TW518233B - Composition for use as cosmetics - Google Patents

Abstract

A compositions for external use comprising succinog1ucan and a water-swelling clay mineral, which is useful particularly as cosmetics. The composition can give a novel feeling upon use which satisfies the diversified requirements by consumers and is excellent in long-term stability.

Description

518233 五、發明說明α) llij月之領域 本發明歸屬於關於外用組成物之技術領域的範圍内。尤 其’其係關於一種使用時的感覺優異，具有長期安定性， 且尤其有用作為化粧品之外用組成物。 發明之背景 、近年來人們，尤其係年輕人，偏好使用使皮膚滋潤柔 軟，且在使用時賦予清爽感覺的化粧品。此趨勢不塑 到護膚產品，並且影響到護體產品及化粧產品。 …曰 為在使用時獲致前述的感覺，此等產品一般包含 基聚合物為又稠劑及安定劑。然而，在含易離子化二匕合 =料1 如化粧抗產壞口灰酸主、磷酸鎖、精胺酸鹽酸鹽）之產品或: ηπ匕化合物或顏料之嚴重抑制。結果，產生：此問 題，诸如钻度減低，在儲存過程中 一 等產品的長期安定性不利。降’其使得此 為解決此等問題，在一些情況中使用辦 膠及羥乙基纖維素。雖然可日稠“诸如頁酸树 人滿意的長期安定性，= = =而獲致令 題。 名見泥摩或黏腻的另一問 在此等情況下，現有產品在使 之間並無太大不肖，因&，其並^及其形態彼此 化的需求。 “、、套水通滿足消費者多樣 因此，本發明之一目的在於提 如，化粧品等等），其在使用可、/卜用組成物（例 了賦予新穎的感覺，因而 m\6\51.pid 518233 五、發明說明（2) 可滿足消費者多樣化的需求，且具有良好的長 I8月之農’ ° 、為解決前述問題，本發明人進行廣泛的研究。結果，其 成功地發現一種尤其可有用作為化粧品的外用組成物，^ 在使用時可展現不同於現有化粧品的新穎感覺（賦予滋潤、 感’與皮膚高度相容，產生極度清爽的感覺等等），且^ ϊ Ϊ:!間内保持安定而不會有黏度減低，可經由使用琥油 ，來糖及遇水膨脹的黏土礦物作為羧乙烯基聚合物之替代 品用於增稠及安定化而達到分離或沈降，因而完 明。 八十把 因此，本發明提供一種包含琥珀葡聚糖及遇 礦物之外用組成物。 在使用時展現更佳感覺的外用組成物可經由更將油性成 二=至前述之組成物中而達到。此外，本發明之期望效果 ':由將表面活性劑、丙烯酸烷酯•甲基丙烯 =至組成物’尤其係包含油性成份之組成物中而有效： 以下將進一步說明本發明。 根據本發明之外用組成物(以下簡稱為「本發明之組成 」〇 3琥珀葡聚糖及遇水膨脹黏土礦物。 ，用於本發明之組成物中的琥$白葡聚糖係產生於微生物 ^騎。換言<，其意指包含衍生自半乳糖及葡萄糖之糖 =以及何生自琥珀酸、丙酮酸之酸單元，及作為非必需 成伤之乙酸、或此_ 〆 瓜之產生於微生物的多膽。518233 V. Description of invention α) Field of llij month The present invention belongs to the technical field of composition for external use. In particular, it relates to a product which is excellent in feeling during use, has long-term stability, and is particularly useful as a composition for external use in cosmetics. BACKGROUND OF THE INVENTION In recent years, people, especially young people, prefer to use cosmetics that make the skin moist and soft and give a refreshing feeling when used. This trend does not mold skin care products and affects body care products and makeup products. … In order to obtain the aforementioned feeling during use, these products generally contain base polymers as thickeners and stabilizers. However, in products containing easily ionizable dagger compounds (such as make-up, anti-detrimental, uric acid main, phosphate lock, spermine hydrochloride) or: Severe inhibition of ηπ dagger compounds or pigments. As a result, problems such as reduced drillability and poor long-term stability of first-class products during storage are generated. It makes this possible. To solve these problems, gum and hydroxyethyl cellulose are used in some cases. Although it can be thick and thick, such as the long-term stability that Sagittarius satisfies, = = = and it gets the question. Seeing muddy or sticky another question In these cases, the existing products are not too difficult to make. It's a big mistake, because of the need to combine it with its form. ",, sets of water to meet the diversity of consumers. Therefore, one of the objects of the present invention is to mention, such as cosmetics, etc." The composition for use (for example, it gives a novel feeling, so m \ 6 \ 51.pid 518233 V. Description of the invention (2) It can meet the diversified needs of consumers and has a good long agricultural period of August. To solve the foregoing problems, the present inventors have conducted extensive research. As a result, they have successfully found an external composition that is particularly useful as a cosmetic, and can exhibit a novel sensation (improving moisture, sensation, and skin) different from existing cosmetics when used. Highly compatible, producing an extremely refreshing feeling, etc.), and ^ ϊ Ϊ :! It stays stable within a while without viscosity reduction. It can be polymerized as carboxyvinyl through the use of soybean oil, sugar and water-swelling clay minerals. Substitution of things It is used for thickening and stabilization to achieve separation or sedimentation, so it is clear. Eighty handles Therefore, the present invention provides a composition for external use containing succinodextran and minerals. A composition for external use that exhibits a better feeling during use This can be achieved by further reducing the oiliness to the aforementioned composition. In addition, the desired effect of the present invention ': from the surfactant, the alkyl acrylate • methacrylic acid = to the composition' is particularly a composition containing an oily ingredient It is effective in the composition: The present invention will be further described below. According to the composition for external use of the present invention (hereinafter referred to as "the composition of the present invention") succinoglucan and water-swellable clay mineral. The succinic gluconate is produced by microorganisms. In other words, it means that it contains sugar units derived from galactose and glucose = and succinic acid units derived from succinic acid and pyruvate, and as a non-essential Injury acetic acid, or this is the bile produced by microorganisms.

518233 五、發明說明（3) 尤其，琥珀葡聚糖係由半乳糖單元、葡萄糖單元、琥珀 酸單元及丙顯I酸單元（莫耳比：1 : 7 : 〇 · 8 : 1 )，視需要與乙 酸單元一起組成之水溶性聚合物，其具有以約6，〇 〇 〇，〇 〇 〇 以上較佳之重量平均分子量（以自約6，〇 〇 〇，〇 〇 〇至約 1 5，0 0 0，0 0 0更佳），其係由以下結構式所表示。 4) (0ls3) (β!% 4) (βΐ, 4)518233 V. Description of the invention (3) In particular, the succindextran system is composed of galactose unit, glucose unit, succinic acid unit and glycine acid unit (Mole ratio: 1: 7: 0.8 · 1), as required A water-soluble polymer composed of acetic acid units, which has a weight average molecular weight of preferably about 6,000,000 or more (from about 6,000,000 to about 15,000). 0, 0 0 0 is more preferred), which is represented by the following structural formula. 4) (0ls3) (β!% 4) (βΐ, 4)

Giuc^uc^jalac-Gluc-Giuc ^ uc ^ jalac-Gluc-

Ο Ϊ Gluc-Gluc-Gluc-GlocΟ Ϊ Gluc-Gluc-Gluc-Gloc

(filsi) (β1,0 在上式中’各Glue代表葡萄糖單元，而各Galac代 乳糖單元。在醣單元之間的鍵結方式指示於括號中。 如’（/3 1，4)代表万1 一4鍵。 表半 例(filsi) (β1,0 In the above formula, 'each Glue represents a glucose unit, and each Galac is a lactose unit. The way of bonding between sugar units is indicated in parentheses. For example,' (/ 3 1, 4) represents ten thousand 1 to 4 keys. Table half example

產生破拍葡聚糖之微生物的例子包括屬於假單胞菌屬、 根瘤菌屬、產驗菌屬及土壤桿菌屬之微生物。其中，屬於 土壤桿菌屬的根癌土壤桿菌卜736為特佳，其已於1 988年3 月1日在布達佩斯條約下交給國家微生物培養收集（CNCM ; ^ection Nationale de Cultures de Microorganism) 保官，且可以編號I — 7 3 6公開取得。 玻轴葡聚糖可經由在培養基中培養此一微生物而產生。 尤其丄琥珀葡聚糖可經由在一般含有碳來源（例如，葡 糖、蔬糖、水解殺粉等等）、有機氮來源（例如，酪蛋 、路蛋白鹽、植物粉末、酵母萃取物、玉米浸液（CSL)Examples of microorganisms that produce destructive glucan include microorganisms belonging to the genus Pseudomonas, Rhizobium, Proteus, and Agrobacterium. Among them, Agrobacterium tumefaciens 736, which belongs to the genus Agrobacterium, is particularly preferred, which was handed over to the National Microbial Culture Collection (CNCM; ^ ection Nationale de Cultures de Microorganism) under the Budapest Treaty on March 1, 1988. , And can be obtained publicly under the number I — 7 3 6. The glass axis glucan can be produced by culturing such a microorganism in a culture medium. In particular, succinate dextran can be obtained from sources that generally contain carbon (eg, glucose, vegetable sugar, hydrolyzed powder, etc.), organic nitrogen sources (eg, casein, road protein salt, plant powder, yeast extract, corn Immersion fluid (CSL)

518233518233

五、發明說明（4) 等等）及無機鹽（例如，金屬硫酸鹽、金屬磷酸鹽、金屬石山 酸鹽等等），視需要並含有微量元素之培養基中培養微 A 物而製得。 在1至4巴（bar)之壓力在25至35 °C之溫度在需氧條件 下’例如，進行攪拌下，培養微生物一般為較佳。培養 之PH值係自5至9，以6至8較佳。 、土 於培養完成後，可將培養基加熱，然後與有機溶劑諸如 異丙醇連續接觸，以使琥珀葡聚糖沈澱。為自培養^分^ 破j葡聚糖，經由過濾收集琥拍葡聚糖隨後再‘離二7並5. Description of the invention (4), etc.) and inorganic salts (for example, metal sulfate, metal phosphate, metal stone mountain salt, etc.) are prepared by culturing micro-A substances in a medium containing trace elements as needed. At a pressure of 1 to 4 bar at a temperature of 25 to 35 ° C under aerobic conditions', for example, culture of microorganisms is generally preferred with stirring. The pH of the culture is from 5 to 9, preferably 6 to 8. After the culture is completed, the culture medium may be heated and then continuously contacted with an organic solvent such as isopropyl alcohol to precipitate succindextran. In order to self-cultivate ^ saccharose dextran, collect sucrose dextran through filtration and then ‘离 二 7 和

