B11909 九、發明說明： 【發明所屬之技術領域】 本發明係關於一種微生理訊號收集裝置，特別是關於一 種貼片（patch)式無線（wireless)微生理訊號收集裝置。 【先前技術】 心跳、腦波、呼吸、體溫等訊號均是生命跡象的指標， 醫療院所、安養中心以及各式照護都不可或缺。若能更容 易取得這些生理訊號相關資訊，將有助於各式照護的進 行’除了可以節省人力成本外，另可提高醫療照護品質， 甚至可以推廣至個人照護，故相關微生理訊號的取得，一 向為重要的醫療發展方向。 圖1係例示一心跳之心電圖（electrocardiogram ; ECG)訊 號’一般而言將其最尖端的波段稱為QRS波，其中首先向 上偏折的點為Q點，在頂端為r點，而最後於底端處稱為S 點。於QRS辨認程序中首先以尖峰檢測程序將微生理訊號 中的QRS波找出，且從每個QRS波中測量其高度（ampHtude) 和持續時間（duration)等參數，並將各參數之平均值和標準 差算出，用以作為標準模版。接下來每個QRS波都以此模 版進行比對。 心率變異性（heart rate variability ; HRV)分析是從心跳週 期數列分析心臟生理功能的方法，標準的分析程序已在 1 996由歐美心臟學會所定義（Task F〇rce 〇f the European Society of Cardiology and the North American Society of Pacing and Electrophysiology，1996)，之後經過一些修改 106661發明專利說明書.d〇c 13 Γ1909 (Kuo et al.，1999)，大致原理如下： 1.首先取得心跳週期的資訊，其大部份的作法是從心電圖 的R波定義每一心跳的發生，而每—R波與後一個R波的 時間差就是一個心跳週期RR。 2.如果連續的RR數列中有大幅度的變動，譬如超過三個標 準差，可能是心率不整或是雜訊。若是前者，應立即提B11909 IX. Description of the Invention: [Technical Field] The present invention relates to a microphysiological signal collecting device, and more particularly to a patch type wireless microphysiological signal collecting device. [Prior Art] Heartbeat, brainwave, respiration, body temperature and other signals are indicators of signs of life. Medical institutions, security centers and various types of care are indispensable. If it is easier to obtain information about these physiological signals, it will help all kinds of care to be carried out. In addition to saving labor costs, it can improve the quality of medical care, and even can be extended to personal care. Therefore, the acquisition of micro-physiological signals is related. Has always been an important direction of medical development. Figure 1 illustrates an electrocardiogram (ECG) signal. In general, the most advanced band is called a QRS wave, where the point of the first upward deflection is the Q point, the top point is the r point, and finally the bottom. The end is called the S point. In the QRS identification process, the QRS wave in the microphysiological signal is first found by the spike detection program, and the parameters such as height (ampHtude) and duration (duration) are measured from each QRS wave, and the average of each parameter is obtained. And standard deviation calculation, used as a standard template. Each QRS wave is then compared against this template. Heart rate variability (HRV) analysis is a method for analyzing cardiac physiological function from a series of heartbeat cycles. The standard analysis procedure has been defined by the European and American Heart Association in 1996 (Task F〇rce 〇f the European Society of Cardiology and The North American Society of Pacing and Electrophysiology, 1996), after some modifications to the 106661 invention patent specification. d〇c 13 Γ 1909 (Kuo et al., 1999), the general principles are as follows: 1. First get the information of the heartbeat cycle, its large Part of the practice is to define the occurrence of each heartbeat from the R wave of the electrocardiogram, and the time difference between each R wave and the latter R wave is a heartbeat period RR. 2. If there is a large change in the continuous RR series, for example, more than three standard deviations, it may be a heart rate irregularity or noise. If it is the former, it should be mentioned immediately
