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Application filed by Такеда Фармасьютикал Компани ЛимитедfiledCriticalТакеда Фармасьютикал Компани Лимитед
Priority claimed from PCT/JP2007/074617external-prioritypatent/WO2008075762A1/en
Publication of UA97125C2publicationCriticalpatent/UA97125C2/en
Medicines That Contain Protein Lipid Enzymes And Other Medicines
(AREA)
Abstract
Sustained-release compositions wherein a water-soluble physiologically active peptide is substantially uniformly dispersed in a microcapsule comprised of a lactic acid polymer or a salt thereof, and the physiologically active substance is contained in an amount of 15 to 35 wt/wt% to the total microcapsules and weight-average molecular weight (Mw) of the lactic acid polymer is about 11,000 to about 27,000, which is characterized by having a high content of the physiologically active substance, and suppression of the initial excessive release within one day after the administration and a stable drag sustained-release over a long period of time, and method for producing the same.
UAA200906304A2006-12-182007-12-17Sustained-release composition and method for producing the same
UA97125C2
(en)