US20020100483A1 - Non-destructive method for evaluating cancellous bone strength of allograft tissue - Google Patents
Non-destructive method for evaluating cancellous bone strength of allograft tissue Download PDFInfo
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- US20020100483A1 US20020100483A1 US10/045,276 US4527601A US2002100483A1 US 20020100483 A1 US20020100483 A1 US 20020100483A1 US 4527601 A US4527601 A US 4527601A US 2002100483 A1 US2002100483 A1 US 2002100483A1
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/4833—Physical analysis of biological material of solid biological material, e.g. tissue samples, cell cultures
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2203/00—Investigating strength properties of solid materials by application of mechanical stress
- G01N2203/0058—Kind of property studied
- G01N2203/0089—Biorheological properties
Definitions
- This application is directed to a method for quickly and easily evaluating the strength of cancellous bone. More specifically, this application is directed to a non-destructive method for quickly and easily evaluating the strength of dense cancellous bone to determine the suitability of the cancellous bone for a particular surgical application.
- the strength and quality of bone varies greatly from donor to donor, and also from location to location within a single donor.
- studies have shown that the apparent density of cancellous bone decreases significantly with age and that the apparent density of bone varies between genders. As the apparent density of bone decreases, the compressive strength, and thus the load bearing capacity, of the bone also decreases.
- the compressive strength of allograft bone can be determined using the appropriate machinery to subject the bone to a compressive force until failure occurs.
- this method is impracticable. Firstly, using this method, the particular specimen tested is destroyed. Secondly, the compressive strength of the specimen tested is not determinative of the compressive strength of cancellous bone from a different, or even the same donor.
- cancellous bone allografts are used in a variety of surgical procedures including spinal fusion procedures, e.g., fusion procedures in the cervical region of the spine.
- spinal fusion procedures e.g., fusion procedures in the cervical region of the spine.
- an allograft is positioned between adjacent vertebral endplates to retain and support the vertebrae at a fixed location with respect to each other. It is imperative to the success of such a procedure that the allograft be capable of withstanding the compressive forces generated by the vertebrae.
- an improved method for determining the strength of allografts formed of cancellous bone is needed which does not destroy the bone and which can be easily and quickly performed by a technician.
- a non-destructive method for evaluating the strength of cancellous bone includes the steps of performing at least two of the following test on each cancellous bone of a population of cancellous bones, namely, a manual compression test, an apparent density test, and an appearance test; determining a compressive strength for each cancellous bone based on the two tests performed; comparing the determined compressive strength of each cancellous bone against a predetermined compressive strength requirement; and eliminating a subset of cancellous bone from the population of cancellous bone, which subset of cancellous bone fails to meet the predetermined compressive strength requirement.
- the manual compression test includes the steps of manually compressing each cancellous bone to make a subjective determination of the compressive strength of each cancellous bone and removing a cancellous bone from the population of cancellous bones when the manually compressed cancellous bone appreciably deforms.
- the appearance test includes the steps of assessing a quality of each cancellous bone based on their individual appearance and assigning each cancellous bone with a grade which designates a subjective quality assessment of each cancellous bone.
- the apparent density test includes the steps of cleaning each cancellous bone, freeze drying each cancellous bone, measuring the dimensions of each cancellous bone to determine a volume thereof, weighing each cancellous bone, determining an apparent density for each cancellous bone, and determining the compressive strength of each cancellous bone based on the apparent density.
- the presently disclosed non-destructive method for evaluating cancellous bone strength of allograft tissue includes three separate tests which are performed by a technician during preparation of the allograft. These tests include the appearance test, the manual compression test and the apparent density test. Each test is used to determine or identify a subset of cancellous bone allografts which have better strength than those of the overall population of cancellous allografts.
- a cancellous bone allograft is cut from cancellous bone of a donor into the desired configuration which may be a cylindrical dowel, a wedge, a rectangular spacer, etc.
- the donor bone may be cleaned using an external spray to remove soft tissue from the external surface of the bone.
- the allograft should be cut such that the first facing cuts (which will become the top or bottom loading surfaces of the allograft) are perpendicular to the trabecular orientation in the bone. Typically, these facing cuts will be perpendicular to the long axis of the bone.
- the graft will be loaded in a similar orientation to the loading orientation of the graft during the donor's lifetime as disclosed in the article “Orienting Cancellous Bone For The Preparation of Graftech Cervical Spacer” by Todd Boyce, the entire contents of which is hereby incorporated by reference. After the allograft has been cut into a desired configuration, a technician will perform each of the above-identified tests and evaluations.