在同壓下乾燥而產生可使用於本發明之組成物中的琥茴 聚糖為較佳。 間 毋庸头a ，可將如此製得之琥珀葡聚糖以原樣使用於4 ir月i!成物中。或者，若須要，其可經由酸降解， :π -素降解、施加超音波等等進一步降解，並可將如出 製付之降解產物使用於本發明之組成物中。 直t ί ί明之組成物中的琥珀葡聚糖含量以組成物之總< =:且：胳〇 . 01至1 5. 〇重量百分比較佳。當琥珀葡聚糖含1 二、=之總重量計落在0.1至10.0重量百分比之範圍内It is preferred to dry under the same pressure to produce succinolan which can be used in the composition of the present invention. In spite of this, the succinodextran thus prepared can be used as it is in the product of 4 months. Alternatively, if necessary, it can be further degraded by acid degradation, π-degradation, application of ultrasonic waves, etc., and degradation products such as those produced can be used in the composition of the present invention. The content of succindextran in the composition is preferably based on the total content of the composition < =: and: 0.1 to 15.0% by weight. When the total weight of succinate dextran contains 1 2 and = falls within the range of 0.1 to 10.0 weight percent

:之i膠形i發明之組成物係呈展現進-步改良長期安焚 以組成物之總重| _彳 今晋if X a二 十低於0· 〇1重量百分比之琥珀葡； 含里並不佳，由於在肤，卜主: The composition of the i-gum i invention presents a further improvement of the long-term safety of the composition to the total weight of the composition | _ 晋 今 晋 if X a Twenty less than 0 · 〇1 weight percentage of amber; Not good, because in the skin, Bu Zhu

玄枨。甘人曰 月/兄中組成物僅具有不良的長I 疋性。其含量超過15· 〇 ^ 细占必7 4 h 4 2上 里百分比亦不佳’由於在此十 組成物會變黏並在使用睥 ^ ^ 用守產生令人不悅的感覺。Xuanzang. Gan people said that the composition in the month / brother had only poor long-term properties. Its content exceeds 15 · 〇 ^ fine accounted for 7 4 h 4 2 and the percentage is not good ’because the ten components here will become sticky and produce unpleasant sensations during use.

518233 五、發明說明（5) 之：：於本發；之組成物中的遇水膨脹黏土礦物並無特殊 ’只要其係可在水中膨脹之黏土礦物即可。具有； 。、、、成之天然或合成的黏土礦物皆可供其使用。 = Μ例子包括蒙脫wctites)諸如 脫二了領石、4 土、料脫石、貝得石（beideUite) ^石（nontronite)、辞蒙脫石及富鎂蒙脫石；及膨脹雲… 士發明之組成物可包含此等遇水膨脹黏土礦 或其之兩者以上的組合。 有 在本發明之組成物中的遇水膨脹黏土 ::rr自°·。1至15.°重量百分比之】 ^，物之總重量計自〇.1至1〇.〇重量百分比又較佳。者 =月=i礦物=含量以組成物之總重量計低於0.01田重量 、刀比挎，所製得之組成物僅展現不良的長 過1 5. 0重量百分比之遇水膨脹黏土礦物之含 s 於幾乎無法得到具有根據本發明之特性的組成物不么’由 本發明之組成物可更包括在化粧品及/或 之載體、稀釋劑、賦形劑等等。 ’、 义 除了號轴葡聚糖及遇水膨脹黏土礦物之 成物尚包含油性成份較佳。加人油性成份可& 皮膚上非常優異的可擴展性，更為改良的滋 因而產生當使用作為，尤其係化粧品時 ：：”， 感覺的產品。 ，、有更令人喜好 使用於本發明之組成物中的油性成份並無特殊之限制，518233 V. Description of the invention (5): In the present invention, the water-swellable clay mineral in the composition is not special, as long as it is a clay mineral that can swell in water. Have; Natural clay or synthetic clay minerals can be used. Examples of Μ include montmorillonite (wctites) such as detached collar stones, 4 soils, bentonite, beideUite ^ stone (nontronite), montmorillonite and magnesium-rich montmorillonite; and swelling clouds ... The composition may include these water-swellable clay minerals or a combination of two or more thereof. Water-swellable clays in the composition of the present invention :: rr from ° ·. 1 to 15. °% by weight], the total weight of the substance is preferably from 0.1 to 10.0% by weight. Where = month = imineral = content is less than 0.01% by weight based on the total weight of the composition. Containing s makes it almost impossible to obtain a composition having characteristics according to the present invention. The composition of the present invention may further include cosmetics and / or carriers, diluents, excipients, and the like. ’, Meaning In addition to the horn glucan and water-swellable clay minerals, the product contains oily ingredients. Adding oily ingredients can & very good expandability on the skin, more improved odors are produced when used as, especially for cosmetics: "", a product that feels like. ", There are more preferred to use in the present invention There are no special restrictions on the oily ingredients in the composition,

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518233 、發明說明（6) :、要其係可使用於外用組成物諸如化粧品中即可。可使用 2體成份或固體成份。油性成份之例子包括液體油類諸如 ，，噩，油、山茶油、海龜油、澳洲堅果仁油（macadamia nut 、玉米油、貂油、撖欖油、油菜籽油、蛋黃油、芝麻 ί:杏仁油、|芽精油、茶梅油、萬麻油、亞麻仁油、紅 棉軒油、.蘇子油、黃豆油、花生油、茶杆油、柩 _、米糠：、中國桐油、日本桐油、荷荷M(jojoba 酸畤蜱5牙油、三辛酸甘油酉1、三異棕櫚酸甘油酯、異辛 ;=曰、肉豆謹酸異丙醋、液態石壤、角業院、異石 、甲苯基聚石夕氧、油醇及2_辛基十二醇； 二 =及堪諸如可可脂、椰子油、馬脂、硬化椰子 ，、牛脂、羊脂、硬化牛脂、棕櫊仁油、豬油、 卞月如、日本躐仁油、硬化、、山 麻油、蜂蝶、小燭樹躐、棉〗、二腳脂、曰本蠛二硬化萬 ^ ii > rn > 巴西棕櫚堪、桂貫蠍、昆 羊毛脂褐；t、米_、羊毛脂、木棉花油、醋酸 月曰 /夜恕羊毛脂、玉米諸棰由络 酸、月桂己i旨、還原羊毛脂、1X異丙基羊毛脂脂肪 壤、膽留醇、植物留醇、:;曰:η、硬羊毛脂、蟲膠 醇、山签舻 备匕把 π日日鼠、山俞醇、硬脂醇、鯨蠟 山則酸、硬脂酸及肉豆蔻酸。 本發明之組成物可包含此等 者以上的組合。 成伤之任一者或其之兩 在本發明之組成物中的油性 計在自0 · 1至4 〇 · 0重量百分比之έ 1以組成物之總重量 總重量計自0.3至3U重 1内較佳，以組成物之 里曰刀比又較佳。油性成份之含518233, Description of the invention (6): It can be used in external composition such as cosmetics. Can be used as a 2-body or solid ingredient. Examples of oily ingredients include liquid oils such as, oil, camellia oil, turtle oil, macadamia nut, corn oil, mink oil, olive oil, rapeseed oil, egg butter, sesame seeds: almonds Oil, | bud essential oil, tea plum oil, sesame oil, linseed oil, red cotton oil, .seed oil, soybean oil, peanut oil, tea stick oil, 柩, rice bran :, Chinese tung oil, Japanese tung oil, lotus M (jojoba acid tick 5 tooth oil, tricaprylyl glycerol 1, triisopalmitate glyceride, isooctyl; =, isopropyl myristate, liquid stone soil, horn industry, isolith, toluene Polyester oxygen, oleyl alcohol and 2-octyldodecanol; two = and can be such as cocoa butter, coconut oil, horse fat, hardened coconut, tallow, lamb fat, hardened tallow, palm kernel oil, lard,卞 月 如, Japanese coix seed oil, hardened, sesame oil, bee butterfly, candelilla pupa, cotton〗 Lanolin brown; t, rice _, lanolin, kapok oil, acetic acid month / Yeshu lanolin, corn Zhuyouyouluo acid, Laurel, i.e. reduced lanolin, 1X isopropyl lanolin fatty soil, bileurol, phytosterol,:; η, hard lanolin, shellac, mountain lottery dagger , Behenyl alcohol, stearyl alcohol, cetyl behenic acid, stearic acid, and myristic acid. The composition of the present invention may include a combination of these or more. Any one or two of the wounds are in the present invention The oiliness of the composition is preferably from 0. 1 to 4 0. 0 weight percent. 1 Based on the total weight of the composition, the total weight is from 0.3 to 3 U. Weight 1 is better. Better. Containing oily ingredients

