UA108365C2 - Substituted bicyclic triazole derivatives as modulators of gamma sekretazy - Google Patents

Substituted bicyclic triazole derivatives as modulators of gamma sekretazy

Info

Publication number
UA108365C2
UA108365C2 UAA201207916A UAA201207916A UA108365C2 UA 108365 C2 UA108365 C2 UA 108365C2 UA A201207916 A UAA201207916 A UA A201207916A UA A201207916 A UAA201207916 A UA A201207916A UA 108365 C2 UA108365 C2 UA 108365C2
Authority
UA
Ukraine
Prior art keywords
triazole derivatives
modulators
gamma
sekretazy
compounds
Prior art date
Application number
UAA201207916A
Other languages
Russian (ru)
Ukrainian (uk)
Inventor
Клейн Мішель Анна Джозеф де
Брандт Свен Франціскус Анна ван
Хенрікус Якобус Марія Гійсен
Дідьє Жан-Клод Берзелот
Деніел Оехлріч
Original Assignee
Янссен Фармасьютікелз, Інк
Селлзом Лімітед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Янссен Фармасьютікелз, Інк, Селлзом Лімітед filed Critical Янссен Фармасьютікелз, Інк
Priority claimed from PCT/EP2011/050349 external-priority patent/WO2011086098A1/en
Publication of UA108365C2 publication Critical patent/UA108365C2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

The present invention is concerned with novel substituted bicyclie triazole derivatives of formula (I) wherein Het1, K1, R1, R2, A1, A2, A3, A4, L1, and L2 have the meaning defined in the claims The compounds according to the present invention are useful as gamma secretase modulators. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament. EMBED ISISServer (I)
UAA201207916A 2010-01-15 2011-01-12 Substituted bicyclic triazole derivatives as modulators of gamma sekretazy UA108365C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10150892 2010-01-15
PCT/EP2011/050349 WO2011086098A1 (en) 2010-01-15 2011-01-12 Novel substituted bicyclic triazole derivatives as gamma secretase modulators

Publications (1)

Publication Number Publication Date
UA108365C2 true UA108365C2 (en) 2015-04-27

Family

ID=42229172

Family Applications (2)

Application Number Title Priority Date Filing Date
UAA201207916A UA108365C2 (en) 2010-01-15 2011-01-12 Substituted bicyclic triazole derivatives as modulators of gamma sekretazy
UAA201207267A UA109776C2 (en) 2010-01-15 2011-01-12 Substituted triazole derivatives as gamma secretase modulators

Family Applications After (1)

Application Number Title Priority Date Filing Date
UAA201207267A UA109776C2 (en) 2010-01-15 2011-01-12 Substituted triazole derivatives as gamma secretase modulators

Country Status (1)

Country Link
UA (2) UA108365C2 (en)

Also Published As

Publication number Publication date
UA109776C2 (en) 2015-10-12

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