- the manual compression test may be performed prior to or after cleaning of the bone but must be performed prior to freeze drying the allograft.
- the cancellous bone allograft is compressed between the technician's fingers to make a subjective determination of the hardness and the compressive strength of the cancellous bone allograft.
- the manual compression test provides a first level of allograft screening. If the allograft compresses appreciably or deforms greatly between the fingers of a technician, the allograft is discarded. Discarded allograft bone can be used to form other osteoinductive materials or compounds.
- trained technicians can consistently eliminate grafts which fall below a minimum required compressive strength.
- the minimum required compressive strength of the graft will vary according to the intended use of the graft, e.g., the minimum required compressive strength of a graft for use in the cervical spine is approximately 500 newtons.
- the technician After the manual compression test has been conducted and the cancellous bone allograft has been cleaned by removing the blood and marrow from the bone, the technician performs the appearance test. In conducting the appearance test, a technician assesses the quality of the allograft based on its appearance to determine if the allograft meets the standard of “dense cancellous bone”. The technician will assign the load bearing allograft a rating using a Grade 1 to Grade 5 scale (1 being the most suitable for allograft use and 5 being the least suitable) to designate the technician's subjective quality assessment of the cancellous bone allograft.
- an apparent density test of the cancellous bone allograft will be conducted to estimate the strength of the allograft. More specifically, each allograft is weighed and its dimensions are measured to determine the volume of the allograft (including the volume of the pore spaces). Knowing the weight and volume, the apparent density of the allograft can be easily determined.
- the apparent density test of each allograft should be conducted after the allograft has been cleaned, the cleaning solution has been removed from the allograft and the allograft has been freeze dried. Alternately, the apparent density test can be conducted prior to freeze drying the allograft.
- each allograft need not be measured independently but rather the volume of the allograft can be determined based on the pre-selected dimensions of the allograft. If the apparent density test is conducted prior to freeze drying, some process should be used to reduce the water content in the allograft bone to a predetermined level such that the volume of water remaining in the cancerous bone can be factored into the apparent density measurement. Using known data gotten through prior testing of a statistically significant number of cancellous bone samples, a graph can be plotted comparing compressive strength of cancellous bone v. apparent density of the cancerous bone.
- the compressive strength of a cancellous bone graft can be estimated after the apparent density of the graft has been determined. If the allograft has passed the manual compression test, the appearance test and has the required apparent density, the allograft is acceptable for allograft use.
- the order of the tests may be varied.
- the degree to which the bone has been cleaned, freeze dried, or prepared before each or all of the tests are conducted may vary, e.g., the cancellous bone need not be cleaned or it may undergo a complete cleaning cycle before conducting any one or all of the above-identified tests.
- each of these tests may be used individually or in conjunction with any one or both of the remaining tests to eliminate unsuitable bone from consideration as graft bone.
- the apparent density test may be used alone or in combination with only the manual compression test to identify a subset of cancellous bone allografts which meet or do not meet necessary strength requirements. Therefore, the above description should not be construed as limiting, but merely as exemplifications of preferred embodiments. Those skilled in the art will envision other modifications within the scope and spirit of the claims appended hereto.
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Abstract
A non-destructive method for evaluating the strength of cancellous bone, includes the steps of performing at least two of the following test on each cancerous bone of a population of cancellous bones, namely, a manual compression test, an apparent density test, and an appearance test; determining a compressive strength for each cancellous bone based on the two tests performed; comparing the determined compressive strength of each cancellous bone against a predetermined compressive strength requirement; and eliminating a subset of cancellous bone from the population of cancellous bone, which subset of cancerous bone fails to meet the predetermined compressive strength requirement.
Description
- The present application claims priority to U.S. provisional application Serial No. 60/243,170 filed Oct. 25, 2000, the entire contents of which is hereby incorporated by reference.
- 1. Technical Field
- This application is directed to a method for quickly and easily evaluating the strength of cancellous bone. More specifically, this application is directed to a non-destructive method for quickly and easily evaluating the strength of dense cancellous bone to determine the suitability of the cancellous bone for a particular surgical application.
- 2. Background of Related Art
- The use of bone allografts in surgical procedures for repairing bone fractures, torn ligaments, spinal disorders, etc., is well known in the art. Examples of such allografts, designed specifically for use in spinal fusion procedures, are disclosed in U.S. provisional application serial Nos. 60/220,941, filed Jul. 26, 2000, and 60/158,074, filed Oct. 7, 1999. Both of these applications are incorporated herein by reference in their entirety.
