UA41362C2 - Тіазолідиндіони, спосіб їх отримання та лікарський засіб - Google Patents
Тіазолідиндіони, спосіб їх отримання та лікарський засібInfo
- Publication number
- UA41362C2 UA41362C2 UA95114968A UA95114968A UA41362C2 UA 41362 C2 UA41362 C2 UA 41362C2 UA 95114968 A UA95114968 A UA 95114968A UA 95114968 A UA95114968 A UA 95114968A UA 41362 C2 UA41362 C2 UA 41362C2
- Authority
- UA
- Ukraine
- Prior art keywords
- thiazolidindons
- heteroatoms
- atoms
- alkyl
- nitrogen
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 4
- 125000004429 atom Chemical group 0.000 abstract 3
- 229910052760 oxygen Inorganic materials 0.000 abstract 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- 125000006274 (C1-C3)alkoxy group Chemical group 0.000 abstract 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- -1 R - naphthyl Chemical group 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000005864 Sulphur Substances 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 125000002837 carbocyclic group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Obesity (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Предметом цього винаходу є тіазолідиндіони, спосіб їх отримання і лікарські засоби, що містять їх. Тіазолідиндіони формули (I): в якій А означає карбоциклічне кільце з 5 або 6 атомами вуглецю або гетероциклічне кільце з 1 або 2 гетероатомами, причому гетероатоми означають кисень, азот або сірку, а гетероцикли, при необхідності, можуть нести на одному або декількох атомах азоту один атом кисню, В - -СН=СН-, -N=CH-, -СН=N-, W - СН2, О, СН(ОН) або СО, Х - S, О або NR2, причому залишок R2 є воднем, Y-N, R - нафтил, піридил, фурил, тієніл або фенил, при необхідності одно- або двозаміщений С1-Сз- алкілом, СFз, С1-Сз--алкокси, F, CI або бромом, R1 - водень або С1-С6-алкіл, і n = 2, а також їх таутомери, енантіомери, діастереомери і фізіологічно прийнятні солі.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4317320A DE4317320A1 (de) | 1993-05-25 | 1993-05-25 | Neue Thiazolidindione und diese enthaltende Arzneimittel |
| PCT/EP1994/001619 WO1994027995A1 (de) | 1993-05-25 | 1994-05-19 | Neue thiazolidindione und diese enthaltende arzneimittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA41362C2 true UA41362C2 (uk) | 2001-09-17 |
Family
ID=6488833
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA95114968A UA41362C2 (uk) | 1993-05-25 | 1994-05-19 | Тіазолідиндіони, спосіб їх отримання та лікарський засіб |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US5599826A (uk) |
| EP (1) | EP0700397B1 (uk) |
| JP (1) | JP3162721B2 (uk) |
| KR (1) | KR100243783B1 (uk) |
| CN (1) | CN1040324C (uk) |
| AT (1) | ATE223409T1 (uk) |
| AU (1) | AU682699B2 (uk) |
| CA (1) | CA2163028C (uk) |
| CL (1) | CL2004001167A1 (uk) |
| CY (1) | CY2415B1 (uk) |
| CZ (1) | CZ285927B6 (uk) |
| DE (2) | DE4317320A1 (uk) |
| DK (1) | DK0700397T3 (uk) |
| ES (1) | ES2180581T3 (uk) |
| FI (1) | FI955685A0 (uk) |
| HU (1) | HU217065B (uk) |
| NO (1) | NO307832B1 (uk) |
| NZ (1) | NZ267410A (uk) |
| PL (1) | PL180046B1 (uk) |
| PT (1) | PT700397E (uk) |
| RO (1) | RO114328B1 (uk) |
| RU (1) | RU2122002C1 (uk) |
