TWI630436B - Contact lens material and contact lens - Google Patents

Contact lens material and contact lens Download PDF

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Publication number
TWI630436B
TWI630436B TW104139039A TW104139039A TWI630436B TW I630436 B TWI630436 B TW I630436B TW 104139039 A TW104139039 A TW 104139039A TW 104139039 A TW104139039 A TW 104139039A TW I630436 B TWI630436 B TW I630436B
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contact lens
polymer
hydrogen peroxide
peroxide solution
nanocapsule
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TW104139039A
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TW201719242A (en
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簡秀紋
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鴻海精密工業股份有限公司
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Priority to US14/969,878 priority patent/US9891348B2/en
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    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B1/00—Optical elements characterised by the material of which they are made; Optical coatings for optical elements
    • G02B1/04—Optical elements characterised by the material of which they are made; Optical coatings for optical elements made of organic materials, e.g. plastics
    • G02B1/041—Lenses
    • G02B1/043—Contact lenses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/446—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with other specific inorganic fillers other than those covered by A61L27/443 or A61L27/46
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/48—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with macromolecular fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/11—Peroxy compounds, peroxides, e.g. hydrogen peroxide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/602—Type of release, e.g. controlled, sustained, slow
    • A61L2300/604—Biodegradation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/62—Encapsulated active agents, e.g. emulsified droplets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/12—Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces

Abstract

一種隱形眼鏡鏡片，包括基體，所述隱形眼鏡鏡片還包括混合於該基體中之聚合物納米膠囊，該聚合物納米膠囊能夠藉由化學反應釋放氧氣。本發明還提供一種用於製備上述隱形眼鏡鏡片之隱形眼鏡鏡片材料。 A contact lens comprising a substrate, the contact lens further comprising a polymer nanocapsule mixed in the matrix, the polymer nanocapsule capable of releasing oxygen by a chemical reaction. The present invention also provides a contact lens material for use in preparing the above contact lens.

Description

隱形眼鏡鏡片材料及隱形眼鏡鏡片 Contact lens material and contact lens

本發明涉及一種隱形眼鏡鏡片材料，以及由該隱形眼鏡鏡片材料製備之隱形眼鏡鏡片。 The present invention relates to a contact lens material, and a contact lens prepared from the contact lens material.

隱形眼鏡基本上分類為軟質型和硬質型眼鏡。其中，軟質隱形眼鏡通常分為水凝膠隱形眼鏡和非水凝膠隱形眼鏡。 Contact lenses are basically classified into soft and hard glasses. Among them, soft contact lenses are generally classified into hydrogel contact lenses and non-hydrogel contact lenses.

常規之軟質水凝膠隱形眼鏡通常由親水性單體(例如甲基丙烯酸羥基乙酯、N-乙烯基吡咯烷酮等)之共聚物組成，且可藉由車床切割方法、旋轉澆築方法、注塑成型方法或其組合，之後藉由於生理鹽水和/或磷酸鹽緩衝溶液中進行溶脹處理以獲得含水量20%-80%(質量百分比)之眼鏡而製成。 Conventional soft hydrogel contact lenses are usually composed of a copolymer of a hydrophilic monomer (such as hydroxyethyl methacrylate, N-vinylpyrrolidone, etc.), and can be processed by a lathe cutting method, a rotary casting method, or an injection molding method. Or a combination thereof, which is then prepared by swelling treatment in physiological saline and/or phosphate buffer solution to obtain glasses having a water content of 20% to 80% by mass.

