible here, if desired, for one to four hydrogen atoms to be replaced by C1-C4-alkyl or hydroxy-C1-C4-alkyl and/or a phenyl or benzyl, preferably ammonium, diisopropylammonium, tetramethylammonium, tetrabutylammonium, trimethylbenzylammonium, and furthermore phosphonium ions, sulfonium ions, preferably tri(C1-C4-alkyl)sulfonium and sulfoxonium ions, preferably tri (C1-C4-alkyl)sulfoxonium.
- Anions of useful acid addition salts are mainly chloride, bromide, fluoride, hydrogensulfate, sulfate, dihydrogenphosphate, hydrogenphosphate, nitrate, hydrogencarbonate, carbonate, hexafluorosilicate, hexafluorophosphate, benzoate, and the anions of C1-C4-alkanoic acids, preferably formate, acetate, propionate and butyrate.
- The organic moieties stated for the substituents R1-R20 or as radicals on phenyl rings constitute collective terms for individual enumerations of the individual group members. All hydrocarbon chains, that is to say all alkyl, haloalkyl, cyanoalkyl, alkoxy, haloalkoxy, alkylthio, haloalkylthio, alkylsulfinyl, haloalkylsulfinyl, alkylsulfonyl, haloalkylsulfonyl, alkylcarbonyl, haloalkylcarbonyl, alkenylcarbonyl, alkynylcarbonyl, alkoxycarbonyl, haloalkoxycarbonyl, alkenyloxycarbonyl, alkynyloxycarbonyl, alkylthiocarbonyl, alkylaminocarbonyl, alkenylaminocarbonyl, alkynylaminocarbonyl, dialkylaminocarbonyl, (alkenyl) (alkyl)aminocarbonyl, (alkynyl)(alkyl)aminocarbonyl, N-alkoxy-N-alkylaminocarbonyl, N,N-dialkylaminothiocarbonyl, alkoxyalkoxycarbonyl, alkenyloxy, alkynyloxy, alkylamino, dialkylamino, alkoxyalkyl, dialkoxymethyl, (alkoxy)(alkylthio)methyl, dialkoxyalkyl, alkylthioalkyl, di(alkylthio)methyl, dialkylaminoalkyl, dialkylaminoiminoalkyl, hydroxyiminoalkyl, alkoxyiminoalkyl, alkoxycarbonylalkyl, alkoxyalkoxy, alkenyl, haloalkenyl, alkenyloxy, alkynyl and alkynyloxy moieties and the hydrocarbon chains of phenylalkyl, phenylcarbonylalkyl, heterocyclylalkyl and heterocyclylcarbonylalkyl, C1-C4-alkylaminocarbonyl, di(C1-C4-alkyl)aminocarbonyl, phenyl-C1-C4-alkyl, phenylcarbonyl-C1-C4-alkyl, heterocyclyl-C1-C4-alkyl and heterocyclylcarbonyl-C1-C4-alkyl can be straight-chain or branched. Unless otherwise specified, halogenated substituents preferably have attached to them one to five identical or different halogen atoms. The meaning halogen is in each case fluorine, chlorine, bromine or iodine.
- Other examples of meanings are:
- C1-C4-alkyl and the alkyl moieties of C1-C4-alkylcarbonyl, di(C1-C4-alkoxy)-C1-C4-alkyl, di(C1-C4-alkyl)aminoimino-C1-C4-alkyl, C1-C6-alkoxyimino-C1-C4-alkyl, hydroxyimino-C1-C4-alkyl, C1-C4-alkylaminocarbonyl, di(C1-C4-alkyl)aminocarbonyl, phenyl-C1-C4-alkyl, phenylcarbonyl-C1-C4-alkyl, heterocyclyl-C1-C4-alkyl and heterocyclylcarbonyl-C1-C4-alkyl: for example methyl, ethyl, propyl, 1-methylethyl, butyl, 1-methylpropyl, 2-methylpropyl and 1,1-dimethylethyl;
- C1-C6-alkyl and the alkyl moieties of C1-C6-alkoxyimino-C1-C6-alkyl, N—C3-C6-alkenyl-N—C1-C6-alkylaminocarbonyl, N—C1-C6-alkynyl-N—C1-C6-alkylaminocarbonyl, N—C1-C6-alkoxy-N—C1-C6-alkylaminocarbonyl, phenyl-C1-C6-alkyl, phenylcarbonyl-C1-C6-alkyl, heterocyclyl-C1-C6-alkyl and heterocyclylcarbonyl-C1-C6-alkyl: C1-C4-alkyl as mentioned above and, for example, pentyl, 1-methylbutyl, 2-methylbutyl, 3-methylbutyl, 2,2-dimethylpropyl, 1-ethylpropyl, hexyl, 1,1-dimethylpropyl, 1,2-dimethylpropyl, 1-methylpentyl, 2-methylpentyl, 3-methylpentyl, 4-methylpentyl, 1,1-dimethylbutyl, 1,2-dimethylbutyl, 1,3-dimethylbutyl, 2,2-dimethylbutyl, 2,3-dimethylbutyl, 3,3-dimethylbutyl, 1-ethylbutyl, 2-ethylbutyl, 1,1,2-trimethylpropyl, 1-ethyl-l-methylpropyl and 1-ethyl-3-methylpropyl;
- C1-C20-alkyl as alkyl moiety of C1-C20-alkylcarbonyl: C1-C6-alkyl as mentioned above and heptyl, octyl, pentadecyl or heptadecyl;
- C1-C4-haloalkyl and the haloalkyl moieties of C1-C4-haloalkylcarbonyl: a C1-C4-alkyl radical as mentioned above which is partially or fully substituted by fluorine, chlorine, bromine and/or iodine, i.e. e.g. chloromethyl, dichloromethyl, trichloromethyl, fluoromethyl, difluoromethyl, trifluoromethyl, chlorofluoromethyl, dichlorofluoromethyl, chlorodifluoromethyl, bromoethyl, iodomethyl, 1-fluoroethyl, 1-chloroethyl, 1-bromoethyl, 1-iodoethyl, 2-fluoroethyl, 2-chloroethyl, 2-bromoethyl, 2-iodoethyl, 2,2-difluoroethyl, 2,2,2-trifluoroethyl, 2-chloro-2-fluoroethyl, 2-chloro-2,2-difluoroethyl, 2,2-dichloro-2-fluoroethyl, 2,2,2-trichloroethyl, pentafluoroethyl, 2-fluoropropyl, 3-fluoropropyl, 2,2-difluoropropyl, 2,3-difluoropropyl, 2-chloropropyl, 3-chloropropyl, 2,3-dichloropropyl, 2-bromopropyl, 3-bromopropyl, 3,3,3-trifluoropropyl, 3,3,3-trichloropropyl, 2,2,3,3,3-pentafluoropropyl, heptafluoropropyl, 1-(fluoromethyl)-2-fluoroethyl, 1-(chloromethyl)-2-chloroethyl, 1-(bromomethyl)-2-bromoethyl, 4-fluorobutyl, 4-chlorobutyl, 4-bromobutyl and nonafluorobutyl;
- C1-C6-haloalkyl: C1-C4-haloalkyl as mentioned above and, for example, 5-fluoropentyl, 5-chloropentyl, 5-bromopentyl, 5-iodopentyl, undecafluoropentyl, 6-fluorohexyl, 6-chlorohexyl, 6-bromohexyl, 6-iodohexyl and dodecafluorohexyl;
- C1-C4-cyanoalkyl: for example cyanomethyl, 1-cyanoeth-1-yl, 2-cyanoeth-1-yl, 1-cyanoprop-1-yl, 2-cyanoprop-1-yl, 3-cyanoprop-1-yl, 1-cyanoprop-2-yl, 2-cyanoprop-2-yl, 1-cyanobut-1-yl, 2-cyanobut-1-yl, 3-cyanobut-1-yl, 4-cyanobut-1-yl, 1-cyanobut-2-yl, 2-cyanobut-2-yl, 1-cyanobut-3-yl, 2-cyanobut-3-yl, 1-cyano-2-methylprop-3-yl, 2-cyano-2-methylprop-3-yl, 3-cyano-2-methylprop-3-yl and 2-cyanomethylprop-2-yl;
- C3-C6-alkenyl and the alkenyl moieties of C3-C6-alkenylcarbonyl, C3-C6-alkenylaminocarbonyl, N—(C3-C6-alkenyl)-N—(C1-C6-alkyl)aminocarbonyl: prop-1-en-1-yl, prop-2-en-1-yl, 1-methylethenyl, buten-1-yl, buten-2-yl, buten-3-yl, 1-methylprop-l-en-1-yl, 2-methylprop-l-en-1-yl, 1-methylprop-2-en-1-yl, 2-methylprop-2-en-1-yl, penten-1-yl, penten-2-yl, penten-3-yl, penten-4-yl, 1-methylbut-1-en-1-yl, 2-methylbut-l-en-1-yl, 3-methylbut-1-en-1-yl, 1-methylbut-2-en-1-yl, 2-methylbut-2-en-1-yl, 3-methylbut-2-en-1-yl, 1-methylbut-3-en-1-yl, 2-methylbut-3-en-1-yl, 3-methylbut-3-en-1-yl, 1,1-dimethylprop-2-en-1-yl, 1,2-dimethylprop-1-en-1-yl, 1,2-dimethylprop-2-en-1-yl, 1-ethylprop-1-en-2-yl, 1-ethylprop-2-en-1-yl, hex-l-en-1-yl, hex-2-en-1-yl, hex-3-en-1-yl, hex-4-en-1-yl, hex-5-en-1-yl, 1-methylpent-1-en-1-yl, 2-methylpent-1-en-1-yl, 3-methylpent-1-en-1-yl, 4-methylpent-1-en-1-yl, 1-methylpent-2-en-1-yl, 2-methylpent-2-en-1-yl, 3-methylpent-2-en-1-yl, 4-methylpent-2-en-1-yl, 1-methylpent-3-en-1-yl, 2-methylpent-3-en-1-yl, 3-methylpent-3-en-1-yl, 4-methylpent-3-en-1-yl, 1-methylpent-4-en-1-yl, 2-methylpent-4-en-1-yl, 3-methylpent-4-en-1-yl, 4-methylpent-4-en-1-yl, 1,1-dimethylbut-2-en-1-yl, 1,1-dimethylbut-3-en-1-yl, 1,2-dimethylbut-1-en-1-yl, 1,2-dimethylbut-2-en-1-yl, 1,2-dimethylbut-3-en-1-yl, 1,3-dimethylbut-1-en-1-yl, 1,3-dimethylbut-2-en-1-yl, 1,3-dimethylbut-3-en-1-yl, 2,2-dimethylbut-3-en-1-yl, 2,3-dimethylbut-1-en-1-yl, 2,3-dimethylbut-2-en-1-yl, 2,3-dimethylbut-3-en-1-yl, 3,3-dimethylbut-1-en-1-yl, 3,3-dimethylbut-2-en-1-yl, 1-ethylbut-1-en-1-yl, 1-ethylbut-2-en-1-yl, 1-ethylbut-3-en-1-yl, 2-ethylbut-l-en-1-yl, 2-ethylbut-2-en-1-yl, 2-ethylbut-3-en-1-yl, 1,1,2-trimethylprop-2-en-1-yl, 1-ethyl-l-methylprop-2-en-1-yl, 1-ethyl-2-methylprop-1-en-1-yl and 1-ethyl-2-methylprop-2-en-1-yl;
- C2-C6-alkenyl as alkenyl moieties of C2-C6-alkenylcarbonyl: C3-C6-alkenyl as mentioned above, and also ethenyl;
- C2-C20-alkenyl as alkenyl moieties of C2-C20-alkenylcarbonyl: C2-C6-alkenyl as mentioned above, and also 8-pentadecen-1-yl, 8-heptadecen-1-yl and 8,11-heptadecadien-1-yl;
- C3-C6-haloalkenyl: a C3-C6-alkenyl radical as mentioned above which is partially or fully substituted by fluorine, chlorine, bromine and/or iodine, i.e. for example 2-chloroallyl, 3-chloroallyl, 2,3-dichloroallyl, 3,3-dichloroallyl, 2,3,3-trichloroallyl, 2,3-dichlorobut-2-enyl, 2-bromoallyl, 3-bromoallyl, 2,3-dibromoallyl, 3,3-dibromoallyl, 2,3,3-tribromoallyl or 2,3-dibromobut-2-enyl;
- C3-C6-alkynyl and the alkynyl moieties of C3-C6-alkynylcarbonyl, C3-C6-alkynylaminocarbonyl, N—(C3-C6-alkynyl)-N—(C1-C6-alkyl)aminocarbonyl: for example propargyl, but-1-yn-3-yl, but-1-yn-4-yl, but-2-yn-1-yl, pent-1-yn-3-yl, pent-1-yn-4-yl, pent-1-yn-5-yl, pent-2-yn-1-yl, pent-2-yn-4-yl, pent-2-yn-5-yl, 3-methylbut-1-yn-3-yl, 3-methylbut-1-yn-4-yl, hex-1-yn-3-yl, hex-1-yn-4-yl, hex-1-yn-5-yl, hex-1-yn-6-yl, hex-2-yn-1-yl, hex-2-yn-4-yl, hex-2-yn-5-yl, hex-2-yn-6-yl, hex-3-yn-1-yl, hex-3-yn-2-yl, 3-methylpent-1-yn-3-yl, 3-methylpent-1-yn-4-yl, 3-methylpent-1-yn-5-yl, 4-methylpent-2-yn-4-yl or 4-methylpent-2-yn-5-yl;
- C2-C6-alkynyl as alkynyl moiety of C2-C6-alkynylcarbonyl: C3-C6-alkynyl as mentioned above, and also ethynyl;
- C1-C4-alkoxy and the alkoxy moieties of di(C1-C4-alkoxy)methyl and di(C1-C4-alkoxy)-C1-C4-alkyl: for example methoxy, ethoxy, propoxy, 1-methylethoxy, butoxy, 1-methylpropoxy, 2-methylpropoxy and 1,1-dimethylethoxy;
- C1-C6-alkoxy and the alkoxy moieties of C1-C6-alkoxyimino-C1-C4-alkyl, C1-C6-alkoxyimino C1-C6-alkyl, N—C1-C6-alkoxy-N—C1-C6-alkylaminocarbonyl, di(C1-C6-alkoxy)methyl and (C1-C6-alkoxy) (C1-C6-alkylthio)methyl: C1-C4-alkoxy as mentioned above, and also for example pentoxy, 1-methylbutoxy, 2-methylbutoxy, 3-methoxylbutoxy, 1,1-dimethylpropoxy, 1,2-dimethylpropoxy, 2,2-dimethylpropoxy, 1-ethylpropoxy, hexoxy, 1-methylpentoxy, 2-methylpentoxy, 3-methylpentoxy, 4-methylpentoxy, 1,1-dimethylbutoxy, 1,2-dimethylbutoxy, 1,3-dimethylbutoxy, 2,2-dimethylbutoxy, 2,3-dimethylbutoxy, 3,3-dimethylbutoxy, 1-ethylbutoxy, 2-ethylbutoxy, 1,1,2-trimethylpropoxy, 1,2,2-trimethylpropoxy, 1-ethyl-1-methylpropoxy and 1-ethyl-2-methylpropoxy;
- C1-C4-haloalkoxy: a C1-C4-alkoxy radical as mentioned above which is partially or fully substituted by fluorine, chlorine, bromine and/or iodine, i.e. for example fluoromethoxy, difluoromethoxy, trifluoromethoxy, chlorodifluoromethoxy, bromodifluoromethoxy, 2-fluoroethoxy, 2-chloroethoxy, 2-bromoethoxy, 2-iodoethoxy, 2,2-difluoroethoxy, 2,2,2-trifluoroethoxy, 2-chloro-2-fluoroethoxy, 2-chloro-2,2-difluoroethoxy, 2,2-dichloro-2-fluoroethoxy, 2,2,2-trichloroethoxy, pentafluoroethoxy, 2-fluoropropoxy, 3-fluoropropoxy, 2-chloropropoxy, 3-chloropropoxy, 2-bromopropoxy, 3-bromopropoxy, 2,2-difluoropropoxy, 2,3-difluoropropoxy, 2,3-dichloropropoxy, 3,3,3-trifluoropropoxy, 3,3,3-trichloropropoxy, 2,2,3,3,3-pentafluoropropoxy, heptafluoropropoxy, 1-(fluoromethyl)-2-fluoroethoxy, 1-(chloromethyl)-2-chloroethoxy, 1-(bromomethyl)-2-bromoethoxy, 4-fluorobutoxy, 4-chlorobutoxy, 4-bromobutoxy and nonafluorobutoxy;
- C1-C6-haloalkoxy: C1-C4-haloalkoxy as mentioned above, and also for example 5-fluoropentoxy, 5-chloropentoxy, 5-bromopentoxy, 5-iodopentoxy, undecafluoropentoxy, 6-fluorohexoxy, 6-chlorohexoxy, 6-bromohexoxy, 6-iodohexoxy and dodecafluorohexoxy;
- C1-C4-alkylthio: for example methylthio, ethylthio, propylthio, 1-methylethylthio, butylthio, 1-methylpropylthio, 2-methylpropylthio and 1,1-dimethylethylthio;
- C1-C6-alkylthio and the alkylthio moieties of (C1-C6-alkoxy) (C1-C6-alkylthio)methyl, di(C1-C6-alkylthio)methyl and C1-C6-alkylthiocarbonyl: C1-C4-alkylthio as mentioned above, and also for example pentylthio, 1-methylbutylthio, 2-methylbutylthio, 3-methylbutylthio, 2,2-dimethylpropylthio, 1-ethylpropylthio, hexylthio, 1,1-dimethylpropylthio, 1,2-dimethylpropylthio, 1-methylpentylthio, 2-methylpentylthio, 3-methylpentylthio, 4-methylpentylthio, 1,1-dimethylbutylthio, 1,2-dimethylbutylthio, 1,3-dimethylbutylthio, 2,2-dimethylbutylthio, 2,3-dimethylbutylthio, 3,3-dimethylbutylthio, 1-ethylbutylthio, 2-ethylbutylthio, 1,1,2-trimethylpropylthio, 1,2,2-trimethylpropylthio, 1-ethyl-1-methylpropylthio and 1-ethyl-2-methylpropylthio;
