TWM467441U - Dental implant rich in calcium and phosphorus ions - Google Patents
Dental implant rich in calcium and phosphorus ions Download PDFInfo
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本創作是有關於一種富鈣磷離子的牙科植體，特別是有關於一種藉由噴砂酸蝕處理植體本體並全面性或非全面性覆蓋鈣磷酸鹽生醫陶瓷材料於本體表面之牙科植體。 This creation is about a dental implant with calcium-rich phosphorus ions, especially for a dental implant that is treated by sand blasting to treat the body of the implant and to cover the surface of the body with a comprehensive or non-universal coverage of calcium phosphate biomedical ceramic materials. body.
牙齒是人體口腔內重要組織之一，除了提供咀嚼與發音之功能外，亦會影響人們的容貌與禮儀表現。當恆牙因外傷或蛀牙被拔除之後，就不會再長出新的牙齒，因此必須做牙齒的重建。目前最常使用的方法就是在缺牙的齒槽骨上植入人工牙根(亦稱植體)，以作為假牙的支撐，因此植體本身的性質將是影響人工植牙成功與否的重要關鍵。 Teeth are one of the important tissues in the human mouth. In addition to providing the function of chewing and pronunciation, it also affects people's appearance and etiquette performance. When the permanent tooth is removed due to trauma or tooth decay, no new teeth will grow, so the reconstruction of the teeth must be done. The most commonly used method is to implant artificial roots (also called implants) on the alveolar bone of the missing teeth to support the dentures. Therefore, the nature of the implant itself will be an important factor affecting the success of artificial implants. .
鈦金屬或鈦合金係目前所使用之金屬植入物中最具有抗腐蝕性之材料，因為鈦具有良好之機械強度、化學穩定度及生物相容性，因此廣泛被應用為牙科植體之材料。有鑑於鈦金屬之生物相容性與其表面產生之氧化結構、表面型態、以及化學組成有強烈地關係。為了得到更為良好之表面特性，並可增加臨床上植體與骨組織之結合強度，發展不同之金屬表面處理方法，已成為目前牙科材料主要致力之方向。 Titanium or titanium alloy is the most corrosion-resistant material in metal implants currently used. Because titanium has good mechanical strength, chemical stability and biocompatibility, it is widely used as a material for dental implants. . In view of the fact that the biocompatibility of titanium has a strong relationship with the oxidized structure, surface morphology, and chemical composition produced on its surface. In order to obtain better surface characteristics, and to increase the bonding strength between clinical implants and bone tissue, and to develop different metal surface treatment methods, it has become the main direction of dental materials.
近年，針對使用於設計粗糙植體表面之技術，共同 之方法分別為電漿噴塗(Plasma-Spraying)、噴砂(Grit-Blasting)、酸蝕(Acid-Etching)及陽極化(Anodization)。其中，鈦電漿噴塗(Titanium Plasma-Spraying，TPS)與噴砂法係可創造三維粗糙度(Roughness)之植體表面進而改進骨頭錨定。然而，潛在有害之金屬離子溶解或微粒依然存在，例如氧化鋁，將導致局部或系統中毒效應。另一個設計粗糙植體表面方法係使用不同地強酸，例如鹽酸(HCl)或硫酸(H2SO4)，且比使用上述鈦電漿噴塗含有更一致性之微孔表面。最近，噴砂-酸蝕(Sand-blasting with large-grit and acid etching，SLA)比起使用鈦電漿噴塗(Titanium Plasma-Spraying，TPS)表面處理或酸蝕，更可引導改善早期骨整合及減少骨質流失。 In recent years, for the techniques used to design rough implant surfaces, the common methods are plasma-spraying, Grit-Blasting, Acid-Etching, and Anodization. Among them, Titanium Plasma-Spraying (TPS) and sand blasting system can create three-dimensional roughness (Roughness) of the implant surface to improve bone anchoring. However, the potentially harmful metal ion dissolution or the presence of particulates, such as alumina, will result in local or systemic poisoning effects. Another method of designing rough implant surfaces uses different strong acids, such as hydrochloric acid (HCl) or sulfuric acid (H 2 SO 4 ), and contains a more uniform microporous surface than the use of the above-described titanium plasma spray. Recently, sand-blasting with large-grit and acid etching (SLA) leads to improved early osseointegration and reduction compared to Titanium Plasma-Spraying (TPS) surface treatment or acid etching. Bone loss.
