US20030181983A1 - Spinal disc annulus reconstruction method and spinal disc annulus stent - Google Patents
Spinal disc annulus reconstruction method and spinal disc annulus stent Download PDFInfo
- Publication number
- US20030181983A1 US20030181983A1 US10/392,733 US39273303A US2003181983A1 US 20030181983 A1 US20030181983 A1 US 20030181983A1 US 39273303 A US39273303 A US 39273303A US 2003181983 A1 US2003181983 A1 US 2003181983A1
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- aperture
- annulus
- disc
- stent
- comprised
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- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2210/0014—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof using shape memory or superelastic materials, e.g. nitinol
- A61F2210/0019—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof using shape memory or superelastic materials, e.g. nitinol operated at only one temperature whilst inside or touching the human body, e.g. constrained in a non-operative shape during surgery, another temperature only occurring before the operation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
- A61F2230/0017—Angular shapes
- A61F2230/0026—Angular shapes trapezoidal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0063—Three-dimensional shapes
- A61F2230/0093—Umbrella-shaped, e.g. mushroom-shaped
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00011—Metals or alloys
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S606/00—Surgery
- Y10S606/907—Composed of particular material or coated
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S623/00—Prosthesis, i.e. artificial body members, parts thereof, or aids and accessories therefor
- Y10S623/902—Method of implanting
Definitions
- the annulus stent may be made from:
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Transplantation (AREA)
- Neurology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Physical Education & Sports Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Prostheses (AREA)
Abstract
A surgical method of repair and reconstruction of the spinal disc wall (annulus) after surgical invasion or pathologic rupture, incorporating suture closure, or stent insertion and fixation, designed to reduce the failure rate of conventional surgical procedures on the spinal discs. The design of the spinal disc annulus stent allows ingrowth of normal cells of healing in an enhanced fashion strengthening the normal reparative process.
Description
- This application is a continuation of co-pending U.S. Ser. No. 09/947,078, filed Sep. 5, 2001 (pending); which is a continuation of U.S. Ser. No. 09/484,706, filed Jan. 18, 2000 (now abandoned); which claims the benefit of U.S. Provisional Application No. 60/160,710, filed Oct. 20, 1999.
- The invention generally relates to a surgical method of intervertebral disc wall reconstruction with a related annulus stent augmenting the repair. The effects of said reconstruction are restoration of disc wall integrity and reduction of the failure rate (3-21%) of a common surgical procedure (disc fragment removal or discectomy). This surgical procedure is performed about 390,000 times annually in the United States.
- The spinal column is formed from a number of vertebrae, which in their normal state are separated from each other by cartilaginous intervertebral discs. The intervertebral disc acts in the spine as a crucial stabilizer, and as a mechanism for force distribution between the vertebral bodies. Without the disc, collapse of the intervertebral space occurs in conjunction with abnormal joint mechanics and premature development of arthritic changes.
- The normal intervertebral disc has an outer ligamentous ring called the annulus surrounding the nucleus pulposus. The annulus binds the adjacent vertebrae together and is constituted of collagen fibers that are attached to the vertebrae and cross each other so that half of the individual fibers will tighten as the vertebrae are rotated in either direction, thus resisting twisting or torsional motion. The nucleus pulposus is constituted of loose tissue, having about 85% water content, which moves about during bending from front to back and from side to side.
- As people age, the annulus tends to thicken, desicate, and become more rigid. The nucleus pulposus, in turn, becomes more viscous and less fluid and sometimes even dehydrates and contracts. The annulus also becomes susceptible to fracturing or fissuring. These fractures tend to occur all around the circumference of the annulus and can extend from both the outside of the annulus inwards, and the interior outward. Occasionally, a fissure from the outside of the annulus meets a fissure from the inside and results in a complete rent or tear through the annulus fibrosis. In situations like these, the nucleus pulposus may extrude out through the annulus wall. The extruded material, in turn, can impinge on the spinal cord or on the spinal nerve rootlet as it exits through the intervertebral disc foramen, resulting in a condition termed ruptured disc or herniated disc
- In the event of annulus rupture, the inner-nucleus component migrates along the path of least resistance forcing the fissure to open further, allowing migration of the nucleus pulposus through the wall of the disc, with resultant nerve compression and leakage of chemicals of inflammation into the space around the adjacent nerve roots supplying the extremities, bladder, bowel and genitalia. The usual effect of nerve compression and inflammation is intolerable back or neck pain, radiating into the extremities, with accompanying numbness, weakness, and in late stages, paralysis and muscle atrophy, and/or bladder and bowel incontinence. Additionally, injury, disease or other degenerative disorders may cause one or more of the intervertebral discs to shrink, collapse, deteriorate or become displaced, herniated, or otherwise damaged.
