TWM515372U - Artificial braces with sustained release dosage - Google Patents

Description

緩釋藥劑型的人工牙套Slow release drug type artificial braces

本創作係為一種人工牙套，尤指一種可填入藥劑，並且可以將藥劑暫存於牙套內部，使其能夠達到藥劑緩慢釋放功效之緩釋藥劑型的人工牙套。The present invention is an artificial braces, especially an artificial braces which can be filled with a medicament and can temporarily store the medicament in the inside of the braces so as to achieve a slow release effect of the medicament.

目前牙齒的牙周病治療方法有清除牙結石、牙根整平手術以及牙周再生手術等方法，但手術過後仍需由患者自行維護口腔衛生，一旦清潔維護失當恐導致病患口腔產生發炎反應，此時臨床醫師即會考慮投以抗生素進行進一步的消炎治療。At present, the treatment of periodontal disease of teeth has methods such as removing calculus, root leveling surgery and periodontal regeneration surgery. However, after the operation, the patient still needs to maintain oral hygiene by himself. Once the cleaning and maintenance is improper, the patient's mouth may cause an inflammatory reaction. At this point, the clinician will consider taking antibiotics for further anti-inflammatory treatment.

現有技術之抗生素投藥方式包含有：口服及局部給藥兩種方式，但這兩種給藥方式分別存在許多缺點。以口服方式進行投藥會因為給予全身性系統吸收的抗生素而影響肝腎功能導致其異常，尤其對孕婦患者而言更可能影響胎兒的健康；此外口服藥物時間不定，患者容易因為忘記服藥致使治療中斷，影響預定療效。若改以局部給藥的方式進行投藥，因為使用之抗生素藥量會被唾液稀釋，其藥效無法確定，故必須投以較大量的藥物劑量方能達到預定療效；且服藥後的短暫期間內患者不能飲食，對患者的日常生活帶來不便。The prior art antibiotic administration methods include oral administration and topical administration, but there are many disadvantages in the two administration methods. Oral administration of drugs can cause abnormalities in liver and kidney function due to the administration of antibiotics absorbed by the systemic system, especially for pregnant women, and it is more likely to affect the health of the fetus. In addition, the time of oral medication is uncertain, and patients are prone to interruption of treatment because they forget to take the medicine. Affect the intended efficacy. If the drug is administered by local administration, the amount of antibiotic used will be diluted by saliva, and the efficacy of the antibiotic will not be determined. Therefore, a larger dose of the drug must be administered to achieve the predetermined therapeutic effect; and within a short period of time after administration The patient can't eat, which is inconvenient for the patient's daily life.

另一方面，過去若是針對已裝設有牙套的患者而言，該患者可能因為齲齒或是神經抽取拔除而必須在原生牙齒的外部套設一牙套，但因該牙套的套設後若再以局部給藥的方式進行投藥，該投以之藥物難以進入原生牙齒周緣並且發揮治療功效，故僅能改以口服方式進行投藥才能達到治療的效果，但以口服方式進行投藥會對身體產生前述危害，故現有技術在齒列疾病的投藥方式上仍存在有許多問題亟待解決。On the other hand, in the past, for a patient who has a braces, the patient may have to set a braces on the outside of the original teeth because of the caries or nerve extraction, but if the braces are set, The method of local administration is to administer the drug, and the drug to be administered is difficult to enter the periphery of the original tooth and exerts therapeutic effects, so that the drug can only be administered by oral administration to achieve the therapeutic effect, but the oral administration may cause the aforementioned harm to the body. Therefore, there are still many problems in the prior art in the administration of odontoid diseases.

有鑑於現有技術的缺點及問題，現階段需要一種不會對人體產生危害，並且能夠以極少藥量即可以提供足夠的治療效果於牙齒上，減少對患者的日常生活造成的麻煩，甚至能讓套設有牙套的患者可以不需經由口服方式進行投藥即可以達到有效治療的投藥方法或裝置，讓患有齒列疾病的患者可以安全、有效地接受藥物的治療，使投予人體的藥物劑量降到最低，並且產生最大的功效。In view of the shortcomings and problems of the prior art, at this stage, there is a need for a harm to the human body, and it can provide sufficient therapeutic effect on the teeth with a small amount of medicine, thereby reducing the trouble caused to the daily life of the patient, and even allowing A patient with a braces can achieve an effective treatment method or device without administering an oral administration, so that a patient suffering from a dentition disease can safely and effectively receive the treatment of the drug, and the dosage of the drug administered to the human body. Minimize and produce maximum effectiveness.

