TWI572390B - Magnetic micro - nano - material motion control device and its operation method - Google Patents
Magnetic micro - nano - material motion control device and its operation method Download PDFInfo
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本發明係關於一種控制裝置及其運作方法，尤指一種應用於控制磁性微奈米材料的運動，使磁性微奈米材料可在生物體內進行聚集、平移、旋轉、震動等活動而得作為傳遞藥物或清除血管內阻塞物等工具。 The invention relates to a control device and a method for operating the same, in particular to a motion for controlling a magnetic micro-nano material, so that the magnetic micro-nano material can be aggregated, translated, rotated, vibrated and the like in the living body to be transmitted. Tools such as drugs or removal of intravascular obstructions.
在各種奈米科技應用技術中，開發奈米生醫元件的重要性日趨益增，例如癌症早期診斷、藥物運送等許多項目均為主流之研究領域，而其中在生物相容性高的磁性奈米料操控技術上，目前則有進行協助腦中風診治及其他相關之應用。 Among various nanotechnology application technologies, the importance of developing nanomedicine components is increasing. Many projects such as early diagnosis of cancer and drug delivery are mainstream research fields, and among them, magnetic compatibility is high. In terms of rice material handling technology, there are currently assistance in the diagnosis and treatment of stroke and other related applications.
腦中風大致可以分為缺血性與出血性兩大類。其中的缺血性腦中風又稱為腦梗塞，主要是因為腦血管病變造成血管狹窄，導致血液無法輕易通過，而後形成血栓致使完全阻塞發生。對於缺血性腦中風或一般血栓而言，以傳統的藥物，例如抗凝血劑、血小板抑制劑等，其作用僅防止血栓繼續擴大，而無法將已阻塞的血栓溶解。雖然目前已有部分國家廣泛使用血栓溶劑而能夠有效地疏通血管來進行治療，但此類藥物可能對人體造成腦出血併發症，在治療時效上也有非常嚴格的限制。再者，此類藥物因為半衰期短，所以必須長期注射，在體內的最高藥效通常也僅有投藥量的75%，而注射至人體也容易受到血液中其他蛋白質的影響而失去 藥效。雖然目前有一些以基因改質的方式提升藥物活性及半衰期的技術，然而這些方式還是難以避免藥物在體內輸送的過程中流失。 Stroke can be roughly divided into two categories: ischemic and hemorrhagic. The ischemic stroke is also called cerebral infarction, mainly because the vascular stenosis caused by cerebral vascular disease, the blood can not easily pass, and then the formation of a thrombus caused complete obstruction. For ischemic stroke or general thrombosis, the traditional drugs, such as anticoagulants, platelet inhibitors, etc., only prevent the thrombus from expanding and cannot dissolve the blocked thrombus. Although some countries have widely used thrombus solvents to effectively clear blood vessels for treatment, such drugs may cause cerebral hemorrhage complications in humans, and there are very strict restrictions on treatment timeliness. In addition, because of the short half-life, these drugs must be injected for a long time. The highest efficacy in the body is usually only 75% of the dosage, and the injection into the human body is also easily affected by other proteins in the blood. Drug effect. Although there are some techniques for improving the activity and half-life of drugs by genetic modification, these methods are still difficult to avoid the loss of drugs in the process of delivery.
針對上述問題，目前已有技術使用磁性奈米粒子作為媒介，例如美國專利號US8715150，其係將磁性奈米粒子透過磁場控制，使其成為磁力棒，然後利用磁場使磁力棒旋轉，以使血栓逐漸剝離，剝離之碎屑與磁力棒集合成更大的磁性球體，並持續磨擦血栓，最終突破血栓。另外，此專利也有使磁性奈米粒子結合溶血栓藥物，讓溶血栓藥物能更有效地和血栓接觸。然而，此類技術目前的應用困難點在於控制磁性奈米粒子的設備過於龐大笨重，結構複雜而尚不能輕量化，因此在機動性、便利性以及成本等方面都仍待進一步改良。 In view of the above problems, the prior art uses magnetic nanoparticle as a medium, for example, US Pat. No. 8715150, which controls a magnetic nanoparticle through a magnetic field to make it a magnetic rod, and then uses a magnetic field to rotate the magnetic rod to make a thrombus. Gradually peeling off, the stripped debris and the magnetic rod gather into a larger magnetic sphere, and continue to rub the thrombus, eventually breaking through the thrombus. In addition, this patent also has magnetic nanoparticles combined with thrombolytic drugs to allow thrombolytic drugs to contact the thrombus more effectively. However, the current application difficulty of such technology lies in the fact that the equipment for controlling magnetic nano particles is too bulky and heavy, the structure is complicated, and the weight cannot be reduced, so that the mobility, convenience, and cost are still to be further improved.
