TW450806B - Insect repellent emulsions - Google Patents

Abstract

An insect repellent emulsion composition comprising: an insect repelling effective amount of N,N-diethyl-m-toluamide; water; 0.1 to 5 percent by weight of a film-forming polymer selected from the group consisting of copolymers of octadecene and maleic anhydride, copolymers of 1-triacontane and vinyl pyrrolidone, acrylates/octylacrylamide copolymer, acrylates/PVP copolymer, acrylates/acrylamide copolymer, acrylates/VA copolymer, ethylene/maleic anhydride copolymer, polyisobutene, polyvinyl alcohol, PVP/eicosane copolymer, starch/acrylates/acrylamide copolymer, hexanedioic acid polymers and mixtures of any two or more thereof; 0.01 to 5 percent by weight of an emulsifier-emulsion stabilizer selected from the group consisting of acrylates/C10-30 alkyl acrylate crosspolymer, carbomer, methyl vinyl ether/maleic anhydride copolymer, a salt of triethanolamine and stearic acid, and mixtures of any two or more thereof; and, optionally, from 0.1 to 10 percent by weight of an emulsifying agent selected from the group consisting of sorbitan stearate, stearic acid, sorbitan oleate, cetyl alcohol, glyceryl oleates, glyceryl stearatesx, sorbitan sesquioleate, DEA-cetyl phosphate, oleth-20, PEG-8 distearate, PEG-8 oleate, PEG-2 stearate, polysorbate 20, polysorbate 60, polysorbate 80, propylene glycol stearate, sodium laureth sulfate and mixtures of any two or more thereof.

Description

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經济部中央樣準局貝工消f合作社印装 Λ.#'委員明示，本裳齡正後是否變更原實贺内溶 4 5 〇 8 0 $第86117553號專利申請案 中文說明書修正頁(88年10月） 五、發明説明（1 ) 發明介紹 本發明係有關於含驅昆蟲藥DEET的液體調配物，特別 是其乳劑調配物* 人們長久以來使用過各種不同化學藥劑來減少惱人昆蟲（ 如蚊子、蒼堪、壁益、黃蜂和蜜蜂）的攻擊〇目前最廣泛使 用的驅昆蟲藥為Ν,Ν-二乙基-間甲苯醯胺，常被稱為 ”DEET·'。DEET為油性、有點吸濕性、光敏感性的油狀物 ，對其它不溶水的物質具有非常高的溶解力。由於其不易 乳化的缺點，使用時常製為濃縮型式或配成喷霧或稀釋溶 液，或固體或半固體型，如條型。為驅逐昆蟲，人們使用 DEET或含高達约l〇〇%DEET的調配物在衣服及裸露的皮 膚上。 然而’人們通常較喜歡水性物質在皮膚上的感覺β在化 妝品和醫學界中’已發現與水中油乳劑結合的油性物質更 討人喜歡。由於不溶解物質小滴完全被水包圍，使用時皮 膚的感覺就如同水性物質一樣。乳劑也比溶液喷劑和條型 勝狀物更易於均勻使用於皮膚上。然而，DEET通常無法 製成具有商業上所需安定性的乳劑，且要使用者在使用產 品前將分開之物相加以混合是相當不受歡迎的。 發明概要 本發明包括含有效量的Ν，Ν·二乙基，間甲苯醯胺、水、 成膜聚合物和乳化劑·乳劑安定物之油中水驅昆蟲乳劑。 此乳劑具商用可接受的儲存安定性和使用在皮膚時令人 喜愛的感覺。 1 :* ^^1 ^ϋ— 1^1 ^^^1 ·ί -I ί: : (請先Μ讀背面之注意事項再本頁) 訂 -4- ;4S0806 | A7 ； B7 五、發明説明（2 ) 發明詳述 在本申請案中，除非上下文清楚地顯示，否則所有提及 的"百分比"皆爲重量百分比。在此許多調配物成份（表面作 用劑，乳劑安定劑，成膜劑等）的名稱係出自J.A.溫尼格（J. A. Wenninger)等人所编之CTFA美容成份手册（CTFA Cosmetic Ingredient Handbook)，第二版，美容、化妝及香料協 會公司（The Cosmetic，Toiletry and Fragrance Association, Inc.)， 華盛頓，D.C.，1992年。 商用提供的DEET爲至少含約95%DEET的技街濃縮型。 其餘的5 %或少於5 %的部份包含水份和間-甲苯甲亟以外的 異構物（其它異構體也被認爲有一些驅昆蟲效力），及少量製 造程序中所使用人造物之雜質《爲單純起見，在此提到 DEET濃縮時應忽略其它成份："10%DEET"表示一種含 10%商用技術濃缩物。 本發明乳劑包含DEET(約5到約25百分比），連同水、成 膜聚合物和乳化劑乳化安定物。在某些實例中，補充乳化 劑可當做調配物成份》 經濟部中央標準局員工消費合作社印製 合適的補充乳化劑包括（但不限於）表面作用劑硬脂酸梨 -糖醇針Sg、硬脂酸、油酸山梨糖醇犴酯、鯨蠟醇、油酸甘油 酯、硬脂酸甘油酯、倍半油酸Oh梨糖醇酐酯、磷酸DEA-鯨 蠟酯、油醇醚-20(01eth-20)、PEG-8二硬脂酸酯、PEG-8油酸酯、PEG-2硬脂酸酯、聚山梨酸酯20、聚山梨酸酯 60、聚山梨酸酯80、硬脂酸丙二酯、月桂醇瞇硫酸鈉鹽 (sodium laureth sulfate)、倍半油酸山梨糖醇gfg旨及許 _____-5j____ 本紙張尺度適用中國國家標準（CNS [a4規格（2丨OX297公釐) ~ 450806 Α7 Β7 五、發明説明（3 ) 多此技藝中已知其他的作用劑。大體上（請記得此陳述中有 許多的例外），水中油乳劑的製備係利用親水親油平衡値 ("HLB")約8到約18的乳化劑。也可利用乳化劑的組合物， 而且經常發現比單一乳化劑能產生更佳的乳化安定性。當 使用组合物時，所有個別的HLB値可能不全在上述的範圍 裡’但總HLB値通常會在此範園中。大趙上，當乳化劑成 份出現時，其量約爲調配物的〇. 1 %到約1 〇%。 加入成膜聚合物是爲在皮膚使用時提供連續膜與調配物 之抗水性》抗水性可協助獲得驅昆蟲藥作用之延長β這對 參予水上活動的使用者來説特別有需要，如釣魚：滑水、 游泳或可能會接觸水的活動，或參加劇烈運動或粗重工作 而大量流汗者。實用的成膜劑包括：十八晞和順丁烯二酸 酐的共聚物；1-三十烷和乙缔基吡咯烷輞的共聚物；丙烯 酸酯/辛基丙烯醯胺共聚物；丙烯酸酯/PVP共聚物；丙 烯酸酯/丙烯醯胺共聚物；丙烯酸酯/VA共聚物；乙烯/ 順丁烯二酸犴共聚物、聚異丁烯；聚乙烯醇；PVP/二十 烷共聚物；澱粉/丙烯酸酯/丙烯醯胺共聚物；和己二酸 的聚合物。遑些成分通常佔調配物總量約〇. 1 %到約5% ?' 經濟部中央揉準局負工消費合作社印家 - 調配物中也需要乳化劑-乳液安定物，如丙烯酸酯/ C10-30烷基丙烯酸酯交鏈聚合物，聚羧乙烯製劑，甲基乙烯基 醚/順丁烯二酸酐共聚物，或硬脂酸之三乙醇胺鹽。合適 的市售丙烯酸酯/C10-3 0烷基丙烯酸酯交鏈聚合物有俄亥 俄州阿課隆之B.F.葛德里奇化學藥品公司（B.F. Goodrich Chemicals, Akron, Ohio)所提供的商品，名爲匹木蓮 ______-6·_ i紙張尺度適用中ΐ國家標準（CNS ) A4規格（210X297公釐） 4^0806 經濟部中央標準局負工消费合作社印衆 A7 B7 五、發明説明（4 ) (PEMULEN®) TR-1 和 TR-2、或卡爾玻波（CARBOPOL®)。典 型調配物中乳化劑-乳液安定劑的濃縮度爲約0.01 %到約5% 。在某些調配物中發現乳化安定劑匹木蓮TR-2的濃縮不應 超過約0.8%，以避免因黏度增加而影響乳劑的製備和處理。 其它的非必需成份，常包含於皮膚保養品中以增進使用 物質感、調理乾燥皮膚及/或防止微生物汙染調配物。包 括軟化劑、芬香劑、防腐劑、維化命' 濕潤劑、皮膚調理 劑、抗氧化劑及其它。除必需成份成份之外，上述其中任 一物質皆可視需要加入。 防曬成分也是調配物中實用可選擇的成份，尤真當使用 者同時需要保護對抗過度紫外線暴露時〇由於防曬活性藥 物的選擇通常被限制在官方認可的成份中，因此熟知此技 藝者皆知那些爲可接受的混合物。在美國，目前有：胺基 苯甲酸；對甲氧肉桂乙氧乙酯（cinoxate);二乙醇胺對甲 氧基肉桂酸酯；三油酸二掊醯酯；二氧苯酮；4-[二（羥丙基 )]胺基苯甲酸乙酯；2-氰基-3,3-二苯基丙烯酸2 -乙己酯； 對甲氧基肉桂酸乙基己酯；水揚酸2-乙基己酯；胺基苯甲 酸甘油酯：水揚酸三甲環己酯；含二羥基丙酮之2-羥-1.、· -審二明；胺茴酸薄荷腦基酯；氧苯酮；帕第梅特A (Padimate A);帕第梅特〇·; 苯基苯并咪唑_5_磺酸；紅 石堪’硫異本明（sulisobenzone)和三乙醇胺水楊酸黯》其 他活性防暖成分’如愛佛苯g^(av〇benzone)，二氧化欽和 苯基苯幷咪嗅磺酸，在許多國家被核准使用，也可加入本 發明驅昆蟲調配物。 本紙張尺度通用中國國家梯隼（CNS } A4規格（210X297公爱） (請先閲讀背面之注意事項再填寫本頁) vm.