TWI685294B - A securing device - Google Patents

A securing device Download PDF

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Publication number
TWI685294B
TWI685294B TW107145978A TW107145978A TWI685294B TW I685294 B TWI685294 B TW I685294B TW 107145978 A TW107145978 A TW 107145978A TW 107145978 A TW107145978 A TW 107145978A TW I685294 B TWI685294 B TW I685294B
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cover body
experimental animal
joint portion
tail
present
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TW107145978A
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Chinese (zh)
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TW202023363A (en
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張世霖
蕭雅文
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張世霖
蕭雅文
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Priority to TW107145978A priority Critical patent/TWI685294B/en
Priority to CN201922272563.7U priority patent/CN212186764U/en
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Publication of TW202023363A publication Critical patent/TW202023363A/en

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Abstract

本發明提供一種保定裝置，其包括一底座與一蓋體。該底座設有一第一結合部。該蓋體具有至少一腔室，供容置一實驗動物，該蓋體具有一鄰近實驗動物頭部之頭端以及一鄰近實驗動物尾部的尾端，該蓋體設有至少一第二結合部，供以磁力的方式與該第一結合部結合。 The invention provides a Baoding device, which comprises a base and a cover. The base is provided with a first coupling part. The cover body has at least one chamber for accommodating an experimental animal, the cover body has a head end adjacent to the head of the experimental animal and a tail end adjacent to the tail of the experimental animal, and the cover body is provided with at least one second joint portion , For magnetically coupling with the first coupling portion.

Description

保定裝置 Baoding device

本發明關於一種保定裝置，特別是一種用於一般動物實驗中之實驗動物之保定裝置，其以磁力的方式將實驗動物有效固定且設有窗口與加熱裝置，該窗口讓實驗人員可以有效地從實驗動物的各個部位抽取血液、採集組織與注射藥物等；該加熱裝置會讓實驗動物之體溫升高進而使血管變得明顯以便於實驗人員進行實驗操作。 The invention relates to a Baoding device, especially a Baoding device for experimental animals in general animal experiments. It effectively fixes experimental animals in a magnetic manner and is provided with a window and a heating device. The window allows the experimenter to effectively Blood is drawn from various parts of the experimental animal, tissues are collected, and medicines are injected. The heating device will increase the temperature of the experimental animal and make the blood vessels obvious to facilitate the experimental operation.

一般來說，實驗動物是一種經由人工繁殖、運用遺傳工程技術製造出動物而具有特定遺傳資訊且生產過程經過人為精密控制而用於特定醫藥、生技產品之生產或實驗的動物。現今生技、醫藥領域投入大量資源於動物實驗之研究，以藉由實驗動物對藥物或外來物理或化學刺激如：病菌、特定藥物或特定外在環境等引發之生理及藥理作用，有效預測哺乳動物於相同藥物或刺激下所產生之反應而作為醫院體系臨床治療之基礎。 Generally speaking, an experimental animal is an animal produced by artificial breeding and using genetic engineering technology with specific genetic information and the production process is controlled by human precision and used for the production or experiment of specific medicines and biotechnological products. Nowadays, a large amount of resources are invested in the research of animal experiments in the fields of biotechnology and medicine, so as to effectively predict the physiological and pharmacological effects caused by experimental animals on drugs or external physical or chemical stimuli such as: bacteria, specific drugs or specific external environments. The response of animals under the same drugs or stimuli is used as the basis for clinical treatment in the hospital system.

評估實驗動物在針對前述病菌、特定藥物或特定外在環境等引發之生理及藥理作用所回應之整體生理狀況的方式大體區分為清醒模式(conscious model)以及麻醉模式(anesthetic model)。前述清醒模式係利用餵食管餵食(Oral gavage)、皮下注射(Subcutaneous,SC)、腹腔注射(Intraperitoneal,IP)、肌肉注射(Intramuscular,IM)以及靜脈注射(Intravenous,IV)等方式給藥，或以電擊、冷熱或特定環境等方式刺激實 驗動物來觀察其反應。另一方面，麻醉模式動物實驗法是將實驗動物灌注、吸入或施打麻醉劑後，固定至平台上進行簡單手術後進行各種生理測試如腦波、心跳或血壓等，再經由人為採樣或儀器監控藥物或特定環境條件對動物體產生的生理與藥理反應。 The methods for evaluating the overall physiological conditions of experimental animals in response to the physiological and pharmacological effects caused by the aforementioned pathogens, specific drugs, or specific external environments are broadly divided into a conscious model and an anesthetic model. The aforementioned awake mode is administered by feeding tube (Oral gavage), subcutaneous injection (Subcutaneous, SC), intraperitoneal injection (IP), intramuscular injection (Intramuscular, IM), and intravenous injection (Intravenous, IV), etc., or Stimulate real life by means of electric shock, hot or cold Animal testing to observe its response. On the other hand, the animal experiment method of anesthesia mode is to infuse, inhale or administer anesthesia to the experimental animal, fix it to the platform and perform various physiological tests such as brain wave, heartbeat or blood pressure after simple surgery, and then monitor it by artificial sampling or instrument Physiological and pharmacological reactions of drugs or specific environmental conditions on animals.