- The surgical standard of care for treatment of herniated, displaced or ruptured intervertebral discs is fragment removal and nerve decompression without a requirement to reconstruct the annular wall. While results are currently acceptable, they are not optimal. Various authors report 3.1-21% recurrent disc herniation, representing a failure of the primary procedure and requiring re-operation for the same condition. An estimated 10% recurrence rate results in 39,000 re-operations in the United States each year.
- An additional method of relieving the symptoms is thermal annuloplasty, involving the heating of sub-annular zones in the non-herniated painful disc, seeking pain relief, but making no claim of reconstruction of the ruptured, discontinuous annulus wall.
- There is currently no known method of annulus reconstruction, either primarily or augmented with an annulus stent.
- The present invention provides methods and related materials for reconstruction of the disk wall in cases of displaced, herniated, ruptured, or otherwise damaged intervertebral discs.
- In a preferred form, one or more mild biodegradable surgical sutures are placed at about equal distances along the sides of a pathologic aperture in the ruptured disc wall (annulus) or along the sides of a surgical incision in the weakened, thinned disc annulus.
- Sutures are then tied in such fashion as to draw together the sides of the aperture, effecting reapproximation or closure of the opening, to enhance natural healing and subsequent reconstruction by natural tissue (fibroblasts) crossing the now surgically narrowed gap in the disc annulus.
- A 25-30% reduction in the rate of recurrence of disc nucleus herniation through this aperture, has been achieved using this method.
- In another embodiment, the method can be augmented by placement of a patch of human muscle fascia (the membrane covering the muscle) or any other autograft or allograft acting as a bridge in and across the aperture, providing a platform for traverse of fibroblasts or other normal cells of repair existing in and around the various layers of the disc annulus, prior to closure of the aperture.
- A 30-50% reduction in the rate of recurrence of disc herniation has been achieved using the aforementioned fascial augmentation with this embodiment.
- Having demonstrated that human muscle fascia is adaptable for annular reconstruction, other biocompatible membranes can be employed as a bridge, stent, patch or barrier to subsequent migration of the disc nucleus through the aperture. Such biocompatible materials may be, for example, a medical grade biocompatible fabric, biodegradable polymeric sheets, or form fitting or non-form fitting fillers for the cavity created by removal of a portion of the disc nucleus in the course of the disc fragment removal or discectomy. The prosthetic material can be placed in and around the intervertebral space, created by removal of the degenerated disc fragments.
- FIG. 1 shows a perspective view of the annulus stent.
- FIG. 2 shows a front view of the annulus stent.
- FIG. 3 shows a side view of the annulus stent.
- FIG. 4A-4C show a front view of various alternative embodiments of the annulus stent.
- FIG. 5A-5B shows the alternative embodiment of a pyramid shaped annulus stent.
- FIG. 6A-6B shows the alternative embodiment of a coned shaped annulus stent.
- FIG. 7 shows the primary closure of the opening in the disc annulus, without an intervertebral or subannular stent.
- FIG. 8A-8B shows the primary closure with a stent in generic form.
- FIG. 9 shows a method of suturing the annulus stent into the disc annulus, utilizing sub-annular fixation points.
- FIG. 10A-10B show the annulus stent with flexible bladder being expanded into the disc annulus.
- FIG. 11A-11D show the annulus stent being inserted into the disc annulus.
- FIG. 12A-12B show the annulus stent with the flexible bladder being expanded by injection.