· :cMember of the Central Bureau of Procurement, Ministry of Economic Affairs, Bei Gong Xiao Cooperative Co., Ltd. printed Λ. # 'Members stated clearly whether the original suit was to be changed after the age of age 4 5 0 8 0 $ 86117553 Patent Application Chinese Manual Correction Page (88 October 2010) 5. Description of the invention (1) Introduction of the invention The present invention relates to liquid formulations containing insect repellent DEET, especially its emulsion formulations. People have used various chemicals for a long time to reduce annoying insects (such as Mosquitoes, Cangkan, Biyi, Wasps and Bees). The most widely used insect repellent currently is N, N-diethyl-m-toluidine, often called "DEET". DEET is oily, A little hygroscopic, light-sensitive oily substance has a very high dissolving power to other water-insoluble substances. Due to its shortcomings that it is not easy to emulsify, it is often made into a concentrated form or formulated as a spray or diluted solution, or a solid when used. Or semi-solid type, such as the strip type. To repel insects, people use DEET or formulations containing up to about 100% DEET on clothing and bare skin. However, 'People usually prefer the feeling of aqueous substances on the skin β Under makeup In the pharmaceutical and medical communities, 'oily substances combined with oil-in-water emulsions have been found to be more pleasing. Because the droplets of insoluble matter are completely surrounded by water, the skin feels like an aqueous substance when used. Emulsions are also more effective than solution sprays and Strip-like objects are easier to apply uniformly to the skin. However, DEETs are generally not able to be made into emulsions with the stability required commercially, and it is quite undesirable to require users to mix the separated materials before using the product. SUMMARY OF THE INVENTION The present invention includes a water-repellent insect emulsion in oil containing an effective amount of N, N · diethyl, m-toluidine, water, a film-forming polymer, and an emulsifier · emulsion stabilizer. This emulsion is commercially available Accepted storage stability and the pleasant feeling when used on the skin. 1: * ^^ 1 ^ ϋ— 1 ^ 1 ^^^ 1 · ί -I ί: (Please read the precautions on the back before copying this Page) Order -4-; 4S0806 | A7; B7 V. Description of the invention (2) Detailed description of the invention In this application, unless the context clearly indicates, all mentioned " percent " are weight percentages. This many formulation ingredients (surface (Emulsions, emulsion stabilizers, film-forming agents, etc.) are derived from the CTFA Cosmetic Ingredient Handbook edited by JA Wenninger et al., Second Edition, Beauty, Makeup, and Fragrance Association Company (The Cosmetic, Toiletry and Fragrance Association, Inc.), Washington, DC, 1992. Commercially available DEET is a technology street concentrate containing at least about 95% DEET. The remaining 5% or less is 5% Contains water and isomers other than m-toluene (other isomers are also considered to have some insect repellent effect), and a small amount of impurities used in the artificial process of the manufacturing process. Other ingredients should be ignored when DEET is concentrated: " 10% DEET " means a 10% commercial technology concentrate. The emulsion of the present invention comprises DEET (about 5 to about 25 percent), together with water, film-forming polymer and emulsifier emulsifier stabilizer. In some instances, supplementary emulsifiers can be used as ingredients in the formulation. ”The Consumer Cooperatives of the Central Standards Bureau of the Ministry of Economic Affairs printed suitable supplemental emulsifiers including (but not limited to) the surface-active agent stearic acid pear-sugar needle Sg, hard Fatty acid, sorbitol oleate, cetyl alcohol, glyceryl oleate, glyceryl stearate, Oh sorbitan sesquioleate, DEA-cetyl phosphate, oleyl ether-20 ( 01eth-20), PEG-8 distearate, PEG-8 oleate, PEG-2 stearate, polysorbate 20, polysorbate 60, polysorbate 80, stearic acid Malonyl ester, sodium laureth sulfate, gfg of sorbitol sesquioleate, and _____- 5j____ This paper size applies to Chinese national standards (CNS [a4 size (2 丨 OX297 mm) ~ 450806 Α7 Β7 V. Description of the invention (3) Many other agents are known in this technology. In general (remember there are many exceptions in this statement), the preparation of oil-in-water emulsions uses a hydrophilic-lipophilic balance (" HLB ") Emulsifiers from about 8 to about 18. Emulsifier compositions can also be used, and often more An emulsifier can produce better emulsification stability. When using the composition, all individual HLBs may not be all in the above range, but total HLBs are usually in this range. Da Zhao, when emulsifiers When the ingredient appears, its amount is about 0.1% to about 10% of the formulation. The film-forming polymer is added to provide continuous water resistance of the film and the formulation when used on the skin. Water resistance can help obtain insect repellents Prolonged action β This is particularly necessary for users who participate in water sports, such as fishing: water skiing, swimming or activities that may come in contact with water, or those who sweat heavily after participating in strenuous exercise or heavy work. Films include: copolymers of octadecane and maleic anhydride; copolymers of 1-trioxane and ethylene pyrrolidine; acrylate / octyl propylene amide copolymers; acrylate / PVP copolymers Acrylate / acrylamide copolymer; acrylate / VA copolymer; ethylene / maleic acid copolymer, polyisobutylene; polyvinyl alcohol; PVP / eicosane copolymer; starch / acrylate / acrylic acid Amine copolymers; and adipic acid Some of these ingredients usually account for about 0.1% to about 5% of the total formulation. 