本發明之主要目的，係提供一種磁性微奈米材料運動控制裝置，其可調控磁場以及方向，同時也可使磁場發生震盪，使磁性微奈米材料產生平移及旋轉運動。於此所指之磁性微奈米粒子可為具生物相容性且無毒性之四氧化三鐵，但不限於此，其粒子直徑約為數個奈米至數個微米。 The main object of the present invention is to provide a magnetic micro-nano material motion control device which can adjust a magnetic field and a direction, and can also oscillate a magnetic field to cause translational and rotational motion of the magnetic micro-nano material. The magnetic micro-nanoparticles referred to herein may be biocompatible and non-toxic triiron tetroxide, but are not limited thereto, and have a particle diameter of about several nanometers to several micrometers.
本發明之另一目的，係提供一種磁性微奈米材料運動控制裝置，其可控制磁性微奈米材料作動而幫助藥物於生物體中傳遞，或者是清除血管阻塞物等，廣泛應用於生醫領域。 Another object of the present invention is to provide a magnetic micro-nano material motion control device, which can control the movement of a magnetic micro-nano material to help a drug to be transferred in a living body, or to clear a blood vessel obstruction, etc., and is widely used in biomedicine. field.
本發明之再一目的，係提供一種磁性微奈米材料運動控制裝置，其結構簡化而可在尺寸實現手持之可能性，具有高機動性，並因 此可適用於人體之任何部位。 A further object of the present invention is to provide a magnetic micro-nano material motion control device, which has a simplified structure and can realize the possibility of being hand-held in size, has high mobility, and This can be applied to any part of the human body.
為了達到上述之目的，本發明揭示了一種磁性微奈米材料運動控制裝置及其運作方法，用於吸引一磁性微奈米材料，其在結構上包含了：一轉盤；一腔體，其係設置於該轉盤之上；至少一第一磁鐵以及至少一第二磁鐵，其設置於該於腔體之一內部頂面，形成一靜磁場；以及一第三磁鐵，其係設置於該腔體之一內部底面而位於該第一磁鐵以及該第二磁鐵之下，其一磁鐵頂面靠近該內部頂面，且該第三磁鐵係為電磁鐵。而於運作方法上，則包含了步驟：注入一磁性微奈米材料於一生物體內；使用該磁性微奈米材料運動控制裝置靠近該磁性微奈米材料注入於該生物體內之位置，使該磁性微奈米材料受到靜磁場影響，形成至少一磁力棒；啟動該磁性微奈米材料運動控制裝置之一第三磁鐵，其係為電磁鐵，使該磁力棒旋轉或震動；以及調整該磁力棒之轉速或方向，使該磁力棒與該生物體內之一血管阻塞物磨擦，因而使該血管阻塞物被分散。 In order to achieve the above object, the present invention discloses a magnetic micro-nano material motion control device and a method for operating the same, for attracting a magnetic micro-nano material, which comprises: a turntable; a cavity; Arranging on the turntable; at least one first magnet and at least one second magnet disposed on an inner top surface of the cavity to form a static magnetic field; and a third magnet disposed on the cavity One of the inner bottom surfaces is located below the first magnet and the second magnet, a magnet top surface is adjacent to the inner top surface, and the third magnet is an electromagnet. In the method of operation, the method comprises the steps of: injecting a magnetic micro-nano material into a living body; and using the magnetic micro-nano material motion control device to inject the magnetic micro-nano material into the living body, so that The magnetic micro-nano material is affected by the static magnetic field to form at least one magnetic rod; a third magnet of the magnetic micro-nano material motion control device is activated, which is an electromagnet to rotate or vibrate the magnetic rod; and adjust the magnetic force The rotational speed or direction of the rod causes the magnetic rod to rub against a blood vessel obstruction in the living body, thereby causing the blood vessel obstruction to be dispersed.