518233 五、發明說明（7) 量以組成物之總重量計低於〇1重量 在此情況中組成物在皮膚上之可擴刀並不利，由於 其含量超過40· 〇重量百分比』 並…、法獲得改良。 中會因清爽感覺的退化而在使用時展現此情況 本發明之組成物以更包含夺良的感見。 性劑可進一步改良本發明之^物的=父佳。加入表面活 在此-情;兄，將表面活性劑加 到高長期安定性較佳。 今’“之組成物中，以達 使明之組成物中的表面活性劑並無特殊之限 制〜、要其係可使用於外用組成物諸如化粧品中之表面活 性劑即可。可使用非離子、陰離子、陽離子或兩性表面活 性劑。其例子包括脫水山梨糖醇脂肪酸酯、甘油或聚甘油 脂肪酉夂酯、丙二醇脂肪酸酉旨、聚氧伸乙基（以下簡稱為 POE)脫水山梨糖醇脂肪酸醋、p〇E山梨糖醇脂肪酸酯、p〇E 甘油脂肪酸酯、POE脂肪酸酯、P〇E烷基醚、p〇E烷苯基 醚、P0E /聚氧伸丙基（以下簡稱為p〇p)烷基醚、p〇E ^麻 油或硬化蓖麻油衍生物、P〇E蜂蠟羊毛脂衍生物、烷醇醯 胺、P0E丙二醇脂肪酸酯、p〇E烷基胺、p〇E脂肪酸醯胺、 嚴糠脂肪酸i旨、聚鱗變性聚矽氧、脂肪酸皂、硫酸高碳烧 酉旨鹽、烧基_硫酸自旨鹽、N -醯基肌胺酸酯、高碳脂肪酸醯 胺磺酸酯、磷酸酯鹽、磺酸琥珀酸酯、烷基苯磺酸酯、N — 醯基胺基戊二酸、烧基三甲基銨鹽、二烧基二曱基銨鹽、 口米嗤琳型兩性表面活性劑及甜菜驗型表面活性劑。518233 V. Description of the invention (7) The amount is less than 0 weight based on the total weight of the composition. In this case, the expandable knife of the composition on the skin is not favorable, because its content exceeds 40. 0 weight percent "and ..., Law was improved. This may occur during use due to the deterioration of the refreshing sensation. The composition of the present invention further includes a good feeling. Sexual agents can further improve the product of the present invention. Add surface activity here-brother; adding surfactant to high long-term stability is better. In the composition of "", there is no special limitation on the surfactant in the composition of Da Shiming ~ It is only necessary that it is a surfactant that can be used in external compositions such as cosmetics. Non-ionic, Anionic, cationic or amphoteric surfactants. Examples include sorbitan fatty acid esters, glycerol or polyglycerol fatty acid esters, propylene glycol fatty acid esters, polyoxyethylene (hereinafter referred to as POE) sorbitan fatty acids Vinegar, POE sorbitol fatty acid ester, POE glyceryl fatty acid ester, POE fatty acid ester, POE alkyl ether, POE alkylphenyl ether, POE / polyoxypropylene (hereinafter referred to as P0) alkyl ether, p0E sesame oil or hardened castor oil derivative, POE beeswax lanolin derivative, alkanolamine, POE propylene glycol fatty acid ester, pOE alkylamine, p. E fatty acid ammonium, strict bran fatty acid i, poly-scale denatured polysiloxane, fatty acid soap, sulfuric acid high-carbon burning salt, burning-sulfur acid salt, N-fluorenyl sarcosinate, high-carbon fatty acid Sulfamic acid ester, phosphate salt, sulfonic acid succinate, alkylbenzene sulfonate, N Acyl amino glutaric acid, burning trimethyl ammonium salt, di-ammonium salt burn yl two Yue, Lin laugh meter port type amphoteric surfactants and surfactants beet test.

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本發明之組成物可包含此等表面活性劑之其中一者或其 之兩者以上的組合。 在本發明之組成物中之表面活性劑的含量可適當地決 定’以不使使用時的感覺及產品的安全性退化。其含量以 組成物之總重量計在自〇 〇1至5 〇重量百分比之範圍内較 · 佳，以組成物之總重量計自〇· 〇5至2· 〇重量百分比又較 . 佳^表面活性劑之含量以組成物之總重量計低於〇 · 〇丨重量 百分^並不佳，由於在此情況中無法令人滿意地獲得改良 長期安定性的效果。其含量超過5 · 〇重量百分比亦不利， ’ 由於在此情況中組成物在使用時的感覺會退化。 本發明之組成物更包括丙烯酸烷酯•甲基丙烯酸烷酯共 聚物較佳。加入丙烯酸烷酯·甲基丙烯酸烷酯共聚物可進 一步改良組成物的長期安定性。當本發明之組成物包含油 性成份時，其長期安定性有時會退化。在此一情況中，將· 丙稀酸烧自旨•曱基丙烯酸烷酯共聚物加至本發明之組成物 -中’以獲致良好的長期安定性為特佳。 使用於本發明之組成物中的丙烯酸烷酯·曱基丙烯酸烷 酉旨共聚物並無特殊之限制，只要其係可使用於外用組成物 諸如化粧品中之丙烯酸烷酯•甲基丙烯酸烷酯共聚物即 - 可。換言之，其之烷基以及聚合度並無限制。例如，可以 β 使用 PEMULEN TR-2(BF GOODRICH 製造）。 - 在本發明之組成物中之丙烯酸烷酯•甲基丙烯酸烷酯共 聚物的含量可適當地決定，以不使使用時的感覺及產品的 安全性退化。其含量以組成物之總重量計在自0 . 0 0 5至5 . 0The composition of the present invention may include one of these surfactants or a combination of two or more thereof. The content of the surfactant in the composition of the present invention can be appropriately determined 'so as not to deteriorate the feeling during use and the safety of the product. Its content based on the total weight of the composition is preferably in the range from 0.001 to 50 weight percent, and based on the total weight of the composition is from 0.05 to 2 weight percent. Better ^ surface The content of the active agent is less than 0.00% by weight based on the total weight of the composition, which is not good, because the effect of improving long-term stability cannot be obtained satisfactorily in this case. Its content exceeding 5.0% by weight is also unfavorable, because in this case, the feel of the composition upon use is degraded. The composition of the present invention preferably includes an alkyl acrylate-alkyl methacrylate copolymer. The addition of an alkyl acrylate · alkyl methacrylate copolymer can further improve the long-term stability of the composition. When the composition of the present invention contains an oily component, its long-term stability sometimes deteriorates. In this case, it is particularly preferable to add the acrylic acid moisturizing agent and the alkyl alkyl acrylate copolymer to the composition of the present invention-to obtain good long-term stability. There are no particular restrictions on the alkyl acrylate-alkyl acrylate copolymer used in the composition of the present invention, as long as it is an alkyl acrylate-alkyl methacrylate copolymer that can be used in external-use compositions such as cosmetics. Things are-can. In other words, the alkyl group and the degree of polymerization are not limited. For example, PEMULEN TR-2 (manufactured by BF GOODRICH) can be used for β. -The content of the alkyl acrylate-alkyl methacrylate copolymer in the composition of the present invention can be appropriately determined so as not to deteriorate the feeling during use and the safety of the product. Its content is from 0.05 to 5.0 based on the total weight of the composition.

518233 五、發明說明（9) 重量百分比之範圍内較佳，以組成物之總重量 2. 0重量百分比又較佳。丙烯酸烷酯•甲基丙：fc 聚物之含量以組成物之總重量計低於〇 · 〇 〇 5重J 不佳，由於在此情況中無法令人滿意地獲得改 性的效果。其含量超過5. 0重量百分比亦不利， 情況中組成物在使用時的感覺會退化。 除了刚述之成份外，本發明之組成物尚可包 用之成份’只要本發明之效果不會因而惡化即 份之例子如下： 二二元醇諸如丙二醇、二丙二醇、丨，3— 丁二醇 " 乙一醇一乙一醇及具有較高分子量之 ，油、二甘油、三甘油及具有較高分子量之 ％諸如山梨糖醇、甘露糖醇、麥芽糖醇、 鮮 if·; 糖_諸如果糖、葡萄糖、半乳糖、麥芽糖、乳 無機粉末諸如滑石、古扁丄 ^ 金帝你 人同嶺土、雲母、知雲母 衣母、合成雲母、鱸^ 酸4Μ 七雲母、黑雲母、鋰雲母 鳃、八β 文姑、碎酸鋇、矽酸鈣、矽 金屬鎢酸鹽、鎂、惫仆访 ^ y 鈣（妒植 >、丄 氧化石夕、沸石、硫酸鋇 末、金屬皂（肉豆競酸#广灰石、羥基磷灰 化蝴； 辞、掠櫚酸約、硬脂酸！ 有私；粉末諸如聚酿脸料丨、 版树脂粉末（耐綸粉末） 計自0 · 0 1至 食酸烧酯共 t百分比並 良長期安定 由於在此 含技藝中常 可。此種成 、1，4- 丁二 —7G酉予， 聚甘油； 木糖醇及赤 糖及海藻 · 、白雲母、 、蛭石、碳 酸鎂、梦酸 — 、緞燒疏酸· 石、陶瓷粉 - S等等）及氮 、聚乙烯粉 518233518233 V. Description of the invention (9) The range of weight percentage is preferable, and the total weight of the composition is 2.0 weight percentage. The content of the alkyl acrylate and methyl propylene: fc polymer is less than 0.005 weight J based on the total weight of the composition, which is not good, because the modification effect cannot be obtained satisfactorily in this case. Its content exceeding 5.0 weight percent is also unfavorable, in which case the composition feels degraded during use. In addition to the ingredients just mentioned, the ingredients of the composition of the present invention can also be used as long as the effect of the present invention will not be deteriorated. Examples are as follows: Dihydric alcohols such as propylene glycol, dipropylene glycol, 3-butane Alcohol " Ethyl alcohol-ethylene glycol and its higher molecular weight, oil, diglycerol, triglycerol and% with higher molecular weight such as sorbitol, mannitol, maltitol, fresh if ·; Glucose, galactose, maltose, milk inorganic powders such as talc, paleo 丄β Wengu, barium acid, calcium silicate, silicon metal tungstate, magnesium, exhaustion ^ y Calcium (Yi Zhi), oxidized stone, zeolite, barium sulfate, metal soap (myristine) # 广 灰石 、 hydroxyapatite butterfly; Ci, palmitic acid, stearic acid! Private; powders such as poly-flavored face powder, resin powder (Nylon powder) Count from 0 · 0 1 to food acid Burning ester total percentage and good long-term stability It is often available in art. This kind of product is 1,4-butane-7G, polyglycerin, xylitol and sucrose, and seaweed, muscovite, ochre, magnesium carbonate, dream acid, and satin burning acid. · Stone, ceramic powder-S, etc.) and nitrogen, polyethylene powder 518233