'Emulsifier-emulsion stabilizers, such as acrylic esters, are also needed in formulations. / C10-30 alkyl acrylate cross-linked polymer, polycarboxylate, methyl vinyl ether / maleic anhydride copolymer, or triethanolamine salt of stearic acid. Suitable commercially available acrylates / C10- 3 0 Alkyl acrylate cross-linked polymer is a product provided by BF Goodrich Chemicals, Akron, Ohio. It is named Pi Mulian ______- 6 · _ i paper size China National Standard (CNS) A4 (210X297 mm) 4 ^ 0806 Central Laboratories of the Ministry of Economic Affairs, Consumer Cooperatives, India, A7 B7 5. Description of Invention (4) (PEMULEN®) TR-1 and TR-2, Or CARBOPOL®. The concentration of the emulsifier-emulsion stabilizer in a typical formulation is from about 0.01% to about 5%. It has been found in some formulations that the concentration of the emulsifying stabilizer, Pycnogenol TR-2, should not exceed about 0.8%, in order to avoid increasing the viscosity and affecting the preparation and handling of the emulsion. Other non-essential ingredients are often included in skin care products to enhance the feel of use, condition dry skin, and / or prevent microbial contamination of the formulation. These include emollients, fragrances, preservatives, vitamins' wetting agents, skin conditioners, antioxidants and others. In addition to the essential ingredients, any of the above substances can be added as needed. Sunscreen ingredients are also practical and optional ingredients in formulations, especially when users also need to protect against excessive UV exposure. Since the choice of sunscreen active drugs is usually limited to officially approved ingredients, those skilled in the art know those Is an acceptable mixture. In the United States, currently there are: aminobenzoic acid; p-methoxycinnamoethoxyethyl (cinoxate); diethanolamine p-methoxycinnamate; dimethyl trioleate; dioxophenone; 4- [di (Hydroxypropyl)] aminobenzoic acid ethyl ester; 2-cyano-3,3-diphenylacrylic acid 2-ethylhexyl ester; ethylhexyl p-methoxycinnamate; 2-ethylhexyl salicylate Esters; glyceryl amine benzoate: trimethylcyclohexyl salicylate; 2-hydroxy-1., ...- dimethyamine containing dihydroxyacetone; menthol mentholate; oxyphenone; pardimeline Padimate A; Padimet; · Phenyl benzimidazole _ 5_ sulfonic acid; Redstone 'sulisobenzone and triethanolamine salicylic acid' other active anti-warming ingredients' such as love Fobenzyl (avobenzone), dioxin and phenylbenzimidazole sulfonic acid are approved for use in many countries, and can also be added to the insect repellent formulation of the present invention. The size of this paper is universal Chinese national ladder (CNS) A4 size (210X297 public love) (Please read the precautions on the back before filling this page) vm. ·: C

*1T A7 450806 _B7_ 五、發明説明（5 ) 可視所需有效防曬劑量來使用防曬成分以提供所需之太 陽保護因子（Sun Protection Factor, SPF )，S P F的測量最少可 使用美國食品與藥物管理局（the United States Food and Drug Administration)所提出建立程序的要義（見標題21、聯邦管制 代碼、第352部、次部D(第352.70352.77節），此提議於 1 993年五月12日在聯邦登記第28298_28301頁出版。大體 上，可使用高達約30百分比的防曬劑。 本發明將會進一步以下列實例説明，這些實例並非意欲 限制後附本發明申請專利所定義的範圍。 發明實例 , 實例1 (請先閱讀背面之注意事項再填寫本页) 經濟部中央標準局負工消費合作社印製 以下列成分製備儲存-穩定的驅昆蟲乳劑： 名 稱 百分比 水 41.89 安息香酸C 12-15烷酯 C 21.50 DEET D 10.00 山梨糖醇，70%水性溶液 B 5.00 油酸山梨糖醇酐酯 C 4.00 硬脂酸山梨糖醇酐酯 C 3.00 硬脂酸甘油酯，自行乳化 _ C 3.00 硬脂酸 C 2.00 十八晞/順丁烯二酸酐共聚物 C 2.00 氫化蔬菜油 C 2.00 三乙醇胺 B 1.80 ___ ~ 8 - 本紙張尺度適用中國國家榡牟（CNS ) Λ4規格(21 Ox 297公釐） 450806 Α7 Β7 五、發明説明（6〉 苯甲醇 E 1.00 對羥苯甲酸丙酯 C 1.00 香料 E 0.70 二甲基聚碎氧垸（Dimethicone ) C 0.40 羥苯甲酸甲酯 C 0.20 咪唑烷基尿素 F 0.20 匹木蓮TR-2 A 0.10 維他命E C 0.10 荷荷芭油（Jojoba oil) C 0.05 產薈力拍奎傻（Aloe vera lipoquinone) C 0.05 E D T A 二鈉 B 0.01 *英文字母表示此成份在特定製備步驟中加入。 經濟部中央揉率扃負工消费合作社印掣 乳劑之製備如下：（1)除一小部分外，將所有的水和匹木 蓮TR-2混合形成透明溶液並加熱至約60-65°C ; (2)上面標 示”B"的成份陸續加入步驟1溶液，混合溶解；（3)除維他命 E'代美希孔及十八烯/順丁烯二酸酐共聚物以外，將所有 標示"C"的成份混合，形成一溶液並加熱至約8 2 - 8 5 °C ; (4)將十八烯/順丁烯二酸肝共聚物加入、溶入步骤3旄合 •物中；（5)將步驟4混合物冷卻至約65-71°C，並將剩餘的 成份加入、溶解；（6)將溫的"D"成份加入溫的步驟5混 合物中並溶解之；（7)將步驟6溶液加入步驟2溶液中，充分 攪拌以形成乳劑’並持績混合直到乳劑降溫至約49-54Ό ; (8)將"E”成份加入步驟7乳劑中，並繼續混合；（9)將剩餘 的水和"G"成份混合形成溶液，然後加到步银8乳劑中；且 —----- --- 9 -_ 本紙張尺度逋用中國囡家標隼（CNS) M規格（210><297公釐） ~~~ 450806 Α7 Β7 五、發明説明（7 ) (10)讓乳劑冷卻到室溫並加入水以補償在製備期間蒸發的 損失。 實例2 以下列成分和與前例相同之一般程序製備含充份防曬成 份以提供防水的太陽保護因子（SPF)15之儲存-穩定的驅昆 蟲乳劑： 水 42-79 DEET 1〇 00 肉桂酸辛基甲氧酯 水楊酸辛酯 5‘00 水揚酸高薄荷腦酯 5.00 山梨糖醇，70%水性溶液 5.00 氧苯酮 4.00 油酸山梨糖醇酐酯 4.00 硬脂酸甘油酯，自行乳化 硬脂酸山梨糖醇酐酯 3.00 0 硬脂酸 2·(Η> 經濟部中央標準局負工消費合作社印製 -氫化蔬菜油 2·〇〇 十八烯/順丁烯二酸酐共聚物_ 2.00 三乙醇胺 I·80 苯甲醇 1.00 香料 〇_7〇 二甲基聚矽氧烷 〇·40 _-10- 本紙浪尺度適用中國國家標準（CNS ) Α4規格（2丨0X297公釐) 450806 五、發明説明（8 ) 經濟部中央標準局員工消費合作社印製 A7 B7 羥苯甲酸曱酯 0.20 咪唑坑基尿素 0.20 匹木蓮TR-2 0.10 對羥苯甲酸丙酯 0.10 維他命E 0.10 荷荷包油（Jojoba oil) 0.05 產薈力 ί6 奎儂（Aloe Vera lipoquinone ) 0.05 EDTA 二鈉 0.01 在此乳劑之製備時，將防曬活性成分以"C' '成份加入。 