出警訊’因受測者的生命可能受到咸脅；若是後者，應 改良測量分析的技術以克服之。 3.如果連續的RR數列中沒有大幅的變動，則這些尺尺數列 可進行更細緻的數值分析，包括頻譜分析（Ku〇 d al 1999)與非線性分析（Kuo & Yang，2002)等。 睡眠分期主要依賴腦電波、肌電波及眼動圖而加以區 隔。若能簡易進行睡眠分期即有機會了解許多睡眠相關疾 病之發生及預防。單純腦電波的量測即可以了解許多疾病 之發生，如癲癇、老年痴呆症等，若另加測量呼吸訊號則 可進一步了解是否有睡眠呼吸相關疾病發生，如睡眠呼吸 中止症。另外若外加心率或心率變異性分析，更可深入了 解睡眠與高血壓之相關性，睡眠生理訊號監測及分析將是 臨床醫學不可或缺的生理訊號，此訊號測量的普及化有助 於許多疾病的預防、監測及疾病的診斷。 呼吸速率在臨床上常作為生命跡象指標之一，當呼吸越 快則體内代謝速率越快，其通常係因面臨危急、緊張、生 病情況。呼吸頻率訊號容易由溫度計測量鼻氣息，即經由 鼻孔呼出氣體測量溫度而得到，並且為心率變異性及血壓 106661發明專利說明書.d〇c Ϊ311909 變異)·生之重要的影響因子。經呼吸校正後的心率變異性， 可得到更精確的評估（Chen et ai，，。 體溫在臨床常作為生命跡象指標之一，f體溫越高則體 内代Π射速率越快，通常也因為面臨生病情況。額溫的測量 為體/皿測量之常用且方便的指標。若能連續監測將有利於 病情變化之了解、減少醫護相關人力、更減少交又感染的 可能性。 Φ 大部分的生理訊號收集系統，皆須一條以上導線，雖訊 號可以精確，但因需在受測者身上連接許多電線，受測時 不能亂動，故不但接線耗時，也造成受測者的不便，更無 法讓觉測者自由活動。近年來隨著科技的進步，半導體跟 無線傳輸的技術都很發達，微小化偵測生理訊號產品陸續 被k出已實現所谓「隨身型（ambulatory)」的生理訊號收 集裝置，其可以大小約如手掌，有些可以連續將生理訊號 儲存在内部的記憶體中，有些甚至可以及時將生理訊號以 Φ 無線電波或紅外線傳輸到遠方的接收器中，讓外界可以及 時知道爻測者的身體狀況，這些技術讓偵測生理訊號的應 用更加的方便而有彈性。然而這些儀器的體積還是太大， 重量還疋太重，尤其是接線的方式對一般未受訓者來說還 是太複雜。這些電線雖然已經很短了，仍會造成使用者的 些不便。所以目前這些隨身型的收集生理訊號儀器基本 上還是屬於醫療儀器，需要專家從旁指導才能正確配戴， 仍不是一般人可以自由使用的消耗性電子產品。 果〇人想將生理訊號分析技術更廣泛的推廣到每一個 106661發明專利說明書d〇c 1311909 家庭與個人，必須克服目前各類固定式或攜帶式生理儀器 的種種不便，微小化與徹底的無線化將是必然的發展方向。 【發明内容】 為避免習知的問題’本發明揭示一種完全無線的貼片式 微生理訊號收集裝置，以利各類微生理訊號的分析。 該貼4式無線微生理訊號收集裝置操作包含一電極 (electrode)、一放大器（amplifier)模組、—微控制器㈤⑽ ^ controller)、一無線電模組及一電源供應器。 該電極為為一具有正電極與負電極之雙極差分設計，該 正電極與負電極之係貼片式設計，其中該正電極與負電極 之貼片下方更分別包含一雙面膠設計之導電膠膜，經由該 導電膠膜黏合受測者之體表面產生導電接觸，用以收集受 ' 測者的微生理訊號。該放大器模組接收來自該正電極與負 電極的雙極輸入訊號後，先經由一輸入級濾波器濾除雜訊 以增加§ίΙ號雜訊比（signal t0 n〇ise rati〇 ; SNR)，再經由一 • 差分放大器進行差分放大，產生一放大微生理訊號。該放 大微生理訊號再經由一輸出級濾、波器排除該微控制器之類 比數位取樣兩倍頻率以上之訊號，以利該微控制器之類比 數位取樣。該微控制器之類比數位轉換單元以適當的電壓 解析度與取樣率將來自該放大器模組產生的放大微生理訊 號做類比至數位轉換，再以_微處理運算單元進行資料壓 縮而產生一數位微生理訊號。該無線電模組接收來自微控 制器產生的數位微生理訊號，經一調變/解調變器 (modulator/de moduIator)調變為一調變微生理訊號。該調變 106661發明專利說明書.doc I31H09 微生理訊號經-無線收發器以—無線微生理訊號發射至遠 端。同時該無線電模組也可以該無線收發器接收來自遠端 的無線訊號。 該貼片式無線微生理訊號收集裝置可包含—外層防水膠 膜或外層包覆防水設計，使微生理訊號收集裝置具防水功 能，讓受測者於從事各項活動時更自由。The warning is that the life of the subject may be threatened by salt; if the latter, the techniques of measurement and analysis should be improved to overcome it. 3. If there are no large changes in the continuous RR series, these scales can be analyzed in more detail, including spectrum analysis (Ku〇 d al 1999) and nonlinear analysis (Kuo & Yang, 2002). Sleep staging is mainly dependent on brain waves, myoelectric waves, and eye movements. If you can easily perform sleep staging, you will have the opportunity to understand the occurrence and prevention of many sleep-related diseases. Simple brainwave measurements can be used to understand the occurrence of many diseases, such as epilepsy, Alzheimer's disease, etc. If you add a measurement of respiratory signals, you can further understand whether there are sleep-related respiratory diseases, such as sleep-disordered breathing. In addition, if you add heart rate or heart rate variability analysis, you can further understand the correlation between sleep and hypertension. Sleep physiological signal monitoring and analysis will be an indispensable physiological signal for clinical medicine. The popularization of this signal measurement will help many diseases. Prevention, monitoring and diagnosis of diseases. Respiratory rate is often used as one of the indicators of life in clinical practice. The faster the breathing, the faster the metabolic rate in the body, which is usually due to critical, stressful, and ill conditions. The respiratory rate signal is easily measured by a thermometer, that is, the temperature is measured by exhaling gas through the nostrils, and is a heart rate variability and blood pressure. 106661 invention patent specification. d〇c Ϊ311909 variation). Respiratory corrected heart rate variability can be more accurately assessed (Chen et ai,, body temperature is often used as one of the indicators of life in the clinic, the higher the body temperature, the faster the in vivo firing rate, usually because Faced with sickness. The measurement of the frontal temperature is a common and convenient indicator for body/dish measurement. Continuous monitoring will help to understand the changes in the condition, reduce the labor related to the medical care, and reduce the possibility of infection and infection. Φ Most of the The physiological signal collection system requires more than one wire. Although the signal can be accurate, it is necessary to connect a lot of wires to the subject, and it