為達到上述之創作目的，本創作所採用之技術手段為提供一種緩釋藥劑型的人工牙套，其係包括： 一套體，該套體具有一冠體以及一環側壁，所述冠體與環側壁相連結，且該環側壁相對於冠體的一側具有一套設開孔，該套設開孔的內緣凹設有一凹槽，並且由該冠體、環側壁以及套設開孔圍繞形成一容置空間於凹槽的內部； 一藥劑儲存槽，其埋設於該套體之冠體的內部； 一藥劑補給微流道，其連通套體外部以及該藥劑儲存槽；以及 至少一藥劑釋放微流道，其連通該容置空間以及藥劑儲存槽。In order to achieve the above-mentioned creative purposes, the technical means adopted by the present invention is to provide a sustained-release pharmaceutical type artificial dental sleeve, which comprises: a set body having a crown body and a ring side wall, the crown body and the ring body The side walls are connected, and the side wall of the ring has a set of openings with respect to one side of the crown, the inner edge of the sleeve is recessed with a groove, and is surrounded by the crown, the ring side wall and the sleeve opening Forming an accommodating space inside the groove; a drug storage tank embedded in the inside of the crown of the casing; a medicament supply microchannel, which communicates with the outside of the sleeve and the medicament storage tank; and at least one medicament The micro flow channel is released, which communicates with the accommodating space and the drug storage tank.

本創作之優點在於簡單利用於套體內部設有藥劑儲存槽、藥劑補給微流道以及藥劑釋放微流道等微結構，使得本創作之緩釋藥劑型的人工牙套具有暫存藥物以及緩慢釋放的功能，其能夠長時間地針對齒列的患病區域集中投藥，不但有效減少藥物用量、達到緩釋治療的功效，並且該釋放的藥物不會進入人體的其他器官，有效避免其它副作用的發生。The advantage of this creation is that it is simply used in the inside of the sleeve to have a micro-structure such as a drug storage tank, a drug supply micro-flow channel, and a drug release micro-flow channel, so that the artificial braces of the sustained release drug type of the present invention have temporary drugs and a slow release. The function of the drug can be concentrated on the diseased area of the dentition for a long time, which not only effectively reduces the dosage of the drug, but also achieves the effect of sustained release treatment, and the released drug does not enter other organs of the human body, thereby effectively avoiding other side effects. .

較佳的是，其中該環側壁的厚度由連結於冠體的一側朝向套設開孔方向逐漸遞減，並且該藥劑儲存槽由套體的冠體內進一步延伸擴大至環側壁的內部。此技術手段惟利用將藥劑儲存槽由冠體延伸擴大至環側壁的內部，使得本創作之緩釋藥劑型的人工牙套可以暫存更多的藥物，並且延長藥物釋放、治療的期間，對於無法自理口腔清潔衛生的齒列患者提供更長久的潔淨功效。Preferably, the thickness of the side wall of the ring is gradually decreased from the side connected to the crown toward the direction of the sleeve opening, and the drug storage groove is further extended from the crown of the sleeve to the inside of the side wall of the ring. The technical means only utilizes the expansion of the drug storage tank from the crown to the inside of the side wall of the ring, so that the artificial braces of the sustained release drug type of the present invention can temporarily store more drugs, and prolong the release period of the drug and the treatment, Self-care oral hygiene dentition patients provide longer-lasting cleansing benefits.

更佳的是，本創作之緩釋藥劑型的人工牙套具有至少二藥劑釋放微流道。此技術手段惟利用複數藥劑釋放微流道對齒列患者的患病區域同時進行多方投藥，藉此可以更加平均地將藥物釋放至患病區域，提升藥物對患病區域的治療效果。More preferably, the artificial braces of the sustained release dosage form of the present invention have at least two medicament release microchannels. The technical means only uses a plurality of medicaments to release the micro-flow channel to simultaneously apply the multi-dose administration to the diseased area of the dentate patient, thereby releasing the drug to the diseased area more evenly, and improving the therapeutic effect of the drug on the diseased area.

