UA41312C2 - Гідрати 7-[7-(s)-аміно-5-азаспіро[2,4]гептан-5-іл]-8-хлор-6-фтор-1-[(1r,2s)-2-фторциклопропіл]-4-оксо-1,4-дигідрохінолін-3-карбонової кислоти, спосіб їх одержання і фармацевтична композиція - Google Patents

Гідрати 7-[7-(s)-аміно-5-азаспіро[2,4]гептан-5-іл]-8-хлор-6-фтор-1-[(1r,2s)-2-фторциклопропіл]-4-оксо-1,4-дигідрохінолін-3-карбонової кислоти, спосіб їх одержання і фармацевтична композиція

Info

Publication number
UA41312C2
UA41312C2 UA94095787A UA94095787A UA41312C2 UA 41312 C2 UA41312 C2 UA 41312C2 UA 94095787 A UA94095787 A UA 94095787A UA 94095787 A UA94095787 A UA 94095787A UA 41312 C2 UA41312 C2 UA 41312C2
Authority
UA
Ukraine
Prior art keywords
azaspiro
heptane
oxo
chloro
amino
Prior art date
Application number
UA94095787A
Other languages
English (en)
Russian (ru)
Inventor
Іуіті Кімура
Иуити Кимура
Кацухіро Кавакамі
Кацухиро КАВАКАМИ
Норімаса Міката
Норимаса Миката
Кейдзі Утіяма
Кейдзи Утияма
Тазуо Уємура
Тазуо Уемура
Юзуке Юкімото
Юзуке Юкимото
Original Assignee
Дайіті Фармасьютікал Ко., Лтд.
Дайити Фармасьютикал Ко., Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Дайіті Фармасьютікал Ко., Лтд., Дайити Фармасьютикал Ко., Лтд. filed Critical Дайіті Фармасьютікал Ко., Лтд.
Publication of UA41312C2 publication Critical patent/UA41312C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Quinoline Compounds (AREA)

Abstract

Спосіб селективного одержання 3/2 гідрату 7-[7-(S) аміно-5-азаспіро[2,4]гептан-5-іл]-8-хлор-6-фтор-1-[(1R,2S)-2-фторциклопропіл]-4-оксо-1,4-дігідрохінолін-3-карбонової кислоти включає обробку 7-[7-(S)-аміно-5-азаспіро[2,4]гептан-5-іл]-8-хлор-6-фтор-1-[(1 R, 2S)-2-фторциклопропіл]-4-оксо-1,4-дігідрохінолін-З-карбонової кислоти у водному розчиннику, де мінімальний вміст води в даному водному розчиннику складає, принаймні, 40 % при 25 °С і, принаймні, 90 % при 60 °С, або перекристалізацію 7-[7-(S)-аміно-5-азаспіро[2,4]гептан-5-іл]-8-хлор-6-фтор-1-[(1R,2S)-2-фторциклопропіл]-4-оксо-1,4-дігідрохінолін-3-карбонової кислоти з водного розчинника, де вміст води в згаданому водному розчиннику складає від 50 % до 100 %, переважно від 50% до 75%.
UA94095787A 1993-09-10 1994-09-08 Гідрати 7-[7-(s)-аміно-5-азаспіро[2,4]гептан-5-іл]-8-хлор-6-фтор-1-[(1r,2s)-2-фторциклопропіл]-4-оксо-1,4-дигідрохінолін-3-карбонової кислоти, спосіб їх одержання і фармацевтична композиція UA41312C2 (uk)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP22538093 1993-09-10

Publications (1)

Publication Number Publication Date
UA41312C2 true UA41312C2 (uk) 2001-09-17

Family

ID=16828452

Family Applications (1)

Application Number Title Priority Date Filing Date
UA94095787A UA41312C2 (uk) 1993-09-10 1994-09-08 Гідрати 7-[7-(s)-аміно-5-азаспіро[2,4]гептан-5-іл]-8-хлор-6-фтор-1-[(1r,2s)-2-фторциклопропіл]-4-оксо-1,4-дигідрохінолін-3-карбонової кислоти, спосіб їх одержання і фармацевтична композиція

Country Status (32)

Country Link
US (1) US5693814A (uk)
EP (1) EP0643058B1 (uk)
JP (1) JP3793583B2 (uk)
KR (1) KR100336247B1 (uk)
CN (1) CN1057297C (uk)
AT (1) ATE181069T1 (uk)
AU (1) AU679094B2 (uk)
BG (1) BG61767B1 (uk)
CA (1) CA2131761C (uk)
CZ (3) CZ284837B6 (uk)
DE (1) DE69418953T2 (uk)
DK (1) DK0643058T3 (uk)
ES (1) ES2136142T3 (uk)
FI (1) FI110777B (uk)
GE (1) GEP19981355B (uk)
GR (1) GR3031012T3 (uk)
HR (1) HRP940506B1 (uk)
HU (1) HU224970B1 (uk)
IL (2) IL110909A (uk)
LV (1) LV11322B (uk)
MY (1) MY112574A (uk)
NO (2) NO307419B1 (uk)
NZ (1) NZ264422A (uk)
PL (1) PL180163B1 (uk)
RU (1) RU2126402C1 (uk)
SG (1) SG50492A1 (uk)
SI (1) SI9400349B (uk)
SK (3) SK283189B6 (uk)
TW (1) TW393481B (uk)
UA (1) UA41312C2 (uk)
YU (1) YU49132B (uk)
ZA (1) ZA946853B (uk)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19546249A1 (de) * 1995-12-12 1997-06-19 Bayer Ag Neue Kristallmodifikation des 1-Cyclopropyl-7-([S,S]-2,8-diazabicyclo[4,3,0]non-8-yl)-6-fluor-1,4-dihydro-8-methoxy-4-oxo-3-chinolincarbonsäure Hydrochlorid (CDCH), Verfahren zu dessen Herstellung und diese enthaltende pharmazeutische Zubereitungen
DE69802692D1 (de) 1997-06-26 2002-01-10 Dong Wha Pharm Ind Co Ltd Derivate der chinoloncarbonsäure
JP2001300293A (ja) * 2000-04-25 2001-10-30 Nipro Corp 無機無水物または有機無水物の製造法
ITMI20032259A1 (it) 2003-11-20 2005-05-21 Chemi Spa Nuovo polimorfo dell'acido 1-ciclopropil-7-(s,s-2,8-diazabciclo-4.3.0-non-8-il)-6-fluoro-1,4-diidro-8-metossi-4-oxo-chinolin carbossilico cloridrato e metodi per la sua preparazione
CN102718746B (zh) * 2012-06-18 2014-10-29 南京优科生物医药研究有限公司 西他沙星富马酸盐晶型a和其制药用途
CN103539776B (zh) * 2012-07-16 2016-06-08 深圳信立泰药业股份有限公司 一种西他沙星晶型及其制备方法
CN106749174B (zh) * 2016-12-06 2019-06-18 山东裕欣药业有限公司 一种西他沙星二水合物晶型、制备方法及其组合物片剂