- The strength and quality of bone, particularly cancellous bone, varies greatly from donor to donor, and also from location to location within a single donor. For example, studies have shown that the apparent density of cancellous bone decreases significantly with age and that the apparent density of bone varies between genders. As the apparent density of bone decreases, the compressive strength, and thus the load bearing capacity, of the bone also decreases.
- In a laboratory environment, the compressive strength of allograft bone can be determined using the appropriate machinery to subject the bone to a compressive force until failure occurs. Although the compressive strength of a particular specimen of cancerous bone can be determined using this method, this method is impracticable. Firstly, using this method, the particular specimen tested is destroyed. Secondly, the compressive strength of the specimen tested is not determinative of the compressive strength of cancellous bone from a different, or even the same donor.
- As discussed above, cancellous bone allografts are used in a variety of surgical procedures including spinal fusion procedures, e.g., fusion procedures in the cervical region of the spine. In a spinal fusion procedure, at least a portion of the disc between adjacent vertebrae is removed and an allograft is positioned between adjacent vertebral endplates to retain and support the vertebrae at a fixed location with respect to each other. It is imperative to the success of such a procedure that the allograft be capable of withstanding the compressive forces generated by the vertebrae.
- Accordingly, an improved method for determining the strength of allografts formed of cancellous bone is needed which does not destroy the bone and which can be easily and quickly performed by a technician.
- A non-destructive method for evaluating the strength of cancellous bone, includes the steps of performing at least two of the following test on each cancellous bone of a population of cancellous bones, namely, a manual compression test, an apparent density test, and an appearance test; determining a compressive strength for each cancellous bone based on the two tests performed; comparing the determined compressive strength of each cancellous bone against a predetermined compressive strength requirement; and eliminating a subset of cancellous bone from the population of cancellous bone, which subset of cancellous bone fails to meet the predetermined compressive strength requirement.
- The manual compression test includes the steps of manually compressing each cancellous bone to make a subjective determination of the compressive strength of each cancellous bone and removing a cancellous bone from the population of cancellous bones when the manually compressed cancellous bone appreciably deforms. The appearance test includes the steps of assessing a quality of each cancellous bone based on their individual appearance and assigning each cancellous bone with a grade which designates a subjective quality assessment of each cancellous bone. The apparent density test includes the steps of cleaning each cancellous bone, freeze drying each cancellous bone, measuring the dimensions of each cancellous bone to determine a volume thereof, weighing each cancellous bone, determining an apparent density for each cancellous bone, and determining the compressive strength of each cancellous bone based on the apparent density.
- Preferred embodiments of the presently disclosed non-destructive method for evaluating cancellous bone strength of allograft tissue will now be described.
- The presently disclosed non-destructive method for evaluating cancellous bone strength of allograft tissue includes three separate tests which are performed by a technician during preparation of the allograft. These tests include the appearance test, the manual compression test and the apparent density test. Each test is used to determine or identify a subset of cancellous bone allografts which have better strength than those of the overall population of cancellous allografts.
- Initially, a cancellous bone allograft is cut from cancellous bone of a donor into the desired configuration which may be a cylindrical dowel, a wedge, a rectangular spacer, etc. Prior to cutting, the donor bone may be cleaned using an external spray to remove soft tissue from the external surface of the bone. The allograft should be cut such that the first facing cuts (which will become the top or bottom loading surfaces of the allograft) are perpendicular to the trabecular orientation in the bone. Typically, these facing cuts will be perpendicular to the long axis of the bone. In this way, the graft will be loaded in a similar orientation to the loading orientation of the graft during the donor's lifetime as disclosed in the article “Orienting Cancellous Bone For The Preparation of Graftech Cervical Spacer” by Todd Boyce, the entire contents of which is hereby incorporated by reference. After the allograft has been cut into a desired configuration, a technician will perform each of the above-identified tests and evaluations.
- The manual compression test may be performed prior to or after cleaning of the bone but must be performed prior to freeze drying the allograft. In conducting the manual compression test, the cancellous bone allograft is compressed between the technician's fingers to make a subjective determination of the hardness and the compressive strength of the cancellous bone allograft. The manual compression test provides a first level of allograft screening. If the allograft compresses appreciably or deforms greatly between the fingers of a technician, the allograft is discarded. Discarded allograft bone can be used to form other osteoinductive materials or compounds. Using the manual compression test, trained technicians can consistently eliminate grafts which fall below a minimum required compressive strength. The minimum required compressive strength of the graft will vary according to the intended use of the graft, e.g., the minimum required compressive strength of a graft for use in the cervical spine is approximately 500 newtons.
