TW445373B - The diffuse rate polarimeter of optical active substance in solvent - Google Patents

The diffuse rate polarimeter of optical active substance in solvent Download PDF

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TW445373B
TW445373B TW87105688A TW87105688A TW445373B TW 445373 B TW445373 B TW 445373B TW 87105688 A TW87105688 A TW 87105688A TW 87105688 A TW87105688 A TW 87105688A TW 445373 B TW445373 B TW 445373B
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frequency
light
polarized
scope
signal
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Cheng Jou
Jian-Yuan Han
Wen-Jiuan Guo
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Cheng Jou
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/14558—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters by polarisation
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    • G01—MEASURING; TESTING
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    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/21—Polarisation-affecting properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6813—Specially adapted to be attached to a specific body part
    • A61B5/6814—Head
    • A61B5/6821—Eye

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Abstract

A noninvasive optical rotation angle polarimeter, which is used to investigate time varying of the optical activity of the optical active materials, such as aqueous glucose in aqueous humor of the eye is proposed. In the system, a double-frequency laser with two orthogonal linear polarized states such as Zeeman laser is used in conjunction with a polarized beam splitter (PBS), an electronic signal processor, a digital voltmeter, two photodetectors and two bandpass filters. The optical rotation angle of the optical active substance is proportional to the amplitude of the optical heterodyned signal. This system is used to continuously monitor the time varying of the optical rotation angle. The diffuse rate of the optical active substance which diffuses through semi-permeable membrane in solvent can then be determined. A common path configuration of the interferometer is set up. The capability of the immunity of the environmental disturbance is discussed.

Description

445 3 7 3 A7 B7 五、發明说明（1 ) 請 先I 33 I 讀！ 背I 面 j 之 ί 事I I | 填I If 旋光物質溶液經過;參透膜(sem^_permeable membrane );參透，其淨透速 率與兩邊的壓力有關β由於旋光物質具有旋光性（optical acdv丨ty )， 它可讓入射的線偏極化雷射光產生旋轉(optical rotation )，旋光物質 的滲透速荜可藉由線偏極化的旋轉角度隨時間鈞變化而直接量得。 另外，滲透速率的變化也因渗透膜兩端的壓力增加而造成其速率的 改變。 1-丁 本專利主要在藉由量測旋光角度的方法直接量測旋光物質溶液濃 度的變化速率而獲得滲透膜兩端的壓力差。它寸應用於動物眼睛房 水中葡萄糖（aqueous glucose)濃度變化的速'率進而即時測得房水 中壓力的大Λ；、1並印時檢查出早期造成房水壓力變化的病因，特別 是對青光眼（glaucoma )病人的早期珍斷將可提供一種高敏感度偵 測眼壓的定量方法及技術。 經濟部中央揉準局MB；工消費合作社印裝 傳統中旋光性質對線偏極化光所造成的旋光角度均藉由光起偏器 (polarizer)以及光檢偏器(analyzer)並利闬機械方式直接量取因旋光 物質所造成的旋光角度改變而得到相關的物理量，例如光折射率或 旋光物質在溶液中的濃度等β在功能上因機械的振動以及較低的量 測速度而被直接由聲光(acousto-optic)或電光(electro-optic)調變器 (modulator)產生強度調變的入射光源而取代，它藉由直接量取強度 調變的輸ά光信號的振幅或相位而求得旋光角度的大小。然而在這 些系統中利用機械方式產生強度.調變信號易受振動以及調變頻率不 南的影響而無法得到較高的量測精度，但藉由聲光，電光調變器或 光彈調變器(photoelastic modulator，ΡΕΜ)而產生高頻率的強度調變 仏號或極化光調變信號(poiarization. modulation)則因調變器本身的不 本紙法尺度適用t國闺家祿举（CNS) A4^ ( 210x297公廣） t 44537 3 λ7 __ _ B7 I " ' " " -------*_:_ 五、發明説明（2) 穩定性而造成誤差。藉由聲光調變器而產生光學外差干涉是可達到 高的調變頻率以及較高的穩定度；然而因干涉儀(mterfe「ometer)對 外界環境的干擾相當破感而造成系統量測精度上的限制。本發明係 以一組相互垂直的線偏極化雙頻穩頻雷射（例如Zeeman雷射），簡稱 雙頻穩頻雷射(two-frequency laser)為光源，利用一極化光分光片 (polarized beam splitter)或極化光析光片產生外差干涉信 號’並利用信號振幅大小量測裝置直接量取強度調變信號的振幅大 小，而獲得旋光性物質的旋轉角度(如圖一）。因faf = -之 ’丁 / 關係’溶液中旋轉角度匕與溶液中旋光物質濃度c成線性關係， 進而可藉由量測旋轉角度而得到濃度。其中△為光程，為 旋光物質之specific rotation.在光學架構上它屬於共同路徑干涉儀 (common-path interferometer)，因此系統對外界環境的干優有免疫能 力。而且構造較傳統方法簡單，同時擁有較高的量測精度及即時性。 本發明以雙頻穩頻雷射為光源，其頻率分為^與①：。調整極化光 分光片，使得X轴與入射雙頻率的相互垂直線偽極化雷射光中的P 波平行且Y軸與S波平行，如第二圖(a)。或將相互垂直之線偏極化 光分別與X軸及Y軸成一夹角，如第二圖(b)。雙頻率的相互垂 直線偏極化雷射光在通過旋光性物質後同時產生旋轉角的轉動 (如第二圖(c))。在經由極化分光片將P波與S波分開並分別由光偵 檢器DP與Ds所偵測。其所輸出的外差干涉信號可分別表示如下：445 3 7 3 A7 B7 V. Description of the invention (1) Please read I 33 I first! Back I and j of the matter II | Fill in I If the optically active substance solution passes through; see through membrane (sem ^ _permeable membrane); see through, its net permeation rate is related to the pressure on both sides β because optically active matter has optical acdv 丨 ty It can make the incident linearly polarized laser light rotate (optical rotation), and the penetration speed of the optically polarized material can be directly measured by the change of the rotation angle of the linearly polarized material with time. In addition, the change in the permeation rate is also caused by the increase in pressure at both ends of the permeation membrane. 