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE203719C (uk) * 1907-11-02 1908-10-20
NO166131C (no) * 1985-06-20 1991-06-05 Daiichi Seiyaku Co Analogifremgangsmaate for fremstilling av s(-)-pyridobenzoksazinforbindelser.
IL90062A (en) * 1988-04-27 1994-10-07 Daiichi Seiyaku Co History of pyridonecarboxylic acid, their preparation and pharmaceutical preparations containing them
CA1332605C (en) * 1988-10-03 1994-10-18 Yasuhiro Nishitani Pyridonecarboxylic acids
TW208013B (uk) * 1990-03-01 1993-06-21 Daiichi Co Ltd
US4994809A (en) * 1990-03-07 1991-02-19 Hughes Aircraft Company Polystatic correlating radar
MY109714A (en) * 1990-10-18 1997-04-30 Daiichi Seiyaku Co Process for preparing 8-chloroquinolone derivatives
CN1065206A (zh) * 1991-04-01 1992-10-14 战永胜 天然中草药防治早泄、淋病双效药液制法
WO1993025545A1 (en) * 1992-06-09 1993-12-23 Korea Research Institute Of Chemical Technology Novel quinoline derivatives and processes for preparing the same

Also Published As

Publication number Publication date
DE69418953T2 (de) 2000-01-13
KR100336247B1 (ko) 2005-08-11
HRP940506A2 (en) 1997-04-30
NZ264422A (en) 1995-07-26
EP0643058A1 (en) 1995-03-15
PL180163B1 (pl) 2000-12-29
IL110909A0 (en) 1994-11-28
RU2126402C1 (ru) 1999-02-20
MY112574A (en) 2001-07-31
LV11322A (lv) 1996-06-20
NO992513D0 (no) 1999-05-25
US5693814A (en) 1997-12-02
YU53694A (sh) 1997-03-07
SG50492A1 (en) 1998-07-20
SK283190B6 (sk) 2003-03-04
IL110909A (en) 1998-12-06
HU9402597D0 (en) 1994-11-28
BG61767B1 (bg) 1998-05-29
PL304989A1 (en) 1995-03-20
HU224970B1 (en) 2006-04-28
JPH07126266A (ja) 1995-05-16
NO307419B1 (no) 2000-04-03
SK283189B6 (sk) 2003-03-04
CA2131761C (en) 2002-04-30
DE69418953D1 (de) 1999-07-15
EP0643058B1 (en) 1999-06-09
SI9400349A (en) 1995-04-30
CZ284738B6 (cs) 1999-02-17
BG99035A (bg) 1995-05-31
RU94032286A (ru) 1996-08-10
FI110777B (fi) 2003-03-31
NO943313D0 (no) 1994-09-08
HRP940506B1 (en) 2000-10-31
KR950008506A (ko) 1995-04-17
CZ217694A3 (en) 1995-03-15
ES2136142T3 (es) 1999-11-16
CA2131761A1 (en) 1995-03-11
JP3793583B2 (ja) 2006-07-05
TW393481B (en) 2000-06-11
LV11322B (en) 1996-10-20
SK283188B6 (sk) 2003-03-04
FI944174A0 (fi) 1994-09-09
CN1057297C (zh) 2000-10-11
ATE181069T1 (de) 1999-06-15
CZ284737B6 (cs) 1999-02-17
AU679094B2 (en) 1997-06-19
GR3031012T3 (en) 1999-12-31
YU49132B (sh) 2004-03-12
CZ284837B6 (cs) 1999-03-17
FI944174A (fi) 1995-03-11
CZ21598A3 (cs) 1999-02-17
NO992513L (no) 1995-03-13
CN1106006A (zh) 1995-08-02
AU7286294A (en) 1995-03-23
ZA946853B (en) 1995-04-24
DK0643058T3 (da) 1999-11-15
SK107694A3 (en) 1995-05-10
CZ21498A3 (cs) 1999-02-17
IL123910A (en) 1999-06-20
SI9400349B (sl) 2000-08-31
GEP19981355B (en) 1998-08-25
NO307753B1 (no) 2000-05-22
HUT68541A (en) 1995-06-28
NO943313L (no) 1995-03-13

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