TWI672489B - 用於微粒子分選之光源模組 - Google Patents

用於微粒子分選之光源模組 Download PDF

Info

Publication number
TWI672489B
TWI672489B TW105134721A TW105134721A TWI672489B TW I672489 B TWI672489 B TW I672489B TW 105134721 A TW105134721 A TW 105134721A TW 105134721 A TW105134721 A TW 105134721A TW I672489 B TWI672489 B TW I672489B
Authority
TW
Taiwan
Prior art keywords
light source
light
source module
unit
patterned
Prior art date
Application number
TW105134721A
Other languages
English (en)
Other versions
TW201816381A (zh
Inventor
吳宏偉
洪政源
葉昌鑫
Original Assignee
統創科技股份有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 統創科技股份有限公司 filed Critical 統創科技股份有限公司
Priority to TW105134721A priority Critical patent/TWI672489B/zh
Priority to US15/491,993 priority patent/US10569282B2/en
Priority to CN201710299716.XA priority patent/CN108012366B/zh
Publication of TW201816381A publication Critical patent/TW201816381A/zh
Application granted granted Critical
Publication of TWI672489B publication Critical patent/TWI672489B/zh

Links

Classifications

    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05B—ELECTRIC HEATING; ELECTRIC LIGHT SOURCES NOT OTHERWISE PROVIDED FOR; CIRCUIT ARRANGEMENTS FOR ELECTRIC LIGHT SOURCES, IN GENERAL
    • H05B45/00—Circuit arrangements for operating light-emitting diodes [LED]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C5/00—Separating dispersed particles from liquids by electrostatic effect
    • B03C5/02—Separators
    • B03C5/022—Non-uniform field separators
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F21—LIGHTING
    • F21V—FUNCTIONAL FEATURES OR DETAILS OF LIGHTING DEVICES OR SYSTEMS THEREOF; STRUCTURAL COMBINATIONS OF LIGHTING DEVICES WITH OTHER ARTICLES, NOT OTHERWISE PROVIDED FOR
    • F21V14/00—Controlling the distribution of the light emitted by adjustment of elements
    • F21V14/04—Controlling the distribution of the light emitted by adjustment of elements by movement of reflectors
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F21—LIGHTING
    • F21V—FUNCTIONAL FEATURES OR DETAILS OF LIGHTING DEVICES OR SYSTEMS THEREOF; STRUCTURAL COMBINATIONS OF LIGHTING DEVICES WITH OTHER ARTICLES, NOT OTHERWISE PROVIDED FOR
    • F21V17/00—Fastening of component parts of lighting devices, e.g. shades, globes, refractors, reflectors, filters, screens, grids or protective cages
    • F21V17/10—Fastening of component parts of lighting devices, e.g. shades, globes, refractors, reflectors, filters, screens, grids or protective cages characterised by specific fastening means or way of fastening
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F21—LIGHTING
    • F21V—FUNCTIONAL FEATURES OR DETAILS OF LIGHTING DEVICES OR SYSTEMS THEREOF; STRUCTURAL COMBINATIONS OF LIGHTING DEVICES WITH OTHER ARTICLES, NOT OTHERWISE PROVIDED FOR
    • F21V5/00—Refractors for light sources
    • F21V5/04—Refractors for light sources of lens shape
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F21—LIGHTING
    • F21V—FUNCTIONAL FEATURES OR DETAILS OF LIGHTING DEVICES OR SYSTEMS THEREOF; STRUCTURAL COMBINATIONS OF LIGHTING DEVICES WITH OTHER ARTICLES, NOT OTHERWISE PROVIDED FOR
    • F21V7/00—Reflectors for light sources
    • F21V7/0083—Array of reflectors for a cluster of light sources, e.g. arrangement of multiple light sources in one plane
    • G—PHYSICS
    • G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
    • G09G—ARRANGEMENTS OR CIRCUITS FOR CONTROL OF INDICATING DEVICES USING STATIC MEANS TO PRESENT VARIABLE INFORMATION
    • G09G3/00—Control arrangements or circuits, of interest only in connection with visual indicators other than cathode-ray tubes
    • G09G3/001—Control arrangements or circuits, of interest only in connection with visual indicators other than cathode-ray tubes using specific devices not provided for in groups G09G3/02 - G09G3/36, e.g. using an intermediate record carrier such as a film slide; Projection systems; Display of non-alphanumerical information, solely or in combination with alphanumerical information, e.g. digital display on projected diapositive as background
    • G09G3/002—Control arrangements or circuits, of interest only in connection with visual indicators other than cathode-ray tubes using specific devices not provided for in groups G09G3/02 - G09G3/36, e.g. using an intermediate record carrier such as a film slide; Projection systems; Display of non-alphanumerical information, solely or in combination with alphanumerical information, e.g. digital display on projected diapositive as background to project the image of a two-dimensional display, such as an array of light emitting or modulating elements or a CRT
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0652—Sorting or classification of particles or molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0654—Lenses; Optical fibres
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0424—Dielectrophoretic forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0454—Moving fluids with specific forces or mechanical means specific forces radiation pressure, optical tweezers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C5/00—Separating dispersed particles from liquids by electrostatic effect
    • B03C5/005—Dielectrophoresis, i.e. dielectric particles migrating towards the region of highest field strength
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/02—Investigating particle size or size distribution
    • G01N15/0266—Investigating particle size or size distribution with electrical classification
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B27/00—Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00
    • G02B27/0018—Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00 with means for preventing ghost images