在清醒模式或麻醉模式進行動物實驗的過程中，若實驗設計中有包括前述對實驗動進行物強迫性步驟且其神智清醒或辦清醒的狀態下，則須將實驗動物關入保定裝置內以便於實驗操作。然而，實驗動物本身是活體狀態而保定裝置的固定效果不夠，因此，習知技術有採用壓板而能夠壓住實驗動物之身體；或，將魔鬼粘以及配合該魔鬼粘相互對應的絨毛部或勾扣部設置於手術平台之周圍，如此一來，實驗者能夠將實驗動物置於該手術平台上且利用該魔鬼粘所對應的絨毛部及勾扣部固定實驗動物之四肢，以將該實驗動物以趴臥的姿勢固定在手術平台上；或，習知技術中圓筒型態之盒體在實驗操作時，經驗藥物注射之實驗動物欲實施二次注射時，往往會頑強抵抗拒絕鑽入圓筒型態之盒體或於盒內不安躁動造成二次注射之困難。換言之，更進一步而言，在實驗動物往往要進行多次注射或採樣等動作的條件下，前述所及習知技術中所採用之壓板、四肢固定或圓桶型態的盒體皆會讓實驗人員難以有效一次固定實驗動物體而導致耗時沒有效率。此外，無論是對實驗動物進行臉頰採血(Submandibular or facial vein)、隱靜脈採血(Saphenous vein)、尾靜脈採血(Tail vein)、眼窩採血(Orbital sinus)、心臟採血(Cardiac puncture)，若實驗動物沒有被固定好，都有可能採集失敗甚至對實驗動物產生危險且有可能要重複多次，因此，前述習知的固定方式顯然需改進。 During the animal experiment in the awake mode or anesthesia mode, if the experimental design includes the aforementioned compulsory steps for the experimental animal and its mental state is sober or sober, the experimental animal must be closed into the Baoding device in order to For experimental operation. However, the experimental animal itself is in a living state and the fixing effect of the fixation device is not enough. Therefore, the conventional technology has the use of a pressure plate to be able to press the body of the experimental animal; or, the devil and the fluff or hook corresponding to the devil can be glued to each other The buckle part is arranged around the surgical platform, so that the experimenter can place the experimental animal on the surgical platform and fix the limbs of the experimental animal with the villi and hook parts corresponding to the devil's glue, so that the experimental animal It is fixed on the surgical platform in a prone position; or, in the conventional technology, when the cylindrical box body is experimentally operated, the experimental animal with experimental drug injection will often resist the refusal to enter the circle The barrel-shaped box or the restlessness in the box causes difficulty in the second injection. In other words, furthermore, under the condition that experimental animals often have to perform multiple injections or samplings, the pressure plate, limbs fixed, or drum-shaped box used in the above-mentioned conventional techniques will make the experiment It is difficult for personnel to effectively fix the experimental animal body at one time, resulting in time-consuming and inefficient. In addition, no matter whether it is a submandibular or facial vein, Saphenous vein, Tail vein, Orbital sinus, Cardiac puncture, if the experimental animal If it is not fixed, the collection may fail or even be dangerous to the experimental animals and may be repeated multiple times. Therefore, the aforementioned conventional fixing method obviously needs to be improved.

因此，亟需提供一種讓實驗動物能有效固定至定位且操作簡單而利於各種實驗有效實施之保定裝置已刻不容緩；並為了克服前述習知技術所產生之問題，遂有本發明的產生。 Therefore, there is an urgent need to provide a Baoding device that allows laboratory animals to be effectively fixed to position and is simple to operate and facilitate the effective implementation of various experiments. In order to overcome the problems caused by the aforementioned conventional technologies, the invention has been produced.

