UA46669C2 - Production of controlled-release dosage forms of insulin - Google Patents
Production of controlled-release dosage forms of insulinInfo
- Publication number
- UA46669C2 UA46669C2 UA2001129232A UA2001129232A UA46669C2 UA 46669 C2 UA46669 C2 UA 46669C2 UA 2001129232 A UA2001129232 A UA 2001129232A UA 2001129232 A UA2001129232 A UA 2001129232A UA 46669 C2 UA46669 C2 UA 46669C2
- Authority
- UA
- Ukraine
- Prior art keywords
- insulin
- ester
- dosage forms
- production
- release dosage
- Prior art date
Links
Abstract
The invention relates to the chemical and pharmaceutical industry and may be used for production of high-quality controlled-release dosage forms of insulin. The ester of human insulin is prepared by transpeptidation of porcine insulin using the excess of di-tret-butyl ester of threonine in aqueous-organic medium in the presence of trypsin. The ester of insulin is purified by chromatography, the protective groups are removed, and insulin is crystallized and dissolved in the diluted acid. Then acidified solutions of zinc ions and protamine sulfate are added, the solution is mixed with the buffered solutions of m-cresol, phenol and glycerol, the solution is kept until the crystals are generated. 100-500-fold excess of di-tret-butyl ester of threonine is used for transpeptidation at a 1 to 300-1000 ratio of trypsin to porcine insulin. The reaction mixture is diluted 2-3-fold with water. The ester of human insulin and crystallized human insulin are purified step-by-step by high performance liquid chromatography followed by dissolution of insulin crystals in the diluted acid.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
UA2001129232A UA46669C2 (en) | 2001-12-29 | 2001-12-29 | Production of controlled-release dosage forms of insulin |
RU2002135042/15A RU2252782C2 (en) | 2001-12-29 | 2002-12-26 | Method for production of insulin drug of durable action |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
UA2001129232A UA46669C2 (en) | 2001-12-29 | 2001-12-29 | Production of controlled-release dosage forms of insulin |
Publications (1)
Publication Number | Publication Date |
---|---|
UA46669C2 true UA46669C2 (en) | 2005-12-15 |
Family
ID=35824764
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UA2001129232A UA46669C2 (en) | 2001-12-29 | 2001-12-29 | Production of controlled-release dosage forms of insulin |
Country Status (2)
Country | Link |
---|---|
RU (1) | RU2252782C2 (en) |
UA (1) | UA46669C2 (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008145730A1 (en) * | 2007-06-01 | 2008-12-04 | Novo Nordisk A/S | Stable non-aqueous pharmaceutical compositions |
WO2009115469A1 (en) | 2008-03-18 | 2009-09-24 | Novo Nordisk A/S | Protease stabilized, acylated insulin analogues |
WO2013153000A2 (en) | 2012-04-11 | 2013-10-17 | Novo Nordisk A/S | Insulin formulations |
HUE055231T2 (en) | 2016-12-16 | 2021-11-29 | Novo Nordisk As | Insulin containing pharmaceutical compositions |
-
2001
- 2001-12-29 UA UA2001129232A patent/UA46669C2/en unknown
-
2002
- 2002-12-26 RU RU2002135042/15A patent/RU2252782C2/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
RU2252782C2 (en) | 2005-05-27 |
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