乙烯粉末、苯乙烯/ 、聚（四氟乙烯）粉末 末、聚（甲基丙烯酸甲酯）粉末、聚苯 丙烯酸共聚物粉末、苯胍胺樹脂粉末 及纖維素粉末； 無機白色顏料諸如二氧化名 如鐵之氧化物(紅色氧化鐵)及鈦 辛益：機丨色顏料諸 r -氧化鐵’· μ黃色顏料氧化: '色顏料諸如 無機黑色顏料諸如里色氧化㈣^乳化鐵及百色褚石； 機紫色顏料諸如鐘；及銘紫;载心=低次元氧化鈦；無 氫氧化鉻及鈦酸銘；零色：士綠色顏料諸如氧化鉻、 珍珠顏料諸如塗布氧』：㊁；料^群青及普魯士藍；Ethylene powder, styrene /, poly (tetrafluoroethylene) powder, poly (methyl methacrylate) powder, polyphenylacrylic acid copolymer powder, benzoguanamine resin powder and cellulose powder; inorganic white pigments such as dioxide name Such as iron oxide (red iron oxide) and titanium Xinyi: organic pigments r-iron oxide 'μ μ yellow pigment oxidation:' color pigments such as inorganic black pigments such as iridium oxide ^ emulsified iron and Baise Chushi Organic purple pigments such as clocks; and Ming Zi; load center = low-order titanium oxide; no chromium hydroxide and titanate Ming; zero color: green pigments such as chromium oxide, pearl pigments such as coated oxygen ": ㊁; material And Prussian Blue;

鉍、塗布氧化鈦之滑石、有色涂:布巩化鈦之虱化氧 秘及魚鱗’·金屬粉末顏料諸母' 氯化氧 紅色201號、紅色202號、紅牟及銅粉；有機顏料諸如 22 0號、紅色22 6號、紅色228味5虎、紅色205號、紅色 號、橙色204號、黃色205號、'二，色4„〇5號、橙色203 锆、鋇或鋁色澱之有機顏料二0 1唬及藍色4 0 4號；含 色1 〇 6號、紅色2 2 7號、红色2^紅色3 5虎、紅色1 0 4號、紅 號、橙色20 5號、黃色4號、^號、紅色401號、紅色5〇5 20 3號、綠色3號及藍色丨於·汽5號、黃色202號、黃色 胡蘿蔔素； & ,天然著色劑諸如葉綠素及冷—Bismuth, talc coated with titanium oxide, tinted coating: Oxygenation of titanium oxide and fish scale '· metal powder pigments' Oxygen chloride red 201, red 202, red mou and copper powder; organic pigments such as 22 0, red 22 6, red 228 5 tiger, red 205, red, orange 204, yellow 205, 'two, color 4'〇5, orange 203 zirconium, barium or aluminum lake Organic pigments 0 01 and blue 4 0 4; color 1 0 6; red 2 2 7; red 2 ^ red 3 5 tiger; red 10 4; red; orange 20 5; yellow No. 4, ^, red 401, red 505 20 3, green 3 and blue 丨 Yu · 5, yellow 202, yellow carotene; & natural colorants such as chlorophyll and cold—

植物性聚合物諸如合金I 樹膠、稻子豆膠、刺梧桐樹ς、^膠、半乳聚糖、古阿 角菜；微生物聚合物諸如主二二D藍膠（gellan⑼"1)及鹿 物；動物聚合物諸如膠蛋=^树膠、葡聚糖、及澱粉聚合 、路蛋白、白蛋白及明膠；澱Plant-based polymers such as Alloy I gum, rice bean gum, sycamore tree gum, gum, galactan, and ancient carrageen; microbial polymers such as gellan⑼ " 1 and deer; Animal polymers such as gum eggs, gum, dextran, and starch polymerization, road proteins, albumin, and gelatin;

518233 五、發明說明（11) ^^ 粉聚合物諸如叛甲基殿粉及甲基羥内基澱粉、 物諸如曱基纖維素、乙基纖維素、曱基羥丙基纖 J及合 乙基纖維素、纖維素硫酸鈉、羥丙基纖維素、緩、’、素、羥 素鈉及結晶纖維素；海藻酸聚合物諸如海藻酸=I基纖維 海藻酸酯；乙烯基聚合物諸如聚乙烯醇、=乙酸 內二醇 聚乙烯基曱基醚、聚乙烯基吡咯啶鲷、乙稀基:^，醋、 乙酸乙烯酯共聚物及羧乙烯基聚合物；丙烯酸系=/ 如聚丙烯酸鈉、聚丙烯酸乙酯、聚丙烯酸烷醇胺，^ =諸 烯酸烷酯/甲基丙烯酸二曱基胺乙酯共聚物、聚（2—基丙 醢胺基-2-甲基丙石黃酸）及聚曱基丙烯酿基氧三^其歸 試劑諸如紫外光吸收劑、螯合劑、維生素、殺n 發炎劑、防腐劑、植物萃取物及清涼劑；及 Θ 几 低奴醇诸如乙醉及異丙醇。 本發明之組成物可塗布至皮膚、頭髮等等。本發 成物可呈各種形態，包括水溶液系統、溶解系統:乳劑系 統、油性液體系統、凝膠系統、軟膏系統、氣溶膠、水 油兩層系統及水/油/粉末三層系統。雖然本發明之組成 物尤其可有用作為化粧品’但其亦可有用作為藥品、類藥 品^等。當將本發明之組成物使用作為基礎化链品時，可 ί護膚精油(化粧水）、乳液、乳膏、凝膠等等。 組成物使用作為修飾化粧品時，可將其加工 成：使用‘二睫毛貧、化裝基礎等等。當將本發明之組 成物使用作為護髮產品時，可將其加工成頭髮生長刺激 劑、造型劑等等。當將本發明之組成物使用作為護體產品518233 V. Description of the invention (11) ^^ Powder polymers such as methylamine powder and methyl hydroxy starch, substances such as acetyl cellulose, ethyl cellulose, hydroxy hydroxypropyl cellulose J and ethyl acetate Cellulose, Cellulose Sulfate, Hydroxypropyl Cellulose, Sodium, Hydroxyl, Sodium Hydroxyl, and Crystalline Cellulose; Alginic polymers such as alginic acid = I-based fibers alginate; vinyl polymers such as polyethylene Alcohol, = acetic acid diol polyvinyl fluorenyl ether, polyvinylpyrrolid sea bream, ethylene: ^, vinegar, vinyl acetate copolymer and carboxyvinyl polymer; acrylic = / such as sodium polyacrylate, Polyethyl acrylate, polyalkanolamine acrylate, ^ = alkyl acrylates / dimethyamine methacrylate copolymer, poly (2-propylpropylamido-2-methylpropionite flavonic acid) And polyacrylic acid based oxygen reagents such as ultraviolet light absorbers, chelating agents, vitamins, anti-inflammatory agents, preservatives, plant extracts and cooling agents; and Θ chinols such as ethyl alcohol and isopropyl alcohol Propanol. The composition of the present invention can be applied to skin, hair, and the like. The product can take various forms, including aqueous system, dissolution system: emulsion system, oily liquid system, gel system, ointment system, aerosol, water and oil two-layer system, and water / oil / powder three-layer system. Although the composition of the present invention is particularly useful as a cosmetic product, it may also be useful as a pharmaceutical product, a pharmaceutical product, or the like. When the composition of the present invention is used as a basic chain product, skin care oils (lotions), lotions, creams, gels, and the like can be used. When the composition is used as a modified cosmetic, it can be processed into: using 'two eyelashes, makeup foundation, and the like. When the composition of the present invention is used as a hair care product, it can be processed into a hair growth stimulant, a styling agent, and the like. When the composition of the present invention is used as a body care product

518233518233

ΐ膏Γΐ其力卜曬黑劑、曰曬後保護產品、護 t寺4 w將本發明之組成物使用作為藥品或類鏟σ 柃’可將其加工成各種軟膏等等。然❿，本發明之绀： 並不限於此等劑量形式或產品形式。 、，且成物 將實施例作更詳細說明，但應明瞭不應 將本發明解釋為受限於此。 “ 參考實施例1 琥珀葡聚糖之ξ造實施你丨ΐ cream ΐ ΐ its tanning agent, after-sun protection products, protect the temple 4 w Use the composition of the present invention as a medicine or shovel σ 柃 'can be processed into various ointments and so on. However, the invention is not limited to these dosage forms or product forms. Examples will be described in more detail, but it should be understood that the present invention should not be construed as being limited thereto. "Reference Example 1 Implementation of succindextran you 丨

根據說明於JP-B-6-74283 (此處所使用之術語「Jp — B」 係指「經審查的日本專利公告」）中之方法製造琥珀葡^ 糖。換言之，在具有即將明確說明於後之組成物之培養基 中使用根癌土壤桿菌I - 7 3 6菌種進行發酵。 ° 土The amber glucose is manufactured according to the method described in JP-B-6-74283 (the term "Jp — B" as used herein means "Examined Japanese Patent Publication"). In other words, Agrobacterium tumefaciens I-7 36 is used for fermentation in a medium having a composition to be described later. ° soil

更明確έ之’將培養基接種根癌土壤桿菌I — γ 3 6菌種， 然後將其在2 0公升（1 5公升有效）B i ο 1 a f f i t eTM容器中在2 8 °(：下，邊利用1^31:〇1^攪拌器在400 rpm之攪拌下，邊在 8 2 5公升/小時之速率下通氣而進行培養。於在授拌下進 行培養9 0小時後（即使蔗糖完全或實質上完全消耗所需之 時間），製得以所使用蔗糖計為6 6重量百分比之雜多畴。 當利用Brookf i e 1 d LTVTM黏度計使用4號圓柱迴轉桿在3〇 rpm下測量時，發酵液體具有680 0帕斯卡（pa)/秒之黏 度0 於將如前所述之發酵液體在9 〇 °C下加熱3分鐘後，以下 列方式自其回收得2公斤之破珀葡聚糖。換言之，於加熱 後，將230 0毫升之異丙醇加至發酵液體中。其次再加入To be clearer, inoculate the medium with Agrobacterium tumefaciens I — γ 36 strain, and then place it in a 20 liter (15 liter effective) B i ο 1 affit eTM container at 2 8 ° (: side, side Cultivate with a 1 ^ 31: 〇1 ^ stirrer at 400 rpm while aerating at a rate of 8 25 liters / hour. After 90 hours of incubation under incubation (even if the sucrose is completely or substantially Time required for complete consumption) to produce a heteropoly domain with a sucrose content of 66 weight percent. When measured with a Brookfie 1 d LTVTM viscometer using a No. 4 cylindrical rotary rod at 30 rpm, the fermentation liquid Having a viscosity of 6800 Pascals (pa) / second 0 After heating the fermentation liquid as described above at 90 ° C for 3 minutes, 2 kg of dehydroglucosan was recovered from it in the following manner. In other words, After heating, add 2300 ml of isopropanol to the fermentation liquid. Then add

