TWI401054B - Capsule endoscope and method for manufacturing lens thereof - Google Patents
Capsule endoscope and method for manufacturing lens thereof Download PDFInfo
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- TWI401054B TWI401054B TW97140857A TW97140857A TWI401054B TW I401054 B TWI401054 B TW I401054B TW 97140857 A TW97140857 A TW 97140857A TW 97140857 A TW97140857 A TW 97140857A TW I401054 B TWI401054 B TW I401054B
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Description
本發明涉及一種醫療檢查器具，特別涉及一種膠囊內視鏡及其鏡片之製造方法。The invention relates to a medical examination instrument, in particular to a capsule endoscope and a method of manufacturing the same.
早在1795年，就有許多醫學先輩開始進行消化道之檢查。在檢查儀器較粗糙不便之情況下，通常只能針對消化道之前後端作檢查，而後為了改善檢查之便利性，出現了內視鏡之構想及發明。檢查時，將管子***所要檢查之器官內，從管子之***端之冷光源所發出來之冷光將器官內部照亮，然後由管子***端所鑲嵌之影像感測晶片拍攝之影像信號經管子傳送回電腦，由電腦將信號轉換成影像，在檢查消化道時，仍然有一大段小腸不容易用內視鏡檢查，因為傳統式之內視鏡如果長度太長，操控將比較困難，病人也就要承受比較大之痛苦。As early as 1795, many medical ancestors began to examine the digestive tract. In the case where the inspection instrument is rough and inconvenient, it is usually only possible to check the front end of the digestive tract, and then in order to improve the convenience of inspection, the concept and invention of the endoscope have emerged. During the inspection, the tube is inserted into the organ to be inspected, and the cold light from the cold light source at the insertion end of the tube illuminates the inside of the organ, and then the image signal taken by the image sensing wafer embedded in the insertion end of the tube is transmitted through the tube. Back to the computer, the computer converts the signal into an image. When examining the digestive tract, there is still a large segment of the small intestine that is not easy to check with an endoscope. Because the traditional endoscope is too long, the manipulation will be more difficult, and the patient will be To bear more pain.
隨著科技之進步，逐漸發展出利用生物無線遙測之技術，捨棄先前有線傳輸，再從體積和使用方式上解決目前內視鏡之缺點。近年更誕生了許多如膠囊藥物一般大小之膠囊內視鏡。然而，就臨床應用上，仍有部分患者因為腸道狹窄而使膠囊內視鏡阻塞在腸道內無法正常排出體外，而此時只能開刀從體內取出，這無疑增加了患者之痛苦。With the advancement of technology, the technology of using bio-wireless telemetry has been gradually developed, the previous wired transmission has been abandoned, and the shortcomings of current endoscopes have been solved in terms of volume and usage. In recent years, many capsule endoscopes, such as capsule drugs, have been born. However, in clinical applications, some patients still have capsule endoscopes that cannot be properly excreted in the intestine due to intestinal stenosis. At this time, they can only be removed from the body, which undoubtedly increases the suffering of the patients.
有鑒於此，有必要提供一種體積較小之膠囊內視鏡及其鏡片之製造方法。In view of the above, it is necessary to provide a capsule inner mirror and a method of manufacturing the same.
