UA84300C2 - ПРОИЗВОДНЫЕ ГЕКСА- И ОКТАГИДРОПИРИДО[1,2-a]ПИРАЗИНА С АНТАГОНИСТИЧЕСКОЙ АКТИВНОСТЬЮ ОТНОСИТЕЛЬНО NK1 - Google Patents
ПРОИЗВОДНЫЕ ГЕКСА- И ОКТАГИДРОПИРИДО[1,2-a]ПИРАЗИНА С АНТАГОНИСТИЧЕСКОЙ АКТИВНОСТЬЮ ОТНОСИТЕЛЬНО NK1Info
- Publication number
- UA84300C2 UA84300C2 UAA200604635A UAA200604635A UA84300C2 UA 84300 C2 UA84300 C2 UA 84300C2 UA A200604635 A UAA200604635 A UA A200604635A UA A200604635 A UAA200604635 A UA A200604635A UA 84300 C2 UA84300 C2 UA 84300C2
- Authority
- UA
- Ukraine
- Prior art keywords
- pyrido
- antagonistic activity
- pyrazine derivatives
- octahydro
- hexa
- Prior art date
Links
- 230000003042 antagnostic effect Effects 0.000 title abstract 2
- ONHPOXROAPYCGT-UHFFFAOYSA-N 2,3,4,6,7,8,9,9a-octahydro-1h-pyrido[1,2-a]pyrazine Chemical class C1CNCC2CCCCN21 ONHPOXROAPYCGT-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- GXWNSJYVSIJRLS-UHFFFAOYSA-N 6-bromo-8-methylimidazo[1,2-a]pyrazine Chemical class CC1=NC(Br)=CN2C=CN=C12 GXWNSJYVSIJRLS-UHFFFAOYSA-N 0.000 abstract 1
- 102000009493 Neurokinin receptors Human genes 0.000 abstract 1
- 108050000302 Neurokinin receptors Proteins 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Otolaryngology (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Obesity (AREA)
- Anesthesiology (AREA)
- Addiction (AREA)
- Child & Adolescent Psychology (AREA)
- Vascular Medicine (AREA)
- Nutrition Science (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
Abstract
Изобретение касается производных гекса- и октагидропиридо[1,2-а]пиразина, которые имеют антагонистическую активность относительно рецептора нейрокинина-NK.Изобретение также касается способов получения этих соединений, фармацевтических композиций, которые содержат фармакологически действующее количество, по крайней мере, одного из этих соединений как действующее вещество, а также применения таких композиций для лечения расстройств, связанных с рецепторами нейрокинина.Изобретение касается соединений, представленных общей формулой (1),, (1)где обозначения имеют значения, приведенные в описании изобретения.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US50587303P | 2003-09-26 | 2003-09-26 | |
EP03103566 | 2003-09-26 | ||
PCT/EP2004/052277 WO2005030214A1 (en) | 2003-09-26 | 2004-09-23 | HEXA- AND OCTAHYDRO-PYRIDO[1,2-a]PYRAZINE DERIVATIVES WITH NK1 ANTAGONISTIC ACTIVITY |
Publications (1)
Publication Number | Publication Date |
---|---|
UA84300C2 true UA84300C2 (ru) | 2008-10-10 |
Family
ID=34924105
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UAA200604635A UA84300C2 (ru) | 2003-09-26 | 2004-09-23 | ПРОИЗВОДНЫЕ ГЕКСА- И ОКТАГИДРОПИРИДО[1,2-a]ПИРАЗИНА С АНТАГОНИСТИЧЕСКОЙ АКТИВНОСТЬЮ ОТНОСИТЕЛЬНО NK1 |
Country Status (14)
Country | Link |
---|---|
US (1) | US7244734B2 (ru) |
EP (1) | EP1663238B1 (ru) |
JP (1) | JP2007506710A (ru) |
AR (1) | AR045796A1 (ru) |
AT (1) | ATE439132T1 (ru) |
AU (1) | AU2004275530B8 (ru) |
BR (1) | BRPI0414644A (ru) |
CA (1) | CA2539444A1 (ru) |
MX (1) | MXPA06003373A (ru) |
RU (1) | RU2349591C2 (ru) |
SA (1) | SA04250304B1 (ru) |
TW (1) | TW200514785A (ru) |
UA (1) | UA84300C2 (ru) |
WO (1) | WO2005030214A1 (ru) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2465274C2 (ru) * | 2010-03-05 | 2012-10-27 | Общество с ограниченной ответственностью "Инновационные фармакологические разработки" | Производное пиридопиразиндиона и его применение в качестве противоязвенного средства |