隱形眼鏡於佩戴時舒適且安全是重要。舉例來說，矽水凝膠隱形眼鏡對於每日使用、佩戴過夜和/或長期連續佩戴之方式佩戴，佩戴時應當是舒適且安全。但是。現如今之隱形眼鏡於佩戴器件會將鏡片粘附到角膜上，由於鏡片之透氧性不高，使得角膜缺氧從而導致佩戴者眼鏡不適、角膜水腫、視力模糊等問題。另外，這類鏡片於夜間佩戴時還容易導致角膜腫脹之問題。 It is important that the contact lens is comfortable and safe to wear. For example, hydrogel contact lenses are worn for everyday use, overnight wear, and/or long-term continuous wear and should be comfortable and safe to wear. but. Nowadays, the contact lens adheres to the cornea in the wearing device. Due to the low oxygen permeability of the lens, the cornea is deficient in oxygen, which causes problems such as discomfort of the wearer's glasses, corneal edema, blurred vision and the like. In addition, such lenses are prone to corneal swelling when worn at night.

鑒於以上內容，有必要提供一種能夠提高透氧性且不易導致角膜腫脹之隱形眼鏡鏡片。 In view of the above, it is necessary to provide a contact lens which is capable of improving oxygen permeability and which is less likely to cause swelling of the cornea.

一種隱形眼鏡鏡片，包括基體，所述隱形眼鏡鏡片還包括混合於該基體中之聚合物納米膠囊，該聚合物納米膠囊能夠藉由化學反應釋放氧氣。 A contact lens comprising a substrate, the contact lens further comprising a polymer nanocapsule mixed in the matrix, the polymer nanocapsule capable of releasing oxygen by a chemical reaction.

一種隱形眼鏡鏡片材料，用以製備隱形眼鏡鏡片，該隱形眼鏡鏡片材料包括由聚合物納米膠囊、親水性單體、水合聚合物、光引發劑以及交聯劑組成之混合物，於紫外光照射下，所述親水性單體和水合聚合物可於光引發劑以及交聯劑之作用下發生共聚反應後形成基體，該聚合物納米膠囊混合於該基體中。 A contact lens material for preparing a contact lens, the contact lens material comprising a mixture of polymer nanocapsules, a hydrophilic monomer, a hydrated polymer, a photoinitiator and a crosslinking agent, under ultraviolet light The hydrophilic monomer and the hydrated polymer may form a matrix after copolymerization by a photoinitiator and a crosslinking agent, and the polymer nanocapsules are mixed in the matrix.

與習知技術相比，上述隱形眼鏡鏡片中之聚合物納米膠囊能夠於基體內藉由化學反應產生氧氣，以提高該隱形眼鏡鏡片之透氧性，並可以為角膜等部位提供必要之氧氣，防止角膜因缺氧而腫脹並對眼睛造成傷害。 Compared with the prior art, the polymer nanocapsules in the above contact lens can generate oxygen by chemical reaction in the matrix to improve the oxygen permeability of the contact lens, and can provide necessary oxygen for the cornea and the like. Prevents the cornea from swelling due to lack of oxygen and causing damage to the eyes.

於下列敘述中，各式特定細節系用以提供本發明實施例之通盤瞭解。本發明將配合其較佳實施例詳述於下，應理解之是本發明中所有較佳實施例僅為例示之用，並非用以限制本發明。熟之該項技術者亦應理解，本發明之實施不須一或多特定細節，或其他特定方法。本發明可以應用於各種隱形眼鏡，以下做一說明。 In the following description, various specific details are set forth to provide a comprehensive understanding of the embodiments of the invention. The present invention will be described in detail with reference to the preferred embodiments thereof. It will be understood by those skilled in the art that the practice of the invention does not require one or more specific details or other specific methods. The present invention can be applied to various contact lenses, and the following description will be made.

