TWI371447B - Radiotherapy enhancer having a pyridine derivative as an active ingredient - Google Patents
Radiotherapy enhancer having a pyridine derivative as an active ingredientInfo
- Publication number
- TWI371447B TWI371447B TW095111531A TW95111531A TWI371447B TW I371447 B TWI371447 B TW I371447B TW 095111531 A TW095111531 A TW 095111531A TW 95111531 A TW95111531 A TW 95111531A TW I371447 B TWI371447 B TW I371447B
- Authority
- TW
- Taiwan
- Prior art keywords
- active ingredient
- pyridine derivative
- radiotherapy enhancer
- radiotherapy
- enhancer
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/69—Two or more oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0038—Radiosensitizing, i.e. administration of pharmaceutical agents that enhance the effect of radiotherapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2005105938 | 2005-04-01 | ||
JP2005219119 | 2005-07-28 |
Publications (2)
Publication Number | Publication Date |
---|---|
TW200714588A TW200714588A (en) | 2007-04-16 |
TWI371447B true TWI371447B (en) | 2012-09-01 |
Family
ID=37073534
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TW095111531A TWI371447B (en) | 2005-04-01 | 2006-03-31 | Radiotherapy enhancer having a pyridine derivative as an active ingredient |
Country Status (12)
Country | Link |
---|---|
US (2) | US20090137640A1 (zh) |
EP (1) | EP1864974B1 (zh) |
JP (1) | JP5103170B2 (zh) |
KR (1) | KR101135789B1 (zh) |
AU (1) | AU2006231809B2 (zh) |
BR (1) | BRPI0608327A2 (zh) |
CA (1) | CA2603810C (zh) |
HK (1) | HK1118807A1 (zh) |
NZ (1) | NZ562048A (zh) |
RU (1) | RU2415670C2 (zh) |
TW (1) | TWI371447B (zh) |
WO (1) | WO2006106984A1 (zh) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1864974B1 (en) * | 2005-04-01 | 2013-10-09 | Taiho Pharmaceutical Company Limited | Potentiator for radiation therapy comprising pyridine derivative as active ingredient |
KR20120015318A (ko) * | 2009-05-12 | 2012-02-21 | 다이호야쿠힌고교 가부시키가이샤 | 테가푸르?기메라실?오테라실칼륨 배합제 및 옥살리플라틴을 함유하는 항종양제 |
CA2895526C (en) | 2012-12-20 | 2021-08-24 | Qing-bin LU | Radiosensitizer compounds for use in combination with radiation |
BR102013022567B1 (pt) * | 2013-09-03 | 2021-09-21 | Uniao Brasileira De Educacão E Assistência | Uso de 6-hidroxi-2-piridonas e seus derivados na preparação de uma composição farmacêutica que atue pela inibição da enzima uridina fosforilase humana |
CA3182871A1 (en) * | 2020-06-15 | 2021-12-23 | Kortuc Inc. | Sensitizer for cancer treatment |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6122016A (ja) * | 1984-07-10 | 1986-01-30 | Adeka Argus Chem Co Ltd | 放射線増感剤 |
JPS61109719A (ja) * | 1984-10-31 | 1986-05-28 | Otsuka Pharmaceut Co Ltd | 抗腫瘍活性増強剤 |
EP0180188B1 (en) * | 1984-10-30 | 1992-04-15 | Otsuka Pharmaceutical Co., Ltd. | A composition for increasing the anti-cancer activity of an anti-cancer compound |
JP2531952B2 (ja) * | 1987-04-06 | 1996-09-04 | 大塚製薬株式会社 | フオスホリラ−ゼ阻害剤 |
ATE455187T1 (de) * | 2001-07-05 | 2010-01-15 | Taiho Pharmaceutical Co Ltd | Dna-arrays zur messung der empfindlichkeit gegenüber einem antikrebsmittel |
RU2334517C2 (ru) * | 2003-03-14 | 2008-09-27 | Тайхо Фармасьютикал Ко., Лтд. | Средство, потенцирующее противоопухолевый эффект, и противоопухолевое средство |
EP1864974B1 (en) * | 2005-04-01 | 2013-10-09 | Taiho Pharmaceutical Company Limited | Potentiator for radiation therapy comprising pyridine derivative as active ingredient |
AU2006231808B2 (en) * | 2005-04-01 | 2010-06-24 | Taiho Pharmaceutical Co., Ltd. | Radiotherapy enhancer |
-
2006
- 2006-03-31 EP EP06730909.6A patent/EP1864974B1/en active Active
- 2006-03-31 TW TW095111531A patent/TWI371447B/zh not_active IP Right Cessation
- 2006-03-31 CA CA2603810A patent/CA2603810C/en not_active Expired - Fee Related
- 2006-03-31 US US11/910,150 patent/US20090137640A1/en not_active Abandoned
- 2006-03-31 AU AU2006231809A patent/AU2006231809B2/en not_active Ceased
- 2006-03-31 NZ NZ562048A patent/NZ562048A/en not_active IP Right Cessation
- 2006-03-31 RU RU2007140384/15A patent/RU2415670C2/ru active
- 2006-03-31 WO PCT/JP2006/306961 patent/WO2006106984A1/ja active Application Filing
- 2006-03-31 KR KR1020077025043A patent/KR101135789B1/ko not_active IP Right Cessation
- 2006-03-31 JP JP2007511214A patent/JP5103170B2/ja not_active Expired - Fee Related
- 2006-03-31 BR BRPI0608327-7A patent/BRPI0608327A2/pt not_active IP Right Cessation
-
2008
- 2008-09-04 HK HK08109853.9A patent/HK1118807A1/xx unknown
-
2010
- 2010-12-27 US US12/978,743 patent/US8569324B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP1864974A1 (en) | 2007-12-12 |
AU2006231809B2 (en) | 2011-08-25 |
CA2603810C (en) | 2012-06-26 |
BRPI0608327A2 (pt) | 2009-12-29 |
EP1864974A4 (en) | 2009-09-02 |
WO2006106984A1 (ja) | 2006-10-12 |
JP5103170B2 (ja) | 2012-12-19 |
CA2603810A1 (en) | 2006-10-12 |
US8569324B2 (en) | 2013-10-29 |
EP1864974B1 (en) | 2013-10-09 |
HK1118807A1 (en) | 2009-02-20 |
US20090137640A1 (en) | 2009-05-28 |
KR20080002900A (ko) | 2008-01-04 |
AU2006231809A1 (en) | 2006-10-12 |
RU2007140384A (ru) | 2009-05-10 |
KR101135789B1 (ko) | 2012-04-16 |
TW200714588A (en) | 2007-04-16 |
RU2415670C2 (ru) | 2011-04-10 |
JPWO2006106984A1 (ja) | 2008-09-25 |
NZ562048A (en) | 2011-12-22 |
US20110091016A1 (en) | 2011-04-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Annulment or lapse of patent due to non-payment of fees |