以下請配合圖式及本創作之較佳實施例，進一步闡述本創作為達成預定創作目的所採取的技術手段。In the following, please cooperate with the drawings and the preferred embodiment of the present invention to further explain the technical means adopted by the present creation for the purpose of achieving the intended creation.

如圖1及圖2所示，本創作之緩釋藥劑型的人工牙套係包括：一套體10、一藥劑儲存槽20、一藥劑補給微流道30以及複數藥劑釋放微流道40。As shown in FIG. 1 and FIG. 2, the artificial dental braces of the present invention include a set of bodies 10, a drug storage tank 20, a medicament supply microchannel 30, and a plurality of medicament release microchannels 40.

其中該套體10具有一冠體11以及一環側壁12，所述冠體11的周緣與環側壁12的頂側相連結並且一體成形，該環側壁12的厚度由環側壁12的頂側朝向底側方向逐漸遞減，並且於該環側壁12的底側具有一套設開孔13，該套設開孔13內緣形成有一朝向冠體11方向凹設的一凹槽14，並且由該冠體11、環側壁12以及套設開孔13圍繞形成一容置空間15於凹槽14內。本創作之緩釋藥劑型的人工牙套係藉由該凹槽14將人體的原生牙齒50套設於容置空間15中以進行齒列疾病的治療，如圖3及圖4所示。The sleeve body 10 has a crown body 11 and a ring side wall 12, and the circumference of the crown body 11 is coupled to the top side of the ring side wall 12 and integrally formed. The thickness of the ring side wall 12 is from the top side of the ring side wall 12 toward the bottom. The side direction is gradually decreased, and has a set of opening holes 13 on the bottom side of the side wall 12 of the ring, and the inner edge of the sleeve opening 13 is formed with a recess 14 recessed toward the crown 11 and is formed by the crown 11. The ring sidewall 12 and the sleeve opening 13 surround the recess 14 in an accommodating space 15 . The artificial braces of the sustained release drug type of the present invention are used to set the native teeth 50 of the human body in the accommodating space 15 by the grooves 14 for the treatment of odontoid diseases, as shown in FIGS. 3 and 4.

該藥劑儲存槽20主要埋設於該套體10之冠體11的內部，並且進一步由該套體10的冠體11延伸擴大至環側壁12的頂側內部，使該藥劑儲存槽20可以用於容置欲投予牙齒之藥物於套體10內部。The medicament storage tank 20 is mainly embedded in the interior of the crown 11 of the casing 10, and further extended from the crown 11 of the casing 10 to the top side of the ring sidewall 12, so that the medicament storage tank 20 can be used for The drug to be placed on the tooth is placed inside the casing 10.

該藥劑補給微流道30設置於套體10的頂側與該藥劑儲存槽20之間，該藥劑補給微流道30連通套體10外部以及該藥劑儲存槽20，使得欲投予牙齒之藥物可以從套體10外部經由該藥劑補給微流道30注射進入藥劑儲存槽20內暫存。The drug replenishing microchannel 30 is disposed between the top side of the casing 10 and the drug storage tank 20, and the drug replenishing microchannel 30 communicates with the outside of the casing 10 and the drug storage tank 20, so that the drug to be administered to the tooth is provided. The microfluidic channel 30 can be injected from the outside of the casing 10 into the drug storage tank 20 via the medicament.

所述藥劑釋放微流道40設置於套體10的凹槽14與該藥劑儲存槽20之間，所述藥劑釋放微流道40連通該藥劑儲存槽20以及容置空間15，使得暫存於藥劑儲存槽20內的欲投予牙齒之藥物可以經由藥劑釋放微流道40持續地對套設於容置空間15內的牙齒進行藥物釋放，藉此達到緩釋治療的功效。The medicament release microchannel 40 is disposed between the recess 14 of the sleeve 10 and the medicament storage tank 20, and the medicament release microchannel 40 communicates with the medicament storage tank 20 and the accommodating space 15 so as to be temporarily stored in the medicament. The drug to be administered to the teeth in the drug storage tank 20 can continuously release the drug to the teeth disposed in the accommodating space 15 via the drug releasing microchannel 40, thereby achieving the effect of the sustained release treatment.