can not be tampering when it is tested. Therefore, not only the wiring is time-consuming, but also the inconvenience of the subject. It is impossible for the sensory to move freely. In recent years, with the advancement of technology, the technology of semiconductor and wireless transmission has been developed, and the products of miniaturized physiological signals have been implemented to realize the so-called "ambulatory" physiological signals. The collecting device can be about the size of a palm, and some can continuously store physiological signals in internal memory, and some can even receive physiological signals in time. The number is transmitted to the remote receiver by Φ radio waves or infrared rays, so that the outside world can know the physical condition of the tester in time. These techniques make the application of detecting physiological signals more convenient and flexible. However, the volume of these instruments is still too large. Big, the weight is too heavy, especially the way of wiring is still too complicated for the untrained. Although these wires are already very short, it will cause some inconvenience to the user. So the current physiological signals of these portable types are collected. The instrument basically belongs to the medical instrument, and it needs the expert to guide it to wear it properly. It is still not a consumable electronic product that the average person can use freely. The person wants to spread the physiological signal analysis technology more widely to each 106661 invention patent specification. D〇c 1311909 Families and individuals must overcome the inconveniences of various types of fixed or portable physiological instruments. Miniaturization and thorough wirelessization will be an inevitable development direction. [Summary of the Invention] The invention discloses a completely wireless patch type microphysiological signal collecting device, Analysis of micro-physiological signals. The operation of the type 4 wireless micro-physiological signal collecting device comprises an electrode, an amplifier module, a microcontroller (5) (10) ^ controller), a radio module and a power supply. Device. The electrode is a bipolar differential design having a positive electrode and a negative electrode. The positive electrode and the negative electrode are in a chip-type design, wherein the positive electrode and the negative electrode are respectively covered with a double-sided adhesive design. The conductive adhesive film is electrically connected to the surface of the subject through the conductive adhesive film to collect the microphysiological signal of the subject. After receiving the bipolar input signal from the positive electrode and the negative electrode, the amplifier module filters the noise through an input stage filter to increase the signal t0 n〇ise rati〇 (SNR). A differential amplification is then performed through a differential amplifier to generate an amplified microphysiological signal. The amplified micro-physiological signal is then subjected to an output level filter and a wave filter to exclude signals of the analog controller that are more than twice the frequency of the digital sampling to facilitate analog sampling of the microcontroller. The analog digital conversion unit of the microcontroller analogizes the amplified microphysiological signal generated by the amplifier module to digital conversion with appropriate voltage resolution and sampling rate, and performs data compression by the _micro processing unit to generate a digital position. Microphysiological signal. The radio module receives the digital microphysiological signal generated by the micro controller and is modulated into a modulated microphysiological signal by a modulator/de moduator. The modulation is in accordance with the patent specification. doc I31H09 The microphysiological signal-radio transceiver transmits to the far end with a wireless microphysiological signal. At the same time, the radio module can also receive the wireless signal from the far end by the wireless transceiver. The patch-type wireless micro-physiological signal collecting device may comprise an outer layer waterproof film or an outer layer covering waterproof design, so that the micro-physiological signal collecting device has a waterproof function, so that the subject is more free to engage in various activities.