本發明之一較佳實施方式用以提供一種隱形眼鏡鏡片，該隱形眼鏡鏡片包括基體及混合於該基體中之聚合物納米膠囊。其中，該聚合物納米膠囊包括過氧化氫(H2O2)溶液及用以包裹該過氧化氫溶液之壁材。該聚合物納米膠囊之壁材能夠於該基體中緩慢分解而釋放出該過氧化氫溶液，該過氧化氫自行分解並釋放出氧氣和水，提高該隱形眼鏡之透氧性，並為角膜等部位提供氧氣和水，從而防止角膜因缺氧而腫脹等問題。進一步於使用該隱形眼鏡鏡片時，於可見光之照射下，該過氧化氫之分解速度加快，從而加快氧氣之釋放速 度。進一步於使用該隱形眼鏡鏡片時，可添加少量之過氧化氫酶，從而促進過氧化氫分解釋放氧氣，從而進一步加快氧氣之釋放速度。另外，由於過氧化氫本身具有消毒功能，從而為該隱形眼鏡鏡片提供消毒功能，防止眼鏡受到納米生物之感染。 A preferred embodiment of the present invention provides a contact lens comprising a substrate and a polymer nanocapsule mixed in the substrate. Wherein, the polymer nanocapsule comprises a hydrogen peroxide (H 2 O 2 ) solution and a wall material for wrapping the hydrogen peroxide solution. The wall material of the polymer nanocapsule can be slowly decomposed in the matrix to release the hydrogen peroxide solution, and the hydrogen peroxide decomposes by itself and releases oxygen and water to improve the oxygen permeability of the contact lens, and is a cornea, etc. The site provides oxygen and water to prevent swelling of the cornea due to lack of oxygen. Further, when the contact lens is used, the decomposition speed of the hydrogen peroxide is accelerated under the irradiation of visible light, thereby accelerating the release rate of oxygen. degree. Further, when the contact lens is used, a small amount of catalase can be added to promote the decomposition of hydrogen peroxide to release oxygen, thereby further accelerating the release rate of oxygen. In addition, since the hydrogen peroxide itself has a disinfecting function, the contact lens is provided with a disinfecting function to prevent the lens from being infected by the nano organism.

於本實施方式中，該聚合物納米膠囊於隱形眼鏡鏡片中所佔之質量百分比為0.01%-5%。 In the present embodiment, the polymer nanocapsules occupy 0.01% to 5% by mass of the contact lens.

於本實施方式中，該聚合物納米膠囊包括過氧化氫溶液及用以包裹該過氧化氫溶液之壁材。其中，該過氧化氫溶液於該聚合物納米膠囊中所佔之質量百分比為0.05%-10%，該過氧化氫溶液中過氧化氫之濃度為1%~35%(質量百分比)。該壁材是可分解之高分子材料。進一步該可分解之高分子材料包含甲殼素、聚乳酸羥基乙酸共聚物(PLGA)、海藻酸鈉、明膠或其他天然或合成之可分解性高分子等。 In this embodiment, the polymer nanocapsule comprises a hydrogen peroxide solution and a wall material for wrapping the hydrogen peroxide solution. Wherein, the hydrogen peroxide solution accounts for 0.05%-10% by mass of the polymer nanocapsule, and the concentration of hydrogen peroxide in the hydrogen peroxide solution is 1%-35% (mass%). The wall material is a decomposable polymer material. Further, the decomposable polymer material comprises chitin, polylactic acid glycolic acid copolymer (PLGA), sodium alginate, gelatin or other natural or synthetic decomposable polymer.

於本實施方式中，該隱形眼鏡鏡片可以是水凝膠鏡片或矽水凝膠鏡片。當該隱形眼鏡鏡片為水凝膠鏡片時，該基體為水凝膠；當該隱形眼鏡鏡片為矽水凝膠鏡片時，該基體為矽水凝膠。其中，所述水凝膠和矽水凝膠均由親水性單體和水合聚合物於光引發劑以及交聯劑之作用下發生共聚反應後形成。其中，所述水合聚合物做為水凝膠和矽水凝膠之主鏈，所述親水性單體作為水凝膠和矽水凝膠中功能性之單體以增加其親水性和透氧性等性能。進一步該親水性單體和水合聚合物於所述隱形眼鏡鏡片中所佔之質量百分比為94%-99.95%。該交聯劑於所述隱形眼鏡鏡片中所佔之質量百分比為0.001%~2%。該引發劑於所述隱形眼鏡鏡片中所佔之質量百分比為0.005%~1.5%。 In this embodiment, the contact lens may be a hydrogel lens or a hydrogel lens. When the contact lens is a hydrogel lens, the substrate is a hydrogel; when the contact lens is a hydrogel lens, the substrate is a hydrophobic gel. Wherein, the hydrogel and the hydrogel are formed by copolymerization of a hydrophilic monomer and a hydrated polymer under the action of a photoinitiator and a crosslinking agent. Wherein the hydrated polymer acts as a backbone of hydrogels and hydrogels, and the hydrophilic monomers act as functional monomers in hydrogels and hydrogels to increase their hydrophilicity and oxygen permeability. Sex and other performance. Further, the hydrophilic monomer and the hydrated polymer account for 94%-99.95% by mass of the contact lens. The percentage of the crosslinking agent in the contact lens is 0.001% to 2%. The mass percentage of the initiator in the contact lens is 0.005% to 1.5%.