本創作之緩釋藥劑型的人工牙套可以藉由3D列印技術，搭配醫用合成高分子材料諸如：聚甲基丙烯酸甲酯、聚乙烯、矽膠、聚酯類高分子、四氟化聚乙烯、聚胺基甲酸酯，依據不同患者、不同牙齒的形狀、尺寸需求客制化地製造成形，以3D列印技術克服緩釋藥劑型之人工牙套的複雜幾何結構與複雜微流道設計的製作困難，使得每一顆患有疾病的牙齒均可以擁有一個專屬之緩釋藥劑型的人工牙套，藉此幫助牙齒與緩釋藥劑型的人工牙套結合得更加緊密，內部的藥物不容易從原生牙齒50與牙套間的縫隙滲漏而影響治療的效果。The artificial braces of the sustained-release drug type of the present invention can be combined with medical synthetic polymer materials such as polymethyl methacrylate, polyethylene, silicone rubber, polyester polymer, and tetrafluoroethylene by 3D printing technology. Polyurethanes are custom-made according to the shape and size requirements of different patients and different teeth. The 3D printing technology is used to overcome the complex geometry of artificial braces and the design of complex microfluids. Difficult to make, each tooth with a disease can have a special artificial braces of slow release dosage form, which helps the teeth to be more tightly combined with the artificial braces of the sustained release dosage form. The internal drugs are not easy to be from the original. The gap between the tooth 50 and the mouthpiece leaks and affects the therapeutic effect.

其中冠體11的部分可以由醫用金屬材料諸如：不銹鋼、鈦金屬及其合金、鎳鉻合金做為金屬內冠，搭配醫用陶瓷材料諸如：氧化鋁、氧化鋯、玻璃陶瓷做為全瓷冠，經燒瓷冠製程將人工牙套製作成形。上述材料與人體組織、體液或血液接觸後，不會引發任何宿主免疫反應或是排斥現象，故可以安心應用於牙科醫療器材以及臨床上，供患者治療使用。The part of the crown 11 can be made of medical metal materials such as stainless steel, titanium metal and alloy thereof, nickel-chromium alloy as a metal inner crown, and medical ceramic materials such as alumina, zirconia and glass ceramics as all-ceramics. Crown, the artificial braces are formed by the porcelain crown process. When the above materials are in contact with human tissues, body fluids or blood, they do not cause any host immune response or rejection, so they can be safely applied to dental medical equipment and clinically for patient treatment.

本創作之緩釋藥劑型的人工牙套設於原生牙齒50上的實際狀態如圖4所示，該緩釋藥劑型之人工牙套的凹槽14緊密地與原生牙齒50的頂部外觀相結合固定，並且經由藥劑補給微流道30將藥劑60輸送進入藥劑儲存槽20內，再經由藥劑釋放微流道40逐漸緩慢釋放至原生牙齒50表面，藉此針對原生牙齒50進行局部的投藥，有效避免藥劑60被口中唾液稀釋而失去預定的治療功效，亦不會因為局部的投藥造成患者無法進食的不便利性。The actual state of the artificial braces of the sustained release drug type of the present invention is set on the primary tooth 50. As shown in FIG. 4, the groove 14 of the artificial braces of the sustained release dosage form is tightly fixed in combination with the top appearance of the native tooth 50. And the medicament 60 is transported into the medicament storage tank 20 via the medicament supply microchannel 30, and is gradually released to the surface of the native tooth 50 via the medicament release microchannel 40, thereby locally administering the medicament to the native tooth 50, effectively avoiding the medicament. 60 is diluted by saliva in the mouth to lose the predetermined therapeutic effect, and it is not inconvenient for the patient to eat because of local administration.

此外，本創作使得因為蛀牙嚴重或是神經抽除而必須在原生牙齒50的外部套設一牙套的牙齒亦可以接受局部的投藥，藉由本創作之緩釋藥劑型的人工牙套同時達成套設牙套與緩釋治療的雙重功效。In addition, this creation allows a tooth that must be placed over the outside of the original tooth 50 because of severe tooth decay or nerve extraction, and can also be locally administered. The artificial braces of the sustained release drug type of the present invention simultaneously achieve the set of braces. Dual efficacy with sustained release treatment.