1‧‧‧腔體 1‧‧‧ cavity
10‧‧‧內部底面 10‧‧‧ Interior bottom
11‧‧‧內部頂面 11‧‧‧ Interior top surface
12‧‧‧支柱 12‧‧‧ pillar
2‧‧‧轉盤 2‧‧‧ Turntable
31‧‧‧第一磁鐵 31‧‧‧First magnet
310‧‧‧第一板體 310‧‧‧First board
32‧‧‧第二磁鐵 32‧‧‧Second magnet
320‧‧‧第二板體 320‧‧‧Second plate
33‧‧‧第三磁鐵 33‧‧‧ Third magnet
330‧‧‧磁鐵頂面 330‧‧‧Magnet top
331‧‧‧升降模組 331‧‧‧ Lifting module
4‧‧‧磁力棒 4‧‧‧Magnetic rod
S1~S4‧‧‧步驟 S1~S4‧‧‧ steps
第1圖：其係為本發明一較佳實施例之結構分解示意圖；第2圖：其係為本發明另一較佳實施例之側視結構示意圖；第3圖：其係為本發明又一較佳實施例之部分結構示意圖，用以表示第一磁鐵以及第二磁鐵係分別固定於第一板體以及第二板體而以陣列方式排列，但本發明並不限制於使用陣列排列的形式，只要異性相吸形成一靜磁場皆包含之；第4圖：其係為本發明一較佳實施例之部分結構示意圖，用以表示靜磁場方向； 第5A圖：其係為本發明一較佳實施例中，磁力棒受磁場變化而旋轉之示意圖；第5B圖：其係為本發明一較佳實施例中，磁力棒受磁場變化而震動之示意圖；以及第6圖：其係為本發明一較佳實施例之運作方法步驟流程圖。 1 is a schematic exploded view of a preferred embodiment of the present invention; FIG. 2 is a schematic side view of another preferred embodiment of the present invention; FIG. 3 is a view of the present invention A partial structural view of a preferred embodiment for indicating that the first magnet and the second magnet are respectively fixed to the first plate and the second plate and arranged in an array, but the present invention is not limited to the use of the array arrangement. The form is included as long as the opposite sex attracts a static magnetic field; FIG. 4 is a partial structural diagram of a preferred embodiment of the present invention for indicating the direction of the static magnetic field; FIG. 5A is a schematic view showing a magnetic bar being rotated by a magnetic field according to a preferred embodiment of the present invention; FIG. 5B is a view showing a magnetic bar being vibrated by a magnetic field change according to a preferred embodiment of the present invention; Schematic diagram; and Figure 6 is a flow chart showing the steps of the operation method of a preferred embodiment of the present invention.
為使本發明之特徵及所達成之功效有更進一步之瞭解與認識，謹佐以較佳之實施例及配合詳細之說明，說明如後：請參考第1圖，在本發明之一較佳實施例中，其結構係包含一腔體1、一轉盤2、至少一第一磁鐵31、至少一第二磁鐵32以及一第三磁鐵33。其中，腔體1係設置於轉盤2之上；第一磁鐵31以及第二磁鐵32係設置於腔體1之內部頂面11；第三磁鐵33則係設置於腔體1之內部底面10而位於第一磁鐵31以及第二磁鐵32之下。 For a better understanding and understanding of the features and advantages of the present invention, the preferred embodiments and the detailed description are as follows: Referring to Figure 1, a preferred embodiment of the present invention In the example, the structure includes a cavity 1, a turntable 2, at least one first magnet 31, at least one second magnet 32, and a third magnet 33. The cavity 1 is disposed on the turntable 2; the first magnet 31 and the second magnet 32 are disposed on the inner top surface 11 of the cavity 1; and the third magnet 33 is disposed on the inner bottom surface 10 of the cavity 1 Located below the first magnet 31 and the second magnet 32.