。隨著半導體技術的進步，本發明之貼片式無線微生理訊 號收集裝置具備進—步縮小化的潛力，可將電極、放大器 模組、微控制器、無線電模組與電源供應器的所有電路整 合到—片電路板，甚至是一顆晶片（chip)内。 本發明的優點包括：⑴微生理訊號收集裝置為無線且體 積小’攜帶與使用皆方便。⑺貼片兩邊連接點正好可收集 正負端的生理訊號，使生理訊號收集方便且可靠。⑺貼片 兩邊連接點適提供足夠黏力以固定微小生理儀器，使黏貼 更可靠易固定且不易掉落。（4)貼片式生理訊號收集裝置可 完全配合受測者過去已有用0K端黏貼傷口的習慣，因簡單 容易且人人皆有使用經驗，所以有機會可推廣至受測者的 自打使用’甚至可普及至老人及小孩。(5)由於使用材料簡 早，什以低成本大量製造，可滿足醫療用品拋棄式的要求， 適用於两危險或高感染疾病之監測；⑨了可長時間監測病 情之外，更可以節省人力成本’及減少醫護人員受到感染 的機會。⑻具防水功能，讓受測者於從事各項活動時更自 由導電膠膜可時常更換’以免於受測者因長久接觸皮 膚而造成發炎。 106661發明專利說明書.doc 1311909 本發明之貼片式無線微生理訊號收集裝置可應用的範圍 包括心電$、腦波儀、肌電儀、額溫計、溫度計、鼻孔氣 息測量儀等，若將上述各式整合則可成為—種多功能睡眠 δ乡療儀，無任何接線的睡眠與自主神經分析系統得以實現。 【實施方式】 圖2係本發明實施例之貼片式無線微生理訊號收集裝置 20之方塊示意圖。該貼片式無線微生理訊號裝置2〇包含一 電極201、一放大器模組2〇2、一微控制器2〇3、一無線電模 組204及一電源供應器205。 該貼片式無線微生理訊號收集裝置可包含一如〇κ繃之 外層防水膠膜或外層包覆防水設計2〇6，使整套設計可兼顧 防水功能’讓受測者於從事各項活動時更自由。 電極201為一具有正電極2〇13與負電極2〇ib之雙極差分 設計。正電極20 la與負電極201b係貼片式設計，整體造型 如OK繃，可直接連接到受測者2〇〇身上，用以收集受測者 200的微生理訊號。 該電極201可以黏貼於該受測者的不同部位以收集不同 的微生理訊號。例如··黏貼在胸前以收集心電訊號及胸前 溫度；黏貼在額頭以收集腦電波圖及動眼訊號或額溫訊 號；黏貼在下巴以收集肌電訊號；或黏貼在鼻孔出口以收 集鼻孔氣息及呼吸訊號。 該放大器模組202包含一對輸入級濾波器202a、一差分放 大器202b與一輸出級濾波器202c。該放大器模組202接收來 自該正電極20 la與負電極201b的雙極輸入訊號後，先經由 106661發明專利說明書.d〇c -10- 13 Π 909. With the advancement of semiconductor technology, the patch-type wireless micro-physiological signal collecting device of the present invention has the potential of further step-down, and can be used for all circuits of electrodes, amplifier modules, microcontrollers, radio modules and power supplies. Integrated into a chip board, or even a chip. Advantages of the present invention include: (1) The microphysiological signal collecting device is wireless and small in size, and is convenient to carry and use. (7) The connection points on both sides of the patch can collect the physiological signals of the positive and negative ends, so that the physiological signal collection is convenient and reliable. (7) Patch The connecting points on both sides are suitable for providing sufficient adhesion to fix tiny physiological instruments, making the adhesive more reliable, easy to fix and not easy to fall. (4) The patch-type physiological signal collecting device can fully cooperate with the testee's past habit of sticking the wound with the 0K end. Because of the simplicity and easy experience of everyone, there is an opportunity to promote it to the subject's self-use. It can even be popularized to the elderly and children. (5) Due to the use of materials, it can be manufactured at low cost and can meet the requirements of disposable medical products. It can be used for monitoring two dangerous or high-infected diseases. 9 It can save manpower in addition to monitoring the disease for a long time. Cost' and reduce the chances of health care workers being infected. (8) It has a waterproof function, so that the subject can change the conductive film more easily when performing various activities to prevent the subject from being inflamed due to prolonged contact with the skin. 106661 invention patent specification. doc 1311909 The patch type wireless micro-physiological signal collecting device of the present invention can be applied to include ECG, brain wave meter, myoelectric meter, thermometer, thermometer, nostril measuring instrument, etc. The above-mentioned various integrations can be used as a multi-functional sleep δ physiotherapy instrument, and