- After the manual compression test has been conducted and the cancellous bone allograft has been cleaned by removing the blood and marrow from the bone, the technician performs the appearance test. In conducting the appearance test, a technician assesses the quality of the allograft based on its appearance to determine if the allograft meets the standard of “dense cancellous bone”. The technician will assign the load bearing allograft a rating using a Grade 1 to Grade 5 scale (1 being the most suitable for allograft use and 5 being the least suitable) to designate the technician's subjective quality assessment of the cancellous bone allograft. The attached description specifying in detail the characteristics of Grade 1-Grade 5 allografts is disclosed in, “Freeze Dried Graftech Cervical Spacer: Implant Visual Grade Characteristics”, the entire contents of which is hereby incorporated by reference. The appearance test can be conducted prior to or after freeze drying the bone.
- Finally, an apparent density test of the cancellous bone allograft will be conducted to estimate the strength of the allograft. More specifically, each allograft is weighed and its dimensions are measured to determine the volume of the allograft (including the volume of the pore spaces). Knowing the weight and volume, the apparent density of the allograft can be easily determined. The apparent density test of each allograft should be conducted after the allograft has been cleaned, the cleaning solution has been removed from the allograft and the allograft has been freeze dried. Alternately, the apparent density test can be conducted prior to freeze drying the allograft. It is noted that if cancellous bone allografts are cut to specific dimensions, each allograft need not be measured independently but rather the volume of the allograft can be determined based on the pre-selected dimensions of the allograft. If the apparent density test is conducted prior to freeze drying, some process should be used to reduce the water content in the allograft bone to a predetermined level such that the volume of water remaining in the cancerous bone can be factored into the apparent density measurement. Using known data gotten through prior testing of a statistically significant number of cancellous bone samples, a graph can be plotted comparing compressive strength of cancellous bone v. apparent density of the cancerous bone. Using this graph, the compressive strength of a cancellous bone graft can be estimated after the apparent density of the graft has been determined. If the allograft has passed the manual compression test, the appearance test and has the required apparent density, the allograft is acceptable for allograft use.
- It will be understood that various modifications may be made to the embodiments disclosed herein. For example, the order of the tests may be varied. Moreover, the degree to which the bone has been cleaned, freeze dried, or prepared before each or all of the tests are conducted may vary, e.g., the cancellous bone need not be cleaned or it may undergo a complete cleaning cycle before conducting any one or all of the above-identified tests. Further, each of these tests may be used individually or in conjunction with any one or both of the remaining tests to eliminate unsuitable bone from consideration as graft bone. For example, the apparent density test may be used alone or in combination with only the manual compression test to identify a subset of cancellous bone allografts which meet or do not meet necessary strength requirements. Therefore, the above description should not be construed as limiting, but merely as exemplifications of preferred embodiments. Those skilled in the art will envision other modifications within the scope and spirit of the claims appended hereto.
Claims (18)
1. A non-destructive method for evaluating the strength of cancellous bone, comprising the steps of:
providing a population of cancellous bone;
performing at least two of the following:
a manual compression test,
an apparent density test, and
an appearance test on each cancellous bone of said population of cancerous bone;
determining a compressive strength for each cancellous bone of said population of cancellous bone based on said at least two tests performed;
comparing said determined compressive strength of each cancellous bone against a predetermined compressive strength requirement; and
eliminating a subset of cancellous bone from said population of cancellous bone, which subset of cancellous bone fails to meet said predetermined compressive strength requirement.
2. The method for evaluating the strength of cancerous bone according to claim 1 , wherein said manual compression test and said apparent density test are performed on each cancellous bone of said population of cancerous bone in order to determine said compressive strength.
3. The method for evaluating the strength of cancellous bone according to claim 1 , wherein said manual compression test and said appearance test are performed on each cancellous bone of said population of cancellous bone in order to determine said compressive strength.
4. The method for evaluating the strength of cancellous bone according to claim 1 , wherein said apparent density test and said appearance test are performed on each cancerous bone of said population of cancellous bone in order to determine said compressive strength.
