TWI634905B - An oxygen supply material having skin whitening function - Google Patents
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Abstract
本發明提供具有皮膚美白功能的供氧材料，所述具有皮膚美白功能的供氧材料包括固體氧源、活化劑、催化劑；所述固體氧源係選自於由過氧化物和過碳酸物所組成的群組；所述具有皮膚美白功能的供氧材料可以置於生活用品中，所述生活用品包含口罩、面罩、面膜、胸罩、胸貼、溢乳貼、衛生棉、紙尿褲、衛生護墊、一次性衛生用品、創可貼、包紮紗布、盒型容器。 The present invention provides an oxygen supply material having a skin whitening function, the oxygen supply material having a skin whitening function comprising a solid oxygen source, an activator, and a catalyst; the solid oxygen source is selected from the group consisting of a peroxide and a percarbonate. The group of the oxygen supply materials having the skin whitening function can be placed in the daily necessities, and the daily necessities include a mask, a mask, a mask, a bra, a chest patch, a breast patch, a sanitary napkin, a diaper, a sanitary pad, Disposable hygiene products, band-aids, bandage gauze, box-type containers.
Description
本發明係關於一種氣態皮膚供氧美白產品及其應用，屬於醫學美容技術領域。 The invention relates to a gaseous skin oxygen supply whitening product and an application thereof, and belongs to the technical field of medical beauty.
人體皮膚黑色素的存在主要是對抗紫外線對皮膚的傷害，但以現代人的審美觀而言，黑色素也對許多人造成莫大的困擾。例如：雀斑，老人斑，黃褐斑，汗斑，乳暈色素沉澱發黑，私密處黑色素沉澱。 The presence of melanin in human skin is mainly to protect against skin damage caused by ultraviolet rays. However, in terms of modern aesthetics, melanin also causes great trouble to many people. For example: freckles, age spots, chloasma, sweat spots, black spots of the areola pigmentation, melanin precipitation in the privacy.
造成皮膚黑色素沉澱的因素很多，有遺傳因素，皮膚老化，皮膚缺氧，過度摩擦，含激素外用藥物後遺症，懷孕，***分泌等多種不同原因。 There are many factors that cause skin melanin precipitation, including genetic factors, skin aging, skin hypoxia, excessive friction, sequelae of hormone-containing topical drugs, pregnancy, and estrogen secretion.
黑色素細胞生成黑色素，主要發生在皮膚表皮的基底層(stratumbasale)隨著新陳代謝的作用，漸漸推向有棘層、顆粒層、透明層和最終運至表皮最外層的角質層。 Melanocytes produce melanin, which occurs mainly in the basal layer of the skin epidermis (stratumbasale), and gradually pushes to the stratum corneum with spinous layer, granular layer, transparent layer and finally transported to the outermost layer of the epidermis.
而市售的美白產品都是液態，膏狀，乳液為主，由於分子量過大要達到表皮基底層非常困難，這就是為什麼美白效果不彰的主要原因，目前去除黑色素的方法還包括外科手術的方式，採用鐳射去除黑色素，但也存在一定的風險，如果鐳射打到真皮，容易對皮膚造成永久性創傷。 The commercially available whitening products are mainly liquid, paste, and emulsion. It is very difficult to reach the basal layer of the epidermis because the molecular weight is too large. This is the main reason why the whitening effect is not good. The current method of removing melanin also includes the surgical method. Laser is used to remove melanin, but there is also a certain risk. If the laser hits the dermis, it will cause permanent trauma to the skin.
為解決現有技術存在的不足，本發明提供一種美白效果好、安全的氣態皮膚供氧美白產品，即成為本發明在此欲解決的一重要課題。 In order to solve the deficiencies of the prior art, the present invention provides a gaseous skin oxygen supply whitening product with good whitening effect and safety, which is an important subject to be solved by the present invention.
本發明提供一種美白效果好、安全的氣態皮膚供氧美白產品，該產品可以和人體分泌的汗液等體液中的水分反應，生成氧氣和活性氧，本發明除了提供皮膚健康呼吸所需的氧氣，同時提供皮膚美白功能的氣體活性氧，包括超氧化氫(HOO-)、超氧陰離子，過氧氫游離基(HOO．)，由於活性氧氣體分子量非常小，直徑約為1nm左右，因此能通過表皮層的皮膚空隙(表皮皮膚空隙直徑為200nm~80000nm)，達到皮膚基底層並與黑色素作用，使黑色素變淺甚至透明。 The invention provides a gaseous skin oxygen supply whitening product with good whitening effect and safety, which can react with moisture in a body fluid such as sweat secreted by the human body to generate oxygen and active oxygen, and the present invention provides oxygen required for healthy skin breathing, At the same time, it provides gas reactive oxygen for skin whitening function, including superhydrogen peroxide (HOO - ), superoxide anion, and hydrogen peroxide radical (HOO.). Since the molecular weight of active oxygen gas is very small, the diameter is about 1 nm, so it can pass. The skin space of the epidermis (the skin void diameter of the epidermis is 200nm~80000nm) reaches the basal layer of the skin and acts with melanin to make the melanin lighter or even transparent.