- The present invention provides methods and related materials for reconstruction of the disk wall in cases of displaced, herniated, ruptured, or otherwise damaged intervertebral discs.
- In one embodiment of the present invention, as shown in FIG. 7, a damaged
annulus 42 is repaired by use ofsurgical sutures 40. One or moresurgical sutures 40 are placed at about equal distances along the sides of apathologic aperture 44 in the rupturedannulus 42. Reapproximation or closure of theaperture 44 is accomplished by tying thesutures 40 in such a fashion that the sides of theaperture 44 are drawn together. The reapproximation or closure of theaperture 44 enhances the natural healing and subsequent reconstruction by the natural tissue crossing the now surgically narrowed gap in theannulus 42. Preferably, thesurgical sutures 40 are biodegradable, but permanent non-biodegradable may be utilized. - Additionally, to repair a weakened or thinned
disc annulus 42, a surgical incision is made along the weakened or thinned region of theannulus 42 and one or moresurgical sutures 40 are placed at about equal distances along the sides of the incision. Reapproximation or closure of the incision is accomplished by tying thesutures 40 in such a fashion that the sides of the incision are drawn together. The reapproximation or closure of the incision enhances the natural healing and subsequent reconstruction by the natural tissue crossing the now surgically narrowed gap in theannulus 42. Preferably, thesurgical sutures 40 are biodegradable, but permanent non-biodegradable materials may be utilized. - In an alternative embodiment, the method can be augmented by the placement of a patch of human muscle fascia or any other autograft, allograft or xenograft in and across the
aperture 44. The patch acts as a bridge in and across the aperture, providing a platform for traverse of fibroblasts or other normal cells of repair existing in and around the various layers of the disc annulus, prior to closure of the aperture. - In a further embodiment, as shown in FIG. 8, a biocompatible membrane can be employed as an
annulus stent 10, being placed in and across theaperture 44. Theannulus stent 10 acts as a bridge in and across theaperture 44, providing a platform for a traverse of fibroblasts or other normal cells of repair existing in and around the various layers of the disc annulus, prior to closure of theaperture 44. - In a preferred embodiment, as shown in FIGS.1-3, the
annulus stent 10 comprises a centralizedvertical extension 12, with anupper section 14 and alower section 16. The centralizedvertical extension 12 can be trapezoid in shape through the width and may be from about 8 mm -12 mm in length. - Additionally, the
upper section 14 of the centralizedvertical extension 12 may be any number of different shapes, as shown in FIGS. 4A and 4B, with the sides of theupper section 14 being curved or with theupper section 14 being circular in shape. Furthermore, theannulus stent 10 may contain a recess between theupper section 14 and thelower section 16, enabling theannulus stent 10 to form a compatible fit with the edges of theaperture 44. - The
upper section 14 of the centralizedvertical extension 12 can comprise aslot 18, where theslot 18 forms an orifice through theupper section 14. Theslot 18 is positioned within the upper section such that 14 it traverses the upper section's 14 longitudinal axis. Theslot 18 is of such a size and shape that sutures, tension bands, staples or any other type of fixation device known in the art may be passed through, to affix theannulus stent 10 to thedisc annulus 44. - In an alternative embodiment, the
upper section 14 of the centralizedvertical extension 12 may be perforated. The perforatedupper section 14 contains a plurality of holes which traverse the upper section's 14 longitudinal axis. The perforations are of such a size and shape that sutures, tension bands, staples or any other type of fixation device known in the art may be passed through, to affix theannulus stent 10 to thedisc annulus 44. - The
lower section 16 can comprise a pair of lateral extensions, a leftlateral extension 20 and a rightlateral extension 22. Thelateral extensions inside edge 24, anoutside edge 26, anupper surface 28, and alower surface 30. Thelateral extensions inside edge 24 is attached to thelower section 16 and is about the same length as thelower section 16. Theoutside edge 26 can be about 8 mm -16 mm in length. Theinside edge 24 and thelower section 16 meet to form a horizontal plane, essentially perpendicular to the centralizedvertical extension 12. Theupper surface 28 of thelateral extensions annulus stent 10 may be from about 3 mm-5 mm. - Additionally, the
upper surface 28 of thelateral extensions disc annulus 40 and to resist expulsion through theaperture 44. - In an alternative embodiment, as shown in FIG. 4B, the
lateral extensions inside edge 24 than at theoutside edge 26. - In a preferred embodiment, the
annulus stent 10 is a solid unit, formed from one or more of the flexible resilient biocompatible or bioresorbable materials well know in the art. - For example, the annulus stent may be made from:
- a porous matrix or mesh of biocompatible and bioresorbable fibers acting as a scaffold to regenerate disc tissue and replace annulus fibrosus as disclosed in, for example, U.S. Pat. Nos. 5,108,438 (Stone) and 5,258,043 (Stone);
- a strong network of inert fibers intermingled with a bioresorbable (or biosabsorable) material which attracts tissue ingrowth as disclosed in, for example, U.S. Pat. No. 4,904,260 (Ray et al.);
- a biodegradable substrate as disclosed in, for example, U.S. Pat. No. 5,964,807 (Gan at al.); or
- a expandable polytetrafluoroethylene (ePTFE), as used for conventional vascular grafts, such as those sold by W. L. Gore and Associates, Inc. under the trademarks GORE-TEX and PRECLUDE, or by Impra, Inc. under the trademark IMPRA.
