UA88303C2 - Производные пиперидина, которые имеют активность по отношению к ccr5 (хемокинового рецептора 5) - Google Patents

Производные пиперидина, которые имеют активность по отношению к ccr5 (хемокинового рецептора 5)

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Publication number
UA88303C2
UA88303C2 UAA200613008A UAA200613008A UA88303C2 UA 88303 C2 UA88303 C2 UA 88303C2 UA A200613008 A UAA200613008 A UA A200613008A UA A200613008 A UAA200613008 A UA A200613008A UA 88303 C2 UA88303 C2 UA 88303C2
Authority
UA
Ukraine
Prior art keywords
modulators
chemokine receptor
receptor ccr5
derivates
piperidine
Prior art date
Application number
UAA200613008A
Other languages
English (en)
Ukrainian (uk)
Inventor
Говард Такер
Original Assignee
Астразенека Аб
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32733687&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA88303(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Астразенека Аб filed Critical Астразенека Аб
Publication of UA88303C2 publication Critical patent/UA88303C2/ru

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    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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Abstract

Соединения формулы (І), композиции, которые содержат их, способы их получения и их применение в медицинской терапии (например, для модуляции активности рецептора CCR5 у теплокровных животных).
UAA200613008A 2004-06-24 2005-06-20 Производные пиперидина, которые имеют активность по отношению к ccr5 (хемокинового рецептора 5) UA88303C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE0401657A SE0401657D0 (sv) 2004-06-24 2004-06-24 Chemical compounds

Publications (1)

Publication Number Publication Date
UA88303C2 true UA88303C2 (ru) 2009-10-12

Family

ID=32733687

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200613008A UA88303C2 (ru) 2004-06-24 2005-06-20 Производные пиперидина, которые имеют активность по отношению к ccr5 (хемокинового рецептора 5)

Country Status (22)

Country Link
US (1) US20070259914A1 (ru)
EP (1) EP1761494B1 (ru)
JP (1) JP5147393B2 (ru)
CN (1) CN101006058A (ru)
AR (1) AR049830A1 (ru)
AT (1) ATE465148T1 (ru)
AU (1) AU2005257707B2 (ru)
BR (1) BRPI0512420A (ru)
CA (1) CA2571087A1 (ru)
DE (1) DE602005020787D1 (ru)
ES (1) ES2342181T3 (ru)
IL (1) IL179729A0 (ru)
MX (1) MXPA06014413A (ru)
MY (1) MY139268A (ru)
NO (1) NO20070431L (ru)
RU (1) RU2381216C2 (ru)
SE (1) SE0401657D0 (ru)
TW (1) TW200610759A (ru)
UA (1) UA88303C2 (ru)
UY (1) UY28974A1 (ru)
WO (1) WO2006001751A1 (ru)
ZA (1) ZA200610526B (ru)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200610761A (en) 2004-04-23 2006-04-01 Astrazeneca Ab Chemical compounds
DE602007007497D1 (de) 2006-09-18 2010-08-12 Hoffmann La Roche Octahydropyrroloä3,4-cüpyrrolderivate und ihre verwendung als antivirale mittel
EP2173715A2 (en) * 2007-07-13 2010-04-14 Euroscreen S.A. Use of piperidine derivatives as agonists of chemokine receptor activity
WO2009151910A2 (en) * 2008-05-25 2009-12-17 Wyeth Combination product of receptor tyrosine kinase inhibitor and fatty acid synthase inhibitor for treating cancer
WO2012113103A1 (en) 2011-02-25 2012-08-30 Helsinn Healthcare S.A. Asymmetric ureas and medical uses thereof
GB201321746D0 (en) * 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
NO2699580T3 (ru) 2014-01-24 2018-02-24
KR102640774B1 (ko) 2016-03-22 2024-02-26 헬신 헬쓰케어 에스.에이. 벤젠술포닐-비대칭 우레아 및 그의 의학적 용도
WO2020132552A1 (en) * 2018-12-21 2020-06-25 Ca*Tx, Inc. Pharmaceutical combinations for the treatment of cancer

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9624482D0 (en) 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
SK285141B6 (sk) 1996-02-13 2006-07-07 Astrazeneca Uk Limited Použitie chinazolínového derivátu, chinazolínový derivát, spôsob jeho prípravy a farmaceutická kompozícia, ktorá ho obsahuje
EP0885198B1 (en) 1996-03-05 2001-12-19 AstraZeneca AB 4-anilinoquinazoline derivatives
GB9718972D0 (en) 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
GB9714249D0 (en) 1997-07-08 1997-09-10 Angiogene Pharm Ltd Vascular damaging agents
CN1279668A (zh) * 1997-11-18 2001-01-10 帝人株式会社 环胺衍生物及其作为药物的用途
GB9900334D0 (en) 1999-01-07 1999-02-24 Angiogene Pharm Ltd Tricylic vascular damaging agents
GB9900752D0 (en) 1999-01-15 1999-03-03 Angiogene Pharm Ltd Benzimidazole vascular damaging agents
SE9902987D0 (sv) * 1999-08-24 1999-08-24 Astra Pharma Prod Novel compounds
MXPA02011770A (es) 2000-05-31 2003-04-10 Astrazeneca Ab Derivados de indol con actividad de dano vascular.
WO2002008213A1 (en) 2000-07-07 2002-01-31 Angiogene Pharmaceuticals Limited Colchinol derivatives as angiogenesis inhibitors
IL153484A0 (en) 2000-07-07 2003-07-06 Angiogene Pharm Ltd Colchinol derivatives as angiogenesis inhibitors
SE0103818D0 (sv) 2001-11-15 2001-11-15 Astrazeneca Ab Chemical compounds
CN1744899A (zh) * 2002-12-13 2006-03-08 史密丝克莱恩比彻姆公司 作为ccr5拮抗剂的哌啶衍生物
AR042628A1 (es) * 2002-12-20 2005-06-29 Astrazeneca Ab Derivados de piperidina como moduladores del receptor ccr5

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