本發明之目的是提供一種保定裝置，藉由磁力將保定裝置之蓋體與底座加以穩固結合，以達到結合力不僅強且可以依照實驗動物的種類調整磁力的大小之技術效果，而不用設置如習知技術般對實驗動物四肢固定或在保定裝置中設置其他複雜的固定元件或結構，構造簡單、方便製作且成本低廉；藉由分段式的加熱片裝置，而可針對實驗動物不同的身體面(部位)進行加溫，而讓實驗人員可以有效進採血、靜脈注射等實驗；藉由在蓋體上設有不同窗口，讓實驗人員便於針對不同身體部位進行實驗而實驗動物本身可以保持穩固。 The purpose of the present invention is to provide a Baoding device, which securely combines the lid and the base of the Baoding device with magnetic force, so as to achieve the technical effect that the binding force is not only strong and the size of the magnetic force can be adjusted according to the type of experimental animal, without setting such as Conventional technology is generally used to fix the limbs of experimental animals or other complicated fixing elements or structures in the Baoding device. The structure is simple, convenient to manufacture and low in cost; with a segmented heating device, it can target different bodies of experimental animals Heating of the face (parts), so that the experimenter can effectively enter blood collection, intravenous injection and other experiments; by providing different windows on the cover, the experimenter can easily conduct experiments on different body parts and the experimental animal itself can be kept stable .

為達前述目的，本發明提供一種保定裝置，其包括一底座與一蓋體。該底座設有一第一結合部。該蓋體具有至少一腔室，供容置一實驗動物，該蓋體具有一鄰近實驗動物頭部之頭端以及一鄰近實驗動物尾部的尾端，該蓋體設有至少一第二結合部，供以磁力的方式與該第一結合部結合。 To achieve the foregoing objective, the present invention provides a Baoding device, which includes a base and a cover. The base is provided with a first coupling part. The cover body has at least one chamber for accommodating an experimental animal, the cover body has a head end adjacent to the head of the experimental animal and a tail end adjacent to the tail of the experimental animal, and the cover body is provided with at least one second joint portion , For magnetically coupling with the first coupling portion.

在一實施例中，其中，該蓋體之該頭端形成一通氣孔，該蓋體之該尾端形成一開口，供固定實驗動物之尾部。 In one embodiment, the head end of the cover body forms a vent hole, and the tail end of the cover body forms an opening for fixing the tail of the experimental animal.

在一實施例中，其中該蓋體具有一底緣，該底緣包括至少一對互相平行的邊，該至少一對互相平行的邊分別延伸形成一延伸部，供分別設置該至少一第二結合部。 In an embodiment, wherein the cover has a bottom edge, the bottom edge includes at least one pair of mutually parallel sides, and the at least one pair of mutually parallel sides respectively extend to form an extension portion for respectively providing the at least one second side combination.

在一實施例中，其中該蓋體具有一底緣，該第二結合部係設於該底緣上。 In an embodiment, the cover has a bottom edge, and the second coupling portion is disposed on the bottom edge.

在一實施例中，其中該蓋體具有一內表面，且該第二結合部是設於該內表面上。 In an embodiment, the cover has an inner surface, and the second coupling portion is disposed on the inner surface.

在另一實施例中，其中該第一結合部與該第二結合部中至少一者係為磁鐵或電磁鐵裝置。 In another embodiment, at least one of the first coupling portion and the second coupling portion is a magnet or an electromagnet device.

在一實施例中，其中該蓋體形成有至少一操作窗口。 In an embodiment, the cover body is formed with at least one operation window.

在一實施例中，其中該腔室之內表面是設有一第一加熱件。 In an embodiment, the inner surface of the chamber is provided with a first heating element.

在一實施例中，其中該底座之上表面是設有一第二加熱件。 In an embodiment, the upper surface of the base is provided with a second heating element.

為對於本發明之特點與作用能有更深入之瞭解，茲藉實施配合圖式詳述於後。 In order to have a more in-depth understanding of the features and functions of the present invention, the implementation coordination diagram is described in detail below.

1‧‧‧底座 1‧‧‧Base

2‧‧‧蓋體 2‧‧‧cover

3‧‧‧第一結合部 3‧‧‧First Joint Department

4‧‧‧第二結合部 4‧‧‧The second joint

5‧‧‧第一加熱件 5‧‧‧The first heating element

6‧‧‧第二加熱件 6‧‧‧Second heating element

7‧‧‧電源 7‧‧‧Power

11‧‧‧上表面 11‧‧‧Upper surface

21‧‧‧通氣孔 21‧‧‧vent

22‧‧‧開口 22‧‧‧ opening

23‧‧‧底緣 23‧‧‧Bottom edge

24、24’‧‧‧邊 24, 24’‧‧‧ side

241、242‧‧‧延伸部 241, 242‧‧‧ Extension

25‧‧‧內表面 25‧‧‧Inner surface

26‧‧‧窗口 26‧‧‧window

A‧‧‧頭端 A‧‧‧Head

B‧‧‧尾端 B‧‧‧End

a‧‧‧腔室 a‧‧‧Chamber

第1圖係為本發明之保定裝置之實施例之結構示意圖。 Figure 1 is a schematic structural view of an embodiment of the Baoding device of the present invention.