Landscapes

  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Fluid Mechanics (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Theoretical Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Computer Hardware Design (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

一種用於微粒子分選之光源模組，包含發光元件、控制單元和光轉換單元。發光元件用以產生光源。控制單元用以依據圖像資料產生驅動訊號。光轉換單元耦接控制單元，其用以依據驅動訊號將光源轉換為圖案化光源，且其光出射度介於9萬勒克斯與12萬勒克斯之間。圖案化光源為黑白圖案化光源，其對比度介於1000比1與150000比1之間。

Description

用於微粒子分選之光源模組
本發明是有關於一種用於微粒子分選之光源模組，且特別是一種用於利用光誘發介電泳(light-induced dielectrophoresis；LIDEP)原理進行微粒子分選之光源模組。
醫學檢驗係利用各種醫學分析儀器來進行微粒子或分子的分析，並以分析結果來輔助生物體生理狀態的評估。若僅需對單一微粒子進行分析，則需先將包含不同微粒子的流體進行分選。近年來已有應用光誘發介電泳原理來分選微粒子的技術，然而，晶片設計、操作環境和光源等因素均會影響光誘發介電泳原理進行微粒子分選的效果。
本發明的目的是在於提供一種光源模組，其適用於利用光誘發介電泳原理進行的微粒子分選並可分選出具高純度的微粒子。
根據本發明之上述目的，提出一種用於微粒子分選之光源模組，此光源模組包含發光元件、控制單元和光轉換單元。發光元件用以產生光源。控制單元用以依據圖像 資料產生驅動訊號。光轉換單元耦接控制單元，其用以依據驅動訊號將光源轉換為圖案化光源，且其光出射度介於9萬勒克斯(lux)與12萬勒克斯之間，其中圖案化光源為黑白圖案化光源，其對比值(contrast ratio)介於1000比1與150000比1之間。
依據本發明的一實施例，上述發光元件包含白光發光二極體，且上述光源為可見光源。
依據本發明的又一實施例，上述圖案化光源的波長介於280奈米(nm)與1400奈米之間。
依據本發明的又一實施例，上述光轉換單元包含一數位微型反射鏡元件(digital micromirror device；DMD)。
依據本發明的又一實施例，上述光源模組更包含通訊單元，其耦接至控制單元用以與計算機設備通訊連接並從計算機設備接收圖像資料。
依據本發明的又一實施例，上述光源模組更包含透鏡單元和連結單元。透鏡單元用以調整圖案化光源的平面尺寸。連結單元具有相對的第一端及第二端，其第一端位於光轉換單元的出光側，且其第二端用以容置透鏡單元。
依據本發明的又一實施例，上述連結單元為可伸縮的筒狀結構。
依據本發明的又一實施例，上述連結單元的最大延伸長度約為30公分。
依據本發明的又一實施例，上述圖案化光源的聚焦成像範圍介於10公分與50公分之間。
100‧‧‧分選裝置
110、200、300、400‧‧‧光源模組
120‧‧‧光誘發介電泳晶片
120A‧‧‧投射區域
210、310、410‧‧‧發光元件
220、320、420‧‧‧控制單元
230、330、430‧‧‧光轉換單元
340‧‧‧通訊單元
440‧‧‧透鏡單元
450‧‧‧連接單元
F‧‧‧流體
L‧‧‧長度
P1‧‧‧第一微粒子
P2‧‧‧第二微粒子
PC‧‧‧計算機設備
為了更完整了解實施例及其優點，現參照結合所附圖式所做之下列描述，其中：〔圖1〕繪示分選裝置的示意圖；〔圖2〕繪示依據本發明一些實施例之光源模組的示意圖；〔圖3〕繪示依據本發明另一些實施例之光源模組的示意圖；以及〔圖4〕繪示依據本發明又一些實施例之光源模組的示意圖。
以下仔細討論本發明的實施例。然而，可以理解的是，實施例提供許多可應用的概念，其可實施於各式各樣的特定內容中。所討論、揭示之實施例僅供說明，並非用以限定本發明之範圍。
請參照圖1，圖1繪示分選裝置100的示意圖。分選裝置100包含光源模組110和光誘發介電泳晶片120。光源模組110用以產生圖案化光源，而光誘發介電泳晶片120用以在受到圖案化光源的照射下對不同微粒子進行分選處理。圖案化光源可以是彩色圖案化光源或黑白圖案化光源，其對比值(contrast ratio)介於1000比1與150000比1之間。在本文中，微粒子可以是生物細胞、空氣微粒、 水中雜質或介電粉末等。舉例而言，若將包含第一微粒子P1和第二微粒子P2的流體F注入至光誘發介電泳晶片120中，則光誘發介電泳晶片120可藉由圖案化光源的影響而在其投射區域120A中產生非均勻電場，以在光誘發介電泳晶片120上產生高低電阻差，使得第一微粒子P1和第二微粒子P2的表面累積不同密度的表面電荷，從而受到不同的介電泳力(dielectrophoresis force；DEP force)作用而移動至不同處。如此一來，流體F中的第一微粒子P1和第二微粒子P2可被光誘發介電泳晶片120分選出。
