TW349950B - Substituted tetracyclic azepine derivatives - Google Patents

Substituted tetracyclic azepine derivatives

Info

Publication number
TW349950B
TW349950B TW084111063A TW84111063A TW349950B TW 349950 B TW349950 B TW 349950B TW 084111063 A TW084111063 A TW 084111063A TW 84111063 A TW84111063 A TW 84111063A TW 349950 B TW349950 B TW 349950B
Authority
TW
Taiwan
Prior art keywords
hydrogen
alkyl
6alkyl
independently
taken together
Prior art date
Application number
TW084111063A
Other languages
Chinese (zh)
Inventor
Victor K Sipido
Francisco J Fernandez-Gadea
Jose I Andres-Gii
Theo F Meert
Pilar Gil-Lopetegui
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Application granted granted Critical
Publication of TW349950B publication Critical patent/TW349950B/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/20—Dibenz [b, e] azepines; Hydrogenated dibenz [b, e] azepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, ***e
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Abstract

A compound of formula (I), the pharmaceutically salts and stereoisomeric forms thereof, and also the N-oxide forms thereof, wherein R1 and R2 each independently are hydrogen; C1-6 alkyl; C1-6 alkylcarbonyl; trihalomethylcarbonyl; C1-6 alkyl substituted with hydroxy, C1-6 alkyloxy, carboxyl, C1-6 alkylcarbonyloxy, C1-6 alkyloxycaronyl or aryl; or R1 and R2 taken together with the nitrogen atom to which they are attached may form a morpholinyl ring or an optionally substituted heterocycle, wherein m is 1, 2 or 3; R19, R20, R21 and R22 each independently are hydrogen or C1-6alkyl; or R21and R22 taken together form a divalent C 4-5 alkyl-di(group); R23 is hydrogen; C1-6 alkyl, trihaloemthylcarbonyl; aryl; di(aryl)methyl; R3, R4, R5, R6, R9, R10, R11 or R12 each independently are hydrogen, halo, cyano, hydroxy, trifluoromethyl, trifluoromethoxy, carboxyl, nitro, amino, mono- or di(C1-6 alkyl)-amino, C1-6 alkylcarbonylamino, C1-6 alkyl, C 1-6 alkyloxy; R7 and R8 are each independently hydrogen, hydroxy, C1-6alkyl, C1-6alkyloxy or R7 and R8 taken together may form mono- or di(cyano)methylene, or together with the carbon atom to which they are attached form a carbonyl ro a spiro substituent; or R7 and R8 taken together may form methylene; R13 is hydrogen, C1-6alkyl, or trifluoromethyl; R14 is hydrogen, C1-6alkyl, cyano, or trifluoromethyl; n is zero to 6; aryl group is phenyl or halo-substituted phenyl.
TW084111063A 1994-11-02 1995-10-20 Substituted tetracyclic azepine derivatives TW349950B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP94203178 1994-11-02
US08/457,968 US5552399A (en) 1994-11-02 1995-05-31 Substituted tetracyclic azepine derivatives

Publications (1)

Publication Number Publication Date
TW349950B true TW349950B (en) 1999-01-11

Family

ID=8217337

Family Applications (1)

Application Number Title Priority Date Filing Date
TW084111063A TW349950B (en) 1994-11-02 1995-10-20 Substituted tetracyclic azepine derivatives

Country Status (30)