一種膠囊內視鏡，其包括一膠囊殼體、一鏡頭模組、至少一光源、一影像感測晶片、一記憶體、至少一電源、一無線發射模組及一收容腔體。所述鏡頭模組包括一鏡座及固定在所述鏡座上之至少一鏡片。所述膠囊殼體及所述鏡頭模組均由生物可降解材料製成。所述收容腔體用透明且表面光滑之薄膜製成，所述薄膜為不可降解材料製成，所述光源、影像感測晶片、記憶體、電源及無線發射模組均收容於所述收容腔體內。所述電源用於給所述光源、影像感測晶片、記憶體及無線發射模組提供電力。所述光源用於發射光線至所述膠囊殼體外。所述記憶體用於存儲所述影像感測晶片形成之影像資訊。所述無線發射模組用於無線發射所述記憶體中之影像資訊。A capsule endoscope includes a capsule housing, a lens module, at least one light source, an image sensing chip, a memory, at least one power source, a wireless transmitting module, and a receiving cavity. The lens module includes a lens holder and at least one lens fixed to the lens holder. The capsule housing and the lens module are both made of a biodegradable material. The receiving cavity is made of a transparent and smooth surface film, the film is made of a non-degradable material, and the light source, the image sensing chip, the memory, the power source and the wireless transmitting module are all accommodated in the receiving cavity. in vivo. The power source is used to provide power to the light source, the image sensing chip, the memory, and the wireless transmitting module. The light source is for emitting light outside of the capsule housing. The memory is used to store image information formed by the image sensing wafer. The wireless transmitting module is configured to wirelessly transmit image information in the memory.
一種上述之膠囊內視鏡之鏡片之製造方法，包括以下步驟：提供一第一基板；在所述第一基板上進行加工，形成複數突起之微鏡結構；在第一溫度下用塗層材料塗布在所述第一基板上，經過第一時間段硬化形成與所述微鏡結構對應之具有複數凹陷之微結構之第二基板；將所述第二基板從所述第一基板上分離；在第二溫度下在所述第二基板上塗布生物可降解材料，經過第二時間段硬化形成由生物可降解材料製成之具有複數微鏡結構之第三基板；及 將所述第三基板上之複數微鏡結構經過切割得到複數鏡片。A method for manufacturing a lens of the capsule endoscope, comprising the steps of: providing a first substrate; processing on the first substrate to form a plurality of protrusions of a micromirror structure; and coating materials at a first temperature Coating on the first substrate, hardening through a first period of time to form a second substrate having a plurality of recessed microstructures corresponding to the micromirror structure; separating the second substrate from the first substrate; Coating a biodegradable material on the second substrate at a second temperature, and hardening over a second period of time to form a third substrate having a plurality of micromirror structures made of a biodegradable material; The plurality of micromirror structures on the third substrate are cut to obtain a plurality of lenses.
與先前技術相比，上述膠囊內視鏡，因為所述膠囊殼體及鏡頭模組均由生物可降解材料製成，故可以在生物體內降解，所以整個膠囊內視鏡之體積減小，更容易排出體外。Compared with the prior art, the capsule endoscope has a capsule body and a lens module which are made of a biodegradable material and can be degraded in the living body, so that the volume of the entire capsule endoscope is reduced, and Easy to excrete.
上述鏡片製造方法，使製造上述膠囊內視鏡之鏡片之制程簡單。The lens manufacturing method described above makes the process of manufacturing the lens of the capsule endoscope simple.
為了對本發明之膠囊內視鏡及其鏡片之製造方法做進一步之說明，舉以下實施方式並配合附圖進行詳細說明如下。In order to further explain the method of manufacturing the capsule endoscope and the lens thereof of the present invention, the following embodiments will be described in detail below with reference to the accompanying drawings.