第2圖係為本發明之保定裝置之實施例之使用狀態示意圖。 FIG. 2 is a schematic view of the use state of an embodiment of the Baoding device of the present invention.

第3圖係為本發明之保定裝置之實施例之使用狀態示意圖。 FIG. 3 is a schematic view of the use state of an embodiment of the Baoding device of the present invention.

第4圖係為本發明之保定裝置之實施例之使用狀態示意圖之前視圖。 Fig. 4 is a front view of a schematic view of the use state of an embodiment of the Baoding device of the present invention.

第5圖係為本發明之保定裝置之另一實施例之使用狀態示意圖之前視圖。 FIG. 5 is a front view of a schematic view of the use state of another embodiment of the Baoding device of the present invention.

第6圖係為本發明之保定裝置之另一實施例之使用狀態示意圖之前視圖。 FIG. 6 is a front view of a schematic view of the use state of another embodiment of the Baoding device of the present invention.

第7圖是為本發明二氧化氯水溶液生產系統之實施例之混合 槽41的結構圖。 Figure 7 is a mixture of an embodiment of the chlorine dioxide aqueous solution production system of the present invention Block 41 structure diagram.

第8圖係為本發明之保定裝置之另一實施例之結構示意圖。 FIG. 8 is a schematic structural view of another embodiment of the Baoding device of the present invention.

第9A圖係為將小鼠以本發明之保定裝置固定且經該第一加熱件5與該第二加熱件6加熱後之小鼠尾巴之照片。 FIG. 9A is a photograph of the tail of the mouse after the mouse is fixed by the Baoding device of the present invention and heated by the first heating element 5 and the second heating element 6.

第9B圖係為將小鼠以本發明之保定裝置固定且經該第一加熱件5與該第二加熱件6加熱後之小鼠體溫隨加熱時間變化之長條圖。 FIG. 9B is a bar graph showing the change of the body temperature of the mouse with the heating time after the mouse is fixed by the Baoding device of the present invention and heated by the first heating element 5 and the second heating element 6.

為對於本發明之特點與作用能有更深入之瞭解，茲藉實施例配合圖式詳述於後，各圖中相同之符號是表示相同或等同的元件。 In order to have a more in-depth understanding of the features and functions of the present invention, the embodiments and figures are used to describe in detail below. The same symbols in the figures represent the same or equivalent elements.

請參考本發明之第1圖，本發明之保定裝置之一實施例包括：一底座1與一蓋體2。該底座1設有一第一結合部3。該蓋體2具有至少一腔室a供容置一實驗動物，該實驗動物可為一般動物實驗所用之大鼠、小鼠等中、小型哺乳動物。在另一實施例中，本發明之保定裝置亦可應用在大型的動物，但磁力的部分需依照實驗動物之力量做相對調整，描述如後。 Please refer to FIG. 1 of the present invention. An embodiment of the Baoding device of the present invention includes: a base 1 and a cover 2. The base 1 is provided with a first coupling part 3. The cover 2 has at least one chamber a for accommodating an experimental animal. The experimental animal may be a small or medium-sized mammal such as a rat or a mouse used for general animal experiments. In another embodiment, the Baoding device of the present invention can also be applied to large animals, but the magnetic force part needs to be relatively adjusted according to the strength of the experimental animal, as described later.

再，該蓋體2設有至少一第二結合部4，而該第二結合部4是與該第一結合部3以磁力的方式相結合。在本發明之保定裝置之實施例中，該第一結合部3與該第二結合部4具有永久或非永久磁性。例如，該第一結合部3與該第二結合部是包括：鐵、鋼、鎳、鈷及其化合物與合金等。在另一實施例中，該第一結合部3及第二結合部4之磁性可由磁性材料如磁鐵或電磁鐵裝置產生。由此可知，如前所述，該第一結合部3與該第二結合部4是具有永久或非永久磁性。因此，本發明如此般之設置即可維持於該底座1 與該蓋體2間之穩固結合力。若需要針對小型哺乳動物給予較強的磁力之條件下，可將該第一結合部3與該第二結合部4皆設有一強力磁鐵，製程極為簡單。若需要可即時調整之磁力，則可將該第一結合部3與該第二結合部4中至少一者設有電磁鐵裝置。換言之，本發明亦可有效利用電磁鐵裝置的特性即時調整該底座1與該蓋體2間所需磁力。 Furthermore, the cover 2 is provided with at least one second coupling portion 4, and the second coupling portion 4 is magnetically coupled with the first coupling portion 3. In an embodiment of the Baoding device of the present invention, the first coupling portion 3 and the second coupling portion 4 have permanent or non-permanent magnetism. For example, the first joint portion 3 and the second joint portion include: iron, steel, nickel, cobalt, and their compounds and alloys. In another embodiment, the magnetic properties of the first coupling portion 3 and the second coupling portion 4 can be generated by magnetic materials such as magnets or electromagnet devices. It can be seen that, as described above, the first coupling portion 3 and the second coupling portion 4 have permanent or non-permanent magnetism. Therefore, the present invention can be maintained on the base 1 in such a configuration Strong binding force with the cover 2. If a strong magnetic force needs to be given to a small mammal, a strong magnet can be provided for both the first coupling part 3 and the second coupling part 4, and the manufacturing process is extremely simple. If a magnetic force that can be adjusted in real time is required, at least one of the first coupling portion 3 and the second coupling portion 4 may be provided with an electromagnet device. In other words, the present invention can also effectively utilize the characteristics of the electromagnet device to adjust the required magnetic force between the base 1 and the cover 2 in real time.