本發明在此較佳實施例中的腔體1僅係用於支撐與承載其他元件，內部底面10以及內部頂面11可透過複數個支柱12作連接而在腔體1之內撐起足夠的空間讓第三磁鐵33位於第一磁鐵31以及第二磁鐵32之下方，且其一磁鐵頂部330貼近於內部頂面11。本發明並不限制於使用支柱的形式，也可將各個元件密封於封閉的完整腔體之內。 The cavity 1 of the preferred embodiment of the present invention is only used to support and carry other components. The inner bottom surface 10 and the inner top surface 11 can be connected through the plurality of pillars 12 to support the cavity 1 sufficiently. The space allows the third magnet 33 to be positioned below the first magnet 31 and the second magnet 32, and a magnet top 330 is adjacent to the inner top surface 11. The invention is not limited to the use of struts, but the individual components can also be sealed within a closed, complete cavity.
本發明於此較佳實施例所使用之轉盤2係為電控轉盤，其可透過電控的方式旋轉整個腔體1，而其附屬之電路及控制單元則整合於其下方。腔體1之內部頂面11設置有第一磁鐵31以及第二磁鐵32，此第一磁鐵31以及第二磁鐵32可為單一之磁塊而直接黏合於 腔體1內部頂面11，或者是如第3圖所示，係分別透過第一板體310以及第二板體320而設置於腔體1之內部頂面11。第一磁鐵31以及第二磁鐵32可為長條狀的永久磁鐵，以形狀相同者為佳，兩者平行排列而使均勻的靜磁場分布於腔體1的上方區域，但本發明並不限制於使用長條狀的形式，也不限制於平行排列第一磁鐵31以及第二磁鐵32，只要是透過異性相吸而形成一靜磁場皆可。第一磁鐵31以及第二磁鐵32之排列以異性相吸為較佳，避免同性相斥之排列而造成第一磁鐵31以及第二磁鐵32的磁性經長期使用後有所耗損；再者，以異性相吸之排列也有助於磁力棒的形成，此部分於後段補述。 The turntable 2 used in the preferred embodiment of the present invention is an electronically controlled turntable that can electrically rotate the entire cavity 1 while its associated circuit and control unit are integrated underneath. The inner top surface 11 of the cavity 1 is provided with a first magnet 31 and a second magnet 32. The first magnet 31 and the second magnet 32 can be directly bonded to a single magnetic block. The inner top surface 11 of the cavity 1 or, as shown in FIG. 3, is disposed on the inner top surface 11 of the cavity 1 through the first plate body 310 and the second plate body 320, respectively. The first magnet 31 and the second magnet 32 may be elongated permanent magnets, preferably in the same shape, and arranged in parallel so that a uniform static magnetic field is distributed in the upper region of the cavity 1, but the invention is not limited thereto. In the case of using a strip shape, it is not limited to the parallel arrangement of the first magnet 31 and the second magnet 32, as long as a static magnetic field is formed by attracting the opposite sex. It is preferable that the arrangement of the first magnet 31 and the second magnet 32 are oppositely attracted, and the magnetic properties of the first magnet 31 and the second magnet 32 are depleted after long-term use by avoiding the arrangement of the same polarity repelling; The arrangement of the opposite sex attracts also contributes to the formation of the magnetic rod, which is supplemented in the latter paragraph.
第一磁鐵31以及第二磁鐵32之功能係在於利用磁力聚集磁性微奈米材料。磁性微奈米粒子可為具生物相容性且無毒性之四氧化三鐵，但不限於此，其粒子直徑則約為數個奈米至數個微米。本發明在應用之前，這些磁性微奈米材料係以溶液為載體而預先注入生物體內，因此將本發明靠近這些磁性微奈米材料溶液注入生物體內之位置附近，例如貼於皮膚表面，使得位於生物體內之磁性微奈米材料受到生物體外的第一磁鐵31以及第二磁鐵32所提供的靜磁場影響，得以聚集而形成磁力棒4，如第4圖所示。 The function of the first magnet 31 and the second magnet 32 is to concentrate the magnetic micro-nano material by magnetic force. The magnetic micro-nanoparticles may be biocompatible and non-toxic triiron tetroxide, but are not limited thereto, and have a particle diameter of about several nanometers to several micrometers. Before the application of the present invention, the magnetic micro-nano materials are pre-injected into the living body by using the solution as a carrier, so that the present invention is injected near the position of the magnetic micro-nano material solution into the living body, for example, attached to the skin surface, so that the The magnetic micro-nano material in the living body is affected by the static magnetic field supplied from the first magnet 31 and the second magnet 32 outside the living body, and is aggregated to form the magnetic rod 4 as shown in Fig. 4.