- C1-C4-haloalkylthio: a C1-C4-alkylthio radical as mentioned above which is partially or fully substituted by fluorine, chlorine, bromine and/or iodine, i.e. for example fluoromethylthio, difluoromethylthio, trifluoromethylthio, chlorodifluoromethylthio, bromodifluoromethylthio, 2-fluoroethylthio, 2-chloroethylthio, 2-bromoethylthio, 2-iodoethylthio, 2,2-difluoroethylthio, 2,2,2-trifluoroethylthio, 2,2,2-trichloroethylthio, 2-chloro-2-fluoroethylthio, 2-chloro-2,2-difluoroethylthio, 2,2-dichloro-2-fluoroethylthio, pentafluoroethylthio, 2-fluoropropylthio, 3-fluoropropylthio, 2-chloropropylthio, 3-chloropropylthio, 2-bromopropylthio, 3-bromopropylthio, 2,2-difluoropropylthio, 2,3-difluoropropylthio, 2,3-dichloropropylthio, 3,3,3-trifluoropropylthio, 3,3,3-trichloropropylthio, 2,2,3,3,3-pentafluoropropylthio, heptafluoropropylthio, 1-(fluoromethyl)-2-fluoroethylthio, 1-(chloromethyl)-2-chloroethylthio, 1-(bromomethyl)-2-bromoethylthio, 4-fluorobutylthio, 4-chlorobutylthio, 4-bromobutylthio and nonafluorobutylthio;
- C1-C6-haloalkylthio: C1-C4-haloalkylthio as mentioned above, and also for example 5-fluoropentylthio, 5-chloropentylthio, 5-bromopentylthio, 5-iodopentylthio, undecafluoropentylthio, 6-fluorohexylthio, 6-chlorohexylthio, 6-bromohexylthio, 6-iodohexylthio and dodecafluorohexylthio;
- C1-C6-alkylsulfinyl (C1-C6-alkyl-S(═O)—): for example methylsulfinyl, ethylsulfinyl, propylsulfinyl, 1-methylethylsulfinyl, butylsulfinyl, 1-methylpropylsulfinyl, 2-methylpropylsulfinyl, 1,1-dimethylethylsulfinyl, pentylsulfinyl, 1-methylbutylsulfinyl, 2-methylbutylsulfinyl, 3-methylbutylsulfinyl, 2,2-dimethylpropylsulfinyl, 1-ethylpropylsulfinyl, 1,1-dimethylpropylsulfinyl, 1,2-dimethylpropylsulfinyl, hexylsulfinyl, 1-methylpentylsulfinyl, 2-methylpentylsulfinyl, 3-methylpentylsulfinyl, 4-methylpentylsulfinyl, 1,1-dimethylbutylsulfinyl, 1,2-dimethylbutylsulfinyl, 1,3-dimethylbutylsulfinyl, 2,2-dimethylbutylsulfinyl, 2,3-dimethylbutylsulfinyl, 3,3-dimethylbutylsulfinyl, 1-ethylbutylsulfinyl, 2-ethylbutylsulfinyl, 1,1,2-trimethylpropylsulfinyl, 1,2,2-trimethylpropylsulfinyl, 1-ethyl-1-methylpropylsulfinyl and 1-ethyl-2-methylpropylsulfinyl;
- C1-C6-haloalkylsulfinyl: C1-C6-alkylsulfinyl radical as mentioned above which is partially or fully substituted by fluorine, chlorine, bromine and/or iodine, i.e. for example fluoromethylsulfinyl, difluoromethylsulfinyl, trifluoromethylsulfinyl, chlorodifluoromethylsulfinyl, bromodifluoromethylsulfinyl, 2-fluoroethylsulfinyl, 2-chloroethylsulfinyl, 2-bromoethylsulfinyl, 2-iodoethylsulfinyl, 2,2-difluoroethylsulfinyl, 2,2,2-trifluoroethylsulfinyl, 2,2,2-trichloroethylsulfinyl, 2-chloro-2-fluoroethylsulfinyl, 2-chloro-2,2-difluoroethylsulfinyl, 2,2-dichloro-2-fluoroethylsulfinyl, pentafluoroethylsulfinyl, 2-fluoropropylsulfinyl, 3-fluoropropylsulfinyl, 2-chloropropylsulfinyl, 3-chloropropylsulfinyl, 2-bromopropylsulfinyl, 3-bromopropylsulfinyl, 2,2-difluoropropylsulfinyl, 2,3-difluoropropylsulfinyl, 2,3-dichloropropylsulfinyl, 3,3,3-trifluoropropylsulfinyl, 3,3,3-trichloropropylsulfinyl, 2,2,3,3,3-pentafluoropropylsulfinyl, heptafluoropropylsulfinyl, 1-(fluoromethyl)-2-fluoroethylsulfinyl, 1-(chloromethyl)-2-chloroethylsulfinyl, 1-(bromomethyl)-2-bromoethylsulfinyl, 4-fluorobutylsulfinyl, 4-chlorobutylsulfinyl, 4-bromobutylsulfinyl, nonafluorobutylsulfinyl, 5-fluoropentylsulfinyl, 5-chloropentylsulfinyl, 5-bromopentylsulfinyl, 5-iodopentylsulfinyl, undecafluoropentylsulfinyl, 6-fluorohexylsulfinyl, 6-chlorohexylsulfinyl, 6-bromohexylsulfinyl, 6-iodohexylsulfinyl and dodecafluorohexylsulfinyl;
- C1-C4-alkylsulfonyl (C1-C6-alkyl-S(═O)2—) : for example methylsulfonyl, ethylsulfonyl, propylsulfonyl, 1-methylethylsulfonyl, butylsulfonyl, 1-methylpropylsulfonyl, 2-methylpropylsulfonyl and 1,1-dimethylethylsulfonyl;
- C1-C6-alkylsulfonyl: C1-C4-alkylsulfonyl as mentioned above, and also for example pentylsulfonyl, 1-methylbutylsulfonyl, 2-methylbutylsulfonyl, 3-methylbutylsulfonyl, 1,1-dimethylpropylsulfonyl, 1,2-dimethylpropylsulfonyl, 2,2-dimethylpropylsulfonyl, 1-ethylpropylsulfonyl, hexylsulfonyl, 1-methylpentylsulfonyl, 2-methylpentylsulfonyl, 3-methylpentylsulfonyl, 4-methylpentylsulfonyl, 1,1-dimethylbutylsulfonyl, 1,2-dimethylbutylsulfonyl, 1,3-dimethylbutylsulfonyl, 2,2-dimethylbutylsulfonyl, 2,3-dimethylbutylsulfonyl, 3,3-dimethylbutylsulfonyl, 1-ethylbutylsulfonyl, 2-ethylbutylsulfonyl, 1,1,2-trimethylpropylsulfonyl, 1,2,2-trimethylpropylsulfonyl, 1-ethyl-1-methylpropylsulfonyl and 1-ethyl-2-methylpropylsulfonyl;
- C1-C4-haloalkylsulfonyl: a C1-C6-alkylsulfonyl radical as mentioned above which is partially or fully substituted by fluorine, chlorine, bromine and/or iodine, i.e. for example fluoromethylsulfonyl, difluoromethylsulfonyl, trifluoromethylsulfonyl, chlorodifluoromethylsulfonyl, bromodifluoromethylsulfonyl, 2-fluoroethylsulfonyl, 2-chloroethylsulfonyl, 2-bromoethylsulfonyl, 2-iodoethylsulfonyl, 2,2-difluoroethylsulfonyl, 2,2,2-trifluoroethylsulfonyl, 2-chloro-2-fluoroethylsulfonyl, 2-chloro-2,2-difluoroethylsulfonyl, 2,2-dichloro-2-fluoroethylsulfonyl, 2,2,2-trichloroethylsulfonyl, pentafluoroethylsulfonyl, 2-fluoropropylsulfonyl, 3-fluoropropylsulfonyl, 2-chloropropylsulfonyl, 3-chloropropylsulfonyl, 2-bromopropylsulfonyl, 3-bromopropylsulfonyl, 2,2-difluoropropylsulfonyl, 2,3-difluoropropylsulfonyl, 2,3-dichloropropylsulfonyl, 3,3,3-trifluoropropylsulfonyl, 3,3,3-trichloropropylsulfonyl, 2,2,3,3,3-pentafluoropropylsulfonyl, heptafluoropropylsulfonyl, 1-(fluoromethyl)-2-fluoroethylsulfonyl, 1-(chloromethyl)-2-chloroethylsulfonyl, 1-(bromomethyl)-2-bromoethylsulfonyl, 4-fluorobutylsulfonyl, 4-chlorobutylsulfonyl, 4-bromobutylsulfonyl and nonafluorobutylsulfonyl;
- C1-C6-haloalkylsulfonyl: a C1-C4-haloalkylsulfonyl radical as mentioned above, and also 5-fluoropentylsulfonyl, 5-chloropentylsulfonyl, 5-bromopentylsulfonyl, 5-iodopentylsulfonyl, 6-fluorohexylsulfonyl, 6-bromohexylsulfonyl, 6-iodohexylsulfonyl and dodecafluorohexylsulfonyl;
- C1-C4-alkoxycarbonyl: for example methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, 1-methylethoxycarbonyl, butoxycarbonyl, 1-methylpropoxycarbonyl, 2-methylpropoxycarbonyl and 1,1-dimethoxycarbonyl;
- C1-C6-alkoxycarbonyl: a C1-C4-alkoxycarbonyl radical as mentioned above, and also for example: pentoxycarbonyl, 1-methylbutoxycarbonyl, 2-methylbutoxycarbonyl, 3-methylbutoxycarbonyl, 1,1-dimethylpropoxycarbonyl, 1,2-dimethylpropoxycarbonyl, 2,2-dimethylpropoxycarbonyl, 1-ethylpropoxycarbonyl, hexoxycarbonyl, 1-methylpentoxycarbonyl, 2-methylpentoxycarbonyl, 3-methylpentoxycarbonyl, 4-methylpentoxycarbonyl, 1,1-dimethylbutoxycarbonyl, 1,2-dimethylbutoxycarbonyl, 1,3-dimethylbutoxycarbonyl, 2,2-dimethylbutoxycarbonyl, 2,3-dimethylbutoxycarbonyl, 3,3-dimethylbutoxycarbonyl, 1-ethylbutoxycarbonyl, 2-ethylbutoxycarbonyl, 1,2,2-trimethylpropoxycarbonyl, 1,2,2-trimethylpropoxycarbonyl, 1-ethyl-1-methylpropoxycarbonyl and 1-ethyl-2-methylpropoxycarbonyl;
- C1-C4-haloalkoxycarbonyl: a C1-C4-alkoxycarbonyl radical as mentioned above which is partially or fully substituted by fluorine, chlorine, bromine and/or iodine, i.e. for example fluoromethoxycarbonyl, difluoromethoxycarbonyl, trifluoromethoxycarbonyl, chlorodifluoromethoxycarbonyl, bromodifluoromethoxycarbonyl, 2-fluoroethoxycarbonyl, 2-chloroethoxycarbonyl, 2-bromoethoxycarbonyl, 2-iodoethoxycarbonyl, 2,2-difluoroethoxycarbonyl, 2,2,2-trifluoroethoxycarbonyl, 2-chloro-2-fluoroethoxycarbonyl, 2-chloro-2,2-difluoroethoxycarbonyl, 2,2-dichloro-2-fluoroethoxycarbonyl, 2,2,2-trichloroethoxycarbonyl, pentafluoroethoxycarbonyl, 2-fluoropropoxycarbonyl, 3-fluoropropoxycarbonyl, 2-chloropropoxycarbonyl, 3-chloropropoxycarbonyl, 2-bromopropoxycarbonyl, 3-bromopropoxycarbonyl, 2,2-difluoropropoxycarbonyl, 2,3-difluoropropoxycarbonyl, 2,3-dichloropropoxycarbonyl, 3,3,3-trifluoropropoxycarbonyl, 3,3,3-trichloropropoxycarbonyl, 2,2,3,3,3-pentafluoropropoxycarbonyl, heptafluoropropoxycarbonyl, 1-(fluoromethyl)-2-fluoroethoxycarbonyl, 1-(chloromethyl)-2-chloroethoxycarbonyl, 1-(bromomethyl)-2-bromoethoxycarbonyl, 4-fluorobutoxycarbonyl, 4-chlorobutoxycarbonyl, 4-bromobutoxycarbonyl and 4-iodobutoxycarbonyl;
- C1-C6-haloalkoxycarbonyl: a C1-C4-haloalkoxycarbonyl radical as mentioned above, and also 5-fluoropentoxycarbonyl, 5-chloropentoxycarbonyl, 5-bromopentoxycarbonyl, 5-iodopentoxycarbonyl, 6-fluorohexoxycarbonyl, 6-bromohexoxycarbonyl, 6-iodohexoxycarbonyl and dodecafluorohexoxycarbonyl;
- C3-C6-alkenyloxy and the C3-C6-alkenyloxy moieties of C3-C6-Alkenyloxycarbonyl: for example prop-1-en-1-yloxy, prop-2-en-1-yloxy, 1-methylethenyloxy, buten-1-yloxy, buten-2-yloxy, buten-3-yloxy, 1-methylprop-1-en-1-yloxy, 2-methylprop-1-en-1-yloxy, 1-methylprop-2-en-1-yloxy, 2-methylprop-2-en-1-yloxy, penten-1-yloxy, penten-2-yloxy, penten-3-yloxy, penten-4-yloxy, 1-methylbut-1-en-1-yloxy, 2-methylbut-1-en-1-yloxy, 3-methylbut-1-en-1-yloxy, 1-methylbut-2-en-1-yloxy, 2-methylbut-2-en-1-yloxy, 3-methylbut-2-en-1-yloxy, 1-methylbut-3-en-1-yloxy, 2-methylbut-3-en-1-yloxy, 3-methylbut-3-en-1-yloxy, 1,1-dimethylprop-2-en-1-yloxy, 1,2-dimethylprop-1-en-1-yloxy, 1,2-dimethylprop-2-en-1-yloxy, 1-ethylprop-1-en-2-yloxy, 1-ethylprop-2-en-1-yloxy, hex-1-en-1-yloxy, hex-2-en-1-yloxy, hex-3-en-1-yloxy, hex-4-en-1-yloxy, hex-5-en-1-yloxy, 1-methylpent-1-en-1-yloxy, 2-methylpent-1-en-1-yloxy, 3 -methylpent-1-en-1-yloxy, 4-methylpent-1-en-1-yloxy, 1-methylpent-2-en-1-yloxy, 2-methylpent-2-en-1-yloxy, 3-methylpent-2-en-1-yloxy, 4-methylpent-2-en-1-yloxy, 1-methylpent-3-en-1-yloxy, 2-methylpent-3-en-1-yloxy, 3-methylpent-3-en-1-yloxy, 4-methylpent-3-en-1-yloxy, 1-methylpent-4-en-1-yloxy, 2-methylpent-4-en-1-yloxy, 3-methylpent-4-en-1-yloxy, 4-methylpent-4-en-1-yloxy, 1,1-dimethylbut-2-en-1-yloxy, 1,1-dimethylbut-3-en-1-yloxy, 1,2-dimethylbut-1-en-1-yloxy, 1,2-dimethylbut-2-en-1-yloxy, 1,2-dimethylbut-3-en-1-yloxy, 1,3-dimethylbut-1-en-1-yloxy, 1,3-dimethylbut-2-en-1-yloxy, 1,3-dimethylbut-3-en-1-yloxy, 2,2-dimethylbut-3-en-1-yloxy, 2,3-dimethylbut-1-en-1-yloxy, 2,3-dimethylbut-2-en-1-yloxy, 2,3-dimethylbut-3-en-1-yloxy, 3,3-dimethylbut-1-en-1-yloxy, 3,3-dimethylbut-2-en-1-yloxy, 1-ethylbut-1-en-1-yloxy, 1-ethylbut-2-en-1-yloxy, 1-ethylbut-3-en-1-yloxy, 2-ethylbut-1-en-1-yloxy, 2-ethylbut-2-en-1-yloxy, 2-ethylbut-3-en-1-yloxy, 1,1,2-trimethylprop-2-en-1-yloxy, 1-ethyl-1-methylprop-2-en-1-yloxy, 1-ethyl-2-methylprop-1-en-1-yloxy and 1-ethyl-2-methylprop-2-en-1-yloxy;
- C3-C6-alkynyloxy and the alkynyloxy moieties of C3-C6-alkynyloxycarbonyl: for example prop-1-yn-1-yloxy, prop-2-yn-1-yloxy, but-1-yn-1-yloxy, but-1-yn-3-yloxy, but-1-yn-4-yloxy, but-2-yn-1-yloxy, pent-1-yn-1-yloxy, pent-1-yn-3-yloxy, pent-1-yn-4-yloxy, pent-1-yn-5-yloxy, pent-2-yn-1-yloxy, pent-2-yn-4-yloxy, pent-2-yn-5-yloxy, 3-methylbut-1-yn-3-yloxy, 3-methylbut-1-yn-4-yloxy, hex-1-yn-1-yloxy, hex-1-yn-3-yloxy, hex-1-yn-4-yloxy, hex-1-yn-5-yloxy, hex-1-yn-6-yloxy, hex-2-yn-1-yloxy, hex-2-yn-4-yloxy, hex-2-yn-5-yloxy, hex-2-yn-6-yloxy, hex-3-yn-1-yloxy, hex-3-yn-2-yloxy, 3-methylpent-1-yn-1-yloxy, 3-methylpent-1-yn-3-yloxy, 3-methylpent-1-yn-4-yloxy, 3-methylpent-1-yn-5-yloxy, 4-methylpent-1-yn-1-yloxy, 4-methylpent-2-yn-4-yloxy and 4-methylpent-2-yn-5-yloxy;
- C1-C6-alkylamino and the alkylamino moieties of C1-C6-alkylaminocarbonyl: for example methylamino, ethylamino, propylamino, 1-methylethylamino, butylamino, 1-methylpropylamino, 2-methylpropylamino, 1,1-dimethylethylamino, pentylamino, 1-methylbutylamino, 2-methylbutylamino, 3-methylbutylamino, 2,2-dimethylpropylamino, 1-ethylpropylamino, hexylamino, 1,1-dimethylpropylamino, 1,2-dimethylpropylamino, 1-methylpentylamino, 2-methylpentylamino, 3-methylpentylamino, 4-methylpentylamino, 1,1-dimethylbutylamino, 1,2-dimethylbutylamino, 1,3-dimethylbutylamino, 2,2-dimethylbutylamino, 2,3-dimethylbutylamino, 3,3-dimethylbutylamino, 1-ethylbutylamino, 2-ethylbutylamino, 1,1,2-trimethylpropylamino, 1,2,2-trimethylpropylamino, 1-ethyl-1-methylpropylamino or 1-ethyl-2-methylpropylamino;