請繼續參考第1圖，該蓋體2具有一鄰近實驗動物頭部之頭端A以及一鄰近實驗動物尾部的尾端B，其中該頭端A形成有一通氣孔21，該尾端B形成有一開口22而供固定實驗動物之尾部，而分別供實驗動物呼吸以及便於實驗人員抽取實驗動物之尾靜派的血。 Please continue to refer to FIG. 1, the cover 2 has a head end A adjacent to the head of the experimental animal and a tail end B adjacent to the tail of the experimental animal, wherein the head end A is formed with a vent hole 21 and the tail end B is formed with a The opening 22 is used for fixing the tail of the experimental animal, and is used for breathing of the experimental animal and for the laboratory staff to draw the blood of the experimental animal's tail.

請參考第1、2、4圖，在一實施例中，該蓋體2具有一底緣23，該底緣23包括至少一對互相平行的邊24、24’，該至少一對互相平行的邊24、24’分別延伸形成一延伸部241、242而供分別設置該第二結合部4，於本實施例中，四個該第二結合部是定位在鄰近該蓋體2之四角之延伸部241、242上以加強該蓋體2與該座體1間磁力吸附的效果。在另一實施例中，也可以不同的數量之第二結合部且其被定位在該等延伸部241、242之其他部分，藉以針對不同的實驗動物之個別情況作調整。 Please refer to FIGS. 1, 2, and 4, in one embodiment, the cover 2 has a bottom edge 23, the bottom edge 23 includes at least a pair of mutually parallel sides 24, 24', the at least one pair of mutually parallel The edges 24, 24' respectively extend to form an extension portion 241, 242 for providing the second coupling portion 4, respectively. In this embodiment, four of the second coupling portions are positioned adjacent to the four corners of the cover 2 to extend The portions 241 and 242 are used to enhance the effect of magnetic attraction between the cover 2 and the base 1. In another embodiment, different numbers of second joints may also be positioned at other parts of the extensions 241, 242, so as to adjust to the individual conditions of different experimental animals.

本發明之該蓋體2形成有至少一操作窗口。請參考第3圖，於一實施例中，該蓋體2之側邊、上方可各設有一窗口26，若實驗人員需要對實驗動物的特定部位如後腦、腹背、四肢等進行特定實驗，例如，臉頰採血、隱靜脈採血、尾靜脈採血、眼窩採血、心臟採血、腹腔注射、肌肉注射、皮下注射、靜脈注射、餵食管餵食等，即可將該等窗口26打開，對於實驗動物之特定部位進行前述實驗操作，而實驗動物仍能穩固的被固定在 本發明之保定裝置中不會亂動以便實驗的進行。請參考第8圖，於另一實施例中，本發明之該蓋體更設有一可滑動式之操作窗口26。換言之，本發明之該窗口26亦可有不同的設計變化。 The cover 2 of the present invention is formed with at least one operation window. Please refer to FIG. 3, in an embodiment, a window 26 may be provided on each side and above the cover 2, if the experimenter needs to perform specific experiments on specific parts of the experimental animal such as the hind brain, ventral back, and limbs, for example , Cheek blood collection, saphenous blood collection, tail vein blood collection, eye socket blood collection, heart blood collection, intraperitoneal injection, intramuscular injection, subcutaneous injection, intravenous injection, feeding tube feeding, etc., you can open these windows 26 for specific parts of laboratory animals Carry out the aforementioned experimental operations, and the experimental animals can still be firmly fixed in The Baoding device of the present invention will not be disturbed to facilitate the experiment. Please refer to FIG. 8. In another embodiment, the cover of the present invention is further provided with a sliding operation window 26. In other words, the window 26 of the present invention can also have different design changes.