然而，傳統使用之噴砂酸蝕處理製程製得之植體，極易在植體粗糙表面上殘留氧化鋁粉末或是殘留酸蝕溶液於微孔中，而不利於骨母細胞貼附於植體上，進而影響牙齒重建之成功率。 However, the implants prepared by the conventional sand blasting treatment process are easy to leave alumina powder or residual acid etching solution on the rough surface of the implant, which is unfavorable for attaching the osteoblast to the implant. Up, and thus affect the success rate of tooth reconstruction.
有鑑於上述習知技藝之問題，本創作之一目的就是在提供一種富鈣磷離子的牙科植體，藉由覆蓋鈣磷酸鹽生醫陶瓷材料於經噴砂酸蝕處理之植體本體上，以清除噴砂酸蝕處理後殘留之氧化鋁粉末。 In view of the above-mentioned problems of the prior art, one of the aims of the present invention is to provide a calcium-phosphorus-rich dental implant by covering the calcium phosphate biomedical ceramic material on the body of the implant treated by sand blasting. The alumina powder remaining after the blasting acid etching treatment is removed.
根據本創作之另一目的，提出一種富鈣磷離子的牙科植體，藉由可釋出鈣磷離子之鈣磷酸鹽生醫陶瓷材料，可有效 中和噴砂酸蝕處理過程中之酸蝕溶液，以解決酸蝕溶液殘留於微孔中之問題。 According to another object of the present invention, a dental implant rich in calcium and phosphorus ions is proposed, which can be effectively used by a calcium phosphate biomedical ceramic material capable of releasing calcium and phosphorus ions. The acid etching solution during the blasting acid etching process is neutralized to solve the problem that the etching solution remains in the micropores.
根據本創作之又一目的，提出一種富鈣磷離子的牙科植體，藉由在遇降酸環境中會快速溶解並釋放鈣磷離子之鈣磷酸鹽生醫陶瓷材料，可提供極佳之骨引導性(osteoconduction)，有助於快速形成骨整合。 According to another object of the present invention, a calcium-phosphorus-rich dental implant is provided, which provides excellent bone by rapidly dissolving and releasing calcium phosphate ion calcium phosphate biomedical ceramic material in an acid-lowering environment. Osteoconduction helps to quickly form osseointegration.
根據本創作之再一目的，提出一種富鈣磷離子的牙科植體，顎骨之骨母細胞在鈣磷酸鹽生醫陶瓷材料降解後，可直接與植體表面接觸並產生鍵結，提高骨母細胞與植體之穩固性。 According to another object of the present invention, a dental implant with calcium-rich phosphorus ions is proposed. After degrading the calcium phosphate biomedical ceramic material, the osteoblast of the tibia can directly contact the surface of the implant and generate a bond to improve the bone mother. The stability of cells and implants.