圖2繪示依據本發明一些實施例之光源模組200的示意圖。光源模組200可以是例如圖1之光源模組110，其包含發光元件210、控制單元220和光轉換單元230。發光元件210用以產生光源，其可以是例如燈泡、發光二極體或激光器等，但不限於此。舉例而言，發光元件210可以是發光二極體，其用以發射出包含可見光波長的光源。控制單元220用以依據圖像資料產生驅動訊號，且將驅動訊號傳輸至光轉換單元230，使得光轉換單元230據以將發光元件210發射出的光源轉換為圖案化光源。為了使微粒子分選達到最佳效果，光轉換單元230的光出射度(luminous exitance)可介於9萬勒克斯(lux)與12萬勒克斯之間，且其產生之圖案化光源的波長範圍可介於280奈米與1400奈米之間。光轉換單元230可包含數位微型反射鏡元件(digital micromirror device；DMD)或矽基液晶(liquid crystal on silicon；LCoS)元件，其可依據驅 動訊號來決定輸出的圖案化光源，此圖案化光源的解析度和發光色彩可分別為1920畫素×1080畫素和16百萬色(16.7百萬色或16.2百萬色)，但不限於此。舉例而言，在一些實施例中，光轉換單元230產生之圖案化光源的可以是640畫素×480畫素和黑白256色。此外，在另外一些實施例中，光轉換單元230產生的圖案化光源為類比光源。另一方面，圖像資料可以是對應動態圖像的資料，使得光轉換單元230根據驅動訊號動態調整圖案化光源。
圖3繪示依據本發明另一些實施例之光源模組300的示意圖。光源模組300可以是例如圖1之光源模組110，其包含發光元件310、控制單元320、光轉換單元330和通訊單元340。光源模組300與圖2之光源模組200的差別在於，光源模組300更包含通訊單元340，其用以與計算機設備PC通訊連接且從計算機設備PC接收圖像資料。詳細而言，通訊單元340可使用有線通訊(例如VGA、HDMI、eDP、USB等)或無線通訊(例如WiFi、藍牙等)方式通訊連接計算機設備PC，且計算機設備PC傳輸圖像資料至通訊單元340，接著控制單元320再依據接收到的圖像資料產生驅動訊號，且將驅動訊號傳輸至光轉換單元330，使得光轉換單元330據以將發光元件210發射出的光源轉換為圖案化光源。發光元件310和光轉換單元330分別與圖2之發光元件210和光轉換單元230相似，故相關說明請參照先前段落，在此不贅述。
圖4繪示依據本發明又一些實施例之光源模組400的示意圖。光源模組400可以是例如圖1之光源模組110，其包含發光元件410、控制單元420、光轉換單元430、透鏡單元440和連結單元450。光源模組400與圖2之光源模組200的差別在於，光源模組400更包含透鏡單元440和連結單元450，其中透鏡單元440用以調整光轉換單元430所發射出圖案化光源的平面尺寸，而連結單元450為筒狀結構，其第一端位於光轉換單元430的出光側，且其第二端容置透鏡單元440。透鏡單元440的調整倍率可以是1/4倍至1/2倍，但不限於此。連結單元450可以是可伸縮的筒狀結構，其可用以延伸物距，以縮短光源模組400的投影距離，並可避免圖案化光源外散而造成光損失。藉由透鏡單元440和連結單元450的設置，圖案化光源的聚焦成像範圍可介於10公分與50公分之間。進一步地，圖案化光源的聚焦成像範圍較佳為大約20公分。在一些實施例中，連結單元450的最大延伸長度約為30公分。發光元件410和光轉換單元430分別與圖2之發光元件210和光轉換單元230相似。此外，光源模組400另可包含通訊單元(圖4未繪示)，且此通訊單元(圖4未繪示)和控制單元420分別與通訊單元340和控制單元320相似。因此，有關發光元件410、控制單元420和光轉換單元430之說明請參照先前段落，在此不贅述。
透過本發明之光源模組產生的圖案化光源，可準確改變光誘發介電泳晶片的內部電場，進而分選出具高純 度的微粒子。因此，本發明之光源模組適合用於生物和醫學領域之應用，例如生化處理和檢驗醫學等。
雖然本發明已以實施例揭露如上，然其並非用以限定本發明，任何所屬技術領域中具有通常知識者，在不脫離本發明的精神和範圍內，當可作些許的更動與潤飾，故本發明的保護範圍當視後附的申請專利範圍所界定者為準。