- Furthermore, the
annulus stent 10, may contain hygroscopic material for a controlled limited expansion of theannulus stent 10 to fill the evacuated disc space cavity. - Additionally, the
annulus stent 10 may comprise materials to facilitate regeneration of disc tissue, such as bioactive silica-based materials which assist in regeneration of disc tissue as disclosed in U.S. Pat. No. 5,849,331 (Ducheyne, et al.), or other tissue growth factors well known in the art. - In further embodiments, as shown in FIGS.5-6, the left and right
lateral extensions lateral extensions lateral extensions aperture 44, then to expand conforming to the shape of the annulus' 42 inner wall. - Alternatively, a compressible core may be attached to the
lower surface 30 of thelateral extensions lateral extensions aperture 44, then to expand conforming to the shape of the annulus' 42 inner wall and to the cavity created by pathologic extrusion or surgical removal of the disc fragment. - In a preferred method of use, as shown in FIGS.10A- 10D, the
lateral extensions aperture 44 of thedisc annulus 40. Theannulus stent 10 is then inserted into theaperture 44, where thelateral extensions upper surface 28 contouring to the inside surface of thedisc annulus 40. Theupper section 14 is positioned within theaperture 44 so that theannulus stent 10 may be secured to thedisc annulus 40, using means well known in the art. - In an alternative method, where the length of the
aperture 44 is less than the length of theoutside edge 26 of theannulus stent 10, theannulus stent 10 must be inserted laterally into theaperture 44. Thelateral extensions annulus stent 10 is laterally inserted into theaperture 44. Theannulus stent 10 is then rotated inside thedisc annulus 40, such that theupper section 14 is pulled back through theaperture 44. Thelateral extensions upper surface 28 contouring to the inside surface of thedisc annulus 40. Theupper section 14 is positioned within theaperture 44 such that theannulus stent 10 may be secured to the disc annulus, using means well known in the art. - In an alternative method of securing the
annulus stent 10 in theaperture 44, as shown in FIG. 9, a firstsurgical screw 50 and secondsurgical screw 52, with eye holes 53 located at the top of thescrews adjacent vertebrae annulus stent 10. After insertion of theannulus stent 10 into theaperture 44, a suture is passed down though thedisc annulus 40, adjacent to theaperture 44, through theeye hole 53 on thefirst screw 50 then back up through thedisc annulus 40 and through theorifice 18 on theannulus stent 10. This is repeated for thesecond screw 52, after which the suture is secured. One or moresurgical sutures 40 are placed at about equal distances along the sides of theaperture 44 in thedisc annulus 42. Reapproximation or closure of theaperture 44 is accomplished by tying thesutures 40 in such a fashion that the sides of theaperture 44 are drawn together. The reapproximation or closure of theaperture 44 enhances the natural healing and subsequent reconstruction by the natural tissue crossing the now surgically narrowed gap in theannulus 42. Preferably, thesurgical sutures 40 are biodegradable but permanent nonbiodegradable forms may be utilized. This method should decrease the strain on thedisc annulus 40 adjacent to theaperture 44, precluding the tearing of the sutures through thedisc annulus 40. - It is anticipated that fibroblasts will engage the fibers of the polymer or fabric of the intervertebral disc stent, forming a strong wall duplicating the currently existing condition of healing seen in the normal reparative process.