| SK (1) | SK282618B6 (uk) |
| UA (1) | UA41362C2 (uk) |
| WO (1) | WO1994027995A1 (uk) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH07138258A (ja) * | 1993-11-16 | 1995-05-30 | Taiho Yakuhin Kogyo Kk | チアゾリジンジオン誘導体又はその塩 |
| CN1064682C (zh) * | 1995-07-31 | 2001-04-18 | 盐野义制药株式会社 | 具有磷脂酶a2抑制活性的吡咯烷衍生物 |
| JPH09176162A (ja) * | 1995-12-22 | 1997-07-08 | Toubishi Yakuhin Kogyo Kk | チアゾリジンジオン誘導体及びその製造法並びにそれを含む医薬組成物 |
| DE19619819A1 (de) * | 1996-05-16 | 1997-11-20 | Boehringer Mannheim Gmbh | Neue Thiazolidindione, Verfahren zu ihrer Herstellung und diese enthaltenden Arzneimittel |
| DE19711617A1 (de) * | 1997-03-20 | 1998-09-24 | Boehringer Mannheim Gmbh | Neue Thiazolidindione, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel |
| DE19711616A1 (de) * | 1997-03-20 | 1998-09-24 | Boehringer Mannheim Gmbh | Verbessertes Verfahren zur Herstellung von Thiazolidindionen |
| US6028088A (en) * | 1998-10-30 | 2000-02-22 | The University Of Mississippi | Flavonoid derivatives |
| GB9824893D0 (en) * | 1998-11-12 | 1999-01-06 | Smithkline Beckman Corp | Novel method of treatment |
| EP1143953A3 (en) * | 1998-11-20 | 2002-02-06 | Genentech, Inc. | Method of inhibiting angiogenesis |
| ATE319702T1 (de) | 1999-08-02 | 2006-03-15 | Verfahren zur herstellung von benzothiophen- derivaten | |
| US6531609B2 (en) | 2000-04-14 | 2003-03-11 | Hoffmann-La Roche Inc. | Process for the preparation of thiazolidinedione derivatives |
| EP1283830B1 (en) * | 2000-05-08 | 2008-06-18 | F. Hoffmann-La Roche Ag | Para-amine substituted phenylamide glucokinase activators |
| EP1296656B1 (en) | 2000-06-27 | 2006-08-02 | F. Hoffmann-La Roche Ag | Method for preparing a composition |
| ES2291378T3 (es) * | 2000-12-25 | 2008-03-01 | Ono Pharmaceutical Co., Ltd. | Compuestos derivados de dihidronaftaleno y medicamentos que utilizan estos compuestos como ingrediente activo. |
| US7323481B2 (en) | 2001-04-06 | 2008-01-29 | Hoffmann-La Roche Inc. | Thiazolidinediones alone or in combination with other therapeutic agents for inhibiting or reducing tumour growth |
| IL158589A0 (en) * | 2001-05-15 | 2004-05-12 | Hoffmann La Roche | Carboxylic acid substituted oxazole derivatives for use as ppar-alpha and -gamma activators in the treatment of diabetes |
| JP2003040877A (ja) * | 2001-07-24 | 2003-02-13 | Sumika Fine Chemicals Co Ltd | ５−［６−（２−フルオロベンジルオキシ）−２−ナフチル］メチル−２，４−チアゾリジンジオンの製造方法及びその精製方法 |
| US7102000B2 (en) * | 2002-03-08 | 2006-09-05 | Incyte San Diego Inc. | Heterocyclic amide derivatives for the treatment of diabetes and other diseases |
| MXPA04012840A (es) * | 2002-07-03 | 2005-02-24 | Hoffmann La Roche | Derivados de oxazol y su uso como sensibilizadores a la insulina. |
| RU2296754C2 (ru) * | 2002-08-30 | 2007-04-10 | Ф.Хоффманн-Ля Рош Аг | НОВЫЕ СОЕДИНЕНИЯ 2-АРИЛТИАЗОЛА В КАЧЕСТВЕ АГОНИСТОВ PPAR α И PPAR γ |
| EP1539746B1 (en) * | 2002-09-12 | 2006-11-15 | F. Hoffmann-La Roche Ag | N-substituted-1h-indol-5-propionic acid compounds as ppar agonists useful for the treatment of diabetes |
| EP1567523B1 (en) * | 2002-11-25 | 2008-08-20 | F.Hoffmann-La Roche Ag | Indolyl derivatives |