a sleep and autonomic nervous analysis system without any wiring can be realized. [Embodiment] FIG. 2 is a block diagram showing a patch type wireless micro-physiological signal collecting device 20 according to an embodiment of the present invention. The SMD wireless micro-physiological signal device 2 includes an electrode 201, an amplifier module 2〇2, a microcontroller 2〇3, a radio module 204, and a power supply 205. The patch type wireless micro-physiological signal collecting device may comprise a waterproof film or a double-layer waterproofing design of the outer layer of the 〇κ 〇 , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , More free. The electrode 201 is a bipolar differential design having a positive electrode 2〇13 and a negative electrode 2〇ib. The positive electrode 20 la and the negative electrode 201b are in a patch-like design, and the overall shape, such as OK stretch, can be directly connected to the subject 2 to collect the microphysiological signal of the subject 200. The electrode 201 can be attached to different parts of the subject to collect different microphysiological signals. For example, stick to the chest to collect the ECG signal and chest temperature; stick it on the forehead to collect the brain wave map and eye movement signal or temperature signal; stick it on the chin to collect the myoelectric signal; or stick it on the nostril outlet to collect the nostrils Breath and breath signal. The amplifier module 202 includes a pair of input stage filters 202a, a differential amplifier 202b and an output stage filter 202c. The amplifier module 202 receives the bipolar input signal from the positive electrode 20 la and the negative electrode 201 b, and then passes the 106661 patent specification. d〇c -10- 13 Π 909
該輸入級濾波器202a濾除雜訊以增加訊號雜訊比，再經由 该差分放大器202b進行差分放大，產生一放大微生理訊 號。5玄差如放大器202b —方面將共模（common mode)之雜訊 衰減’另一方面將差異（differential)之微生理訊號以適當的 倍率放大，以配合該微控制器203之類比數位轉換的電壓範 圍。該放大微生理訊號再經由該輸出級濾波器202c排除奈 奎斯頻率（Nyquist frequency)(即該微控制器之類比數位轉 換中取樣頻率的兩倍）以上之訊號，以利該微控制器2〇3之 類比數位取樣。此外，該放大器模組2〇2之輸入端阻抗大於 200kQ，以避免錯誤動作可能產生的漏電。該輸入級濾波 器202a、輸出級濾波器202c可由電阻與電容類被動元件構 成，該差分放大器202b可由積體電路式之運算放大器或儀 測放大器構成。 該微控制器203包含一類比數位轉換單元2〇3a與一微處 理運算單元203b。該類比數位轉換單元2〇3a以適當的電壓 解析度與取樣率將來自該放大器模組202產生的放大微生 理訊號做類比至數位轉換，再以該微處理運算單元2〇3b進 行資料壓縮’產生一數位微生理訊號。 該無線電模組204包含一無線收發器204a與一調變/解調 變器204b ’該無線電模組204與微控制器203相連的輸入端 為串列式或並列式之數位通道，接收來自微控制器2〇3產生 的數位微生理訊號’並經該調變/解調變器2〇4]3調變為以 2.4GHz為載波（carrier)之調變微生理訊號。該調變微^生理訊 號經該無線收發器204a以一無線微生理訊號發射至遠端。 106661發明專利說明書.d〇c '1311909 同時該無線收發器204a亦可接收來自遠端的無線訊號，經 該調變/解調變器204b解調變為數位資料訊號後，再經該數 位通道傳給微控制器203。來自遠端的無線訊號包含該無線 微生理訊號收集裝置20的控制訊號與遠方接收器所發出的 確認（acknowledge)訊號。該確認訊號的應用例如：來自該 微控制器203經資料壓縮並加上適當的標記後的數位微生 理號，以數位通道傳送到該無線電模組2 〇 4進行無線微生 理訊號的發射輸出’透過接收遠方接收器所發出的確認訊 遗’可碟保無線微生理訊號資料輸出的完整。該無線電模 組204以國際標準之工業、科學、醫療（industry Science Medical ; ISM)專用之的2.4GHz頻段進行無線電發射與接 收。 電源供應器205可為一微型電池或一太陽能電源，用以提 供該貼片式無線微生理訊號收集裝置2〇内所有電路的電 源。 圖3(a)、圖3(b)與圖3(c)所示係根據本發明實施例之貼片 式無線微生理訊號收集裝置之結構分解示意圖。 圖3 (a)所示為一多層電路板構造之分解示意圖，分為電路 板層301、302和3 03三層，每一層均包含一上表面與一底表 面，微控制器203與無線電模組204配置於電路板層3〇1上表 面’放大器模組202配置於電路板層302上表面，電路板層 303之底表面電極層3〇3a包含一第一電極303 al與一第二電 極303a2，如圖3(e)所示，該電源供應器2〇5可經由第一電極 303al與第二電極3〇3a2進行充電。 106661發明專利說明書doc -12- •1311909 該電極層303a上之第一電極303al及第二電極3〇3a2分別 與該正電極20la及負電極20lb貼片上的連接點201c及2〇id 電氣相連接’該連接點201c與20Id可以為鈕扣式或平面金 屬接點。 該正電極20 la與負電極20 lb之貼片下方更分別包含一導 電膠膜2016與201£，導電膠膜2016與2015可設計為以雙面勝 方式貼於正電極201a與負電極201b之貼片，經由該導電膠 膜201e與201 f黏合受測者之體表面產生導電接觸，以收集 該雙極的電訊號。依此導電膠膜2〇1 e與20If可時常更換， 以免於受測者200因長久接觸皮膚而造成發炎。 無線電模組204配置於最上層之電路板層3 〇 1有助於無線 訊號的發射與接收。由於電路板層3〇1的微控制器2〇3與無 線電模組204電路可能干擾位於電路板層3〇2之放大器模組 202的訊號，在電路板層3〇1的底表面加上一層隔離接地面 3〇la ’將有助位於電路板層3〇2的放大器模組2〇2提高其類 比線路之訊號雜訊比。電源供應器2〇5可配置於電路板層 302底表面與電路板層303上表面之間，電路板層3〇2的底表 面了直接接觸到電源供應器2 0 5上的正或負其中一極作為 電源層，而電路板層303的上表面則直接接觸到電源供應器 205的另一極作為另一電源層。 隨著半導體技術的進步’可將電路板層3〇1和3〇2兩層上 之兀件202、203和204合併於同一電路板層311中。如圊3(b) 所示。