Claims (7)

  1. 一種用於微粒子分選之光源模組，包含：一發光元件，用以產生一光源；一控制單元，用以依據一圖像資料產生一驅動訊號；一光轉換單元，耦接至該控制單元，該光轉換單元用以依據該驅動訊號將該光源轉換為一圖案化光源，且其光出射度(luminous exitance)介於9萬勒克斯(lux)與12萬勒克斯之間，其中該圖案化光源係一黑白圖案化光源，其對比值(contrast ratio)介於1000比1與150000比1之間；一透鏡單元，用以調整該圖案化光源之一平面尺寸；以及一連結單元，具有相對之一第一端及第二端，該第一端位於該光轉換單元之一出光側，且該第二端用以容置該透鏡單元，其中該連結單元係一可伸縮之筒狀結構。
  2. 如申請專利範圍第1項所述之光源模組，其中該發光元件包含一白光發光二極體，且該光源係一可見光源。
  3. 如申請專利範圍第1項所述之光源模組，其中該圖案化光源之波長介於280奈米(nm)與1400奈米之間。
  4. 如申請專利範圍第1項所述之光源模組，其中該光轉換單元包含一數位微型反射鏡元件(digital micromirror device；DMD)。
  5. 如申請專利範圍第1項所述之光源模組，更包含：一通訊單元，耦接至該控制單元，該通訊單元用以與一計算機設備通訊連接且從該計算機設備接收該圖像資料。
  6. 如申請專利範圍第1項所述之光源模組，其中該連結單元之一最大延伸長度約為30公分。
  7. 如申請專利範圍第1項所述之光源模組，其中該圖案化光源之一聚焦成像範圍介於10公分與50公分之間。
TW105134721A 2016-10-27 2016-10-27 用於微粒子分選之光源模組 TWI672489B (zh)

Priority Applications (3)

Application Number Priority Date Filing Date Title
TW105134721A TWI672489B (zh) 2016-10-27 2016-10-27 用於微粒子分選之光源模組
US15/491,993 US10569282B2 (en) 2016-10-27 2017-04-20 Light source module and microparticles sorting apparatus having the same
CN201710299716.XA CN108012366B (zh) 2016-10-27 2017-05-02 用于微粒子分选的光源模块

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
TW105134721A TWI672489B (zh) 2016-10-27 2016-10-27 用於微粒子分選之光源模組

Publications (2)

Publication Number Publication Date
TW201816381A TW201816381A (zh) 2018-05-01
TWI672489B true TWI672489B (zh) 2019-09-21

Family

ID=62020858

Family Applications (1)

Application Number Title Priority Date Filing Date
TW105134721A TWI672489B (zh) 2016-10-27 2016-10-27 用於微粒子分選之光源模組

Country Status (3)

Country Link
US (1) US10569282B2 (zh)
CN (1) CN108012366B (zh)
TW (1) TWI672489B (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11835441B2 (en) 2020-11-20 2023-12-05 Industrial Technology Research Institute Sample classification device, sample classification system, and sample classification method

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102449163A (zh) * 2009-04-03 2012-05-09 加利福尼亚大学董事会 分选细胞和其它生物微粒的方法和装置
USRE44711E1 (en) * 2004-04-12 2014-01-21 The Regents Of The University Of California Optoelectronic tweezers for microparticle and cell manipulation

