TWI561522B - Substituted imidazopyridinyl-aminopyridine compounds - Google Patents
Substituted imidazopyridinyl-aminopyridine compoundsInfo
- Publication number
- TWI561522B TWI561522B TW101122473A TW101122473A TWI561522B TW I561522 B TWI561522 B TW I561522B TW 101122473 A TW101122473 A TW 101122473A TW 101122473 A TW101122473 A TW 101122473A TW I561522 B TWI561522 B TW I561522B
- Authority
- TW
- Taiwan
- Prior art keywords
- substituted imidazopyridinyl
- aminopyridine compounds
- aminopyridine
- compounds
- imidazopyridinyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161500889P | 2011-06-24 | 2011-06-24 |
Publications (2)
Publication Number | Publication Date |
---|---|
TW201311687A TW201311687A (zh) | 2013-03-16 |
TWI561522B true TWI561522B (en) | 2016-12-11 |
Family
ID=47362419
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TW101122473A TWI561522B (en) | 2011-06-24 | 2012-06-22 | Substituted imidazopyridinyl-aminopyridine compounds |
Country Status (17)
Country | Link |
---|---|
US (2) | US8609688B2 (zh) |
EP (1) | EP2723741B8 (zh) |
JP (1) | JP6046710B2 (zh) |
KR (2) | KR101974673B1 (zh) |
CN (1) | CN103748093B (zh) |
AU (2) | AU2012272937B2 (zh) |
BR (1) | BR112013033182A2 (zh) |
CA (1) | CA2837727C (zh) |
DK (1) | DK2723741T3 (zh) |
ES (1) | ES2579855T3 (zh) |
HK (1) | HK1196371A1 (zh) |
IL (3) | IL229719A0 (zh) |
MX (1) | MX339862B (zh) |
PH (1) | PH12013502565B1 (zh) |
TW (1) | TWI561522B (zh) |
WO (1) | WO2012177844A2 (zh) |
ZA (1) | ZA201308929B (zh) |
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ATE534415T1 (de) | 2005-12-13 | 2011-12-15 | Harvard College | Gerüste zur zelltransplantation |
WO2009002401A2 (en) | 2007-06-21 | 2008-12-31 | President And Fellows Of Harvard College | Scaffolds for cell collection or elimination |
JP5690143B2 (ja) | 2008-02-13 | 2015-03-25 | プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ | 持続的細胞プログラミング装置 |
US9370558B2 (en) | 2008-02-13 | 2016-06-21 | President And Fellows Of Harvard College | Controlled delivery of TLR agonists in structural polymeric devices |
US9012399B2 (en) * | 2008-05-30 | 2015-04-21 | President And Fellows Of Harvard College | Controlled release of growth factors and signaling molecules for promoting angiogenesis |
WO2010120749A2 (en) | 2009-04-13 | 2010-10-21 | President And Fellow Of Harvard College | Harnessing cell dynamics to engineer materials |
EP2461828B1 (en) | 2009-07-31 | 2017-06-21 | President and Fellows of Harvard College | Programming of cells for tolerogenic therapies |
WO2011103289A2 (en) * | 2010-02-17 | 2011-08-25 | Jasco Pharmaceuticals, LLC | Imidazole-2, 4-dione inhibitors of casein kinase 1 |
EP2585053A4 (en) | 2010-06-25 | 2014-02-26 | Harvard College | COMMON RELEASE OF STIMULATING AND HEMMING FACTORS FOR THE PRODUCTION OF TEMPORARY STABILIZED AND SPATULARLY LIMITED ZONES |
KR102155383B1 (ko) | 2010-10-06 | 2020-09-11 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 재료에 기초한 세포 치료를 위한 주사 가능한 기공 형성 하이드로겔 |
US9603894B2 (en) | 2010-11-08 | 2017-03-28 | President And Fellows Of Harvard College | Materials presenting notch signaling molecules to control cell behavior |