1-D This patent mainly measures the rate of change of the concentration of the optically active substance solution directly by measuring the angle of optically active rotation to obtain the pressure difference across the membrane. It is applied to the rate of change in the concentration of aqueous glucose in the eye of an animal, and the instantaneous measurement of the large Λ of the pressure in the aqueous humor; and 1 to check the cause of the early change in aqueous humor pressure, especially for glaucoma. (Glaucoma) Early diagnosis of patients will provide a highly sensitive quantitative method and technology for detecting intraocular pressure. The Central Bureau of the Ministry of Economic Affairs, MB; the industrial and consumer cooperatives printed traditional polarized light to the polarized light caused by the polarized light (polarizer) and the optical analyzer (analyzer). The method directly measures the change of the optical rotation angle caused by the optically active substance and obtains the relevant physical quantities. For example, the optical refractive index or the concentration of the optically active substance in the solution, etc. β is directly functionally due to mechanical vibration and a low measurement speed. It is replaced by an acoustic light-optic or electro-optic modulator that generates an intensity-modulated incident light source. It directly measures the amplitude or phase of the input optical signal whose intensity is modulated. Find the magnitude of the rotation angle. However, in these systems, the strength is generated mechanically. The modulation signal is susceptible to vibration and the frequency of modulation is not high enough to obtain high measurement accuracy. However, it is modulated by acousto-optic, electro-optic, or photoelastic modulation. Photoelastic modulator (PEM) and high-frequency intensity modulation signal or poiarization. Modulation is applied due to the non-paper-based scale of the modulator itself (CNS) A4 ^ (210x297 public broadcasting) t 44537 3 λ7 __ _ B7 I " '" " ------- * _: _ 5. Explanation of the invention (2) Stability caused errors. The optical heterodyne interference generated by the acousto-optic modulator can achieve high modulation frequency and high stability; however, the system measurement is caused by the interference of the mterfe "ometer" on the external environment. Limitation on accuracy. The present invention uses a set of mutually orthogonal line-biased dual-frequency frequency-stable lasers (such as Zeeman laser), referred to as two-frequency lasers for short, as a light source, using one pole A polarized beam splitter or polarized light splitter generates a heterodyne interference signal and uses a signal amplitude measurement device to directly measure the amplitude of the intensity modulation signal to obtain the rotation angle of the optically active substance ( As shown in Figure 1), because the rotation angle of the solution in the solution of "f / =" is in a linear relationship with the concentration of the optically active substance c in the solution, the concentration can be obtained by measuring the rotation angle. Among them, △ is the optical path length, which is The specific rotation of optically active substances. It belongs to a common-path interferometer on the optical structure, so the system is immune to external interference. It is simpler to construct than traditional methods. At the same time, it has high measurement accuracy and instantaneity. The present invention uses a dual-frequency stable frequency laser as the light source, and its frequency is divided into ^ and ①: The polarized light beam splitter is adjusted so that the X-axis and the incident dual-frequency are mutually related. The P-wave in the vertical-line pseudo-polarized laser light is parallel and the Y-axis is parallel to the S-wave, as shown in the second figure (a). Or, the orthogonally-polarized linearly polarized light forms an angle with the X-axis and Y-axis, respectively, such as Second figure (b). Polarized laser light with two mutually perpendicular polarized lines passes through the optically active substance and simultaneously generates a rotation of the rotation angle (as shown in the second figure (c)). The P wave and the The S waves are separated and detected by the optical detectors DP and Ds. The heterodyne interference signals output by them can be expressed as follows:

Jp (Δωί) = ax2z sin[ 2(θν +θώ)] c〇s( Δω[)+ DC............(ι).Jp (Δωί) = ax2z sin [2 (θν + θώ)] c〇s (Δω () + DC ............ (ι).