- di(C1-C4-alkyl)amino and the dialkylamino moieties of di(C1-C4-alkyl)aminoimino-C1-C4-alkyl and di(C1-C4-alkyl)aminocarbonyl: for example N,N-dimethylamino, N,N-diethylamino, N,N-dipropylamino, N,N-di(1-methylethyl)amino, N,N-dibutylamino, N,N-di(1-methylpropyl)amino, N,N-di(2-methylpropyl)amino, N,N-di(1,1-dimethylethyl)amino, N-ethyl-N-methylamino, N-methyl-N-propylamino, N-methyl-N-(1-methylethyl)amino, N-butyl-N-methylamino, N-methyl-N-(1-methylpropyl)amino, N-methyl-N-(2-methylpropyl)amino, N-(1,1-dimethylethyl)-N-methylamino, N-ethyl-N-propylamino, N-ethyl-N-(1-methylethyl)amino, N-butyl-N-ethylamino, N-ethyl-N-(1-methylpropyl)amino, N-ethyl-N-(2-methylpropyl)amino, N-ethyl-N-(1,1-dimethylethyl)amino, N-(1-methylethyl)-N-propylamino, N-butyl-N-propylamino, N-(1-methylpropyl)-N-propylamino, N-(2-methylpropyl)-N-propylamino, N-(1,1-dimethylethyl)-N-propylamino, N-butyl-N-(1-methylethyl)amino, N-(1-methylethyl)-N-(1-methylpropyl)amino, N-(1-methylethyl)-N-(2-methylpropyl)amino, N-(1,1-dimethylethyl)-N-(1-methylethyl)amino, N-butyl-N-(1-methylpropyl)amino, N-butyl-N-(2-methylpropyl)amino, N-butyl-N-(1,1-dimethylethyl)amino, N-(1-methylpropyl)-N-(2-methylpropyl)amino, N-(1,1-dimethylethyl)-N-(1-methylpropyl)amino and N-(1,1-dimethylethyl)-N-(2-methylpropyl)amino;
- di(C1-C6-alkyl)amino and the dialkylamino moieties of di(C1-C6-alkyl)aminocarbonyl and di(C1-C6-alkyl)aminothiocarbonyl: di(C1-C4-alkyl)amino as mentioned above, and also N,N-dipentylamino, N,N-dihexylamino, N-methyl-N-pentylamino, N-ethyl-N-pentylamino, N-methyl-N-hexylamino or N-ethyl-N-hexylamino;
- di(C1-C4-alkyl)amino-C1-C4-alkyl: C1-C4-alkyl substituted by di(C1-C4-alkyl)amino as mentioned above, i.e., for example, N,N-dimethylaminomethyl, N,N-diethylaminomethyl, N,N-dipropylaminomethyl, N,N-di(1-methylethyl)aminomethyl, N,N-dibutylaminomethyl, N,N-di(1-methylpropyl)aminomethyl, N,N-di(2-methylpropyl)aminomethyl, N,N-di(1,1-dimethylethyl)aminomethyl, N-ethyl-N-methylaminomethyl, N-methyl-N-propylaminomethyl, N-methyl-N-(1-methylethyl)aminomethyl, N-butyl-N-methylaminomethyl, N-methyl-N-(1-methylpropyl)aminomethyl, N-methyl-N-(2-methylpropyl)aminomethyl, N-(1,1-dimethylethyl)-N-methylaminomethyl, N-ethyl-N-propylaminomethyl, N-ethyl-N-(1-methylethyl)aminomethyl, N-butyl-N-ethylaminomethyl, N-ethyl-N-(1-methylpropyl)aminomethyl, N-ethyl-N-(2-methylpropyl)aminomethyl, N-ethyl-N-(1,1-dimethylethyl)aminomethyl, N-(1-methylethyl)-N-propylaminomethyl, N-butyl-N-propylaminomethyl, N-(1-methylpropyl)-N-propylaminomethyl, N-(2-methylpropyl)-N-propylaminomethyl, N-(1,1-dimethylethyl)-N-propylaminomethyl, N-butyl-N-(1-methylethyl)aminomethyl, N-(1-methylethyl)-N-(1-methylpropyl)aminomethyl, N-(1-methylethyl)-N-(2-methylpropyl)aminomethyl, N-(1,1-dimethylethyl)-N-(1-methylethyl)aminomethyl, N-butyl-N-(1-methylpropyl)aminomethyl, N-butyl-N-(2-methylpropyl)aminomethyl, N-butyl-N-(1,1-dimethylethyl)aminomethyl, N-(1-methylpropyl)-N-(2-methylpropyl)aminomethyl, N-(1,1-dimethylethyl)-N-(1-methylpropyl)aminomethyl, N-(1,1-dimethylethyl)-N-(2-methylpropyl)aminomethyl, 2-(N,N-dimethylamino)ethyl, 2-(N,N-diethylamino)ethyl, 2-(N,N-dipropylamino)ethyl, 2-[N,N-di-(1-methylethyl)amino]ethyl, 2-[N,N-dibutylamino]ethyl, 2-[N,N-di(1-methylpropyl)amino]ethyl, 2-[N,N-di(2-methylpropyl)amino]ethyl, 2-[N,N-di(1,l-dimethylethyl)amino]ethyl, 2-[N-ethyl-N-methylamino]ethyl, 2-[N-methyl-N-propylamino]ethyl, 2-[N-methyl-N-(1-methylethyl)amino]ethyl, 2-[N-butyl-N-methylamino]ethyl, 2-[N-methyl-N-(1-methylpropyl)amino]ethyl, 2-[N-methyl-N-(2-methylpropyl)amino]ethyl, 2-[N-(1,1-dimethylethyl)-N-methylamino]ethyl, 2-[N-ethyl-N-propylamino]ethyl, 2-[N-ethyl-N-(1-methylethyl)amino]ethyl, 2-[N-butyl-N-ethylamino]ethyl, 2-[N-ethyl-N-(1-methylpropyl)amino]ethyl, 2-[N-ethyl-N-(2-methylpropyl)amino]ethyl, 2-[N-ethyl-N-(1,1-dimethylethylamino]ethyl, 2-[N-(1-methylethyl)-N-propylamino]ethyl, 2-[N-Butyl-N-propylamino]ethyl, 2-[N-(1-methylpropyl)-N-propylamino]ethyl, 2-[N-(2-methylpropyl)-N-propylamino]ethyl, 2-[N-(1,1-dimethylethyl)-N-propylamino]ethyl, 2-[N-butyl-N-(1-methylethyl)amino]ethyl, 2-[N-(1-methylethyl)-N-(1-methylpropyl)amino]ethyl, 2-[N-(1-methylethyl)-N-(2-methylpropyl)amino]ethyl, 2-[N-(1, 1-dimethylethyl) -N-(1-methylethyl)amino]ethyl, 2-[N-butyl-N-(1-methylpropyl)amino]ethyl, 2-[N-butyl-N-(2-methylpropyl)amino]ethyl, 2-[N-butyl-N-(1,1-dimethylethyl)amino]ethyl, 2-[N-(1-methylpropyl)-N-(2-methylpropyl)amino]ethyl, 2-[N-(1,1-dimethylethyl)-N-(1-methylpropyl)amino]ethyl, 2-[N-(1,1-dimethylethyl)-N-(2-methylpropyl)amino]ethyl, 3-(N,N-dimethylamino)propyl, 3-(N,N-diethylamino)propyl, 4-(N,N-dimethylamino)butyl and 4-(N,N-diethylamino)butyl;
- C1-C4-alkoxy-C1-C4-alkyl: C1-C4-alkyl substituted by C1-C4-alkoxy as mentioned above, i.e., for example, methoxymethyl, ethoxymethyl, propoxymethyl, (1-methylethoxy)methyl, butoxymethyl, (1-methylpropoxy)methyl, (2-methylpropoxy)methyl, (1,1-dimethylethoxy)methyl, 2-(methoxy)ethyl, 2-(ethoxy)ethyl, 2-(Propoxy)ethyl, 2-(1-methylethoxy)ethyl, 2-(butoxy) ethyl, 2-(1-methylpropoxy) ethyl, 2-(2-methylpropoxy)ethyl, 2-(1,1-dimethylethoxy)ethyl, 2-(methoxy)propyl, 2-(ethoxy)propyl, 2-(propoxy)propyl, 2-(1-methylethoxy)propyl, 2-(butoxy)propyl, 2-(1-methylpropoxy)propyl, 2-(2-methylpropoxy)propyl, 2-(1,1-dimethylethoxy)propyl, 3-(methoxy)propyl, 3-(ethoxy)propyl, 3-(propoxy)propyl, 3-(1-methylethoxy)propyl, 3-(butoxy)propyl, 3-(1-methylpropoxy)propyl, 3-(2-methylpropoxy)propyl, 3-(1,1-dimethylethoxy)propyl, 2-(methoxy)butyl, 2-(ethoxy)butyl, 2-(propoxy)butyl, 2-(1-methylethoxy)butyl, 2-(butoxy)butyl, 2-(1-methylpropoxy)butyl, 2-(2-methylpropoxy)butyl, 2-(1,1-dimethylethoxy)butyl, 3-(methoxy)butyl, 3-(ethoxy)butyl, 3-(propoxy)butyl, 3-(1-methylethoxy)butyl, 3-(butoxy)butyl, 3-(1-methylpropoxy)butyl, 3-(2-methylpropoxy)butyl, 3-(1,1-dimethylethoxy)butyl, 4-(methoxy)butyl, 4-(ethoxy)butyl, 4-(propoxy)butyl, 4-(1-methylethoxy)butyl, 4-(butoxy)butyl, 4-(1-methylpropoxy)butyl, 4-(2-methylpropoxy)butyl and 4-(1,1-dimethylethoxy)butyl;
- C1-C4-alkylthio-C1-C4-alkyl: C1-C4-alkyl substituted by C1-C4-alkylthio as mentioned above, i.e., for example, methylthiomethyl, ethylthiomethyl, propylthiomethyl, (1-methylethylthio)methyl, butylthiomethyl, (1-methylpropylthio)methyl, (2-methylpropylthio)methyl, (1,1-dimethylethylthio)methyl, 2-methylthioethyl, 2-ethylthioethyl, 2-(propylthio)ethyl, 2-(1-methylethylthio)ethyl, 2-(butylthio)ethyl, 2-(1-methylpropylthio) ethyl, 2-(2-methylpropylthio)ethyl, 2-(1,1-dimethylethylthio)ethyl, 2-(methylthio)propyl, 3-(methylthio)propyl, 2-(ethylthio)propyl, 3-(ethylthio)propyl, 3-(propylthio)propyl, 3-(butylthio)propyl, 4-(methylthio)butyl, 4-(ethylthio)butyl, 4-(propylthio)butyl and 4-(butylthio)butyl;
- C1-C4-alkoxycarbonyl-C1-C4-alkyl: C1-C4-alkyl substituted by C1-C4-alkoxycarbonyl, i.e., for example, methoxycarbonylmethyl, ethoxycarbonylmethyl, propoxycarbonylmethyl, (1-methylethoxycarbonyl)methyl, butoxycarbonylmethyl, (1-methylpropoxycarbonyl)methyl, (2-methylpropoxycarbonyl)methyl, (1,1-dimethylethoxycarbonyl)methyl, 2-(methoxycarbonyl)ethyl, 2-(ethoxycarbonyl)ethyl, 2-(propoxycarbonyl)ethyl, 2-(1-methylethoxycarbonyl)ethyl, 2-(butoxycarbonyl)ethyl, 2-(1-methylpropoxycarbonyl)ethyl, 2-(2-methylpropoxycarbonyl)ethyl, 2-(1,1-dimethylethoxycarbonyl)ethyl, 2-(methoxycarbonyl)propyl, 2-(ethoxycarbonyl)propyl, 2-(propoxycarbonyl)propyl, 2-(1-methylethoxycarbonyl)propyl, 2-(butoxycarbonyl)propyl, 2-(1-methylpropoxycarbonyl)propyl, 2-(2-methylpropoxycarbonyl)propyl, 2-(1,1-dimethylethoxycarbonyl)propyl, 3-(methoxycarbonyl)propyl, 3-(ethoxycarbonyl)propyl, 3-(propoxycarbonyl)propyl, 3-(1-methylethoxycarbonyl)propyl, 3-(butoxycarbonyl)propyl, 3-(1-methylpropoxycarbonyl)propyl, 3-(2-methylpropoxycarbonyl)propyl, 3-(1,1-dimethylethoxycarbonyl)propyl, 2-(methoxycarbonyl)butyl, 2-(ethoxycarbonyl)butyl, 2-(propoxycarbonyl)butyl, 2-(1-methylethoxycarbonyl)butyl, 2-(butoxycarbonyl)butyl, 2-(1-methylpropoxycarbonyl)butyl, 2-(2-methylpropoxycarbonyl)butyl, 2-(1,1-dimethylethoxycarbonyl)butyl, 3-(methoxycarbonyl)butyl, 3-(ethoxycarbonyl)butyl, 3-(propoxycarbonyl)butyl, 3-(1-methylethoxycarbonyl)butyl, 3-(butoxycarbonyl)butyl, 3-(1-methylpropoxycarbonyl)butyl, 3-(2-methylpropoxycarbonyl)butyl, 3-(1,1-dimethylethoxycarbonyl)butyl, 4-(methoxycarbonyl)butyl, 4-(ethoxycarbonyl)butyl, 4-(propoxycarbonyl)butyl, 4-(1-methylethoxycarbonyl)butyl, 4-(butoxycarbonyl)butyl, 4-(1-methylpropoxy)butoxy, 4-(2-methylpropoxy)butoxy and 4-(1,1-dimethylethoxycarbonyl)butyl;
- C1-C4-alkoxy-C2-C4-alkoxy: C2-C4-alkoxy substituted by C1-C4-alkoxy as mentioned above, i.e., for example, 2-(methoxy)ethoxy, 2-(ethoxy)ethoxy, 2-(propoxy)ethoxy, 2-(1-methylethoxy)ethoxy, 2-(butoxy)ethoxy, 2-(1-methylpropoxy)ethoxy, 2-(2-methylpropoxy)ethoxy, 2-(1,1-dimethylethoxy)ethoxy, 2-(methoxy)propoxy, 2-(ethoxy)propoxy, 2-(propoxy)propoxy, 2-(1-methylethoxy)propoxy, 2-(butoxy)propoxy, 2-(1-methylpropoxy)propoxy, 2-(2-methylpropoxy)propoxy, 2-(1,1-dimethylethoxy)propoxy, 3-(methoxy)propoxy, 3-(ethoxy)propoxy, 3-(propoxy)propoxy, 3-(i-methylethoxy)propoxy, 3-(butoxy)propoxy, 3-(1-methylpropoxy)propoxy, 3-(2-methylpropoxy)propoxy, 3-(1,1-dimethylethoxy)propoxy, 2-(methoxy)butoxy, 2-(ethoxy)butoxy, 2-(propoxy)butoxy, 2-(1-methylethoxy)butoxy, 2-(butoxy)butoxy, 2-(1-methylpropoxy)butoxy, 2-(2-methylpropoxy)butoxy, 2-(1,1-dimethylethoxy)butoxy, 3-(methoxy)butoxy, 3-(ethoxy)butoxy, 3-(propoxy)butoxy, 3-(1-methylethoxy)butoxy, 3-(butoxy)butoxy, 3-(1-methylpropoxy)butoxy, 3-(2-methylpropoxy)butoxy, 3-(1,1-dimethylethoxy)butoxy, 4-(methoxy)butoxy, 4-(ethoxy)butoxy, 4-(propoxy)butoxy, 4-(1-methylethoxy)butoxy, 4-(butoxy)butoxy, 4-(1-methylpropoxy)butoxy, 4-(2-methylpropoxy)butoxy and 4-(1,1-dimethylethoxy)butoxy;
- C2-C5-alkanediyl: for example ethane-1,2-diyl, propane-1,3-diyl, butane-1,4-diyl and pentane-1,5-diyl;
- C1-C5-alkanediyl: C2-C5-alkanediyl as mentioned above, and also methanediyl;
- C2-C6-alkanediyl: C2-C5-alkanediyl as mentioned above, and also hexane-1,6-diyl;
- C3-C6-cycloalkyl: for example cyclopropyl, cyclobutyl, cyclopentyl and cyclohexyl;
- C3-C8-cycloalkyl: C3-C6-cycloalkyl as mentioned above, and also cycloheptyl and cyclooctyl;
- heterocyclyl and heterocyclyl moieties of heterocyclylcarbonyl, heterocyclyl-C1-C6-alkyl, heterocyclylcarbonyl-C1-C6-alkyl: a saturated, partially saturated or unsaturated 5- or 6-membered heterocyclic ring which contains one to four identical or different hetero atoms selected from the following group: oxygen, sulfur or nitrogen, i.e., for example, 5-membered saturated rings such as:
- tetrahydrofuran-2-yl, tetrahydrofuran-3-yl, tetrahydrothien-2-yl, tetrahydrothien-3-yl, tetrahydropyrrol-2-yl, tetrahydropyrrol-3-yl, tetrahydropyrazol-3-yl, tetrahydropyrazol-4-yl, tetrahydroisoxazol-3-yl, tetrahydroisoxazol-4-yl, tetrahydroisoxazol-5-yl, 1,2-oxathiolan-3-yl, 1,2-oxathiolan-4-yl, 1,2-oxathiolan-5-yl, tetrahydroisothiazol-3-yl, tetrahydroisothiazol-4-yl, tetrahydroisothiazol-5-yl, 1,2-dithiolan-3-yl, 1,2-dithiolan-4-yl, tetrahydroimidazol-2-yl, tetrahydroimidazol-4-yl, tetrahydrooxazol-2-yl, tetrahydrooxazol-4-yl, tetrahydrooxazol-5-yl, tetrahydrothiazol-2-yl, tetrahydrothiazol-4-yl, tetrahydrothiazol-5-yl, 1,3-dioxolan-2-yl, 1,3-dioxolan-4-yl, 1,3-oxathiolan-2-yl, 1,3-oxathiolan-4-yl, 1,3-oxathiolan-5-yl, 1,3-dithiolan-2-yl, 1,3-dithiolan-4-yl, 1,3,2-dioxathiolan-4-yl;
- 5-membered partially saturated rings such as:
- 2,3-dihydrofuran-2-yl, 2,3-dihydrofuran-3-yl, 2,5-dihydrofuran-2-yl, 2,5-dihydrofuran-3-yl, 4,5-dihydrofuran-2-yl, 4,5-dihydrofuran-3-yl, 2,3-dihydrothien-2-yl, 2,3-dihydrothien-3-yl, 2,5-dihydrothien-2-yl, 2,5-dihydrothien-3-yl, 4,5-dihydrothien-2-yl, 4,5-dihydrothien-3-yl, 2,3-dihydro-1H-pyrrol-2-yl, 2,3-dihydro-1H-pyrrol-3-yl, 2,5-dihydro-1H-pyrrol-2-yl, 2,5-dihydro-1H-pyrrol-3-yl, 4,5-dihydro-1H-pyrrol-2-yl, 4,5-dihydro-1H-pyrrol-3-yl, 3,4-dihydro-2H-pyrrol-2-yl, 3,4-dihydro-2H-pyrrol-3-yl, 3,4-dihydro-5H-pyrrol-2-yl, 3,4-dihydro-5H-pyrrol-3-yl, 4,5-dihydro-1H-pyrazol-3-yl, 4,5-dihydro-1H-pyrazol-4-yl, 4,5-dihydro-1H-pyrazol-5-yl, 2,5-dihydro-1H-pyrazol-3-yl, 2,5-dihydro-1H-pyrazol-4-yl, 2,5-dihydro-1H-pyrazol-5-yl, 4,5-dihydroisoxazol-3-yl, 4,5-dihydroisoxazol-4-yl, 4,5-dihydroisoxazol-5-yl, 2,5-dihydroisoxazol-3-yl, 2,5-dihydroisoxazol-4-yl, 2,5-dihydroisoxazol-5-yl, 2,3-dihydroisoxazol-3-yl, 2,3-dihydroisoxazol-4-yl, 2,3-dihydroisoxazol-5-yl, 4,5-dihydroisothiazol-3-yl, 4,5-dihydroisothiazol-4-yl, 4,5-dihydroisothiazol-5-yl, 2,5-dihydroisothiazol-3-yl, 2,5-dihydroisothiazol-4-yl, 2,5-dihydroisothiazol-5-yl, 2,3-dihydroisothiazol-3-yl, 2,3-dihydroisothiazol-4-yl, 2,3-dihydroisothiazol-5-yl, Δ3-1,2-dithiol-3-yl, Δ3-1,2-dithiol-4-yl, Δ3-1,2-dithiol-5-yl, 4,5-dihydro-1H-imidazol-2-yl, 4,5-dihydro-1H-imidazol-4-yl, 4,5-dihydro-1H-imidazol-5-yl, 2,5-dihydro-1H-imidazol-2-yl, 2,5-dihydro-1H-imidazol-4-yl, 2,5-dihydro-1H-imidazol-5-yl, 2,3-dihydro-1H-imidazol-2-yl, 2,3-dihydro-1H-imidazol-4-yl, 4,5-dihydrooxazol-2-yl, 4,5-dihydrooxazol-4-yl, 4,5-dihydrooxazol-5-yl, 2,5-dihydrooxazol-2-yl, 2,5-dihydrooxazol-4-yl, 2,5-dihydrooxazol-5-yl, 2,3-dihydrooxazol-2-yl, 2,3-dihydrooxazol-4-yl, 2,3-dihydrooxazol-5-yl, 4,5-dihydrothiazol-2-yl, 4,5-dihydrothiazol-4-yl, 4,5-dihydrothiazol-5-yl, 2,5-dihydrothiazol-2-yl, 2,5-dihydrothiazol-4-yl, 2,5-dihydrothiazol-5-yl, 2,3-dihydrothiazol-2-yl, 2,3-dihydrothiazol-4-yl, 2,3-dihydrothiazol-5-yl, 1,3-dioxol-2-yl, 1,3-dioxol-4-yl, 1,3-dithiol-2-yl, 1,3-dithiol-4-yl, 1,3-oxathiol-2-yl, 1,3-oxathiol-4-yl, 1,3-oxathiol-5-yl, 1,2,3-Δ2-oxadiazolin-4-yl, 1,2,3-Δ2-oxadiazolin-5-yl, 1,2,4-Δ4-oxadiazolin-3-yl, 1,2,4-Δ4-oxadiazolin-5-yl, 1,2,4-Δ2-oxadiazolin-3-yl, 1,2,4-Δ2-oxadiazolin-5-yl, 1,2,4-Δ3-oxadiazolin-3-yl, 1,2,4-Δ3-oxadiazolin-5-yl, 1,3,4-Δ2-oxadiazolin-2-yl, 1,3,4-Δ2-oxadiazolin-5-yl, 1,3,4-Δ3-oxadiazolin-2-yl, 1,3,4-oxadiazolin-2-yl, 1,2,4-Δ4-thiadiazolin-3-yl, 1,2,4-Δ4-thiadiazolin-5-yl, 1,2,4-Δ3-thiadiazolin-3-yl, 1,2,4-Δ3-thiadiazolin-5-yl, 1,2,4-Δ2-thiadiazolin-3-yl, 1,2,4-Δ2-thiadiazolin-5-yl, 1,3,4-Δ2-thiadiazolin-2-yl, 1,3,4-Δ2-thiadiazolin-5-yl, 1,3,4-Δ3-thiadiazolin-2-yl, 1,3,4-thiadiazolin-2-yl, 1,2,3-Δ2-triazolin-4-yl, 1,2,3-Δ2-triazolin-5-yl, 1,2,4-Δ2-triazolin-3-yl, 1,2,4-Δ2-triazolin-5-yl, 1,2,4-Δ3-triazolin-3-yl, 1,2,4-Δ3-triazolin-5-yl, 1,2,4-Δ1-triazolin-2-yl, 1,2,4-triazolin-3-yl, 3H-1,2,4-dithiazol-5-yl, 2H-1,3,4-dithiazol-5-yl, 2H-1,3,4-oxathiazol-5-yl;
- 5-membered, unsaturated rings such as:
- 2-furyl, 3-furyl, 2-thienyl, 3-thienyl, pyrrol-2-yl, pyrrol-3-yl, pyrazol-3-yl, pyrazol-4-yl, isoxazol-3-yl, isoxazol-4-yl, isoxazol-5-yl, isothiazol-3-yl, isothiazol-4-yl, isothiazol-5-yl, imidazol-2-yl, imidazol-4-yl, oxazol-2-yl, oxazol-4-yl, oxazol-5-yl, thiazol-2-yl, thiazol-4-yl, thiazol-5-yl, 1,2,3-oxadiazol-4-yl, 1,2,3-oxadiazol-5-yl, 1,2,4-oxadiazol-3-yl, 1,2,4,-oxadiazol-5-yl, 1,3,4-oxadiazol-2-yl, 1,2,3-thiadiazol-4-yl, 1,2,3-thiadiazol-5-yl, 1,2,4-thiadiazol-3-yl, 1,2,4-thiadiazol-5-yl, 1,3,4-thiadiazolyl-2-yl, 1,2,3-triazol-4-yl, 1,2,4-triazol-3-yl, tetrazol-5-yl;
- 6-membered saturated rings such as:
- tetrahydropyran-2-yl, tetrahydropyran-3-yl, tetrahydropyran-4-yl, piperidin-2-yl, piperidin-3-yl, piperidin-4-yl, tetrahydrothiopyran-2-yl, tetrahydrothiopyran-3-yl, tetrahydrothiopyran-4-yl, 1,3-dioxan-2-yl, 1,3-dioxan-4-yl, 1,3-dioxan-5-yl, 1,4-dioxan-2-yl, 1,3-dithian-2-yl, 1,3-dithian-4-yl, 1,3-dithian-5-yl, 1,4-dithian-2-yl, 1,3-oxathian-2-yl, 1,3-oxathian-4-yl, 1,3-oxathian-5-yl, 1,3-oxathian-6-yl, 1,4-oxathian-2-yl, 1,4-oxathian-3-yl, 1,2-dithian-3-yl, 1,2-dithian-4-yl, hexahydropyrimidin-2-yl, hexahydropyrimidin-4-yl, hexahydropyrimidin-5-yl, hexahydropyrazin-2-yl, hexahydropyridazin-3-yl, hexahydropyridazin-4-yl, tetrahydro-1,3-oxazin-2-yl, tetrahydro-1,3-oxazin-4-yl, tetrahydro-1,3-oxazin-5-yl, tetrahydro-1,3-oxazin-6-yl, tetrahydro-1,3-thiazin-2-yl, tetrahydro-1,3-thiazin-4-yl, tetrahydro-1,3-thiazin-5-yl, tetrahydro-1,3-thiazin-6-yl, tetrahydro-1,4-thiazin-2-yl, tetrahydro-1,4-thiazin-3-yl, tetrahydro-1,4-oxazin-2-yl, tetrahydro-1,4-oxazin-3-yl, tetrahydro-1,2-oxazin-3-yl, tetrahydro-1,2-oxazin-4-yl, tetrahydro-1,2-oxazin-5-yl, tetrahydro-1,2-oxazin-6-yl;
- 6-membered partially saturated rings such as:
- 2H-3,4-dihydropyran-6-yl, 2H-3,4-dihydropyran-5-yl, 2H-3,4-dihydropyran-4-yl, 2H-3,4-dihydropyran-3-yl, 2H-3,4-dihydropyran-2-yl, 2H-3,4-dihydropyran-6-yl, 2H-3,4-dihydrothiopyran-5-yl, 2H-3,4-dihydrothiopyran-4-yl, 2H-3,4-dihydropyran-3-yl, 2H-3,4-dihydropyran-2-yl, 1,2,3,4-tetrahydropyridin-6-yl, 1,2,3,4-tetrahydropyridin-5-yl, 1,2,3,4-tetrahydropyridin-4-yl, 1,2,3,4-tetrahydropyridin-3-yl, 1,2,3,4-tetrahydropyridin-2-yl, 2H-5,6-dihydropyran-2-yl, 2H-5,6-dihydropyran-3-yl, 2H-5,6-dihydropyran-4-yl, 2H-5,6-dihydropyran-5-yl, 2H-5,6-dihydropyran-6-yl, 2H-5,6-dihydrothiopyran-2-yl, 2H-5,6-dihydrothiopyran-3-yl, 2H-5,6-dihydrothiopyran-4-yl, 2H-5,6-dihydrothiopyran-5-yl, 2H-5,6-dihydrothiopyran-6-yl, 1,2,5,6-tetrahydropyridin-2-yl, 1,2,5,6-tetrahydropyridin-3-yl, 1,2,5,6-tetrahydropyridin-4-yl, 1,2,5,6-tetrahydropyridin-5-yl, 1,2,5,6-tetrahydropyridin-6-yl, 2,3,4,5-tetrahydropyridin-2-yl, 2,3,4,5-tetrahydropyridin-3-yl, 2,3,4,5-tetrahydropyridin-4-yl, 2,3,4,5-tetrahydropyridin-5-yl, 2,3,4,5-tetrahydropyridin-6-yl, 4H-pyran-2-yl, 4H-pyran-3-yl, 4H-pyran-4-yl, 4H-thiopyran-2-yl, 4H-thiopyran-3-yl, 4H-thiopyran-4-yl, 1,4-dihydropyridin-2-yl, 1,4-dihydropyridin-3-yl, 1,4-dihydropyridin-4-yl, 2H-pyran-2-yl, 2H-pyran-3-yl, 2H-pyran-4-yl, 2H-pyran-5-yl, 2H-pyran-6-yl, 2H-thiopyran-2-yl, 2H-thiopyran-3-yl, 2H-thiopyran-4-yl, 2H-thiopyran-5-yl, 2H-thiopyran-6-yl, 1,2-dihydropyridin-2-yl, 1,2-dihydropyridin-3-yl, 1,2-dihydropyridin-4-yl, 1,2-dihydropyridin-5-yl, 1,2-dihydropyridin-6-yl, 3,4-dihydropyridin-2-yl, 3,4-dihydropyridin-3-yl, 3,4-dihydropyridin-4-yl, 3,4-dihydropyridin-5-yl, 3,4-dihydropyridin-6-yl, 2,5-dihydropyridin-2-yl, 2,5-dihydropyridin-3-yl, 2,5-dihydropyridin-4-yl, 2,5-dihydropyridin-5-yl, 2,5-dihydropyridin-6-yl, 2,3-dihydropyridin-2-yl, 2,3-dihydropyridin-3-yl, 2,3-dihydropyridin-4-yl, 2,3-dihydropyridin-5-yl, 2,3-dihydropyridin-6-yl, 2H-5,6-dihydro-1,2-oxazin-3-yl, 2H-5,6-dihydro-1,2-oxazin-4-yl, 2H-5,6-dihydro-1,2-oxazin-5-yl, 2H-5,6-dihydro-1,2-oxazin-6-yl, 2H-5,6-dihydro-1,2-thiazin-3-yl, 2H-5,6-dihydro-1,2-thiazin-4-yl, 2H-5,6-dihydro-1,2-thiazin-5-yl, 2H-5,6-dihydro-1,2-thiazin-6-yl, 4H-5,6-dihydro-1,2-oxazin-3-yl, 4H-5,6-dihydro-1,2-oxazin-4-yl, 4H-5,6-dihydro-1,2-oxazin-5-yl, 4H-5,6-dihydro-1,2-oxazin-6-yl, 4H-5,6-dihydro-1,2-thiazin-3-yl, 4H-5,6-dihydro-1,2-thiazin-4-yl, 4H-5,6-dihydro-1,2-thiazin-5-yl, 4H-5,6-dihydro-1,2-thiazin-6-yl, 2H-3,6-dihydro-1,2-oxazin-3-yl, 2H-3,6-dihydro-1,2-oxazin-4-yl, 2H-3,6-dihydro-1,2-oxazin-5-yl, 2H-3,6-dihydro-1,2-oxazin-6-yl, 2H-3,6-dihydro-1,2-thiazin-3-yl, 2H-3,6-dihydro-1,2-thiazin-4-yl, 2H-3,6-dihydro-1,2-thiazin-5-yl, 2H-3,6-dihydro-1,2-thiazin-6-yl, 2H-3,4-dihydro-1,2-oxazin-3-yl, 2H-3,4-dihydro-1,2-oxazin-4-yl, 2H-3,4-dihydro-1,2-oxazin-5-yl, 2H-3,4-dihydro-1,2-oxazin-6-yl, 2H-3,4-dihydro-1,2-thiazin-3-yl, 2H-3,4-dihydro-1,2-thiazin-4-yl, 2H-3,4-dihydro-1,2-thiazin-5-yl, 2H-3,4-dihydro-1,2-thiazin-6-yl, 2,3,4,5-tetrahydropyridazin-3-yl, 2,3,4,5-tetrahydropyridazin-4-yl, 2,3,4,5-tetrahydropyridazin-5-yl, 2,3,4,5-tetrahydropyridazin-6-yl, 3,4,5,6-tetrahydropyridazin-3-yl, 3,4,5,6-tetrahydropyridazin-4-yl, 1,2,5,6-tetrahydropyridazin-3-yl, 1,2,5,6-tetrahydropyridazin-4-yl, 1,2,5,6-tetrahydropyridazin-5-yl, 1,2,5,6-tetrahydropyridazin-6-yl, 1,2,3,6-tetrahydropyridazin-3-yl, 1,2,3,6-tetrahydropyridazin-4-yl, 4H-5,6-dihydro-1,3-oxazin-2-yl, 4H-5,6-dihydro-1,3-oxazin-4-yl, 4H-5,6-dihydro-1,3-oxazin-5-yl, 4H-5,6-dihydro-1,3-oxazin-6-yl, 4H-5,6-dihydro-1,3-thiazin-2-yl, 4H-5,6-dihydro-1,3-thiazin-4-yl, 4H-5,6-dihydro-1,3-thiazin-5-yl, 4H-5,6-dihydro-1,3-thiazin-6-yl, 3,4,5,6-tetrahydropyrimidin-2-yl, 3,4,5,6-tetrahydropyrimidin-4-yl, 3,4,5,6-tetrahydropyrimidin-5-yl, 3,4,5,6-tetrahydropyrimidin-6-yl, 1,2,3,4-tetrahydropyrazin-2-yl, 1,2,3,4-tetrahydropyrazin-5-yl, 1,2,3,4-tetrahydropyrimidin-2-yl, 1,2,3,4-tetrahydropyrimidin-4-yl, 1,2,3,4-tetrahydropyrimidin-5-yl, 1,2,3,4-tetrahydropyrimidin-6-yl, 2,3-dihydro-1,4-thiazin-2-yl, 2,3-dihydro-1,4-thiazin-3-yl, 2,3-dihydro-1,4-thiazin-5-yl, 2,3-dihydro-1,4-thiazin-6-yl, 2H-1,2-oxazin-3-yl, 2H-1,2-oxazin-4-yl, 2H-1,2-oxazin-5-yl, 2H-1,2-oxazin-6-yl, 2H-1,2-thiazin-3-yl, 2H-1,2-thiazin-4-yl, 2H-1,2-thiazin-5-yl, 2H-1,2-thiazin-6-yl, 4H-1,2-oxazin-3-yl, 4H-1,2-oxazin-4-yl, 4H-1,2-oxazin-5-yl, 4H-1,2-oxazin-6-yl, 4H-1,2-thiazin-3-yl, 4H-1,2-thiazin-4-yl, 4H-1,2-thiazin-5-yl, 4H-1,2-thiazin-6-yl, 6H-1,2-oxazin-3-yl, 6H-1,2-oxazin-4-yl, 6H-1,2-oxazin-5-yl, 6H-1,2-oxazin-6-yl, 6H-1,2-thiazin-3-yl, 6H-1,2-thiazin-4-yl, 6H-1,2-thiazin-5-yl, 6H-1,2-thiazin-6-yl, 2H-1,3-oxazin-2-yl, 2H-1,3-oxazin-4-yl, 2H-1,3-oxazin-5-yl, 2H-1,3-oxazin-6-yl, 2H-1,3-thiazin-2-yl, 2H-1,3-thiazin-4-yl, 2H-1,3-thiazin-5-yl, 2H-1,3-thiazin-6-yl, 4H-1,3-oxazin-2-yl, 4H-1,3-oxazin-4-yl, 4H-1,3-oxazin-5-yl, 4H-1,3-oxazin-6-yl, 4H-1,3-thiazin-2-yl, 4H-1,3-thiazin-4-yl, 4H-1,3-thiazin-5-yl, 4H-1,3-thiazin-6-yl, 6H-1,3-oxazin-2-yl, 6H-1,3-oxazin-4-yl, 6H-1,3-oxazin-5-yl, 6H-1,3-oxazin-6-yl, 6H-1,3-thiazin-2-yl, 6H-1,3-oxazin-4-yl, 6H-1,3-oxazin-5-yl, 6H-1,3-thiazin-6-yl, 2H-1,4-oxazin-2-yl, 2H-1,4-oxazin-3-yl, 2H-1,4-oxazin-5-yl, 2H-1,4-oxazin-6-yl, 2H-1,4-thiazin-2-yl, 2H-1,4-thiazin-3-yl, 2H-1,4-thiazin-5-yl, 2H-1,4-thiazin-6-yl, 4H-1,4-oxazin-2-yl, 4H-1,4-oxazin-3-yl, 4H-1,4-thiazin-2-yl, 4H-1,4-thiazin-3-yl, 1,4-dihydropyridazin-3-yl, 1,4-dihydropyridazin-4-yl, 1,4-dihydropyridazin-5-yl, 1,4-dihydropyridazin-6-yl, 1,4-dihydropyrazin-2-yl, 1,2-dihydropyrazin-2-yl, 1,2-dihydropyrazin-3-yl, 1,2-dihydropyrazin-5-yl, 1,2-dihydropyrazin-6-yl, 1,4-dihydropyrimidin-2-yl, 1,4-dihydropyrimidin-4-yl, 1,4-dihydropyrimidin-5-yl, 1,4-dihydropyrimidin-6-yl, 3,4-dihydropyrimidin-2-yl, 3,4-dihydropyrimidin-4-yl, 3,4-dihydropyrimidin-5-yl or 3,4-dihydropyrimidin-6-yl;
- 6-membered unsaturated rings such as:
- pyridin-2-yl, pyridin-3-yl, pyridin-4-yl, pyridazin-3-yl, pyridazin-4-yl, pyrimidin-2-yl, pyrimidin-4-yl, pyrimidin-5-yl, pyrazin-2-yl, 1,3,5-triazin-2-yl, 1,2,4-triazin-3-yl, 1,2,4-triazin-5-yl, 1,2,4-triazin-6-yl, 1,2,4,5-tetrazin-3-yl;
- it optionally being possible for the sulfur of the abovementioned heterocycles to be oxidized to S═O or S(═O)2
- and it being possible for a bicyclic ring system to be formed with a fused phenyl ring or with a C3-C6-carbocycle or with a further 5- to 6-membered heterocycle.
- The following heterocyclyl radicals are preferably used:
- 5-membered unsaturated rings as mentioned above, in particular 2-furyl, 3-furyl, 2-thienyl, 3-thienyl, pyrrol-2-yl, pyrrol-3-yl, pyrazol-3-yl, pyrazol-4-yl, isoxazol-3-yl, isoxazol-4-yl, isoxazol-5-yl, imidazol-2-yl, imidazol-4-yl, oxazol-2-yl, oxazol-4-yl, oxazol-5-yl, thiazol-2-yl, thiazol-4-yl, thiazol-5-yl or 1,2,4-triazol-3-yl;
- 6-membered unsaturated rings as mentioned above, in particular pyridin-2-yl, pyridin-3-yl, pyridin-4-yl, pyrimidin-2-yl, pyrimidin-4-yl, pyrimidin-5-yl, pyrazin-2-yl or 1,3,5-triazin-2-yl;
- all phenyl or heterocyclyl rings are preferably unsubstituted or have attached to them one to three halogen atoms and/or one nitro group, one cyano radical and/or one or two methyl, trifluoromethyl, methoxy or trifluoromethoxy substituents.