US10647959B2 (en) | 2011-04-27 | 2020-05-12 | President And Fellows Of Harvard College | Cell-friendly inverse opal hydrogels for cell encapsulation, drug and protein delivery, and functional nanoparticle encapsulation |
ES2685327T3 (es) | 2011-04-28 | 2018-10-08 | President And Fellows Of Harvard College | Armazones tridimensionales macroscópicos preformados inyectables para administración mínimamente invasiva |
US9675561B2 (en) | 2011-04-28 | 2017-06-13 | President And Fellows Of Harvard College | Injectable cryogel vaccine devices and methods of use thereof |
US9486512B2 (en) | 2011-06-03 | 2016-11-08 | President And Fellows Of Harvard College | In situ antigen-generating cancer vaccine |
BR112013033182A2 (pt) * | 2011-06-24 | 2016-09-06 | Arqule Inc | compostos imidazopiridinil-aminopiridina substituída |
US9937249B2 (en) | 2012-04-16 | 2018-04-10 | President And Fellows Of Harvard College | Mesoporous silica compositions for modulating immune responses |
KR20160099081A (ko) | 2013-07-26 | 2016-08-19 | 업데이트 파마 인코포레이트 | 비산트렌의 치료 효과 개선용 조합 방법 |
AU2015236273B2 (en) * | 2014-03-24 | 2019-03-28 | Arqule Inc. | Process of preparing 3-(3-(4-(1-aminocyclobutyl)phenyl)-5-phenyl-3H-imidazo(4,5-b)pyridin-2-yl)pyridin-2-amine |
CN106659765B (zh) | 2014-04-04 | 2021-08-13 | 德玛医药 | 二脱水半乳糖醇及其类似物或衍生物用于治疗非小细胞肺癌和卵巢癌的用途 |
BR112016024521A2 (pt) * | 2014-04-22 | 2017-08-15 | Arqule Inc | sais e polimorfos de um composto imidazopiridinil-aminopiridina |
CN107073090A (zh) | 2014-04-30 | 2017-08-18 | 哈佛学院董事会 | 结合的疫苗装置和杀死癌细胞的方法 |
EP3189036B1 (en) | 2014-09-05 | 2023-07-19 | ArQule, Inc. | Compositions and methods for treating proliferation disorders |
WO2016123573A1 (en) | 2015-01-30 | 2016-08-04 | President And Fellows Of Harvard College | Peritumoral and intratumoral materials for cancer therapy |
US11150242B2 (en) | 2015-04-10 | 2021-10-19 | President And Fellows Of Harvard College | Immune cell trapping devices and methods for making and using the same |
CN105315161B (zh) * | 2015-06-05 | 2017-08-04 | 厦门医学院 | 一类PKB/Akt抑制剂的关键中间体的制备方法 |
CN115531609A (zh) | 2016-02-06 | 2022-12-30 | 哈佛学院校长同事会 | 重塑造血巢以重建免疫 |
WO2018013430A2 (en) | 2016-07-12 | 2018-01-18 | Arisan Therapeutics Inc. | Heterocyclic compounds for the treatment of arenavirus infection |
MA45738A (fr) | 2016-07-13 | 2019-05-22 | Harvard College | Échafaudages mimétiques de cellules présentant l'antigène et procédés pour les préparer et les utiliser |
CA3118493A1 (en) | 2018-11-05 | 2020-05-14 | Iovance Biotherapeutics, Inc. | Expansion of tils utilizing akt pathway inhibitors |
CA3193341A1 (en) * | 2020-09-30 | 2022-04-07 | Yinsheng ZHANG | Compound as akt kinase inhibitor |
CN117769554A (zh) | 2021-05-28 | 2024-03-26 | 大鹏药品工业株式会社 | Kras突变蛋白的小分子抑制剂 |
WO2024039884A1 (en) * | 2022-08-19 | 2024-02-22 | Atomic Ai, Inc. | Methods, systems, and media method applying machine learning to chemical mapping data for rna tertiary structure prediction |
Citations (2)
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US20060035921A1 (en) * | 2003-08-21 | 2006-02-16 | Castelhano Arlindo L | N3-substituted imidazopyridine c-Kit inhibitors |
WO2011082270A2 (en) * | 2009-12-30 | 2011-07-07 | Arqule. Inc. | Substituted imidazopyridinyl-aminopyridine compounds |