為達前述目的，本創作提出一種富鈣磷離子的牙科植體，至少包含：一本體，本體之表面係藉由噴砂酸蝕(Sand-blasting with large-grit and acid etching，SLA)處理而具有複數個孔洞，使得本體之表面粗糙度介於1-2微米(μm)之間；以及一鈣磷酸鹽生醫陶瓷材料，全面性地或非全面性地覆蓋於本體之表面。其中，鈣磷酸鹽生醫陶瓷材料係選自於由磷酸四鈣(Ca4(PO4)2O)、二水磷酸氫鈣(CaHPO4．2H2O)、磷酸氫鈣(CaHPO4)、五水磷酸八鈣(Ca8H2(PO4)6．5H2O)、α-三鈣磷酸鹽(alpha-Ca3(PO4)2)、β-三鈣磷酸鹽(beta-Ca3(PO4)2)、焦磷酸鈣(Ca2P2O7)及二鈣磷酸鹽(Ca2H2P2O8)與其磷灰石(apatite)所組成之族群。本體之材料為鈦(Titanium)金屬或鈦合金(Titanium Alloy)。 In order to achieve the above purpose, the present invention proposes a dental implant rich in calcium and phosphorus ions, comprising at least: a body having a surface treated by sand-blasting with large-grit and acid etching (SLA) The plurality of holes are such that the surface roughness of the body is between 1-2 micrometers ( μm ); and the one calcium phosphate biomedical ceramic material covers the surface of the body in a comprehensive or non-comprehensive manner. Among them, the calcium phosphate biomedical ceramic material is selected from the group consisting of tetracalcium phosphate (Ca 4 (PO 4 ) 2 O), calcium hydrogen phosphate dihydrate (CaHPO 4 .2H 2 O), calcium hydrogen phosphate (CaHPO 4 ), Octacalcium phosphate pentahydrate (Ca 8 H 2 (PO 4 ) 6 .5H 2 O), α-tricalcium phosphate (alpha-Ca 3 (PO 4 ) 2 ), β-tricalcium phosphate (beta-Ca 3) (PO 4 ) 2 ), a group consisting of calcium pyrophosphate (Ca 2 P 2 O 7 ) and dicalcium phosphate (Ca 2 H 2 P 2 O 8 ) and its apatite. The material of the body is titanium (Titanium) or titanium alloy (Titanium Alloy).
在本創作之富鈣磷離子的牙科植體中，本體具有之孔洞之平均直徑係介於0.5-2微米(μm)之間。鈣磷酸鹽生醫陶瓷材 料之粒徑係小於20微米(μm)。鈣磷酸鹽生醫陶瓷材料覆蓋於本體之表面之厚度為10-30微米(μm)。其中，鈣磷酸鹽生醫陶瓷材料非全面性地覆蓋於本體之表面時的表面覆蓋率係介於30~70%。 In the present calcium-phosphorus-rich dental implants, the body has pores having an average diameter between 0.5 and 2 micrometers ( μm ). The particle size of the calcium phosphate biomedical ceramic material is less than 20 microns ( μm ). The calcium phosphate biomedical ceramic material covers the surface of the body to a thickness of 10-30 micrometers ( μm ). Among them, the surface coverage of the calcium phosphate biomedical ceramic material when it is non-uniformly covered on the surface of the body is between 30% and 70%.
承上所述，依本創作之富鈣磷離子的牙科植體，其可具有一或多個下述優點： As described above, the calcium-phosphorus-rich dental implants of the present invention may have one or more of the following advantages:
(1)本創作之富鈣磷離子的牙科植體，藉由覆蓋鈣磷酸鹽生醫陶瓷材料於經噴砂酸蝕處理之植體本體上，可清除噴砂酸蝕處理後殘留之氧化鋁粉末。 (1) The calcium-phosphorus-rich dental implant of the present invention can remove the residual alumina powder after the blasting acid etching treatment by covering the calcium phosphate biomedical ceramic material on the body of the blasting acid etching treatment.
(2)本創作之富鈣磷離子的牙科植體，藉由可釋出鈣磷離子之鈣磷酸鹽生醫陶瓷材料，可有效中和噴砂酸蝕處理過程中之酸蝕溶液並解決酸蝕溶液殘留於微孔中之問題。 (2) The calcium-phosphorus-ion dental implant of the present invention can effectively neutralize the acid etching solution in the blasting acid etching process and solve the acid etching by using the calcium phosphate bio-ceramic material which can release calcium and phosphorus ions. The problem of the solution remaining in the micropores.
(3)本創作之富鈣磷離子的牙科植體，藉由在遇降酸環境中會快速溶解並釋放鈣磷離子之鈣磷酸鹽生醫陶瓷材料，可提供極佳之骨引導性(osteoconduction)，有助於骨整合之快速形成。 (3) The calcium-phosphorus-incorporated dental implants of this creation provide excellent osteoinductivity by rapidly dissolving and releasing calcium phosphate ions in the acid-reducing environment. ), contributing to the rapid formation of osseointegration.