更具體當該基體為水凝膠時，所述親水性單體可選自N-乙烯基吡咯烷酮(NVP)、甲基丙烯酸縮水甘油酯(GMA)以及N,N-二甲基丙烯醯胺(DMAA)中之其中一種，所述水合聚合物可包括甲基丙烯酸甲酯(MMA)以及甲基丙烯酸羥乙酯(HEMA)。當該基體為矽水凝膠時，所述親水性單體可為N-乙烯基吡咯烷酮(NVP)，所述水合聚合物可包括甲基丙烯酸甲酯(MMA)、甲基丙 烯酸羥乙酯(HEMA)、聚二甲基矽氧烷(PDMS)以及三羥甲基氨基甲烷(TRIS)。其中，所述光引發劑可採用Irgacure-1173(化工行業標準型號)，所述交聯劑可採用二甲基丙烯酸乙二醇酯(EGDMA)。 More specifically, when the substrate is a hydrogel, the hydrophilic monomer may be selected from the group consisting of N-vinylpyrrolidone (NVP), glycidyl methacrylate (GMA), and N,N-dimethyl decylamine ( One of DMAA), the hydrated polymer may include methyl methacrylate (MMA) and hydroxyethyl methacrylate (HEMA). When the substrate is a hydrophobic gel, the hydrophilic monomer may be N-vinylpyrrolidone (NVP), and the hydrated polymer may include methyl methacrylate (MMA), methyl propyl Hydroxyethyl enoate (HEMA), polydimethyl methoxy oxane (PDMS), and tris (hydroxymethyl) aminomethane (TRIS). Wherein, the photoinitiator may be Irgacure-1173 (chemical industry standard model), and the crosslinking agent may be ethylene glycol dimethacrylate (EGDMA).

於本實施方式中，本發明隱形眼鏡鏡片之生產制程可採用模子製作隱形眼鏡鏡片，包括注模或旋模。注模成型法適合作為短天期拋棄式鏡片或醫療使用。旋模成型法是將特殊配方之定量液態單體注入設定轉速之模內，液態單體因模子高速旋轉下離心力之作用形成凝膠，並經過脫模、水化等步驟得到隱形眼鏡鏡片。鏡片曲度由模具型狀、模子轉速控制，因其製造之鏡片抗韌度較佳，適合使用於長戴型或較長天期之拋棄式鏡片使用。 In the present embodiment, the production process of the contact lens of the present invention can use a mold to make a contact lens, including injection molding or a rotary mold. Injection molding is suitable for use as a short-day disposable lens or medical use. The rotary molding method is to inject a special formula of the quantitative liquid monomer into the mold of the set rotation speed, and the liquid monomer forms a gel by the centrifugal force of the mold rotating at a high speed, and obtains the contact lens by the steps of demoulding and hydration. The curvature of the lens is controlled by the shape of the mold and the rotational speed of the mold. The lens produced by the lens has better toughness and is suitable for use in a long-wearing type or a long-day disposable lens.

