UA91575C2 - Дендример-пег с четырьмя ветвями для коньюгирования с белками и пептидами - Google Patents

Дендример-пег с четырьмя ветвями для коньюгирования с белками и пептидами

Info

Publication number
UA91575C2
UA91575C2 UAA200808587A UAA200808587A UA91575C2 UA 91575 C2 UA91575 C2 UA 91575C2 UA A200808587 A UAA200808587 A UA A200808587A UA A200808587 A UAA200808587 A UA A200808587A UA 91575 C2 UA91575 C2 UA 91575C2
Authority
UA
Ukraine
Prior art keywords
conjugation
peptides
peg
proteins
dendrimer
Prior art date
Application number
UAA200808587A
Other languages
English (en)
Ukrainian (uk)
Inventor
Эрнандес Хосе Анхел Рамон
Одио Фидель Рауль Кастро
Мартинес Вивиан Мария Саес
МЕЙРЕЛЕС Роландо ПАЕС
Санчес Эдуардо Фернандес
Original Assignee
Сентро Де Инженьериа Генетика И Биотекнологиа
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Сентро Де Инженьериа Генетика И Биотекнологиа filed Critical Сентро Де Инженьериа Генетика И Биотекнологиа
Publication of UA91575C2 publication Critical patent/UA91575C2/ru

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/26—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/321—Polymers modified by chemical after-treatment with inorganic compounds
    • C08G65/325—Polymers modified by chemical after-treatment with inorganic compounds containing nitrogen

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Inorganic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polyethers (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)

Abstract

Полимерная дендримероподобная структура с четырьмя ветвями из монометоксиполиэтиленгликоля, которая может быть представлена как:.Карбоксильную группу предыдущей структуры можно функционально активировать для получения коньюгатов, которые представляют интерес в фармацевтике.Связывание этого дендримероподобного полиэтиленгликоля с терапевтическими белками улучшает их стабильность in vitro и in vivo.
UAA200808587A 2005-11-30 2006-11-20 Дендример-пег с четырьмя ветвями для коньюгирования с белками и пептидами UA91575C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CU20050241A CU23556A1 (es) 2005-11-30 2005-11-30 Estructura polimérica semejante a dendrímero para la obtención de conjugados de interés farmacéutico

Publications (1)

Publication Number Publication Date
UA91575C2 true UA91575C2 (ru) 2010-08-10

Family

ID=37672068

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200808587A UA91575C2 (ru) 2005-11-30 2006-11-20 Дендример-пег с четырьмя ветвями для коньюгирования с белками и пептидами

Country Status (17)

Country Link
US (1) US8703893B2 (ru)
EP (1) EP1967212B1 (ru)
JP (1) JP5123201B2 (ru)
KR (1) KR101134983B1 (ru)
CN (2) CN104906594B (ru)
AR (1) AR058841A1 (ru)
AU (1) AU2006319636B2 (ru)
BR (1) BRPI0604313A (ru)
CA (1) CA2631335C (ru)
CU (1) CU23556A1 (ru)
EG (1) EG26619A (ru)
MY (1) MY150739A (ru)
RU (1) RU2409389C2 (ru)
UA (1) UA91575C2 (ru)
UY (1) UY29981A1 (ru)
WO (1) WO2007062610A2 (ru)
ZA (1) ZA200804694B (ru)