另本創作之緩釋藥劑型的人工牙套亦可以套設於牙釘70上作為假牙使用，請參酌圖5所示，若牙齒病患嚴重到必須將原生牙齒50拔除時，牙醫一般會於原牙齦80處固定一牙釘70，該牙釘70的頂部突出於牙齦80，並且利用本創作之緩釋藥劑型的人工牙套將牙釘70的頂部套設於容置空間15中，使緩釋藥劑型之人工牙套的凹槽14與牙釘70的頂部相接合固定，形成一人工假牙。The artificial braces of the sustained-release drug type can also be set on the nail 70 as a denture. Please refer to Figure 5, if the dental patient is serious enough to remove the native tooth 50, the dentist will usually A dental nail 70 is fixed at the gum 80, and the top of the dental nail 70 protrudes from the gum 80, and the top of the dental nail 70 is sleeved in the accommodating space 15 by the artificial braces of the sustained release drug type of the present invention, so that the sustained release is performed. The groove 14 of the artificial dental mouthpiece of the pharmaceutical type is engaged with the top of the dental nail 70 to form an artificial denture.

該牙釘70同樣可以藉由緩釋藥劑型的人工牙套之藥劑儲存槽20、藥劑補給微流道30以及藥劑釋放微流道40的設置，將清潔消毒藥劑或是抗生素經由藥劑補給微流道30注入藥劑儲存槽20內暫存，再由藥劑釋放微流道40逐漸緩慢地朝向牙釘70表面釋放，藉此維持牙釘70表面的清潔，避免細菌的孳生導致周圍牙齦80發炎而引發其它口腔疾病。The dental staple 70 can also supply the cleaning and disinfecting agent or the antibiotic via the medicament to the microchannel by the drug storage tank 20 of the artificial braces of the sustained release dosage form, the drug replenishing microchannel 30, and the drug releasing microchannel 40. 30 is temporarily stored in the injecting drug storage tank 20, and then released by the medicament releasing microchannel 40 gradually toward the surface of the nail 70, thereby maintaining the surface of the nail 70 clean, avoiding bacterial growth and causing inflammation of the surrounding gum 80 and causing other Oral disease.

此外，無論本創作之緩釋藥劑型的人工牙套套設於原生牙齒50上或是牙釘70上，當藥劑60補充完成後，該藥劑補給微流道30之鄰近套體10之頂側的一端可以利用一封合劑暫時將藥劑補給微流道30封閉，避免藥劑儲存槽20內的藥劑60回流至口腔中造成患者食入，危害身體健康，亦可以避免因為藥劑60的回留損失而影響其治療或清潔的功效。In addition, regardless of the artificial braces of the sustained release drug type of the present invention, the original dental mouthpiece 50 is placed on the primary tooth 50 or the dental nail 70. When the pharmaceutical agent 60 is completed, the pharmaceutical agent supplies the microfluidic channel 30 to the top side of the adjacent casing 10. One end can temporarily close the drug replenishing microchannel 30 by using a mixture to prevent the medicament 60 in the drug storage tank 20 from flowing back into the oral cavity, causing the patient to ingest, which is harmful to the health of the body, and can also avoid the influence of the retention loss of the medicament 60. Its therapeutic or cleansing effect.

另本創作亦可以透過改變藥劑釋放微流道40的數量以及孔徑大小，進而控制藥物釋放之速度，以達到持續性地長期治療或是清潔的功效。In addition, the creation can also control the rate of drug release by changing the number of microfluidic channels 40 and the size of the pores to achieve sustained long-term treatment or cleaning.

進一步參考圖6所示，本創作之緩釋藥劑型之人工牙套的另一實施例其藥劑儲存槽20A埋設於該套體10A之冠體11A的內部，並且該藥劑儲存槽20A進一步由該套體10A的冠體11A內部延伸擴大至環側壁12A的內部，使該藥劑儲存槽20A可以用於容置欲投予牙齒之藥劑60的空間更大，可容置於套體10A內部的藥劑60量更多。此外，設置於套體10A的凹槽14A與該藥劑儲存槽20A之間的藥劑釋放微流道40A也因為藥劑儲存槽20A的加大而增設於凹槽14A與該藥劑儲存槽20A之間，使藥劑儲存槽20A內的藥劑60均可以順利經由所述藥劑釋放微流道40A流入凹槽14A中，對套設於容置空間15A內的牙齒進行藥物釋放，藉此達到緩釋治療的功效。Referring further to FIG. 6, another embodiment of the artificial braces of the sustained release drug type of the present invention has a drug storage tank 20A embedded in the interior of the crown 11A of the casing 10A, and the medicament storage tank 20A is further provided by the sleeve. The inside of the crown 11A of the body 10A extends to the inside of the ring side wall 12A, so that the drug storage tank 20A can be used to accommodate the medicine 60 to be administered to the teeth, and the medicine 60 can be accommodated inside the sleeve 10A. More quantity. In addition, the drug release microchannel 40A disposed between the recess 14A of the sleeve 10A and the drug storage tank 20A is also added between the groove 14A and the drug storage tank 20A due to the enlargement of the drug storage tank 20A. The medicament 60 in the drug storage tank 20A can be smoothly flowed into the groove 14A through the drug release microchannel 40A, and the teeth disposed in the accommodating space 15A can be released, thereby achieving the effect of sustained release treatment. .