本發明還提供一種用於製備上述隱形眼鏡鏡片之隱形眼鏡鏡片材料，其包括由聚合物納米膠囊、親水性單體、水合聚合物、光引發劑以及交聯劑組成之混合物。其中，於紫外光照射下，所述親水性單體和水合聚合物可於光引發劑以及交聯劑之作用下發生共聚反應後形成基體，使該聚合物納米膠囊混合於該基體中。該聚合物納米膠囊包括過氧化氫溶液以及用以包裹該過氧化氫溶液之壁材。 The present invention also provides a contact lens material for use in the preparation of the above contact lens comprising a mixture of polymeric nanocapsules, a hydrophilic monomer, a hydrated polymer, a photoinitiator, and a crosslinking agent. Wherein, under the irradiation of ultraviolet light, the hydrophilic monomer and the hydrated polymer may form a matrix by copolymerization reaction under the action of a photoinitiator and a crosslinking agent, and the polymer nanocapsules are mixed in the matrix. The polymer nanocapsules include a hydrogen peroxide solution and a wall material for wrapping the hydrogen peroxide solution.

本發明項所述之隱形眼鏡鏡片中之聚合物納米膠囊中之過氧化氫能夠於光照等條件下分解成氧氣和水，以提高該隱形眼鏡鏡片之透氧性，並可以為角膜等部位提供必要之氧氣和水，防止角膜因缺氧而腫脹並對眼睛造成傷害。更進一步地，該過氧化氫還可以為該隱形眼鏡鏡片提供消毒功能，防止眼睛受到納米生物之感染。 The hydrogen peroxide in the polymer nanocapsules in the contact lens of the present invention can be decomposed into oxygen and water under the conditions of light and the like to improve the oxygen permeability of the contact lens, and can provide the cornea and the like. Necessary oxygen and water to prevent swelling of the cornea due to lack of oxygen and damage to the eyes. Further, the hydrogen peroxide can also provide a disinfecting function for the contact lens to prevent the eyes from being infected by the nano organism.

以上內容是結合具體之優選實施方式對本發明所作之進一步詳細說明，不能認定本發明之具體實施只局限於該等說明。對於本發明所屬技術領域之普通技術人員來說，於不脫離本發明構思之前提下做出複數等同替代或明顯變型，而且性能或用途相同，均應當視為屬於本發明由所提交之權利要求書確定之專利保護範圍。 The above is a further detailed description of the present invention in connection with the specific preferred embodiments, and the specific embodiments of the present invention are not limited to the description. For the person skilled in the art to which the invention pertains, a plurality of equivalent substitutes or obvious variants, and the same performance or use, should be considered as belonging to the present invention. The scope of patent protection determined by the book.

綜上所述，本發明係合乎發明專利申請條件，爰依法提出專利申請。惟，以上所述僅為本發明之較佳實施例，舉凡熟悉本案技藝之人士其所爰依本案之創作精神所作之等效修飾或變化，皆應涵蓋於以下之申請專利範圍內。 In summary, the present invention is in accordance with the conditions of the invention patent application, and the patent application is filed according to law. The above description is only the preferred embodiment of the present invention, and equivalent modifications or variations made by those skilled in the art to the spirit of the present invention should be included in the following claims.

Claims (10)

