US10463868B2 - Device for treating a body surface of a living body - Google Patents
Device for treating a body surface of a living body Download PDFInfo
- Publication number
- US10463868B2 US10463868B2 US15/026,033 US201415026033A US10463868B2 US 10463868 B2 US10463868 B2 US 10463868B2 US 201415026033 A US201415026033 A US 201415026033A US 10463868 B2 US10463868 B2 US 10463868B2
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- Prior art keywords
- dielectric
- layer
- body surface
- bumps
- electrode
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/40—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0408—Use-related aspects
- A61N1/0468—Specially adapted for promoting wound healing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/0404—Electrodes for external use
- A61N1/0472—Structure-related aspects
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/44—Applying ionised fluids
-
- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
- H05H1/00—Generating plasma; Handling plasma
- H05H1/24—Generating plasma
- H05H1/2406—Generating plasma using dielectric barrier discharges, i.e. with a dielectric interposed between the electrodes
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- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
- H05H1/00—Generating plasma; Handling plasma
- H05H1/24—Generating plasma
- H05H1/2406—Generating plasma using dielectric barrier discharges, i.e. with a dielectric interposed between the electrodes
- H05H1/2418—Generating plasma using dielectric barrier discharges, i.e. with a dielectric interposed between the electrodes the electrodes being embedded in the dielectric
-
- H05H2001/2418—
-
- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
- H05H2277/00—Applications of particle accelerators
- H05H2277/10—Medical devices
- H05H2277/11—Radiotherapy
Definitions
- the invention relates to a device for treating a body surface of a living body by means of a dielectric barrier discharge plasma, comprising a planar, flexible dielectric, which shields an electrode connected to a high-voltage source from the body surface and which is suitable for placement on the body surface acting as a counter electrode and which is embodied with a structured surface enabling a gas space for the plasma discharge between the dielectric and the body surface.
- the planar flexible dielectric has a larger embodiment in terms of area dimensions than the electrode connected to the high-voltage source such that the dielectric safely shields the electrode in the direction of the body surface, and so a destructive flashover onto the skin surface is reliably avoided.
- the electrode can also be embedded in the dielectric on all sides and merely lead out of the dielectric by means of a connection line.
- the surface of the dielectric pointing to the body surface is structured in such a way that gas spaces are formed between the dielectric and the body surface, in which the plasma discharge can take place.
- the plasma treatment of the body surface may be carried out for cosmetic reasons, for example in order to disinfect the body surface and prepare it for a subsequent treatment with active ingredients, as result of which the uptake of the active ingredients through the skin is improved.
- a plasma treatment of the body surface has proven its worth for promoting wound healing in particular, particularly in the case of chronic wounds.
- the plasma treatment has a strong antimicrobial effect, and so effects as a result of bacterial colonization, which interfere with the wound treatment, can be suppressed by means of the plasma treatment.
- Germs interfering with the wound healing include, in particular, Staphylococcus aureus, Pseudomonas aeruginosa, E. coli and other multi-resistant pathogens.
- the microcirculation in the tissue composite can be positively influenced by the action of the plasma.
- wound dressings are used for the wound treatment, in particular of chronic wounds, which wound dressings, in accordance with the principles of moist wound treatment, have sterile wound pads which are provided with various antiseptic active ingredients for reducing germs. Moreover, the wounds are rinsed in an antiseptic manner. In the case of deep layers, the wounds are additionally cleaned by means of surgical methods. These methods often only lead to an insufficient germ reduction, and so there continue to be risks of infection and risks of the germs spreading. In the case of strong colonization, in particular in the form of a bio-film, and if highly virulent pathogens occur, e.g. group A Streptococcus , the wound healing is delayed or even prevented as a result of infections. Effective methods based on the use of surgical techniques are all invasive, painful and require pain treatment and/or anesthetization.
- the invention is based on the object of specifying a device of the type set forth at the outset, by means of which the treatment of a body surface of a living body is possible in an improved manner.
- a device of the type set forth at the outset is, according to the invention, characterized in that a layer made of a solid, open-pore matrix of a curative or healing material is arranged on the surface of the dielectric.
- the device according to the invention has an open-pore material on the surface of the dielectric, in which the dielectric barrier plasma discharge can form. Therefore, it is possible, firstly, to exploit the advantages of the plasma treatment of the body surface and, secondly, to keep the body surface in contact with the curative or healing material. Therefore, the contact with the curative or healing material need not be forfeited in order to carry out the plasma treatment, as would be required if a plasma treatment and a curative or healing treatment were to be carried out in succession. Particularly in the case of wound dressings, removing the wound dressing for carrying out the plasma treatment would be very bothersome in some circumstances.