- In an additional embodiment, as shown in FIGS.10A-B, a
flexible bladder 60 is attached to thelower surface 30 of theannulus stent 10. Theflexible bladder 60 comprises aninternal cavity 62 surrounded by amembrane 64, where themembrane 64 is made from a thin flexible biocompatible material. Theflexible bladder 60 is attached to thelower surface 28 of theannulus stent 10 in an unexpanded condition. Theflexible bladder 60 is expanded by injecting a biocompatible fluid or expansive foam, as known in the art, into theinternal cavity 62. The exact size of theflexible bladder 60 can be varied for different individuals. The typical size of an adult nucleus is 2 cm in the semi-minor axis, 4 cm in the semi-major axis and 1.2 cm in thickness. - In an alternative embodiment, the
membrane 64 is made of a semi-permeable biocompatible material. - In a preferred embodiment, a hydrogel is injected into the internal cavity of the
flexible bladder 28. A hydrogel is a substance formed when an organic polymer (natural or synthetic) is cross-linked via covalent, ionic, or hydrogen bonds to create a three-dimensional open-lattice structure which entraps water molecules to form a gel. The hydrogel may be used in either the hydrated or dehydrated form. - In a method of use, where the
annulus stent 10 has been inserted into the aperture, as has been previously described and shown in FIGS. 12 A-b, an injection instrument, as known in the art, such as a syringe, is used to inject the biocompatible fluid or expansive foam into theinternal cavity 62 of theflexible bladder 60. The biocompatible fluid or expansive foam is injected through theannulus stent 10 into the internal cavity of theflexible bladder 28. Sufficient material is injected into theinternal cavity 62 to expand theflexible bladder 60 to fill the void in the intervertebral disc cavity. The use of theflexible bladder 60 is particularly useful when it is required to remove all or part of the intervertebral disc nucleus. - The surgical repair of an intervertebral disc may require the removal of the entire disc nucleus, being replaced with an implant, or the removal of a portion of the disc nucleus thereby leaving a void in the intervertebral disc cavity. The
flexible bladder 60 allows for the removal of only the damaged section of the disc nucleus, with the expandedflexible bladder 60 filling the resultant void in the intervertebral disc cavity. A major advantage of theannulus stent 10 with theflexible bladder 60 is that the incision area in the annulus can be reduced in size as there is no need for the insertion of an implant into the intervertebral disc cavity. - In an alternative method of use, a dehydrated hydrogel is injected into the
internal cavity 28 of theflexible bladder 60. Fluid, from the disc nucleus, passes through thesemi-permeable membrane 64 hydrating the dehydrated hydrogel. As the hydrogel absorbs the fluid the flexible bladder expands 60, filling the void in the intervertebral disc cavity. - All patents referred to or cited herein are incorporated by reference in their entirety to the extent they are not inconsistent with the explicit teachings of this specification, including; U.S. Pat. No. 5,108,438 (Stone), U.S. Pat. No. 5,258,043 (Stone), U.S. Pat. No. 4,904,260 (Ray et al.), U.S. Pat. No. 5,964,807 (Gan et al.), U.S. Pat. No. 5,849,331 (Ducheyne et al.), U.S. Pat. No. 5,122,154 (Rhodes), U.S. Pat. No. 5,204,106 (Schepers at al.), U.S. Pat. No. 5,888,220 (Felt et al.) and U.S. Pat. No. 5,376,120 (Sarver et al.).
- It should be understood that the examples and embodiments described herein are for illustrative purposes only and that various modifications or changes in light thereof will be suggested to person skilled in the art to be included within the spirit and preview of this application and the scope of the appended claims.