5. The method for evaluating the strength of cancellous bone according to claim 1 , wherein said manual compression test, said apparent density test and said appearance test are performed on each cancellous bone of said population of cancellous bone in order to determine said compressive strength.
6. The method for evaluating the strength of cancellous bone according to claim 1 , wherein said tests are performed on each of said cancellous bones after each of said cancellous bones have been freeze dried.
7. The method for evaluating the strength of cancellous bone according to claim 1 , wherein said manual compression test includes the steps of a
manually compressing each of said cancellous bones to make a subjective determination of said compressive strength of each of said cancellous bones; and
removing a cancellous bone from said population of cancellous bones when said manually compressed cancellous bone appreciably deforms.
8. The method for evaluating the strength of cancellous bone according to claim 2 , wherein said manual compression test includes the steps of:
manually compressing each of said cancellous bones to make a subjective determination of said compressive strength of each of said cancellous bones; and
removing a cancellous bone from said population of cancellous bones when said manually compressed cancellous bone appreciably deforms.
9. The method for evaluating the strength of cancellous bone according to claim 3 , wherein said manual compression test includes the steps of:
manually compressing each of said cancellous bones to make a subjective determination of said compressive strength of each of said cancellous bones; and
removing a cancellous bone from said population of cancellous bones when said manually compressed cancellous bone appreciably deforms.
10. The method for evaluating the strength of cancellous bone according to claim 5 , wherein said manual compression test includes the steps of:
manually compressing each of said cancellous bones to make a subjective determination of said compressive strength of each of said cancellous bones; and
removing a cancellous bone from said population of cancellous bones when said manually compressed cancellous bone appreciably deforms.
11. The method for evaluating the strength of cancerous bone according to claim 1 , wherein said appearance test includes the steps of:
assessing a quality of each of said cancerous bones based on their individual appearance; and
assigning each of said cancerous bones with a grade which designates a subjective quality assessment of each of said cancerous bones.
12. The method for evaluating the strength of cancerous bone according to claim 3 , wherein said appearance test includes the steps of:
assessing a quality of each of said cancerous bones based on their individual appearance; and
assigning each of said cancerous bones with a grade which designates a subjective quality assessment of each of said cancerous bones.
13. The method for evaluating the strength of cancerous bone according to claim 4 , wherein said appearance test includes the steps of:
assessing a quality of each of said cancerous bones based on their individual appearance; and
assigning each of said cancerous bones with a grade which designates a subjective quality assessment of each of said cancerous bones.
14. The method for evaluating the strength of cancellous bone according to claim 5 , wherein said appearance test includes the steps of:
assessing a quality of each of said cancellous bones based on their individual appearance; and
assigning each of said cancerous bones with a grade which designates a subjective quality assessment of each of said cancellous bones.
15. The method for evaluating the strength of cancellous bone according to claim 1 , wherein said apparent density test includes the steps of:
cleaning each of said cancellous bones;
freeze drying each of said cancellous bones;
measuring the dimensions of each of said cancellous bones;
determining a volume of each of said cancerous bones from said measured dimensions;
weighing each of said cancellous bones;
determining an apparent density for each of said cancellous bones; and
determining said compressive strength of each of said cancellous bones based on said apparent density.
16. The method for evaluating the strength of cancellous bone according to claim 2 , wherein said apparent density test includes the steps of:
cleaning each of said cancellous bones;
freeze drying each of said cancellous bones;
measuring the dimensions of each of said cancellous bones;
determining a volume of each of said cancerous bones from said measured dimensions;
weighing each of said cancerous bones;
determining an apparent density for each of said cancellous bones; and
determining said compressive strength of each of said cancellous bones based on said apparent density.
17. The method for evaluating the strength of cancerous bone according to claim 4 , wherein said apparent density test includes the steps of:
cleaning each of said cancellous bones;
freeze drying each of said cancellous bones;
measuring the dimensions of each of said cancerous bones;
determining a volume of each of said cancellous bones from said measured dimensions;
weighing each of said cancerous bones;
determining an apparent density for each of said cancerous bones; and
determining said compressive strength of each of said cancellous bones based on said apparent density.