實例3 使用那些下列成分製備一包含充份的防曬成份以提供防 水SPF30之儲存-穩定的驅昆蟲乳劑： 名 稱 1 百分比 水 57.09 水楊酸高薄荷腦酯 B 13.00 DEET D 10.00 肉桂酸辛基曱氧酯 B 7.50 羥基苯甲酮 B 6.0 0’ 山梨糖醇，70%水性溶液 A 2.00 十八烯/順丁烯二酸酐共聚物二 C 2.00 三乙醇胺 A 1.00 二甲基聚矽氧烷 C 0.40 匹木蓮TR-2 A 0.30 香料 E 0.30 訂 -11 - 本紙張尺度適用中國國家標準（CNS ) A4规格（210X297公釐） j 460806 ί A7 ! . _ _ B7 j 一 i 五、發明説明（9 ) 咪唑烷基尿素 F 0.20 維他命Ε B 0.10 度薈力拍奎儂（Aloe Vera Hpoquinone ) B 0.05 荷荷芭油（Jojoba oil) B 0.05 EDTA 二鈉 A 0.01 *英文字母表示此成份在特定製備步驟中加入、 乳劑之製備如下：（1)除一小部分外，將所有的水和標示 的成份混合並加熱至約49-55 *C形成溶液；（2)將標示 "B"的成份混合並加熱至約80-82°C形成溶液；（3)陸續將 所有標示"C ”的成份加入步驟2溶液中，每次加入蒔皆充分 混合形成溶液；（4)將步驟3溶液冷卻至約62-68°C ; (5)將 DEET加入步驟4溶液中，完全混合；（6)攪拌步驟1溶液形 成旋渦並緩慢加入步驟5溶液，形成乳劑，持續混合至混合 物降溫[約49-52°C ; (7)將香料加入步驟6混合物中，持續 混合並冷浴至周園溫度；（8)將"F·，成份溶於剩餘的水中並 加入步驟7混合物中；（9)混合加入足量水以補償在製備期 間蒸發的損失。 -/\ C請先聞讀背面之注意事項再填寫本頁)* 1T A7 450806 _B7_ V. Description of the Invention (5) The sunscreen ingredients can be used to provide the required Sun Protection Factor (SPF) according to the effective sunscreen dose required. The SPF can be measured at least by the US Food and Drug Administration (The United States Food and Drug Administration) (see Title 21, Federal Control Code, Part 352, Subpart D (Section 352.70352.77), this proposal was submitted on May 12, 1993 Published on Federal Register, pages 28298_28301. In general, up to about 30% of sunscreens can be used. The present invention will be further illustrated by the following examples, which are not intended to limit the scope defined by the appended patent application. Examples of invention, examples 1 (Please read the notes on the back before filling this page) Printed by the Central Standards Bureau of the Ministry of Economic Affairs, Consumer Cooperatives to prepare a storage-stable insect repellent emulsion with the following ingredients: Name Percent Water 41.89 Benzoic Acid C 12-15 Alkyl C 21.50 DEET D 10.00 Sorbitol, 70% aqueous solution B 5.00 Sorbitol oleate C 4.00 Sorbate stearate Sugar alcohol anhydride ester C 3.00 Glyceryl stearate, self-emulsifying _ C 3.00 Stearic acid C 2.00 Octadecane / maleic anhydride copolymer C 2.00 Hydrogenated vegetable oil C 2.00 Triethanolamine B 1.80 ___ ~ 8-This paper Standards are applicable to China National Standards (CNS) Λ4 specifications (21 Ox 297 mm) 450806 Α7 Β7 V. Description of the invention (6> benzyl alcohol E 1.00 propyl paraben C 1.00 perfume E 0.70 dimethyl polyoxysilane (Dimethicone) C 0.40 methyl paraben C 0.20 imidazolidinyl urea F 0.20 Pycnogenol TR-2 A 0.10 vitamin EC 0.10 Jojoba oil C 0.05 Aloe vera lipoquinone C 0.05 EDTA disodium B 0.01 * The English alphabet indicates that this ingredient is added in a specific preparation step. The Central Ministry of Economic Affairs, Kneading Labor Cooperative Consumer Cooperative Printing Emulsion is prepared as follows: (1) Except for a small portion, all water and Hibiscus TR-2 is mixed to form a transparent solution and heated to about 60-65 ° C; (2) The ingredients marked "B " are added to the solution in step 1 one after the other, mixed and dissolved; (3) In addition to vitamin E 'Daimeki and ten Octaene / maleic acid In addition to the copolymer, all the ingredients marked with "C" are mixed to form a solution and heated to about 8 2-8 5 ° C; (4) octadecene / maleic acid liver copolymer is added and dissolved in Step 3 is combined with the material; (5) The step 4 mixture is cooled to about 65-71 ° C, and the remaining ingredients are added and dissolved; (6) the warm " D " ingredients are added to the warm step 5 mixture (7) Add the solution from Step 6 to the solution from Step 2, stir thoroughly to form an emulsion, and keep mixing until the emulsion temperature drops to about 49-54Ό; (8) Add the "E" ingredient to the emulsion from Step 7. Medium, and continue mixing; (9) the remaining water and "G" ingredients are mixed to form a solution, and then added to the step silver 8 emulsion; and ------- --- 9 -_ This paper size is not used Chinese Standard House (CNS) M specification (210 > < 297 mm) ~~~ 450806 Α7 Β7 V. Description of the invention (7) (10) Allow the emulsion to cool to room temperature and add water to compensate for evaporation during preparation Loss. Example 2 A storage-stable insect repellent emulsion containing sufficient sunscreen ingredients to provide water-resistant sun protection factor (SPF) 15 was prepared with the following ingredients and the same general procedure as in the previous example: Water 42-79 DEET 1000 octyl cinnamate Octyl salicylate 5'00 homomenthyl salicylate 5.00 sorbitol, 70% aqueous solution 5.00 oxybenzone 4.00 sorbitan oleate 4.00 glyceryl stearate, self-emulsifying sorbitan stearate Sugar Alcohol Anhydride Ester 3.00 0 Stearic Acid 2 · (Η > Printed by the Consumers' Cooperative of the Central Standards Bureau of the Ministry of Economics-Hydrogenated Vegetable Oil 2.0. Octadecene / Maleic Anhydride Copolymer_ 2.00 Triethanolamine I · 80 benzyl alcohol 1.00 fragrance 〇_70 dimethyl polysiloxane -40 · _-10- This paper wave standard is applicable to China National Standard (CNS) A4 specification (2 丨 0X297 mm) 450806 5. Description of the invention (8) Printed by the Consumers Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs A7 B7 Ethyl paraben 0.20 Imidazole Phenyl urea 0.20 Pyrenox TR-2 0.10 Propyl paraben 0.10 Vitamin E 0.10 Jojoba oil 0.05 Productivity ί6 Aloe Ve ra lipoquinone) 0.05 disodium EDTA 0.01 In the preparation of this emulsion, the sunscreen active ingredients were added as " C '' ingredients. Example 3 Use those ingredients listed below to prepare a storage-stable SPF30 that contains sufficient sunscreen ingredients to provide water resistance Insect repellent emulsion: Name 1 percent water 57.09 homomenthyl salicylate B 13.00 DEET D 10.00 octyl oxycinnamate B 7.50 hydroxybenzophenone B 6.0 0 'sorbitol, 70% aqueous solution A 2.00 18 Ene / maleic anhydride copolymer two C 2.00 Triethanolamine A 1.00 Dimethyl polysiloxane C 0.40 Pyrenox TR-2 A 0.30 Spice E 0.30 Order -11-This paper size applies to Chinese National Standard (CNS) A4 Specifications (210X297 mm) j 460806 ί A7!. _ _ B7 j i i 5. Description of the invention (9) Imidazolidinyl urea F 0.20 Vitamin E B 0.10 Aloe Vera Hpoquinone B 0.05 Jojoba oil B 0.05 EDTA disodium A 0.01 * The English letter indicates that this ingredient is added in a specific preparation step. The emulsion is prepared as follows: (1) Except for a small part, all water and standard The ingredients are mixed and heated to about 49-55 * C to form a solution; (2) The ingredients marked " B " are mixed and heated to about 80-82 ° C to form a solution; (3) all the tags " C are successively added " The ingredients are added to the step 2 solution, and each time dill is added, the mixture is thoroughly mixed to form a solution; (4) the step 3 solution is cooled to about 62-68 ° C; (5) DEET is added to the step 4 solution and mixed thoroughly; (6) ) Stir the solution from step 1 to form a vortex and slowly add the solution from step 5 to form an emulsion. Continue mixing until the mixture cools down [about 49-52 ° C; (7) Add perfume to the mixture from step 6, continue to mix and cool to the ambient temperature. (8) Dissolve " F ·, the ingredients are dissolved in the remaining water and added to the mixture in step 7; (9) Mix and add a sufficient amount of water to compensate for the loss of evaporation during preparation. -/ \ C Please read the notes on the back before filling in this page)

,1T 經濟部中央標準局貝工消资合作社印製 I賴一躲 I本 率 標 家 一國 國 12 I餐 公 7 9 2, 1T Printed by the Shell Industry Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs

Claims (1)

410 8 06 第861Π553號專利中請案 中文t請牟利範叱修正本(90年6月） A8 B8 C8 D8 ’备，Hi 六 中Μ利，告本 經濟部t央搮率局負工消费合作社印«. 1 —種驅昆蟲乳劑組合物，其係包含：一種有效驅蟲劑量 的N，N-二乙基-間甲苯醯胺；水；〇.1到5重量百分比之成 膜聚合物，其係選自下列群组：十八烯和順丁烯二酸奸 的共聚物’ 1-三十烷和乙缔基吡咯烷酮的共聚物，丙埽 酸酯/辛基丙烯醯胺共聚物，丙烯酸酯/PVP共聚物， 丙烯酸酯/丙烯醯胺共聚物，丙晞酸酯/VA共聚物，乙 烯/順丁烯二酸酐共聚物、聚異丁烯，聚乙烯醇，PVp /二十烷共聚物，澉粉/丙烯酸酯/丙烯醯胺共聚物， 己二酸聚合物’及其中任兩者或更多者的混合物；〇.〇1 到5重量百分比之乳化劑-乳液安定劑，其係選自下列群 组：丙烯酸酯/C10-30烷基丙烯酸酯交鏈聚合物，聚幾 乙烯製劑，甲基乙烯基瞇/順丁烯二酸酐共聚物，硬脂 酸與三乙醇胺的鹽類，及其中任兩者或更多者的混合 物；以及’任意地，〇. 1到10重量百分比之乳化劑，其係 選自下列群組：硬脂酸山梨糖醇酐酯、硬脂酸、油酸山 梨搪醇酐酯、鯨蠟醇、油酸甘油酯、硬脂酸甘油酯'倍 半油酸山梨糖醇酐酯 '磷酸DEA-鯨蠟酯、油醇瞇_ 20(01eth-20)、PEG-8 二硬脂酸酯、PEG-8 油酸酯、PEG- 2硬脂酸酯、聚山梨酸酯20、聚山梨酸酯60、聚山梨酸酯 80、硬脂酸丙二醇酯、月桂醇醚硫酸酯鈉（s〇diUm laureth sulfate)、倍半油酸山梨糖醇酐酯及其中任兩者或更多者 的混合物9 2根據申請專利範固第1項之組合物，進一步包含乳化劑。 3根據中請專利範圍第1項之組合物，其中DEET之含量為 ----------^-------^1.-----0 , - (請先《讀背面之注f項再填寫本貰) 本纸張尺度適用中觸蘭家捸率（CNS ) A4規格{ 公釐）410 8 06 Patent No. 861Π553 Requested in Chinese t Please profit for the revised version (June 90) A8 B8 C8 D8 'Equipment, Hi Six Middle Schools, and profit, the Ministry of Economic Affairs t Central Government led the bureau of the off-work consumer cooperative Yin «. 1-an insect repellent emulsion composition comprising: an effective insect repellent dose of N, N-diethyl-m-toluidine; water; 0.1 to 5 weight percent of a film-forming polymer, It is selected from the group consisting of: copolymers of octadecene and maleic acid, 'copolymers of 1-trioxane and ethylpyrrolidone, copolymers of propionate / octylpropenamide, acrylic acid Ester / PVP copolymer, acrylate / acrylamide copolymer, propionate / VA copolymer, ethylene / maleic anhydride copolymer, polyisobutylene, polyvinyl alcohol, PVp / eicosane copolymer, 二十Powder / acrylate / acrylamide copolymer, adipic acid polymer 'and a mixture of any two or more thereof; 0.01 to 5 weight percent of an emulsifier-emulsion stabilizer, which is selected from the following Group: Acrylate / C10-30 Alkyl Acrylate Cross-linked Polymer, Polyethylene Preparation, Methyl Vinyl Acrylate / Maleic anhydride copolymers, salts of stearic acid and triethanolamine, and mixtures of any two or more thereof; and 'optionally, 0.1 to 10 weight percent of an emulsifier, which is selected From the group: sorbitan stearate, stearic acid, sorbitan oleate, cetyl alcohol, glyceryl oleate, glyceryl stearate, sorbitan sesquioleate 'DEA-Cetyl Phosphate, oleyl alcohol 20 (01eth-20), PEG-8 distearate, PEG-8 oleate, PEG-2 stearate, polysorbate 20, poly Sorbate 60, polysorbate 80, propylene glycol stearate, sodium lauryl sulfate, sorbitan sesquioleate, and any two or more thereof Mixture 9 2 The composition according to item 1 of the patent application, further comprising an emulsifier. 