Is ( Δωί )^aia2m^^2{0(i+9m )] cos( ΑωΙ)+ DC ......(2) j 其f A是旋光物質所造成的旋轉角：孕’冬分別為兩線偽極先的 振幅大小：=q —必，.；/X7為直流項° 當碇光性物f所造成的旋轉角度很小，Eq. (i)和Eq. (2)可改寫為：j I八Δω〇 二 la也十 认Λ①DC .................(3) 本纸杀尺度適用尹国®家揉準（CVS ) A4说格ί 210X297公釐） (诗先閱讀背面之注意事項再填写太f 訂 1 ------—線，-- 經濟部尹央標筚局員工消費合作社印裝 44537 3 A 7 ____B7_____, 五、發明説明（i ) Is (Αωΐ) = ~^axa2 {^+9m)c〇s(Δωί)+ DC ..................(4) 藉由帶通遽波器濾出強度調變信號（中心頻率設定在△£〇 )，再利 用光電信號處理器將與/5相減而得到 Ι{Δω〇 = IP~ Is= 43l22 {eQ+9m)cos(Δωί)...............(5) 我們可由振幅量測裝置量測該信號振幅大小。根據Eq.(5)，當光束 通過無旋光性物質時，所得信號振幅大小為，當光束通過旋 光性物質時，則輸出信號振幅大小為+D ^本專利之極 化光分光片（PBS)可以一極化角(azimuth angle)為之極化光析光片 (analyzer)取代，（如第三圖）所輸出外差干涉信號可表示為Is (Δωί) ^ aia2m ^^ 2 {0 (i + 9m)] cos (ΑωΙ) + DC ...... (2) j where f A is the rotation angle caused by the optically active substance: pregnant and winter are respectively The amplitude of the two-wire pseudo pole first: = q —must,.; / X7 is the DC term ° When the rotation angle caused by the photoluminescence object f is small, Eq. (I) and Eq. (2) can be rewritten as : J I eight Δω〇 two la also recognize Λ①DC ....... (3) The paper killing scale is applicable to Yin Guo® Home Kneading Standard (CVS) A4. 210X297 mm) (Read the notes on the back of the poem first and then fill in too f. Order 1 -------- line,-printed by Yinyang Biaoju Bureau of the Ministry of Economic Affairs Consumer Cooperatives 44537 3 A 7 ____B7_____, V. Description of the invention ( i) Is (Αωΐ) = ~ ^ axa2 {^ + 9m) c〇s (Δωί) + DC ........ (4) by bandpass chirp The filter filters out the intensity modulation signal (the center frequency is set to △ £ 〇), and then subtracts / 5 with the photoelectric signal processor to obtain Ι {Δω〇 = IP ~ Is = 43l22 {eQ + 9m) cos (Δωί) ......... (5) The amplitude of the signal can be measured by the amplitude measuring device. According to Eq. (5), when the light beam passes through the non-optical material, the amplitude of the obtained signal is: when the light beam passes through the optically active substance, the output signal amplitude is + D ^ Polarized light beam splitter (PBS) of this patent It can be replaced by a polarization light analyzer (azimuth angle), and the heterodyne interference signal (as shown in the third picture) can be expressed as

Ιχ (Δωί) = 2axa2 sin(cos( Δωί)+ DC ...............(6) 當旋光角恨小時，Eq (6)可寫成 Ι^Δωΐ)^ laya2 (<90 + ^)cos(Δωΐ)^ DC.....................(7) 由振幅量測裝置測量信號振幅大小為 2响（θ0 +D ....................：..............................⑻ «I (請先M讀背面之注意事項再填寫太頁> • y- 經濟部中央標牮局貝工消f合作社印裝 將Θ設定為1° *且當旋光物質濃度為零時"振幅大小可表示為 /〇 = ^3^2 ...............................................................(9) 以為零;農度校正之用β利用振幅量測裝置連續測量外差干涉信號大 小隨時間的變化量為 \ΑΙ(Δωί)\ = j/, = ^az9m =\h\-〇m..........(10) 或 .....................................(11) 由於旋轉角度與濃度的線性關係，可即時量測旋光性物質在溶液 ； 中濃度的時間變化及滲透速率。 本發明特徵說明如下：第一圖為本發明之光學組件配置a系統中所 使用的光源為一線偏極化雙頻率穩頻雷射光(10)，其中兩線偏極化 光相互垂直(Orthogonal) ’經分光片（20)將雷射光分成兩束光，一束為： 參考光束，另一束為信號光束。參考光束經過一固定方位角的極化 光析光片（ana丨yzer) Ar (45)，再經由一抉速頻荜反應的光儐檢器(55) ----千-----------Γ_____ 本.紙孩又度逋月tSli家標孪（G\S ) A4規·格（210X297公釐） V Λ4537 3 A7 五、發明説明（斗） 接收，並產生外差干涉信號9在光偵檢器(55)的後面設置一帶通濾 波為(65)並將過渡之電子信號輸入振幅量測裝置(7〇p帶通濾波器 (請先閲請背面之注意事項再填寫本頁) if) 1中〜頻率設定等於雙頻率雷射光的差頻頻率 ω —ω2)。同時當雙頻率穩頻且相互垂直的線偏極化信號光 束雷射光通過待測旋紐物質Ρ〇)後，因旋光物質本身具有旋光性： 而使通過之光束其線偏極化方向改變纥角度。極化光分光片的乂軸 與入射雷射光的Ρ波平行，γ軸與s波平行（如第二圖⑷）。極化 先分光片（40)產生外差干涉信號，分別由光偵檢器(4丨)及(43)接收’ 再經過帶通濾波器(42)，(44)直接輸出到光電信號處理裝置⑽，而得 到/()(』6>ί)外差干涉信號，並直接輸入到振幅量測裝置(7〇)中讀取 固疋拍頻率Δω外差干涉信號振幅大小，而即時量測被測試旋光物 質溶液旋轉角的時間變化及澡透速率。在第_圖中，參考外差干涉 信號輸入振幅量測裝置(70)直接量取參考光束的振幅大小，可做= 铪射光源強度後;化的監控及校正之用。第一圖中可將參考外差干; 信號做為以鎖相放大器(lock in amplifier)為振幅量測裝置的參考光 信號，而直接量取外差干涉信號的振幅大小。_______Ιχ (Δωί) = 2axa2 sin (cos (Δωί) + DC ............... (6) When the rotation angle is small, Eq (6) can be written as ^^ Δωΐ) ^ laya2 (< 90 + ^) cos (Δωΐ) ^ DC .............. (7) The amplitude of the signal measured by the amplitude measuring device is 2 ( θ0 + D .....: ............................ .... ⑻ «I (Please read the precautions on the back before filling in the page> • y- Printed by the Central Bureau of Standards, Ministry of Economic Affairs, Bei Gong Xiao Cooperative, and set Θ to 1 ° * and when the concentration of optically active substances When it is zero " the amplitude can be expressed as / 〇 = ^ 3 ^ 2 ............. .............. (9) As zero; for the correction of agronomy, β uses the amplitude measurement device to continuously measure the outside The change of the magnitude of the difference interference signal with time is \ ΑΙ (Δωί) \ = j /, = ^ az9m = \ h \ -〇m .... (10) or ... ......... (11) Due to the linear relationship between the rotation angle and the concentration, the optically active substance can be measured immediately The time variation of the concentration in solution and the permeation rate. The features of the present invention are described as follows: The first figure is the position of the optical component configuration a system of the present invention. The light source used is a linearly polarized dual-frequency stable frequency laser light (10), where the two linearly polarized lights are perpendicular to each other (Orthogonal) 'The laser light is divided into two beams by a beam splitter (20), one beam is: Reference Light beam, the other is a signal beam. The reference beam passes through a polarized light analyzer (ana 丨 yzer) Ar (45) with a fixed azimuth angle, and then passes through a photodetector (55)- --- Thousands ----------- Γ _____ Ben. The paper child spends another month tSli family standard twin (G \ S) A4 rule · Grid (210X297 mm) V Λ4537 3 A7 V. Description of the invention (Doo) Receive and generate heterodyne interference signal 9 Set a band-pass filter to (65) behind the optical detector (55) and input the transitional electronic signal to the amplitude measurement device (70p band-pass filter ( Please read the notes on the back before filling in this page) if) 1 ~~ The frequency setting is equal to the difference frequency ω —ω2 of the dual-frequency laser light. At the same time, when the dual-frequency is stable and perpendicular to each other, the linearly polarized signal beams After the laser light passes through the spin button substance P0), the optically polarized substance itself has optical rotation: the polarization direction of the passing beam is changed by the angleThe chirp axis of the polarized beam splitter is parallel to the P wave of the incident laser light, and the gamma axis is parallel to the s wave (see the second figure ⑷). The polarization first beam splitter (40) generates heterodyne interference signals, which are received by the optical detectors (4 丨) and (43), respectively, and then output directly to the photoelectric signal processing device through a band-pass filter (42), (44). ⑽, to obtain / () (『6 > ί) heterodyne interference signal, and directly input it to the amplitude measurement device (7〇) to read the fixed beat frequency Δω heterodyne interference signal amplitude, and the instant measurement is The time change of the rotation angle of the optically active substance solution and the bath penetration rate were measured. In the figure _, the reference heterodyne interference signal is input to the amplitude measurement device (70) to directly measure the amplitude of the reference beam, which can be used for monitoring and correction after the intensity of the radioactive light source. In the first figure, the reference heterodyne can be used; the signal is used as a reference optical signal with a lock in amplifier as the amplitude measurement device, and the amplitude of the heterodyne interference signal is directly measured. _______

ί. I i. ϋ丨 經濟部中央標準局員工消費合作社印製 /知沒(¾. i - iD^ ^^ 本紙張尺度適用中國國家標準（CNS) A4規格（210X297公釐） d45373 C9 D9 圖式 第一圖本發明之光學組件流程圖(I) 10-線偏極化雙頻穩頻雷射(linearpolarized two-frequency 丨aser) 2〇·分光鏡(beam splitter) J 〇 · % 先性物質(optical ac five material) 極化光分光片（polarized beam splitter PBS) 41. 光偵檢器 D (photo detector) 43.元{貞檢器 Ds (photo detector) 42. 帶通;慮波器(bandpass filter) .帶通渡波器(bandpass filter) $5,極化光析光片八細咖挪） 元電信號處理器(signal processor) 5).光 貞檢器 Dr (photo detector) 65. f 通渡波器(bandpass filter) 7〇-振幅量測裝置(voltmeter or lock in amplifier) 肌個人電猫(personal computer) 第三圖本發明之光學組件流程圖(Π) 10.線偏極化雙頻穩頻雪射(Ihear polarized two-frequency laser) 20.分光鏡(beam splitter) 〕〇旋光性物質(optical active material) 4〇.極化光析光片（analyzer) 42.帶通;慮波器(bandpass fiter) 經濟部中央標準局员工消費合作社印製 45-極化光析光片Ar (analyzer) 55.光痛檢器 £)r (photo detector) 65-帶通;慮波器(bandpass filter) 70.振幅量測裝置(voltmeter or 丨ock in amplifier) 80.個人電腦(personai compUter) 本紙張尺度適用中國國家榡準（CNS ) M規格{ 21〇χ29"7公釐） 圖式 第四圖旋光物質溶液滲透速率'測量儀 10.線偏極化雙頻穩頻雪射(linear ρο丨arized two-frequency laser) 2 0.分光鏡(beam splitter) 30.反身于鏡(mirror) 40. 極化光分光片（polarized beam splitter, PBS) 41. 光伯檢器 Dp(photo detector) 43. 光偵檢器 Ds (photo detector) 42. 帶通滤波器(bandpass filter) 44. 帶通濾波器(bandpass filter)· 45. 極化光析光片（analyzer) 50.光電信號處理器(signal processor) 55.光偵、檢器(photo detector) 6 5.帶通遽波器(bandpass filter) 70.振幅量測裝置(voltmeter or lock in amplifier) 80.