- In view of the use of the compounds of the formula I according to the invention as herbicides, the variables preferably have the following meanings, in each case alone or in combination:
- R1, R2 are nitro, halogen, cyano, C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C6-haloalkoxy, C1-C6-alkylthio, C1-C6-haloalkylthio, C1-C6-alkylsulfinyl, C1-C6-haloalkylsulfinyl, C1-C6-alkylsulfonyl or C1-C6-haloalkylsulfonyl;
- especially preferably nitro, halogen such as, for example, chlorine and bromine, C1-C6-alkyl such as, for example, methyl and ethyl, C1-C6-alkoxy such as, for example, methoxy and ethoxy, C1-C6-haloalkyl such as, for example, difluoromethyl and trifluoromethyl, C1-C6-alkylthio such as, for example, methylthio and ethylthio, C1-C6-alkylsulfinyl such as, for example, methylsulfinyl and ethylsulfinyl, C1-C6-alkylsulfonyl such as, for example, methylsulfonyl, ethylsulfonyl and propylsulfonyl or C1-C6-haloalkylsulfonyl such as, for example, trifluoromethylsulfonyl and pentafluoroethylsulfonyl;
- R3 is hydrogen;
- R4 is hydrogen;
- R5, R6 are hydrogen, halogen, cyano, nitro, C1-C4-alkyl, C1-C4-alkoxy-C1-C4-alkyl, C1-C4-alkoxycarbonyl-C1-C4-alkyl, C1-C4-alkylthio-C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-cyanoalkyl, C3-C8-cycloalkyl, C1-C4-alkoxy, C1-C4-alkoxy-C2-C4-alkoxy, C1-C4-haloalkoxy, C1-C4-alkylthio, C1-C4-haloalkylthio, di(C1-C4-alkyl)amino, COR8, phenyl or benzyl, it being possible for the two last-mentioned substituents to be partially or fully halogenated and/or to have attached to them one to three of the following groups:
- nitro, cyano, C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy or C1-C4-haloalkoxy;
- or
- R5 and R6 together form a C2-C6-alkanediyl chain which can be mono- to tetrasubstituted by C1-C4-alkyl and/or can be interrupted by oxygen or an unsubstituted or C1-C4-alkyl-substituted nitrogen;
- R5 is especially preferably hydrogen, halogen, cyano, nitro, C1-C4-alkyl, C1-C4-alkoxy-C1-C4-alkyl, C1-C4-alkoxycarbonyl-C1-C4-alkyl, C1-C4-alkylthio-C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-cyanoalkyl, C3-C8-cycloalkyl, C1-C4-alkoxy, C1-C4-alkoxy-C2-C4-alkoxy, C1-C4-haloalkoxy, C1-C4-alkylthio, C1-C4-haloalkylthio, di(C1-C4-alkyl)amino, COR8, phenyl or benzyl, it being possible for the two last-mentioned substituents to be partially or fully halogenated and/or to have attached to them one to three of the following groups:
- nitro, cyano, C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy or C1-C4-haloalkoxy;
- R6 is especially preferably hydrogen or C1-C4-alkyl; particularly preferably R5 is hydrogen, C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxycarbonyl or CONR9R10;
- particularly preferably R6 is hydrogen or C1-C4-alkyl; very especially preferably R5 is hydrogen or C1-C4-alkyl, particularly hydrogen;
- very especially preferably R6 is hydrogen;
- R7 is halogen, C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C6-alkylthio, C1-C6-alkylsulfinyl, C1-C6-alkylsulfonyl, amino, C1-C6-alkylamino, di(C1-C6-alkyl)amino, di(C1-C4-alkoxy)methyl or COR8;
- especially preferably C1-C4-alkyl such as, for example, methyl, ethyl, 1-methylethyl or 1,1-dimethylethyl, C1-C4-alkylcarbonyl such as, for example, methylcarbonyl or ethylcarbonyl, hydroxycarbonyl or C1-C4-alkoxycarbonyl such as, for example, methoxycarbonyl or ethoxycarbonyl;
- particularly preferably C1-C4-alkyl such as, for example, methyl, ethyl, 1-methylethyl or 1,1-dimethylethyl, hydroxycarbonyl or C1-C4-alkoxycarbonyl;
- very especially preferably C1-C4-alkyl such as, for example, methyl, ethyl, 1-methylethyl or 1,1-dimethylethyl;
- R8 is C1-C4-alkyl, hydroxyl, C1-C4-alkoxy or NR9R10;
- R9 is hydrogen or C1-C4-alkyl;
- R10 is C1-C4-alkyl;
- R12 is hydroxyl, OR19, SR19, SOR20 or SO2R20;
- particularly hydroxyl, OR19 or SR19;
- especially preferably hydroxyl;
- R13, R17 are hydrogen, C1-C4-alkyl or C1-C4-alkylthio;
- particularly hydrogen, methyl or methylthio;
- especially preferably hydrogen or methyl, particularly preferably hydrogen;
- R14, R16, R18 are hydrogen or methyl;
- R15 is hydrogen, hydroxyl, C1-C6-alkyl or di(C1-C6-alkoxy)methyl;
- particularly hydrogen or C1-C4-alkyl;
- or
- R13 and R14 or R14 and R15 or R15 and R18 or R14 and R18 or R17 and R18 together are C1-C5-alkanediyl which can have attached to it one, two or three substituents selected from among halogen, cyano, C1-C4-alkyl, C1-C4-haloalkyl or C1-C4-alkoxycarbonyl;
- or
- R15 and R16 together are an oxygen atom;
- R19 is C1-C6-alkyl, C1-C20-alkylcarbonyl, preferably C1-C6-alkylcarbonyl, C1-C6-alkoxycarbonyl, C1-C6-alkylthiocarbonyl, it being possible for the abovementioned alkyl and alkoxy radicals to be partially or fully halogenated and/or to have attached to them one, two or three substituents selected from among cyano, C1-C4-alkoxy, C1-C4-alkylthio, C1-C4-alkylcarbonyl, C1-C4-alkoxycarbonyl or C3-C6-cycloalkyl;
- phenyl, phenyl-C1-C4-alkyl, phenylcarbonyl-C1-C4-alkyl, phenylcarbonyl, phenoxycarbonyl, heterocyclyl, heterocyclyl-C1-C4-alkyl, heterocyclylcarbonyl-C1-C4-alkyl, heterocyclyloxycarbonyl, it being possible for the phenyl or heterocyclyl radical of the abovementioned radicals to be partially or fully halogenated and/or to have attached to it one, two or three substituents selected from among nitro, cyano, C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy or C1-C4-haloalkoxy;
- R20 is C1-C6-alkyl which can be partially or fully halogenated and/or can have attached to it one, two or three substituents selected from among cyano, C1-C4-alkoxy, C1-C4-alkylthio, C1-C4-alkylcarbonyl, C1-C4-alkoxycarbonyl or C3-C6-cycloalkyl; phenyl, phenyl-C1-C4-alkyl, phenylcarbonyl-C1-C4-alkyl, heterocyclyl, heterocyclyl-C1-C4-alkyl or heterocyclylcarbonyl-C1-C4-alkyl, it being possible for the phenyl or heterocyclyl radical of the abovementioned radicals to be partially or fully halogenated and/or to have attached to it one, two or three substituents selected from among nitro, cyano, C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy or C1-C4-haloalkoxy.
- The following embodiments of the 3-(4,5-dihydroisoxazol-5-yl)benzoylcyclohexenones of the formula I must be emphasized:
- 1. In a preferred embodiment of the 3-(4,5-dihydroisoxazol-5-yl)benzoylcyclohexenones of the formula I,
- R1 is nitro, halogen, C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-alkoxy or C1-C6-haloalkoxy;
- especially preferably nitro, halogen such as chlorine or bromine, C1-C4-alkyl such as methyl or ethyl, C1-C4-haloalkyl such as difluoromethyl or trifluoromethyl, C1-C4-alkoxy such as methoxy or ethoxy, or C1-C4-haloalkoxy such as difluoromethoxy or trifluoromethoxy;
- particularly preferably halogen such as chlorine or bromine, C1-C4-alkyl such as methyl or ethyl or C1-C4-alkoxy such as methoxy or ethoxy;
- very especially preferably halogen, such as chlorine or bromine or C1-C4-alkyl such as methyl or ethyl;
- R2 is halogen, C1-C6-haloalkyl, C1-C6-alkylthio, C1-C6-haloalkylthio, C1-C6-alkylsulfinyl, C1-C6-haloalkylsulfinyl, C1-C6-alkylsulfonyl or C1-C6-haloalkylsulfonyl;
- especially preferably halogen such as fluorine or chlorine, C1-C4-haloalkyl such as difluoromethyl or trifluoromethyl, or C1-C4-alkylsulfonyl such as methylsulfonyl or ethylsulfonyl;
- particularly preferably halogen such as fluorine or chlorine, or C1-C4-alkylsulfonyl such as methylsulfonyl or ethylsulfonyl;
- very especially preferably C1-C4-alkylsulfonyl such as methylsulfonyl or ethylsulfonyl;
- 2. In a further preferred embodiment of the 3-(4,5-dihydroisoxazol-5-yl)benzoylcyclohexenones of the formula I,
- R3 is hydrogen.
- 3. In a further preferred embodiment of the 3-(4,5-dihydroisoxazol-5-yl)benzoylcyclohexenones of the formula I,
- R3 is halogen or C1-C4-alkyl;
- particularly preferably chlorine or methyl.
- 4. In a further embodiment of the 3-(4,5-dihydroisoxazol-5-yl)benzoylcyclohexenones of the formula I,
- R4 is hydrogen.
- 5. In a further embodiment of the 3-(4,5-dihydroisoxazol-5-yl)benzoylcyclohexenones of the formula I,
- R4 is hydrogen;
- R5 is hydrogen, halogen, cyano, nitro, C1-C4-alkyl, C1-C4-alkoxy-C1-C4-alkyl, C1-C4-alkoxycarbonyl-C1-C4-alkyl, C1-C4-alkylthio-C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-cyanoalkyl, C3-C8-cycloalkyl, C1-C4-alkoxy, C1-C4-alkoxy-C2-C4-alkoxy, C1-C4-haloalkoxy, C1-C4-alkylthio, C1-C4-haloalkylthio, di(C1-C4-alkyl)amino, C1-C4-alkylcarbonyl, C1-C4-alkoxycarbonyl, CONR9R10, phenyl or benzyl, it being possible for the two last-mentioned substituents to be partially or fully halogenated and/or to have attached to them one to three of the following groups:
- nitro, cyano, C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy or C1-C4-haloalkoxy;
- especially preferably hydrogen, C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxycarbonyl or CONR9R10;
- particularly preferably hydrogen or C1-C4-alkyl such as methyl or ethyl;
- very especially preferably hydrogen;
- R6 is hydrogen or C1-C4-alkyl such as methyl or ethyl;
- especially preferably hydrogen.
- 6. In a further preferred embodiment of the 3-(4,5-dihydroisoxazol-5-yl)benzoylcyclohexenones of the formula I,
- R7 is halogen, C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C6-alkylthio, C1-C6-alkylsulfinyl, C1-C6-alkylsulfonyl, amino, C1-C6-alkylamino, di(C1-C6-alkyl)amino, di(C1-C6-alkoxy)methyl, formyl, C1-C4-alkylcarbonyl, C1-C4-haloalkylcarbonyl, hydroxycarbonyl, C1-C4-alkoxycarbonyl, C1-C4-haloalkoxycarbonyl or CONR9R10;
- especially preferably halogen such as chlorine or bromine, C1-C4-alkyl such as methyl, ethyl, 1-methylethyl or 1,1-dimethylethyl, C1-C4-alkoxy, such as methoxy or ethoxy, C1-C4-alkylthio such as methylthio or ethylthio, C1-C4-alkylsulfinyl such as methylsulfinyl or ethylsulfinyl, C1-C4-alkylsulfonyl such as methylsulfonyl or ethylsulfonyl, amino, C1-C4-alkylamino such as methylamino or ethylamino, di(C1-C4-alkyl)amino such as dimethylamino or diethylamino, di(C1-C4-alkoxy)methyl such as dimethoxymethyl or diethoxymethyl, C1-C4-alkylcarbonyl such as methylcarbonyl or ethylcarbonyl, hydroxycarbonyl, C1-C4-alkoxycarbonyl such as methoxycarbonyl or ethoxycarbonyl or CONR9R10;
- particularly preferably C1-C4-alkyl such as methyl, ethyl, 1-methylethyl or 1,1-dimethylethyl, C1-C4-alkylcarbonyl such as methylcarbonyl or ethylcarbonyl, hydroxycarbonyl or C1-C4-alkoxycarbonyl such as methoxycarbonyl or ethoxycarbonyl;
- very especially preferably C1-C4-alkyl such as methyl, ethyl, 1-methylethyl or 1,1-dimethylethyl, hydroxycarbonyl or C1-C4-alkoxycarbonyl or ethoxycarbonyl;
- very particularly preferably C1-C4-alkyl such as methyl, ethyl, 1-methylethyl or 1,1-dimethylethyl.
- 7. In a further preferred embodiment of the 3-(4,5-dihydroisoxazol-5-yl)benzoylcyclohexenones of the formula I,
- R12 is hydroxyl, OR19 or SR19; and
- R19 is C1-C6-alkyl, C1-C20-alkylcarbonyl, C1-C6-alkoxycarbonyl, C1-C6-alkylthiocarbonyl, it being possible for the alkyl and alkoxy radicals to be partially or fully halogenated and/or to have attached to them one, two or three substituents selected from among cyano, C1-C4-alkoxy, C1-C4-alkylthio, C1-C4-alkylcarbonyl, C1-C4-alkoxycarbonyl or C3-C6-cycloalkyl;
- phenyl, phenyl-C1-C4-alkyl, phenylcarbonyl-C1-C4-alkyl, phenylcarbonyl, phenoxycarbonyl, heterocyclyl, heterocyclyl-C1-C4-alkyl, heterocyclylcarbonyl-C1-C4-alkyl, heterocyclyloxycarbonyl, it being possible for the phenyl or heterocyclyl radical of the abovementioned radicals to be partially or fully halogenated and/or to have attached to it one, two or three substituents selected from among nitro, cyano, C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy or C1-C4-haloalkoxy.
- Heterocyclyl (alone or in combination) is preferably a 5-membered unsaturated ring or a 6-membered unsaturated ring, in particular pyridin-2-yl or pyridin-3-yl.
- Especially preferably heterocyclyl (alone or in combination) is 5-membered unsaturated rings wth a hetero atom such as 2-furyl, 3-furyl, 2-thienyl, 3-thienyl, pyrrol-2-yl or pyrrol-3-yl;
- very especially preferably heterocyclyl is 2-thienyl or 3-thienyl.
- 8. In a further preferred embodiment of the 3-(4,5-dihydroisoxazol-5-yl)benzoylcyclohexenones of the formula I, R12 is hydroxyl.
- 9. In a further preferred embodiment of the 3-(4,5-dihydroisoxazol-5-yl)benzoylcyclohexenones of the formula I,
- R13 and R17 are hydrogen, C1-C4-alkyl or C1-C4-alkylthio;
- R14, R16, R18 are hydrogen or methyl;
- R15 is hydrogen, hydroxyl, C1-C6-alkyl or di(C1-C6-alkoxy)methyl;
- or
- R13 and R14 or R14 and R15 or R15 and R16 or R14 and R18 or R17 and R18 together are C1-C5-alkanediyl which can have attached to it one, two or three substituents selected from among halogen, cyano, C1-C4-alkyl, C1-C4-haloalkyl or C1-C4-alkoxycarbonyl;
- or
- R15 and R16 together are an oxygen atom.
- Particularly preferably,
- R13, R17 are hydrogen or C1-C4-alkyl;
- R14, R16, R18 are hydrogen or methyl;
- R15 is hydrogen, C1-C6-alkyl or di(C1-C6-alkoxy)methyl;
- very especially preferably hydrogen or C1-C6-alkyl;
- or
- R14 and R18 together are C1-C5-alkanediyl which can have attached to it one, two or three substituents selected from among halogen, cyano, C1-C4-alkyl, C1-C4-haloalkyl or C1-C4-alkoxycarbonyl;
- or
- R15 and R16 together are an oxygen atom.
- Very particularly especially preferred are the 3-(4,5-dihydroisoxazol-5-yl)benzoylcyclohexenones of the formula Ia1(≡I where R1═Cl; R2═SO2CH3; R3, R4, R15 to R18═H; R12═OH), in particular the compounds Ia1.1 to Ia1.64, the definitions of radicals R1 to R14 having a special meaning for the compounds according to the invention, not only in combination with each other, but also in each case by themselves.
TABLE 1 Ia1 No. R5 R6 R7 Ia1.l H H CH3 Ia1.2 Cl H CH3 Ia1.3 Br H CH3 Ia1.4 CN H CH3 Ia1.5 NO2 H CH3 Ia1.6 CH3 H CH3 Ia1.7 CH2CH3 H CH3 Ia1.8 CH(CH3)2 H CH3 Ia1.9 C(CH3)3 H CH3 Ia1.10 CHO H CH3 Ia1.11 CH═NOH H CH3 Ia1.12 CH═NOCH3 H CH3 Ia1.13 CH═NOCH2CH3 H CH3 Ia1.14 COCH3 H CH3 Ia1.15 C(═NOH)CH3 H CH3 Ia1.16 C(═NOCH3)CH3 H CH3 Ia1.17 C(═NOCH2CH3)CH3 H CH3 Ia1.18 CH═NN(CH3)2 H CH3 Ia1.19 C[═NN(CH3)2]CH3 H CH3 Ia1.20 COOH H CH3 Ia1.21 COOCH3 H CH3 Ia1.22 COOCH2CH3 H CH3 Ia1.23 OCH3 H CH3 Ia1.24 OCH2CH3 H CH3 Ia1.25 SCH3 H CH3 Ia1.26 CH2F H CH3 Ia1.27 CHF2 H CH3 Ia1.28 CF3 H CH3 Ia1.29 CF2CF3 H CH3 Ia1.30 CH2Cl H CH3 Ia1.31 CH2CN H CH3 la1.32 CH2—CH2 CH3 Ia1.33 CH2—CH2—CH2 CH3 la1.34 CH2—CH2—CH2—CH2 CH3 la1.35 CH2—CH2—CH2—CH2—CH2 CH3 Ia1.36 CH3 CH3 CH3 Ia1.37 CH3 CH2CH3 CH3 Ia1.38 CF3 COCH3 CH3 Ia1.39 CF3 COOCH3 CH3 Ia1.40 CN COCH3 CH3 Ia1.41 CN COOCH3 CH3 Ia1.42 CN CN CH3 Ia1.43 COCH3 COCH3 CH3 Ia1.44 COCH3 COOCH3 CH3 Ia1.45 H H CH2CH3 Ia1.46 H H CH(CH3)2 Ia1.47 H H C(CH3)3 Ia1.48 H H Cl Ia1.49 H H OCH3 Ia1.50 H H SCH3 Ia1.51 H H SOCH3 Ia1.52 H H SO2CH3 Ia1.53 H H CN Ia1.54 H H CHO Ia1.55 H H CH═NOH Ia1.56 H H CH═NOCH3 Ia1.57 H H CH═NOCH2CH3 Ia1.58 H H COCH3 Ia1.59 H H C(═NOH)CH3 Ia1.60 H H C(═NOCH3)CH3 Ia1.61 H H COOH Ia1.62 H H COOCH3 Ia1.63 H H COOCH2CH3 Ia1.64 H H CH(OCH2CH3)2 -
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- In a further preferred embodiment of the compounds of the formula I, the variables, either alone or in combination, have the following meanings:
- R1 is halogen, C1-C6-alkyl or C1-C6-alkoxy;
- preferably halogen such as chlorine or bromine, C1-C4-alkyl such as methyl, ethyl or propyl, C1-C4-alkoxy such as methoxy or ethoxy;
- especially preferably chlorine, methyl or methoxy;
- R2 is halogen or C1-C6-alkylsulfonyl;
- preferably halogen such as chlorine or bromine or C1-C4-alkylsulfonyl such as methylsulfonyl or ethylsulfonyl;
- especially preferably chlorine or methylsulfonyl;
- R3 is hydrogen;
- R hu4 is hydrogen;
- R5 is hydrogen;
- R6 is hydrogen;
- R7 is C1-C6-alkyl, C1-C4-alkylcarbonyl or C1-C4-alkoxycarbonyl; preferably C1-C6-alkyl such as methyl, ethyl, 1-methylethyl or 1,1-dimethylethyl, methylcarbonyl or ethylcarbonyl, methoxycarbonyl or ethoxycarbonyl;
- R12 is hydroxyl;
- R13 is hydrogen or C1-C4-alkyl;
- R14 is hydrogen or C1-C4-alkyl;
- R15 is hydrogen or C1-C4-alkyl;
- R16 is hydrogen or C1-C4-alkyl;
- R17 is hydrogen or C1-C4-alkyl;
- R18 is hydrogen or C1-C4-alkyl;
- or
- R15 and R16 together are an oxygen atom;
- or
- R14 and R18 together are C1-C5-alkanediyl, in particular 1,2-ethanediyl.
- The 3-(4,5-dihydroisoxazol-5-yl)benzoylcyclohexenones of the formula I can be obtained by various routes, for example by the following process:
- Process A:
-
- L1 is a nucleophilically displaceable leaving group such as halogen, e.g. bromine or chlorine, hetaryl, e.g. imidazolyl or pyridyl, carboxylate, e.g. acetate, trifluoroacetate and the like.
- The activated carboxylic acid can be employed directly, such as in the case of the carbonyl halides, or generated in situ, for example with dicyclohexylcarbodiimide, triphenylphosphane/azodicarboxylic ester, 2-pyridine disulfide/triphenylphosphane, carbonyldiimidazole and the like.
- If appropriate, it may be advantageous to carry out the acylation reaction in the presence of a base. The reactants and the auxiliary base are expediently employed in equimolar amounts. An excess of the auxiliary base, for example 1.2 to 2.5 mol equivalents, especially 1.2 to 1.5 mol equivalents, based on II, may be advantageous under certain circumstances.
- Auxiliary bases which are suitable are tertiary alkylamines, pyridine or alkali metal carbonates. Solvents which can be employed are, for example, chlorinated hydrocarbons such as methylene chloride, 1,2-dichloroethane, aromatic hydrocarbons such as toluene, xylene, chlorobenzene, ethers such as diethyl ether, methyl tert-butyl ether, tetrahydrofuran, dioxane, polar aprotic solvents such as acetonitrile, dimethylformamide, dimethyl sulfoxide, or esters such as ethyl acetate, or mixtures of these.
- If carbonyl halides are employed as activated carboxylic acid component, it may be advantageous to cool the reaction mixture to 0-10° C. when adding this reactant. The mixture is subsequently stirred at 20-100° C., preferably at 25-50° C., until the reaction is complete. Work-up is carried out in the customary fashion, for example the reaction mixture is poured into water and the product of interest is extracted. Solvents which are suitable for this purpose are in particular methylene chloride, diethyl ether and ethyl acetate. After the organic phase has been dried and the solvent has been removed, the crude ester can be employed without further purification in the rearrangement reaction.