為解決上述技術問題，本發明的目的即在於提供一種具有皮膚美白功能的供氧材料，該有皮膚美白功能的供氧材料包含固體氧源、活化劑、催化劑；其中固體氧源係選自於由過氧化物與過碳酸物所組成的群組。 In order to solve the above problems, an object of the present invention is to provide an oxygen supply material having a skin whitening function, wherein the oxygen supply material having a skin whitening function comprises a solid oxygen source, an activator, and a catalyst; wherein the solid oxygen source is selected from the group consisting of A group consisting of a peroxide and a percarbonate.
為達前述發明目的，其中該活化劑係為醯基化合物。 For the purpose of the foregoing invention, the activator is a mercapto compound.
為達前述發明目的，其中該過氧化物係選自於由過氧化鈣、過氧化鎂、過氧化鈉、過氧化鉀、過碳酸鈉和過碳酸鈣所組成的群組。 For the purpose of the foregoing invention, the peroxide is selected from the group consisting of calcium peroxide, magnesium peroxide, sodium peroxide, potassium peroxide, sodium percarbonate and calcium percarbonate.
為達前述發明目的，其中該醯基化合物係選自於由四乙醯乙二胺(TAED)、壬醯氧基苯磺酸鈉(NOBS)、四乙醯甘脲、五乙醯葡萄糖、N-乙醯基鄰苯二甲醯亞胺、1-乙醯乙基苯甲酸酯、三乙醯基乙醇胺和壬醯乙醯苯酯磺酸鹽所組成的群組。 For the purpose of the foregoing invention, wherein the mercapto compound is selected from the group consisting of tetraethylamethylenediamine (TAED), sodium decyloxybenzenesulfonate (NOBS), tetraethylglucamine, pentaerythritol, N, a group consisting of acetyl phthalimide, 1-ethyl cyanoethyl benzoate, triethyl hydrazinoethanolamine and acetophenone sulfonate.
為達前述發明目的，其中該催化劑係為過氧化氫酶。 For the purposes of the foregoing invention, the catalyst is catalase.
為達前述發明目的，其中該活化劑與該固體氧源之質量比為0.5：100~10：100；其中該催化劑與該固體氧源之質量比為0.5：100~5：100。 For the purpose of the foregoing invention, the mass ratio of the activator to the solid oxygen source is from 0.5:100 to 10:100; wherein the mass ratio of the catalyst to the solid oxygen source is from 0.5:100 to 5:100.
為達前述發明目的，其中該活化劑與該固體氧源之較佳質量比為2：100~3：100；其中該催化劑與該固體氧源源較佳質量比為1.5：100~2.5：100。 For the purpose of the foregoing invention, a preferred mass ratio of the activator to the solid oxygen source is from 2:100 to 3:100; wherein the mass ratio of the catalyst to the solid oxygen source is from 1.5:100 to 2.5:100.
為達前述發明目的，其中該有皮膚美白功能的供氧材料可進一步加入檸檬酸，其中該檸檬酸該固體氧源之質量比為5~8：2~5。 For the purpose of the foregoing invention, the oxygen supply material having the skin whitening function may further be added with citric acid, wherein the mass ratio of the solid oxygen source of the citric acid is 5-8:2-5.
為達前述發明目的，其中該有皮膚美白功能的供氧材料之粒徑為2000目-2mm。 For the purpose of the foregoing invention, the oxygen supply material having the skin whitening function has a particle diameter of from 2000 mesh to 2 mm.
為達前述發明目的，該有皮膚美白功能的供氧材料可以置於生活衛生用品中，該生活衛生用品係包含口罩、面罩、面膜、胸罩、胸貼、溢乳貼、衛生巾、紙尿褲、衛生護墊、一次性衛生用品、創可貼、包紮紗布、盒型容器。 For the purpose of the foregoing invention, the oxygen supply material having skin whitening function can be placed in a sanitary product including a mask, a mask, a mask, a bra, a chest patch, a diaper paste, a sanitary napkin, a diaper, and a sanitary guard. Pads, disposable hygiene products, band-aids, bandage gauze, box-type containers.
本發明之另一目的為提供一種供給氧氣的皮膚美白結構，該美白結構係以透氣材質包裹如申請專利範圍第1~10項所述之有皮膚美白功能的供氧材料，其中該有皮膚美白功能的供氧材料之粒徑為2000目-2mm，其中該透氣材質具有可以讓氣體透過的小孔，該小孔的直徑小於該有皮膚美白功能的供氧材料之粒徑。 Another object of the present invention is to provide a skin whitening structure for supplying oxygen, which is coated with a gas permeable material such as a skin whitening function as described in claims 1 to 10, wherein the skin whitening is provided. The functional oxygen supply material has a particle size of 2000 mesh to 2 mm, wherein the gas permeable material has a small hole through which gas can pass, and the diameter of the small hole is smaller than the particle diameter of the oxygen supply material having the skin whitening function.