88116157.ptd 第15頁 )1823388116157.ptd p. 15) 18233

518233 五、發明說明（14) X :由5位以下的參試者評估為良好。 長期安定性 在0 °C、室温、3 7 °C及5 0 °C下進行溫度試驗，並根據以 下標準評估結果。 ◎:在每個測試溫度下皆未觀察到異常（分離等等）。 〇：於在50 °C下儲存1個月後觀察到輕微異常（分離等 等）。 △:於在37 °C下儲存1個月後觀察到輕微異常（分離等 等）。 X :於在0 °C或室溫下儲存1個月後觀察到異常（分離等 等）。 實施例1至7 乳T · 表1概述實施例1至7之乳膏之成份及組成物，及其使用 時感覺和長期安定性的評估結果。518233 V. Description of the invention (14) X: It is evaluated as good by 5 or less participants. Long-term stability Perform temperature tests at 0 ° C, room temperature, 37 ° C, and 50 ° C, and evaluate the results according to the following criteria. :: No abnormality (separation, etc.) was observed at each test temperature. 〇: A slight abnormality (isolation, etc.) was observed after 1 month of storage at 50 ° C. △: A slight abnormality (isolation, etc.) was observed after 1 month of storage at 37 ° C. X: Abnormalities (isolation, etc.) were observed after storage at 0 ° C or room temperature for 1 month. Examples 1 to 7 Milk T · Table 1 summarizes the ingredients and compositions of the creams of Examples 1 to 7, and the results of evaluation of the feeling and long-term stability during use.

88116157.ptd 第17頁 518233 五、發明說明（15) 表1 例1 例2 例3 例4 例5 例6 例7 成份 iwt.°/〇) A.遇水膨脹黏土礦物相 去離子水 30.0 30.0 30.0 30.0 30.0 30.0 30.0 二丙二醇 5.0 5.0 5.0 5.0 5.0 5.0 5.0 皂土 (SUMECTON™ 3.0 3.0 3.0 3.0 3.0 3.0 3.0 § A，Kunimine Kogyo 製造） B.琥珀葡聚糖相 去離子水 56.892 56.8^ 56.7 54.9 48.9 43.9 39.9 乙醇 5.0 5.0 3.0 5.0 5.0 5:0 5.0 對羥基苯甲酸甲酯 0.1 0.1 0.1 0.1 0.1 0.1 0.1 琥珀葡聚糖 0.00« 0.02 0.2 2.0 8.0 13.0 17.0 評估結果 塗布時的可擴展性 〇 〇 〇 〇 〇 〇 〇 使用後的滋潤感 〇 〇 〇 〇 〇 〇 〇 使用後的淸爽感 ◎ ◎ ◎ ◎ ◎ 〇 ◎ 長期安定性 Δ 〇 ◎ ◎ ◎ ◎ Δ 1B1 88116157.ptd 第18頁 518233 51823388116157.ptd Page 17 518233 V. Description of the invention (15) Table 1 Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Example 7 Ingredient iwt. ° / 〇) A. Water-swelling clay mineral phase deionized water 30.0 30.0 30.0 30.0 30.0 30.0 30.0 Dipropylene glycol 5.0 5.0 5.0 5.0 5.0 5.0 5.0 Bentonite (SUMECTON ™ 3.0 3.0 3.0 3.0 3.0 3.0 3.0 § A, manufactured by Kunimine Kogyo) B. Succindextran phase deionized water 56.892 56.8 ^ 56.7 54.9 48.9 43.9 39.9 Ethanol 5.0 5.0 3.0 5.0 5.0 5: 0 5.0 Methyl parahydroxybenzoate 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 Succindextran 0.00 «0.02 0.2 2.0 8.0 13.0 17.0 Evaluation results Scalability during application 〇〇〇〇〇〇〇〇 Moisturizing feeling after use 〇〇〇〇〇〇〇 After the use of refreshing feeling ◎ ◎ ◎ ◎ ◎ ◎ Long-term stability Δ ○ ◎ ◎ ◎ Δ 1B1 88116157.ptd Page 18 518233 518233

五、發明說明06) f造方洼 使遇水細脹黏土擴物相A在均勻分散機中均勻地膨脹。 然後將已經由在另一瓶中攪拌而溶解之琥轴葡聚糠相 入，並經由攪拌而均勻混合所得混合物，因此產生乳膏。 如由表1之結果所清楚顯示，經由使用低於〇 · 〇丨重量百 分比之琥珀葡聚糖所製得之乳膏並不受歡迎，由於其產生 良好的使用時感覺，但顯現不良的長期安定性。當琥轴葡 聚糖含量超過0· 1重量百分比時，所製得之乳膏為凝膠形 悲’且顯現非常優異的長期安定性。當琥珀葡聚糖含量超 過1 5 · 0重量百分比時，所製得之乳膏並不受歡迎，由於其 在使用時會賦予膠黏感，且於使用後無法產生任何' : 感覺。 如由表1所示之結果所證實，在本發明之組成物中的琥 ί白葡聚糖含量以自〇 · 〇 1至1 5 · 〇重量百分比較佳，自〇 · J至 1 0 · 0重量百分比又較佳。 實施例8至1 3及比較實施例1 增白乳膏： 表2概述實施例8至13及比較實施例1之增白乳膏之成份 及組成物，及其使用時感覺和長期安定性的評估結果。V. Description of the invention 06) f Make a square depression Expand the phase A of the clay which is finely swelled with water in a uniform disperser. Then, succinica cocoa bran, which had been dissolved by stirring in another bottle, was added, and the resulting mixture was uniformly mixed by stirring, thereby producing a cream. As is clear from the results in Table 1, creams made by using less than 0.00% by weight of succindextran are unpopular because they produce a good feel during use but show poor long-term appearance. Stability. When the content of saccharin glucan exceeds 0.1% by weight, the resulting cream is gel-shaped and exhibits very excellent long-term stability. When the content of succindextran exceeds 15.0% by weight, the resulting cream is unpopular, as it imparts a sticky feel during use and cannot produce any ': feel after use. As confirmed by the results shown in Table 1, the content of selenium glucan in the composition of the present invention is preferably from 0.001 to 15% by weight, and from 〇J to 1 · 0. 0 weight percent is more preferred. Examples 8 to 13 and Comparative Example 1 Whitening cream: Table 2 summarizes the ingredients and composition of the whitening creams of Examples 8 to 13 and Comparative Example 1, and their feeling and long-term stability when used. evaluation result.

88116157.ptd 518233 五、發明說明（17) 表288116157.ptd 518233 V. Description of the invention (17) Table 2

例8 例9 例10 例11 例12 例13 比較 例1 成份(wt.%) A.遇水膨脹黏土礦物相 去離子水 50.0 50.0 50.0 50.0 50.0 50.0 50.0 甘油 5.0 5.0 5.0 5.0 5.0 5.0 5.0 微晶高嶺石(kunipia™ 0.008 0.02 2,0 6.0 10.0 13.0 6.0 G-4，Kunimine Kogyo 製 造） 二葡萄糖fk壞血酸酯 2,0 2.0 2.0 2.0 2.0 2.0 2.0 B.琥珀葡聚糖相 去離子水 38.892 38.88 36.9 32.9 28.9 25.9 32.9 異丙醇 3.0 3.0 3.0 3.0 3.0 3.0 3.0 對羥基苯甲酸甲酯 0.1 0.1 0.1 0.1 0.1 0.1 0.1 琥珀葡聚糖 1.0 1.0 1.0 1.0 1.0 1.0 Ί 羧乙烯基聚合物 - - - - - 1.0 評佶結果 塗布時的可擴展性 〇 〇 〇 〇 〇 〇 〇 使用後的滋潤感 〇 〇 〇 〇 〇 〇 〇 使用後的淸爽感 ◎ ◎ ◎ ◎ ◎ 〇 〇 長期安定性 Δ 〇 ◎ ◎ ◎ ◎ XExample 8 Example 9 Example 10 Example 11 Example 12 Example 13 Comparative Example 1 Composition (wt.%) A. Water-swelling clay mineral phase deionized water 50.0 50.0 50.0 50.0 50.0 50.0 50.0 Glycerin 5.0 5.0 5.0 5.0 5.0 5.0 5.0 Microcrystalline kaolinite (kunipia ™ 0.008 0.02 2,0 6.0 10.0 13.0 6.0 G-4, manufactured by Kunimine Kogyo) Diglucose fk ascorbate 2,0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 B. Succindextran phase deionized water 38.892 38.88 36.9 32.9 28.9 25.9 32.9 Isopropanol 3.0 3.0 3.0 3.0 3.0 3.0 3.0 Methyl parahydroxybenzoate 0.1 0.1 0.1 0.1 0.1 0.1 0.1 Succindextran 1.0 1.0 1.0 1.0 1.0 1.0 Ί Carboxyvinyl polymer-----1.0 Evaluation result Scalability at the time of application. Moisturizing feeling after use. 0.00000 Cool feeling after use. ◎ ◎ ◎ ◎ ◎ Long-term stability Δ ○ ◎ ◎ ◎ X