- Rearrangement of the esters to give the compounds of the formula I is expediently carried out at temperatures of from 20 to 40° C. in a solvent and in the presence of a base and, if appropriate, with the aid of a cyano compound as catalyst.
- Solvents which can be used are, for example, acetonitrile, methylene chloride, 1,2-dichloroethane, dioxane, ethyl acetate, toluene or mixtures of these. Preferred solvents are acetonitrile and dioxane.
- Suitable bases are tertiary amines such as triethylamine, pyridine or alkali metal carbonates such as sodium carbonate or potassium carbonate, which are preferably employed in equimolar amounts or up to a four-fold excess based on the ester. By preference, triethylamine or alkali metal carbonates are employed, preferably in twice the equimolar ratio based on the ester.
- Suitable cyano compounds are inorganic cyanides, such as sodium cyanide, potassium cyanide and organic cyano compounds such as acetone cyanohydrin or trimethylsilyl cyanide. They are employed in an amount of 1 to 50 mol percent based on the ester. Preferably, acetone cyanohydrin or trimethylsilyl cyanide are employed, for example in an amount of 5 to 25, preferably 5 to 15, in particular 10, mol percent based on the ester.
- Work-up can be carried out in a conventional manner. For example, the reaction mixture is acidified with dilute mineral acid, such as 5% strength hydrochloric acid or sulfuric acid, and extracted With an organic solvent, for example methylene chloride or ethyl acetate. The organic extract can be extracted with 5-10% strength alkali metal carbonate solution, for example sodium carbonate or potassium carbonate solution. The aqueous phase is acidified, and the precipitate which forms is filtered off with suction and/or extracted with methylene chloride or ethyl acetate, dried and concentrated.
- (Examples of the synthesis of hydroxypyrazole esters and of the rearrangement of the esters are given for example in EP-A 282 944 and U.S. Pat. No. 4,643,757).
- Process B:
-
- L2 is a nucleophilically displaceable leaving group such as halogen, e.g. bromine or chlorine, or hetaryl, e.g. imidazolyl, pyridyl, sulfonate.
- The compounds of the formula V can be employed directly, such as, for example, in the case of the sulfonyl halides or sulfonic anhydrides, or generated in situ, for example activated sulfonic acids (by means of sulfonic acid and dicyclohexylcarbonyldiimide, carbonyldiimidazole and the like).
- As a rule, the starting compounds are employed in an equimolar ratio. However, it may also be advantageous to employ one or the other component in excess.
- If appropriate, it may be advantageous to carry out the reaction in the presence of a base. The reactants and the auxiliary base are expediently employed in equimolar amounts. Under certain circumstances, an excess of the auxiliary base, for example 1.5 to 3 mol equivalents based on II, may be advantageous.
- Suitable auxiliary bases are tertiary alkylamines such as triethylamine or pyridine, alkali metal carbonates, e.g. sodium carbonate or potassium carbonate, and alkali metal hydrides, e.g. sodium hydride. Triethylamine and pyridine are preferably used.
- Examples of suitable solvents are chlorinated hydrocarbons such as methylene chloride or 1,2-dichloroethane, aromatic hydrocarbons, e.g. toluene, xylene or chlorobenzene, ethers such as diethyl ether, methyl tert-butyl ether, tetrahydrofuran or dioxane, polar aprotic solvents such as acetonitrile, dimethylformamide or dimethyl sulfoxide, or esters such as ethyl acetate, or mixtures of these.
- As a rule, the reaction temperature is in the range of from 0° C. up to the boiling point of the reaction mixture.
- Work-up can be carried out in a conventional manner to give the product.
- Process C:
-
- Examples of suitable halogating agents are phosgene, diphosgene, triphosgene, thionyl chloride, oxalyl chloride, phosphorus oxychloride, phosphorus pentachloride, mesyl chloride, chloromethylene-N,N-dimethylammonium chloride, oxalyl bromide, phosphorus oxybromide and the like.
- As a rule, the starting compounds are employed in an equimolar ratio. It may also be advantageous to employ one or the other component in excess.
- Examples of suitable solvents are chlorinated hydrcarbons such as methylene chloride or 1,2-dichloroethane, aromatic hydrocarbons, e.g. toluene, xylene or chlorobenzene, polar aprotic solvents such as acetonitrile, dimethylformamide or dimethyl sulfoxide, or mixtures of these. It is also possible to carry out the reaction without solvent.
- As a rule, the reaction temperature is in the range of from 0° C. up to the boiling point of the reaction mixture.
- Work-up can be carried out in a conventional manner to give the product.
- Process D:
-
- As a rule, the starting compounds are employed in an equimolar ratio. However, it may also be advantageous to employ one or the other component in excess.
- If appropriate, it may also be advantageous to carry out the reaction in the presence of a base. The reactants and the base are expediently employed in equimolar quantities. An excess of base, for example 1.5 to 3 mol equivalents based on I where R8=Hal, may be advantageous under certain circumstances.
- Bases which are suitable are tertiary alkylamines such as triethylamine, aromatic amines such as pyridine, alkali metal carbonates, e.g. sodium carbonate or potassium carbonate, alkali metal hydrogen carbonates such as sodium hydrogen carbonate or potassium hydrogen carbonate, alkali metal alkoxides such as sodium methoxide, sodium ethoxide or potassium tert-butoxide, or alkali metal hydrides such as e.g. sodium hydride. Sodium hydride or potassium tert-butoxide are preferably used.
- Examples of suitable solvents are chlorinated hydrocarbons such as methylene chloride or 1,2-dichloroethane, aromatic hydrocarbons, e.g. toluene, xylene or chlorobenzene, ethers such as diethyl ether, methyl tert-butyl ether, tetrahydrofuran or dioxane, polar aprotic solvents such as acetonitrile, dimethylformamide or dimethyl sulfoxide, or mixtures of these.
- As a rule, the reaction temperature is in the range of from 0° C. up to the boiling point of the reaction mixture.
- Work-up can be carried out in a conventional manner to give the product.
- Process E:
-
- Examples of suitable oxidants are m-chloroperbenzoic acid, peroxyacetic acid, trifluoroperoxyacetic acid, hydrogen peroxide, in the presence or absence of a catalyst such as tungstate.
- As a rule, the starting compounds are employed in an equimolar ratio. It may be advantageous to employ one or the other component in excess.
- Examples of suitable solvents are chlorinated hydrocarbons such as methylene chloride or 1,2-dichloroethane, aromatic hydrocarbons, e.g. toluene, xylene or chlorobenzene, ethers such as diethyl ether, methyl tert-butyl ether, tetrahydrofuran or dioxane, polar aprotic solvents such as acetonitrile or dimethylformamide, or esters such as ethyl acetate, or mixtures of these.
- As a rule, the reaction temperature is in the range of from 0° C. up to the boiling point of the reaction mixture.
- Work-up can be carried out in a conventional manner to give the product.
- The cyclohexenones of the formula II (where R12═OH) which are used as starting materials are known or can be prepared by conventional processes (for example EP-A 240 001 and J. Prakt. Chem. 315, 383 (1973)).
-
- the variables having the following meanings:
- R1, R2 are hydrogen, nitro, halogen, cyano, C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C6-haloalkoxy, C1-C6-alkylthio, C1-C6-haloalkylthio, C1-C6-alkylsulfinyl, C1-C6-haloalkylsulfinyl, C1-C6-alkylsulfonyl or C1-C6-haloalkylsulfonyl;
- R3 is hydrogen, halogen or C1-C6-alkyl;
- R4 is hydrogen or C1-C4-alkyl;
- R5, R6 are hydrogen, halogen, cyano, nitro, C1-C4-alkyl, C1-C4-alkoxy-C1-C4-alkyl, di(C1-C4-alkoxy)-C1-C4-alkyl, di(C1-C4-alkyl)amino-C1-C4-alkyl, di(C1-C4-alkyl)aminoimino-C1-C4-alkyl, hydroxyimino-C1-C4-alkyl, C1-C6-alkoxyimino-C1-C4-alkyl, C1-C4-alkoxycarbonyl-C1-C4-alkyl, C1-C4-alkylthio-C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-cyanoalkyl, C3-C8-cycloalkyl, C1-C4-alkoxy, C1-C4-alkoxy-C2-C4-alkoxy, C1-C4-haloalkoxy, C1-C4-alkylthio, C1-C4-haloalkylthio, di(C1-C4-alkyl)amino, COR8, phenyl or benzyl, it being possible for the two last-mentioned substituents to be partially or fully halogenated and/or to have attached to them one to three of the following groups:
- nitro, cyano, C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy or C1-C4-haloalkoxy;
- or
- R5 and R6 together form a C2-C6-alkanediyl chain which can be mono-to tetrasubstituted by C1-C4-alkyl and/or can be interrupted by oxygen or an unsubstituted or C1-C4-alkyl-substituted nitrogen;
- R7 is halogen, cyano, hydroxyl, C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C6-haloalkoxy, C1-C6-alkylthio, C1-C6-haloalkylthio, C1-C6-alkylsulfinyl, C1-C6-haloalkylsulfinyl, C1-C6-alkylsulfonyl, C1-C6-haloalkylsulfonyl, amino, C1-C6-alkylamino, di(C1-C6-alkyl)amino, di(C1-C4-alkoxy)methyl, hydroxyimino-C1-C4-alkyl, C1-C6-alkoxyimino-C1-C4-alkyl or COR8;
- R8 is hydrogen, C1-C4-alkyl, C1-C4-haloalkyl, hydroxyl, C1-C4-alkoxy, C1-C4-alkoxy-C2-C4-alkoxy, C1-C4-haloalkoxy, C3-C6-alkenyloxy, C3-C6-alkynyloxy or NR9R10;
- R9 is hydrogen or C1-C4-alkyl;
- R10 is C1-C4-alkyl;
- R15 is hydroxyl or a radical which can be eliminated by hydrolysis.
- Examples of radicals which can be eliminated by hydrolysis are alkoxy, phenoxy, alkylthio or phenylthio radicals which can be unsubstituted or substituted, or halides, hetaryl radicals which are bound via nitrogen, or amino, imino radicals which can be unsubstituted or substituted, and the like.
-
- where the variables R1 to R7 have the meanings stated under formula III and
- L1 is halogen, in particular chlorine or bromine.
-
- where the variables R1 to R7 have the meanings stated under formula III.
-
- where the variables R1 to R7 have the meanings stated under formula III and
- L3 is C1-C6-alkoxy.
- The especially preferred embodiments of the 3-(4,5-dihydroisoxazol-5-yl)carboxylic acid derivatives of the formula III with regard to the variables R1 to R7 correspond to those of the 3-(4,5-dihydroisoxazol-5-yl)cyclohexenones of the formula I.
- The 3-(4,5-dihydroisoxazol-5-yl)carbonyl halides of the formula IIIα′ (where L1′=Cl, Br,) can be prepared in a conventional manner by reacting the 3-(4,5-dihydroisoxazol-5-yl)carboxylic acids of the formula IIIβ with halogenating reagents such as thionyl chloride, thionyl bromide, phosgene, diphosgene, triphosgene, oxalyl chloride or oxalyl bromide.
-
-
- Furthermore, it is possible to convert compounds of the formula VI in a Rosenmund-von Braun reaction into the corresponding nitriles of the formula VII (cf., for example, Org. Synth. Vol. III, 212 (1955)) and to convert the latter into the compounds of the formula IIIβ by subsequently hydrolyzing them.
-
- the variables having the following meanings:
- R1, R2 are hydrogen, nitro, halogen, cyano, C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C6-haloalkoxy, C1-C6-alkylthio, C1-C6-haloalkylthio, C1-C6-alkylsulfinyl, C1-C6-haloalkylsulfinyl, C1-C6-alkylsulfonyl or C1-C6-haloalkylsulfonyl;
- R3 is hydrogen, halogen or C1-C6-alkyl;
- R4 is hydrogen or C1-C4-alkyl;
- R5, R6 are hydrogen, halogen, cyano, nitro, C1-C4-alkyl, C1-C4-alkoxy-C1-C4-alkyl, di(C1-C4-alkoxy)-C1-C4-alkyl, di(C1-C4-alkyl)amino-C1-C4-alkyl, di(C1-C4-alkyl)aminoimino-C1-C4-alkyl, hydroxyimino-C1-C4-alkyl, C1-C6-alkoxyimino-C1-C4-alkyl, C1-C4-alkoxycarbonyl-C1-C4-alkyl, C1-C4-alkylthio-C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-cyanoalkyl, C3-C8-cycloalkyl, C1-C4-alkoxy, C1-C4-alkoxy-C2-C4-alkoxy, C1-C4-haloalkoxy, C1-C4-alkylthio, C1-C4-haloalkylthio, di(C1-C4-alkyl)amino, COR8, phenyl or benzyl, it being possible for the two last-mentioned substituents to be partially or fully halogenated and/or to have attached to them one to three of the following groups:
- nitro, cyano, C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy or C1-C4-haloalkoxy;
- or
- R5 and R6 together form a C2-C6-alkanediyl chain which can be mono-to tetrasubstituted by C1-C4-alkyl and/or can be interrupted by oxygen or an unsubstituted or C1-C4-alkyl-substituted nitrogen;
- R7 is halogen, cyano, hydroxyl, C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C6-haloalkoxy, C1-C6-alkylthio, C1-C6-haloalkylthio, C1-C6-alkylsulfinyl, C1-C6-haloalkylsulfinyl, C1-C6-alkylsulfonyl, C1-C6-haloalkylsulfonyl, amino, C1-C6-alkylamino, di(C1-C6-alkyl)amino, di(C1-C4-alkoxy)methyl, hydroxyimino-C1-C4-alkyl, C1-C6-alkoxyimino-C1-C4-alkyl or COR8;
- R8 is hydrogen, C1-C4-alkyl, C1-C4-haloalkyl, hydroxyl, C1-C4-alkoxy, C1-C4-alkoxy-C2-C4-alkoxy, C1-C4-haloalkoxy, C3-C6-alkenyloxy, C3-C6-alkynyloxy or NR9R10;
- R9 is hydrogen or C1-C4-alkyl;
- R10 is C1-C4-alkyl; and
- L4 is halogen.
- The particular embodiments of the compounds of the formula VI or VII with regard to the variables R1 to R7 correspond to those of the 3-(4,5-dihydroisoxazol-5-yl)benzoylcyclohexenones of the formula I.
-
- The nitrile oxides are generated in situ in a conventional manner. The starting materials used for this purpose are, for example, aldoximes (cf., for example, Houben-Weyl X5, p. 858 et seq.) or nitroalkanes (cf., for example, Houben-Weyl E5/2, p. 1594 et seq.). The synthesis of the compounds of the formula VIII or IX is known (cf., for example, WO 98/50337 and WO 98/50366) or is carried out in analogy to processes known from the literature.
- 2-[2-Methyl-3-(3-methyl-4,5-dihydroisoxazol-5-yl)-4-methylsulfonylbenzoyl]-1-hydroxycyclohex-1-en-3-one
- A solution of 2.3 g (7.7 mmol) of 2-methyl-3-(3-methyl-4,5-dihydroisoxazol-5-yl)-4-methylsulfonylbenzoyl chloride in 50 ml of acetonitrile was added dropwise at 0-5° C. to a solution of 0.86 g (7.7 mmol) of 1-hydroxycyclohex-1-en-3-one and 2.13 ml (15.4 mmol) of triethylamine in 50 ml of acetonitrile. After the mixture had been stirred for three hours at room temperature, a further 0.64 ml (4.6 mmol) of triethylamine and 0.16 g (15 mmol) of trimethylsilyl cyanide were added and the mixture was stirred for twelve hours at room temperature. The reaction mixture was then stirred into 800 ml of water and washed with methylene chloride. The aqueous phase was then brought to pH 4 using 10% strength hydrochloric acid and extracted with methylene chloride. After the organic phase had been dried, the solvent was removed and the residue was taken up in diethyl ether and digested. The resulting residue was filtered off with suction. This gave 1.3 g (3.3 mmol; 43% of theory) of the title compounds.
- M.p. 135-140° C.
- Tables 2 and 3 show not only the above compound, but also further derivatives of the formula I which were, or can be, prepared analogously.
TABLE 2 I where R3, R4 and R6 = H Physical data No. R1 R2 R5 R7 R13 R14 R15 R16 R17 R18 m.p. [° C.] 2.1 Cl Cl H C(CH3)3 H H H H H H 65-75 2.2 Cl SO2CH3 H CO2CH2CH3 H H H H H H 154-158 2.3 Cl Cl H CO2CH2CH3 H H H H H H 77-81 2.4 Cl Cl H CH3 H H H H H H 84-94 2.5 CH3 SO2CH3 H CH3 H H H H H H 135-140 2.6 Cl SO2CH3 H CH3 H H H H H H 115-125 2.7 Cl Cl H CH3 CH3 CH3 ═O CH3 CH3 82-85 2.8 Cl SO2CH3 H CH3 H H CH3 H H H 190-193 2.9 Cl SO2CH3 H CH3 H H CH3 CH3 H H 114-124 2.10 Cl SO2CH3 H CH3 H H H H CH3 CH3 164-168 2.11 Cl SO2CH3 H CH3 CH3 CH3 ═O CH3 CH3 103-105 2.12 CH3 SO2CH3 H CH3 CH3 CH3 ═O CH3 CH3 180-200 2.13 CH3 SO2CH3 H CH3 H H H H CH3 CH3 190-195 2.14 Cl Cl H CH3 H H CH3 H H H 81-84 2.15 Cl Cl H CH3 H H CH3 CH3 H H 63-65 2.16 Cl Cl H CH3 H H H H CH3 CH3 74-84 2.17 Cl Cl H CH3 CH3 H H H CH3 H 80-85 2.18 Cl Cl H CH3 CH3 H H H CH3 CH3 80-85 2.19 OCH3 SO2CH3 H CH3 H H CH3 CH3 H H 95-102 2.20 OCH3 SO2CH3 H CH3 H H H H H H 175-185 2.21 CH3 SO2CH3 H CH3 H H CH3 H H H 134-138 2.22 CH3 SO2CH3 H CH3 H H CH3 CH3 H H 183-186 2.23 OCH3 SO2CH3 H CH3 CH3 CH3 ═O CH3 CH3 165-168 2.24 Cl Cl H COCH3 H H H H H H 73-78 -
- The syntheses of some starting materials are shown hereinbelow:
- Methyl 2,4-dichloro-3-(3-t-butyl-4,5-dihydroisoxazol-5-yl)benzoate
- 17 ml of a 12% strength aqueous sodium hypochlorite solution were added dropwise at room temperature into a vigorously stirred solution of 2.6 g (10 mmol) of methyl 2,4-dichloro-3-ethenylbenzoate and 1 g (10 mmol) of 2,2-dimethylpropional-doxime in 100 ml of dichloromethane. After the mixture had been stirred for in each case 2 hours, two further portions of 0.5 g (5 mmol) of the oxime and 9 ml of the hypochlorite solution were added. Stirring was continued for 12 hours at room temperature, and the reaction mixture was then stirred into 350 ml of water. After extraction with dichloromethane, drying and removal of the solvent, the residue was chromatographed.
- Yield: 1.5 g (45% of theory) of yellow resin
- Methyl 2-chloro-3-(3-ethoxycarbonyl-4,5-dihydroisoxazol-5-yl)-4-methylsulfonylbenzoate.
- 6.4 ml (46 mmol) of triethylamine were added slowly dropwise at room temperature to a solution of 8.5 g (31 mmol) of methyl 2-chloro-3-ethenyl-4-methylsulfonylbenzoate and 7.2 g (46 mmol) of ethyl 2-chloro-2-hydroxyiminoacetate in 200 ml of dichloromethane. After the mixture had been stirred for in each case 2 hours, 3 further portions of in each case 4.8 g (31 mmol) of ethyl 2-chloro-2-hydroxyiminoacetate and then 4.3 ml (31 mmol) of triethylamine were added. Stirring was continued for 12 hours at room temperature, and the reaction mixture was then stirred into 600 ml of water. After extraction with dichloromethane, drying and removal of the solvent, the residue was chromatographed.