1‧‧‧內芯 1‧‧‧ core
2‧‧‧內層 2‧‧‧ inner layer
3‧‧‧外層 3‧‧‧ outer layer
4‧‧‧功能單元 4‧‧‧Functional unit
5‧‧‧外包覆層 5‧‧‧Overcoat
第1圖係為一種具有緩釋活性氧和氧氣的具有皮膚美白功能的供氧材料結構示意圖。 Figure 1 is a schematic view showing the structure of an oxygen supply material having a skin whitening function with a sustained release of active oxygen and oxygen.
第2圖係為功能單元位於內芯內側表面的結構示意圖；第3圖係為功能單元位於內芯外側表面的結構示意圖；第4圖係為功能單元位於內芯之間的結構示意圖； Figure 2 is a schematic view showing the structure of the functional unit on the inner side surface of the inner core; Fig. 3 is a structural schematic view showing the functional unit on the outer surface of the inner core; and Fig. 4 is a schematic structural view showing the functional unit between the inner core;
本發明係以下面的實施例予以示範闡明，但本發明不受下述實施例所限制。 The present invention is exemplified by the following examples, but the present invention is not limited by the following examples.
如圖1、圖2、圖3所示，一種具有緩釋活性氧和氧氣的具有皮膚美白功能的供氧材料結構，包括內芯1和外包覆層5，內芯1用於固定具有皮膚美白功能的供氧材料的功能單元4，內芯1為吸水材質，外包覆層5用於包覆內芯1；功能單元4可均勻分佈在內芯1的內側表面，功能單元4可均勻分佈在內芯1的外側表面，功能單元4也可均勻分佈在內芯1之間。外包覆層5包括內層2和外層3，內層2為親膚材質的透氣結構，外層3可為透氣材質和不透氣材質，為了使得緩釋活性氧和氧氣的效果更佳，作為優選的，外層3為不透氣材質。功能單元4由固體氧源、催化劑、活化劑混合而成。 As shown in FIG. 1 , FIG. 2 and FIG. 3 , an oxygen supply material structure having a skin whitening function with a sustained release of active oxygen and oxygen, comprising an inner core 1 and an outer cladding layer 5 for fixing the skin The function unit 4 of the whitening function oxygen supply material, the inner core 1 is a water absorbing material, the outer cladding layer 5 is used to cover the inner core 1; the functional unit 4 can be evenly distributed on the inner side surface of the inner core 1, and the functional unit 4 can be evenly distributed. Distributed on the outer side surface of the inner core 1, the functional unit 4 can also be evenly distributed between the inner cores 1. The outer cover layer 5 includes an inner layer 2 and an outer layer 3, and the inner layer 2 is a gas permeable structure of a skin-friendly material, and the outer layer 3 may be a gas permeable material and a gas-impermeable material, and is preferably used for better effect of slow release of active oxygen and oxygen. The outer layer 3 is airtight. The functional unit 4 is a mixture of a solid oxygen source, a catalyst, and an activator.
一種具有皮膚美白功能的供氧材料之配方組合Formulation combination of oxygen supply material with skin whitening function
具有皮膚美白功能的供氧材料，由固體氧源過氧化鈣、催化劑過氧化氫酶、活化劑四乙醯基乙二胺、混合而成美白配方1；其中該過氧化氫酶與過氧化鈣的質量比為1：200；其中該四乙醯基乙二胺與過氧化鈣的質量比為1：200；其中該具有皮膚美白功能的供氧材料，粒徑為60目。 An oxygen supply material having skin whitening function, which is composed of a solid oxygen source calcium peroxide, a catalyst catalase, an activator tetraethylene ethylenediamine, and a whitening formula 1; wherein the catalase and calcium peroxide The mass ratio is 1:200; wherein the mass ratio of the tetraethylenethiodiamine to the calcium peroxide is 1:200; wherein the oxygen supply material having a skin whitening function has a particle size of 60 mesh.
將固體氧源過氧化鈣(CaO2)與催化劑過氧化氫酶(CAT)及活化劑四乙醯基乙二胺(TAED)均勻混合，利用皮膚排出之水份(汗液)或體液(尿液或血液)，或以空氣中的水份(濕度)與上述具有皮膚美白功能的供氧材料作用，或另備水性液體在使用時與具有皮膚美白功能的供氧材料作用。 The solid oxygen source calcium peroxide (CaO 2 ) is uniformly mixed with the catalyst catalase (CAT) and the activator tetraethylene ethylenediamine (TAED), and the water (sweat) or body fluid (urine) discharged from the skin is utilized. Or blood), or the moisture (humidity) in the air acts with the oxygen supply material having the skin whitening function described above, or the additional aqueous liquid acts on the oxygen supply material having the skin whitening function when in use.
其反應式為CaO2+H2O→Ca(OH)2+O2；上述反應中間產物過氧化氫(H2O2)像弱酸一樣，在鹼性介質中離解為過氧化氫負離子。 The reaction formula is CaO 2 +H 2 O→Ca(OH) 2 +O 2 ; the above reaction intermediate hydrogen peroxide (H 2 O 2 ) dissociates into a hydrogen peroxide anion in an alkaline medium like a weak acid.