個人電腦(persona丨 computer) 介電子開關(electronic shutter) 100.眼球(human eye) 110.透鏡(lens) 120.圖形顯示版 經濟部中央標準局負工消費合作社印装 (a) 極化光分光片之X軸與入射雷射光P波平行，Y軸與S波行。 (b) 極化光分光片之X軸和Y軸分別與入射雷射光P波和S波成一 Θ 〇夾角a (c)入射雷射光中P波和S波經過旋光物質並旋轉θ ηι角度。 本纸張尺度適用中國國家標準（CNS ) A4见格（2】0><297公釐）ί. I i. ϋ 丨 Printed by the Consumer Cooperatives of the Central Bureau of Standards of the Ministry of Economic Affairs / Cognizance (¾. i-iD ^ ^^ This paper size applies to the Chinese National Standard (CNS) A4 specification (210X297 mm) d45373 C9 D9 Figure The first diagram of the formula (I) 10-linearly polarized two-frequency 丨 aser 2．Beam splitter J ％ (optical ac five material) polarized beam splitter PBS 41. light detector 43 (photo detector) 43. Yuan {Chasser Ds (photo detector) 42. Bandpass; wave filter (bandpass filter) .bandpass filter ($ 5, polarized light analysis sheet), signal processor (signal processor) 5), photo detector 65 (f detector) (bandpass filter) 70-amplitude measuring device (voltmeter or lock in amplifier) muscle personal electric cat (personal computer) Figure 3 Optical component flow chart of the present invention (Π) 10. Linear polarization dual frequency stabilization frequency snow (Ihear polarized two-frequency laser) 20. Beam splitter 〔〇 Optical act (optical act ive material) 4〇. Polarized light analyzer (analyzer) 42. Bandpass; waveband (bandpass fiter) Printed 45-polarized light analyzer Ar (analyzer) 55 Photodetector £) r (photo detector) 65-bandpass; bandpass filter 70. Amplitude measuring device (voltmeter or 丨 ock in amplifier) 80. Personal computer (personai compUter) China National Standard (CNS) M specification {21〇χ29 " 7 mm) The fourth diagram of the optical rotation solution's permeation rate 'measuring instrument 10. Linear polarized dual-frequency stable frequency snow injection (linear ρο 丨 arized two- frequency laser) 2 0. beam splitter 30. mirror 40. polarized beam splitter (PBS) 41. optical detector Dp (photo detector) 43. light detection Ds (photo detector) 42. Bandpass filter (bandpass filter) 44. Bandpass filter (bandpass filter) 45. Polarized light analyzer (analyzer) 50. Photoelectric signal processor (signal processor) 55. Photo detector 6 5. Bandpass filter 70. Amplitude measuring device (voltmeter or loc k in amplifier) 80. personala computer electronic shutter 100. human eye 110 lens 120. Graphic display version Printed by the Consumers ’Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs a) The X-axis of the polarized beam splitter is parallel to the P-wave of the incident laser light, and the Y-axis is parallel to the S-wave. (b) The X-axis and Y-axis of the polarized light beam splitter form an included angle a with the incident laser light P wave and S wave, respectively. (c) The P wave and S wave in the incident laser light pass through the optically active substance and rotate through the angle of θ ηι. This paper size is applicable to Chinese National Standard (CNS) A4 (2) > < 297 mm

Claims (1)

% 445373 Αδ Β8 C8 D8 經濟部中央標準局貝工消費合作社印製 六、申請專利範圍（-） (一)一種旋光物質溶液滲透速率測量儀(如第一圖），本發明主要包 含 w —線偏極化雙頻率雪射其輸出兩種不同光頻率以及相互垂 直(orthogonal)線偏極化避^Η:。 W —組極化光分光片：位於上，可使兩'相互垂直線偏極化 光在極化光分光片之後產生外差干涉$ w兩組快速頻率反應之光偵檢器置於極Iflij光片之後，用以偵 測外差干涉信號及心以及兩組以雪射光輸出雙頻率之差 頻(Δώ?=呌-fi?2)為中心頻率之帶通濾波器 ⑷在光偵測器之後，可輸出以差頻振盪頻率之外^干涉信號， 輸入到光電信號處理裝置^J：‘ ， W —組光電信號處理裝置，金^^匕光分光片之後，可將兩組 外差干涉信號/P及加以處理&士 w —振幅量呵裝置直接量取外差干凑赛號振幅大小及其時間 變化量.1:1 / ⑷一個人將外差千涉信號振幅大小轉換成旋光角度及濃 度。 f二）如申請專利範圍第一項所記載之旋光物質溶液滲透速率測量 儀，其中線偏極化雙頻率穩頻雷射可用雙頻Zeeman穩頻氬氖雷 射，其中輸出兩相互垂直之線偏極化光且以雙光頻率輸出。 (三）如申請專利範圍第二項所記載之旋光物質溶液滲透速率測量 儀，其中線偏極化雙頻穩頻雷射可用線偏極化雙頻穩頻，固体半 導體雷射(laserdiode)，其中輸出兩線偏極化光相互^直。 (田）如申請專利範圍第二項所記載旋光物質溶液滲透速率測量 ί二線雙頻穩頻雷射可由-組單—頻率穩頻之線偏化光 广射，一組極化光分光器，及兩組不同驅勤頻率之相位 (phase modulator)組成。 又。 專利範圍第二項所記載旋光物質溶液參透速率測量儀其 化雙歸€雷射可由單—頻率線偏極化半導體射，好乂 極化光學組利用半導體雷射經由電流調變 «如申清專利範圍第-項所記載旋光物質溶液渗透速率^儀，其 t纸浪尺度適用中國國家揉準（CNS ) Α4说格（Ίϊ^_297公着） (請先閱讀背面之注意事項再填寫本頁) -訂： 3 7 3 5 4 d ABCD 、申請專利範国 中旋光物質溶液可為動物或人體眼球内房水(aqueous humor)直接 測量房水中葡萄糠旋光角度進而測量房水中葡萄糖血糖濃度及時 間變化》 f七）如申請專利範圍苐一項所記載旋光物質溶液滲透速率測量儀， 其中極化光分光片可使用光纖式極化光分光器。 f八）如申請專利範圍第一項所記載旋光物質溶液參透速率測量儀， 其中極化光分光片可使用立方體極化分光鏡(cube polarized beam splitter)。 f九）如申請專利範圍第一項所記載旋光物質溶液滲透速率測量儀， 其中極化光分光片可使用薄膜式極化分光片3 V (十）如申請專利範圍第一項所記載旋光物質溶液滲透速率測量儀， 其令極化光分光片可使用極化光析光片（analyZer)(如第三圓»Ί 統中所使用的光源為一線偏極化雙頻率穩頻雷射光(1〇)，真;本藏 線偏極化光相互垂直(orthogonal經分光片（2⑺將雷射光分成兩 束光，一束為參考光束，另一束為信號光束^雷射光通過極化光 析光片（40)，再經由一快速頻率反應的光債檢嚭(41)接收，並產 香外差干涉信！^在:光偵檢器(41)的後面設置一帶通濾波器(42) 芒將過濾之電子信號輸入振幅量測裝置(7〇)3參考光束經過一固 定方位角的極化光析光片（analyzer) Ar(45)，再舉由·及一快速頻率 反，的光偵檢器(55)接收，並產生外差干涉信號偵檢器(55) 的後面碼置遵帶通濾波器(65)並將過濾之電子信，备輸入振幅量 測裝置(70)/讀通濾波器(42)及(65)的中心頻率設定等於雙頻率雷 射光的差率(Δω = β?