此外’甚至電路板層3〇丨、302和3〇3中之元件202、 203、204和205可進一步合併於同一電路板層321中，據此 106661發明專利說明書化 -13- 1311*909 電路板層321上表面的所有元件202、203、204和205可以整 合到一顆晶片内，如圖3(c)所示。 所有圖3(a)、3(b)及3(c)所實現的電路與電極其外型如圖 3(d)所示之一貼片式結構内。 電源供應器205可如圖3(a)所示置於電路板層303與302之 間’或如圖3(b)所示置於電路板層303與3 11之間，其將有助 於電極201隔離來自微控制器203與無線電模組204電路的 干擾電波。另一方面將電源供應器205置於較下層有助於整 體重心的降低，增加該貼片式無線微生理訊號收集裝置2〇 與受測者200黏合的穩定性。 本發明之貼片式無線微生理訊號收集裝置可應用的範圍 包括心電儀、腦波儀、肌電儀、額溫計、溫度計、鼻孔氣 息測量儀等，若將上述各式整合則可成為一種多功能睡眠 診療儀，無任何接線的睡眠與自主神經分析（Yang et ai., 2002; Yang et al.s 2003; Kuo et al., 2004; Kuo et al., 2004; Kuo & Yang，2〇〇4)系統得以實現。 本發明之技術内容及技術特點已揭示如上，然而熟悉本 項技術之人士仍可能基於本發明之教示及揭示而作種種不 背離本發明精神之替換及修飾。因此，本發明之保護範圍 應不限於實施例所揭示者，而應包括各種不背離本發明之 替換及修飾，並為以下之申請專利範圍所涵蓋。 【圖式簡單說明】 圖1係例示一心跳之心電圖訊號； 圖2係本發明之貼片式無線微生理訊號收集裝置之方塊 106661發明專利說明書.dl •14- ί311909 示意圖； 圖3⑷、圖3⑻與圖3(c)所示係根據本發明之實施例之貼 片式無線心電收集裝置結構分解示意圖； 圖3⑷所係、根據本發明之實施例之貼片式無線微生理 訊號收集裝置之外型結構示意圖；以及 圖3(e)係根據本發明之實施例之電極層示意圖。 【主要元件符號說明】The input stage filter 202a filters out noise to increase the signal to noise ratio, and then differentially amplifies through the differential amplifier 202b to generate an amplified microphysiological signal. 5 mystery, such as amplifier 202b, attenuates the noise of the common mode. On the other hand, the differential microphysiological signal is amplified at an appropriate magnification to match the analog-to-digital conversion of the microcontroller 203. voltage range. The amplified microphysiological signal is further eliminated by the output stage filter 202c by a signal above a Nyquist frequency (ie, twice the sampling frequency in the digital conversion of the microcontroller) to facilitate the microcontroller 2 〇3 is analogous to digital sampling. In addition, the input impedance of the amplifier module 2〇2 is greater than 200kQ to avoid leakage current that may occur due to malfunction. The input stage filter 202a and the output stage filter 202c may be formed of a resistor and a capacitor-like passive element, and the differential amplifier 202b may be constituted by an integrated circuit type operational amplifier or a sense amplifier. The microcontroller 203 includes an analog-to-digital conversion unit 2〇3a and a micro-processing unit 203b. The analog-to-digital conversion unit 2〇3a analogizes the amplified microphysiological signal generated by the amplifier module 202 to digital conversion with appropriate voltage resolution and sampling rate, and performs data compression by the micro processing unit 2〇3b. A digital microphysiological signal is generated. The radio module 204 includes a wireless transceiver 204a and a modulation/demodulation transformer 204b. The input terminal of the radio module 204 and the microcontroller 203 is a serial or side-by-side digital channel, and receives the micro channel. The digital microphysiological signal generated by the controller 2〇3 is modulated by the modulation/demodulation transformer 2〇4]3 into a modulated microphysiological signal with a carrier of 2.4 GHz. The modulated micro-physiological signal is transmitted to the remote end via the wireless transceiver 204a by a wireless micro-physiological signal. 106661 invention patent specification. d〇c '1311909 At the same time, the wireless transceiver 204a can also receive the wireless signal from the remote end, and the digital signal is demodulated by the modulation/demodulation transformer 204b into a digital data signal, and then through the digital channel. It is passed to the microcontroller 203. The wireless signal from the far end includes the control signal of the wireless microphysiological signal collecting device 20 and an acknowledge signal sent by the remote receiver. The application of the confirmation signal is, for example, a digital micro-physiological number from the microcontroller 203 that is compressed by the data and appropriately labeled, and transmitted to the radio module 2 〇4 by the digital channel for transmitting and outputting the wireless micro-physiological signal. By receiving the confirmation message sent by the remote receiver, the integrity of the wireless micro-physiological signal data output can be guaranteed. The radio module 204 performs radio transmission and reception in the 2.4 GHz band dedicated to the industry, industry, and medical (ISM) standards of international standards. The power supply 205 can be a miniature battery or a solar power source for providing power to all circuits in the SMD wireless micro-physiological signal collecting device 2 . 