H2O2+OH- → HOO-+H2O H 2 O 2 +OH - → HOO - +H 2 O
過氧化氫負離子是一種親核試劑，具有引發過氧化氫形成游離基的作用；HOO-+H2O2 → HOO．+HO．+OH- Hydrogen peroxide anion is a nucleophilic reagent that initiates the formation of free radicals by hydrogen peroxide; HOO - + H 2 O 2 → HOO. +HO. +OH -
兩者都有較高的活性，可使色素氧化分解而產生漂白作用。 Both have higher activity, which can oxidize and decompose the pigment to produce bleaching effect.
所產生的氣態活性氧，在被包覆的環境下可保持較高的活性氧氣體濃度。 The gaseous active oxygen produced maintains a high concentration of active oxygen gas in the coated environment.
美白配方2：由固體氧源過氧化鈣、催化劑過氧化氫酶、活化劑四乙醯基乙二胺混合而成，在美白配方1的基礎上，改變催化劑和活化劑的添加量，其中該過氧化氫酶與過氧化鈣的質量比為1：50；其中該四乙醯基乙二胺與過氧化鈣的質量比為1：40。 Whitening Formulation 2: a mixture of a solid oxygen source calcium peroxide, a catalyst catalase, and an activator tetraethylene ethylenediamine. On the basis of whitening formula 1, the amount of catalyst and activator added is changed, wherein The mass ratio of catalase to calcium peroxide is 1:50; wherein the mass ratio of the tetraethyleneethylenediamine to the calcium peroxide is 1:40.
美白配方3：由固體氧源過氧化鈣、催化劑過氧化氫酶、活化劑四乙醯基乙二胺混合而成，在為美白配方1的基礎上，改變催化劑和活化劑的添加量，其中該過氧化氫酶與過氧化鈣的質量比為1：20；其中該四乙醯基乙二胺與過氧化鈣的質量比為1：10。 Whitening Formulation 3: a mixture of a solid oxygen source calcium peroxide, a catalyst catalase, and an activator tetraethylene ethylenediamine. On the basis of the whitening formula 1, the amount of the catalyst and the activator is changed, wherein The mass ratio of the catalase to the calcium peroxide is 1:20; wherein the mass ratio of the tetraethyleneethylenediamine to the calcium peroxide is 1:10.
美白配方4：由固體氧源過氧化鈣、催化劑過氧化氫酶、活化劑四乙醯基乙二胺與檸檬酸混合而成，在為美白配方2的基礎 上，增加檸檬酸，其中該過氧化氫酶與過氧化鈣的質量比為1：50；其中該四乙醯基乙二胺與過氧化鈣的質量比為1：40；其中該檸檬酸與過氧化鈣的質量比為7：4。 Whitening Formulation 4: a mixture of solid oxygen source calcium peroxide, catalyst catalase, activator tetraethylene ethylenediamine and citric acid. On the basis of whitening formula 2, citric acid is added. The mass ratio of the catalase to the calcium peroxide is 1:50; wherein the mass ratio of the tetraethylenethiodiamine to the calcium peroxide is 1:40; wherein the mass ratio of the citric acid to the calcium peroxide is 7: 4.
美白配方5：在美白配方2的基礎上，改變固體氧源和活化劑的種類和產品粒徑，其中該固體氧源為過氧化鎂；其中該活化劑為壬醯氧基苯磺酸鈉；所述產品粒徑為2000目。 Whitening formula 5: on the basis of whitening formula 2, changing the type of solid oxygen source and activator and product particle size, wherein the solid oxygen source is magnesium peroxide; wherein the activator is sodium decyl benzene sulfonate; The product has a particle size of 2000 mesh.
美白配方6：在美白配方2的基礎上，改變固體氧源和活化劑的種類，其中該固體氧源為過氧化鈉；其中該活化劑為四乙醯甘脲。 Whitening Formulation 6: On the basis of Whitening Formulation 2, the type of solid oxygen source and activator is changed, wherein the solid oxygen source is sodium peroxide; wherein the activator is tetraethylene glycoluril.
美白配方7：在美白配方2的基礎上，改變固體氧源和活化劑的種類和產品粒徑，其中該固體氧源為過氧化鉀；其中該活化劑為五乙醯葡萄糖；其中該產品粒徑為2mm。 Whitening Formulation 7: On the basis of Whitening Formulation 2, changing the type of solid oxygen source and activator and the particle size of the product, wherein the solid oxygen source is potassium peroxide; wherein the activator is pentaethylene glucose; The diameter is 2mm.
美白配方8：在美白配方2的基礎上，改變固體氧源和活化劑的種類，其中該固體氧源為過碳酸鈉；其中該活化劑為N-乙醯基鄰苯二甲醯亞胺。 Whitening Formulation 8: On the basis of Whitening Formulation 2, the type of solid oxygen source and activator is changed, wherein the solid oxygen source is sodium percarbonate; wherein the activator is N-acetyl phthalimide.
美白配方9：在美白配方2的基礎上，改變固體氧源和活化劑的種類，其中該固體氧源為過碳酸鈣；其中該活化劑為1-乙醯乙基苯甲酸酯。 Whitening Formulation 9: On the basis of Whitening Formulation 2, the type of solid oxygen source and activator is changed, wherein the solid oxygen source is calcium percarbonate; wherein the activator is 1-ethylidene ethyl benzoate.