- the device according to the invention enables the combined treatment of the body surface in the form of a plasma treatment, which is preferably carried out a number of times, and a treatment with a curative or healing material.
- the layer made of the curative or healing material can be embodied as a separate layer with a surface that is complementary to the structured surface of the dielectric. This is advantageous because this avoids the creation of air gaps, and so there is a uniform plasma formation within the layer.
- the layer is preferably embodied in such a way that it is bendable with the dielectric. In this way, the advantage of the flexible electrode arrangement, which can be placed with the dielectric on irregularly formed body parts as well, is maintained.
- the structuring of the surface of the dielectric also can be formed from protruding bumps for the device according to the invention.
- the bumps preferably have a free planar end side for placement on the body surface.
- the layer consists of material that is resorbable by the body.
- the layer consists of collagen in a preferred embodiment such that the layer is resorbed by the body over a period of the order of a few days.
- certain layers made of healing or curative material can also be grown onto a plastic carrier, as a result of which the layer is immediately securely connected to the plastic carrier.
- the layer need not be produced as a separate layer in this case; instead, it can grow onto the structured surface of the dielectric. This is advantageous, particularly for a collagen layer.
- the grown layer automatically is formed in a manner complementary to the structuring of the surface of the dielectric.
- the combination, according to the invention, of the device for the plasma treatment with a structured dielectric surface and the application of a layer of healing or curative material which, in particular, is completely resorbable by the body opens up numerous advantageous treatment options in the field of cosmetics and, in particular, medicine. Significant successes can be obtained in the healing of wounds which otherwise heal badly or not all, particularly in combination with a collagen layer.
- FIG. 1 shows a schematic illustration of a device comprising a dielectric with a structured surface and a separately created layer, the surface of which is embodied in a manner complementary to the surface of the dielectric;
- FIG. 2 shows the arrangement from FIG. 1 in the assembled state suitable for the application.
- the electrode is embedded in a planar dielectric 4 and therefore completely shielded from the surroundings.
- the planar dielectric therefore has narrow sides 5 and large side surfaces in the form of a rear side 6 and a treatment side 7 opposite thereto.
- On the treatment side 7 there are bumps 8 projecting from the cuboid body of the dielectric 4 , which bumps have a cylindrical embodiment in the depicted exemplary embodiment but can also have any other form.
- the bumps 8 preferably have a cylindrical embodiment and the same height such that free, planar end sides 9 are able to form a common resting surface on a body surface to be treated.
- an interspace 10 level with the bumps 8 is formed between the bumps when the electrode arrangement is placed by means of the end faces 9 of the bumps on a body surface to be treated.
- a layer 11 formed from an open-pore matrix made of a curative or healing material interacts with the electrode arrangement known to this extent from DE 10 2009 060 627 A1.
- a layer which, as a carrier layer, is doped with curative or healing substances is also understood to be a curative or healing material.
- the layer has an embodiment that is complementary to the surface of the electrode arrangement facing the body surface. Accordingly, the layer 11 fills the interspace 10 between the bumps 8 and has openings 12 which are complementary to the bumps 8 such that the layer 11 completes the dielectric 4 to form a planar electrode arrangement with a smooth contact side 13 for placement on the body surface in the assembled state, as is depicted in FIG. 2 .
- the thickness of the layer 11 corresponds to the length of the bumps 8 .
- the layer 11 consists of a material that is completely resorbable by the body.
- the layer disappears over the course of the application and the electrode arrangement, depicted separately in FIG. 1 , remains on the body surface without the layer 11 .
- the end sides 9 of the bumps 8 are flush with the contact side 13 ; i.e., they already rest against the body surface when the layer 11 still is present in its entirety. Therefore, the position of the electrode arrangement does not change when material of the layer 11 is resorbed by the body.
- the layer 11 it is also possible for the layer 11 to have a thicker embodiment than the length of the bumps 8 such that the layer 11 has corresponding cylindrical blind holes as openings 12 in the case of cylindrical bumps 8 .
- This is particularly unproblematic if the material of the layer is not resorbed but only contains curative or healing constituents which migrate into the body surface. If the layer 11 consists of resorbable material, the distance between the dielectric 4 and the body surface will reduce when the layer 11 disappears as a result of resorption. Hence, in this case, it is necessary to ensure that the electrode arrangement is fastened to the body surface under a certain amount of pre-tension such that the dielectric 4 can follow in the direction of the body surface when the layer 11 is resorbed.