綜上所述，本案所提供之緩釋藥劑型的人工牙套係利用套體10、10A內部之藥劑儲存槽20、20A、藥劑補給微流道30以及藥劑釋放微流道40、40A的設置，使得套設於套體10、10A之容置空間15、15A內的患病牙齒可以長時間地持續透過藥物的緩釋作用以及集中釋放達到長期治療的功效，並且藉由上述套體10、10A內部之微結構的設置，有效減少藥物用量，避免藥物浪費，甚至於治療過程中不影響全身其它器官，本創作不但適用於肝腎功能異常及孕婦等患者，更適用於無法自理口腔衛生及正確服藥之病患裝設使用。In summary, the artificial dental braces of the sustained-release drug type provided in the present invention utilize the settings of the drug storage tanks 20, 20A inside the casing 10, 10A, the drug replenishing microchannels 30, and the drug releasing microchannels 40, 40A. The diseased teeth disposed in the accommodating spaces 15, 15A of the sleeves 10, 10A can continue to pass the sustained release action of the drug and the concentrated release for a long time to achieve the long-term therapeutic effect, and by the above-mentioned sleeves 10, 10A The internal micro-structure setting effectively reduces the dosage of drugs, avoids drug waste, and even does not affect other organs in the body during treatment. This creation is not only suitable for patients with liver and kidney dysfunction and pregnant women, but also for self-care oral hygiene and proper medication. The patient is installed and used.

以上所述僅是本創作的較佳實施例而已，並非對本創作做任何形式上的限制，雖然本創作已以較佳實施例揭露如上，然而並非用以限定本創作，任何所屬技術領域中具有通常知識者，在不脫離本創作技術方案的範圍內，當可利用上述揭示的技術內容作出些許更動或修飾為等同變化的等效實施例，但凡是未脫離本創作技術方案的內容，依據本創作的技術實質對以上實施例所作的任何簡單修改、等同變化與修飾，均仍屬於本創作技術方案的範圍內。The above description is only a preferred embodiment of the present invention, and does not impose any form limitation on the present invention. Although the present invention has been disclosed above in the preferred embodiment, it is not intended to limit the present creation, and has any technical field. A person skilled in the art can make some modifications or modifications to equivalent embodiments by using the above-disclosed technical contents without departing from the technical scope of the present invention. The technical essence of the creation Any simple modification, equivalent change and modification of the above embodiments are still within the scope of the technical solution of the present invention.

10、10A‧‧‧套體
11、11A‧‧‧冠體
12、12A‧‧‧環側壁
13‧‧‧套設開孔
14、14A‧‧‧凹槽
15、15A‧‧‧容置空間
20、20A‧‧‧藥劑儲存槽
30‧‧‧藥劑補給微流道
40、40A‧‧‧藥劑釋放微流道
50‧‧‧原生牙齒
60‧‧‧藥劑
70‧‧‧牙釘
80‧‧‧牙齦10, 10A‧‧‧ body
11, 11A‧‧‧ crown
12, 12A‧‧‧ ring side wall
13‧‧‧Setting openings
14, 14A‧‧‧ Groove
15, 15A‧‧‧ accommodating space
20, 20A‧‧‧ drug storage tank
30‧‧‧ Pharmacy replenishing microchannel
40, 40A‧‧‧ Drug release microchannel
50‧‧‧ Native teeth
60‧‧‧ Pharmacy
70‧‧‧ teeth nail
80‧‧‧ teeth

