TWI670038B - Auxillary slicing device for slicing biological tissue, kits comprising the same and uses thereof - Google Patents
Auxillary slicing device for slicing biological tissue, kits comprising the same and uses thereof Download PDFInfo
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Abstract
本揭示內容係關於一種於活體外用以切割一生物組織的切割輔具、切割套組及其用途。所述切割輔具包含設有一進刀口之一中空套管，其中該進刀口用以使一刀片伸入，藉以切割該生物組織；一第一推桿及一第二推桿，其中該第一推桿及該第二推桿可各別地滑移入該中空套管的各別端口。所述切割套組包含該切割輔具及一刀片。本揭示內容亦包含一種用以於活體外切割一生物組織之方法。該方法包含將該生物組織置入該中空套管中，藉由在該中空套管中，滑移該第一推桿及/或該第二推桿以移動該生物組織，直到其被定位於該進刀口處下方為止，接著將該刀片一或多次伸入該進刀口，以切割該生物組織成一或多片切片，最後取出該切割後的生物組織。 The present disclosure relates to a cutting aid, a cutting set, and uses thereof for cutting a biological tissue in vitro. The cutting aid comprises a hollow sleeve provided with a cutting edge, wherein the cutting edge is used to extend a blade to cut the biological tissue; a first push rod and a second push rod, wherein the first push rod The push rod and the second push rod can be individually slid into the respective ports of the hollow sleeve. The cutting set includes the cutting aid and a blade. The present disclosure also encompasses a method for cutting a biological tissue in vitro. The method includes placing the biological tissue into the hollow cannula, by sliding the first push rod and/or the second push rod in the hollow cannula to move the biological tissue until it is positioned The cutting edge is located below, and then the blade is inserted into the cutting edge one or more times to cut the biological tissue into one or more slices, and finally the cut biological tissue is taken out.
Description
本發明係有關於一種生物組織的切割工具及切割方法，特別是有關於一種可輔助定位切割位點的生物組織的切割工具及切割方法。 The present invention relates to a cutting tool and a cutting method for a biological tissue, and more particularly to a cutting tool and a cutting method for assisting in positioning a biological tissue of a cutting site.
隨著生物技術發展與應用日新月異，對於生物組織的操作處理需求與日俱增。以切割生物體濕組織方面來說，常見的是一般外科手術中使用的手術刀，或者進一步地，例如可探入病患體內，用以切除諸如椎間盤退化或疝氣組織的經皮切割裝置(下稱疝氣切割裝置)，如美國專利公告號4,246,902、5,106,364或5,997,560所示之疝氣切割裝置等。然而，手術刀或疝氣切割裝置皆具有相同的問題，即無法依使用者需求來定位待切割組織的切割位點，以致無法獲得使用者欲求特定體積大小的組織，以利後續研發。此外，參照中華民國專利公開號200411047，其中揭示一種可用於切割細胞與組織團塊的工具，儘管該工具用以切割細胞與組織團塊的切割刀模組，可將細胞與組織團塊同時切割為至少一個(數個或數十個)以上的小團塊，然該工具仍舊面臨與上述手術刀或疝氣切割裝置相同的問題，即，無法依使用者需求來定位切割位點，以致無法獲得具有使用者欲求特定體積大小的組織，以供後續使用。 With the rapid development of biotechnology and applications, the demand for handling of biological tissues is increasing. In terms of cutting wet tissues of living organisms, it is common to use a scalpel used in general surgery, or further, for example, to penetrate into a patient to remove a percutaneous cutting device such as disc degeneration or hernia tissue (below A helium gas cutting device, such as a helium gas cutting device shown in U.S. Patent Nos. 4,246,902, 5,106,364 or 5,997,560. However, the scalpel or the hernia cutting device all have the same problem that the cutting site of the tissue to be cut cannot be positioned according to the user's needs, so that the user desires a specific volume of the tissue for subsequent development. In addition, reference is made to the Republic of China Patent Publication No. 200411047, which discloses a tool that can be used to cut cells and tissue masses, although the tool is used to cut cells and tissue blocks of the cutting knife module, and the cells can be cut simultaneously with the tissue mass. As at least one (several or tens of) small agglomerates, the tool still faces the same problem as the scalpel or hernia cutting device described above, that is, the cutting site cannot be positioned according to the user's needs, so that the tool cannot be obtained. There is a tissue that the user desires for a particular volume size for subsequent use.
目前本領域技術人員熟知可用來控制組織切割體積大小的方法係利用組織切片機來對生物組織進行切割。然而，在以組織切片機切割前，需先對生物組織進行相關的前處理，例如製備石蠟切片所必需的固定、脫水、浸潤、包埋等處理，或製備冷凍切片的低度固定及冷凍包埋等手續，此類手續會對生物組織造成不同程度的破壞，不利該生物組織的後續利用。此外，使用切片機來切割生物組織，其最大的切割厚度為100微米，並且僅能從生物組織的一端開始進行切割，而不能任意地依使用者需求於該生物組織上任一位點進行切割(例如，不能從該生物組織中間進行切割)。有鑑於此，相關領域亟需一種可輔助定位一生物組織之切割位點的切割工具，以便對生物組織進行切割。 A method well known to those skilled in the art that can be used to control the size of a tissue cutting volume utilizes a tissue microtome to cut biological tissue. However, prior to cutting with a tissue microtome, it is necessary to perform pre-treatment on the biological tissue, such as fixation, dehydration, infiltration, embedding, etc. necessary for preparing paraffin sections, or preparation of cryopreservation and cryopreservation of frozen sections. Buried and other procedures, such procedures will cause varying degrees of damage to biological tissues, which is detrimental to the subsequent use of the biological organization. In addition, a microtome is used to cut biological tissue with a maximum cut thickness of 100 microns, and can only be cut from one end of the biological tissue, and cannot be arbitrarily cut at any point on the biological tissue according to the user's needs ( For example, it is not possible to cut from the middle of the biological tissue). In view of the above, there is a need in the related art for a cutting tool that assists in locating a cutting site of a biological tissue for cutting biological tissue.
