UA46669C2 - Production of controlled-release dosage forms of insulin - Google Patents

Production of controlled-release dosage forms of insulin

Info

Publication number
UA46669C2
UA46669C2 UA2001129232A UA2001129232A UA46669C2 UA 46669 C2 UA46669 C2 UA 46669C2 UA 2001129232 A UA2001129232 A UA 2001129232A UA 2001129232 A UA2001129232 A UA 2001129232A UA 46669 C2 UA46669 C2 UA 46669C2
Authority
UA
Ukraine
Prior art keywords
insulin
ester
dosage forms
production
release dosage
Prior art date
Application number
UA2001129232A
Other languages
Russian (ru)
Ukrainian (uk)
Inventor
Олексій Павлович Лазарев
Валентина Миколаївна Рибачук
Валентина Николаевна Рыбачук
Дмитро Павлович Прудієв
Світлана Олексіївна Пояркова
Ігор Павлович Лесик
Игорь Павлович Лесик
Павло Павлович Сологуб
Володимир Романович Луців
Владимир Романович Луцив
Валерій Миколайович Мельник
Людмила Павлівна Соляник
Микола Миколайович Власенко
Віктор Іванович Стадник
Original Assignee
Товариство З Обмеженою Відповідальністю "Мако"
Общество С Ограниченной Ответственностью «Мако»
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Товариство З Обмеженою Відповідальністю "Мако", Общество С Ограниченной Ответственностью «Мако» filed Critical Товариство З Обмеженою Відповідальністю "Мако"
Priority to UA2001129232A priority Critical patent/UA46669C2/en
Priority to RU2002135042/15A priority patent/RU2252782C2/en
Publication of UA46669C2 publication Critical patent/UA46669C2/en

Links

Abstract

The invention relates to the chemical and pharmaceutical industry and may be used for production of high-quality controlled-release dosage forms of insulin. The ester of human insulin is prepared by transpeptidation of porcine insulin using the excess of di-tret-butyl ester of threonine in aqueous-organic medium in the presence of trypsin. The ester of insulin is purified by chromatography, the protective groups are removed, and insulin is crystallized and dissolved in the diluted acid. Then acidified solutions of zinc ions and protamine sulfate are added, the solution is mixed with the buffered solutions of m-cresol, phenol and glycerol, the solution is kept until the crystals are generated. 100-500-fold excess of di-tret-butyl ester of threonine is used for transpeptidation at a 1 to 300-1000 ratio of trypsin to porcine insulin. The reaction mixture is diluted 2-3-fold with water. The ester of human insulin and crystallized human insulin are purified step-by-step by high performance liquid chromatography followed by dissolution of insulin crystals in the diluted acid.  
UA2001129232A 2001-12-29 2001-12-29 Production of controlled-release dosage forms of insulin UA46669C2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
UA2001129232A UA46669C2 (en) 2001-12-29 2001-12-29 Production of controlled-release dosage forms of insulin
RU2002135042/15A RU2252782C2 (en) 2001-12-29 2002-12-26 Method for production of insulin drug of durable action

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
UA2001129232A UA46669C2 (en) 2001-12-29 2001-12-29 Production of controlled-release dosage forms of insulin

Publications (1)

Publication Number Publication Date
UA46669C2 true UA46669C2 (en) 2005-12-15

Family

ID=35824764

Family Applications (1)

Application Number Title Priority Date Filing Date
UA2001129232A UA46669C2 (en) 2001-12-29 2001-12-29 Production of controlled-release dosage forms of insulin

Country Status (2)

Country Link
RU (1) RU2252782C2 (en)
UA (1) UA46669C2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008145730A1 (en) * 2007-06-01 2008-12-04 Novo Nordisk A/S Stable non-aqueous pharmaceutical compositions
WO2009115469A1 (en) 2008-03-18 2009-09-24 Novo Nordisk A/S Protease stabilized, acylated insulin analogues
WO2013153000A2 (en) 2012-04-11 2013-10-17 Novo Nordisk A/S Insulin formulations
HUE055231T2 (en) 2016-12-16 2021-11-29 Novo Nordisk As Insulin containing pharmaceutical compositions

Also Published As

Publication number Publication date
RU2252782C2 (en) 2005-05-27

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