請參閱圖1，本發明提供之膠囊內視鏡100包括一膠囊殼體110、一光學圓頂120、一鏡頭模組130、至少一光源140、一影像感測晶片150、一記憶體160、至少一電源170、一無線發射模組180及一收容腔體190。所述電源170用於給所述光源140、鏡頭模組130、影像感測晶片150、記憶體160及無線發射模組180提供電力，所述光源140用於發射光線至所述膠囊殼體110外，所述記憶體160用於存儲所述影像感測晶片150形成之影像資訊，所述無線發射模組180用於無線發射所述記憶體160中之影像資訊。其中，所述膠囊殼體110、所述光學圓頂120及所述鏡頭模組130均由生物可降解材料製成。本實施方式中，所述生物可降解材料為聚乳酸(Poly L－lactic Acid，PLA)與聚甘醇酸 (Poly Glycolic Acid，PGA)之共聚物，即聚乙丙交酯(Poly(DL－Lactic－co－Glycolic Acid)，PLGA)。另外，所述光源140、影像感測晶片150、記憶體160、電源170及無線發射模組180均收容於所述收容腔體190內。其中，所述收容腔體190係用透明且表面光滑之薄膜製成，所述薄膜由不可降解材料製成。Referring to FIG. 1 , a capsule endoscope 100 includes a capsule housing 110 , an optical dome 120 , a lens module 130 , at least one light source 140 , an image sensing chip 150 , a memory 160 , At least one power source 170, a wireless transmitting module 180, and a receiving cavity 190. The power source 170 is configured to supply power to the light source 140, the lens module 130, the image sensing chip 150, the memory 160, and the wireless transmitting module 180, and the light source 140 is configured to emit light to the capsule housing 110. The memory 160 is used to store image information formed by the image sensing chip 150. The wireless transmitting module 180 is configured to wirelessly transmit image information in the memory 160. Wherein, the capsule housing 110, the optical dome 120 and the lens module 130 are all made of biodegradable material. In this embodiment, the biodegradable material is polylactic acid (PLA) and polyglycolic acid. (Poly Glycolic Acid, PGA) copolymer, namely Poly(DL-Lactic-co-Glycolic Acid, PLGA). The light source 140 , the image sensing chip 150 , the memory 160 , the power source 170 , and the wireless transmitting module 180 are all housed in the receiving cavity 190 . Wherein, the receiving cavity 190 is made of a transparent and smooth film, and the film is made of a non-degradable material.
所述光學圓頂120位於所述膠囊殼體110之一端，所述鏡頭模組130包括一鏡座131及固定在所述鏡座131上之至少一鏡片132，所述鏡頭模組130與所述光學圓頂120相鄰設置。所述至少一光源140位於所述鏡片132之一側，本實施方式中，所述光源140為兩個發光二極體。所述無線發射模組180設置在所述膠囊殼體110內遠離所述光學圓頂120之一端。所述電源170為氯化銀電池或者可重複充放電之鋰電池。本實施方式中，所述電源170為氯化銀電池。The lens module 130 includes a lens holder 131 and at least one lens 132 fixed on the lens holder 131. The lens module 130 and the lens module 130 are disposed at one end of the capsule housing 110. The optical domes 120 are disposed adjacent to each other. The at least one light source 140 is located on one side of the lens 132. In the embodiment, the light source 140 is two light emitting diodes. The wireless transmitting module 180 is disposed within the capsule housing 110 away from one end of the optical dome 120. The power source 170 is a silver chloride battery or a lithium battery that can be repeatedly charged and discharged. In the embodiment, the power source 170 is a silver chloride battery.
優選地，所述影像感測晶片150、記憶體160通過半導體制程技術整合在一軟板上，如此可以減小體積。其中，所述影像感測晶片150為互補金屬氧化物半導體或者電荷耦合器件中之任意一種。本實施方式中，所述影像感測晶片150為電荷耦合器件。Preferably, the image sensing wafer 150 and the memory 160 are integrated on a flexible board by semiconductor processing technology, so that the volume can be reduced. The image sensing wafer 150 is any one of a complementary metal oxide semiconductor or a charge coupled device. In this embodiment, the image sensing wafer 150 is a charge coupled device.
當所述膠囊內視鏡100被吞入生物體內後，便可以通過光源140發出之光線照明體內，所述影像感測晶片將所述鏡頭模組130拍攝到之體內情況形成影像資訊，並將該影像資訊存儲在所述記憶體160內，所述膠囊內視鏡100 會忠實地記錄所述鏡頭模組130在體內拍攝到之一切畫面，從食道一直到小腸及大腸，最後直到電源170沒電，且所述膠囊殼體110、光學圓頂120、鏡頭模組130在體內降解，而收容腔體190可以使其他不可降解之元件作為一整體隨著生物體正常代謝而排除體外。After the capsule endoscope 100 is swallowed into the living body, the light emitted by the light source 140 can be used to illuminate the body, and the image sensing chip forms image information in the image captured by the lens module 130, and The image information is stored in the memory 160, the capsule endoscope 100 All the images captured by the lens module 130 in the body will be faithfully recorded, from the esophagus to the small intestine and the large intestine, and finally until the power source 170 is depleted, and the capsule housing 110, the optical dome 120, and the lens module 130 Degradation in the body, and the receiving cavity 190 can cause other non-degradable components as a whole to be excluded from the body as the organism is normally metabolized.