(4)本創作之富鈣磷離子的牙科植體，顎骨之骨母細胞在鈣磷酸鹽生醫陶瓷材料降解後，可直接與植體表面接觸並產生鍵結，提高骨母細胞與植體之穩固性。 (4) The dental implants of calcium and phosphorus ions in this creation, the osteoblasts of the tibia can directly contact the surface of the implant and produce bonds after degradation of the calcium phosphate biomedical ceramic material, thereby improving the osteoblasts and implants. The stability.
C1‧‧‧骨母細胞 C1‧‧‧ osteoblast
C2‧‧‧纖維母細胞 C2‧‧‧fibroblasts
C3‧‧‧表皮細胞 C3‧‧‧ epidermal cells
T‧‧‧牙齒 T‧‧‧ teeth
1‧‧‧牙科植體 1‧‧‧ Dental implants
10‧‧‧本體 10‧‧‧ Ontology
20‧‧‧鈣磷酸鹽生醫陶瓷材料 20‧‧‧Calcium phosphate biomedical ceramic materials
S100、S200‧‧‧步驟 S100, S200‧‧‧ steps
1000‧‧‧細胞 1000‧‧‧ cells
第1圖 係為應用本創作之富鈣磷離子的牙科植體於臨床試驗之剖面示意圖。 Figure 1 is a schematic cross-sectional view of a clinical application of a calcium-phosphorus-rich dental implant using the present invention.
第2A圖 係為本創作之富鈣磷離子的牙科植體之第 一較佳實施例之示意圖。 Figure 2A is the first dental implant of calcium-rich phosphorus ion A schematic diagram of a preferred embodiment.
第2B圖 係為本創作之富鈣磷離子的牙科植體之第二較佳實施例之示意圖。 Figure 2B is a schematic illustration of a second preferred embodiment of the created calcium-phosphorus-rich dental implant.
第3圖 係為本創作之富鈣磷離子的牙科植體之製作流程圖。 Figure 3 is a flow chart of the creation of a calcium-phosphorus-rich dental implant.
第4圖 係為本創作之本體經噴砂酸蝕處理以及接續以鈣磷酸鹽生醫陶瓷材料覆蓋於本體之富鈣磷離子的牙科植體表面之掃描式電子顯微鏡上視圖。 Figure 4 is a scanning electron microscope top view of the body of the creation by sandblasting and etching and the surface of the calcium-phosphorus-rich dental implant covered with calcium phosphate biomedical ceramic material.
第5圖 係為細胞於噴砂酸蝕處理之植體以及本創作之富鈣磷離子的牙科植體的貼附情形之掃描式電子顯微鏡上視圖。 Figure 5 is a scanning electron microscope top view of the attachment of cells to a sandblasted acid etched implant and a calcium-phosphorus-rich dental implant of the present invention.
第6圖 係為利用噴砂酸蝕處理以及本創作之富鈣磷離子的牙科植體進行每單位細胞之ALP分泌量的定量測試之比較圖。 Figure 6 is a comparison of quantitative tests of ALP secretion per unit cell using dental blasting treatment and the calcium-phosphorus-rich dental implants of the present invention.
第7圖 係為本創作之富鈣磷離子的牙科植體之X光繞射分析圖譜。 Figure 7 is an X-ray diffraction analysis of a dental implant of calcium-rich phosphorus ions.
請參閱第1圖，其係為應用本創作之富鈣磷離子的牙科植體於臨床試驗之剖面示意圖。如第1圖所示，本創作係將牙齒T(假牙)及牙科植體1植入於人體口腔之牙骨處，以完成人工牙根之重建。在牙科植體1植入處之細胞可分為骨母細胞C1、纖維母細胞C2以及表皮細胞C3。在牙科植體1植入口腔牙骨後， 骨母細胞C1會攤附於牙科植體1，由於牙科植體1之表面粗糙度對於骨母細胞C1攤附於牙科植體1有明顯的影響，因此，在本創作中藉由噴砂酸蝕處理之方式來提高牙科植體1之表面粗糙度。 Please refer to Fig. 1, which is a schematic cross-sectional view of a clinical application of a calcium-phosphorus-rich dental implant using the present invention. As shown in Figure 1, the creation of the tooth T (denture) and dental implant 1 is implanted in the bone of the human mouth to complete the reconstruction of the artificial root. The cells at the implant 1 of the dental implant 1 can be divided into osteoblast C1, fibroblast C2, and epidermal cell C3. After the dental implant 1 is implanted into the dental bone, The osteoblast C1 is attached to the dental implant 1. Since the surface roughness of the dental implant 1 has a significant effect on the attachment of the osteoblast C1 to the dental implant 1, it is etched by sand blasting in this creation. The manner of treatment is to improve the surface roughness of the dental implant 1.