88116157.ptd 第20頁 518233 五、發明說明（18) 然在拌均機中均勻地^ 膏。由料而均勻混合所得混合物，因此產生增白乳 所i::ΐ ? ί聚合物使用作為琥珀葡聚糖之替代品時， ，仔…的長期安定性差(實施例u，比較實施例 八:ί2禹''結果所清楚顯示 '經由使用低於〇.01重量百 由於其顯現不良的長m”增白乳貧並不受歡迎’ 超過1 5 0舌旦 長』女疋性。*遇水膨脹黏土礦物含量 之增白乳；分比時，將變得报難製造具有本發明特性 水β If 2 2+所&不之結果所證貫，在本發明之組成物中的遇 0 1 ^ 0 0 ^ ^ 1 0 · 0 1 ^ 1 5 · 〇 t * ^ ^ i u · 1至1 ο · ο重量百分比又較佳。 貫施例較實施例2 精油： 成i3概Λ實施例14至20及比較實施例2之精油之成份及組 成物，及其使用時感覺和長期安定性的評估結果。88116157.ptd Page 20 518233 V. Description of the invention (18) Of course, paste evenly in a mixer. The resulting mixture is uniformly mixed from the raw materials, so that the whitening milk i :: ΐ? Ί polymer is used as a substitute for succindextran, and the long-term stability of the baby is poor (Example u, Comparative Example Eight: "2 Yu" results clearly show that 'by using less than 0.01 weight percent because of its poor appearance m "whitening milk poor is unpopular' more than 1 5 0 tongues long" son-in-law sex. * Meeting water Whitening milk with expanded clay mineral content; when it is divided, it will become difficult to produce water with the characteristics of the invention β If 2 2+ and & the result is not borne out, the occurrence of 0 1 in the composition of the invention ^ 0 0 ^ ^ 1 0 · 0 1 ^ 1 5 · 〇 t * ^ ^ iu · 1 to 1 ο · ο The weight percentage is better. The embodiment is better than the essential oil in Example 2: i3 is roughly Λ Examples 14 to 20 and Comparative Example 2 The results of the evaluation of the ingredients and compositions of the essential oils, and the feeling and long-term stability during use.

88116157.ptd 第21頁 518233 五、發明說明（19) 表3 例14 Μ 15 例16 例17 例18 例ί9 例20 比較 例2 βΚ,ΊΖΓΙ Wt.%) A.遇水膨脹黏土礦物相 去離子水 15.0 15.0 15.0 15 〇 15.0 15.0 15.0 15.0 海藻糖 1.0 1.0 1.0 1 0 1.0 1.0 1.0 1.0 鹽酸精胺酸 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 皂土 (SUMECTON™ 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 SA ’ Kunimine Kogyo 製造） B.琥珀葡聚糖相 去離子水 67.57 69.5 69.25 67.65 41.65 32.§5 27.65 41.65 即享 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 對羥基苯甲酸甲酯 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0,1 琥珀葡聚糖 0.2 0.2 0.2 0.2 0.2 0.2 0.2 動 黃酸樹膠 - ** - - - 0.2 C.油性成份相 1，3-丁二醇 5.0 5.0 5,0 5.0 5.0 5.0 5.0 5.0 POE(60莫耳)硬化蓖麻油 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 角鯊烷 0.08 0.15 0.4 2.0 28.0 37.0 42.0 28.0 生育酚乙酸酯 0.05 0.05 0.05 0.05 0.05 0.05 0.05 0.05 W估結果 塗布時的可擴展性 〇 ◎ ◎ ◎ ◎ ◎ ◎ Δ 使用後的滋潤感 〇 〇 ◎ ◎ ◎ ◎ ◎ Δ 使用後的淸爽感 ◎ ◎ ◎ ◎ ◎ 〇 Δ X 長期安定性 ◎ ◎ ◎ ◎ ◎ ◎ ◎ 〇88116157.ptd Page 21 518233 V. Description of the invention (19) Table 3 Example 14 Μ 15 Example 16 Example 17 Example 18 Example ί 9 Example 20 Comparative Example 2 βΚ, ΊZΓΓ Wt.%) A. Water-swelling clay mineral phase deionized water 15.0 15.0 15.0 15 〇15.0 15.0 15.0 15.0 Trehalose 1.0 1.0 1.0 1 1 1.0 1.0 1.0 1.0 1.0 Arginine hydrochloride 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 Bentonite (SUMECTON ™ 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 SA '' made by Kunimine Kogyo ) B. Succindextran phase deionized water 67.57 69.5 69.25 67.65 41.65 32.§5 27.65 41.65 Enjoy 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 Methyl parahydroxybenzoate 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0,1 Sugar 0.2 0.2 0.2 0.2 0.2 0.2 0.2 Flavum gum-**---0.2 C. Oily component phase 1,3-butanediol 5.0 5.0 5,0 5.0 5.0 5.0 5.0 5.0 POE (60 mol) hardened castor oil 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 Squalane 0.08 0.15 0.4 2.0 28.0 37.0 42.0 28.0 Tocopheryl acetate 0.05 0.05 0.05 0.05 0.05 0.05 0.05 0.05 Scalability billion ◎ after the ◎ ◎ ◎ ◎ ◎ Δ using moist feeling billion billion ◎ ◎ ◎ ◎ ◎ Δ use Cheongdam cool feeling ◎ ◎ ◎ ◎ ◎ billion Δ X long-term stability ◎ ◎ ◎ ◎ ◎ ◎ ◎ billion

1IR11 88116157.ptd 第22頁 518233 五、發明說明（20) ' -----— 、使遇水膨脹黏土礦物相A在均勻分散機中均勻地膨脹。 然後將已經由在另一瓶中攪拌而溶解之琥珀葡聚糖相$加 入，並經由攪拌而均勻混合所得混合物。此外，將已經 使用均相混合機在另一瓶中製備得之油性成份相c加入， 並經由攪拌而均勻混合所得混合物，因此產生精油。 當將黃酸樹膠使用作為琥珀葡聚糖之替代品時，所製得 之精油的使用時感覺差，尤其係使用後的清爽感差（實施于 例18，比較實施例2)。 〜 、也 如表3中之結果所清楚顯示，本發明之組成物之塗布時 的可擴展性及使用後的滋潤感經由加入角鯊烷（即油性^ 份）而獲得改良。然而，當角鯊烷含量低於〇·丨重量百分比 時’組成物之塗布時的可擴展性及使用後的滋潤感並無法 獲得充分的改良。另一方面，角鯊烷含量超過4〇· 〇重&百 分比並不受歡迎，由於在此情況中使用後的滋潤感會失 去，且使用時的感覺會變差。 如由表3所示之結果所證貫’在本發明之組成物中的油 性成份含量以自0 · 1至4 0 · 0重量百分比較佳，自〇. 3至3 〇 〇 重量百分比又較佳。 實施例2 1黾2 5 化粧基礎： 表4概述貫施例21至2 5之化粧基礎之成份及組成物，及 其使用時感覺和長期安定性的評估結果。1IR11 88116157.ptd Page 22 518233 V. Description of the invention (20) '------, the water-swellable clay mineral phase A is uniformly expanded in a uniform disperser. The succindextran phase $, which had been dissolved by stirring in another bottle, was then added, and the resulting mixture was uniformly mixed by stirring. In addition, the oily component phase c, which has been prepared in another bottle using a homomixer, is added, and the resulting mixture is uniformly mixed by stirring, thereby producing an essential oil. When xanthan gum is used as a substitute for succindextran, the essential oil produced has a poor feeling during use, especially the refreshing feeling after use (implemented in Example 18, Comparative Example 2). As is clear from the results in Table 3, the expandability of the composition of the present invention during application and the moisturizing feeling after use are improved by adding squalane (ie, oily parts). However, when the squalane content is less than 0.1% by weight, the expandability of the composition and the moisturizing feeling after use cannot be sufficiently improved. On the other hand, a squalane content exceeding 40.0% by weight & is not welcome, because in this case the moisturizing feeling is lost after use and the feeling during use becomes worse. As evidenced by the results shown in Table 3, the content of the oily component in the composition of the present invention is preferably from 0.1 to 40% by weight, and from 0.3 to 300% by weight. good. Example 2 1 黾 2 5 Makeup Foundation: Table 4 summarizes the ingredients and compositions of the makeup foundations of Examples 21 to 25, and the evaluation results of feeling and long-term stability during use.

88116157.ptd 第23頁 518233 五、發明說明（21) 表4 例21 例22 例23 例24 例25 成份iwt.%) A.遇水膨脹黏土礦物相 去離子水 15.0 15.0 15.0 15.0 15.0 木糖醇 1.0 1.0 1.0 1.0 1.0 虎耳草萃取物 1.0 1.0 1.0 1.0 1.0 皂土 (VEEGUM™ 2.0 2.0 2.0 2.0 2.0 S-6198，RT. Vanderbilt 製造） 檸檬酸 0.1 0.1 0.1 0.1 0.1 檸檬酸鈉 0.1 0.1 0.1 σ.ι 0.1 B.琥珀葡聚糖相 去離子水 57.16 57.15 57.06 56.16 54.16 乙醇 15.0 15.0 15.0 15.0 15.0 對羥基苯甲酸甲酯 0.1 0.1 0.1 0.1 0.1 琥珀葡聚糖 0.5 0.5 0.5 0.5 0.5 伸乙二胺四乙酸三鈉 0.02 0.02 0.02 0,02 0.02 C.油性成份相 POE(60莫耳)硬化蓖麻油 - 0.01 0.1 1.0 3.0 二甲基聚矽氧烷(6cs) 3.0 3.0 3.0 3.0 3.0 十甲基環戊矽氧烷 5.0 5.0 5.0 5.0 5.0 維生素A棕櫚酸酯 0.02 0.02 0.02 0.02 0.02 評估結果 塗布時的可擴展性 ◎ ◎ ◎ ◎ ◎ 使用後的滋潤感 ◎ ◎ ◎ ◎ ◎ 使用後的淸爽感 ◎ ◎ ◎ ◎ 〇 長期安定性 Δ 〇 ◎ ◎ ◎ «88116157.ptd Page 23 518233 V. Description of the invention (21) Table 4 Example 21 Example 22 Example 23 Example 24 Example 25 Ingredient iwt.%) A. Water-swelling clay mineral phase deionized water 15.0 15.0 15.0 15.0 15.0 Xylitol 1.0 1.0 1.0 1.0 1.0 Saxifraga extract 1.0 1.0 1.0 1.0 1.0 Bentonite (VEEGUM ™ 2.0 2.0 2.0 2.0 2.0 S-6198, manufactured by RT. Vanderbilt) Citric acid 0.1 0.1 0.1 0.1 0.1 Sodium citrate 0.1 0.1 0.1 σ.ι 0.1 B. Succindextran phase deionized water 57.16 57.15 57.06 56.16 54.16 Ethanol 15.0 15.0 15.0 15.0 15.0 Methyl parahydroxybenzoate 0.1 0.1 0.1 0.1 0.1 Succindextran 0.5 0.5 0.5 0.5 0.5 Trisodium ethylenediamine tetraacetate 0.02 0.02 0.02 0,02 0.02 C. Oily ingredient phase POE (60 mol) hardened castor oil-0.01 0.1 1.0 3.0 dimethyl polysiloxane (6cs) 3.0 3.0 3.0 3.0 3.0 decamethylcyclopentasiloxane 5.0 5.0 5.0 5.0 5.0 Vitamin A palmitate 0.02 0.02 0.02 0.02 0.02 Evaluation results Scalability during coating ◎ ◎ ◎ ◎ ◎ Moisturizing feeling after use ◎ ◎ ◎ ◎ ◎ Refreshing feeling after use ◎ ◎ ◎ billion of long-term stability Δ billion ◎ ◎ ◎ «