發明內容旨在提供本揭示內容的簡化摘要，以使閱讀者對本揭示內容具備基本的理解。此發明內容並非本揭示內容的完整概述，且其用意並非在指出本發明實施例的重要/關鍵元件或界定本發明的範圍。 SUMMARY OF THE INVENTION The Summary of the Disclosure is intended to provide a basic understanding of the present disclosure. This Summary is not an extensive overview of the disclosure, and is not intended to be an
本揭示內容的第一態樣在於提供一種可輔助定位於活體外(ex vivo)生物組織切割位點的切割輔具，其能依使用者需求來定位生物組織的切割位點，達到獲取使用者欲求的特定組織體積大小的效果，以利後續應用。具體而言，該切割輔具包含一中空套管、一第一推桿及一第二推桿，其中該中空套管兩端各具有開口，並設有一進刀口於其管體上，該第一推桿可滑移(slide)入該中空套管的一端口，該第二推桿可滑移入該中空套管的另一端口。 A first aspect of the present disclosure is to provide a cutting aid capable of assisting in positioning an ex vivo biological tissue cutting site, which can locate a cutting site of a biological tissue according to a user's needs, so as to obtain a user. The effect of the specific tissue size desired to facilitate subsequent application. Specifically, the cutting aid comprises a hollow sleeve, a first push rod and a second push rod, wherein the hollow sleeve has an opening at each end, and a cutting edge is provided on the tube body, the first A push rod can slide into a port of the hollow sleeve, and the second push rod can slide into the other port of the hollow sleeve.
在其他實施方式中，該中空套管更包含一設有一進刀口之蓋體。在該些實施方式中，該中空套管設有一取樣口，且該蓋體可開闔地覆蓋於該取 樣口上，以利切割後便於取出樣本(即生物組織)。依據使用需求之不同，該蓋體的面積可大於、等於或小於該取樣口。 In other embodiments, the hollow sleeve further includes a cover having a cutting edge. In some embodiments, the hollow sleeve is provided with a sampling port, and the cover body is openably covered by the take-up On the sample mouth, it is convenient to take out the sample (ie biological tissue) after cutting. The area of the cover may be greater than, equal to, or less than the sampling port, depending on the needs of use.
在特定實施方式中，為便於使生物組織置於該中空套管內時，可方便藉由肉眼確認切割位點之定位，該中空套管、該第一推桿、該第二推桿及/或該蓋體的材質為透明或半透明材質，例如玻璃或合成塑料。亦或是，該第一推桿及該第二推桿可為不透明材質，例如金屬不鏽鋼材。 In a specific embodiment, in order to facilitate the placement of the biological tissue in the hollow cannula, the positioning of the cutting site can be conveniently confirmed by the naked eye, the hollow cannula, the first push rod, the second push rod and/or Or the cover is made of a transparent or translucent material such as glass or synthetic plastic. Alternatively, the first push rod and the second push rod may be opaque materials such as metal stainless steel.
在本揭示內容一特定實施方式中，為輔助定位切割位點及調整生物組織的切割體積大小，以控制切割尺寸或提高精確度，該中空套管、該第一推桿、該第二推桿及/或該蓋體的表面設有刻度。 In a specific embodiment of the present disclosure, the hollow cannula, the first push rod, the second push rod are used to assist in positioning the cutting site and adjusting the cutting volume of the biological tissue to control the cutting size or improve the accuracy. And/or the surface of the cover is provided with a scale.
在再其他實施方式中，該切割輔具更包含一第一固定件及一第二固定件，其中該第一固定件及該第二固定件分別穿透該中空套管，藉以固定該第一推桿及該第二推桿，例如螺栓、螺釘或插銷。 In still another embodiment, the cutting aid further includes a first fixing member and a second fixing member, wherein the first fixing member and the second fixing member respectively penetrate the hollow sleeve to fix the first The push rod and the second push rod, such as bolts, screws or bolts.
非必要地，該中空套管或該蓋體設有複數個進刀口。 Optionally, the hollow sleeve or the cover is provided with a plurality of feed ports.
在本揭示內容一實施方式中，該生物組織為一豬角膜檢體。 In an embodiment of the present disclosure, the biological tissue is a porcine corneal specimen.
依據本揭示內容的一實施方式，該中空套管長度為3-20公分，較佳為5-10公分，更加為7公分。依據本揭示內容的某些實施方式，該中空套管之內管徑為0.5-5公分，較佳為1-4公分，更加為1.3公分。依據本揭示內容的其他實施方式，該進刀口寬度為0.1-2毫米，較佳為1毫米。在非必要的實施方式中，該第一推桿及/或該第二推桿的長度大於該中空套管。 According to an embodiment of the present disclosure, the hollow sleeve has a length of 3-20 cm, preferably 5-10 cm, and further 7 cm. According to some embodiments of the present disclosure, the inner diameter of the hollow sleeve is 0.5-5 cm, preferably 1-4 cm, and more preferably 1.3 cm. According to other embodiments of the present disclosure, the knife edge has a width of from 0.1 to 2 mm, preferably 1 mm. In an unnecessary embodiment, the length of the first push rod and/or the second push rod is greater than the hollow sleeve.
本揭示內容的第二態樣在於提供一種用以切割一生物組織的切割套組。依據本揭示內容的實施方式，該切割套組包含：本揭示內容的切割輔具以及一刀片，其中該刀片可伸入該進刀口，藉以切割該生物組織。 A second aspect of the present disclosure is to provide a cutting set for cutting a biological tissue. In accordance with an embodiment of the present disclosure, the cutting kit includes: a cutting aid of the present disclosure and a blade, wherein the blade can extend into the knife edge to cut the biological tissue.
本揭示內容的第三態樣在於提供一種用以切割一生物組織的方法(下稱切割方法)。依據本揭示內容的實施方式，該切割方法包含以下步驟： (1)將該生物組織置入本揭示內容的切割套組之該中空套管中；(2)藉由在該中空套管中，滑移該第一推桿及/或該第二推桿以移動該生物組織，直到其被定位於該進刀口處下方為止；以及(3)將該刀片一或多次伸入該進刀口，以切割該生物組織。 A third aspect of the present disclosure is to provide a method for cutting a biological tissue (hereinafter referred to as a cutting method). According to an embodiment of the present disclosure, the cutting method comprises the following steps: (1) placing the biological tissue into the hollow cannula of the cutting set of the present disclosure; (2) sliding the first push rod and/or the second push rod in the hollow cannula To move the biological tissue until it is positioned below the incision; and (3) projecting the blade one or more times into the incision to cut the biological tissue.