3(a), 3(b) and 3(c) are schematic exploded views showing the structure of a patch type wireless microphysiological signal collecting apparatus according to an embodiment of the present invention. Figure 3 (a) shows an exploded schematic view of a multi-layer circuit board structure, divided into three layers of circuit board layers 301, 302 and 303, each layer comprising an upper surface and a bottom surface, the microcontroller 203 and the radio The module 204 is disposed on the upper surface of the circuit board layer 3〇1. The amplifier module 202 is disposed on the upper surface of the circuit board layer 302. The bottom surface electrode layer 3〇3a of the circuit board layer 303 includes a first electrode 303 al and a second surface. The electrode 303a2, as shown in FIG. 3(e), can be charged via the first electrode 303a1 and the second electrode 3?3a2. 106661 Patent Specification doc -12- • 1311909 The first electrode 303a1 and the second electrode 3〇3a2 on the electrode layer 303a are respectively connected to the connection points 201c and 2〇 of the positive electrode 20la and the negative electrode 20lb. Connections 'The connection points 201c and 20Id can be button or flat metal contacts. The positive electrode 20 la and the negative electrode 20 lb are respectively covered with a conductive adhesive film 2016 and 201 respectively. The conductive adhesive films 2016 and 2015 can be designed to be attached to the positive electrode 201 a and the negative electrode 201 b in a double-sided manner. The patch is electrically contacted to the surface of the body of the subject via the conductive adhesive films 201e and 201f to collect the electrical signals of the bipolar. Accordingly, the conductive films 2〇1 e and 20If can be replaced from time to time to prevent the subject 200 from being inflamed due to prolonged contact with the skin. The radio module 204 is disposed on the uppermost circuit board layer 3 〇 1 to facilitate the transmission and reception of wireless signals. Since the microcontroller 2〇3 and the radio module 204 circuit of the board layer 3〇1 may interfere with the signal of the amplifier module 202 located at the board layer 3〇2, a layer is added to the bottom surface of the board layer 3〇1. The isolated ground plane 3〇la' will help the amplifier module 2〇2 located on the board layer 3〇2 to increase the signal-to-noise ratio of its analog line. The power supply 2〇5 can be disposed between the bottom surface of the circuit board layer 302 and the upper surface of the circuit board layer 303, and the bottom surface of the circuit board layer 3〇2 directly contacts the positive or negative of the power supply 205. One pole serves as a power supply layer, and the upper surface of the circuit board layer 303 directly contacts the other pole of the power supply 205 as another power supply layer. With advances in semiconductor technology, the germanium members 202, 203, and 204 on the two layers of the circuit board layers 3〇1 and 3〇2 can be combined in the same circuit board layer 311. As shown in 圊3(b). Furthermore, even the elements 202, 203, 204 and 205 of the circuit board layers 3, 302 and 3〇3 can be further incorporated in the same circuit board layer 321, whereby the 106661 invention patent specification-13-1311*909 