- the material of the layer 11 is preferably a solid collagen matrix, which promotes wound healing and which is completely resorbable.
- the production of such a matrix is described in EP 2 322 232 A2, with reference being made thereto.
- the dielectric 4 is preferably a castable plastic such that the bumps 8 can be formed in an integral manner onto the dielectric 4 .
- the bumps 8 it is also conceivable for the bumps 8 to be manufactured separately and connected to the dielectric 4 . In this case, the bumps 8 can form a cohesive part of the dielectric 4 and can be connected with a counterpart to form the dielectric 4 .
- the electrode 1 is inserted between the two parts of the dielectric 4 in the case of such a two-part design.
- Completely embedding the electrode 1 in the dielectric 4 is advantageous and, in particular, also allows the integral embodiment of the dielectric 4 with the bumps 8 .
- use cases in which the dielectric 4 merely brings about the shielding of the electrode 1 in the direction of the treatment side 7 such that a flashover from the electrode 1 to the body surface is suppressed with certainty are also conceivable.
- Covering the electrode 1 toward the rear side 6 can optionally be dispensed with or insulation can be brought about in a different manner.
- the illustrated bumps 8 are only one conceivable embodiment of the structuring of the treatment side 7 of the dielectric 4 .
- Any type of structuring for example in the form of parallel grooves, grid-shaped notches or the like, is possible in order to form an interspace 10 which is required for the plasma discharge.
- the layer 11 which has a complimentary embodiment to the surface of the dielectric 4 and which completely fills the interspace 10 forms channels between the dielectric 4 and the body surface due to the open pore property thereof, in which channels the dielectric barrier plasma discharge takes place between the electrode 1 and the body surface as a counter electrode. Hence, the plasma discharge is performed within the channels present in the material of the layer 11 .
- the structuring of the treatment side 7 of the dielectric need not follow a regular pattern either. All that is important is a statistically uniform distribution of the interspace 10 over the active surface on the treatment side 7 such that there is a uniform plasma formation over the treatment area.
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- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Radiology & Medical Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physics & Mathematics (AREA)
- Plasma & Fusion (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Electrotherapy Devices (AREA)
- Plasma Technology (AREA)
- Materials For Medical Uses (AREA)
Abstract
Description
Claims (10)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102013019057.6 | 2013-11-15 | ||
DE102013019057 | 2013-11-15 | ||
DE102013019057.6A DE102013019057B4 (en) | 2013-11-15 | 2013-11-15 | Apparatus for treating a body surface of a living body |
PCT/DE2014/000572 WO2015070832A1 (en) | 2013-11-15 | 2014-11-06 | Device for treating a body surface of a living body |
Publications (2)
Publication Number | Publication Date |
---|---|
US20160236002A1 US20160236002A1 (en) | 2016-08-18 |
US10463868B2 true US10463868B2 (en) | 2019-11-05 |
Family
ID=52130033
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US15/026,033 Active 2036-12-15 US10463868B2 (en) | 2013-11-15 | 2014-11-06 | Device for treating a body surface of a living body |
Country Status (7)
Country | Link |
---|---|
US (1) | US10463868B2 (en) |
EP (1) | EP3069578B1 (en) |
JP (1) | JP6509892B2 (en) |
CN (1) | CN105722552B (en) |
DE (1) | DE102013019057B4 (en) |
ES (1) | ES2699876T3 (en) |
WO (1) | WO2015070832A1 (en) |
Families Citing this family (22)
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MX2017014581A (en) | 2015-05-15 | 2018-03-09 | Clearit Llc | Systems and methods for tattoo removal using cold plasma. |
US11490947B2 (en) | 2015-05-15 | 2022-11-08 | Clear Intradermal Technologies, Inc. | Tattoo removal using a liquid-gas mixture with plasma gas bubbles |
DE102015111401B3 (en) * | 2015-07-14 | 2016-09-01 | Cinogy Gmbh | Treatment device for treatment with a dielectrically impeded plasma |