圖1係本創作之緩釋藥劑型的人工牙套的立體外觀圖。 圖2係本創作之緩釋藥劑型的人工牙套的剖面圖。 圖3係本創作之緩釋藥劑型的人工牙套的套設示意圖。 圖4係本創作之緩釋藥劑型的人工牙套套設於牙齒上的示意圖。 圖5係本創作之緩釋藥劑型的人工牙套套設於牙釘上的示意圖。 圖6係本創作之緩釋藥劑型之人工牙套的另一實施例的剖面圖。Fig. 1 is a perspective view of the artificial dental mouthpiece of the sustained release drug type of the present invention. Figure 2 is a cross-sectional view of the artificial braces of the sustained release drug type of the present invention. Fig. 3 is a schematic view showing the setting of the artificial braces of the sustained release drug type of the present invention. Fig. 4 is a schematic view showing the artificial braces of the sustained release drug type of the present invention. Fig. 5 is a schematic view showing the artificial braces of the sustained release drug type of the present invention. Fig. 6 is a cross-sectional view showing another embodiment of the artificial braces of the sustained release drug type of the present invention.

10‧‧‧套體 10‧‧‧Set

11‧‧‧冠體 11‧‧‧Coron

12‧‧‧環側壁 12‧‧‧ ring side wall

13‧‧‧套設開孔 13‧‧‧Setting openings

14‧‧‧凹槽 14‧‧‧ Groove

15‧‧‧容置空間 15‧‧‧ accommodating space

20‧‧‧藥劑儲存槽 20‧‧‧Pharmaceutical storage tank

30‧‧‧藥劑補給微流道 30‧‧‧ Pharmacy replenishing microchannel

40‧‧‧藥劑釋放微流道 40‧‧‧ Drug release microchannel

60‧‧‧藥劑 60‧‧‧ Pharmacy

Claims (5)

一種緩釋藥劑型的人工牙套，其係包括： 一套體，該套體具有一冠體以及一環側壁，所述冠體與環側壁相連結，且該環側壁相對於冠體的一側具有一套設開孔，該套設開孔的內緣凹設有一凹槽，並且由該冠體、環側壁以及套設開孔圍繞形成一容置空間於凹槽的內部； 一藥劑儲存槽，其埋設於該套體之冠體的內部； 一藥劑補給微流道，其連通套體外部以及該藥劑儲存槽；以及 至少一藥劑釋放微流道，其連通該容置空間以及藥劑儲存槽。An artificial dental sleeve of a sustained-release dosage form, comprising: a set body having a crown body and a ring side wall, the crown body being coupled to the side wall of the ring, and the side wall of the ring having a side opposite to the crown body a set of openings, the inner edge of the sleeve is recessed with a recess, and the crown, the ring sidewall and the sleeve opening surround an interior of the recess; a medicament storage slot, The medicine is embedded in the interior of the crown of the casing; a medicament replenishing the microchannel, which communicates with the outside of the casing and the medicament storage tank; and at least one medicament release microchannel that communicates with the accommodating space and the drug storage tank. 如請求項1所述之緩釋藥劑型的人工牙套，其中該藥劑儲存槽由套體的冠體內進一步延伸擴大至環側壁的內部。The artificial dental mouthpiece of the sustained release dosage form according to claim 1, wherein the drug storage tank is further extended from the crown of the casing to the inside of the side wall of the ring. 如請求項1或2所述之緩釋藥劑型的人工牙套，其具有至少二藥劑釋放微流道。The artificial dental mouthpiece of the sustained release dosage form according to claim 1 or 2, which has at least two drug releasing microchannels. 如請求項1或2所述之緩釋藥劑型的人工牙套，其中該環側壁的厚度由連結於冠體的一側朝向套設開孔方向逐漸遞減。The artificial dental mouthpiece of the sustained-release dosage form according to claim 1 or 2, wherein the thickness of the side wall of the ring is gradually decreased from a side joined to the crown toward the direction of the insertion opening. 如請求項3所述之緩釋藥劑型的人工牙套，其中該環側壁的厚度由連結於冠體的一側朝向套設開孔方向逐漸遞減。The artificial dental mouthpiece of the sustained-release dosage form according to claim 3, wherein the thickness of the side wall of the ring is gradually decreased from the side joined to the crown toward the direction of the sleeve opening.