可以理解，所述膠囊內視鏡100也可以不包括所述收容腔體190，這樣所有不可降解之元件也可隨著生物體正常代謝而排除體外。It can be understood that the capsule endoscope 100 may not include the receiving cavity 190, so that all non-degradable components can also be excluded from the body according to the normal metabolism of the organism.
請一併參閱圖2及圖3，為本發明提供之上述膠囊內視鏡之鏡片132之製造方法，其包括以下步驟：步驟S10：提供一第一基板210；本實施方式中，所述第一基板210為鋁板。2 and FIG. 3, a method for manufacturing the lens of the capsule endoscope lens 132 according to the present invention includes the following steps: Step S10: providing a first substrate 210; in this embodiment, the A substrate 210 is an aluminum plate.
步驟S20：在所述第一基板210上進行加工，形成複數突起之微鏡結構211；步驟S30：在第一溫度下用塗層材料塗布在所述第一基板210上，經過第一時間段硬化形成與所述微鏡結構211對應之具有複數凹陷之微結構221之第二基板220；本實施方式中，所述塗層材料為二甲基矽氧烷，所述第一溫度為125攝氏度，所述第一時間段為15分鐘。Step S20: processing on the first substrate 210 to form a plurality of protrusions of the micromirror structure 211; Step S30: coating the first substrate 210 with a coating material at a first temperature, after the first period of time Forming a second substrate 220 having a plurality of recessed microstructures 221 corresponding to the micromirror structure 211; in the embodiment, the coating material is dimethyl methoxyoxane, and the first temperature is 125 degrees Celsius. The first time period is 15 minutes.
步驟S40：將所述第二基板220從所述第一基板210上分離；本實施方式中，所述第二基板220由二甲基矽氧烷材料製成。Step S40: separating the second substrate 220 from the first substrate 210. In the embodiment, the second substrate 220 is made of a dimethyl siloxane material.
步驟S50：在第二溫度下在所述第二基板220上塗布生物可降解材料，經過第二時間段硬化形成由生物可降解 材料製成之具有複數微鏡結構231之第三基板230；本實施方式中，所述第二溫度為60攝氏度，所述第二時間段為30分鐘。Step S50: coating the biodegradable material on the second substrate 220 at a second temperature, and forming a biodegradable material after hardening for a second period of time. The third substrate 230 having the plurality of micromirror structures 231 is made of a material; in the embodiment, the second temperature is 60 degrees Celsius, and the second time period is 30 minutes.
步驟S60：將所述第三基板230上之複數微鏡結構231經過切割得到複數鏡片132。Step S60: cutting the plurality of micromirror structures 231 on the third substrate 230 to obtain a plurality of lenses 132.
上述膠囊內視鏡，因為所述膠囊殼體、光學圓頂及鏡頭模組均可以在生物體內降解，所以整個膠囊內視鏡之體積減小，更容易排出體外。In the above capsule endoscope, since the capsule casing, the optical dome and the lens module can be degraded in the living body, the volume of the entire capsule endoscope is reduced, and it is easier to be discharged from the body.
上述膠囊內視鏡之鏡片之製造方法簡單，容易實現，因為鋁板較容易加工，所以應用鋁板先做出第一基板，再通過所述第一基板用二甲基矽氧烷製成第二基板，且二甲基矽氧烷這種材料價格較低，故可以降低生產成本。The method for manufacturing the lens of the capsule endoscope is simple and easy to implement. Since the aluminum plate is easier to process, the first substrate is first formed by using the aluminum plate, and the second substrate is made of dimethyl methoxyoxane through the first substrate. And the price of this material of dimethyloxane is lower, so the production cost can be reduced.