第2A-2B圖係為第1圖中牙科植體1的表面之剖面示意圖，且第2A圖及第2B圖係分別為本創作之富鈣磷離子的牙科植體之第一較佳實施例及第二較佳實施例之示意圖。如第2A圖所示，在本創作之第一較佳實施例中，本體10之表面係藉由噴砂酸蝕處理而具有複數個孔洞，使得本體10之表面粗糙度介於1-2微米(μm)之間，且鈣磷酸鹽生醫陶瓷材料20係全面性地覆蓋於本體10之表面。如第2B圖所示，本創作之第二較佳實施例與第一較佳實施例之差異處在於，鈣磷酸鹽生醫陶瓷材料20係非全面性地覆蓋於本體10之表面。在本創作之第二較佳實施例中，鈣磷酸鹽生醫陶瓷材料20非全面性地覆蓋於本體10之表面的表面覆蓋率可例如介於30~70%。 2A-2B is a schematic cross-sectional view of the surface of the dental implant 1 in FIG. 1, and FIGS. 2A and 2B are respectively a first preferred embodiment of the created calcium-phosphorus-rich dental implant. And a schematic view of the second preferred embodiment. As shown in FIG. 2A, in the first preferred embodiment of the present invention, the surface of the body 10 has a plurality of holes by sandblasting and etching, so that the surface roughness of the body 10 is between 1-2 micrometers ( Between μ m) and the calcium phosphate biomedical ceramic material 20 is comprehensively covered on the surface of the body 10. As shown in FIG. 2B, the second preferred embodiment of the present invention differs from the first preferred embodiment in that the calcium phosphate biomedical ceramic material 20 is non-uniformly covered on the surface of the body 10. In a second preferred embodiment of the present invention, the surface coverage of the calcium phosphate biomedical ceramic material 20 that is not fully covered on the surface of the body 10 can be, for example, between 30 and 70%.
在本創作之第一較佳實施例及第二較佳實施例中，本體之材料可例如為鈦(Titanium)金屬或鈦合金(Titanium Alloy)，且本體具有之孔洞之平均直徑係例如介於0.5-2微米(μm)之間。鈣磷酸鹽生醫陶瓷材料係可例如選自於由磷酸四鈣(Ca4(PO4)2O)、二水磷酸氫鈣(CaHPO4．2H2O)、磷酸氫鈣(CaHPO4)、五水磷酸八鈣(Ca8H2(PO4)6．5H2O)、α-三鈣磷酸鹽(alpha-Ca3(PO4)2)、β-三鈣磷酸鹽(beta-Ca3(PO4)2)、焦磷酸鈣 (Ca2P2O7)及二鈣磷酸鹽(Ca2H2P2O8)與其磷灰石(apatite)所組成之族群，且鈣磷酸鹽生醫陶瓷材料之粒徑係例如小於20微米(μm)。 In the first preferred embodiment and the second preferred embodiment of the present invention, the material of the body may be, for example, a titanium (Titanium) metal or a titanium alloy (Titanium Alloy), and the average diameter of the holes of the body is, for example, Between 0.5-2 microns ( μm ). The calcium phosphate biomedical ceramic material may, for example, be selected from the group consisting of tetracalcium phosphate (Ca 4 (PO 4 ) 2 O), calcium hydrogen phosphate dihydrate (CaHPO 4 .2H 2 O), calcium hydrogen phosphate (CaHPO 4 ), Octacalcium phosphate pentahydrate (Ca 8 H 2 (PO 4 ) 6 .5H 2 O), α-tricalcium phosphate (alpha-Ca 3 (PO 4 ) 2 ), β-tricalcium phosphate (beta-Ca 3) (PO 4 ) 2 ), calcium pyrophosphate (Ca 2 P 2 O 7 ) and dicalcium phosphate (Ca 2 H 2 P 2 O 8 ) and apatite (apatite) group, and calcium phosphate The particle size of the medical ceramic material is, for example, less than 20 micrometers ( μm ).