依據本揭示內容的某些實施方式，係使用包含該中空套管、該第一推桿、該第二推桿及/或該蓋體具有表面刻度的切割工具來切割該生物組織，在此情形下，該切割方法的步驟(2)更包含利用該中空套管、該第一推桿、該第二推桿及/或該蓋體的表面刻度來控制該生物組織的切割體積大小，以控制切割尺寸或提高精確度。 According to some embodiments of the present disclosure, the biological tissue is cut using a cutting tool comprising the hollow cannula, the first push rod, the second push rod, and/or the cover having a surface scale, in which case The step (2) of the cutting method further comprises controlling the cutting volume of the biological tissue by using the hollow sleeve, the first push rod, the second push rod and/or the surface scale of the cover body to control Cut size or increase accuracy.
本揭示內容一或多個實施方式的詳細內容及說明闡述如下。在參閱以下的詳細說明及申請專利範圍後，本揭示內容的其餘特徵及優點將顯而易見。 The details and description of one or more embodiments of the present disclosure are set forth below. The remaining features and advantages of the present disclosure will be apparent from the description and appended claims.
100、200、300、400、500、600‧‧‧切割輔具 100, 200, 300, 400, 500, 600‧‧‧ cutting aids
110、210、310、410、510、610‧‧‧中空套管 110, 210, 310, 410, 510, 610‧‧‧ hollow casing
112、212、312、412、512、612‧‧‧進刀口 112, 212, 312, 412, 512, 612‧‧ ‧ inlet
120、220、320、420、520、620‧‧‧第一推桿 120, 220, 320, 420, 520, 620‧‧‧ first putter
130、230、330、430、530、630‧‧‧第二推桿 130, 230, 330, 430, 530, 630‧‧‧ second putter
140‧‧‧刀片 140‧‧‧blade
414、514‧‧‧蓋體 414, 514‧‧ ‧ cover
616‧‧‧第一固定件 616‧‧‧First fixture
618‧‧‧第二固定件 618‧‧‧Second fixture
T‧‧‧生物組織 T‧‧‧ Biological organization
P‧‧‧穿孔 P‧‧‧Perforation
在參閱以下的詳細說明、申請專利範圍及附隨圖式後，本揭示內容及其他特徵、態樣及優點將更明顯易懂，其中：第1圖為本揭示內容之切割輔具的一實施例之示意圖；第2A圖為本揭示內容之切割套組的透視圖；第2B圖為本揭示內容之切割套組的剖面圖；第3圖為本揭示內容之切割輔具的另一實施例之示意圖；第4圖為本揭示內容之切割輔具的另一實施例之示意圖；第5圖為本揭示內容之切割輔具的另一實施例之示意圖；第6A圖為第5圖之背視透視圖； 第6B圖為第5圖之背視結構分解圖；第7圖為本揭示內容之切割輔具的另一實施例之示意圖；以及第8圖為本揭示內容之切割輔具的另一實施例之示意圖。 The disclosure and other features, aspects, and advantages will be more apparent from the following detailed description, appended claims. 2A is a perspective view of a cutting kit of the present disclosure; FIG. 2B is a cross-sectional view of the cutting kit of the present disclosure; FIG. 3 is another embodiment of the cutting aid of the present disclosure 4 is a schematic view of another embodiment of the cutting aid of the present disclosure; FIG. 5 is a schematic view of another embodiment of the cutting aid of the disclosure; FIG. 6A is the back of FIG. Perspective view 6B is an exploded view of the rear view of FIG. 5; FIG. 7 is a schematic view of another embodiment of the cutting aid of the present disclosure; and FIG. 8 is another embodiment of the cutting aid of the present disclosure. Schematic diagram.
根據慣常的作業方式，圖中各種特徵與元件並未依比例繪製，其繪製方式是為了以最佳的方式呈現與本發明相關的具體特徵與元件。此外，在不同圖式間，以相同或相似的元件符號來指稱相似的元件/部件。 The various features and elements in the figures are not drawn to scale, and are in the In addition, similar elements/components are referred to by the same or similar element symbols throughout the different drawings.
為了使本揭示內容的敘述更加詳盡與完備，下文針對了本發明的實施態樣與具體實施例提出了說明性的描述；但這並非實施或運用本發明具體實施例的唯一形式。實施方式中涵蓋了多個具體實施例的特徵以及用以建構與操作這些具體實施例的方法步驟與其順序。然而，亦可利用其他具體實施例來達成相同或均等的功能與步驟順序。 The description of the embodiments of the present invention is intended to be illustrative and not restrictive. The features of various specific embodiments, as well as the method steps and sequences thereof, are constructed and manipulated in the embodiments. However, other specific embodiments may be utilized to achieve the same or equivalent function and sequence of steps.
除非本說明書另有定義，此處所用的科學與技術詞彙之含義與本發明所屬技術領域中具有通常知識者所理解與慣用的意義相同。此外，在不和上下文衝突的情形下，本說明書所用的單數名詞涵蓋該名詞的複數型；而所用的複數名詞時亦涵蓋該名詞的單數型。 The scientific and technical terms used herein have the same meaning as commonly understood by those of ordinary skill in the art to which the invention pertains, unless otherwise defined herein. In addition, the singular noun used in this specification covers the plural of the noun in the case of no conflict with the context; the plural noun of the noun is also included in the plural noun used.
雖然用以界定本發明較廣範圍的數值範圍與參數皆是約略的數值，此處已儘可能精確地呈現具體實施例中的相關數值。然而，任何數值本質上不可避免地含有因個別測試方法所致的標準偏差。在此處，「約」通常係指實際數值在一特定數值或範圍的正負10%、5%、1%或0.5%之內。或者是，「約」一詞代表實際數值落在平均值的可接受標準誤差之內，視本發明所屬技術領域 中具有通常知識者的考量而定。除了實驗例之外，或除非另有明確的說明，當可理解此處所用的所有範圍、數量、數值與百分比(例如用以描述材料用量、時間長短、溫度、操作條件、數量比例及其他相似者)均經過「約」的修飾。因此，除非另有相反的說明，本說明書與附隨申請專利範圍所揭示的數值參數皆為約略的數值，且可視需求而更動。至少應將這些數值參數理解為所指出的有效位數與套用一般進位法所得到的數值。 Although numerical ranges and parameters are used to define a broad range of values for the present invention, the relevant values in the specific embodiments have been presented as precisely as possible. However, any numerical value inherently inevitably contains standard deviations due to individual test methods. As used herein, "about" generally means that the actual value is within plus or minus 10%, 5%, 1%, or 0.5% of a particular value or range. Or, the word "about" means that the actual value falls within the acceptable standard error of the average value, depending on the technical field to which the present invention pertains. It depends on the consideration of the usual knowledge. Except for the experimental examples, or unless otherwise explicitly stated, all ranges, quantities, values, and percentages used herein are understood (eg, to describe the amount of material used, the length of time, the temperature, the operating conditions, the quantity ratio, and the like. Are all modified by "about". Therefore, unless otherwise indicated to the contrary, the numerical parameters disclosed in the specification and the appended claims are intended to be At a minimum, these numerical parameters should be understood as the number of significant digits indicated and the values obtained by applying the general carry method.