- Yield: 5.7 g (47% of theory) of clear resin.
- 2-Chloro-3-(3-methyl-4,5-dihydroisoxazol-5-yl)-4-methylsulfonylbenzoic acid
- a) Methyl 2-chloro-3-(3-methyl-4,5-dihydroisoxazol-5-yl)-4-methylsulfonylbenzoate.
- One spatula-tip full of 4-dimethylaminopyridine was added to a solution of 40 g (145 mmol) of methyl 2-chloro-3-ethenyl-4-methylsulfonylbenzoate and 50 g (220 mmol) of di-t-butyl dicarbonate in 300 ml of acetonitrile, and 50 g (640 mmol) of nitroethane were then added dropwise. After the mixture had been stirred for 12 hours at room temperature, a further 32.8 g (145 mmol) of di-t-butyl dicarbonate and 22.9 g (290 mmol) of nitroethane were added. After a further 12 hours, the solvent was distilled off and the residue was digested with ethyl acetate. Following filtration with suction, 32.1 g of the desired compound remained. A further 6.3 g were obtained from the mother liquor after removal of the solvent followed by chromatography.
- Yield: 39.4 g (82% of theory)
- M.p.: 175° C.
- b) Methyl 2-chloro-3-(3-methyl-4,5-dihydroisoxazol-5-yl)-4-methylsulfonylbenzoic acid
- 69.4 g (174 mmol) of 10% strength sodium hydroxide solution were added to a solution of 38.4 g (116 mmol) of methyl 2-chloro-3-(3-methyl-4,5-dihydroisoxazol-5-yl)-4-methylsulfonylbenzoate in 400 ml of methanol and 400 ml of tetrahydrofuran. The mixture was stirred for 12 hours at room temperature, the solvent volume was reduced to half, and the mixture was poured into 1 l of water. The pH was brought to 1 using 10% strength hydrochloric acid, and the precipitate which formed was filtered off with suction.
- Yield: 35.2 g (96% of theory)
- M.p.: >220° C.
- 2-Methyl-3-(3-methyl-4,5-dihydroisoxazol-5-yl)-4-methylsulfonylbenzoic acid
- a) 2-Methyl-3-(3-methyl-4,5-dihydroisoxazol-5-yl)methylsulfonylbenzoic acid
- One spatula-tip full of 4-dimethylaminopyridine was added to a solution of 13.6 g (50 mmol) of 2-methyl-3-ethenyl-4-methylsulfonylbromobenzene and 16.7 g (74 mmol) of di-t-butyl dicarbonate in 100 ml of acetonitrile, and 17.9 g (229 mmol) of nitroethane were then slowly added dropwise. After the mixture had been stirred for 6 hours at room temperature, a further 11.1 g (50 mmol) of di-t-butyl dicarbonate and 7.8 g (100 mmol) of nitroethane were added and the mixture was stirred for 12 hours at room temperature.
- After the solvent had been removed, the residue was chromatographed.
- Yield: 6.4 g (38% of theory)
- b) 2-Methyl-3-(3-methyl-4,5-dihydroisoxazol-5-yl)-4-methylsulfonylbenzoic acid
- 6.4 g (19 mmol) of 2-methyl-3-(3-methyl-4,5-dihydroisoxazol-5-yl)-4-methylsulfonylbromobenzene were dissolved in 65 ml of toluene and 30 ml of water and treated with 240 mg (1 mmol) of palladium acetate, 1.1 g (4 mmol) of tricyclohexylphosphane, 810 mg (19 mmol) of lithium chloride and 5.4 ml (38 mmol) of triethylamine. The resulting solution was then stirred in an autoclave for 36 hours at 140° C. under a carbon monoxide pressure of 20 bar. After cooling the autoclave and releasing the pressure, insoluble constituents were removed by filtration, and the phases were separated. The organic phase was subsequently extracted twice with water containing a little triethylamine. The combined aqueous phases were then brought to pH 1 using 10% hydrochloric acid, and the precipitate which formed was filtered off.
- Yield: 2.5 g (44% of theory)
- M.p.: 199-205° C.
- Table 4 which follows lists not only the above-described compounds, but also further 3-(4,5-dihydroisoxazol-5-yl)carboxylic acid derivatives of the formula III which are prepared, or can be prepared, analogously.
TABLE 4 I where R4 and R6 = H Physical data No. R1 R2 R3 R5 R7 R15 [° C.] 4.1 Cl Cl H H CH3 OCH3 Resin 4.2 Cl Cl H H CH3 OH Resin 4.3 Cl Cl H H C(CH3)3 OCH3 Resin 4.4 Cl Cl H H C(CH3)3 OH 4.5 Cl SO2CH3 H H C(CH3)3 OCH3 54-55 4.6 Cl SO2CH3 H H C(CH3)3 OH 97-100 4.7 Cl Cl H H COOEt OCH3 Oil 4.8 Cl Cl H H COOEt OH 4.9 Cl SO2CH3 H H COOEt OCH3 Resin 4.10 Cl SO2CH3 H H COOEt OH 82-90 4.11 Cl Cl H H COOH OH 182-183 4.12 Cl Cl H H CF3 OCH3 Oil 4.13 Cl Cl H H CF3 OH 4.14 Cl SO2CH3 H H CH3 OCH3 175 4.15 Cl SO2CH3 H H CH3 OH >220 4.16 CH3 SO2CH3 H H CH3 OCH3 120-121 4.17 CH3 SO2CH3 H H CH3 OH 199-205 4.18 Cl SO2CH3 H H CH(OC2H5)2 OCH3 Resin 4.19 Cl SO2CH3 H H CH(OC2H5)2 OH 4.20 Cl SO2CH3 H H CHO OCH3 4.21 Cl SO2CH3 H H CHO OH 4.22 Cl Cl H CH3 C(CH3)3 OCH3 4.23 Cl Cl H CH3 C(CH3)3 OH 4.24 Cl Cl H H COCH3 OCH3 4.25 Cl Cl H H COCH3 OH 4.26 Cl Cl H H Cl OCH3 4.27 Cl Cl H H Cl OH - The 3-(4,5-dihydroisoxazol-5-yl)benzoylcyclohexenones of the formula I and their agriculturally useful salts, both in the form of the isomer mixtures and in the form of the pure isomers, are suitable as herbicides. The herbicidal compositions comprising compounds of the formula I effect very good control of vegetation on non-crop areas, especially at high rates of application. In crops such as wheat, rice, maize, soya and cotton, they act against broad-leaved weeds and grass weeds without damaging the crop plants significantly. This effect is observed especially at low application rates.
- Depending on the application method in question, the compounds of the formula I or herbicidal compositions comprising them can additionally be employed in a further number of crop plants for eliminating undesired plants. Examples of suitable crop plants are:
-
- Moreover, the compunds of the formula I can also be used in crops which tolerate the action of herbicides due to breeding, including recombinant methods.
- The compounds of the formula I, or the herbicidal compositions comprising them, can be employed, for example, in the form of directly sprayable aqueous solutions, powders, suspensions, also highly-concentrated aqueous, oily or other suspensions or dispersions, emulsions, oil dispersions, pastes, dusts, materials for spreading or granules, by means of spraying, atomizing, dusting, spreading or pouring, or as a seed treatment or by mixing with the seed. The use forms depend on the intended purposes; in any case, they should guarantee the finest possible distribution of the active ingredients according to the invention.
- The herbicidal compositions comprise a herbicidally active amount of at least one compound of the formula I or of an agriculturally useful salt of I and adjuvants conventionally used for the formulation of crop protection products.
- Suitable inert auxiliaries are essentially: mineral oil fractions of medium to high boiling point such as kerosene and diesel oil, furthermore coal tar oils and oils of vegetable or animal origin, aliphatic, cyclic and aromatic hydrocarbons, e.g. paraffins, tetrahydronaphthalene, alkylated naphthalenes and their derivatives, alkylated benzenes and their derivatives, alcohols such as methanol, ethanol, propanol, butanol and cyclohexanol, ketones such as cyclohexanone, strongly polar solvents, e.g. amines such as N-methylpyrrolidone, and water.
- Aqueous use forms can be prepared from emulsion concentrates, suspensions, pastes, wettable powders or water-dispersable granules by adding water. To prepare emulsions, pastes or oil dispersions, the 3-(4,5-dihydroisoxazol-5-yl)benzoylcyclohexenones, as such or dissolved in an oil or solvent, can be homogenized in water by means of wetters, tackifiers, dispersants or emulsifiers. However, it is also possible to prepare concentrates composed of active substance, wetter, tackifier, dispersant or emulsifier and, if appropriate, solvent or oil which are suitable for dilution with water.
- Suitable surfactants (adjuvants) are the alkali metal salts, alkaline earth metal salts and ammonium salts of aromatic sulfonic acids, e.g. ligno-, phenol-, naphthalene-and dibutylnaphthalenesulfonic acid, and of fatty acids, of alkyl- and alkylarylsulfonates, of alkyl sulfates, lauryl ether sulfates and fatty alcohol sulfates, and salts of sulfated hexa-, hepta- and octadecanols, and of fatty alcohol glycol ether, condensates of sulfonated naphthalene and its derivatives with formaldehyde, condensates of naphthalene, or of the naphthalenesulfonic acids, with phenol and formaldehyde, polyoxyethylene octylphenol ether, ethoxylated isooctyl-, octyl-or nonylphenol, alkylphenyl and tributylphenyl polyglycol ether, alkylaryl polyether alcohols, isotridecyl alcohol, fatty alcohol/ethylene oxide condensates, ethoxylated castor oil, polyoxyethylene alkyl ethers or polyoxypropylene alkyl ethers, lauryl alcohol polyglycol ether acetate, sorbitol esters, lignin-sulfite waste liquors or methylcellulose.
- Powders, materials for spreading and dusts can be prepared by mixing or concomitantly grinding the active substances with a solid carrier.
- Granules, for example coated granules, impregnated granules and homogeneous granules, can be prepared by binding the active ingredients to solid carriers. Solid carriers are mineral earths such as silicas, silica gels, silicates, talc, kaolin, limestone, lime, chalk, bole, loess, clay, dolomite, diatomaceous earth, calcium sulfate, magnesium sulfate, magnesium oxide, ground synthetic materials, fertilizers such as ammonium sulfate, ammonium phosphate, ammonium nitrate, ureas and products of vegetable origin such as cereal meal, tree bark meal, wood meal and nutshell meal, cellulose powders or other solid carriers.
- The concentrations of the compounds of the formula I in the ready-to-use products can be varied within wide ranges. In general, the formulations comprise approximately from 0.001 to 98% by weight, preferably 0.01 to 95% by weight, of at least one active ingredient. The active ingredients are employed in a purity of from 90% to 100%, preferably 95% to 100% (according to NMR spectrum).
- The formulation examples below illustrate the preparation of such products:
- I. 20 parts by weight of the compound No. 2.5 are dissolved in a mixture composed of 80 parts by weight of alkylated benzene, 10 parts by weight of the adduct of 8 to 10 mol of ethylene oxide and 1 mol of oleic acid N-monoethanolamide, 5 parts by weight of calcium dodecylbenzenesulfonate and 5 parts by weight of the adduct of 40 mol of ethylene oxide and 1 mol of castor oil. Pouring the solution into 100000 parts by weight of water and finely distributing it therein gives an aqueous dispersion which comprises 0.02% by weight of the active ingredient.
- II. 20 parts by weight of the compound No. 2.9 are dissolved in a mixture composed of 40 parts by weight of cyclohexanone, 30 parts by weight of isobutanol, 20 parts by weight of the adduct of 7 mol of ethylene oxide and 1 mol of isooctylphenol and 10 parts by weight of the adduct of 40 mol of ethylene oxide and 1 mol of castor oil. Pouring the solution into 100000 parts by weight of water and finely distributing it therein gives an aqueous dispersion which comprises 0.02% by weight of the active ingredient.
- III. 20 parts by weight of the active ingredient No. 2.5 are dissolved in a mixture composed of 25 parts by weight of cyclohexanone, 65 parts by weight of a mineral oil fraction of boiling point 210 to 280° C. and 10 parts by weight of the adduct of 40 mol of ethylene oxide and 1 mol of castor oil. Pouring the solution into 100000 parts by weight of water and finely distributing it therein gives an aqueous dispersion which comprises 0.02% by weight of the active ingredient.
- IV. 20 parts by weight of the active ingredient No. 2.9 are mixed thoroughly with 3 parts by weight of sodium diisobutylnaphthalenesulfonate, 17 parts by weight of the sodium salt of a lignosulfonic acid from a sulfite waste liquor and 60 parts by weight of pulverulent silica gel, and the mixture is ground in a hammer mill. Finely distributing the mixture in 20000 parts by weight of water gives a spray mixture which comprises 0.1% by weight of the active ingredient.
- V. 3 parts by weight of the active ingredient No. 2.5 are mixed with 97 parts by weight of finely divided kaolin. This gives a dust which comprises 3% by weight of the active ingredient.
- VI. 20 parts by weight of the active ingredient No. 2.9 are mixed intimately with 2 parts by weight of calcium dodecylbenzenesulfonate, 8 parts by weight of fatty alcohol polyglycol ether, 2 parts by weight of the sodium salt of a phenol/urea/formaldehyde condensate and 68 parts by weight of a paraffinic mineral oil. This gives a stable oily dispersion.
- VII. 1 part by weight of the active ingredient No. 2.5 is dissolved in a mixture composed of 70 parts by weight of cyclohexanone, 20 parts by weight of ethoxylated isooctylphenol and 10 parts by weight of ethoxylated castor oil. This gives a stable emulsion concentrate.
- VIII,. 1 part by weight of the active ingredient No. 2.4 is dissolved in a mixture composed of 80 parts by weight of cyclohexanone and 20 parts by weight of Wettol® EM 31 (=nonionic emulsifier based on ethoxylated castor oil). This gives a stable emulsion concentrate.
- The compounds of the formula I or the herbicidal compositions can be applied pre-emergence, post-emergence or together with the seed of a crop plant. It is also possible to apply the compounds of the formula I or the herbicidal compositions by sowing the seed, of a crop plant, which has been pretreated with the herbicidal compositions or active ingredients. If the active ingredients are less well tolerated by certain crop plants, application techniques may be used in which the herbicidal compositions are sprayed with the aid of the spraying equipment in such a way that they come into very little contact, if any, with the leaves of the sensitive crop plants, while the active ingredients reach the leaves of undesired plants growing underneath, or the naked soil surface (post-directed, lay-by).
- Depending on the intended aim of the control measures, the season, the target plants and the growth stage, the application rates of compound of the formula I are from 0.001 to 3.0, preferably from 0.01 to 1.0, kg of active substance (a.s.) per ha.
- To widen the spectrum of action and to achieve synergistic effects, the 3-(4,5-dihydroisoxazol-5-yl)benzoylcyclohexenones of the formula I can be mixed with a large number of representatives of other groups of active ingredients which act as herbicides or as growth regulators and applied together with these. Suitable components in mixtures are, for example, 1,2,4-thiadiazoles, 1,3,4-thiadiazoles, amides, aminophosphoric acid and its derivatives, aminotriazoles, anilides, aryloxy-/heteroaryloxyalkanoic acids and their derivatives, benzoic acid and its derivatives, benzothiadiazinones, 2-(hetaroyl/aroyl)-1,3-cyclohexanediones, heteroaryl aryl ketones, benzylisoxazolidinones, meta-CF3-phenyl derivatives, carbamates, quinolinecarboxylic acid and its derivatives, chloroacetanilides, cyclohexenone oxime ether derivatives, diazines, dichloropropionic acid and its derivatives, dihydrobenzofurans, dihydrofuran-3-ones, dinitroanilines, dinitrophenols, diphenyl ethers, dipyridyls, halocarboxylic acids and their derivatives, ureas, 3-phenyluracils, imidazoles, imidazolinones, N-phenyl-3,4,5,6-tetrahydrophthalimides, oxadiazoles, oxiranes, phenols, aryloxy-and heteroaryloxyphenoxypropionic esters, phenylacetic acid and its derivatives, phenylpropionic acid and its derivatives, pyrazoles, phenylpyrazoles, pyridazines, pyridinecarboxylic acid and its derivatives, pyrimidyl ethers, sulfonamides, sulfonylureas, triazines, triazinones, triazolinones, triazolecarboxamides and uracils.
- Moreover, it may be advantageous to apply the compounds of the formula I, alone or in combination with other herbicides, or in the form of a mixture with other crop protection agents, for example with agents for controlling pests or phytopathogenic fungi or bacteria. Also of interest is the miscibility with mineral salt solutions, which are employed for treating nutritional and trace element deficiencies. Nonphytotoxic oils and oil concentrates can also be added.
- Use Examples
- The herbicidal action of the 3-(4,5-dihydroisoxazol-5-yl)benzoylcyclohexenones of the formula I was demonstrated by the following greenhouse experiments:
- The culture containers used were plastic flower pots containing loamy sand with approximately 3.0% of humus as substrate. The seeds of the test plant were sown separately for each species.
- For the pre-emergence treatment, the active ingredients, which were suspended or emulsified in water, were applied directly after sowing by means of finely distributing nozzles. The containers were irrigated gently to promote germination and growth and subsequently covered with transparent plastic hoods until the plants had rooted. This cover caused uniform germination of the test plants unless this was adversely affected by the active ingredients.
- For the post-emergence treatment, the test plants were first grown to a plant height of from 3 to 15 cm, depending on the plant habit, and only then treated with the active ingredients which had been suspended or emulsified in water. To this end, the test plants were either sown directly and grown in the same containers, or they were first grown separately as seedlings and transplanted into the test containers a few days prior to the treatment. The rate of application for the post-emergence the treatment was 125 or 62.5 g of a.s. (active substance) per ha.
- Depending on the species, the plants were kept at temperatures of from 10 to 25° C. or from 20 to 35° C. The test period extended over 2 to 4 weeks. During this time, the plants were tended, and their response to the individual treatments was evaluated.
- Evaluation was carried out using a scale of from 0 to 100. 100 means no emergence of the plants, or complete destruction of at least the aerial parts, and 0 means no damage or normal course of growth.
- The plants used in the greenhouse experiments belonged to the following species:
Scientific name Common name Amaranthus retroflexus redroot pigweed Chenopodium album lambsquarters (goosefoot) Digitaria sanguinalis hairy fingergrass Panicum dichotomiflorum fall panicum Polygonum persicaria ladysthumb Solanum nigrum black nightshade Stellaria media common chickweed Matricaria false chamomile Brachiaria platyphylla broadleaf signal grass Lamium amplexicaule henbit - When rates of application of 125 or 62.5 g/ha a.s. were employed, the compound 2.4 was very effective against Brachiaria platyphylla, lambsquarters, Lamium amplexicaule, chamomile and common chickweed. Equally, the compound 2.9 controlled redroot pigweed, lambsquarters, hairy fingergrass, ladysthumb and fall panicum very efficiently under analogous conditions. Used pre-emergence at application rates of 125 or 62.5 g/ha, the compound 2.5 controls redroot pigweed, hairy fingergrass, lambsquarters and black nightshade highly efficiently.