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US8889635B2 (en) * 2008-09-30 2014-11-18 The Regents Of The University Of Michigan Dendrimer conjugates
US9017644B2 (en) 2008-11-07 2015-04-28 The Regents Of The University Of Michigan Methods of treating autoimmune disorders and/or inflammatory disorders
WO2010075423A2 (en) * 2008-12-23 2010-07-01 The Regents Of The University Of Michigan Dendrimer based modular platforms
CN102917699A (zh) * 2009-10-13 2013-02-06 密执安大学评议会 树枝状聚合物组合物和合成方法
WO2011059586A2 (en) 2009-10-30 2011-05-19 The Regents Of The University Of Michigan Multifunctional small molecules
US9402911B2 (en) 2011-12-08 2016-08-02 The Regents Of The University Of Michigan Multifunctional small molecules
WO2013096388A1 (en) 2011-12-21 2013-06-27 The Regents Of The University Of California Telodendrimers with enhanced drug delivery
US9642916B2 (en) 2012-12-12 2017-05-09 The Regents Of The University Of California Porphyrin modified telodendrimers
MY186423A (en) 2013-03-05 2021-07-22 Hanmi Pharm Ind Co Ltd Improved preparation method for high-yield production of physiologically active polypeptide conjugate
EP2786766A1 (en) * 2013-04-05 2014-10-08 Ufpeptides S.r.l. Supramolecular aggregates comprising maleimido cores
US9630909B2 (en) 2013-06-27 2017-04-25 Mylan Laboratories Ltd Process for the preparation of nepafenac
CU20140003A7 (es) * 2014-01-08 2015-08-27 Ct De Inmunología Molecular Biofarmacuba Conjugado que comprende eritropoyetina y una estructura polimérica ramificada
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AU2017205694B2 (en) 2016-01-08 2022-05-26 Ascendis Pharma Growth Disorders A/S Controlled-release CNP agonists with low NPR-C binding
KR20180100624A (ko) 2016-01-08 2018-09-11 아센디스 파마 그로우쓰 디스오더스 에이/에스 증가된 nep 안정성을 갖는 제어 방출성 cnp 작용제
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CA3007982C (en) 2016-01-08 2023-12-19 Ascendis Pharma Growth Disorders A/S Controlled-release cnp agonists with low initial npr-b activity
MX2018008061A (es) * 2016-01-08 2018-08-23 Ascendis Pharma Growth Disorders As Profarmacos de peptido natriuretico tipo c (cnp) con porciones portadoras grandes.
AU2017205688C1 (en) 2016-01-08 2022-03-10 Ascendis Pharma Growth Disorders A/S Cnp prodrugs with carrier attachment at the ring moiety
US11369688B2 (en) 2016-09-15 2022-06-28 The Regents Of The University Of California Hybrid telodendrimers
BR112019005351A2 (pt) 2016-09-29 2019-06-11 Ascendis Pharma Growth Disorders As terapia combinada com agonistas de cnp de liberação controlada
CN109134282B (zh) * 2017-06-28 2021-03-16 北京键凯科技股份有限公司 一种树状多缩乙二醇衍生物及其制备方法和应用
WO2019001473A1 (zh) * 2017-06-28 2019-01-03 北京键凯科技股份有限公司 一种树状多缩乙二醇衍生物及其制备方法和应用

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Also Published As

Publication number Publication date
BRPI0604313A (pt) 2007-01-30
MY150739A (en) 2014-02-28
ZA200804694B (en) 2009-03-25
KR101134983B1 (ko) 2012-04-09
KR20080072960A (ko) 2008-08-07
US20090082537A1 (en) 2009-03-26
CN104906594B (zh) 2016-12-28
RU2008126209A (ru) 2010-01-10
US8703893B2 (en) 2014-04-22
CA2631335A1 (en) 2007-06-07
CA2631335C (en) 2013-07-16
WO2007062610A3 (es) 2007-09-20
RU2409389C2 (ru) 2011-01-20
CU23556A1 (es) 2010-07-20
JP2009517414A (ja) 2009-04-30
AU2006319636A1 (en) 2007-06-07
CN104906594A (zh) 2015-09-16
AR058841A1 (es) 2008-02-27
UY29981A1 (es) 2007-06-29
WO2007062610A2 (es) 2007-06-07
EP1967212A2 (en) 2008-09-10
EP1967212B1 (en) 2016-09-21
AU2006319636B2 (en) 2012-10-18
EG26619A (en) 2014-04-08
CN101389354A (zh) 2009-03-18
JP5123201B2 (ja) 2013-01-23

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