「個體」(subject或individual)一詞係指一種可利用本揭示內容切割輔具、切割套組及切割方法來切割的生物組織之來源對象。在某些實施方式中，該來源對象係指哺乳動物。除非有具體指出其中一種性別，「個體」一詞意指男性及女性二者。例示性之「個體」包括，但不限於，人、大鼠、小鼠、豚鼠、猴子、豬、山羊、牛、馬、狗、貓、鳥及雞。在一具體實施方式中，該個體為豬。 The term "subject" or "individual" refers to a source object of biological tissue that can be cut using the cutting aids, cutting sets, and cutting methods of the present disclosure. In certain embodiments, the source object refers to a mammal. Unless specifically stated as one of the genders, the term "individual" means both male and female. Exemplary "individuals" include, but are not limited to, humans, rats, mice, guinea pigs, monkeys, pigs, goats, cows, horses, dogs, cats, birds, and chickens. In a specific embodiment, the individual is a pig.
「生物組織」(biological tissue)包括來自個體的組成部分(如器官)的組織，包括，但不限於，外皮組織(例如皮膚的部分)、口腔組織(例如口、舌、顎、牙齦)、呼吸組織(例如咽、喉、氣管、支氣管、肺、橫膈膜)、胃腸組織(例如食道、胃、肝臟、膽囊、胰腺、腸、結腸、直腸和肛門)、心血管組織(例如心臟、血管)、內分泌組織(例如下丘腦、腦垂體、松果體或松果腺、甲狀腺、甲狀旁腺、腎上腺)和泌尿生殖組織(例如腎臟、輸尿管、膀胱、尿道、卵巢、輸卵管、子宮、***、乳腺、睾丸、輸精管、精囊、***、陰莖)、肌肉組織、神經組織(例如腦、脊髓、神經)、軟骨組織(例如軟骨、韌帶、肌腱)及眼。生物樣品可以是任何類型的生物體組織，包括健康組織和病變組織(例如，癌症、惡性、壞死等)二者。在一具體實施方式中，該生物組織為眼角膜。 ""biological tissue" includes tissue from a component (such as an organ) of an individual, including, but not limited to, a dermal tissue (such as a portion of the skin), an oral tissue (such as the mouth, tongue, palate, gums), and breathing. Tissue (eg, pharynx, larynx, trachea, bronchi, lung, diaphragm), gastrointestinal tissue (eg, esophagus, stomach, liver, gallbladder, pancreas, intestine, colon, rectum, and anus), cardiovascular tissue (eg, heart, blood vessels) Endocrine tissue (eg hypothalamus, pituitary gland, pineal or pineal gland, thyroid, parathyroid gland, adrenal gland) and genitourinary tissue (eg kidney, ureter, bladder, urethra, ovary, fallopian tube, uterus, vagina, Breast, testis, vas deferens, seminal vesicles, prostate, penis), muscle tissue, nerve tissue (such as brain, spinal cord, nerves), cartilage tissue (such as cartilage, ligaments, tendons) and eyes. The biological sample can be any type of biological tissue, including both healthy tissue and diseased tissue (eg, cancer, malignancy, necrosis, etc.). In a specific embodiment, the biological tissue is the cornea of the eye.
如上所述，本領域技術人員所熟知用以切割生物組織的器械，不外乎手術刀、疝氣切割裝置或組織切片機等習知的切割工具，然而該些切割工具皆無法讓使用者可依自身需求而任意定位所欲切割的位點，以致無法獲得欲求體積大小的切割組織。因此，本發明目的之一在於提供一種可用以輔助使用者定位生物組織之切割位點的切割輔具，以及包含該切割輔具之切割套組。該切割輔具及切割套組皆可讓使用者依需求將生物組織切割成欲求的體積大小，以方便後續利用。為說明本發明切割輔具及切割套組的使用方式，本發明亦提供利用該切割套組來切割生物組織的方法，以利使用者使用該切割輔具及切割套組來獲得欲求的切割後的生物組織。本發明切割輔具及切割套組實為一種新穎、成本低廉且操作容易之切割工具，易於大量生產，適合大力推廣應用。 As described above, the instruments for cutting biological tissues are well known to those skilled in the art, and are not only conventional cutting tools such as scalpels, hernia cutting devices or tissue microtome, but these cutting tools are not available to the user. The site to be cut is arbitrarily positioned according to its own needs, so that the cut tissue of the desired volume size cannot be obtained. Accordingly, it is an object of the present invention to provide a cutting aid that can be used to assist a user in locating a cutting site of a biological tissue, and a cutting set comprising the cutting aid. The cutting aid and the cutting set can allow the user to cut the biological tissue into a desired volume according to requirements, so as to facilitate subsequent use. In order to illustrate the use of the cutting aid and the cutting set of the present invention, the present invention also provides a method for cutting biological tissue by using the cutting set, so that the user can use the cutting aid and the cutting set to obtain the desired cutting. Biological organization. The cutting aid and the cutting set of the invention are a novel, low-cost and easy-to-operate cutting tool, which is easy to mass-produce and is suitable for popularization and application.