美白配方10：在美白配方2的基礎上，改變活化劑的種類，其中該活化劑為三乙醯基乙醇胺。 Whitening Formulation 10: On the basis of Whitening Formulation 2, the type of activator is changed, wherein the activator is triethylethanolamine.
美白配方11：在美白配方2的基礎上，改變活化劑的種類， 其中該活化劑為壬醯乙醯苯酯磺酸鹽。 Whitening Formulation 11: On the basis of Whitening Formulation 2, the type of activator is changed, wherein the activator is acetophenone sulfonate.
對照組1：由固體氧源過氧化鈣、催化劑過氧化氫酶、活化劑四乙醯基乙二胺混合而成，在為美白配方1的基礎上，改變催化劑和活化劑的添加量，其中該過氧化氫酶與過氧化鈣的質量比為1：250；其中該四乙醯基乙二胺與過氧化鈣的質量比為11：100 Control group 1: a mixture of solid oxygen source calcium peroxide, catalyst catalase, and activator tetraethylene ethylenediamine. On the basis of whitening formula 1, the amount of catalyst and activator added was changed. The mass ratio of the catalase to the calcium peroxide is 1:250; wherein the mass ratio of the tetraethyleneethylenediamine to the calcium peroxide is 11:100
對照組2：由固體氧源過氧化鈣、催化劑過氧化氫酶、活化劑四乙醯基乙二胺混合而成，在為美白配方1的基礎上，改變催化劑和活化劑的添加量，其中該過氧化氫酶與過氧化鈣的質量比為5.5：100；其中該四乙醯基乙二胺與過氧化鈣的質量比為1：250。 Control group 2: a mixture of solid oxygen source calcium peroxide, catalyst catalase, and activator tetraethylene ethylenediamine. On the basis of whitening formula 1, the amount of catalyst and activator added was changed. The mass ratio of the catalase to the calcium peroxide is 5.5:100; wherein the mass ratio of the tetraethyleneethylenediamine to the calcium peroxide is 1:250.
對照組3：由固體氧源過氧化鈣、催化劑過氧化氫酶混合而成，在美白配方2的基礎上，去掉四乙醯基乙二胺，其中該過氧化氫酶占過氧化鈣的品質百分比為2%。 Control group 3: a mixture of solid oxygen source calcium peroxide and catalyst catalase. On the basis of whitening formula 2, tetraethyl decyl ethylenediamine was removed, wherein the catalase accounted for the quality of calcium peroxide. The percentage is 2%.
對照組4：只採用固體氧源過氧化鈣。 Control group 4: Only a solid oxygen source of calcium peroxide was used.
實施例1 一種具有皮膚美白功能的供氧材料於衛生棉的應用Example 1 Application of an oxygen supply material having skin whitening function to sanitary napkins
衛生棉包括內芯和外包覆層，內芯用於固定功能性成分，功能性成分可均勻分佈在內芯的內側表面，也可均勻分佈在內芯1的外側表面，也可均勻分佈在內芯之間。 The sanitary napkin comprises an inner core and an outer covering layer, and the inner core is used for fixing functional components, and the functional components can be evenly distributed on the inner side surface of the inner core, or evenly distributed on the outer side surface of the inner core 1, or evenly distributed Between the cores.
外包覆層包括內層和外層，內層為親膚材質的透氣結構，外層可為透氣材質和不透氣材質，為了使得緩釋活性氧和氧氣的效果更佳，作為優選的，外層為不透氣材質，其他製備工藝採用現有技術。 The outer cover layer comprises an inner layer and an outer layer, the inner layer is a gas permeable structure of a skin-friendly material, and the outer layer is a gas permeable material and a gas-impermeable material, and in order to make the effect of slow release of active oxygen and oxygen better, preferably, the outer layer is not Breathable material, other preparation processes using the prior art.
其中該功能性成分分別採用美白配方1-4、對照組1-2所述的粉末，製 備成不同種類的衛生棉；功能性成分添加量為1-1.2g/片。 The functional ingredients were prepared into different types of sanitary napkins by using the powders described in the whitening formula 1-4 and the control group 1-2, respectively; the functional ingredient was added in an amount of 1-1.2 g/tablet.
實驗方法：招募600名志願者，試用本發明和對比例的衛生棉，志願者24小時不間斷使用該衛生棉(短時間洗浴等可忽略不計)，使用2個月後，各自獨立填寫評估問卷，志願者年齡為35-50歲，平均分成6組：效果評價：無效：私處皮膚的顏色無明顯變化；有效：私處的皮膚黑色素沉積的程度減少50%以下，黑色素沉積的面積減小30%以下；皮膚光滑有彈性，異味減輕；非常有效：私處的皮膚顏色明顯變淺，黑色素沉積的程度減少50%以上，黑色素面積減少30%以上；皮膚光滑有彈性，基本無異味。 Experimental method: 600 volunteers were recruited to try the sanitary napkins of the present invention and the comparative examples, and the volunteers used the sanitary napkins 24 hours a day without interruption (short-time bathing and the like were negligible), and after 2 months of use, the questionnaires were independently filled out. Volunteers aged 35-50 years, divided into 6 groups on average: effect evaluation: invalid: no change in the color of the skin of the private parts; effective: the degree of melanin deposition in the private parts of the skin is reduced by 50% or less, and the area of melanin deposition is reduced by 30%. Below; the skin is smooth and elastic, and the odor is relieved; very effective: the skin color of the private parts is obviously lighter, the degree of melanin deposition is reduced by more than 50%, the area of melanin is reduced by more than 30%; the skin is smooth and elastic, and basically has no odor.