PT2968320T (pt) | 2013-03-15 | 2021-01-28 | Intra Cellular Therapies Inc | Compostos orgânicos |
CA2932610C (en) | 2013-12-03 | 2023-08-22 | Intra-Cellular Therapies, Inc. | Heterocycle fused gamma-carboline compounds for use in treatment of schizophrenia |
PL3125893T3 (pl) | 2014-04-04 | 2024-02-12 | Intra-Cellular Therapies, Inc. | Deuterowane gamma-karboliny w fuzji z heterocyklami jako antagoniści receptorów 5-HT2A |
JP6686168B2 (ja) | 2016-03-25 | 2020-04-22 | イントラ−セルラー・セラピーズ・インコーポレイテッドIntra−Cellular Therapies, Inc. | 有機化合物 |
CN110072518B (zh) | 2016-10-12 | 2021-10-26 | 细胞内治疗公司 | 无定形固体分散体 |
JP7132939B2 (ja) | 2017-03-24 | 2022-09-07 | イントラ-セルラー・セラピーズ・インコーポレイテッド | 新規組成物および方法 |
CN112584838A (zh) | 2018-08-31 | 2021-03-30 | 细胞内治疗公司 | 新方法 |
US11957791B2 (en) | 2018-08-31 | 2024-04-16 | Intra-Cellular Therapies, Inc. | Methods |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1125112A (en) * | 1966-01-07 | 1968-08-28 | Science Union & Cie | New derivatives of diazabicyclo-decane and process for preparing them |
IL111730A (en) | 1993-11-29 | 1998-12-06 | Fujisawa Pharmaceutical Co | Piperazine derivatives, processes for their preparation and pharmaceutical preparations containing them |
EP0982030A3 (en) * | 1998-08-17 | 2000-05-10 | Pfizer Products Inc. | 2,7-substituted octahydro-pyrrolo 1,2-a]pyrazine derivatives as 5ht 1a ligands |
UA77515C2 (en) | 2002-04-04 | 2006-12-15 | Diazabicyclo alkane derivatives possessing neuroldnin-nk1 receptor antagonistic activity |
-
2004
- 2004-09-22 SA SA04250304A patent/SA04250304B1/ar unknown
- 2004-09-22 AR ARP040103401A patent/AR045796A1/es not_active Application Discontinuation
- 2004-09-22 TW TW093128700A patent/TW200514785A/zh unknown
- 2004-09-22 US US10/946,176 patent/US7244734B2/en not_active Expired - Fee Related
- 2004-09-23 RU RU2006114051/04A patent/RU2349591C2/ru not_active IP Right Cessation
- 2004-09-23 AU AU2004275530A patent/AU2004275530B8/en not_active Expired - Fee Related
- 2004-09-23 EP EP04766840A patent/EP1663238B1/en active Active
- 2004-09-23 BR BRPI0414644-1A patent/BRPI0414644A/pt not_active IP Right Cessation
- 2004-09-23 UA UAA200604635A patent/UA84300C2/ru unknown
- 2004-09-23 MX MXPA06003373A patent/MXPA06003373A/es active IP Right Grant
- 2004-09-23 CA CA002539444A patent/CA2539444A1/en not_active Abandoned
- 2004-09-23 JP JP2006527417A patent/JP2007506710A/ja not_active Withdrawn
- 2004-09-23 WO PCT/EP2004/052277 patent/WO2005030214A1/en active Application Filing
- 2004-09-23 AT AT04766840T patent/ATE439132T1/de not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
AR045796A1 (es) | 2005-11-16 |
AU2004275530A1 (en) | 2005-04-07 |
RU2006114051A (ru) | 2007-11-20 |
US7244734B2 (en) | 2007-07-17 |
WO2005030214A1 (en) | 2005-04-07 |
EP1663238A1 (en) | 2006-06-07 |
MXPA06003373A (es) | 2006-06-08 |
AU2004275530B8 (en) | 2009-08-20 |
ATE439132T1 (de) | 2009-08-15 |
RU2349591C2 (ru) | 2009-03-20 |
JP2007506710A (ja) | 2007-03-22 |
SA04250304B1 (ar) | 2009-03-11 |
EP1663238B1 (en) | 2009-08-12 |
BRPI0414644A (pt) | 2006-11-14 |
CA2539444A1 (en) | 2005-04-07 |
AU2004275530B2 (en) | 2009-07-30 |
US20050070548A1 (en) | 2005-03-31 |
TW200514785A (en) | 2005-05-01 |
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