- ' 、、 經濟部中央揉率局男工消費合作社印製 (請先M讀背面之注意事項算填寫方頁) f十如奢專利範圍第一項所記載旋光物質溶液滲透速率測量 振幅量測裝置可使賴位式純大小測量儀 (十^如Γί，範圍第—項所記載旋光物質溶液渗透速树量 二iJT振幅量測裝置可使用鎖相放大器(1〇“ ^ ii 纸法人及用 ABCD 44537 3 、申請專利範圍ο 為雷射光源光強度的監控以便隨時校正輸出信號大小。 (請先W讀背面之注意事項再填窝本頁) (十申請專利範圍第一項所記載旋光物質溶液举透速率測量儀 ί第一圊）’其中線偏極化雙頻穩頻雪射光可經由分光片卩〇)將 :ί f由/\化光析光片（45)，光读檢器(55)，以及帶通遽 j (6 ；5)所產生的參考外差干涉信號送入振幅 鎖相放大器之參考信號。、 V ； 利範圍第一項所記載旋光物質溶液漆透速率測量 儀，其，，決达頻率反應光偵檢器可使用光二極体 (十ί如ί請專利範圍第一項所記載旋光物質溶液滲透速率 儀’其中快速頻率反應光偵檢器可使用光電放大管？11〇吣 multiplier, PMT) » (十請專利範圍第一項所記載旋光物質溶液滲透速率測量 儀’^中可通;慮·波器中心頻率設定至入射雷射光源令雙頻率之差 婷 i^at frequency ζΐω 一ω2)。 、 (十八)如申請專利範圍第一項所記載旋光物質溶液滲透速季測量 儀，其中光電信號處理裝置輸出的信號可將外差干涉信號心及 Is相藏（Ip - is、。 (十it)如申請專利範圍第一項所記載旋光物質溶液滲透速率測量 儀，其中光電信號處理裝置輸出的信號可使得外差干涉信號" 及A的平方和開根號+/j)。 經濟部t央揉隼局貝工消费合作社印衮 (二十）如申請專利範圍第一項所記載旋光物質溶液滲透速率測量 儀，其中雷射光波長可連讀採用不同波長之光源，藉以量測旋光 角度對應不同波長的關係a ί二十一j如申請專利範圍第一項所記載旋光物質溶液滲透速率測量 ^，其中雷射光波長可連續採用不同波長之光源，藉由鎖相放大 1§量測輸出之外差干涉信號與參考光外差干涉信號振幅大小的 比值(ratio) ’藉以量測旋光物質的吸收係數對應與波長的關係^ : ，予f人体，球内房水中葡萄糖的旋光特性以直接量取房永之. 旋光，度的時間變化。如第四圖，其中線偏極化雙頻率穩頻雷射 光γ經由電子開闢(9〇)，分光片（2〇)將入射雷射光分光，其令信號 光束經反射面鏡(30)以側面方向入射到人体眼球(⑴〇)並通過角 本纸乐又度通用中國囷家標丰（CNS ) ( 2I0X2?7公着） A8 B8 C8 D8 六、申請專利範圍（¢7 膜(Cornea)及房水(aqueous humor)由眼球另—側面輪岀，再通過‘ 極化光分光片（40)，將雷射光分別送入光偵檢器(41)，（43)中並產 生兩組外差干涉信號，再經過以」ω為中心頻率的帶通濾波器 (42)，（44)送入光電信號處理裝置，將外差干涉信號/^及/^相 減，再輸入气號振幅量測裝置(7〇)中直接量取振悸大小隨時間變 化的關兔f而郎時求得眼球内房水中葡萄糖濃度隨時間的變化以 及人体血糖濃度的祀g會光片（20)將入射雷射光分光產生參考光 束’它經過極化光(45)，光偵檢器(55)及帶通濾光器(65) 輸入到振幅量測裝置(70)申可隨時監控及校正入射雪射光強度 變化’或作為鎖相放大器之參考信號，第五圖中，人体眼球可藉 由透鏡組(110)及圖形顯示板(120)使眼球'因凝視圖形而固定以達 到量測人体眼球中房水葡萄糖濃度的時間變化及滲透速率。 (請先閱讀背面之注意事項再填窝本頁) 經濟部中央揉準局員工消费合作社印製 本纸張尺度逋用中國因家卷準（CNS ) A4说格（210X297公釐）% 445373 Αδ Β8 C8 D8 Printed by the Shellfish Consumer Cooperative of the Central Standards Bureau of the Ministry of Economic Affairs 6. Scope of patent application (-) (1) A measuring device for the rate of optical material penetration rate (such as the first picture), the present invention mainly includes w-line Polarized dual-frequency snow emission avoids the output of two different optical frequencies and mutually orthogonal (orthogonal) line polarization. W — group polarized light beam splitter: located on top, can make two 'mutually perpendicular line polarized light produce heterodyne interference after polarized light beam splitter $ w Two sets of fast frequency response light detectors are placed at the pole Iflij After the light sheet, it is used to detect the heterodyne interference signal and the heart, and two sets of band-pass filters centered on the difference frequency of the dual-frequency snow light output (Δώ? = 呌 -fi? 2). After that, the interference signal outside the difference frequency oscillation frequency can be output and input to the photoelectric signal processing device ^ J: ', W — group photoelectric signal processing device, after the gold light beam splitter, the two groups of heterodyne can be interfered Signal / P and its processing & ww-amplitude measurement device directly measures the amplitude of the heterodyne signal and its time variation. 1: 1 / ⑷One person converts the amplitude of the heterodyne signal into the angle of rotation And concentration. f) As described in the first patent application scope of the optically active substance solution penetration rate measuring instrument, the linearly polarized dual-frequency stabilized frequency laser can be a dual-frequency Zeeman stabilized frequency argon-neon laser, in which two mutually perpendicular lines are output Polarized light and output at two light frequencies. (3) As described in the second range of the scope of the patent application, the optically polarized material solution permeation rate measuring instrument, wherein the linearly polarized dual-frequency stable frequency laser can be linearly polarized dual-frequency stable frequency laser, solid semiconductor laser (laserdiode), Two lines of polarized light are output to each other. (Tian) As described in the second item of the scope of the patent application, the measurement of the permeation rate of the optically active substance solution. The two-line dual-frequency frequency-stabilizing laser can be wide-polarized light with a single-frequency-stable line, and a set of polarized light beam splitters. And two sets of phase modulators with different driving frequencies. also. The patented scope of the second item described in the scope of the optically active substance solution permeation rate measuring instrument is dual-homed. The laser can be irradiated with a single-frequency-line polarized semiconductor. Fortunately, the polarization optics group uses the semiconductor laser to modulate the current through a semiconductor laser. The scope of the patented item No.