Country Link
US (1) US5552399A (en)
EP (1) EP0789701B1 (en)
JP (1) JP3818541B2 (en)
KR (1) KR100392060B1 (en)
CN (1) CN1085667C (en)
AR (1) AR002238A1 (en)
AT (1) ATE199087T1 (en)
AU (1) AU704285B2 (en)
BR (1) BR9509552A (en)
CA (1) CA2203661A1 (en)
CZ (1) CZ286945B6 (en)
DE (1) DE69520070T2 (en)
DK (1) DK0789701T3 (en)
ES (1) ES2155898T3 (en)
FI (1) FI113050B (en)
GR (1) GR3035680T3 (en)
HR (1) HRP950537A2 (en)
HU (1) HUT77408A (en)
IL (1) IL115819A (en)
MY (1) MY113325A (en)
NO (1) NO308035B1 (en)
NZ (1) NZ295656A (en)
PL (1) PL183686B1 (en)
PT (1) PT789701E (en)
RU (1) RU2163240C2 (en)
SI (1) SI0789701T1 (en)
TR (1) TR199501356A2 (en)
TW (1) TW349950B (en)
WO (1) WO1996014320A1 (en)
ZA (1) ZA959215B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0892804T3 (en) * 1996-04-12 2002-12-02 Janssen Pharmaceutica Nv Isoxazolidine derivatives
UA52778C2 (en) * 1997-10-10 2003-01-15 Янссен Фармацевтика Н.В. Tetrahydrofurane halogen substituted tetracyclic derivatives, a process for production and compositions on basis thereof
HRP20020305A8 (en) 2002-04-10 2009-03-31 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. 2-thia-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof
HRP20030885A2 (en) * 2003-11-03 2005-08-31 Pliva-Istra�iva�ki institut d.o.o. USE OF 2-THIA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYYTEM DISEASES AND DISORDERS
HRP20030953A2 (en) * 2003-11-21 2005-10-31 Pliva-Istra�iva�ki institut d.o.o. PREPARATION OF 1-AZA-2-OXA-DIBENZO[e,h]AZULENES AND THEIR USE FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
JP2020526592A (en) * 2017-07-13 2020-08-31 トニックス ファーマシューティカルズ ホールディング コーポレーション Cyclobenzaprine analogs and amitryptylene analogs

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT338799B (en) * 1974-03-02 1977-09-12 Boehringer Sohn Ingelheim PROCESS FOR PREPARING NEW SUBSTITUTED 6-ARYL-4H-S-TRIAZOLO- (3,4C) -THIENO- (2,3E) -1,4-DIAZEPINE AND THEIR SALTS
NL7414038A (en) * 1974-10-28 1976-05-03 Akzo Nv NEW TETRACYCLIC PYRROLIDINO DERIVATIVES.
DE2647114A1 (en) * 1975-10-21 1977-05-05 Hans Fickler Linear motion drive from rotary motor - has drums of different dia. to produce high load without reduction gear
JPS5572177A (en) * 1978-11-27 1980-05-30 Shionogi & Co Ltd 4,1-benzoxazepine or 4,1-benzothiazepine
CA2026925A1 (en) * 1989-10-05 1991-04-06 Hiroshi Fukumi Tetracyclic compounds having anti-allergic and anti-asthmatic activities, their preparation and use
US5512563A (en) * 1993-07-29 1996-04-30 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists

Also Published As

Publication number Publication date
DE69520070T2 (en) 2001-09-13
AU3924995A (en) 1996-05-31
CN1162313A (en) 1997-10-15
NO972017D0 (en) 1997-04-30
RU2163240C2 (en) 2001-02-20
JPH10508308A (en) 1998-08-18
HUT77408A (en) 1998-04-28
NO308035B1 (en) 2000-07-10
PT789701E (en) 2001-07-31
FI113050B (en) 2004-02-27
BR9509552A (en) 1997-09-16
CZ286945B6 (en) 2000-08-16
FI971854A0 (en) 1997-04-30
PL183686B1 (en) 2002-06-28
GR3035680T3 (en) 2001-06-29
PL319939A1 (en) 1997-09-01
AR002238A1 (en) 1998-03-11
SI0789701T1 (en) 2001-08-31
US5552399A (en) 1996-09-03
NO972017L (en) 1997-04-30
EP0789701A1 (en) 1997-08-20
IL115819A (en) 1998-10-30
ATE199087T1 (en) 2001-02-15
KR100392060B1 (en) 2003-11-28
NZ295656A (en) 1998-10-28
ES2155898T3 (en) 2001-06-01
IL115819A0 (en) 1996-01-19
FI971854A (en) 1997-04-30
WO1996014320A1 (en) 1996-05-17
DK0789701T3 (en) 2001-06-18
AU704285B2 (en) 1999-04-15
ZA959215B (en) 1997-04-30
CZ132397A3 (en) 1998-01-14
CA2203661A1 (en) 1996-05-17
TR199501356A2 (en) 1996-06-21
JP3818541B2 (en) 2006-09-06
HRP950537A2 (en) 1997-08-31
MX9703255A (en) 1997-07-31
DE69520070D1 (en) 2001-03-15
CN1085667C (en) 2002-05-29
EP0789701B1 (en) 2001-02-07
MY113325A (en) 2002-01-31

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