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101109592B1 (ko) * 2005-04-25 2012-01-31 삼성전자주식회사 광원 모듈 및 이를 채용한 화상투사장치
JP4422074B2 (ja) 2005-06-16 2010-02-24 Ｎｅｃディスプレイソリューションズ株式会社 プロジェクタおよびフォーカス調整方法
JP5549459B2 (ja) * 2010-07-23 2014-07-16 船井電機株式会社 画像表示装置
US9332236B2 (en) 2011-03-03 2016-05-03 Nec Display Solutions, Ltd. Image projection apparatus and method of controlling light source
JP5948837B2 (ja) * 2011-03-29 2016-07-06 ソニー株式会社 固体撮像素子及び電子機器
JP5356463B2 (ja) * 2011-07-21 2013-12-04 富士フイルム株式会社 ノズル面洗浄装置および液滴吐出装置
US9323039B2 (en) 2012-11-06 2016-04-26 Industrial Technology Research Institute Particle manipulation system and projection device
CN103855142B (zh) * 2012-12-04 2017-12-29 东芝照明技术株式会社 发光装置及照明装置
US10089415B2 (en) * 2013-12-19 2018-10-02 Faro Technologies, Inc. Three-dimensional coordinate scanner and method of operation
US9343443B2 (en) * 2014-02-05 2016-05-17 Cooledge Lighting, Inc. Light-emitting dies incorporating wavelength-conversion materials and related methods
CN105202444A (zh) * 2014-06-26 2015-12-30 中强光电股份有限公司 车用照明装置

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE44711E1 (en) * 2004-04-12 2014-01-21 The Regents Of The University Of California Optoelectronic tweezers for microparticle and cell manipulation
CN102449163A (zh) * 2009-04-03 2012-05-09 加利福尼亚大学董事会 分选细胞和其它生物微粒的方法和装置

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
U *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11835441B2 (en) 2020-11-20 2023-12-05 Industrial Technology Research Institute Sample classification device, sample classification system, and sample classification method

Also Published As

Publication number Publication date
US20180117599A1 (en) 2018-05-03
CN108012366A (zh) 2018-05-08
US10569282B2 (en) 2020-02-25
CN108012366B (zh) 2019-10-11
TW201816381A (zh) 2018-05-01

Similar Documents

Publication Publication Date Title
US11328380B2 (en) Machine vision systems, illumination sources for use in machine vision systems, and components for use in the illumination sources
CN105976725B (zh) 微发光二极管显示面板
US10175110B2 (en) Portable hyperspectral camera apparatus having semiconductor light emitting devices
JP2018028683A (ja) 顕微撮像法
KR20200018501A (ko) 적어도 하나의 대상체의 위치를 결정하는 검출기
CN104285442B (zh) 用于可携带的图像投影仪的具有双色激光二极管的激光模块
JP2024052855A (ja) 光学検査装置、方法及びプログラム
TWI672489B (zh) 用於微粒子分選之光源模組
Bosse et al. Open LED illuminator: a simple and inexpensive LED illuminator for fast multicolor particle tracking in neurons
TW201816379A (zh) 生物分選系統及其方法
JP7341145B2 (ja) 皮膚を画像化する装置
Cerpentier et al. Adaptive museum lighting using cnn-based image segmentation
Kuo et al. Optical design of an LED lighting source for fluorescence microscopes
US10668469B2 (en) Biological sorting apparatus and method thereof
CN209928125U (zh) 一种用于显微物镜阵列的集成化光源装置
TW201833544A (zh) 光誘發介電泳晶片、微粒子分選裝置及微粒子分選系統
Branning Jr et al. Multifunction fluorescence open source in vivo/in vitro imaging system (openIVIS)
Czyżewski The Influence of a Photometric Distance on Luminance Measurements
Yemini et al. Illumination for worm tracking and behavioral imaging
CN216870943U (zh) 一种基于微透镜阵列元件的光学***
Fang et al. Application of Dimming Compensation Technology Via Liquid Crystal Lens for Non-Imaging Projection Laser Systems
Waśniowska et al. Modelling the Interaction of Illuminations with a Sensor Matrix Used in Vision Systems
Giessen et al. Microstructured optics by 3D printing
Raju et al. A commentary on the development and use of smartphone imaging devices
Le et al. Light source modeling for UltraViolet-C Light-Emitting Diodes (UV-C LEDs) with aid of fluorescent film

Legal Events

Date Code Title Description
MM4A Annulment or lapse of patent due to non-payment of fees