UA94246C2 - Производные индазола, которые ингибируют рецептор trpv1 - Google Patents
Производные индазола, которые ингибируют рецептор trpv1Info
- Publication number
- UA94246C2 UA94246C2 UAA200807267A UAA200807267A UA94246C2 UA 94246 C2 UA94246 C2 UA 94246C2 UA A200807267 A UAA200807267 A UA A200807267A UA A200807267 A UAA200807267 A UA A200807267A UA 94246 C2 UA94246 C2 UA 94246C2
- Authority
- UA
- Ukraine
- Prior art keywords
- indazole derivatives
- trpvl receptor
- inhibit
- inhibit trpvl
- receptor
- Prior art date
Links
- BAXOFTOLAUCFNW-UHFFFAOYSA-N 1H-indazole Chemical class C1=CC=C2C=NNC2=C1 BAXOFTOLAUCFNW-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000035475 disorder Diseases 0.000 abstract 2
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 206010037211 Psychomotor hyperactivity Diseases 0.000 abstract 1
- 102000003566 TRPV1 Human genes 0.000 abstract 1
- 101150016206 Trpv1 gene Proteins 0.000 abstract 1
- 206010046543 Urinary incontinence Diseases 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6503—Five-membered rings
- C07F9/65031—Five-membered rings having the nitrogen atoms in the positions 1 and 2
- C07F9/65038—Five-membered rings having the nitrogen atoms in the positions 1 and 2 condensed with carbocyclic rings or carbocyclic ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Соединения формулы (I),где A, R, Rи Rимеют значения, указанные в описании,которые пригодны как терапевтические соединения, в частности, для лечения нарушений или состояний, связанных с воспалением, болью, повышенной активностью мочевого пузыря, недержанием мочи и других нарушений, вызванных или обостренных TRPV1.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US73099105P | 2005-10-28 | 2005-10-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
UA94246C2 true UA94246C2 (ru) | 2011-04-26 |
Family
ID=37668287
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UAA200807267A UA94246C2 (ru) | 2005-10-28 | 2006-10-27 | Производные индазола, которые ингибируют рецептор trpv1 |
Country Status (15)
Country | Link |
---|---|
US (2) | US8232309B2 (ru) |
EP (1) | EP1957464A1 (ru) |
JP (1) | JP2009513659A (ru) |
KR (1) | KR20080067361A (ru) |
CN (2) | CN102516176A (ru) |
AU (1) | AU2006306146A1 (ru) |
BR (1) | BRPI0617884A2 (ru) |
CA (1) | CA2626593A1 (ru) |
IL (1) | IL190899A0 (ru) |
NZ (1) | NZ567358A (ru) |
RU (1) | RU2008121205A (ru) |
TW (1) | TW200819441A (ru) |
UA (1) | UA94246C2 (ru) |
WO (1) | WO2007050732A1 (ru) |
ZA (1) | ZA200803674B (ru) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7015233B2 (en) * | 2003-06-12 | 2006-03-21 | Abbott Laboratories | Fused compounds that inhibit vanilloid subtype 1 (VR1) receptor |
CN102161653A (zh) | 2004-11-24 | 2011-08-24 | 雅培制药有限公司 | 抑制香草素受体亚型1(vr1)受体的苯并二氢吡喃基脲化合物及其用途 |
JP2008542494A (ja) | 2005-06-01 | 2008-11-27 | イッサム リサーチ ディベロップメント カンパニー オブ ザ ヘブリュー ユニバーシティー オブ エルサレム | 所定のキラリティーを有する生分解性ポリマー |
MX2008013428A (es) | 2006-04-18 | 2008-11-04 | Abbott Lab | Antagonistas del receptor de vanilloides del subtipo (vr1) y usos de los mismos. |
CN101925575B (zh) | 2008-01-28 | 2014-06-18 | 株式会社爱茉莉太平洋 | 作为香草酸受体拮抗剂的化合物、其异构体或其药物学可接受的盐、及包含这些化合物的药物组合物 |
EP2307394B1 (en) | 2008-07-02 | 2012-09-26 | Amorepacific Corporation | Sulphonamides as vanilloid receptor antagonist |
EP2352726A1 (en) * | 2008-10-17 | 2011-08-10 | Abbott Laboratories | Trpv1 antagonists |
JP2012505908A (ja) * | 2008-10-17 | 2012-03-08 | アボット・ラボラトリーズ | Trpv1アンタゴニスト |
US8349852B2 (en) | 2009-01-13 | 2013-01-08 | Novartis Ag | Quinazolinone derivatives useful as vanilloid antagonists |
AU2010289143A1 (en) | 2009-08-24 | 2012-02-16 | Ascepion Pharmaceuticals, Inc. | 5,6-bicyclic heteroaryl-containing urea compounds as kinase inhibitors |
EP2531510B1 (en) | 2010-02-01 | 2014-07-23 | Novartis AG | Pyrazolo[5,1b]oxazole derivatives as crf-1 receptor antagonists |
WO2011092293A2 (en) | 2010-02-01 | 2011-08-04 | Novartis Ag | Cyclohexyl amide derivatives as crf receptor antagonists |
ES2527849T3 (es) | 2010-02-02 | 2015-01-30 | Novartis Ag | Derivados de ciclohexilamida como antagonistas del receptor de CRF |