-the permeation rate solution of the optically active substance, the t paper wave scale is applicable to the Chinese National Standard (CNS) Α4 said grid (Ίϊ ^ _297) (Please read the precautions on the back before filling this page )-Order: 3 7 3 5 4 d ABCD, patent application Fan Guozhong Optically active substance solution can directly measure the angle of rotation of grape bran in aqueous humor in animals or human eyeballs to measure the glucose and blood glucose concentration and time change in aqueous humor 》 FVII) As described in the scope of application for a patent (1), the polarizing light beam splitter can use a polarized light beam splitter. f) As described in the first item of the scope of the patent application, the permeation rate measuring device of the optically active substance solution, wherein a polarized beam splitter can be a cube polarized beam splitter. fIX) As described in the first scope of the patent application, the polarized light spectrometer can use a thin film polarizing beam splitter 3 V (10) The optically active substance described in the first scope of the patent application Solution penetration rate measuring instrument, which allows polarized light beamsplitters to use polarized light analyzer (analyZer) (such as the light source used in the third circle »system is a linearly polarized dual-frequency stable frequency laser light (1 〇), true; the polarized polarized lights of this Tibetan line are perpendicular to each other (orthogonal via a beam splitter (2⑺ splits the laser light into two light beams, one beam is a reference beam and the other beam is a signal beam ^ laser light is decomposed by polarized light) (40), and then receive it through a fast frequency response optical debt detector (41), and produce a fragrant heterodyne interference letter! ^ A band pass filter (42) is installed behind the light detector (41) The filtered electronic signal is input to the amplitude measuring device (70). The reference beam passes through a polarized light analyzer (Ar) (45) with a fixed azimuth angle, and then a light detection by a fast frequency inversion is provided. The detector (55) receives and generates a heterodyne interference signal. The filter (65) and the filtered electronic message are input to the amplitude measurement device (70) / read-through filter (42) and (65). The center frequency is set equal to the difference of the dual-frequency laser light (Δω = β? -'、 Printed by the Male Workers Consumer Cooperatives of the Central Rubbing Bureau of the Ministry of Economic Affairs (please read the notes on the back and fill in the page first) The device can be used in a position-type pure size measuring instrument (ten ^ such as Γί, the range of the first item of the optically active substance solution permeation speed tree quantity iJT amplitude measurement device can use a phase-locked amplifier (1〇 "^ ii paper company and use ABCD 44537 3. Scope of patent application ο To monitor the light intensity of the laser light source so that the output signal can be corrected at any time. (Please read the precautions on the back before filling in this page) (10 The optically active substance described in the first item of the scope of the patent application Solution lift-through rate measuring instrument ί The first 其中) 'Where the linearly polarized dual-frequency stable frequency snow light can be transmitted through the spectroscope 卩 〇) will be: ί f // chemical light analysis sheet (45), optical reader (55), and the reference heterodyne produced by the bandpass 遽 j (6; 5) The reference signal sent to the amplitude-locked amplifier is a reference signal. V, The range of the optically active substance solution paint rate measurement device described in the first item of the scope of interest, the photodetector can use the photodiode (ten) As described in the first item of the patent scope, the optically active substance solution permeation rate meter 'of which a fast frequency response optical detector can use a photo-amplifier tube? 11〇 吣 multiplier, PMT) » The material solution permeation rate measuring instrument can be passed; the center frequency of the wave device is set to the