待磁力棒4形成，接著就可使用第三磁鐵33讓磁力棒4開始旋轉。第三磁鐵33係為一電磁鐵，經開啟而導入交流電後，由於交流電之電流方向會不斷變化，因此第三磁鐵33的磁場方向也會不斷變化，導致磁力棒4產生旋轉(如第5A圖所示)或是在一定範圍內發生高速震動(如第5B圖所示)。這些受第三磁鐵33之磁場變化而具轉動/震動能力之磁力棒4得以在生物體內進行清除血栓、血脂等 血管阻塞物之工作，也就是透過血栓物質與磁力棒4之間的磨擦，使得阻塞血管之血栓、血脂得以被分散為小塊，進而被突破、清除，達到消除血管阻塞物的目的。 After the magnetic rod 4 is formed, the third magnet 33 can be used to start the rotation of the magnetic rod 4. The third magnet 33 is an electromagnet. After the alternating current is introduced and the alternating current is introduced, the direction of the magnetic field of the third magnet 33 is constantly changed, so that the magnetic rod 4 is rotated (for example, FIG. 5A). As shown) or high-speed vibration within a certain range (as shown in Figure 5B). These magnetic rods 4, which are rotated/vibrated by the magnetic field of the third magnet 33, are capable of removing blood clots, blood lipids, etc. in the living body. The work of vascular obstruction, that is, the friction between the thrombus substance and the magnetic rod 4, causes the thrombus and blood lipids of the blocked blood vessel to be dispersed into small pieces, which are then broken and cleared to achieve the purpose of eliminating the vascular obstruction.
基於上述的結構與機制，本發明在消除血栓的操作調控上，可利用：(A)改變輸入之交流電的強度而調整磁力棒4的旋轉轉速或震動速率；(B)第三磁鐵33與腔體1之接觸之面之間可進一步設置一升降模組331(如第2圖所示)，使磁力棒4得以隨著第三磁鐵33的垂直升降而有相對應的垂直移動，而若是在生物體外直接移動本發明，也可獲得類似的效果；或是(C)轉盤2的轉動則可改變第一磁鐵31以及第二磁鐵32所提供給磁性微奈米材料的靜磁場方向，使磁力棒4的旋轉軸受到改變，因而能以不同的角度對血管阻塞物進行磨擦，提高清除血管阻塞物的效率。 Based on the above structure and mechanism, the present invention can utilize: (A) changing the intensity of the input alternating current to adjust the rotational speed or vibration rate of the magnetic rod 4; (B) the third magnet 33 and the cavity A lifting module 331 (shown in FIG. 2) may be further disposed between the contact faces of the body 1, so that the magnetic bar 4 has a corresponding vertical movement with the vertical lifting of the third magnet 33, and if A similar effect can be obtained by directly moving the invention in vitro; or (C) the rotation of the turntable 2 can change the direction of the static magnetic field provided by the first magnet 31 and the second magnet 32 to the magnetic micro-nano material, so that the magnetic force The axis of rotation of the rod 4 is altered so that the blood vessel obstruction can be rubbed at different angles, improving the efficiency of clearing the blood vessel obstruction.
本發明在應用於清除血管阻塞物的整體方法中，可整理為以下步驟：步驟S1：注入一磁性微奈米材料於一生物體內；步驟S2：使用本發明之磁性微奈米材料運動控制裝置靠近該磁性微奈米材料注入於該生物體內之位置，使該磁性微奈米材料受到靜磁場影響，形成至少一磁力棒；步驟S3：啟動該磁性微奈米材料運動控制裝置之一第三磁鐵，其係為電磁鐵，使該磁力棒旋轉或震動；以及步驟S4：調整該磁力棒之轉速或方向，使該磁力棒與該生物體內之一血管阻塞物磨擦，因而使該血管阻塞物被分散。 In the overall method for removing vascular obstructions, the present invention can be organized into the following steps: Step S1: injecting a magnetic micro-nano material into a living body; Step S2: using the magnetic micro-nano material motion control device of the present invention Adjacent to the magnetic micro-nano material injected into the living body, the magnetic micro-nano material is affected by the static magnetic field to form at least one magnetic rod; step S3: starting one of the magnetic micro-nano material motion control devices a magnet, which is an electromagnet, causes the magnetic rod to rotate or vibrate; and step S4: adjusting the rotation speed or direction of the magnetic rod to cause the magnetic rod to rub against a blood vessel obstruction in the living body, thereby causing the blood vessel obstruction Being dispersed.
