UA99452C2 - Способ стимулирования миелинизации и дифференцирования олигодендроцитов путем применения семафорина 6a - Google Patents

Способ стимулирования миелинизации и дифференцирования олигодендроцитов путем применения семафорина 6a

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Publication number
UA99452C2
UA99452C2 UAA200908176A UAA200908176A UA99452C2 UA 99452 C2 UA99452 C2 UA 99452C2 UA A200908176 A UAA200908176 A UA A200908176A UA A200908176 A UAA200908176 A UA A200908176A UA 99452 C2 UA99452 C2 UA 99452C2
Authority
UA
Ukraine
Prior art keywords
semaphorin
oligodendrocyte differentiation
promoting myelination
demyelination
myelination
Prior art date
Application number
UAA200908176A
Other languages
English (en)
Ukrainian (uk)
Inventor
Ален Шедоталь
Ша Ми
Фредерик Бернар
Original Assignee
Байоджэн Айдэк Ма Инк.
Сантр Насьональ Де Ля Решерш Сьентифик
Юнивесити Пьер Энд Мари Кюри
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Байоджэн Айдэк Ма Инк., Сантр Насьональ Де Ля Решерш Сьентифик, Юнивесити Пьер Энд Мари Кюри filed Critical Байоджэн Айдэк Ма Инк.
Publication of UA99452C2 publication Critical patent/UA99452C2/ru

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  • Health & Medical Sciences (AREA)
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Abstract

Изобретение относится к способам лечения заболеваний, расстройств или повреждений, при которых наблюдается демиелинизация и дисмиелинизация, в том числе рассеянного склероза, путем применения полипептида Sema6A.
UAA200908176A 2007-02-02 2008-02-04 Способ стимулирования миелинизации и дифференцирования олигодендроцитов путем применения семафорина 6a UA99452C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US89899207P 2007-02-02 2007-02-02

Publications (1)

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UA99452C2 true UA99452C2 (ru) 2012-08-27

Family

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UAA200908176A UA99452C2 (ru) 2007-02-02 2008-02-04 Способ стимулирования миелинизации и дифференцирования олигодендроцитов путем применения семафорина 6a

Country Status (17)

Country Link
US (1) US9107884B2 (ru)
EP (1) EP2114433B1 (ru)
JP (1) JP5492567B2 (ru)
KR (1) KR20090123873A (ru)
CN (1) CN101631559A (ru)
AU (1) AU2008214337B2 (ru)
BR (1) BRPI0806849A2 (ru)
CA (1) CA2677228C (ru)
EA (1) EA017403B1 (ru)
GE (1) GEP20135853B (ru)
IL (1) IL200123A (ru)
MX (1) MX2009008178A (ru)
NZ (1) NZ578816A (ru)
SG (1) SG178744A1 (ru)
UA (1) UA99452C2 (ru)
WO (1) WO2008097503A2 (ru)
ZA (1) ZA200905379B (ru)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8871205B2 (en) * 2009-11-25 2014-10-28 The University Of North Carolina At Chapel Hill Methods and compositions for the treatment of immune disorders
US8986670B2 (en) * 2012-02-29 2015-03-24 Baxter International Inc. IgG stimulated remyelination of peripheral nerves
BR112017009497A2 (pt) 2014-11-05 2018-02-06 Voyager Therapeutics, Inc. polinucleotídeos de aadc para o tratamento da doença de parkinson
BR112017010087A2 (pt) 2014-11-14 2018-06-05 Voyager Therapeutics, Inc. composições e métodos para tratar esclerose lateral amiotrófica (ela)
KR20230145206A (ko) 2014-11-14 2023-10-17 보이저 테라퓨틱스, 인크. 조절성 폴리뉴클레오티드
JP6959869B2 (ja) * 2015-02-23 2021-11-05 シーガル セラピューティクス エスアーエス 非天然セマフォリン３およびそれらの医学的使用
JP6924708B2 (ja) * 2015-06-29 2021-08-25 ザ・ユニバーシティ・オブ・ブリティッシュ・コロンビア Ｂ１ｓｐ融合タンパク質の治療薬、方法、および使用
MX2018014154A (es) 2016-05-18 2019-05-06 Voyager Therapeutics Inc Polinucleotidos moduladores.
JP7109040B2 (ja) * 2016-07-25 2022-07-29 国立大学法人金沢大学 線維化抑制剤
AU2018261790A1 (en) 2017-05-05 2019-11-28 Voyager Therapeutics, Inc. Compositions and methods of treating amyotrophic lateral sclerosis (ALS)
JOP20190269A1 (ar) 2017-06-15 2019-11-20 Voyager Therapeutics Inc بولي نوكليوتيدات aadc لعلاج مرض باركنسون
CN109536506B (zh) * 2018-12-10 2022-03-22 潍坊科技学院 一种调控日本沼虾生长发育的类胰岛素受体基因及其应用