incident laser light source so that the difference between the two frequencies (i ^ at frequency ζΐω-ω2). (18) As described in the first item of the scope of the patent application, the polarimetric solution permeation speed season measuring instrument, wherein the signal output by the photoelectric signal processing device can hide the heterodyne interference signal center and Is (Ip-is ,. it) As described in the first item of the scope of the patent application, the optical material solution permeation rate measuring instrument, wherein the signal output by the photoelectric signal processing device can make the heterodyne interference signal " and the square root of the A + / j). Seal of the Ministry of Economic Affairs of the Central Government Bureau of Bayong Consumer Cooperative (20) As described in the first scope of the patent application scope, the optical material solution penetration rate measuring instrument, in which the wavelength of the laser light can be read continuously using light sources with different wavelengths for measurement The relationship of the rotation angle to different wavelengths a. Twenty-onej. As described in the first patent application, the measurement of the penetration rate of the solution of the optical rotation substance ^, where the laser light wavelength can continuously use light sources with different wavelengths, and the amount of phase-locked amplification is 1 § Measure the ratio of the amplitude of the output heterodyne interference signal to the amplitude of the reference optical heterodyne interference signal (ratio) 'to measure the relationship between the absorption coefficient of the optically active substance and the wavelength. Direct measurement of Fang Yongzhi. Optical rotation, degree of time change. As shown in the fourth figure, the linearly polarized dual-frequency stable frequency laser light γ is developed by the electron (90), and the beam splitter (20) splits the incident laser light, which causes the signal beam to pass through the reflecting mirror (30) to the side. Into the human eyeball (⑴〇) in the direction, and through the corner paper music, once again GM China Standard Label (CNS) (2I0X2? 7) A8 B8 C8 D8 VI. Patent Application Scope (¢ 7 Film (Cornea) and Aqueous humor is from the other side of the eyeball to the side, and then the laser light is sent to the light detectors (41) and (43) through the polarized light beam splitter (40), and two sets of heterodyne are generated. The interference signal is sent to the photoelectric signal processing device through a band-pass filter (42) and (44) centered at ω, and the heterodyne interference signals / ^ and / ^ are subtracted, and the gas signal amplitude measurement is input. The device (70) directly measures the time-dependent value of the oscillating size of the rabbit, and determines the time-dependent change of the glucose concentration in the aqueous humor and the blood glucose concentration of the human body (20). Spectral light generates a reference beam 'which passes through polarized light (45), light detector (55) and bandpass filter (65) to the amplitude The measuring device (70) can monitor and correct the change in the intensity of the incident snow light at any time 'or as a reference signal of the lock-in amplifier. In the fifth figure, the human eyeball can make the eyeball through the lens group (110) and the graphic display board (120). 'Fixed due to the shape of the fixed view to measure the temporal change and penetration rate of the aqueous glucose concentration in the human eyeball. (Please read the precautions on the back before filling in this page.) Printed by the Consumers Cooperative of the Central Bureau of the Ministry of Economic Affairs Paper size using China In-House Volume Standard (CNS) A4 grid (210X297 mm)
TW87105688A 1998-04-15 1998-04-15 The diffuse rate polarimeter of optical active substance in solvent TW445373B (en)

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US9442065B2 (en) 2014-09-29 2016-09-13 Zyomed Corp. Systems and methods for synthesis of zyotons for use in collision computing for noninvasive blood glucose and other measurements
US9448165B2 (en) 2014-09-29 2016-09-20 Zyomed Corp. Systems and methods for control of illumination or radiation collection for blood glucose and other analyte detection and measurement using collision computing
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