實施例2 一種具有皮膚美白功能的供氧材料於胸貼的應用胸貼包括內芯和外包覆層，內芯用於固定功能性成分，功能性成分可均勻分佈在內芯的內側表面，也可均勻分佈在內芯1的外側表面，也可均勻分佈在內芯之間。 Embodiment 2 An application of an oxygen supply material having a skin whitening function to a chest patch includes an inner core and an outer cover layer, the inner core is used for fixing a functional component, and the functional component is evenly distributed on the inner side surface of the inner core. It can also be evenly distributed on the outer surface of the inner core 1, or evenly distributed between the inner cores.
外包覆層包括內層和外層，內層為親膚材質的透氣結構，外層可為透氣材質和不透氣材質，為了使得緩釋活性氧和氧氣的效果更佳，作為優選的，外層為不透氣材質，其他製備工藝採用現有技術。 The outer cover layer comprises an inner layer and an outer layer, the inner layer is a gas permeable structure of a skin-friendly material, and the outer layer is a gas permeable material and a gas-impermeable material, and in order to make the effect of slow release of active oxygen and oxygen better, preferably, the outer layer is not Breathable material, other preparation processes using the prior art.
其中該功能性成分分別採用美白配方1-4、對照組1-2所述粉末，製備成不同種類的胸貼；功能性成分添加量為0.3-0.5g/片。 The functional ingredients were prepared by using the powders of the whitening formula 1-4 and the control group 1-2, respectively, to prepare different types of chest stickers; the functional ingredients were added in an amount of 0.3-0.5 g/tablet.
實驗方法：招募600名女性志願者，試用本發明和對比例的胸貼，600名女性均有妊娠經歷，存在乳暈、乳頭發黑的現象；志願者24小時不間斷使用該胸貼(短時間洗浴等可忽略不計)，使用15天後，各自獨立填寫評估問卷，志願者年齡為30-45歲，平均分成6組。 Experimental method: 600 female volunteers were recruited to try the chest stickers of the present invention and the comparative example. 600 women had pregnancy experience, and there were appearances of areola and milk hair. The volunteers used the chest stickers 24 hours a day (short time) Bathing and so on can be ignored. After 15 days of use, the questionnaires were independently filled out. The volunteers were 30-45 years old and divided into 6 groups.
效果評價：無效：乳暈、乳頭皮膚顏色無明顯變化；有效：乳暈直徑減小30%以下；乳暈顏色變淺50%以下；乳頭頂部顏色變淺50%以下；乳頭側面顏色變淺15%以下；非常有效：乳暈直徑減小30%以上；乳暈顏色變淺50%以上；乳頭頂部顏色變淺50%以上；乳頭側面顏色變淺15%以上，乳暈和乳頭頂部顏色 呈現肉粉色(未懷孕前的女性顏色為該顏色) Effect evaluation: Ineffective: no obvious change in the color of the areola and nipple skin; effective: the diameter of the areola is reduced by 30% or less; the color of the areola is less than 50%; the color of the top of the nipple is less than 50%; the color of the side of the nipple is less than 15%; Very effective: the areola diameter is reduced by more than 30%; the areola color is lighter than 50%; the top of the nipple is lighter than 50%; the color of the nipple is lighter than 15%, and the color of the areola and the top of the nipple is pink (not before pregnancy) Female color is the color)
實施例3 一種具有皮膚美白功能的供氧材料於面罩的應用Example 3 Application of an oxygen supply material with skin whitening function to a mask
面罩包括內芯和外包覆層，內芯用於固定功能性成分，功能性成分可均勻分佈在內芯的內側表面，也可均勻分佈在內芯1的外側表面，也可均勻分佈在內芯之間。 The mask comprises an inner core and an outer covering layer, the inner core is used for fixing the functional component, the functional component can be evenly distributed on the inner side surface of the inner core, or evenly distributed on the outer side surface of the inner core 1, or evenly distributed Between the cores.
外包覆層包括內層和外層，內層為親膚材質的透氣結構，外層可為透氣材質和不透氣材質，為了使得緩釋活性氧和氧氣的效果更佳，作為優選的，外層為不透氣材質，其他製備工藝採用現有技術。 The outer cover layer comprises an inner layer and an outer layer, the inner layer is a gas permeable structure of a skin-friendly material, and the outer layer is a gas permeable material and a gas-impermeable material, and in order to make the effect of slow release of active oxygen and oxygen better, preferably, the outer layer is not Breathable material, other preparation processes using the prior art.