circuit All of the elements 202, 203, 204, and 205 on the upper surface of the ply 321 can be integrated into one wafer as shown in Figure 3(c). All of the circuits and electrodes implemented in Figures 3(a), 3(b) and 3(c) have a form factor as shown in Figure 3(d). The power supply 205 can be placed between the circuit board layers 303 and 302 as shown in Figure 3(a) or placed between the circuit board layers 303 and 3 11 as shown in Figure 3(b), which will help The electrode 201 isolates interference waves from the microcontroller 203 and the radio module 204 circuitry. On the other hand, placing the power supply 205 on the lower layer contributes to the reduction of the whole body weight, and increases the stability of the patch type wireless microphysiological signal collecting device 2 黏 bonding to the subject 200. The applicable range of the patch type wireless microphysiological signal collecting device of the present invention includes an electrocardiograph, an electroencephalograph, an electromyograph, a thermometer, a thermometer, a nostril measuring instrument, etc., if the above various types are integrated, the A multifunctional sleep diagnosis and treatment instrument with no sleep and autonomic analysis (Yang et al., 2002; Yang et al.s 2003; Kuo et al., 2004; Kuo et al., 2004; Kuo & Yang, 2〇〇4) The system is implemented. The technical contents and technical features of the present invention have been disclosed as above, and those skilled in the art can still make various substitutions and modifications without departing from the spirit and scope of the invention. Therefore, the scope of the present invention should be construed as being limited by the scope of the appended claims. BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a diagram showing an electrocardiogram signal of a heartbeat; FIG. 2 is a block diagram of a patch type wireless microphysiological signal collecting apparatus of the present invention. 106661 Patent Description. dl • 14- ί 311909 Schematic diagram; FIG. 3 (4), FIG. 3 (8) FIG. 3(c) is a schematic exploded view of a patch-type wireless electrocardiographic collecting device according to an embodiment of the present invention; FIG. 3(4) is a patch-type wireless microphysiological signal collecting device according to an embodiment of the present invention; Schematic diagram of the outer structure; and Fig. 3(e) is a schematic view of an electrode layer according to an embodiment of the present invention. [Main component symbol description]
20無線微生理訊號收集裝置 200 受測者 201 電極20 wireless microphysiological signal collecting device 200 subject 201 electrode
201a 正電極 201c 正電極與上層電； 連接點 201e 導電膠膜 202 放大器模組 202b差分放大器 203 微控制器 203b 微處理運算單元 204a 無線收發器 205 電源供應器 206外層防水膠膜或外層 301 、 302 、 303 、 311 、 321 301a 隔離接地面 303a 電路板層303之底表 201b 負電極 201d 負電極與上層電極 層連接點 201f 導電膠膜 2 0 2 a 輸入級滤波器 202c 輸出級濾波器 203a 類比數位轉換單元 204 無線電模組 204b 調變/解調變器 包覆防水設計 電路板層 面電極層 106661發明專利說明書.doc •15· 1311909 303al 第一電極 303a2 第二電極201a positive electrode 201c positive electrode and upper layer; connection point 201e conductive film 202 amplifier module 202b differential amplifier 203 microcontroller 203b microprocessor unit 204a wireless transceiver 205 power supply 206 outer layer waterproof film or outer layer 301, 302 , 303 , 311 , 321 301a isolation ground plane 303a circuit board layer 303 bottom table 201b negative electrode 201d negative electrode and upper electrode layer connection point 201f conductive film 2 0 2 a input stage filter 202c output stage filter 203a analog digital Conversion unit 204 radio module 204b modulation/demodulation transformer coated waterproof design circuit board layer electrode layer 106661 invention patent specification.doc •15· 1311909 303al first electrode 303a2 second electrode
106661發明專利說明書.doc106661 invention patent specification.doc