3 The composition according to item 1 of the patent scope, wherein the content of DEET is ------------ ^ ------- ^ 1 .----- 0,-(please first "Read the note f on the back side and fill in this note) The paper size is applicable to the medium-to-blue furniture ratio (CNS) A4 specification {mm) 六、申請專利範面 5到25重量百分比》 4·根據申請專利範面第1項之組合物，其進_一步包含有效防 曬劑量的防曬劑。 5根據申請專利範面第4項之组合物，其中的防瞜劑係選自 下列群组中：胺基苯甲酸；對甲氧肉桂乙氧乙酯 (cinoxate);二乙醇胺對甲氧基肉桂酸鑷；三油酸二掊 趄；二氧苯酮；4-[二（羥丙基）]胺基苯甲酸乙酯；2-氰 基-3,3·二苯基丙烯酸2-乙基己酯；對甲氧基肉桂酸乙基 己酯；水揚酸2·乙基己酯；胺基苯甲酸甘油酯；水揚酸 三甲環己酯；含二羥基丙嗣之2-羥-1,4-苯二酮 (lawsone);胺茴酸薄荷腦基發；氧苯酮；帕第梅特 A(Padimate A);帕第梅特Ο ; 2-苯基苯并咪咬-5·續 酸；紅石蠟；硫異苯酮（sulisobenzone);三乙醉胺水楊酸 路；愛佛苯萌（avobenzone);二氧化鈇；苯基苯并咪吐續 酸；及其中任兩者或更多者的混合物。 6根據申請專利範圍第4項之組合物，其中防曬劑含量最多 達30重量百分比。 7根據申請專利範圍第1項之组合物，包含： ⑻5到25重量百分比之Ν,Ν-二乙基-間〒苯醯胺； (b) 0.1到5重量百分比之成膜聚合物，其係選自下列群 組：十八烯和順丁烯二酸酐的共聚物；1-三十烷和 乙缔基》比洛境朗的共聚物；丙缔酸醋/辛基丙缔磁 胺共聚物；丙烯酸酯/PVP共聚物；丙烯酸酯/丙 缔醯胺共聚物；丙烯酸酯/VA共聚物；乙埽/順丁 -2- 本纸浪尺度適用中國家#準（CNS > Α4洗修（210X297公着） ^^^^1 ^—ϋ^— LmL ►w _ i -- (.- {請先《讀背ft之注$項再填窝本f ，訂_ 趄濟部+央樑率局Λ工消费合作社印装 450 8 〇 6 A8 C8 D8 經濟部中央橾率扃員工消费合作社印*. π、申請專利範圍 埽二酸衧共聚物、聚異丁烯；聚乙缔醇；PVP/二十 燒共聚物；渡粉/丙烯酸酯/丙烯醯胺共聚物；己 二酸的聚合物；及其中任兩者或更多者的混合物； (C) 0.01到5重量百分比之乳化劑-乳液安定劑，其係選 自下列族群：丙烯酸酯/C10-30烷基丙烯酸酯交缝 聚合物，聚羧乙烯製劑（carbomer)，甲基乙缔基鍵/ 順丁烯二酸酐共聚物，硬脂酸與三乙酵胺的鹽類， 及其中任兩者或更多者的混合物，·和 ⑼水。 - 8根據申請專利範圍第7項之組合物，進一步包含到1〇 重量百分比之HLB值為8到18的乳化劑。 9根據申請專利範圍第7項之組合物，進一步包含有效防曬 劑量的防曬劑。 10根據申請專利範園第9項之组合物，其中防曬劑係選自下 列族群中：胺基苯甲酸；對甲氧肉桂乙氧乙酯；二乙醇 胺對甲氧基肉桂酸酯；三油酸二格醯；二氧苯酮[二 (巍丙基）]胺基苯甲酸乙酯；2-氰基-3,3-二苯基丙烯酸 2 -乙基己酯；對甲氧基肉桂酸乙基己酯；水揚酸2_乙基 己酯；胺基苯甲酸甘油酯；水揚酸三甲環己酯；含二羥 基丙明之2-羥-1,4-苯二嗣；胺茴酸薄荷腦基酯；氧苯 明；帕第梅特A ;帕第梅特〇 ; 2-苯基苯并咪唑-5-磺 酸；紅石蠟；硫異苯酮；三乙醇胺水揚酸酯；愛佛苯 綱；二氧化鈦；苯基苯并咪唑磺酸；及其中任兩者或更 多者的混合物· - 3 · 本紙張尺度逋用中•國家樣率（CNS )八4規格（210X297公釐） (請先Η讀背面之注項再填寫本頁) 裝· •.訂 線 4§〇8〇6 經濟部中央樑牟局Wi工消费合作社印策 A8 B8 C8 D8 A、申請專利範圍 1 1根據申請專利範圍第9項之組合物，其中的防曬劑含量最 多30重量百分比。 1 2根據申請專利範圍第I項之組合物，包含： (a) 5到25重量百分比之Ν,Ν-二乙基-間甲苯醢胺； (b) 0.1到5重量百分比之成膜聚合物，其係選自下列群 組：十八缔和順丁烯二酸酐的共聚物；i —三十烷和 乙雄基吡咯烷酮的共聚物；丙烯酸酯/辛基丙缔睹 胺共聚物；丙烯酸酯/PVP共聚物；丙烯酸酯/丙 烯醯胺共聚物；丙浠酸酯/VA共聚物；乙烯/順丁 燁二酸酐共聚物、聚異丁烯；聚乙烯醇；PVP/二十 烷共聚物；濺粉/丙婦酸酯/丙烯醢胺共聚物；己 二酸聚合物；及其中任兩者或更多者的混合物； (c) 001到5重量百分比之乳化劑-乳液安定劑，選自下 列族群：丙烯酸酯/C10-30烷基丙烯酸酯交鏈聚合 物，聚羧乙烯製劑，甲基乙烯基醚/順丁蟑二酸酐 共聚物，硬脂酸與三乙醇胺的鹽類，及其中任兩者 或更多者的混合物； (d) 水； (e) 最多達10重量百分比之HLB值為8到18的乳化 劑；和 (f) 最多達30重量百分比之防曬劑，其係由下列族群選 出：胺基苯甲酸；對甲氧肉桂乙氧乙酯；二乙醇胺 對甲氧基肉桂酸酯；三油酸二掊酯醯酯；二氧苯 酮；4-[二（羥丙基）]胺基苯甲酸乙酯；2-氰基-3,3- -4- 本紙張尺度適用中«蹰家揲率（CNS ) A4规格{ 210X297公釐） (请先闓讀背A之注^^項再填寫本賓) I.訂 45〇8〇6 A8 B8 C8 D8 、申請專利範圍 二苯基丙埽酸2-乙基己酯；對甲氧基肉桂酸乙基己 酯；水楊酸2-乙基己酯；胺基苯甲酸甘油酯；水楊 酸二甲環己醋，含一幾基丙嗣之2 -幾· l，4-茶二明； 胺茴酸薄荷腦基酿；氧苯酮；帕第梅特A;帕第梅 特0 ’ 2-苯基苯并咪唆-5-磺酸；紅石壤；硫異苯 酮；三乙醇胺水揚酸酯；愛佛苯酮；二氧化鈦；苯 基苯并咪峻確酸’及其中任兩者或更多者的混合 物。 (請先《讀背面之注$項再填寫本萸) •潘. 11·, Γ 經濟部中央揲率局貝工消費合作社印«. 本紙張尺度速用中_寓家#準（CNS ) A4供并（210X297公優） Α7 Β7VI. Patent application scope 5 to 25% by weight "4. The composition according to item 1 of the patent application scope, which further comprises a sunscreen with an effective sunscreen dose. 5 The composition according to item 4 of the patent application, wherein the mothproofing agent is selected from the group consisting of: aminobenzoic acid; p-methoxycinnamon ethoxyethyl (cinoxate); diethanolamine p-methoxycinnamon Acid tweezers; dihydrazone trioleate; dioxophenone; ethyl 4- [di (hydroxypropyl)] aminobenzoate; 2-cyano-3,3 · diphenylacrylic acid 2-ethylhexyl Esters; ethylhexyl p-methoxycinnamate; 2-ethylhexyl salicylate; glyceryl aminobenzoate; trimethylcyclohexyl salicylate; 2-hydroxy-1,4 -Benzodione (lawsone); anthranilic menthol-based hair; oxybenzone; Padimet A (Padimate A); Padimet 0; 2-phenylbenzimidone bite-5 · continuous acid; Red paraffin; sulisobenzone; triethylsalamine salicylic acid road; avobenzone; osmium dioxide; phenylbenzimiduronic acid; and any two or more thereof mixture. 6 The composition according to item 4 of the patent application scope, wherein the sunscreen content is up to 30% by weight. 7 The composition according to item 1 of the scope of patent application, comprising: ⑻5 to 25% by weight of N, N-diethyl-m-phenylbenzamide; (b) 0.1 to 5% by weight of a film-forming polymer, which is Selected from the group consisting of: copolymers of octadecene and maleic anhydride; copolymers of 1-trioxane and ethylidene bilopiron; acrylic acid / octyl allylamine copolymers ; Acrylate / PVP copolymer; acrylate / acrylamide copolymer; acrylate / VA copolymer; acetamidine / cis-butyl-2- This paper is suitable for China #standard (CNS > Α4washing ( 210X297) ^^^^ 1 ^ —ϋ ^ — LmL ►w _ i-(.- {Please read the note of ft, then fill in the book f, and order _ Ministry of Economic Affairs + Central Liang rate Printed by the Bureau of Industrial Cooperatives 450 8 〇6 A8 C8 D8 Printed by the Central Government of the Ministry of Economic Affairs and printed by the Consumer Cooperatives of Employees *. Π, the scope of application for patents, diacid copolymers, polyisobutylene; polyethylene glycol; PVP / 20 Fired copolymer; powder / acrylic acid / acrylamide copolymer; polymer of adipic acid; and a mixture of any two or more thereof; (C) 0.01 to 5 weight percent of emulsifier -Emulsion stabilizers, which are selected from the group consisting of: acrylates / C10-30 alkyl acrylate cross-linked polymers, carbomers, methyl ethylenic bonds / maleic anhydride copolymers, Stearic acid and triethionamine salts, and mixtures of any two or more thereof, and hydrazone.