綜上所述，本發明詳細揭示了一種磁性微奈米材料運動控制裝置，其係可有效地由生物體之外部進行磁控，除了可將磁性微奈米 材料引導至生物體內之特定位置進行應用，更可操控該些磁性微奈米材料作為在生物體內進行旋轉或是震動等各式運動行為之元件，因此使磁性微奈米材料被有效地運用於生物醫學領域。再者，本發明之結構較此技術領域之現有設計更為簡化，機動性較高，可以手持方式為之，亦可適用於人體的任何部位。基於上述多種優點，本發明確實為一種兼具實用與經濟價值之磁性微奈米材料運動控制裝置。 In summary, the present invention discloses in detail a magnetic micro-nano material motion control device, which can effectively perform magnetic control from the outside of the living body, except that the magnetic micro-nano can be used. The material is guided to a specific position in the living body for application, and the magnetic micro-nano material can be manipulated as a component for performing various kinds of motion behaviors such as rotation or vibration in the living body, thereby effectively applying the magnetic micro-nano material. The field of biomedicine. Furthermore, the structure of the present invention is more simplified than the prior art in the technical field, and has high mobility, can be held by hand, and can be applied to any part of the human body. Based on the above various advantages, the present invention is indeed a magnetic micro-nano material motion control device having both practical and economical value.
惟以上所述者，僅為本發明之較佳實施例而已，並非用來限定本發明實施之範圍，舉凡依本發明申請專利範圍所述之形狀、構造、特徵及精神所為之均等變化與修飾，均應包括於本發明之申請專利範圍內。 The above is only the preferred embodiment of the present invention, and is not intended to limit the scope of the present invention, and the variations, modifications, and modifications of the shapes, structures, features, and spirits described in the claims of the present invention. All should be included in the scope of the patent application of the present invention.
1‧‧‧腔體 1‧‧‧ cavity
10‧‧‧內部底面 10‧‧‧ Interior bottom
11‧‧‧內部頂面 11‧‧‧ Interior top surface
12‧‧‧支柱 12‧‧‧ pillar
2‧‧‧轉盤 2‧‧‧ Turntable
31‧‧‧第一磁鐵 31‧‧‧First magnet
32‧‧‧第二磁鐵 32‧‧‧Second magnet
33‧‧‧第三磁鐵 33‧‧‧ Third magnet
330‧‧‧磁鐵頂面 330‧‧‧Magnet top
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| CN1101585A (en) * | 1993-10-08 | 1995-04-19 | 张小云 | Low frequency rotation permanent magnetic field therapeutic device |
| US20110071335A1 (en) * | 2009-09-22 | 2011-03-24 | Empire Technology Development Llc | Applications of alternating magnetic fields on magnetic nanoparticles |
| CN102814004A (en) * | 2012-09-07 | 2012-12-12 | 北京大学 | Gyromagnet treatment system based on magnetic nanoparticles |
| US20140135564A1 (en) * | 2009-11-02 | 2014-05-15 | Pulse Therapeutics, Inc. | Controlling magnetic nanoparticles to increase vascular flow |
| WO2014140282A1 (en) * | 2013-03-15 | 2014-09-18 | Milux Holding S.A. | Operable implant comprising an electrical motor and a gear system |
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|---|---|---|---|---|
| CN1101585A (en) * | 1993-10-08 | 1995-04-19 | 张小云 | Low frequency rotation permanent magnetic field therapeutic device |
| US20110071335A1 (en) * | 2009-09-22 | 2011-03-24 | Empire Technology Development Llc | Applications of alternating magnetic fields on magnetic nanoparticles |
| US20140135564A1 (en) * | 2009-11-02 | 2014-05-15 | Pulse Therapeutics, Inc. | Controlling magnetic nanoparticles to increase vascular flow |
| CN102814004A (en) * | 2012-09-07 | 2012-12-12 | 北京大学 | Gyromagnet treatment system based on magnetic nanoparticles |
| WO2014140282A1 (en) * | 2013-03-15 | 2014-09-18 | Milux Holding S.A. | Operable implant comprising an electrical motor and a gear system |
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