18. The method for evaluating the strength of cancellous bone according to claim 5 , wherein said apparent density test includes the steps of:
cleaning each of said cancellous bones;
freeze drying each of said cancellous bones;
measuring the dimensions of each of said cancerous bones;
determining a volume of each of said cancerous bones from said measured dimensions;
weighing each of said cancerous bones;
determining an apparent density for each of said cancerous bones; and
determining said compressive strength of each of said cancerous bones based on said apparent density.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/045,276 US20020100483A1 (en) | 2000-10-25 | 2001-10-25 | Non-destructive method for evaluating cancellous bone strength of allograft tissue |
| US10/884,097 US7448264B2 (en) | 2000-10-25 | 2004-07-02 | Non-destructive method for evaluating the strength of cancellous bone |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24317000P | 2000-10-25 | 2000-10-25 | |
| US10/045,276 US20020100483A1 (en) | 2000-10-25 | 2001-10-25 | Non-destructive method for evaluating cancellous bone strength of allograft tissue |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US10/884,097 Continuation US7448264B2 (en) | 2000-10-25 | 2004-07-02 | Non-destructive method for evaluating the strength of cancellous bone |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| US20020100483A1 true US20020100483A1 (en) | 2002-08-01 |
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US10/045,276 Abandoned US20020100483A1 (en) | 2000-10-25 | 2001-10-25 | Non-destructive method for evaluating cancellous bone strength of allograft tissue |
| US10/884,097 Expired - Lifetime US7448264B2 (en) | 2000-10-25 | 2004-07-02 | Non-destructive method for evaluating the strength of cancellous bone |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US10/884,097 Expired - Lifetime US7448264B2 (en) | 2000-10-25 | 2004-07-02 | Non-destructive method for evaluating the strength of cancellous bone |
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| US (2) | US20020100483A1 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090158339A1 (en) * | 2000-04-03 | 2009-06-18 | Scientific-Atlanta, Inc. | Configurable options for accessible on-demand information |
| CN109444344A (en) * | 2018-12-17 | 2019-03-08 | 中国矿业大学 | The experimental provision and method of joint prosthesis biological fixation interface fine motion stimulation of bone growth |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011063240A1 (en) | 2009-11-20 | 2011-05-26 | Knee Creations, Llc | Implantable devices for subchondral treatment of joint pain |
| US8821504B2 (en) | 2009-11-20 | 2014-09-02 | Zimmer Knee Creations, Inc. | Method for treating joint pain and associated instruments |
| US8951261B2 (en) | 2009-11-20 | 2015-02-10 | Zimmer Knee Creations, Inc. | Subchondral treatment of joint pain |
| KR20120132469A (en) | 2009-11-20 | 2012-12-05 | 니 크리에이션스, 엘엘씨 | Coordinate mapping system for joint treatment |
| KR20120104580A (en) | 2009-11-20 | 2012-09-21 | 니 크리에이션스, 엘엘씨 | Navigation and positioning instruments for joint repair |
| CN102740789A (en) | 2009-11-20 | 2012-10-17 | 膝部创造物有限责任公司 | Instruments for targeting a joint defect |
| WO2011063267A1 (en) | 2009-11-20 | 2011-05-26 | Knee Creations, Llc | Instruments for a variable angle approach to a joint |
| US8801800B2 (en) | 2009-11-20 | 2014-08-12 | Zimmer Knee Creations, Inc. | Bone-derived implantable devices and tool for subchondral treatment of joint pain |
| US9267870B2 (en) * | 2012-01-20 | 2016-02-23 | Allosource | Constant force compression tool |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6442287B1 (en) * | 1998-08-28 | 2002-08-27 | Arch Development Corporation | Method and system for the computerized analysis of bone mass and structure |
| DE60128141T2 (en) * | 2000-10-17 | 2008-01-03 | Maria-Grazia Santa Monica Ascenzi | SYSTEM AND METHOD FOR MODELING BONE STRUCTURES |
| US6761739B2 (en) * | 2002-11-25 | 2004-07-13 | Musculoskeletal Transplant Foundation | Cortical and cancellous allograft spacer |
-
2001
- 2001-10-25 US US10/045,276 patent/US20020100483A1/en not_active Abandoned
-
2004
- 2004-07-02 US US10/884,097 patent/US7448264B2/en not_active Expired - Lifetime
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090158339A1 (en) * | 2000-04-03 | 2009-06-18 | Scientific-Atlanta, Inc. | Configurable options for accessible on-demand information |
| CN109444344A (en) * | 2018-12-17 | 2019-03-08 | 中国矿业大学 | The experimental provision and method of joint prosthesis biological fixation interface fine motion stimulation of bone growth |
Also Published As
| Publication number | Publication date |
|---|---|
| US7448264B2 (en) | 2008-11-11 |
| US20050081619A1 (en) | 2005-04-21 |
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