88116157.ptd 第24頁 518233 五、發明說明（22) 製造方法 使遇水膨脹黏土礦物相A在均勾分散機中均勻地膨脹。 然後將已經由在另一瓶中攪拌而溶解之琥珀葡聚糖相B加 入’並經由挽掉而均勻化合所得混合物。此外，將已經由 使用均相混合機在另一瓶中製備得之油性成份相c加入， 並經由攪拌而均勻混合所得混合物，因此產生化粧基礎。 如表4中之結果所清楚顯示，化粧基礎之長期安定性經 由在遇水膨脹黏土石廣物及琥珀葡聚糖之外使用二甲基聚石夕 氧烷（6 cs)及十甲基環戊矽氧烷（即油性成份）而務微退 化。然而，可經由再加入0 · 0 1重量百分比以上，尤其係〇 1重量百分比以上之表面活性劑，而得到具優異長期安定 性之化粧基礎。 實施例2 6爰2 Q 化粧基礎： 表5概述實施例2 1及實施例2 6至2 9之化粧基礎之成份及 組成物，及其使用時感覺和長期安定性的評估結果。88116157.ptd Page 24 518233 V. Description of the invention (22) Manufacturing method The water-swellable clay mineral phase A is uniformly expanded in a homogeneous disperser. Succindextran phase B, which has been dissolved by stirring in another bottle, is then added to 'and the resulting mixture is homogenized by removal. In addition, the oily component phase c, which has been prepared in another bottle using a homomixer, is added, and the resulting mixture is uniformly mixed by stirring, thereby creating a makeup base. As the results in Table 4 clearly show, the long-term stability of the makeup foundation is achieved through the use of dimethylpolyxoxane (6 cs) and decamethylcyclopentane in addition to water-swellable clay stones and succindextran. Siloxane (ie, oily ingredients) is slightly degraded. However, a cosmetic base having excellent long-term stability can be obtained by further adding a surfactant of 0.01% by weight or more, especially 0.01% by weight or more. Example 2 6 爰 2 Q Makeup Foundation: Table 5 summarizes the ingredients and compositions of the makeup foundations of Examples 21 and 2 to 6-9, and the evaluation results of feeling and long-term stability during use.

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第25頁 518233 五、發明說明（23) 表5 例21 例26 例27 例28 29 成份iwt.%) A.遇水膨脹黏土礦物相 去離子水 15.0 15.0 15.0 15.0 15.0 木糖醇 1.0 1.0 1.0 1.0 1.0 虎耳草萃取物 1.0 1.0 1.0 1.0 1.0 皂土 (VEEGUM™ 2.0 2.0 2.0 2.0 2.0 S-6198，RTf Vanderbilt 製造） 檸檬酸 0.1 0.1 0.1 0.1 0.1 檸檬酸鈉 0.1 0.1 0.1 0.1 0.1 B.琥珀葡聚糖相 去離子水 57.16 57.155 57.11 56.66 55.16 乙醇 15.0 15.0 15.0 15.0 15.0 對羥基苯甲酸甲酯 0.1 0.1 0.1 0.1 0.1 琥珀葡聚糖 0.5 0.5 0.5 0.5 0.5 · 伸乙二胺四乙酸三鈉 0.02 0.02 0.02 0.02 0,02 C.油性成份相 丙烯酸烷酯·甲基丙烯酸烷 酯共聚物(P EMULEN™ - 0.005 0.05 0.5 2.0 TR-2，BF Goodrich 製造） 二甲基聚矽氧烷(6cs) 3.0 3.0 3.0 3.0 3.0 十甲基環戊矽氧烷 5.0 5.0 5.0 5.0 5.0 維生素A棕櫚酸酯 0.02 0.02 0.02 0.02 0.02 評佔結果 塗布時的可擴展性 ◎ ◎ ◎ ◎ ◎ 使用後的滋潤感 ◎ ◎ ◎ ◎ ◎ 使用後的淸爽感 ◎ ◎ ◎ ◎ 〇 長期安定性 Δ 〇 ◎ ◎ ◎ ΦPage 25 518233 V. Description of the invention (23) Table 5 Example 21 Example 26 Example 27 Example 28 29 Ingredient iwt.%) A. Water-swelling clay mineral phase deionized water 15.0 15.0 15.0 15.0 15.0 Xylitol 1.0 1.0 1.0 1.0 1.0 Saxifraga extract 1.0 1.0 1.0 1.0 1.0 bentonite (VEEGUM ™ 2.0 2.0 2.0 2.0 2.0 S-6198, manufactured by RTf Vanderbilt) citric acid 0.1 0.1 0.1 0.1 0.1 sodium citrate 0.1 0.1 0.1 0.1 0.1 Ionic water 57.16 57.155 57.11 56.66 55.16 Ethanol 15.0 15.0 15.0 15.0 15.0 Methyl parahydroxybenzoate 0.1 0.1 0.1 0.1 0.1 Succindextran 0.5 0.5 0.5 0.5 0.5Triethylenediamine tetraacetic acid trisodium 0.02 0.02 0.02 0.02 0,02 C .Oil-based component alkyl acrylate / methacrylate copolymer (P EMULEN ™-0.005 0.05 0.5 2.0 TR-2, manufactured by BF Goodrich) Dimethicone (6cs) 3.0 3.0 3.0 3.0 3.0 Decamethyl Cyclopentasiloxane 5.0 5.0 5.0 5.0 5.0 Vitamin A palmitate 0.02 0.02 0.02 0.02 0.02 Evaluation results Scalability during coating ◎ ◎ ◎ ◎ Moisturizing feeling ◎ ◎ ◎ ◎ ◎ Refreshing feeling after use ◎ ◎ ◎ ◎ 〇 Long-term stability Δ 〇 ◎ ◎ ◎ Φ

88116157.ptd 第26頁 518233 五、發明說明（24) 製造方法 實施例2 6至2 9之化粧基礎係以如同實施例2 1至2 5之方式 製造。 如表5中之結果所清楚顯示，可經由在遇水膨脹黏土石廣 物、琥珀葡聚糖及油性成份之外使用0 · 0 0 5重量百分比以 上，尤其係0.05重量百分比以上之丙烯酸烷酯•甲基丙烯 酸烷酯共聚物，而得到產生優異的使用後滋潤感且具有高 長期安定性之化粧基礎。 實施例3 0 粉底： 表6顯示貫施例3 0之粉底之成份及組成物，及其使用時 感覺和長期安定性的評估結I。88116157.ptd Page 26 518233 V. Description of the invention (24) Manufacturing method The makeup bases of Examples 2 6 to 29 are manufactured in the same manner as in Examples 2 1 to 25. As the results in Table 5 clearly show, it is possible to use 0 · 0 0 5 weight percent or more, especially 0.05 weight percent or more of alkyl acrylate, in addition to water-swellable clay stones, succindextran and oily ingredients. Alkyl methacrylate copolymer to obtain a cosmetic foundation that produces excellent post-use moisturization and has high long-term stability. Example 30 Foundation: Table 6 shows the ingredients and composition of the foundation of Example 30, and the evaluation of feeling and long-term stability during use.