其中該功能性成分分別採用美白配方1-4、對照組1-2所述粉末，製備成不同種類的面罩；功能性成分添加量為0.6-0.8g/片。 The functional ingredients were prepared by using the powders of the whitening formula 1-4 and the control group 1-2, respectively, to prepare different types of masks; the functional ingredients were added in an amount of 0.6-0.8 g/tablet.
實驗方法：招募150名女性志願者，平均分成6組，試用本發明和對比例的面罩，志願者年齡為70-80歲，150名女性均存在嚴重的老年斑。 Experimental method: 150 female volunteers were recruited and divided into 6 groups. The masks of the present invention and the comparative examples were tried. The volunteers were 70-80 years old, and 150 females had severe senile plaques.
志願者24小時不間斷使用該面罩(短時間洗浴、吃飯等可忽略不計)，使用15天後，各自獨立填寫評估問卷。 The volunteers used the mask 24 hours a day (short-time bathing, eating, etc. negligible), and after 15 days of use, they independently filled out the evaluation questionnaire.
效果評價： Evaluation:
無效：老年斑的面積、顏色均無顯著變化 Invalid: no significant changes in the area and color of age spots
有效：老年斑的顏色變淺50%以下；面積減少30%以下；非常有效：老年斑的顏色變淺50%以上，面積減少30%以上； Effective: the color of age spots is less than 50%; the area is reduced by 30% or less; very effective: the color of age spots is lighter than 50%, and the area is reduced by more than 30%;
從表3的結果可見，活化劑四乙醯基乙二胺(TAED)的介入可在常溫環境獲得更多的活性氧HO2 -，獲得更好的美白效果。 From the results of Table 3, it can be seen that the intervention of the activator tetraethyleneethylenediamine (TAED) can obtain more active oxygen HO 2 - at room temperature, and obtain a better whitening effect.
實施例4 一種具有皮膚美白功能的供氧材料在醫用敷料中的應用Example 4 Application of an oxygen supply material with skin whitening function in medical dressings
當皮膚受到外傷時，在傷口處因外力導致皮膚破損並傷害到真皮層，由於微血管被破壞直接影響了血液供氧至傷口的能力，此時皮膚的癒合因為缺氧而導致癒合週期延長，同時傷口癒合過程亦有可能伴隨黑色素的沉澱形成色斑，甚至引起厭氧菌的感染。 When the skin is traumatized, the skin is damaged by the external force and damages the dermis layer. The damage of the microvascular is directly affected by the ability of the blood to supply oxygen to the wound. At this time, the healing of the skin is delayed due to lack of oxygen, and the healing cycle is prolonged. The wound healing process may also be accompanied by the precipitation of melanin to form stains and even cause anaerobic infection.
在醫用敷料(創可貼，包紮用無紡布)夾層中置入本發明美白配方2所述的產氧配方，提供傷口氧氣幫助傷口癒合，同時可預防皮膚黑色素堆積形成色素班，更可抑制厭氧菌的繁殖與感染。 The oxygen-producing formula described in the whitening formula 2 of the present invention is placed in the interlayer of the medical dressing (band-aid, non-woven fabric for wrapping) to provide wound oxygen to help the wound heal, and at the same time prevent the melanin accumulation of the skin to form a pigment class, and more inhibit the skin. Breeding and infection of oxygen bacteria.
上述具有皮膚美白功能的供氧材料在應用時以透氣容器包覆；其中該透氣容器，為透氣網狀面料結構，一方面對包覆的皮膚提供活性氧源，又能裝載本發明所述美白產品於夾層之中，並以透氣網狀面料結構與皮膚之間形成一微小空間，而粉末並不直接接觸皮膚。所述透氣容器為口罩，面罩，面膜，胸罩，胸貼，溢乳貼，衛生棉，紙尿褲，衛生護墊，一次性衛生用品，創可貼，包紮紗布，盒型容器中的一種。本發明產品以盒型容器為載體時，可以將粉末置入盒內以透氣材質(無紡布，紗布)包覆容器封合使用，用上述包覆容器的夾層裝載粉末，使粉末與皮膚隔離，形成 結構外層與皮膚之間有一微小空間，以利儲存活性氧並保持適當濃度，對皮膚持續提供氣態美白活性氧。 The oxygen supply material having the skin whitening function is coated with a gas permeable container when applied; wherein the gas permeable container is a gas permeable mesh fabric structure, on the one hand, the active oxygen source is provided to the coated skin, and the whitening of the invention can be loaded. The product is in the interlayer and forms a tiny space between the breathable mesh structure and the skin, and the powder does not directly contact the skin. The ventilating container is a mask, a mask, a mask, a bra, a chest sticker, a nipple paste, a sanitary napkin, a diaper, a sanitary pad, a disposable sanitary product, a band-aid, a bandage gauze, and a box type container. When the product of the invention is used as a carrier for the box type container, the powder can be placed in the box and sealed with a gas permeable material (non-woven fabric, gauze) coated container, and the powder is loaded with the interlayer of the above-mentioned coated container to isolate the powder from the skin. There is a tiny space between the outer layer of the structure and the skin to store the active oxygen and maintain an appropriate concentration to continuously provide gaseous whitening active oxygen to the skin.