第1圖為本揭示內容之切割輔具的一實施例(即切割輔具100)之示意圖。本揭示內容之輔助切割生物組織用的切割輔具100包含一中空套管110、一第一推桿120及一第二推桿130，其中中空套管110兩端各具有開口並且一側管壁上還設有一進刀口112。在結構上，第一推桿120可滑動地伸入中空套管110的一端口，且第二推桿130可滑動地伸入該中空套管110的另一端口。 1 is a schematic view of an embodiment of a cutting aid of the present disclosure (ie, cutting aid 100). The cutting aid 100 for assisting cutting biological tissue of the present disclosure comprises a hollow sleeve 110, a first push rod 120 and a second push rod 130, wherein the hollow sleeve 110 has an opening at each end and a side wall There is also a feed edge 112. Structurally, the first push rod 120 slidably extends into one port of the hollow sleeve 110, and the second push rod 130 slidably extends into the other port of the hollow sleeve 110.
第2A圖及第2B圖分別為本揭示內容之切割套組的透視圖及剖面圖，其包含本揭示內容之切割輔具100以及一刀片140。如圖所示，在非限制性的實施方式中，當使用本揭示內容切割輔具100來切割源自於一個體之生物組織T(例如，豬角膜檢體)時，首先將生物組織T置入該中空套管110內。接著，透過在中空套管110內滑移第一推桿120及第二推桿130，而將生物組織T推移至進刀口112下方處，並分別利用第一推桿120與第二推桿130來將生物組織T夾持並固定於一特定位置(第2B圖)。之後，將刀片140伸入進刀口112內切割生物組 織T；接著，再將切下後的生物組織移出。在其他實施方式中，亦可依使用者的實際需要，重複前述步驟，即，於每次切割後，調整生物組織T的位置使位於進刀口下方，再次利用刀片140切割，直到獲得欲求數量的生物組織T的切片為止。 2A and 2B are perspective and cross-sectional views, respectively, of the cutting kit of the present disclosure, including the cutting aid 100 and a blade 140 of the present disclosure. As shown, in a non-limiting embodiment, when the cutting aid 100 of the present disclosure is used to cut a biological tissue T derived from a body (eg, a porcine corneal specimen), the biological tissue T is first placed. Into the hollow sleeve 110. Then, by sliding the first push rod 120 and the second push rod 130 in the hollow sleeve 110, the biological tissue T is pushed to the lower side of the infeed port 112, and the first push rod 120 and the second push rod 130 are respectively used. The biological tissue T is clamped and fixed at a specific position (Fig. 2B). Thereafter, the blade 140 is extended into the cutting edge 112 to cut the biological group. Weave T; then, remove the cut tissue. In other embodiments, the foregoing steps may be repeated according to the actual needs of the user, that is, after each cutting, the position of the biological tissue T is adjusted so as to be located below the incision port, and again cut by the blade 140 until the desired quantity is obtained. The section of the biological tissue T is up.
第3圖為本揭示內容之切割輔具的另一實施例(即切割輔具200)之示意圖。切割輔具200於結構上與第1圖之切割輔具100相似，同樣包含一中空套管210，其上設有一進刀口212；一第一推桿220及一第二推桿230，配置方式與第1圖之切割輔具100相似，在此不另贅述。與第1圖切割輔具100不同之處在於，切割輔具200之中空套管210的管壁表面設有刻度，以利使用者更精確地調整生物組織之固定位置及切割厚度，藉以控制切割尺寸或提高切割的精確度。 Figure 3 is a schematic view of another embodiment of the cutting aid of the present disclosure (i.e., cutting aid 200). The cutting aid 200 is similar in structure to the cutting aid 100 of FIG. 1 and also includes a hollow sleeve 210 having a cutting edge 212; a first push rod 220 and a second push rod 230. Similar to the cutting aid 100 of FIG. 1 , it will not be further described herein. The difference from the cutting aid 100 of FIG. 1 is that the surface of the wall of the hollow sleeve 210 of the cutting aid 200 is provided with a scale for the user to more precisely adjust the fixed position and the cutting thickness of the biological tissue, thereby controlling the cutting. Size or improve the accuracy of the cut.
需注意的是，中空套管210表面刻度設置在進刀口212兩側，係以中空套管210的任一端為原點，向另一端連續性地設置，並涵蓋進刀口212所在位置，或以進刀口212之一側為原點，向進刀口212之另一側連續性地設置，並涵蓋進刀口212所在位置，以利使用者用來輔助定位切割位點及調整生物組織T的切割體積大小。 It should be noted that the surface of the hollow sleeve 210 is disposed on both sides of the infeed port 212, and the end of the hollow sleeve 210 is taken as the origin, and is continuously disposed to the other end, and covers the position of the incision 212, or One side of the incision port 212 is the origin, and is disposed continuously to the other side of the incision port 212, and covers the position of the incision port 212 for the user to assist in positioning the cutting site and adjusting the cutting volume of the biological tissue T. size.
第4圖為本揭示內容之切割輔具的另一實施例(即切割輔具300)之示意圖。切割輔具300與切割輔具100具有相似之結構及配置，不同之處在於切割輔具300之中空套管310包含複數個進刀口312，以便於擬對待切割的生物組織T進行多定點之複數次切割時，可直接進行複數次切割，而省略多次對該生物組織T的重新定位，達到節省時間的功效。在某些實施方式中，相鄰二個進刀口之間的間隙約為1-10毫米，例如，約1、1.5、2、2.5、3、3.5、4、4.5、5、5.5、6、6.5、7、7.5、8、8.5、9、9.5或10毫米。較佳地，該間隙約為2-5毫米，例如約2、2.5、3、3.5、4、4.5、5毫米。更佳地，該間隙約為2毫米。 Figure 4 is a schematic view of another embodiment of the cutting aid of the present disclosure (i.e., cutting aid 300). The cutting aid 300 has a similar structure and configuration to the cutting aid 100, except that the hollow sleeve 310 of the cutting aid 300 includes a plurality of cutting edges 312 for multi-pointing of the biological tissue T to be cut. In the case of secondary cutting, multiple cuttings can be directly performed, and the repositioning of the biological tissue T is omitted a plurality of times, thereby achieving a time saving effect. In some embodiments, the gap between adjacent two infeeds is about 1-10 mm, for example, about 1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 6.5. 7, 7, 7.5, 8, 8.5, 9, 9.5 or 10 mm. Preferably, the gap is about 2-5 mm, such as about 2, 2.5, 3, 3.5, 4, 4.5, 5 mm. More preferably, the gap is about 2 mm.