一種隱形眼鏡鏡片，包括基體，所述隱形眼鏡鏡片還包括混合於該基體中之聚合物納米膠囊，該聚合物納米膠囊能夠藉由化學反應釋放氧氣。 A contact lens comprising a substrate, the contact lens further comprising a polymer nanocapsule mixed in the matrix, the polymer nanocapsule capable of releasing oxygen by a chemical reaction. 如請求項第1項所述之隱形眼鏡鏡片，其中該聚合物納米膠囊包括過氧化氫溶液及包裹該過氧化氫溶液之壁材。 The contact lens of claim 1, wherein the polymer nanocapsule comprises a hydrogen peroxide solution and a wall material encasing the hydrogen peroxide solution. 如請求項第1項所述之隱形眼鏡鏡片，其中該聚合物納米膠囊於該隱形眼鏡鏡片中所佔之質量百分比為0.01%-5%。 The contact lens of claim 1, wherein the polymer nanocapsules comprise 0.01% to 5% by mass of the contact lens. 如請求項第3項所述之隱形眼鏡鏡片，其中該過氧化氫溶液於該聚合物納米膠囊中所佔之質量百分比為0.05%-10%，該過氧化氫溶液中過氧化氫之濃度為1%~35%(質量百分比)。 The contact lens according to claim 3, wherein the hydrogen peroxide solution accounts for 0.05%-10% by mass of the polymer nanocapsule, and the hydrogen peroxide concentration in the hydrogen peroxide solution is 1% to 35% (mass percentage). 如請求項第2項所述之隱形眼鏡鏡片，其中該壁材是可分解之高分子材料。 The contact lens of claim 2, wherein the wall material is a decomposable polymer material. 如請求項第5項所述之隱形眼鏡鏡片，其中該可分解之高分子材料包含甲殼素、聚乳酸羥基乙酸共聚物、海藻酸鈉、明膠或其他天然或合成之可分解性高分子。 The contact lens according to claim 5, wherein the decomposable polymer material comprises chitin, polylactic acid glycolic acid copolymer, sodium alginate, gelatin or other natural or synthetic decomposable polymer. 如請求項第1中項所述之隱形眼鏡鏡片，其中該基體為水凝膠，所述親水性單體選自N-乙烯基吡咯烷酮、甲基丙烯酸縮水甘油酯以及N,N-二甲基丙烯醯胺之其中一種，所述水合聚合物包括甲基丙烯酸甲酯以及甲基丙烯酸羥乙酯。 The contact lens of claim 1, wherein the substrate is a hydrogel, and the hydrophilic monomer is selected from the group consisting of N-vinylpyrrolidone, glycidyl methacrylate, and N,N-dimethyl One of acrylamide, the hydrated polymer comprising methyl methacrylate and hydroxyethyl methacrylate. 如請求項第1中項所述之隱形眼鏡鏡片，其中該基體為矽水凝膠，所述親水性單體為N-乙烯基吡咯烷酮，所述水合聚合物包括甲基丙烯酸甲酯、甲基丙烯酸羥乙酯、聚二甲基矽氧烷以及三羥甲基氨基甲烷。 The contact lens of claim 1, wherein the substrate is a hydrophobic gel, the hydrophilic monomer is N-vinylpyrrolidone, and the hydrated polymer comprises methyl methacrylate, methyl Hydroxyethyl acrylate, polydimethyl methoxy alkane, and trishydroxymethylaminomethane. 一種隱形眼鏡鏡片材料，用以製備隱形眼鏡鏡片，其中該隱形眼鏡鏡片材料包括由聚合物納米膠囊、親水性單體、水合聚合物、光引發劑以及交聯劑組成之混合物，於紫外光照射下，所述親水性單體和水合聚合物可於光引 發劑以及交聯劑之作用下發生共聚反應後形成基體，該聚合物納米膠囊混合於該基體中。 A contact lens material for preparing a contact lens, wherein the contact lens material comprises a mixture of polymer nanocapsules, a hydrophilic monomer, a hydrated polymer, a photoinitiator and a crosslinking agent, and is irradiated by ultraviolet light. The hydrophilic monomer and the hydrated polymer can be light-exposed The matrix is formed by the copolymerization reaction under the action of the hair agent and the crosslinking agent, and the polymer nanocapsules are mixed in the matrix. 如請求項第9項所述之隱形眼鏡鏡片材料，其中該聚合物納米膠囊包括過氧化氫溶液及包裹該過氧化氫溶液之壁材。 The contact lens material of claim 9, wherein the polymer nanocapsule comprises a hydrogen peroxide solution and a wall material encasing the hydrogen peroxide solution.
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CN1822867A (en) * 2003-07-16 2006-08-23 诺瓦提斯公司 Antimicrobial medical devices
US20110217355A1 (en) * 2007-09-04 2011-09-08 Anuj Chauhan Contact lens based bioactive agent delivery system
TW201543109A (en) * 2014-04-08 2015-11-16 Novartis Ag Ophthalmic lenses with oxygen-generating elements therein

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