請參考第5圖，在本發明之保定裝置之另一實施例中，該蓋體2具有一底緣23，且該第二結合部4是設於該底緣23之至少一部份。如此設置的優點是讓該蓋體2之整體更為簡潔，與前述實施例相比，該第二結合部4所設置的磁鐵則需要是強力磁鐵或電磁鐵裝置等，以在較小的接觸面上仍有足以讓實驗動物無法逃脫的磁力。 Please refer to FIG. 5. In another embodiment of the Baoding device of the present invention, the cover 2 has a bottom edge 23, and the second coupling portion 4 is provided on at least a part of the bottom edge 23. The advantage of this arrangement is to make the entire body of the cover 2 more concise. Compared with the previous embodiment, the magnet provided in the second joint 4 needs to be a strong magnet or an electromagnet device, etc. There is still enough magnetic force on the surface for the experimental animals to escape.

請參考第6圖，在本發明之保定裝置之另一實施例中，該蓋體2具有一內表面25，且該第二結合部4是設於該內表面25。如此設置之原因在於以強力磁鐵或電磁鐵裝置之側面之磁力即足以產生讓實驗動物無法逃脫之磁力。在另一實施例中，本發明之蓋體2也可為不同的形狀如第7圖所示之拱形等，而該第二結合部4是設於該底緣23或該底緣23之一部份。 Please refer to FIG. 6. In another embodiment of the Baoding device of the present invention, the cover 2 has an inner surface 25, and the second coupling portion 4 is provided on the inner surface 25. The reason for this setting is that the magnetic force on the side of the strong magnet or electromagnet device is enough to generate the magnetic force that the experimental animal cannot escape. In another embodiment, the cover body 2 of the present invention may also have different shapes such as an arch shape shown in FIG. 7, and the second joint portion 4 is provided on the bottom edge 23 or the bottom edge 23 a part.

在一實施例中，請參考本發明之1、2、4、5、6圖，本發明之該腔室a之該內表面25是設有一第一加熱件5，經由開啟一電源7而啟動該第一加熱件而供實驗動物在實驗進行的過程中能因著適宜的加溫而維持活力，也讓實驗動物四肢的血管適宜的擴張。該底座2之一上表面11下是設有一第二加熱件6，而該第一結合部3設於該上表面11上，同樣的也能讓實驗動物在實驗進行的過程中能因著適宜的加溫而維持活力。在另一實施例中，該第二加熱件6亦可設於該上表面11上，而該第一結合部3設於該上表面11下。在另一實施例中，可用分段通電的方式讓該腔室a之內表面與該底座之上表面中至少一者通電，以因應實驗動物需要加溫的各種需求且節省 能源。在另一實施例中，請參考第1圖，該腔室a之內表面之左、右、頂部之加熱片是可為獨立通電之加熱片。例如，當需要對實驗動物之右前肢進行處理時，只需要將右側之加熱片通電即可而不用全部的加熱片皆通電，以達節省能源之技術效果。請參考本發明之第9A圖，其係為將小鼠以本發明之保定裝置固定且經該第一加熱件5與該第二加熱件6加熱3分鐘、6分鐘後之小鼠尾巴之照片，與加熱前相比，小鼠之尾靜脈隨著時間增加有越來越明顯的趨勢，以便實驗人員下針。請參考本發明之第9B圖，係為將6隻小鼠以本發明之保定裝置固定且經該第一加熱件5與該第二加熱件6加熱0、3、6、9、12分鐘之小鼠體溫(測量肛溫)隨加熱時間變化之長條圖，由實驗結果發現，經加熱3、6、9、12分鐘之小鼠體溫與未加熱之小鼠體溫之變化有顯著差異(t-test；3分鐘：p<0.05；6、9、12分鐘：p<0.001)。由實驗結果可知，本發明之保定裝置顯然可以讓實驗動物之體溫升高、血液循環增加而導致血管變的明顯，以便讓實驗人員方便進行實驗所需的步驟。 In an embodiment, please refer to figures 1, 2, 4, 5, and 6 of the present invention. The inner surface 25 of the chamber a of the present invention is provided with a first heating element 5, which is activated by turning on a power supply 7 The first heating element is for the experimental animal to maintain vitality due to appropriate heating during the experiment, and also allows the blood vessels of the experimental animal's limbs to expand appropriately. A second heating element 6 is provided under one of the upper surfaces 11 of the base 2 and the first coupling portion 3 is provided on the upper surface 11, which also allows the experimental animals to be suitable during the experiment Heating up and maintaining vitality. In another embodiment, the second heating element 6 can also be disposed on the upper surface 11, and the first coupling portion 3 can be disposed under the upper surface 11. In another embodiment, at least one of the inner surface of the chamber a and the upper surface of the base can be electrified by means of segmented energization, in order to meet the various needs of laboratory animals for heating and save energy. In another embodiment, please refer to FIG. 1, the left, right, and top heating plates on the inner surface of the chamber a are heating plates that can be independently energized. For example, when it is necessary to treat the right forelimb of an experimental animal, it is only necessary to energize the heater on the right without using all the heaters to achieve the technical effect of saving energy. Please refer to FIG. 9A of the present invention, which is a photograph of a mouse tail which is fixed with the Baoding device of the present invention and heated by the first heating element 5 and the second heating element 3 for 3 minutes and 6 minutes Compared with before heating, the tail vein of the mouse has a more and more obvious trend with the increase of time, so that the experimenter can lower the needle. Please refer to Figure 9B of the present invention, which is to fix 6 mice with the Baoding device of the present invention and heat the first heating element 5 and the second heating element 6 for 0, 3, 6, 9, 12 minutes A bar graph of the change of mouse body temperature (measured anal temperature) with heating time. From the experimental results, it is found that there is a significant difference between the body temperature of mice heated for 3, 6, 9, and 12 minutes and the body temperature of unheated mice (t -test; 3 minutes: p<0.05; 6, 9, 12 minutes: p<0.001). From the experimental results, it can be seen that the Baoding device of the present invention can obviously increase the body temperature and blood circulation of the experimental animal and cause the blood vessels to become obvious, so that the experimenter can conveniently carry out the steps required for the experiment.