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AR045134A1 (es) | 2003-07-29 | 2005-10-19 | Smithkline Beecham Plc | Compuesto de 1h - imidazo [4,5-c] piridin-ilo, composicion farmaceutica que lo comprende, proceso para prepararla, su uso para preparar dicha composicion farmaceutica, combinacion farmaceutica, uso de la combinacion farmaceutica para la preparacion de un medicamento, procedimientos para preparar dic |
ATE425977T1 (de) * | 2003-08-21 | 2009-04-15 | Osi Pharm Inc | 3-substituierte imidazopyridinderivate als c-kit- inhibitoren |
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PL2054405T3 (pl) | 2006-07-11 | 2014-03-31 | Dae Woong Pharma | Nowe pochodne biarylobenzimidazolu i zawierająca je kompozycja farmaceutyczna |
AR064010A1 (es) * | 2006-12-06 | 2009-03-04 | Merck & Co Inc | Inhibidores de la actividad de la akt |
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KR20090007347U (ko) | 2008-01-16 | 2009-07-21 | 춘-치 왕 | 가속 페달 포지션 센서를 구비한 자동차용 연료 공급 기구 |
BR112013033182A2 (pt) * | 2011-06-24 | 2016-09-06 | Arqule Inc | compostos imidazopiridinil-aminopiridina substituída |
US8815854B2 (en) | 2011-06-24 | 2014-08-26 | Arqule, Inc. | Substituted imidazopyridinyl compounds |
-
2012
- 2012-06-21 BR BR112013033182A patent/BR112013033182A2/pt not_active Application Discontinuation
- 2012-06-21 MX MX2013015006A patent/MX339862B/es active IP Right Grant
- 2012-06-21 ES ES12802947.7T patent/ES2579855T3/es active Active
- 2012-06-21 WO PCT/US2012/043501 patent/WO2012177844A2/en active Application Filing
- 2012-06-21 KR KR1020137034886A patent/KR101974673B1/ko active IP Right Grant
- 2012-06-21 JP JP2014517149A patent/JP6046710B2/ja active Active
- 2012-06-21 US US13/529,459 patent/US8609688B2/en active Active
- 2012-06-21 EP EP12802947.7A patent/EP2723741B8/en active Active
- 2012-06-21 CA CA2837727A patent/CA2837727C/en active Active
- 2012-06-21 KR KR1020197003119A patent/KR20190015600A/ko not_active Application Discontinuation
- 2012-06-21 AU AU2012272937A patent/AU2012272937B2/en active Active
- 2012-06-21 DK DK12802947.7T patent/DK2723741T3/en active
- 2012-06-21 CN CN201280030830.8A patent/CN103748093B/zh active Active
- 2012-06-22 TW TW101122473A patent/TWI561522B/zh active
-
2013
- 2013-11-08 US US14/075,505 patent/US8962619B2/en active Active
- 2013-11-27 ZA ZA2013/08929A patent/ZA201308929B/en unknown
- 2013-11-28 IL IL229719A patent/IL229719A0/en active IP Right Grant
- 2013-12-10 PH PH12013502565A patent/PH12013502565B1/en unknown
-
2014
- 2014-10-06 HK HK14109924.6A patent/HK1196371A1/zh unknown
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2016
- 2016-12-05 AU AU2016269408A patent/AU2016269408B2/en active Active
-
2019
- 2019-04-08 IL IL265897A patent/IL265897B/en unknown
-
2021
- 2021-09-05 IL IL286152A patent/IL286152A/en unknown
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060035921A1 (en) * | 2003-08-21 | 2006-02-16 | Castelhano Arlindo L | N3-substituted imidazopyridine c-Kit inhibitors |
WO2011082270A2 (en) * | 2009-12-30 | 2011-07-07 | Arqule. Inc. | Substituted imidazopyridinyl-aminopyridine compounds |
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