請參閱第3圖，本創作之第一較佳實施例及第二較佳實施例之製作方式如下所述：首先，對具平滑表面之本體10進行噴砂酸蝕處理S100，使得本體10之表面具有複數個孔洞(見第4圖中之(a)圖，倍率5000倍)，且在噴砂酸蝕處理S100後，本體10之表面粗糙度可例如介於1-2微米(μm)之間；接著，在具有複數孔洞之本體10表面進行鈣磷酸鹽生醫陶瓷材料之表面處理S200，使得鈣磷酸鹽生醫陶瓷材料20覆蓋於本體10之表面(見第4圖中之(b)圖，倍率5000倍)，其中鈣磷酸鹽生醫陶瓷材料20可例如全面性地(左圖)或非全面性地(右圖)覆蓋於本體10之表面，以完成本創作之富鈣磷離子的牙科植體之第一較佳實施例或第二較佳實施例。其中，使用者可藉由調整鈣磷酸鹽生醫陶瓷材料20之噴砂或沉積的速率或時間，以決定鈣磷酸鹽生醫陶瓷材料20呈全面性地或非全面性地覆蓋於本體10表面。 Referring to FIG. 3, the first preferred embodiment and the second preferred embodiment of the present invention are manufactured as follows: First, the body 10 having a smooth surface is subjected to a sand blasting treatment S100 to make the surface of the body 10 There are a plurality of holes (see the figure (a) in Fig. 4, the magnification is 5000 times), and after the sandblasting acid etching process S100, the surface roughness of the body 10 can be, for example, between 1-2 micrometers ( μm ). Then, the surface treatment S200 of the calcium phosphate biomedical ceramic material is performed on the surface of the body 10 having a plurality of holes, so that the calcium phosphate biomedical ceramic material 20 covers the surface of the body 10 (see FIG. 4(b) , the magnification of 5000 times), wherein the calcium phosphate biomedical ceramic material 20 can cover the surface of the body 10, for example, comprehensively (left) or non-comprehensively (right) to complete the calcium-rich phosphorus ion of the present creation. A first preferred embodiment or a second preferred embodiment of a dental implant. The user can determine whether the calcium phosphate biomedical ceramic material 20 covers the surface of the body 10 in a comprehensive or non-uniform manner by adjusting the rate or time of sand blasting or deposition of the calcium phosphate biomedical ceramic material 20.
請接續參閱第5圖，其係為細胞於噴砂酸蝕處理之植體((a)圖：倍率500倍，(b)圖：倍率2000倍)以及本創作之富鈣磷離子的牙科植體((c)圖：倍率500倍，(d)圖：倍率2000倍)的貼附情形之掃描式電子顯微鏡上視圖。由於覆蓋鈣磷酸鹽生醫陶瓷材料於經噴砂酸蝕處理之植體本體上，可有效清除噴砂酸蝕處理後殘留之氧化鋁粉末並中和噴砂酸蝕處理過程中之酸蝕溶液，故有利於細胞之貼附生長。經比較第5圖中之(b)圖及(d)圖可 知，(d)圖中細胞1000可在植體表面上完全地攤附、展開，故覆蓋鈣磷酸鹽生醫陶瓷材料於經噴砂酸蝕處理之本體上可提供良好細胞1000貼附及生長之功效。 Please refer to Figure 5, which is the implanted cells treated with sandblasting acid ((a): 500 times magnification, (b): 2000 times magnification) and the calcium-phosphorus-rich dental implants. ((c) Figure: magnification of 500 times, (d): 2000 times magnification) Scanning electron microscope top view. Since the calcium phosphate biomedical ceramic material is coated on the body of the implant by sand blasting, the alumina powder remaining after the blasting acid etching treatment can be effectively removed and the acid etching solution during the blasting acid etching process is neutralized, which is advantageous Growth on the attachment of cells. After comparing (b) and (d) in Figure 5, It is known that (d) the cell 1000 can be completely spread and spread on the surface of the implant, so the cover of the calcium phosphate biomedical ceramic material can provide good cell 1000 attachment and growth effect on the body treated by sand blasting. .
