UA81420C2 - Process for the preparation of substituted pyrimidines and pyrimidine derivatives as inhibitors of protein kinase - Google Patents

Process for the preparation of substituted pyrimidines and pyrimidine derivatives as inhibitors of protein kinase

Info

Publication number
UA81420C2
UA81420C2 UAA200500520A UA2005000520A UA81420C2 UA 81420 C2 UA81420 C2 UA 81420C2 UA A200500520 A UAA200500520 A UA A200500520A UA 2005000520 A UA2005000520 A UA 2005000520A UA 81420 C2 UA81420 C2 UA 81420C2
Authority
UA
Ukraine
Prior art keywords
inhibitors
preparation
substituted pyrimidines
protein kinase
pyrimidine derivatives
Prior art date
Application number
UAA200500520A
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Priority claimed from PCT/US2003/019266 external-priority patent/WO2004000833A1/en
Publication of UA81420C2 publication Critical patent/UA81420C2/en

Links

Abstract

The present invention provides a facile process for the preparation of tri-and tetra-substituted pyrimidines. The process is useful for preparing inhibitors of protein kinases, especially Aurora kinase. These inhibitors are useful for treating or lessening the severity of Aurora-mediated diseases or conditions.
UAA200500520A 2002-06-20 2003-06-19 Process for the preparation of substituted pyrimidines and pyrimidine derivatives as inhibitors of protein kinase UA81420C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39065802P 2002-06-20 2002-06-20
PCT/US2003/019266 WO2004000833A1 (en) 2002-06-20 2003-06-19 Processes for preparing substituted pyrimidines and pyrimidine derivatives as inhibitors of protein kinase

Publications (1)

Publication Number Publication Date
UA81420C2 true UA81420C2 (en) 2008-01-10

Family

ID=38181247

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200500520A UA81420C2 (en) 2002-06-20 2003-06-19 Process for the preparation of substituted pyrimidines and pyrimidine derivatives as inhibitors of protein kinase

Country Status (4)

Country Link
CN (1) CN101012200A (en)
ES (1) ES2361335T3 (en)
UA (1) UA81420C2 (en)
ZA (1) ZA200500414B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2890018A1 (en) * 2012-11-05 2014-05-08 Nant Holdings Ip, Llc Substituted indol-5-ol derivatives and their therapeutical applications
RU2015143657A (en) * 2013-03-15 2017-04-27 Нэнтбайосайенс, Инк. SUBSTITUTED INDOL-5-OLA DERIVATIVES AND THEIR THERAPEUTIC APPLICATIONS

Also Published As

Publication number Publication date
ZA200500414B (en) 2006-07-26
CN101012200A (en) 2007-08-08
ES2361335T3 (en) 2011-06-16

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