-8 The composition according to item 7 of the scope of patent application, further comprising up to 10% by weight An emulsifier having an HLB value of 8 to 18. 9 The composition according to item 7 of the patent application scope, further comprising an effective sunscreen dose. 10 The composition according to item 9 of the patent application park, wherein the sunscreen agent is selected from the group consisting of In the following groups: Aminobenzoic acid; p-methoxycinnamoethoxyethyl ester; diethanolamine p-methoxycinnamate; dilatamine trioleate; dioxophenone [bis (weipropyl)] aminobenzene Ethyl formate; 2-ethylhexyl 2-cyano-3,3-diphenylacrylate; ethylhexyl p-methoxycinnamate; 2-ethylhexyl salicylate; glyceryl aminobenzoate Esters; trimethylcyclohexyl salicylate; 2-hydroxy-1,4-benzenedifluorene with dihydroxypropylamine; mentholate of anthranilic acid; oxygen Ming; Padimet A; Padimet 0; 2-phenylbenzimidazole-5-sulfonic acid; red paraffin; thioisophenone; triethanolamine salicylate; ephedrone; titanium dioxide; benzene Benzimidazole sulfonic acid; and a mixture of any two or more of them--3 · This paper size is in use • National Sample Rate (CNS) 8 4 (210X297 mm) (Please read the back Please fill in this page if you have noted the items.) Assembling · •. 4 4 0 8 0 6 Ministry of Economic Affairs Central Liang Mou Bureau Wi Industry Consumer Cooperatives India policy A8 B8 C8 D8 A, scope of patent application 1 1 According to item 9 of scope of patent application The composition has a sunscreen content of up to 30 weight percent. 1 2 The composition according to item I of the scope of patent application, comprising: (a) 5 to 25 weight percent N, N-diethyl-m-toluidine; (b) 0.1 to 5 weight percent film-forming polymer , Which is selected from the group consisting of: copolymers of octadecyl and maleic anhydride; copolymers of i-trioxane and ethynylpyrrolidone; acrylate / octylpropylamine copolymers; acrylate / PVP copolymer; acrylate / acrylamide copolymer; propionate / VA copolymer; ethylene / maleic anhydride copolymer, polyisobutylene; polyvinyl alcohol; PVP / eicosane copolymer; splash powder / A hyaluronic acid / acrylamide copolymer; an adipic acid polymer; and a mixture of any two or more thereof; (c) an emulsifier-emulsion stabilizer from 001 to 5 weight percent, selected from the following groups: Acrylate / C10-30 Alkyl Acrylate Cross-linked Polymer, Carboxylic Acid Formulation, Methyl Vinyl Ether / Butanedioic Anhydride Copolymer, Salts of Stearic Acid and Triethanolamine, and Any Two or A mixture of more; (d) water; (e) milk with an HLB value of 8 to 18 up to 10 weight percent Agents; and (f) sunscreens up to 30 weight percent, selected from the following groups: aminobenzoic acid; p-methoxycinnamoethoxyethyl ester; diethanolamine p-methoxycinnamate; dioleate Phenyl ester Phenyl ester; Dioxophenone; 4- [Di (hydroxypropyl)] aminobenzoic acid ethyl ester; 2-cyano-3,3- -4- CNS) A4 specification {210X297 mm) (please read the note ^^ of A before filling in this guest) I. order 45〇80〇6 A8 B8 C8 D8, the scope of patent application diphenylpropanoic acid 2- Ethylhexyl ester; Ethylhexyl p-methoxycinnamate; 2-Ethylhexyl salicylate; Glyceryl aminobenzoate; Dimethylcyclohexyl salicylate, containing 2-1-propylpropanone- Ch. L, 4-Teamin; anthranilic menthol; oxyphenone; Padimet A; Padimet 0 '2-phenylbenzimidazine-5-sulfonic acid; redstone soil Thioisophenone; triethanolamine salicylate; ephedrone; titanium dioxide; phenyl benzimidate and mixtures of any two or more thereof. (Please read "Notes on the back of the book before filling in this book") • Pan. 11 ·, Γ Printed by the Shellfish Consumer Cooperative of the Central Bureau of Economic Affairs of the Ministry of Economic Affairs «. This paper is in quick use _ 所 家 # 准 （CNS） A4 Supply and supply (210X297 public excellent) Α7 Β7 經济部中央樣準局貝工消f合作社印装 Λ.#'委員明示，本裳齡正後是否變更原實贺内溶 4 5 〇 8 0 $第86117553號專利申請案 中文說明書修正頁(88年10月） 五、發明説明（1 ) 發明介紹 本發明係有關於含驅昆蟲藥DEET的液體調配物，特別 是其乳劑調配物* 人們長久以來使用過各種不同化學藥劑來減少惱人昆蟲（ 如蚊子、蒼堪、壁益、黃蜂和蜜蜂）的攻擊〇目前最廣泛使 用的驅昆蟲藥為Ν,Ν-二乙基-間甲苯醯胺，常被稱為 ”DEET·'。DEET為油性、有點吸濕性、光敏感性的油狀物 ，對其它不溶水的物質具有非常高的溶解力。由於其不易 乳化的缺點，使用時常製為濃縮型式或配成喷霧或稀釋溶 液，或固體或半固體型，如條型。為驅逐昆蟲，人們使用 DEET或含高達约l〇〇%DEET的調配物在衣服及裸露的皮 膚上。 然而’人們通常較喜歡水性物質在皮膚上的感覺β在化 妝品和醫學界中’已發現與水中油乳劑結合的油性物質更 討人喜歡。由於不溶解物質小滴完全被水包圍，使用時皮 膚的感覺就如同水性物質一樣。乳劑也比溶液喷劑和條型 勝狀物更易於均勻使用於皮膚上。然而，DEET通常無法 製成具有商業上所需安定性的乳劑，且要使用者在使用產 品前將分開之物相加以混合是相當不受歡迎的。 發明概要 本發明包括含有效量的Ν，Ν·二乙基，間甲苯醯胺、水、 成膜聚合物和乳化劑·乳劑安定物之油中水驅昆蟲乳劑。 此乳劑具商用可接受的儲存安定性和使用在皮膚時令人 喜愛的感覺。 1 :* ^^1 ^ϋ— 1^1 ^^^1 ·ί -I ί: : (請先Μ讀背面之注意事項再本頁) 訂 -4- 410 8 06 第861Π553號專利中請案 中文t請牟利範叱修正本(90年6月） A8 B8 C8 D8 ’备，Hi 六 中Μ利，告本 經濟部t央搮率局負工消费合作社印«. 