續言之，在本創作之第一較佳實施例中(見第2A圖)，在牙科植體1植入人體之後，由於本體10之表面完全被鈣磷酸鹽生醫陶瓷材料20所覆蓋，因此需待鈣磷酸鹽生醫陶瓷材料20降解吸收後，顎骨之骨母細胞才可以直接跟本體10產生鍵結。而在本創作之第二較佳實施例中(見第2B圖)，由於本體10之表面並非完全被鈣磷酸鹽生醫陶瓷材料20所覆蓋，在以噴砂方式覆蓋鈣磷酸鹽生醫陶瓷材料於本體10之過程中，可有效清除殘留之氧化鋁粉末並中和酸蝕溶液，且骨母細胞能直接與本體10接觸，極有利於細胞之貼附生長。 Continuingly, in the first preferred embodiment of the present invention (see FIG. 2A), after the dental implant 1 is implanted into the human body, since the surface of the body 10 is completely covered by the calcium phosphate biomedical ceramic material 20, Therefore, after the calcium phosphate biomedical ceramic material 20 is degraded and absorbed, the osteoblast of the tibia can directly bond with the body 10. In the second preferred embodiment of the present invention (see FIG. 2B), since the surface of the body 10 is not completely covered by the calcium phosphate biomedical ceramic material 20, the calcium phosphate biomedical ceramic material is covered by sand blasting. In the process of the body 10, the residual alumina powder can be effectively removed and the acid etching solution is neutralized, and the osteoblast can directly contact the body 10, which is very advantageous for cell attachment growth.
新生骨的生成需透過骨吸收及成骨作用同時交互運行。而鹼性磷酸酶(alkaline phosphatase，ALP)是附著在成骨細胞(osteoblast)細胞膜上的醣蛋白，具有促進骨質生成的功能，因此被視為檢視成骨作用的指標性酵素。第6圖係為利用噴砂酸蝕處理以及本創作之富鈣磷離子的牙科植體進行每單位細胞之ALP分泌量的定量測試之比較圖。由第6圖可以發現，在細胞生長至21天時，本創作之每單位細胞之ALP分泌量遠高於噴砂酸蝕處理之植體，顯示經由覆蓋鈣磷酸鹽生醫陶瓷材料於經噴砂酸蝕處理之植體本體上，可提供骨細胞較佳之促進骨質生長的功能。 The formation of new bone requires simultaneous interaction through bone resorption and osteogenesis. Alkaline phosphatase (ALP) is a glycoprotein attached to the membrane of osteoblasts and has a function of promoting bone formation. Therefore, it is regarded as an indicator enzyme for examining osteogenesis. Fig. 6 is a comparison chart for quantitative test of ALP secretion per unit cell by blasting acid etching treatment and the present calcium-phosphorus-rich dental implant. It can be found from Fig. 6 that when the cells grow to 21 days, the ALP secretion per unit cell of the present creation is much higher than that of the sandblasted acid-etched implant, showing that the calcium phosphate biomedical ceramic material is coated with shale acid. The etched implant body provides a better function of bone cells to promote bone growth.
第7圖係為本創作之富鈣磷離子的牙科植體之X光 繞射分析圖譜。由第7圖可知，在入射角3°~20°之間，有明顯的鈣磷離子存在的證據(見箭頭指示處)，而在大於入射角25°時則無檢測出鈣磷離子。此外，經計算鈦的線吸收係數後可推算出鈣磷酸鹽生醫陶瓷材料覆蓋於本體之表面的厚度在10~30微米(μm)之間。 Figure 7 is the X-ray of the dental implant with calcium and phosphorus ions. Diffraction analysis map. It can be seen from Fig. 7 that there is evidence of the presence of significant calcium and phosphorus ions between the incident angles of 3° and 20° (see the arrow indication), and no calcium and phosphorus ions are detected at 25° above the incident angle. In addition, after calculating the linear absorption coefficient of titanium, it can be inferred that the thickness of the calcium phosphate biomedical ceramic material covering the surface of the body is between 10 and 30 micrometers (μm).
