UA98946C2 - Phosphoinositide 3-kinase inhibitor compounds and methods of use - Google Patents

Phosphoinositide 3-kinase inhibitor compounds and methods of use

Info

Publication number
UA98946C2
UA98946C2 UAA200907051A UAA200907051A UA98946C2 UA 98946 C2 UA98946 C2 UA 98946C2 UA A200907051 A UAA200907051 A UA A200907051A UA A200907051 A UAA200907051 A UA A200907051A UA 98946 C2 UA98946 C2 UA 98946C2
Authority
UA
Ukraine
Prior art keywords
methods
compounds
phosphoinositide
kinase inhibitor
inhibitor compounds
Prior art date
Application number
UAA200907051A
Other languages
Russian (ru)
Ukrainian (uk)
Inventor
Трейси БЕЙЛИСС
Ирина Чукори
Адриан ФОУЛКС
Салли ОКСЕНФОРД
Нань Чи ВАНЬ
Жоржетт КАСТАНЕДО
Ричард ГОЛДСМИТ
Дженет ГАНЗНЕР
Тим ХЕФФРОН
Симон МАТЬЕ
Алан ОЛИВЕРО
Стивен СТЕЙБЕН
Дениел П. Сатерлин
Бин-Янь ЧЖУ
Original Assignee
Ф. Хоффманн-Ля Рош Аг
Дженентек, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ф. Хоффманн-Ля Рош Аг, Дженентек, Инк. filed Critical Ф. Хоффманн-Ля Рош Аг
Publication of UA98946C2 publication Critical patent/UA98946C2/en

Links

Abstract

Compounds of Formulas Ia-d where X is S or O, mor is a morpholine group, and R3 is a monocyclic heteroaryl group, and including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for modulating the activity of lipid kinases including PI3K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formula Ia-d for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed., Ic, Id
UAA200907051A 2006-12-07 2007-12-05 Phosphoinositide 3-kinase inhibitor compounds and methods of use UA98946C2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US87344806P 2006-12-07 2006-12-07

Publications (1)

Publication Number Publication Date
UA98946C2 true UA98946C2 (en) 2012-07-10

Family

ID=41421545

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200907051A UA98946C2 (en) 2006-12-07 2007-12-05 Phosphoinositide 3-kinase inhibitor compounds and methods of use

Country Status (3)

Country Link
CN (1) CN101600720A (en)
UA (1) UA98946C2 (en)
ZA (1) ZA200904534B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102010049595A1 (en) * 2010-10-26 2012-04-26 Merck Patent Gmbh quinazoline derivatives
BR112015007970A8 (en) * 2012-10-10 2019-08-27 Hoffmann La Roche process of preparing -1- (4 - ((2- (2-aminopyrimidin-5-yl) -7-methyl-4-morpholinothieno [3,2-d] pyrimidin-6-yl) methyl) piperazin -1-yl) -2-hydroxypropan-1-one and (s) -2-hydroxy-1- (piperazin-1-yl) propan-1-one oxalate salt
CN111675692A (en) * 2020-06-08 2020-09-18 浙江科技学院 Synthetic method of ozenoxacin
WO2022152229A1 (en) * 2021-01-15 2022-07-21 深圳微芯生物科技股份有限公司 Class of morpholine derivatives, preparation method therefor and application thereof
CN113754680B (en) * 2021-09-28 2022-07-22 云白药征武科技(上海)有限公司 Alpha fluoroacyl piperazine derivative and preparation and application thereof

Also Published As

Publication number Publication date
CN101600720A (en) 2009-12-09
ZA200904534B (en) 2010-09-29

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