上述具有皮膚美白功能的供氧材料，為顆粒或粉末狀或者將粉末壓縮成一體；所述產品粒徑為2000目-2mm；上述具有皮膚美白功能的供氧材料的粒徑大於透氣容器的孔徑。其中該具有皮膚美白功能的供氧材料粒徑，優選為40-80目；其中該具有皮膚美白功能的供氧材料粒徑，更優選為60目。 The oxygen supply material having the skin whitening function is in the form of granules or powder or compresses the powder into one body; the product has a particle size of 2000 mesh to 2 mm; and the particle diameter of the oxygen supply material having the skin whitening function is larger than the diameter of the gas permeable container . The particle diameter of the oxygen supply material having a skin whitening function is preferably 40-80 mesh; wherein the particle diameter of the oxygen supply material having a skin whitening function is more preferably 60 mesh.
上述具有皮膚美白功能的供氧材料在除成人紙尿褲的透氣容器中應用時，使用量為0.3-2g/件；上述具有皮膚美白功能的供氧材料在成人紙尿褲中使用時，使用量較大，為1-10g。 The oxygen supply material having the skin whitening function is used in a gas permeable container other than an adult diaper, and the amount of use is 0.3-2 g/piece; when the oxygen supply material having the skin whitening function is used in an adult diaper, the amount of use is large. It is 1-10g.
與現有技術相比，本發明的有益效果如下：Compared with the prior art, the beneficial effects of the present invention are as follows:
(1)本發明所述之具有皮膚美白功能的供氧材料，在衛生棉中應用，能夠對女性的私處皮膚進行美白，私處的皮膚黑色素沉積明顯減少，黑色素沉積的面積減小；皮膚光滑有彈性，異味減輕；總有效率為94-100%；(2)本發明所述之具有皮膚美白功能的供氧材料，在胸貼中的應用，具有美白胸部皮膚的效果，乳暈、乳頭的顏色明顯變淺，由黑褐色向肉粉色轉變；總有效率為94-99%；(3)本發明所述之具有皮膚美白功能的供氧材料，在面罩中的應用，老年斑的面積明顯減少，顏色明顯變淺，總有效率為93-100%；(4)本發明所述之具有皮膚美白功能的供氧材料，在醫用敷料(創可貼，包紮用無紡布)夾層中應用，提供傷口氧氣幫助傷口癒合，同時可預防皮膚黑色素堆積形成色素班，更可抑制厭氧菌的繁殖與感染。 (1) The oxygen supply material having skin whitening function according to the present invention is applied to sanitary napkins, and can whiten the skin of a woman's private parts, the melanin deposition of the skin of the private parts is significantly reduced, the area of melanin deposition is reduced, and the skin is smooth. The elasticity and the odor are alleviated; the total effective rate is 94-100%; (2) the oxygen supply material with skin whitening function according to the invention has the effect of whitening the chest skin, the color of the areola and the nipple. Significantly lighter, from dark brown to flesh pink; total effective rate is 94-99%; (3) the oxygen supply material with skin whitening function according to the present invention, the application of the mask, the area of the age spots is significantly reduced, The color is obviously lighter, and the total effective rate is 93-100%; (4) The oxygen supply material with skin whitening function according to the present invention is applied in the interlayer of medical dressing (band-aid, wrapping non-woven fabric) to provide wound Oxygen helps the wound heal, while preventing the accumulation of melanin in the skin to form a pigment class, which also inhibits the reproduction and infection of anaerobic bacteria.
上列詳細說明係針對本發明之可行實施例之具體說明，惟該實施例並非用以限制本發明之專利範圍，凡未脫離本發明技藝精神所為之等效實施或變更，均應包含於本案之專利範圍中。 The detailed description of the preferred embodiments of the present invention is not intended to limit the scope of the present invention, and the equivalent implementations or modifications of the present invention should be included in the present invention. In the scope of patents.
上述多項功效，實屬充分符合新穎性及進步性之法定專利要件，爰依法提出申請，懇請 貴局核准本件發明專利申請案，以勵發明。 The above-mentioned multiple functions are the statutory patent requirements that fully meet the novelty and progressiveness. If you apply in accordance with the law, you are requested to approve the application for the invention patent to encourage the invention.
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| US5466391A (en) * | 1994-06-21 | 1995-11-14 | Genox Co. Ltd. | Granulated agent and catalyst used for oxygen generation |
| US20070166339A1 (en) * | 2003-04-18 | 2007-07-19 | Bioderm Research | Skin Whitening Methods and Compositions Based on Zeolite - Active Oxygen Donor Complexes |
| US20090142281A1 (en) * | 2005-10-21 | 2009-06-04 | Thomas Rand | Composition Comprising A Coupled Enzyme System |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI714937B (en) * | 2019-01-04 | 2021-01-01 | 瀚綺生物科技有限公司 | Gas-water mixer and foot bath including the same |
Also Published As
| Publication number | Publication date |
|---|---|
| TW201815375A (en) | 2018-05-01 |
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