518233 五、發明說明（25) 表6 實施例30 (wt. %) 成份 A.遇水膨脹黏土礦物相 去離子水 25.0 赤蘚醇 1.0 聚乙二醇1000 3.0 鋰蒙脫石(LOPONITE™，Laporte Industries 製造) 3.0 乳酸 0.1 乳酸鈉 0.05 B.琥珀葡聚糖相 去離子水 24.55 乙醇 3.0 對羥基苯甲酸甲酯 0.1 苯氧乙醇 0.2 琥珀葡聚糖 0.4 C.油性成份相 POE(2〇莫耳)山箭基醚 0.5 澳洲堅果仁油 2.0 十甲基環戊矽氧烷 2.0 D.粉末相 去離子水 20.0 偏磷酸鈉 0.03 二氧化欽 4.0 雲母 10.0 氧化鐵(紅色） 0.02 氧化鐵(黃色） 0.04 氧化鐵(黑色） 0.01 聚矽氧粉末 1.0 評估結果 塗布時的可擴展性 ◎ 使用後的滋潤感 ◎ 使用後的淸爽感 ◎ 長期安定性 ◎ 88116157.ptd 第28頁 518233 五、發明說明（26) 製造方法 使遇水膨脹黏土礦物相A在均勻分散機中 然後將已經由在另一瓶中攪拌而溶解之琥勻取地膨脹。 入，並經由攪拌而均勻混合所得混合物广 葡聚糖相B加 使用均相混合機在另一瓶中製備得：二匕：’將已經由 並經由攪拌而均勻混合所得混合物。 成伤相C加入， 均相混合機在另一瓶中製備得之：者，將已經由使用 拌而均勻混合所得混合物，目此產生粉底加人，並經由授 如由表6所不之結果所清楚 _ 使用時感覺及長期安定性優里“ I據本發明之粉底的 复2包例3 1 ’、 防曬劑： 表7顯示實施例3 1之防鼸令丨 睥汚與4旦如6 方麗劑之成份及組成物，及其使用 4感覺和長期安定性的評估結果。518233 V. Description of the invention (25) Table 6 Example 30 (wt.%) Ingredient A. Water-swelling clay mineral phase deionized water 25.0 Erythritol 1.0 Polyethylene glycol 1000 3.0 Lithium montmorillonite (LOPONITE ™, Laporte Industries (Manufacturing) 3.0 lactic acid 0.1 sodium lactate 0.05 B. succindextran phase deionized water 24.55 ethanol 3.0 methyl parahydroxybenzoate 0.1 phenoxyethanol 0.2 succindextran 0.4 C. oily component phase POE (20 mol) mountain arrow base Ether 0.5 Macadamia Kernel Oil 2.0 Decamethylcyclopentasiloxane 2.0 D. Powder phase deionized water 20.0 Sodium metaphosphate 0.03 Dioxin 4.0 Mica 10.0 Iron oxide (red) 0.02 Iron oxide (yellow) 0.04 Iron oxide (black) 0.01 Polysilicone powder 1.0 Evaluation results Scalability during coating ◎ Moisturizing feeling after use ◎ Refreshing feeling after use ◎ Long-term stability ◎ 88116157.ptd Page 28 518233 V. Description of the invention (26) Manufacturing method makes water contact The expanded clay mineral phase A was uniformly expanded in a homogeneous disperser and the turkey, which had been dissolved by stirring in another bottle, was uniformly expanded. The dextran phase B was added in a homogeneous mixer using a homomixer to prepare: dagger: 'The resulting mixture has been uniformly mixed with and by stirring. Add the wound phase C, and prepare it in another bottle with a homogeneous mixer: the mixture that has been homogeneously mixed by using the mixture to produce a foundation and add the results shown in Table 6 What is clear _ The feeling and long-term stability during use are excellent. “I The foundation of the present invention is 2 packs of Example 3 1 ′, sunscreen: Table 7 shows the anti-fouling order of Example 3 1 tainting and 4 deniers such as 6 squares The ingredients and composition of the cream, and the results of the 4 sensory and long-term stability evaluations.

88ll6l57.ptd 第29頁 518233 五、發明說明（27) 表7 實施例31 (wt. %) 成份 A.遇水膨脹黏土礦物相 去離子水 20.0 二丙二醇 3.0 微晶高嶺石(KUNIPIAW，Kunimine Kogyo 製造） 2.0 B.琥珀葡聚糖相 去離子水 2ΪΛ7 乙醇 10.0 對羥基苯甲酸甲酯 0.1 苯氧乙醇 0.2 琥珀葡聚糖 0.5 C.油性成份相 POE(30莫耳)硬脂酸酯 0.5 硬脂酸鈣 0.5 具高聚合度之甲基聚矽氧烷(2)-甲基聚矽氧烷溶液 2.0 (20%) 十甲基環戊矽氧烷 2.0 肉桂酸十甲氧酯 5.0 D.粉末相 去離子水 20.0 偏磷酸鈉 0.03 二氧化鈦 6.0 氧化鋅 5.0 氧化砂 1.0 評佶結果 塗布時的可擴展性 ◎ 使用後的滋潤感 ◎ 使用後的淸爽感 ◎ 長期安定性 ◎ «88ll6l57.ptd Page 29 518233 V. Description of the invention (27) Table 7 Example 31 (wt.%) Ingredient A. Water-swelling clay mineral phase deionized water 20.0 Dipropylene glycol 3.0 microcrystalline kaolinite (KUNIPIAW, manufactured by Kunimine Kogyo) 2.0 B. Succindextran phase deionized water 2ΪΛ7 Ethanol 10.0 Methyl parahydroxybenzoate 0.1 Phenoxyethanol 0.2 Succindextran 0.5 C. Oily component phase POE (30 moles) stearate 0.5 calcium stearate 0.5 Methylpolysiloxane (2) -methylpolysiloxane solution with high degree of polymerization 2.0 (20%) Decamethylcyclopentasiloxane 2.0 Decamyl cinnamate 5.0 D. Powder phase deionized water 20.0 Sodium metaphosphate 0.03 Titanium dioxide 6.0 Zinc oxide 5.0 Sand oxide 1.0 Evaluation results Scalability during coating ◎ Moisturizing feeling after use ◎ Refreshing feeling after use ◎ Long-term stability ◎ «

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五、發明說明（28) 製造方法 使遇水膨脹黏土礦物相A在均句分散機中均勻地膨脹。 然後將已經由在另-瓶中攪拌而溶解之 入’並經由攪拌而均句混合所得混合物 葡广加 使用均相混合機在另一瓶中製備得卜 、、二由 並經由授拌而均句混合所得混=成份相c加入’ 均相混合機在另一瓶中製備得之粉：者，將？由使用 拌：均句混合所得混合物’因此產生防曬劑。、由授 表7所示之結果顯示根據本發明 及長期安定性優異。 Μ月之防日麗劑的使用時感覺 實施 乳液： 感 ir二施二乳二\成份及組成物 及其使用時 518233 五、發明說明（29) 表8 實施例32 (wt. %) 成份 A.遇水膨脹黏土礦物相 去離子水 15.0 1，3-丁二醇 3.0 甘油 5.0 微晶高嶺石(KUNIPIA™，Kunimirte Kogyo 製造） 0.5 B.琥珀葡聚糖相 去離子水 61.45 乙醇 5.0 對羥基苯甲酸甲酯 ~ 0.1 苯氧乙醇 2.0 琥珀葡聚糖 0.2 黃酸樹膠 0.4 伸乙二胺四乙酸三鈉 0.05, C.油性成份相 丙烯酸烷酯•甲基丙烯酸烷酯共聚物 (PEMULEN™ TR，2，BF Goodrich 製造） 0.1 二甲基聚矽氧烷(6cs) 2.0 荷荷芭油 5.0 肉桂酸十甲氧酯 0.1 香料 0.05 評估結果 塗布時的可擴展性 ◎ 使用後的滋潤感 ◎ 使用後的淸爽感 ◎ 長期安定性 ◎ fV. Description of the invention (28) Manufacturing method The water-swelling clay mineral phase A is uniformly expanded in a homogeneous disperser. Then, the mixture that has been dissolved by stirring in another bottle is mixed and homogenized by stirring. The resulting mixture is prepared in a separate bottle using a homomixer. Sentence of mixing = ingredient phase c added 'Homogeneous mixer prepared in another bottle of powder: Who, will? The resulting mixture is mixed by the use of "mix: homogeneous" thus producing a sunscreen. The results shown in Table 7 show that the present invention is excellent in long-term stability. When using the anti-sun iris agent, the sensation of the lotion is as follows: sensation, second application, second emulsion, ingredients and composition and its use 518233 V. Description of the invention (29) Table 8 Example 32 (wt.%) Ingredient A Water-swellable clay mineral phase deionized water 15.0 1,3-butanediol 3.0 glycerol 5.0 microcrystalline kaolinite (KUNIPIA ™, manufactured by Kunimirte Kogyo) 0.5 B. succindextran phase deionized water 61.45 ethanol 5.0 paraben Esters ~ 0.1 Phenoxyethanol 2.0 Succindextran 0.2 Xanthan gum 0.4 Ethylene diamine tetraacetic acid trisodium 0.05, C. Oily component phase alkyl acrylate • alkyl methacrylate copolymer (PEMULEN ™ TR, 2, BF Goodrich) 0.1 dimethyl polysiloxane (6cs) 2.0 Jojoba oil 5.0 Decamethoxycinnamate 0.1 Fragrance 0.05 Evaluation results Scalability during application ◎ Moisturizing feeling after use ◎ Refreshing feeling after use ◎ Long-term stability ◎ f

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使遇水膨脹黏土礦物相八在均勻分 然後將已經由在另—瓶中授拌而溶解之换均句地膨脹。 入，並經由攪拌而均勻混合所得混人，b珀葡聚糖相B加 使用均相混合機在另一瓶中製備：：性:匕外’將已經^ 句所得混合物，因此產生乳液。 :s示之結果清楚地顯不，根據本發明之乳液的使 、感覺及長期安定性優異。本發明提供一種使用時可』 生新穎的感覺，可滿足消費者多樣化的需求且長期安定七 優異之尤其有用作為化粧品之外用組成物。 雖然本發明已經詳細說明並經參照其特定具體例，但熟 悉技藝人士當明瞭可不脫離其精神及範圍而對其中内容作 各種變化及修改。The water-swelling clay mineral phase is evenly divided, and then it has been expanded by dissolving in a separate bottle. Into the mixture, and uniformly mix the obtained mixed body by stirring, and b-glucan phase B was added in another bottle using a homogeneous mixer: the: the property: the outside of the mixture will be sentenced, so an emulsion is produced. The results shown by: s clearly show that the emulsion according to the present invention is excellent in stability, feel and long-term stability. The present invention provides a novel feeling when used, which can meet the diversified needs of consumers and has long-term stability. It is particularly useful as a composition for external use of cosmetics. Although the present invention has been described in detail and with reference to specific specific examples thereof, those skilled in the art will understand that various changes and modifications can be made thereto without departing from the spirit and scope thereof.

本申請案係以1 998年9月21曰提出申請之曰本專利申請 案No· Hei.-10-284784及1999年8月4日提出申請之No. Hei· -11—221118為基礎，將其併入本文為參考資料。This application is based on the patent application No. Hei.-10-284784, filed on September 21, 998, and No. Hei · -11-221118, filed on August 4, 1999. It is incorporated herein by reference.

^8116157.ptd 第33頁^ 8116157.ptd p. 33

Claims (1)

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