Claims (17)
1. A 3-(4,5-dihydroisoxazol-5-yl)benzoylcyclohexenone of the formula I
in which the variables have the following meanings:
R1, R2 are hydrogen, nitro, halogen, cyano, C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C6-haloalkoxy, C1-C6-alkylthio, C1-C6-haloalkylthio, C1-C6-alkylsulfinyl, C1-C6-haloalkylsulfinyl, C1-C6-alkylsulfonyl or C1-C6-haloalkylsulfonyl;
R3 is hydrogen, halogen or C1-C6-alkyl;
R4 is hydrogen or C1-C4-alkyl;
R5, R6 are hydrogen, halogen, cyano, nitro, C1-C4-alkyl, C1-C4-alkoxy-C1-C4-alkyl, di(C1-C4-alkoxy)-C1-C4-alkyl, di(C1-C4-alkyl)amino-C1-C4-alkyl, di(C1-C4-alkyl)aminoimino-C1-C4-alkyl, hydroxyimino-C1-C4-alkyl, C1-C6-alkoxyimino-C1-C4-alkyl, C1-C4-alkoxycarbonyl-C1-C4-alkyl, C1-C4-alkylthio-C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-cyanoalkyl, C3-C8-cycloalkyl, C1-C4-alkoxy, C1-C4-alkoxy-C2-C4-alkoxy, C1-C4-haloalkoxy, C1-C4-alkylthio, C1-C4-haloalkylthio, di(C1-C4-alkyl)amino, COR8, phenyl or benzyl, it being possible for the two last-mentioned substituents to be partially or fully halogenated and/or to have attached to them one to three of the following groups:
nitro, cyano, C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy or C1-C4-haloalkoxy;
or
R5 and R6 together form a C2-C6-alkanediyl chain which can be mono-to tetrasubstituted by C1-C4-alkyl and/or can be interrupted by oxygen or by unsubstituted or C1-C4-alkyl-substituted nitrogen;
R7 is halogen, cyano, hydroxyl, C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C6-haloalkoxy, C1-C6-alkylthio, C1-C6-haloalkylthio, C1-C6-alkylsulfinyl, C1-C6-haloalkylsulfinyl, C1-C6-alkylsulfonyl, C1-C6-haloalkylsulfonyl, amino, C1-C6-alkylamino, di(C1-C6-alkyl)amino, di(C1-C4-alkoxy)methyl, hydroxyimino-C1-C4-alkyl, C1-C6-alkoxyimino-C1-C4-alkyl or COR8;
R8 is hydrogen, C1-C4-alkyl, C1-C4-haloalkyl, hydroxyl, C1-C4-alkoxy, C1-C4-alkoxy-C2-C4-alkoxy, C1-C4-haloalkoxy, C3-C6-alkenyloxy, C3-C6-alkynyloxy or NR9R10;
R9 is hydrogen or C1-C4-alkyl;
R10 is C1-C4-alkyl;
R11 is a cyclohexenone of the formula II
which is linked in the 2-position and where
R12 is hydroxyl, mercapto, halogen, OR19, SR19, SOR20 or SO2R20;
R13, R17 are hydrogen, C1-C4-alkyl, C1-C4-alkylthio or C1-C4-alkoxycarbonyl;
R14, R16, R18 are hydrogen or C1-C4-alkyl;
R15 is hydrogen, hydroxyl, halogen, C1-C6-alkyl, C1-C6-haloalkyl, di(C1-C6-alkoxy)methyl, (C1-C6-alkoxy) (C1-C6-alkylthio)methyl, di(C1-C6-alkylthio)methyl, C1-C6-alkoxy, C1-C6-haloalkoxy, C1-C6-alkylthio, C1-C6-haloalkylthio, C1-C6-alkoxycarbonyl, C1-C6-haloalkoxycarbonyl, 1,3-dioxolan-2-yl, 1,3-dioxan-2-yl, 1,3-oxathiolan-2-yl, 1,3-oxathian-2-yl, 1,3-dithiolan-2-yl or 1,3-dithian-2-yl, it being possible for the six last-mentioned radicals to have attached to them one, two or three substituents selected from amongst C1-C4-alkyl;
or
13 and R14 or R17 and R18 together are C1-C5-alkanediyl which can have attached to it one, two or three substituents selected from amongst halogen, cyano, C1-C4-alkyl, C1-C4-haloalkyl or C1-C4-alkoxycarbonyl;
R14 and R15 or R15 and R18 together are a chemical bond or C1-C5-alkanediyl which can have attached to it one, two or three substituents selected from amongst halogen, cyano, C1-C4-alkyl, C1-C4-haloalkyl or C1-C4-alkoxycarbonyl;
or
R14 and R18 together are C1-C5-alkanediyl which can have attached to it one, two or three substituents selected from amongst halogen, cyano, C1-C4-alkyl, C1-C4-haloalkyl or C1-C4-alkoxycarbonyl;
or
R15 and R16 together are —O—(CH2)p—O—, —O—(CH2)p—S—, —S—(CH2)p—S—, —O—(CH2)q— or —S—(CH2)q—, each of which can have attached to it one, two or three substituents selected from amongst halogen, cyano, C1-C4-alkyl, C1-C4-haloalkyl or C1-C4-alkoxycarbonyl;
or
R15 and R16 together are an oxygen atom;
R19 is C1-C6-alkyl, C3-C6-alkenyl, C3-C6-haloalkenyl, C3-C6-alkynyl, C3-C6-cycloalkyl, C1-C20-alkylcarbonyl, C2-C20-alkenylcarbonyl, C2-C6-alkynylcarbonyl, C1-C6-alkoxycarbonyl, C3-C6-alkenyloxycarbonyl, C3-C6-alkynyloxycarbonyl, C1-C6-alkylthiocarbonyl, C1-C6-alkylaminocarbonyl, C3-C6-alkenylaminocarbonyl, C3-C6-alkynylaminocarbonyl, N,N-di(C1-C6-alkyl)aminocarbonyl, N—(C3-C6-alkenyl)-N—(C1-C6-alkyl)aminocarbonyl, N-(C3-C6-alkynyl)-N—(C1-C6-alkyl)aminocarbonyl, N-(C1-C6-alkoxy)-N—(C1-C6-alkyl)aminocarbonyl, N,N-di(C1-C6-alkyl)aminothiocarbonyl, C1-C6-alkoxyimino-C1-C6-alkyl, it being possible for the abovementioned alkyl, alkoxy and cycloalkyl radicals to be partially or fully halogenated and/or to have attached to them one, two or three substituents selected from amongst cyano, C1-C4-alkoxy, C1-C4-alkylthio, di(C1-C4-alkyl)amino, C1-C4-alkylcarbonyl, C1-C4-alkoxycarbonyl, C1-C4-alkoxy-C1-C4-alkoxycarbonyl, C1-C4-alkylaminocarbonyl, N,N-di(C1-C4-alkyl)aminocarbonyl or C3-C6-cycloalkyl;
phenyl, phenyl-C1-C6-alkyl, phenylcarbonyl-C1-C6-alkyl, phenylcarbonyl, phenoxycarbonyl, phenoxythiocarbonyl, heterocyclyl, heterocyclyl-C1-C6-alkyl, heterocyclylcarbonyl-C1-C6-alkyl, heterocyclylcarbonyl, heterocyclyloxycarbonyl, heterocyclyloxythiocarbonyl, it being possible for the phenyl or heterocyclyl radical of the abovementioned radicals to be partially or fully halogenated and/or to have attached to it one, two or three substituents selected from amongst nitro, cyano, C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy or C1-C4-haloalkoxy;
R20 is C1-C6-alkyl, C3-C6-alkenyl, C3-C6-haloalkenyl, C3-C6-alkynyl or C3-C6-cycloalkyl, it being possible for the abovementioned alkyl and cycloalkyl radicals to be partially or fully halogenated and/or to have attached to them one, two or three substituents selected from amongst cyano, C1-C4-alkoxy, C1-C4-alkylthio, di(C1-C4-alkyl)amino, C1-C4-alkylcarbonyl, C1-C4-alkoxycarbonyl, C1-C4-alkoxy-C1-C4-alkoxycarbonyl, C1-C4-alkylaminocarbonyl, N,N-di(C1-C4-alkyl)aminocarbonyl or C3-C6-cycloalkyl;
phenyl, phenyl-C1-C6-alkyl, phenylcarbonyl-C1-C6-alkyl, heterocyclyl, heterocyclyl-C1-C6-alkyl or heterocyclylcarbonyl-C1-C6-alkyl, it being possible for the phenyl or heterocyclyl radical of the abovementioned radicals to be partially or fully halogenated and/or to have attached to it one, two or three substituents selected from amongst nitro, cyano, C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy or C1-C4-haloalkoxy;
p is 2, 3 or 4;
q is 1, 2, 3, 4 or 5;
or an agriculturally useful salt thereof.
2. A 3-(4,5-dihydroisoxazol-5-yl)benzoylcyclohexenone of the formula I as claimed in claim 1 , where
R1, R2 are nitro, halogen, cyano, C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C6-haloalkoxy, C1-C6-alkylthio, C1-C6-haloalkylthio, C1-C6-alkylsulfinyl, C1-C6-haloalkylsulfinyl, C1-C6-alkylsulfonyl or C1-C6-haloalkylsulfonyl.
3. A 3-(4,5-dihydroisoxazol-5-yl)benzoylcyclohexenone of the formula I as claimed in claim 1 or 2, where R3 is hydrogen.
4. A 3-(4,5-dihydroisoxazol-5-yl)benzoylcyclohexenone of the formula I as claimed in any of claims 1 to 3, where
R5 is hydrogen, halogen, cyano, nitro, C1-C4-alkyl, C1-C4-alkoxy-C1-C4-alkyl, C1-C4-alkoxycarbonyl-C1-C4-alkyl, C1-C4-alkylthio-C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-cyanoalkyl, C3-C8-cycloalkyl, C1-C4-alkoxy, C1-C4-alkoxy-C2-C4-alkoxy, C1-C4-haloalkoxy, C1-C4-alkylthio, C1-C4-haloalkylthio, di(C1-C4-alkyl)amino, COR8, phenyl or benzyl, it being possible for the two last-mentioned substituents to be partially or fully halogenated and/or to have attached to them one to three of the following groups:
nitro, cyano, C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy or C1-C4-haloalkoxy;
R6 is hydrogen or C1-C4-alkyl.
5. A 3-(4,5-dihydroisoxazol-5-yl)benzoylcyclohexenone of the formula I as claimed in any of claims 1 to 4 , where R5 and R6 are hydrogen.
6. A 3-(4,5-dihydroisoxazol-5-yl)benzoylcyclohexenone of the formula I as claimed in any of claims 1 to 5 , where
R12 is hydroxyl, OR19 or SR19; and
R19 is C1-C6-alkyl, C1-C20-alkylcarbonyl, C1-C6-alkoxycarbonyl, C1-C6-alkylthiocarbonyl, it being possible for the alkyl and alkoxy radicals to be partially or fully halogenated and/or to have attached to them one, two or three substituents selected from amongst cyano, C1-C4-alkoxy, C1-C4-alkylthio, C1-C4-alkylcarbonyl, C1-C4-alkoxycarbonyl or C3-C6-cycloalkyl;
phenyl, phenyl-C1-C4-alkyl, phenylcarbonyl-C1-C4-alkyl, phenylcarbonyl, phenoxycarbonyl, heterocyclyl, heterocyclyl-C1-C4-alkyl, heterocyclylcarbonyl-C1-C4-alkyl, heterocyclyloxycarbonyl, it being possible for the phenyl or heterocyclyl radical of the abovementioned radicals to be partially or fully halogenated and/or have attached to it one, two or three substituents selected from amongst nitro, cyano, C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy or C1-C4-haloalkoxy.
7. A 3-(4,5-dihydroisoxazol-5-yl)benzoylcyclohexenone of the formula I as claimed in any of claims 1 to 6 , where R12 is hydroxyl.
8. A 3-(4,5-dihydroisoxazol-5-yl)benzoylcyclohexenone of the formula I as claimed in any of claims 1 to 7 , where
R13 and R17 independently of one another are hydrogen, C1-C4-alkyl or C1-C4-alkylthio;
R14, R16, R18 independently of one another are hydrogen or methyl;
R15 is hydrogen, hydroxyl, C1-C6-alkyl or di(C1-C6-alkoxy)methyl;
or
R13 and R14 or R14 and R15 or R15 and R18 or R14 and R18 or R17 and R18 together are C1-C5-alkanediyl which can have attached to it one, two or three substituents selected from amongst halogen, cyano, C1-C4-alkyl, C1-C4-haloalkyl or C1-C4-alkoxycarbonyl;
or
R15 and R16 together are an oxygen atom.
9. A process for the preparation of a 3-(4,5-dihydroisoxazol-5-yl)benzoylcyclohexenone of the formula I as claimed in claim 1 , which comprises acylating the cyclohexenone of the formula II where R12═OH, where the variables R13 to R18 have the meanings stated in claim 1 ,
with an activated carboxylic acid IIIα or with a carboxylic acid IIIβ,
where the variables R1 to R7 have the meanings stated in claim 1 and L1 is a nucleophilically displaceable leaving group, and subjecting the acylation product to a rearrangement reaction in the presence of a catalyst to give the compounds I (where R12═OH) .
10. A process for the preparation of a 3-(4,5-dihydroisoxazol-5-yl)benzoylcyclohexenone of the formula I where R12═OR19 or SR19 as claimed in claim 1 , in which a compound of the formula I where R12═OH or SH,
where R1 to R7 and R13 to R18 have the meaning stated in claim 1 is reacted with a compound of the formula V
L2-R19 V
where the variable R19 has the meaning stated in claim 1 and L2 is a nucleophilically displaceable leaving group.
11. A process for the preparation of a 3-(4,5-dihydroisoxazol-5-yl)benzoylcyclohexenone of the formula I where R12=halogen as claimed in claim 1 , in which a compound of the formula I where R12═OH,
where the variables R1 to R7 and R13 to R18 have the meaning stated in claim 1 is reacted with a halogenating agent.
12. A process for the preparation of a 3-(4,5-dihydroisoxazol-5-yl)benzoylcyclohexenone of the formula I where R12=mercapto, OR19 or SR19 as claimed in claim 1 , in which a compound of the formula I where R12=halogen,
where the variables R1 to R7 and R13 to R18 have the meaning stated in claim 1 is reacted with a compound of the formula VI
H2S or HOR19or HSR19 VI
where R19 has the meaning stated in claim 1 , in the presence or absence of a base.
13. A process for the preparation of a 3-(4,5-dihydroisoxazol-5-yl)benzoylcyclohexenone of the formula I where R12═SOR20 or SO2R20 as claimed in claim 1 , in which a compound of the formula I where R12═SR20,
where the variables R1 to R7 and R13 to R18 have the meaning stated in claim 1 , is reacted with an oxidant.
14. A composition comprising a herbicidally active amount of at least one 3-(4,5-dihydroisoxazol-5-yl)benzoylcyclohexenone of the formula I or of an agriculturally useful salt thereof as claimed in claims 1 to 8 and adjuvants conventionally used for the formulation of crop protection products.
15. A process for the preparation of a composition as claimed in claim 14 , which comprises mixing a herbicidally active amount of at least one 3-(4,5-dihydroisoxazol-5-yl)benzoylcyclohexenone of the formula I or of an agriculturally useful salt of I as claimed in claims 1 to 8 and adjuvants conventionally used for the formulation of crop protection products.
16. A method of controlling undesired vegetation, which comprises allowing a herbicidally active amount of at least one 3-(4,5-dihydroisoxazol-5-yl)benzoylcyclohexenone of the formula I or of an agriculturally useful salt thereof as claimed in claims 1 to 8 to act on plants, their environment and/or on seeds.
17. The use of a 3-(4,5-dihydroisoxazol-3-yl)benzoylcyclohexenone of the formula I and/or its agriculturally useful salts as claimed in claims 1 to 8 as herbicide.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
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DE10024107 | 2000-05-18 | ||
DE10024107.7 | 2000-05-18 | ||
DE10024107 | 2000-05-18 | ||
PCT/EP2001/005390 WO2001087856A1 (en) | 2000-05-18 | 2001-05-11 | 3-(4,5-dihydroisoxazole-5-yl)benzoylcyclohexenones and the use thereof as herbicides |
Publications (2)
Publication Number | Publication Date |
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US20030199699A1 true US20030199699A1 (en) | 2003-10-23 |
US6645919B1 US6645919B1 (en) | 2003-11-11 |
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US10/276,225 Expired - Fee Related US6645919B1 (en) | 2000-05-18 | 2001-05-11 | 3-(4,5-Dihydroisoxazol-5-yl)benzoylcyclohexenones and the use thereof as herbicides |
Country Status (9)
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US (1) | US6645919B1 (en) |
EP (1) | EP1284969B1 (en) |
JP (1) | JP2003533516A (en) |
AR (1) | AR029094A1 (en) |
AT (1) | ATE273965T1 (en) |
AU (1) | AU2001262282A1 (en) |
CA (1) | CA2408680A1 (en) |
DE (1) | DE50103331D1 (en) |
WO (1) | WO2001087856A1 (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2016139164A1 (en) * | 2015-03-05 | 2016-09-09 | Bayer Cropscience Aktiengesellschaft | Process for preparing substituted phenylisoxazoline derivatives |
WO2018004223A1 (en) * | 2016-06-27 | 2018-01-04 | (주)목우연구소 | Pyridine-based compound including isoxazoline ring, and use thereof as herbicide |
CN109071887A (en) * | 2016-04-25 | 2018-12-21 | 株式会社普利司通 | Rubber composition |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR032779A1 (en) * | 2000-12-11 | 2003-11-26 | Basf Ag | DERIVATIVES OF CICLOHEXENONA DE BENZAZOLONAS, BENZAZOLONACARBOXILIC ACIDS, AGENTS CONTAINING AT LEAST ONE DERIVATIVE OF CICLOHEXENONE, PROCEDURE TO COMBAT INDESATED GROWTH OF PLANTS AND USE OF SUCH DERIVATIVES AS HERBICIDES |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0811005B1 (en) * | 1995-02-24 | 1999-09-29 | Basf Aktiengesellschaft | Herbicidal benzoyl derivatives |
JP2000016982A (en) * | 1998-06-30 | 2000-01-18 | Kumiai Chem Ind Co Ltd | Quinoline derivative and weedkiller containing the same as active component |
-
2001
- 2001-05-11 AT AT01936353T patent/ATE273965T1/en not_active IP Right Cessation
- 2001-05-11 AU AU2001262282A patent/AU2001262282A1/en not_active Abandoned
- 2001-05-11 CA CA002408680A patent/CA2408680A1/en not_active Abandoned
- 2001-05-11 US US10/276,225 patent/US6645919B1/en not_active Expired - Fee Related
- 2001-05-11 DE DE50103331T patent/DE50103331D1/en not_active Expired - Lifetime
- 2001-05-11 WO PCT/EP2001/005390 patent/WO2001087856A1/en active IP Right Grant
- 2001-05-11 EP EP01936353A patent/EP1284969B1/en not_active Expired - Lifetime
- 2001-05-11 JP JP2001584252A patent/JP2003533516A/en active Pending
- 2001-05-18 AR ARP010102370A patent/AR029094A1/en unknown
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2016139164A1 (en) * | 2015-03-05 | 2016-09-09 | Bayer Cropscience Aktiengesellschaft | Process for preparing substituted phenylisoxazoline derivatives |
CN107406394A (en) * | 2015-03-05 | 2017-11-28 | 拜耳作物科学股份公司 | For the method for the phenyl-isoxazole oxazoline derivative for preparing substitution |
US10604495B2 (en) | 2015-03-05 | 2020-03-31 | Bayer Cropscience Aktiengesellschaft | Process for preparing substituted phenylisoxazoline derivatives |
CN109071887A (en) * | 2016-04-25 | 2018-12-21 | 株式会社普利司通 | Rubber composition |
US20190127559A1 (en) * | 2016-04-25 | 2019-05-02 | Bridgestone Corporation | Rubber composition |
WO2018004223A1 (en) * | 2016-06-27 | 2018-01-04 | (주)목우연구소 | Pyridine-based compound including isoxazoline ring, and use thereof as herbicide |
CN109561682A (en) * | 2016-06-27 | 2019-04-02 | 牧牛研究所株式会社 | Pyridine compounds and their comprising isoxazoline ring and its purposes as herbicide |
AU2017287716B2 (en) * | 2016-06-27 | 2019-08-08 | Korea Research Institute Of Chemical Technology | Pyridine-based compound including isoxazoline ring, and use thereof as herbicide |
Also Published As
Publication number | Publication date |
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US6645919B1 (en) | 2003-11-11 |
WO2001087856A1 (en) | 2001-11-22 |
EP1284969A1 (en) | 2003-02-26 |
DE50103331D1 (en) | 2004-09-23 |
EP1284969B1 (en) | 2004-08-18 |
CA2408680A1 (en) | 2002-11-12 |
ATE273965T1 (en) | 2004-09-15 |
JP2003533516A (en) | 2003-11-11 |
AR029094A1 (en) | 2003-06-04 |
AU2001262282A1 (en) | 2001-11-26 |
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