綜上所述，本發明確已符合發明專利之要件，遂依法提出專利申請。惟，以上所述者僅為本發明之較佳實施方式，自不能以此限制本案之申請專利範圍第。舉凡熟悉本案技藝之人士援依本發明之精神所作之等效修飾或變化，皆應涵蓋於以下申請專利範圍第內。In summary, the present invention has indeed met the requirements of the invention patent, and has filed a patent application according to law. However, the above description is only a preferred embodiment of the present invention, and it is not possible to limit the scope of the patent application of the present invention. Equivalent modifications or variations made by persons skilled in the art in light of the spirit of the present invention are intended to be included in the scope of the following claims.
膠囊內視鏡‧‧‧100Capsule endoscope ‧‧100
膠囊殼體‧‧‧110Capsule shell ‧‧‧110
光學圓頂‧‧‧120Optical dome ‧‧120
鏡頭模組‧‧‧130Lens module ‧‧‧130
鏡座‧‧‧131Mirror holder ‧‧131
鏡片‧‧‧132Lens ‧‧‧132
光源‧‧‧140Light source ‧‧‧140
影像感測晶片‧‧‧150Image Sensing Wafer ‧‧‧150
記憶體‧‧‧160Memory ‧‧160
電源‧‧‧170Power supply ‧‧170
無線發射模組‧‧‧180Wireless transmitter module ‧‧‧180
收容腔體‧‧‧190Containment cavity ‧ ‧ 190
第一基板‧‧‧210First substrate ‧‧‧210
微鏡結構‧‧‧211、231Micromirror structure ‧‧‧211, 231
第二基板‧‧‧220Second substrate ‧‧‧220
微結構‧‧‧221Microstructure ‧ ‧ 221
第三基板‧‧‧230Third substrate ‧ ‧ 230
圖1為本發明提供之膠囊內視鏡之內部結構示意圖。FIG. 1 is a schematic view showing the internal structure of a capsule endoscope provided by the present invention.
圖2為圖1之膠囊內視鏡之鏡片之製造方法之流程圖。2 is a flow chart of a method of manufacturing the lens of the capsule endoscope of FIG. 1.
圖3為圖1之膠囊內視鏡之鏡片之製造方法之原理示意圖。3 is a schematic view showing the principle of a method for manufacturing a lens of the capsule endoscope of FIG. 1.
膠囊內視鏡‧‧‧100Capsule endoscope ‧‧100
膠囊殼體‧‧‧110Capsule shell ‧‧‧110
光學圓頂‧‧‧120Optical dome ‧‧120
鏡頭模組‧‧‧130Lens module ‧‧‧130
鏡座‧‧‧131Mirror holder ‧‧131
鏡片‧‧‧132Lens ‧‧‧132
光源‧‧‧140Light source ‧‧‧140
影像感測晶片‧‧‧150Image Sensing Wafer ‧‧‧150
記憶體‧‧‧160Memory ‧‧160
電源‧‧‧170Power supply ‧‧170
無線發射模組‧‧‧180Wireless transmitter module ‧‧‧180
收容腔體‧‧‧190Containment cavity ‧ ‧ 190
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030208107A1 (en) * | 2000-01-13 | 2003-11-06 | Moshe Refael | Encapsulated medical imaging device and method |
| US20030139661A1 (en) * | 2001-01-22 | 2003-07-24 | Yoav Kimchy | Ingestible device |
| US20060004255A1 (en) * | 2002-09-30 | 2006-01-05 | Iddan Gavriel J | In-vivo sensing system |
| CN201042429Y (en) * | 2006-07-10 | 2008-04-02 | 钟一鸣 | Controlled mobile radio pill type endoscopic system |
Also Published As
| Publication number | Publication date |
|---|---|
| TW201016182A (en) | 2010-05-01 |
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