| CN1809562A (zh) | 2003-06-26 | 2006-07-26 | 霍夫曼-拉罗奇有限公司 | 制备胰岛素敏化剂及其中间体化合物的方法 |
| CN101693202B (zh) * | 2009-10-21 | 2011-04-20 | 沧州那瑞化学科技有限公司 | 盐酸吡咯列酮关键中间体加氢反应催化剂及加氢反应方法 |
| WO2013082106A1 (en) | 2011-12-02 | 2013-06-06 | The General Hospital Corporation | Differentiation into brown adipocytes |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1003445B (zh) * | 1984-10-03 | 1989-03-01 | 武田药品工业株式会社 | 噻唑烷二酮衍生物，其制备方法和用途 |
| US4703052A (en) * | 1985-05-21 | 1987-10-27 | Pfizer Inc. | Hypoglycemic thiazolidinediones |
| GB8713861D0 (en) * | 1987-06-13 | 1987-07-15 | Beecham Group Plc | Compounds |
| ATE104626T1 (de) * | 1988-03-04 | 1994-05-15 | Volk Inc Kurt H | Gegenstand fuer den unmittelbaren versand per post mit einer postversandfaehigen antwortkarte. |
| HU217432B (hu) * | 1988-03-08 | 2000-01-28 | Pfizer Inc. | Eljárás tiazolidin-dion-származékok és az ezeket tartalmazó gyógyszerkészítmények előállítására, a vegyületek és a készítmények |
| PL296945A1 (uk) * | 1990-07-03 | 1992-07-13 | Yamanouchi Pharma Co Ltd | |
| FR2688220A1 (fr) * | 1992-03-06 | 1993-09-10 | Adir | Nouveaux derives de thiazolidine-2,4-dione, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
-
1993
- 1993-05-25 DE DE4317320A patent/DE4317320A1/de not_active Withdrawn
-
1994
- 1994-05-19 JP JP50018495A patent/JP3162721B2/ja not_active Expired - Fee Related
- 1994-05-19 RU RU95122667A patent/RU2122002C1/ru not_active IP Right Cessation
- 1994-05-19 UA UA95114968A patent/UA41362C2/uk unknown
- 1994-05-19 DE DE59410181T patent/DE59410181D1/de not_active Expired - Fee Related
- 1994-05-19 PL PL94311752A patent/PL180046B1/pl not_active IP Right Cessation
- 1994-05-19 DK DK94918342T patent/DK0700397T3/da active
- 1994-05-19 NZ NZ267410A patent/NZ267410A/en not_active IP Right Cessation
- 1994-05-19 ES ES94918342T patent/ES2180581T3/es not_active Expired - Lifetime
- 1994-05-19 KR KR1019950705207A patent/KR100243783B1/ko not_active IP Right Cessation
- 1994-05-19 HU HU9503376A patent/HU217065B/hu not_active IP Right Cessation
- 1994-05-19 AU AU69704/94A patent/AU682699B2/en not_active Ceased
- 1994-05-19 RO RO95-01981A patent/RO114328B1/ro unknown
- 1994-05-19 CN CN94192240A patent/CN1040324C/zh not_active Expired - Fee Related
- 1994-05-19 CZ CZ952999A patent/CZ285927B6/cs not_active IP Right Cessation
- 1994-05-19 US US08/578,561 patent/US5599826A/en not_active Expired - Fee Related
- 1994-05-19 WO PCT/EP1994/001619 patent/WO1994027995A1/de active IP Right Grant
- 1994-05-19 EP EP94918342A patent/EP0700397B1/de not_active Expired - Lifetime
- 1994-05-19 CA CA002163028A patent/CA2163028C/en not_active Expired - Fee Related
- 1994-05-19 PT PT94918342T patent/PT700397E/pt unknown
- 1994-05-19 AT AT94918342T patent/ATE223409T1/de not_active IP Right Cessation
- 1994-05-19 SK SK1461-95A patent/SK282618B6/sk not_active IP Right Cessation
-
1995
- 1995-11-24 NO NO954762A patent/NO307832B1/no unknown
- 1995-11-24 FI FI955685A patent/FI955685A0/fi not_active Application Discontinuation
-
2003
- 2003-09-11 CY CY0300064A patent/CY2415B1/xx unknown
-
2004
- 2004-05-20 CL CL200401167A patent/CL2004001167A1/es unknown
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