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773319A (en) 1971-12-16 1973-11-20 Fabcor Ind Inc Corrugated sheet inverting machine
US4399216A (en) 1980-02-25 1983-08-16 The Trustees Of Columbia University Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4634665A (en) 1980-02-25 1987-01-06 The Trustees Of Columbia University In The City Of New York Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US5179017A (en) 1980-02-25 1993-01-12 The Trustees Of Columbia University In The City Of New York Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
IE52535B1 (en) 1981-02-16 1987-12-09 Ici Plc Continuous release pharmaceutical compositions
US4510245A (en) 1982-11-18 1985-04-09 Chiron Corporation Adenovirus promoter system
HUT35524A (en) 1983-08-02 1985-07-29 Hoechst Ag Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance
EP0154316B1 (en) 1984-03-06 1989-09-13 Takeda Chemical Industries, Ltd. Chemically modified lymphokine and production thereof
US5168062A (en) 1985-01-30 1992-12-01 University Of Iowa Research Foundation Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence
JP2532858B2 (ja) 1985-04-01 1996-09-11 セルテツク リミテツド 形質転換したミエロ―マ細胞系
US4968615A (en) 1985-12-18 1990-11-06 Ciba-Geigy Corporation Deoxyribonucleic acid segment from a virus
GB8601597D0 (en) 1986-01-23 1986-02-26 Wilson R H Nucleotide sequences
ATE195022T1 (de) 1987-04-27 2000-08-15 Unilever Nv Spezifische bindungstestverfahren
GB8717430D0 (en) 1987-07-23 1987-08-26 Celltech Ltd Recombinant dna product
US5336603A (en) 1987-10-02 1994-08-09 Genentech, Inc. CD4 adheson variants
GB8809129D0 (en) 1988-04-18 1988-05-18 Celltech Ltd Recombinant dna methods vectors and host cells
DE68921982T4 (de) 1988-06-14 1996-04-25 Cetus Oncology Corp Kupplungsmittel und sterisch gehinderte, mit disulfid gebundene konjugate daraus.
CA2006596C (en) 1988-12-22 2000-09-05 Rika Ishikawa Chemically-modified g-csf
US5225538A (en) 1989-02-23 1993-07-06 Genentech, Inc. Lymphocyte homing receptor/immunoglobulin fusion proteins
IE63847B1 (en) 1989-05-05 1995-06-14 Res Dev Foundation A novel antibody delivery system for biological response modifiers
US5314995A (en) 1990-01-22 1994-05-24 Oncogen Therapeutic interleukin-2-antibody based fusion proteins
WO1991014438A1 (en) 1990-03-20 1991-10-03 The Trustees Of Columbia University In The City Of New York Chimeric antibodies with receptor binding ligands in place of their constant region
US5219837A (en) 1990-06-21 1993-06-15 Trustees Of The University Of Pennsylvania Method of stimulating myelination of cells
GB9014932D0 (en) 1990-07-05 1990-08-22 Celltech Ltd Recombinant dna product and method
JPH09506761A (ja) 1990-11-09 1997-07-08 ステファン ディー．ギリーズ サイトカインの免疫複合体
US5252714A (en) 1990-11-28 1993-10-12 The University Of Alabama In Huntsville Preparation and use of polyethylene glycol propionaldehyde
WO1994004679A1 (en) 1991-06-14 1994-03-03 Genentech, Inc. Method for making humanized antibodies
JPH05244982A (ja) 1991-12-06 1993-09-24 Sumitomo Chem Co Ltd 擬人化ｂ−ｂ１０
DE669986T1 (de) 1992-11-13 1996-10-10 Idec Pharma Corp Völlig unfunktionelle konsensus-kozak-sequenzen zur säugetier-exprimierung.
US6068829A (en) 1995-09-11 2000-05-30 The Burnham Institute Method of identifying molecules that home to a selected organ in vivo
CN1175111C (zh) 1997-03-14 2004-11-10 艾德药品公司 将基因整合至哺乳动物细胞特定位点的方法及所用载体
EP1365018A1 (en) 2002-05-23 2003-11-26 Institut National De La Sante Et De La Recherche Medicale (Inserm) CD100 semaphorin in myelination
JP2005528434A (ja) * 2002-05-30 2005-09-22 キュラジェン コーポレイション セマフォリン様タンパク質およびその使用方法

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KR20090123873A (ko) 2009-12-02
AU2008214337B2 (en) 2012-07-05
IL200123A (en) 2013-05-30
US9107884B2 (en) 2015-08-18
US20100189713A1 (en) 2010-07-29
WO2008097503A2 (en) 2008-08-14
EA200901067A1 (ru) 2010-02-26
BRPI0806849A2 (pt) 2015-06-23
SG178744A1 (en) 2012-03-29
CN101631559A (zh) 2010-01-20
EP2114433B1 (en) 2014-04-09
WO2008097503A8 (en) 2009-11-05
CA2677228A1 (en) 2008-08-14
GEP20135853B (en) 2013-06-25
EP2114433A2 (en) 2009-11-11
JP2010518007A (ja) 2010-05-27
CA2677228C (en) 2015-12-08
WO2008097503A3 (en) 2008-12-24
JP5492567B2 (ja) 2014-05-14
AU2008214337A1 (en) 2008-08-14
MX2009008178A (es) 2009-10-26
NZ578816A (en) 2012-06-29
ZA200905379B (en) 2014-01-29
EA017403B1 (ru) 2012-12-28
IL200123A0 (en) 2010-04-15

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