DE102015117715A1 (en) * | 2015-10-19 | 2017-04-20 | Cinogy Gmbh | Electrode arrangement for a dielectrically impeded plasma treatment |
DE102016108450B4 (en) | 2016-05-06 | 2020-01-02 | Cinogy Gmbh | Treatment arrangement and method for producing a treatment arrangement |
US10765850B2 (en) | 2016-05-12 | 2020-09-08 | Gojo Industries, Inc. | Methods and systems for trans-tissue substance delivery using plasmaporation |
TWI574711B (en) * | 2016-05-18 | 2017-03-21 | Sg Biomedical Co Ltd | Skin repair device |
WO2018089577A1 (en) | 2016-11-10 | 2018-05-17 | EP Technologies LLC | Methods and systems for generating plasma activated liquid |
NL2017822B1 (en) * | 2016-11-18 | 2018-05-25 | Plasmacure B V | Non-Thermal Plasma Device with electromagnetic compatibility control |
DE102017100192A1 (en) * | 2017-01-06 | 2018-07-12 | Cinogy Gmbh | Permanent wound dressing with plasma electrode |
DE102017111902B4 (en) * | 2017-05-31 | 2020-12-31 | Cinogy Gmbh | Flat support arrangement |
DE102017116305A1 (en) | 2017-07-19 | 2019-01-24 | Cinogy Gmbh | Plasma treatment device |
DE102017116800B4 (en) | 2017-07-25 | 2024-03-14 | Cinogy Gmbh | Electrode arrangement for a dielectrically hindered plasma treatment |
US11690998B2 (en) * | 2017-10-31 | 2023-07-04 | Theradep Technologies, Inc. | Methods of treating bacterial infections |
CN107949137A (en) * | 2017-11-02 | 2018-04-20 | 大连民族大学 | A kind of self-adapting flexible plasma discharging body device |
KR101970644B1 (en) * | 2017-11-22 | 2019-08-13 | 주식회사 하이로닉 | Multifunctional skin treatment device for enhancement of transdermal delivery |
US11219118B2 (en) | 2018-02-20 | 2022-01-04 | Drexel University | Method of generation of planar plasma jets |
CN108322990A (en) * | 2018-02-24 | 2018-07-24 | 北京睿昱达科技有限公司 | A kind of plasma generating assembly and air cleaning unit |
DE202018005328U1 (en) | 2018-11-14 | 2018-12-12 | Gesellschaft zur Förderung von Medizin-, Bio- und Umwelttechnologien e.V. | LED radiation device for the prevention of wound infections and for the healing of wounds and wound infections |
CN113329707A (en) | 2018-12-19 | 2021-08-31 | 克利里特有限责任公司 | System and method for tattoo removal using an applied electric field |
DE102019130213A1 (en) * | 2019-11-08 | 2021-05-12 | Relyon Plasma Gmbh | Discharge system and method for generating a dielectric barrier discharge |
CN111988902B (en) * | 2020-08-14 | 2022-08-05 | 清华大学 | Flexible gasbag formula plasma generator |
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2013
- 2013-11-15 DE DE102013019057.6A patent/DE102013019057B4/en not_active Expired - Fee Related
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2014
- 2014-11-06 JP JP2016553705A patent/JP6509892B2/en active Active
- 2014-11-06 US US15/026,033 patent/US10463868B2/en active Active
- 2014-11-06 EP EP14815218.4A patent/EP3069578B1/en active Active
- 2014-11-06 WO PCT/DE2014/000572 patent/WO2015070832A1/en active Application Filing
- 2014-11-06 ES ES14815218T patent/ES2699876T3/en active Active
- 2014-11-06 CN CN201480062299.1A patent/CN105722552B/en active Active
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US20150094647A1 (en) * | 2013-09-27 | 2015-04-02 | EP Technologies LLC | Methods and apparatus for delivery of molecules across layers of tissue |
US20160089545A1 (en) * | 2013-09-27 | 2016-03-31 | EP Technologies LLC | Methods and apparatus for delivery of molecules across layers of tissue |
US20180295708A1 (en) * | 2015-10-19 | 2018-10-11 | Cinogy Gmbh | Electrode Array for a Dielectrically Impeded Plasma Treatment |
US20170326347A1 (en) * | 2016-05-12 | 2017-11-16 | EP Technologies LLC | Methods and systems for trans-tissue substance delivery using plasmaporation |
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JP2017503621A (en) | 2017-02-02 |
DE102013019057A1 (en) | 2015-05-21 |
CN105722552B (en) | 2018-02-06 |
EP3069578B1 (en) | 2018-10-24 |
CN105722552A (en) | 2016-06-29 |
DE102013019057B4 (en) | 2018-02-15 |
ES2699876T3 (en) | 2019-02-13 |
JP6509892B2 (en) | 2019-05-08 |
EP3069578A1 (en) | 2016-09-21 |
WO2015070832A1 (en) | 2015-05-21 |
US20160236002A1 (en) | 2016-08-18 |
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