第5圖、第6A圖及第6B圖繪示本揭示內容另一態樣之切割輔具，其中第5圖為切割輔具400之外觀圖，第6A圖及6B圖則分別為其背視透視圖及背視結構分解圖。如圖所示，切割輔具400與切割輔具100具有相似之結構及配置，不同之處在於切割輔具400之中空套管410管壁之一側上挖設一取樣口，並具有一可開闔的蓋體414覆蓋於其上。蓋體414一端利用耦接方式與中空套管410連接，並可旋轉地掀開蓋體414(第6A圖及第6B圖)。亦或是，本領域技術人員可利用卡合方式或依據實際使用狀況和通常經驗來調整或變化蓋體414與中空套管410的連接方式。在一實施方式中，蓋體414上設置進刀口412，以便於切割完生物組織T後，往上掀開蓋體414，即可方便取出切割後的生物組織T。 5, 6A, and 6B illustrate another embodiment of the cutting aid of the present disclosure, wherein FIG. 5 is an external view of the cutting aid 400, and FIGS. 6A and 6B are respectively viewed from the back. Perspective view and back view structure exploded view. As shown in the figure, the cutting aid 400 has a similar structure and configuration as the cutting aid 100, except that a sampling port is dug on one side of the wall of the hollow sleeve 410 of the cutting aid 400, and has a An open cover 414 is overlaid thereon. One end of the cover body 414 is coupled to the hollow sleeve 410 by a coupling method, and the cover body 414 is rotatably opened (Fig. 6A and Fig. 6B). Alternatively, those skilled in the art can adjust or change the manner in which the cover 414 is connected to the hollow sleeve 410 by means of a snap fit or according to actual use conditions and usual experience. In one embodiment, the cover body 414 is provided with a cutting edge 412, so that after the biological tissue T is cut, the cover body 414 is opened upward, and the cut biological tissue T can be conveniently taken out.
第7圖為本揭示內容之切割輔具的另一實施例(即切割輔具500)之示意圖。切割輔具500與切割輔具400具有相似之結構，二者不同之處在於相較於切割輔具400之蓋體414上僅設置一進刀口412，而切割輔具500之蓋體514上設置複數個進刀口512。 Figure 7 is a schematic view of another embodiment of the cutting aid of the present disclosure (i.e., cutting aid 500). The cutting aid 500 has a similar structure to the cutting aid 400. The difference is that only one cutting edge 412 is provided on the cover 414 of the cutting aid 400, and the cover 514 of the cutting aid 500 is disposed. A plurality of inlets 512.
第8圖為本揭示內容之切割輔具的另一實施例(即切割輔具600)之示意圖。切割輔具600與切割輔具100具有相似之結構，不同之處在於切割輔具600之更包含一第一固定件616及一第二固定件618，其中第一固定件616及第二固定件618分別藉由穿孔P穿透中空套管610(如箭頭所示)，藉以固定第一推桿620及第二推桿630，以避免在進行切割時，第一推桿620及/或第二推桿630與中空套管610之間產生相對位移，以致無法在該生物組織T上定位，或是無法在欲求的切割位點進行切割。可利用諸如鎖附或插合(例如螺栓、螺釘或插銷)等方式來連結第一固定件616及第二固定件618與中空套管610。亦或是，本領域技術人員可依據實際使用狀況和通常經驗來調整或變化。非必要地，第一推桿 620及/或第二推桿630於其表面更設有刻度。該刻度係以第一推桿620及/或第二推桿630的任一端為原點，向另一端連續性地設置。亦或是，將該刻度設置在第一推桿620及/或第二推桿630屬於滑移入中空套管610之一端或非屬於滑移入中空套管610之一端，以輔助使用者定位切割位點及調整所欲切割之生物組織T的體積大小，據以控制切割尺寸或提高切割精確度。 Figure 8 is a schematic view of another embodiment of the cutting aid of the present disclosure (i.e., cutting aid 600). The cutting aid 600 has a similar structure to the cutting aid 100, except that the cutting aid 600 further includes a first fixing member 616 and a second fixing member 618, wherein the first fixing member 616 and the second fixing member 618 respectively penetrates the hollow sleeve 610 (shown by the arrow) through the through hole P, thereby fixing the first push rod 620 and the second push rod 630 to avoid the first push rod 620 and/or the second when cutting is performed. The relative displacement between the push rod 630 and the hollow sleeve 610 is such that it cannot be positioned on the biological tissue T or can not be cut at the desired cutting site. The first fixing member 616 and the second fixing member 618 and the hollow sleeve 610 may be coupled by means such as a locking or a plug (for example, a bolt, a screw, or a bolt). Or, those skilled in the art can adjust or change according to actual use conditions and usual experience. Non-essentially, the first putter The 620 and/or the second push rod 630 is further provided with a scale on its surface. The scale is set to the origin of the first push rod 620 and/or the second push rod 630, and is continuously provided to the other end. Alternatively, the scale is disposed on the first push rod 620 and/or the second push rod 630 belongs to one end of the sliding hollow sleeve 610 or does not belong to one end of the sliding hollow sleeve 610 to assist the user in positioning. Cutting the site and adjusting the volume of the biological tissue T to be cut, thereby controlling the cutting size or improving the cutting accuracy.
在某些實施方式中，第3圖之中空套管210、第8圖之第一推桿620及第二推桿630可與本揭示內容之其他中空套管、第一推桿及第二推桿交替互換或合併使用，以利使用者依其需求藉由刻度來輔助定位切割位點及調整生物組織T的切割體積大小，以控制切割尺寸或提高切割精確度。因此，使用本揭示內容之切割輔具來輔助切割或使用本揭示內容之切割套組來切割一生物組織T之方法，更包含利用中空套管210、第一推桿620及/或第二推桿630的表面刻度來控制生物組織T的切割厚度。在特定實施方式中，中空套管具有蓋體，該蓋體表面可設置刻度。 In some embodiments, the hollow sleeve 210 of FIG. 3, the first push rod 620 and the second push rod 630 of FIG. 8 can be combined with other hollow sleeves, first push rods and second pushes of the present disclosure. The rods are alternately interchanged or combined to facilitate the user to assist in locating the cutting site and adjusting the cutting volume of the biological tissue T by means of the scale to control the cutting size or to improve the cutting precision. Thus, the use of the cutting aid of the present disclosure to assist in cutting or using the cutting set of the present disclosure to cut a biological tissue T further includes utilizing the hollow cannula 210, the first pusher 620, and/or the second push The surface of the rod 630 is scaled to control the cutting thickness of the biological tissue T. In a particular embodiment, the hollow cannula has a cover that can be dimensioned.
