UA105278C2 - Способ получения каталитически активных антител (абзимов) с сиалидазной активностью - Google Patents

Способ получения каталитически активных антител (абзимов) с сиалидазной активностью

Info

Publication number
UA105278C2
UA105278C2 UAA201210528A UAA201210528A UA105278C2 UA 105278 C2 UA105278 C2 UA 105278C2 UA A201210528 A UAA201210528 A UA A201210528A UA A201210528 A UAA201210528 A UA A201210528A UA 105278 C2 UA105278 C2 UA 105278C2
Authority
UA
Ukraine
Prior art keywords
catalytically
active antibodies
production
sialidase activity
abzymes
Prior art date
Application number
UAA201210528A
Other languages
English (en)
Ukrainian (uk)
Inventor
Ростислав Олександрович Білий
Євгенія Євгенівна Біла
Юрій Ярославович Кіт
Original Assignee
Інститут Біології Клітини Нан України
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Інститут Біології Клітини Нан України filed Critical Інститут Біології Клітини Нан України
Priority to UAA201210528A priority Critical patent/UA105278C2/ru
Priority to PCT/IB2013/001908 priority patent/WO2014037785A2/en
Publication of UA105278C2 publication Critical patent/UA105278C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0002—Antibodies with enzymatic activity, e.g. abzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Изобретение относится к области иммунологии, клеточной биологии, клинической диагностики, биоорганической химии и может использоваться для создания каталитически активных антител с сиалидазной активностью. Согласно заявленному способу каталитически активные антитела с сиалидазной активностью получают вследствие иммунизации организма конъюгатами гаптена и высокомолекулярного (белкового) носителя, причем как гаптен используют производные ингибитора(ов) сиалидазной реакции.
UAA201210528A 2012-09-06 2012-09-06 Способ получения каталитически активных антител (абзимов) с сиалидазной активностью UA105278C2 (ru)

Priority Applications (2)

Application Number Priority Date Filing Date Title
UAA201210528A UA105278C2 (ru) 2012-09-06 2012-09-06 Способ получения каталитически активных антител (абзимов) с сиалидазной активностью
PCT/IB2013/001908 WO2014037785A2 (en) 2012-09-06 2013-09-05 Catalytic antibodies and uses thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
UAA201210528A UA105278C2 (ru) 2012-09-06 2012-09-06 Способ получения каталитически активных антител (абзимов) с сиалидазной активностью

Publications (1)

Publication Number Publication Date
UA105278C2 true UA105278C2 (ru) 2014-04-25

Family

ID=49885295

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201210528A UA105278C2 (ru) 2012-09-06 2012-09-06 Способ получения каталитически активных антител (абзимов) с сиалидазной активностью

Country Status (2)

Country Link
UA (1) UA105278C2 (ru)
WO (1) WO2014037785A2 (ru)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3478314T3 (da) * 2016-07-01 2023-06-19 Univ Leland Stanford Junior Konjugater til målrettet celleoverflade-editering
CA3087529A1 (en) 2018-01-03 2019-07-11 Palleon Pharmaceuticals Inc. Recombinant human sialidases, sialidase fusion proteins, and methods of using the same

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
JPS5896026A (ja) 1981-10-30 1983-06-07 Nippon Chemiphar Co Ltd 新規ウロキナ−ゼ誘導体およびその製造法ならびにそれを含有する血栓溶解剤
CH652145A5 (de) 1982-01-22 1985-10-31 Sandoz Ag Verfahren zur in vitro-herstellung von hybridomen welche humane monoklonale antikoerper erzeugen.
US4609546A (en) 1982-06-24 1986-09-02 Japan Chemical Research Co., Ltd. Long-acting composition
US4766106A (en) 1985-06-26 1988-08-23 Cetus Corporation Solubilization of proteins for pharmaceutical compositions using polymer conjugation
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
CA1294215C (en) 1986-10-27 1992-01-14 Ze'ev Shaked Pharmaceutical compositions of recombinant beta-interferon and formulation processes
CA1292686C (en) 1986-10-27 1991-12-03 Ze'ev Shaked Pharmaceutical compositions of recombinant interleukin-2 and formulation process
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
WO1991010448A1 (en) 1990-01-19 1991-07-25 German Cancer Research Center A cell surface antigen associated with cellular apoptosis
US5463028A (en) 1992-04-03 1995-10-31 The Trustees Of Columbia University In The City Of New York Reagents for generating a polyclonal hydrolytic antibody response against ***e and the monoclonal hydrolytic antibodies against ***e derived through these reagents
US5770208A (en) 1996-09-11 1998-06-23 Nabi Staphylococcus aureus B-linked hexosamine antigen
US6268488B1 (en) * 1999-05-25 2001-07-31 Barbas, Iii Carlos F. Prodrug activation using catalytic antibodies
FR2825154B1 (fr) * 2001-05-22 2004-01-30 Univ Compiegne Tech Composes capables de moduler l'activite et de stimuler la production d'un anticorps catalytique
EP1443963B1 (en) * 2001-10-22 2014-05-21 The Scripps Research Institute Antibody targeting compounds
US20030087435A1 (en) 2001-11-06 2003-05-08 Brandt Jeffrey J. Catalytic antibodies raised against sarin; an organophosphorous anticholinesterase, and an antigen and process for the preparation thereof
JP2005530515A (ja) 2002-06-26 2005-10-13 ユニヴァーシティー オヴ ルイスヴィル リサーチ ファウンデイション インコーポレイテッド アポトーシスの検出方法
US20060074047A1 (en) * 2004-10-06 2006-04-06 Cross Alan S Method of treating inflammation with inhibitors of sialyl transferases
JP5030961B2 (ja) 2005-10-11 2012-09-19 サーントゥル ナシオナル ドゥ ラ ルシェルシュ シャーンティフィク 細胞のアポトーシスの検出および定量化用の化合物およびキット
US20090053740A1 (en) 2005-10-31 2009-02-26 Cedars-Sinai Medical Center Agglutination-based method for fast detection, isolation and quantification of apoptotic cells

Also Published As

Publication number Publication date
WO2014037785A3 (en) 2014-05-01
WO2014037785A2 (en) 2014-03-13

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