習知以氫氧基磷灰石電漿噴塗(HA Coating)於植體表面以形成疏鬆粗糙表面，其塗層厚度約為50μm。氫氧基磷灰石(Hydroxyapatite，HA)之化學式為Ca10(PO4)6(OH)2，屬接近天然骨成分的鈣磷酸鹽陶瓷材料，生物相容性佳，生物吸收率低，因此類表面處理方式僅為氫氧基磷灰石材料與金屬材料之植體的結合，又顎骨細胞直接與氫氧基磷灰石材料產生鍵結，在齒科植體植入人體5~10年後，可能會發生塗層與金屬材料之間剝離的現象，最終導致植牙的失敗。 It is conventional to apply HA coating on the surface of the implant to form a loose and rough surface having a coating thickness of about 50 μm . Hydroxyapatite (HA) has a chemical formula of Ca 10 (PO 4 ) 6 (OH) 2 , which is a calcium phosphate ceramic material close to natural bone components. It has good biocompatibility and low bioabsorption rate. The surface treatment method is only the combination of the hydroxyapatite material and the metal material implant, and the tibia cells directly bond with the hydroxyapatite material, and implant the dental implant in the human body for 5-10 years. After that, peeling between the coating and the metal material may occur, eventually leading to failure of the implant.
由於本創作中鈣磷酸鹽生醫陶瓷材料為一種具生物相容性之材質，與氫氧基磷灰石的鈣磷比、密度及結構都十分相似，但由於鈣磷酸鹽生醫陶瓷材料具有高度的生物可相容性，且鈣磷酸鹽生醫陶瓷材料在遇降酸環境時會快速溶解鈣磷離子，可提供骨整合時所需之鈣離子及磷酸根離子，擁有極佳之骨引導性。此外，由於本創作並非以陶瓷材料長期存在於顎骨與金屬材料之間，而是在鈣磷酸鹽生醫陶瓷材料降解後，顎骨細胞可直接與植體表面產生鍵結，因此，並不會發生類似氫氧基磷灰石塗層剝離而導致植牙失敗之情形，故可提高骨質與植體接觸率 (bone-to-implant contact，BIC)，有效提升骨整合效率。 Because the calcium phosphate biomedical ceramic material in this creation is a biocompatible material, the ratio of calcium to phosphorus and density and structure of the hydroxyapatite are very similar, but the calcium phosphate biomedical ceramic material has High biocompatibility, and calcium phosphate biomedical ceramic materials dissolve calcium and phosphorus ions rapidly in the acid-reducing environment, providing calcium and phosphate ions for osseointegration, and excellent bone guidance Sex. In addition, since this creation does not exist in the ceramic material for a long time between the tibia and the metal material, but after the degradation of the calcium phosphate biomedical ceramic material, the tibia cells can directly bond with the surface of the implant, so it does not occur. Similar to the case where the hydroxyapatite coating is peeled off and the dental implant fails, so the bone and implant contact rate can be improved. (bone-to-implant contact, BIC), effectively improve the efficiency of osseointegration.
以上所述僅為舉例性，而非為限制性者。任何未脫離本創作之精神與範疇，而對其進行之等效修改或變更，均應包含於後附之申請專利範圍中。 The above is intended to be illustrative only and not limiting. Any equivalent modifications or alterations to the spirit and scope of this creation shall be included in the scope of the appended patent application.
1‧‧‧牙科植體 1‧‧‧ Dental implants
10‧‧‧本體 10‧‧‧ Ontology
20‧‧‧鈣磷酸鹽生醫陶瓷材料 20‧‧‧Calcium phosphate biomedical ceramic materials
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