Claims (23)
1. A method for treating an intervertebral disc having an aperture in the annulus fibrosis, wherein the aperture provides a pathway for the migration of intradiscal material from the subannular space, the method comprising the steps of:
providing a device in the subannular space having a dimension that at least partially spans said aperture, thereby providing a barrier restricting the migration of intradiscal material through the aperture; and
acutely securing said device in said subannular space to enhance healing.
2. The method of claim 1 wherein the device is comprised at least in part of a shape memory material.
3. The method of claim 1 , wherein the device is comprised at least in part of biocompatible fabric.
4. The method of claim 1 , wherein the device is at least in part bioabsorbable.
5. The method of claim 1 , further comprising the step of treating the annulus tissue surrounding the aperture to reduce the relative motion thereof.
6. The method of claim 5 , further comprising the step of reapproximating the aperture.
7. The method of claim 1 , wherein the device further comprises at least one fixation element for attaching the device to the annulus.
8. The method of claim 6 , wherein the device further comprises at least one element for reapproximating the aperture.
9. The method of claim 1 , wherein the aperture is pathologic.
10. The method of claim 1 , wherein the aperture is formed at least in part by a surgical incision.
11. A method for treating an intervertebral disc having an aperture in the annulus fibrosis, wherein the method of claim 1 is performed following discectomy.
12. The method of claim 1 , further comprising the step of applying sutures to acutely stabilize said device.
13. The method of claim 12 , wherein said device is comprised at least in part from autograft.
14. The method of claim 13 , wherein said autograft is muscle fascia.
15. The method of claim 12 , wherein said device is comprised at least in part from allograft.
16. The method of claim 12 , wherein said device is comprised at least in part from a biocompatible membrane.
17. The method of claim 16 , wherein said biocompatible membrane is a medical grade biocompatible fabric.
18. The method of claim 16 , wherein said biocompatible membrane is a medical grade polymeric sheet.
19. The method of claim 1 , wherein said patch is applied at least in part in said aperture.
20. The method of claim 19 , wherein said patch is a filler.
21. The method of claim 20 , wherein said filler is at least in part form-fitting.
22. The method of claim 20 , wherein said filler is at least in part non-form-fitting.
23. The method of claim 1 , further comprising the step of placing sutures at about equal distances along the sides of the aperture.
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US10/134,746 Abandoned US20020120337A1 (en) | 1999-10-20 | 2002-04-30 | Intervertebral disc annulus repair device |
US10/165,962 Abandoned US20020151980A1 (en) | 1999-10-20 | 2002-06-11 | Intervertebral disc annulus repair device |
US10/365,730 Expired - Lifetime US6984247B2 (en) | 1999-10-20 | 2003-02-12 | Spinal disc annulus reconstruction method and spinal disc annulus stent |
US10/392,731 Expired - Lifetime US7033395B2 (en) | 1999-10-20 | 2003-03-19 | Spinal disc annulus reconstruction method and spinal disc annulus stent |
US10/392,739 Expired - Fee Related US7189235B2 (en) | 1999-10-20 | 2003-03-19 | Spinal disc annulus reconstruction method and spinal disc annulus stent |
US10/392,733 Abandoned US20030181983A1 (en) | 1999-10-20 | 2003-03-19 | Spinal disc annulus reconstruction method and spinal disc annulus stent |
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US10/394,266 Abandoned US20030220690A1 (en) | 1999-10-20 | 2003-03-24 | Intervertebral disc annulus repair devices and methods |
US10/394,008 Abandoned US20030220693A1 (en) | 1999-10-20 | 2003-03-24 | Intervertebral disc annulus repair devices and methods |