因此，本發明具有以下之優點： Therefore, the present invention has the following advantages:

1.本發明利用磁鐵之穩固磁力或能調整磁力大小之電磁鐵裝置而有效針對各種不同類型的實驗動物之力量進行調整，結構簡單、製程方便不用如習知的壓板、四肢固定或圓桶型態的盒體般結構複雜。 1. The present invention utilizes the stable magnetic force of a magnet or an electromagnet device capable of adjusting the size of the magnetic force to effectively adjust the strength of various types of experimental animals. The structure is simple and the manufacturing process is convenient without the conventional pressure plate, fixed limbs or barrel type The structure of the box is complicated.

2.本發明之加熱片是可因應不同的實驗調整其通電加熱的部分，而對實驗動物之個身體部位加熱，不僅節省能源且能讓特定的身體部位之血管擴張，方便實驗人員之採血等步驟更便利。 2. The heating sheet of the present invention can adjust its energized heating according to different experiments, and heat the body parts of the experimental animals, which not only saves energy but also allows the blood vessels of specific body parts to expand, which is convenient for the blood sampling of the experimenters, etc. The steps are more convenient.

3.實驗人員可藉由本發明所設置的各窗口對實驗動物進行各種實驗處理，極為便利且不用其他裝置加以固定。 3. The experimenter can perform various experimental treatments on experimental animals through the windows provided by the present invention, which is extremely convenient and does not need to be fixed by other devices.

以上所述乃是本發明之具體實施例及所運用之技術手段，根據本文的揭露或教導可衍生推導出許多的變更與修正，若依本發明之構想所作之等效改變，其所產生之作用仍未超出說明書及圖式所涵蓋之實質精神時，均應視為在本發明之技術範疇之內，合先陳明。 The above are the specific embodiments of the present invention and the technical means used. Many changes and modifications can be derived based on the disclosure or teachings of this article. If equivalent changes are made according to the concept of the present invention, the resulting When the effect still does not exceed the essential spirit covered by the specification and drawings, it should be deemed to be within the technical scope of the present invention and shall be stated in advance.

依上文所揭示之內容，本發明確可達到發明之預期目的，提供一種保定裝置，具有產業利用與實用之價值無疑，爰依法提出發明專利申請。 According to the content disclosed above, the present invention can indeed achieve the intended purpose of the invention, provide a Baoding device, which is undoubtedly of industrial use and practical value, and file a patent application for invention according to law.

1‧‧‧底座 1‧‧‧Base

2‧‧‧蓋體 2‧‧‧cover

3‧‧‧第一結合部 3‧‧‧First Joint Department

4‧‧‧第二結合部 4‧‧‧The second joint

5‧‧‧第一加熱件 5‧‧‧The first heating element

6‧‧‧第二加熱件 6‧‧‧Second heating element

7‧‧‧電源 7‧‧‧Power

11‧‧‧上表面 11‧‧‧Upper surface

21‧‧‧通氣孔 21‧‧‧vent

22‧‧‧開口 22‧‧‧ opening

24、24’‧‧‧邊 24, 24’‧‧‧ side

241、242‧‧‧延伸部 241, 242‧‧‧ Extension

25‧‧‧內表面 25‧‧‧Inner surface

A‧‧‧頭端 A‧‧‧Head

B‧‧‧尾端 B‧‧‧End

a‧‧‧腔室 a‧‧‧Chamber

Claims (8)