WO2012031383A1 (zh) * | 2010-09-06 | 2012-03-15 | 中国科学院广州生物医药与健康研究院 | 酰胺类化合物 |
EP3970723A1 (en) * | 2011-02-18 | 2022-03-23 | Asana BioSciences, LLC | Aminoindane compounds for use in treating urological pain |
TW201302681A (zh) | 2011-03-25 | 2013-01-16 | Abbott Lab | Trpv1拮抗劑 |
WO2013096223A1 (en) | 2011-12-19 | 2013-06-27 | Abbvie Inc. | Trpv1 antagonists |
WO2013096226A1 (en) | 2011-12-19 | 2013-06-27 | Abbvie Inc. | Trpv1 antagonists |
BR112014027644A2 (pt) * | 2012-05-09 | 2017-06-27 | Bayer Cropscience Ag | 5-halogenopirazol-indanil-carboxamidas |
US8796328B2 (en) | 2012-06-20 | 2014-08-05 | Abbvie Inc. | TRPV1 antagonists |
JP2016512831A (ja) | 2013-03-15 | 2016-05-09 | コンサート ファーマシューティカルズ インコーポレイテッド | 重水素化されたパルボシクリブ |
WO2014193696A2 (en) * | 2013-05-28 | 2014-12-04 | Transtech Pharma, Llc | Benzimidazole carboxylic acid derivatives, compositions, and methods of use as aurora kinase inhibitors |
WO2015009889A1 (en) | 2013-07-18 | 2015-01-22 | Concert Pharmaceuticals, Inc. | Deuterated intedanib derivatives and their use for the treatment of proliferative disorders |
US9783527B2 (en) * | 2014-09-16 | 2017-10-10 | Abbvie Inc. | Indazole ureas and method of use |
MX370984B (es) | 2015-07-06 | 2020-01-09 | Gilead Sciences Inc | Moduladores de cáncer de tiroides de osaka (cot) y métodos de uso de los mismos. |
TWI770527B (zh) | 2019-06-14 | 2022-07-11 | 美商基利科學股份有限公司 | Cot 調節劑及其使用方法 |
CN115397824A (zh) | 2020-04-02 | 2022-11-25 | 吉利德科学公司 | 用于制备cot抑制剂化合物的方法 |
CN113292485B (zh) * | 2021-06-08 | 2023-10-27 | 河南大学 | 苄基哌嗪脲类trpv1拮抗和mor激动双靶点药物及制备方法和应用 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7015233B2 (en) * | 2003-06-12 | 2006-03-21 | Abbott Laboratories | Fused compounds that inhibit vanilloid subtype 1 (VR1) receptor |
US7375126B2 (en) * | 2003-06-12 | 2008-05-20 | Abbott Laboratories | Fused compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor |
NZ578264A (en) * | 2003-06-12 | 2011-02-25 | Abbott Lab | Fused compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor |
CN102161653A (zh) * | 2004-11-24 | 2011-08-24 | 雅培制药有限公司 | 抑制香草素受体亚型1(vr1)受体的苯并二氢吡喃基脲化合物及其用途 |
-
2006
- 2006-10-27 RU RU2008121205/04A patent/RU2008121205A/ru not_active Application Discontinuation
- 2006-10-27 US US11/588,713 patent/US8232309B2/en active Active
- 2006-10-27 CA CA002626593A patent/CA2626593A1/en not_active Abandoned
- 2006-10-27 NZ NZ567358A patent/NZ567358A/en unknown
- 2006-10-27 CN CN2011103095137A patent/CN102516176A/zh active Pending
- 2006-10-27 CN CNA2006800500913A patent/CN101365684A/zh active Pending
- 2006-10-27 BR BRPI0617884-7A patent/BRPI0617884A2/pt not_active IP Right Cessation
- 2006-10-27 AU AU2006306146A patent/AU2006306146A1/en not_active Abandoned
- 2006-10-27 JP JP2008537936A patent/JP2009513659A/ja active Pending
- 2006-10-27 TW TW095139947A patent/TW200819441A/zh unknown
- 2006-10-27 WO PCT/US2006/041739 patent/WO2007050732A1/en active Application Filing
- 2006-10-27 KR KR1020087012879A patent/KR20080067361A/ko not_active Application Discontinuation
- 2006-10-27 EP EP06817391A patent/EP1957464A1/en not_active Withdrawn
- 2006-10-27 UA UAA200807267A patent/UA94246C2/ru unknown
-
2008
- 2008-04-15 IL IL190899A patent/IL190899A0/en not_active IP Right Cessation
- 2008-04-25 ZA ZA200803674A patent/ZA200803674B/xx unknown
-
2012
- 2012-07-09 US US13/544,130 patent/US20120277190A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
NZ567358A (en) | 2011-10-28 |
TW200819441A (en) | 2008-05-01 |
CN101365684A (zh) | 2009-02-11 |
US20070099954A1 (en) | 2007-05-03 |
IL190899A0 (en) | 2008-11-03 |
US20120277190A1 (en) | 2012-11-01 |
WO2007050732A1 (en) | 2007-05-03 |
BRPI0617884A2 (pt) | 2011-08-09 |
AU2006306146A1 (en) | 2007-05-03 |
KR20080067361A (ko) | 2008-07-18 |
CA2626593A1 (en) | 2007-05-03 |
ZA200803674B (en) | 2009-11-25 |
JP2009513659A (ja) | 2009-04-02 |
CN102516176A (zh) | 2012-06-27 |
US8232309B2 (en) | 2012-07-31 |
RU2008121205A (ru) | 2009-12-10 |
EP1957464A1 (en) | 2008-08-20 |
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