在某些實施方式中，該中空套管長度約為3-20公分，例如，約3、3.5、4、4.5、5、5.5、6、6.5、7、7.5、8、8.5、9、9.5、10、10.5、11、11.5、12、12.5、13、13.5、14、14.5、15、15.5、16、16.5、17、17.5、18、18.5、19、19.5或20公分。較佳地，該中空套管長度約為5-10公分，例如，約5、5.5、6、6.5、7、7.5、8、8.5、9、9.5、10公分。更佳地，該中空套管長度約為7公分。 In certain embodiments, the hollow sleeve is about 3-20 cm in length, for example, about 3, 3.5, 4, 4.5, 5, 5.5, 6, 6.5, 7, 7.5, 8, 8.5, 9, 9.5, 10, 10.5, 11, 11.5, 12, 12.5, 13, 13.5, 14, 14.5, 15, 15.5, 16, 16.5, 17, 17.5, 18, 18.5, 19, 19.5 or 20 cm. Preferably, the hollow sleeve is about 5-10 cm in length, for example, about 5, 5.5, 6, 6.5, 7, 7.5, 8, 8.5, 9, 9.5, 10 cm. More preferably, the hollow sleeve is about 7 cm in length.
在某些實施方式中，該中空套管內管徑約為0.5-5公分，例如，約0.5、0.6、0.7、0.8、0.9、1.0、1.1、1.2、1.3、1.4、1.5、1.6、1.7、1.8、1.9、2.0、2.1、2.2、2.3、2.4、2.5、2.6、2.7、2.8、2.9、3.0、3.1、3.2、3.3、3.4、3.5、3.6、3.7、3.8、3.9、4.0、4.1、4.2、4.3、4.4、4.5、4.6、4.7、4.8、4.9或5.0公分。較 佳地，該中空套管內管徑約為1-4公分，例如，約1.0、1.1、1.2、1.3、1.4、1.5、1.6、1.7、1.8、1.9、2.0、2.1、2.2、2.3、2.4、2.5、2.6、2.7、2.8、2.9、3.0、3.1、3.2、3.3、3.4、3.5、3.6、3.7、3.8、3.9、4.0公分。更佳地，該中空套管內管徑約為1.3公分。 In some embodiments, the inner diameter of the hollow sleeve is about 0.5-5 cm, for example, about 0.5, 0.6, 0.7, 0.8, 0.9, 1.0, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 2.0, 2.1, 2.2, 2.3, 2.4, 2.5, 2.6, 2.7, 2.8, 2.9, 3.0, 3.1, 3.2, 3.3, 3.4, 3.5, 3.6, 3.7, 3.8, 3.9, 4.0, 4.1, 4.2, 4.3, 4.4, 4.5, 4.6, 4.7, 4.8, 4.9 or 5.0 cm. More Preferably, the inner diameter of the hollow sleeve is about 1-4 cm, for example, about 1.0, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 2.0, 2.1, 2.2, 2.3, 2.4, 2.5, 2.6, 2.7, 2.8, 2.9, 3.0, 3.1, 3.2, 3.3, 3.4, 3.5, 3.6, 3.7, 3.8, 3.9, 4.0 cm. More preferably, the inner diameter of the hollow sleeve is about 1.3 cm.
在某些實施方式中，該進刀口寬度約為0.1-2毫米，例如，約0.1、0.2、0.3、0.4、0.5、0.6、0.7、0.8、0.9、1.0、1.1、1.2、1.3、1.4、1.5、1.6、1.7、1.8、1.9或2.0毫米。較佳地，該進刀口寬度約為1毫米。 In certain embodiments, the knife edge has a width of about 0.1 to 2 mm, for example, about 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1.0, 1.1, 1.2, 1.3, 1.4, 1.5. , 1.6, 1.7, 1.8, 1.9 or 2.0 mm. Preferably, the knife edge has a width of about 1 mm.
在某些實施方式中，該刀片於該進刀口的切割面積約為該中空套管內管截面積的5%-99%，例如，約5%、10%、15%、20%、25%、30%、35%、40%、45%、50%、55%、60%、65%、70%、75%、80%、81%、82%、83%、84%、85%、86%、87%、88%、89%、90%、91%、92%、93%、94%、95%、96%、97%、98%或99%。較佳地，切割面積約為該中空套管內管截面積的50%-95%，例如，約50%、55%、60%、65%、70%、75%、80%、81%、82%、83%、84%、85%、86%、87%、88%、89%、90%、91%、92%、93%、94%或95%。更佳地，切割面積約為該中空套管內管截面積的70%-90%，例如，約70%、75%、80%、81%、82%、83%、84%、85%、86%、87%、88%、89%或90%。在一實施例中，切割面積約為該中空套管內管截面積的50%。在其他實施例中，切割面積約為該中空套管內管截面積的75%。在一特定實施例中，切割面積約為該中空套管內管截面積的99%。 In some embodiments, the cutting area of the blade at the knife edge is about 5% to 99% of the cross-sectional area of the inner tube of the hollow sleeve, for example, about 5%, 10%, 15%, 20%, 25%. 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 81%, 82%, 83%, 84%, 85%, 86 %, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98% or 99%. Preferably, the cutting area is about 50%-95% of the cross-sectional area of the inner tube of the hollow sleeve, for example, about 50%, 55%, 60%, 65%, 70%, 75%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94% or 95%. More preferably, the cutting area is about 70%-90% of the cross-sectional area of the inner tube of the hollow sleeve, for example, about 70%, 75%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89% or 90%. In one embodiment, the cut area is about 50% of the cross-sectional area of the inner tube of the hollow sleeve. In other embodiments, the cut area is about 75% of the cross-sectional area of the inner tube of the hollow sleeve. In a particular embodiment, the cut area is about 99% of the cross-sectional area of the inner tube of the hollow sleeve.