一種保定裝置，其包括：一底座，其設有一第一結合部；一蓋體，其具有至少一腔室，供容置一實驗動物，該蓋體具有一鄰近實驗動物頭部之頭端以及一鄰近實驗動物尾部的尾端，該蓋體設有至少一第二結合部，供以磁力的方式與該第一結合部結合；其中該蓋體具有一底緣，該底緣包括至少一對互相平行的邊，該至少一對互相平行的邊分別延伸形成一延伸部，供分別設置該至少一第二結合部。 A fixing device, comprising: a base, which is provided with a first joint portion; a cover body, which has at least one cavity for accommodating an experimental animal, the cover body has a head end adjacent to the head of the experimental animal, and A tail end adjacent to the tail of the laboratory animal, the cover body is provided with at least a second coupling portion for magnetically coupling with the first coupling portion; wherein the cover body has a bottom edge, and the bottom edge includes at least one pair For the mutually parallel sides, the at least one pair of mutually parallel sides respectively extend to form an extending portion for respectively providing the at least one second joint portion. 一種保定裝置，其包括：一底座，其設有一第一結合部；一蓋體，其具有至少一腔室，供容置一實驗動物，該蓋體具有一鄰近實驗動物頭部之頭端以及一鄰近實驗動物尾部的尾端，該蓋體設有至少一第二結合部，供以磁力的方式與該第一結合部結合；其中該蓋體具有一底緣，且該第二結合部是設於該底緣上。 A fixing device, comprising: a base, which is provided with a first joint portion; a cover body, which has at least one cavity for accommodating an experimental animal, the cover body has a head end adjacent to the head of the experimental animal, and A tail end adjacent to the tail of the laboratory animal, the cover body is provided with at least a second joint portion for magnetically coupling with the first joint portion; wherein the cover body has a bottom edge, and the second joint portion is Set on the bottom edge. 一種保定裝置，其包括：一底座，其設有一第一結合部；一蓋體，其具有至少一腔室，供容置一實驗動物，該蓋體具有一鄰近實驗動物頭部之頭端以及一鄰近實驗動物尾部的尾端，該蓋體設有至少一第二結合部，供以磁力的方式與該第一結合部結合；其中該蓋體具有一內表面，該第二結合部是設於該內表面上。 A fixing device, comprising: a base, which is provided with a first joint portion; a cover body, which has at least one cavity for accommodating an experimental animal, the cover body has a head end adjacent to the head of the experimental animal, and A tail end adjacent to the tail of the experimental animal, the cover body is provided with at least a second joint portion for magnetically coupling with the first joint portion; wherein the cover body has an inner surface, and the second joint portion is provided On the inner surface. 如申請專利範圍第1、2或3項所述之保定裝置，其中，該蓋體之該頭端形成一通氣孔，該蓋體之該尾端形成一開口，供固定實驗動物之尾部。 The Baoding device as described in item 1, 2 or 3 of the patent application scope, wherein the head end of the cover body forms a vent hole, and the tail end of the cover body forms an opening for fixing the tail of the laboratory animal. 如申請專利範圍第1、2或3項所述之保定裝置，其中該第一結合部與該第二結合部中至少一者係為磁鐵或電磁鐵裝置。 The Baoding device as described in item 1, 2 or 3 of the patent application scope, wherein at least one of the first coupling part and the second coupling part is a magnet or an electromagnet device. 如申請專利範圍第1、2或3項所述之保定裝置，其中該蓋體形成有至少一操作窗口。 The Baoding device as described in item 1, 2 or 3 of the patent application scope, wherein the cover body is formed with at least one operation window. 如申請專利範圍第1、2或3項所述之保定裝置，其中該腔室之內表面是設有一第一加熱件。 The Baoding device as described in item 1, 2 or 3 of the patent application scope, wherein the inner surface of the chamber is provided with a first heating element. 如申請專利範圍第1、2或3項所述之保定裝置，其中該底座之上表面是設有一第二加熱件。 The Baoding device as described in item 1, 2 or 3 of the patent application scope, wherein a second heating element is provided on the upper surface of the base.
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JP2016192920A (en) * 2015-03-31 2016-11-17 国立大学法人徳島大学 Limb fixture for animal, and limb fixing method for animal
CN105662636A (en) * 2016-03-10 2016-06-15 苏州大学 Device for animal tail vein injection
JP2018064944A (en) * 2016-10-18 2018-04-26 尚英 笠原 Electrode device for laboratory animal electrocardiogram
TWM577649U (en) * 2018-12-19 2019-05-11 張世霖 Restraint device

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