1 —種驅昆蟲乳劑組合物，其係包含：一種有效驅蟲劑量 的N，N-二乙基-間甲苯醯胺；水；〇.1到5重量百分比之成 膜聚合物，其係選自下列群组：十八烯和順丁烯二酸奸 的共聚物’ 1-三十烷和乙缔基吡咯烷酮的共聚物，丙埽 酸酯/辛基丙烯醯胺共聚物，丙烯酸酯/PVP共聚物， 丙烯酸酯/丙烯醯胺共聚物，丙晞酸酯/VA共聚物，乙 烯/順丁烯二酸酐共聚物、聚異丁烯，聚乙烯醇，PVp /二十烷共聚物，澉粉/丙烯酸酯/丙烯醯胺共聚物， 己二酸聚合物’及其中任兩者或更多者的混合物；〇.〇1 到5重量百分比之乳化劑-乳液安定劑，其係選自下列群 组：丙烯酸酯/C10-30烷基丙烯酸酯交鏈聚合物，聚幾 乙烯製劑，甲基乙烯基瞇/順丁烯二酸酐共聚物，硬脂 酸與三乙醇胺的鹽類，及其中任兩者或更多者的混合 物；以及’任意地，〇. 1到10重量百分比之乳化劑，其係 選自下列群組：硬脂酸山梨糖醇酐酯、硬脂酸、油酸山 梨搪醇酐酯、鯨蠟醇、油酸甘油酯、硬脂酸甘油酯'倍 半油酸山梨糖醇酐酯 '磷酸DEA-鯨蠟酯、油醇瞇_ 20(01eth-20)、PEG-8 二硬脂酸酯、PEG-8 油酸酯、PEG- 2硬脂酸酯、聚山梨酸酯20、聚山梨酸酯60、聚山梨酸酯 80、硬脂酸丙二醇酯、月桂醇醚硫酸酯鈉（s〇diUm laureth sulfate)、倍半油酸山梨糖醇酐酯及其中任兩者或更多者 的混合物9 2根據申請專利範固第1項之組合物，進一步包含乳化劑。 3根據中請專利範圍第1項之組合物，其中DEET之含量為 ----------^-------^1.-----0 , - (請先《讀背面之注f項再填寫本貰) 本纸張尺度適用中觸蘭家捸率（CNS ) A4規格{ 公釐）Member of the Central Bureau of Procurement, Ministry of Economic Affairs, Bei Gong Xiao Cooperative Co., Ltd. printed Λ. # 'Members stated clearly whether the original suit was to be changed after the age of age 4 5 0 8 0 $ 86117553 Patent Application Chinese Manual Correction Page (88 October 2010) 5. Description of the invention (1) Introduction of the invention The present invention relates to liquid formulations containing insect repellent DEET, especially its emulsion formulations. People have used various chemicals for a long time to reduce annoying insects (such as Mosquitoes, Cangkan, Biyi, Wasps and Bees). The most widely used insect repellent currently is N, N-diethyl-m-toluidine, often called "DEET". DEET is oily, A little hygroscopic, light-sensitive oily substance has a very high dissolving power to other water-insoluble substances. Due to its shortcomings that it is not easy to emulsify, it is often made into a concentrated form or formulated as a spray or diluted solution, or a solid when used. Or semi-solid type, such as the strip type. To repel insects, people use DEET or formulations containing up to about 100% DEET on clothing and bare skin. However, 'People usually prefer the feeling of aqueous substances on the skin β in Cosmetics and medical circles have found that oily substances combined with oil-in-water emulsions are more pleasing. Since the droplets of insoluble matter are completely surrounded by water, the skin feels like an aqueous substance when used. Emulsions are also better than solution sprays and Strip-like objects are easier to apply uniformly to the skin. However, DEETs are generally not able to be made into emulsions with the stability required commercially, and it is quite undesirable to require users to mix the separated materials before using the product. SUMMARY OF THE INVENTION The present invention includes a water-repellent insect emulsion in oil containing an effective amount of N, N · diethyl, m-toluidine, water, a film-forming polymer, and an emulsifier · emulsion stabilizer. This emulsion is commercially available Accepted storage stability and the pleasant feeling when used on the skin. 1: * ^^ 1 ^ ϋ— 1 ^ 1 ^^^ 1 · ί -I ί: (Please read the precautions on the back before copying this Page) Rev. -4- 410 8 06 Patent No. 861Π553 Chinese Patent Application Request for Profits Revised Version (June 90) A8 B8 C8 D8 'Preparation, Hi Sixth Middle School, Profit, Report to the Ministry of Economic Affairs Lead Bureau of Work and Consumer Cooperatives «. 1 — Kind of drive An emulsion composition comprising: an effective insect repellent dose of N, N-diethyl-m-toluidine; water; 0.1 to 5 weight percent of a film-forming polymer selected from the group consisting of: Copolymers of octadecene and maleic acid 'copolymers of 1-trioxane and ethylene pyrrolidone, propionate / octyl acrylamide copolymer, acrylate / PVP copolymer, acrylate / Acrylamide copolymer, propionate / VA copolymer, ethylene / maleic anhydride copolymer, polyisobutylene, polyvinyl alcohol, PVp / eicosane copolymer, ammonium powder / acrylate / acrylamide Copolymer, adipic acid polymer 'and a mixture of any two or more thereof; 0.01 to 5 weight percent of an emulsifier-emulsion stabilizer, which is selected from the group consisting of: acrylate / C10- 30 Alkyl acrylate cross-linked polymers, polyisoethylene formulations, methyl vinyl fluorene / maleic anhydride copolymers, stearic acid and triethanolamine salts, and mixtures of any two or more thereof And 'optionally, 0.1 to 10 weight percent of an emulsifier selected from the group consisting of Sorbitan stearate, stearic acid, sorbitan oleate, cetyl alcohol, glyceryl oleate, glyceryl stearate 'sorbitan sesquioleate' phosphate Wax ester, oleyl alcohol 20 (01eth-20), PEG-8 distearate, PEG-8 oleate, PEG-2 stearate, polysorbate 20, polysorbate 60, Polysorbate 80, propylene glycol stearate, sodium laureth sulfate, sorbitan sesquioleate and a mixture of any two or more thereof 9 2 according to application The composition of Patent Fangu Item 1, further comprising an emulsifier. 3 The composition according to item 1 of the patent scope, wherein the content of DEET is ------------ ^ ------- ^ 1 .----- 0,-(please first "Read the note f on the back side and fill in this note) The paper size is applicable to the medium-to-blue furniture ratio (CNS) A4 specification {mm)