此外，可在不影響刀片伸入進刀口的情形下，以一補強材料補強進刀口附近之外管壁的結構，例示性之補強材料包含，但不限於，支撐片、黏 土、樹脂、合成塑料及其組合。舉例來說，可於進刀口附近之外管壁的側面塗佈一層補強材料，據以穩固中空套管的結構。 In addition, the structure of the pipe wall outside the vicinity of the cutting edge can be reinforced by a reinforcing material without affecting the penetration of the blade into the cutting edge. The exemplary reinforcing material includes, but is not limited to, a supporting piece and a viscous material. Earth, resin, synthetic plastics and combinations thereof. For example, a layer of reinforcing material may be applied to the side of the pipe wall outside the vicinity of the infeed, thereby stabilizing the structure of the hollow casing.
在非限制性的實施方式中，該第一推桿及/或該第二推桿的長度大於該中空套管，藉以使該第一推桿及/或該第二推桿可相對於該中空套管之移動，利於取出切割後之生物組織。此外或亦或是，可依待切割之生物組織T的原曲率來調整該第一推桿及/或該第二推桿與生物組織接觸之一端的形狀(例如，可為平面或是圓弧內凹面)，以確保操作時生物組織T不會偏向管壁任一側。 In a non-limiting embodiment, the length of the first push rod and/or the second push rod is greater than the hollow sleeve, so that the first push rod and/or the second push rod can be opposite to the hollow The movement of the cannula facilitates the removal of the biological tissue after cutting. In addition or in addition, the shape of one end of the contact between the first push rod and/or the second push rod and the biological tissue can be adjusted according to the original curvature of the biological tissue T to be cut (for example, it can be a plane or an arc The inner surface is concave to ensure that the biological tissue T does not deflect toward either side of the tube wall during operation.
在可任選的實施方式中，為便於使生物組織T置於該中空套管內時，可方便地藉由肉眼確認該生物組織T切割位點之定位，該中空套管、該第一推桿、該第二推桿及/或該蓋體的材質為一透明或半透明材質。舉例來說，該透明或半透明材質為玻璃或合成塑料包括，但不限於，聚乙烯對苯二甲酸酯(Polyethylene Terephthalate，PET)、高密度聚乙烯(High Density Polyethylene，HDPE)、聚氯乙烯(Polyvinylchloride，PVC)、低密度聚乙烯(Low Density Polyethylene，LDPE)、聚丙烯(Polypropylene，PP)、聚苯乙烯(Polystyrene，PS)、聚碳酸脂(Polycarbonate，PC)、聚乳酸(Poly Lactic Acid，PLA)、丙烯腈-丁二烯-苯乙烯樹脂(Acrylonitrile butadiene styrene，ABS)、聚甲基丙烯酸甲酯(poly(methyl methacrylate)，PMMA)或其組合。亦或是，該第一推桿及該第二推桿可為不透明材質，例如，木材、竹材、不透明硬質塑料、橡膠、硬矽膠、複合材料或鋼材。在某些實施方式中，為便於切割操作並辨識位置提高精準度，該中空套管、該第一推桿及/或該第二推桿與該生物組織之間，可具有明顯色差對比，即該中空套管、該第一推桿及/或該第二推桿使用明顯具有對比之二種以上的顏色，以利肉眼可清楚辨識。 In an optional embodiment, in order to facilitate the placement of the biological tissue T in the hollow cannula, the positioning of the T-cut site of the biological tissue can be conveniently confirmed by the naked eye, the hollow cannula, the first push The rod, the second push rod and/or the cover are made of a transparent or translucent material. For example, the transparent or translucent material is glass or synthetic plastic including, but not limited to, Polyethylene Terephthalate (PET), High Density Polyethylene (HDPE), and polychlorinated polyethylene. Polyvinylchloride (PVC), Low Density Polyethylene (LDPE), Polypropylene (PP), Polystyrene (PS), Polycarbonate (PC), Poly Lactic (Poly Lactic) Acid, PLA), Acrylonitrile butadiene styrene (ABS), poly(methyl methacrylate), PMMA, or a combination thereof. Alternatively, the first pusher and the second pusher may be opaque materials such as wood, bamboo, opaque hard plastic, rubber, hard silicone, composite or steel. In some embodiments, in order to facilitate the cutting operation and identify the position improving accuracy, the hollow sleeve, the first push rod and/or the second push rod and the biological tissue may have a significant color difference contrast, ie The hollow sleeve, the first push rod and/or the second push rod use two or more colors which are obviously contrasted, so that the naked eye can be clearly recognized.
雖然上文實施方式中揭露本揭示內容的具體實施例，本發明所屬技術領域中具有通常知識者當可對其進行各種更動與修飾。上文的說明書、實施例及實驗數據對本揭示內容作為例示性實施方式中的結構及使用方式做出完整的描述。儘管上文已描述本揭示內容中各種實施方式有一定程度的特性，或參照一或多個各別實施方式，本發明所屬領域技術具有通常知識者仍能在不悖離本揭示內容精神及範圍情形下，對已揭示的實施方式進行眾多修改。 While the embodiments of the present disclosure are disclosed in the foregoing embodiments, those of ordinary skill in the art are capable of various changes and modifications. The above description, examples, and experimental data are a complete description of the structure and manner of use of the present disclosure as exemplary embodiments. Although the various embodiments of the present disclosure have been described above with a certain degree of characteristics, or with reference to one or more specific embodiments, those of ordinary skill in the art to which the present invention pertains can still deviate from the spirit and scope of the present disclosure. In the circumstances, numerous modifications have been made to the disclosed embodiments.
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| CN104093370A (en) * | 2011-11-23 | 2014-10-08 | 利思梅德株式会社 | Surgical instrument |
| CN204585329U (en) * | 2015-04-30 | 2015-08-26 | 天津蒙特立医疗科技有限责任公司 | A kind of Multifunction biological medicine research experiment automatic clinical microtome |
| CN206365929U (en) * | 2016-08-01 | 2017-08-01 | 北京大学第一医院 | Measurement apparatus for Minimally Invasive Surgery |
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| CN104093370A (en) * | 2011-11-23 | 2014-10-08 | 利思梅德株式会社 | Surgical instrument |
| CN204585329U (en) * | 2015-04-30 | 2015-08-26 | 天津蒙特立医疗科技有限责任公司 | A kind of Multifunction biological medicine research experiment automatic clinical microtome |
| CN206365929U (en) * | 2016-08-01 | 2017-08-01 | 北京大学第一医院 | Measurement apparatus for Minimally Invasive Surgery |
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