US10/394,061 Abandoned US20030220694A1 (en) | 1999-10-20 | 2003-03-24 | Intervertebral disc annulus repair devices and methods |
US10/985,735 Abandoned US20050149197A1 (en) | 1999-10-20 | 2004-11-10 | Spinal disc annulus repair device |
US11/313,738 Expired - Fee Related US8048160B2 (en) | 1999-10-20 | 2005-12-22 | Intervertebral disc annulus stent |
US11/351,657 Abandoned US20060129245A1 (en) | 1999-10-20 | 2006-02-10 | Intervertebral disc annulus stent |
US11/355,426 Expired - Fee Related US7670379B2 (en) | 1999-10-20 | 2006-02-16 | Spinal disc annulus reconstruction method |
US11/376,301 Abandoned US20060161258A1 (en) | 1999-10-20 | 2006-03-16 | Spinal disc annulus reconstruction method and spinal disc annulus stent |
US11/398,583 Abandoned US20060241773A1 (en) | 1999-10-20 | 2006-04-06 | Spinal disc annulus reconstruction method and spinal disc annulus stent |
US11/410,420 Abandoned US20060190085A1 (en) | 1999-10-20 | 2006-04-25 | Spinal disc annulus repair device |
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US11/558,034 Expired - Fee Related US7909879B2 (en) | 1999-10-20 | 2006-11-09 | Intervertebral disc annulus stent |
US11/841,513 Expired - Fee Related US7776096B2 (en) | 1999-10-20 | 2007-08-20 | Intervertebral disc annulus stent |
US11/843,425 Abandoned US20080033561A1 (en) | 1999-10-20 | 2007-08-22 | Intervertebral Disc Annulus Stent |
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US10/085,040 Abandoned US20020111688A1 (en) | 1999-10-20 | 2002-03-01 | Intervertebral disc annulus stent |
US10/134,746 Abandoned US20020120337A1 (en) | 1999-10-20 | 2002-04-30 | Intervertebral disc annulus repair device |
US10/165,962 Abandoned US20020151980A1 (en) | 1999-10-20 | 2002-06-11 | Intervertebral disc annulus repair device |
US10/365,730 Expired - Lifetime US6984247B2 (en) | 1999-10-20 | 2003-02-12 | Spinal disc annulus reconstruction method and spinal disc annulus stent |
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US10/392,739 Expired - Fee Related US7189235B2 (en) | 1999-10-20 | 2003-03-19 | Spinal disc annulus reconstruction method and spinal disc annulus stent |
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US10/394,266 Abandoned US20030220690A1 (en) | 1999-10-20 | 2003-03-24 | Intervertebral disc annulus repair devices and methods |
US10/394,008 Abandoned US20030220693A1 (en) | 1999-10-20 | 2003-03-24 | Intervertebral disc annulus repair devices and methods |
US10/394,061 Abandoned US20030220694A1 (en) | 1999-10-20 | 2003-03-24 | Intervertebral disc annulus repair devices and methods |
US10/985,735 Abandoned US20050149197A1 (en) | 1999-10-20 | 2004-11-10 | Spinal disc annulus repair device |
US11/313,738 Expired - Fee Related US8048160B2 (en) | 1999-10-20 | 2005-12-22 | Intervertebral disc annulus stent |
US11/351,657 Abandoned US20060129245A1 (en) | 1999-10-20 | 2006-02-10 | Intervertebral disc annulus stent |
US11/355,426 Expired - Fee Related US7670379B2 (en) | 1999-10-20 | 2006-02-16 | Spinal disc annulus reconstruction method |
US11/376,301 Abandoned US20060161258A1 (en) | 1999-10-20 | 2006-03-16 | Spinal disc annulus reconstruction method and spinal disc annulus stent |
US11/398,583 Abandoned US20060241773A1 (en) | 1999-10-20 | 2006-04-06 | Spinal disc annulus reconstruction method and spinal disc annulus stent |
US11/410,420 Abandoned US20060190085A1 (en) | 1999-10-20 | 2006-04-25 | Spinal disc annulus repair device |
US11/521,473 Expired - Fee Related US7670380B2 (en) | 1999-10-20 | 2006-09-15 | Intervertebral disc annulus stent |
US11/558,034 Expired - Fee Related US7909879B2 (en) | 1999-10-20 | 2006-11-09 | Intervertebral disc annulus stent |
US11/841,513 Expired - Fee Related US7776096B2 (en) | 1999-10-20 | 2007-08-20 | Intervertebral disc annulus stent |
US11/843,425 Abandoned US20080033561A1 (en) | 1999-10-20 | 2007-08-22 | Intervertebral Disc Annulus Stent |
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