TW275060B - - Google Patents

Info

Publication number: TW275060B
Authority: TW; Taiwan
Prior art keywords: group; carbon atoms; production; hydrocarbon radical; hydrogen atom
Prior art date: 1991-12-13

Application number

TW082100181A

Other languages

English (en)

Inventor

Wiesinger Herbert

Haberey Martin

Original Assignee

Schering Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-12-13

Filing date

1993-01-13

Publication date

1996-05-01

1993-01-13 Application filed by Schering Ag filed Critical Schering Ag

1996-05-01 Application granted granted Critical

1996-05-01 Publication of TW275060B publication Critical patent/TW275060B/zh

Links

125000004432 carbon atom Chemical group C* 0.000 abstract 3
239000004215 Carbon black (E152) Substances 0.000 abstract 2
229930195733 hydrocarbon Natural products 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
125000004423 acyloxy group Chemical group 0.000 abstract 1
125000003277 amino group Chemical group 0.000 abstract 1
125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
125000001231 benzoyloxy group Chemical group C(C1=CC=CC=C1)(=O)O* 0.000 abstract 1
235000020964 calcitriol Nutrition 0.000 abstract 1
239000011612 calcitriol Substances 0.000 abstract 1
GMRQFYUYWCNGIN-NKMMMXOESA-N calcitriol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C GMRQFYUYWCNGIN-NKMMMXOESA-N 0.000 abstract 1
229960005084 calcitriol Drugs 0.000 abstract 1
125000002837 carbocyclic group Chemical group 0.000 abstract 1
230000024245 cell differentiation Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
230000006698 induction Effects 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
125000004043 oxo group Chemical group O=* 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
239000008177 pharmaceutical agent Substances 0.000 abstract 1
229920006395 saturated elastomer Polymers 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1
239000011593 sulfur Substances 0.000 abstract 1
150000003710 vitamin D derivatives Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Hematology (AREA)
Obesity (AREA)
Diabetes (AREA)
Rheumatology (AREA)
Endocrinology (AREA)
Oncology (AREA)
Immunology (AREA)
Nutrition Science (AREA)
Dermatology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

TW082100181A 1991-12-13 1993-01-13 TW275060B (zh)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE4141746A DE4141746A1 (de)	1991-12-13	1991-12-13	20-methyl-substituierte vitamin d-derivate

Publications (1)

Publication Number	Publication Date
TW275060B true TW275060B (zh)	1996-05-01

Family

ID=6447341

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TW082100181A TW275060B (zh)	1991-12-13	1993-01-13

Country Status (24)

Country	Link
US (1)	US5446035A (zh)
EP (1)	EP0637299B1 (zh)
JP (1)	JP3280975B2 (zh)
KR (1)	KR100271462B1 (zh)
CN (1)	CN1035177C (zh)
AT (1)	ATE138366T1 (zh)
AU (1)	AU670585B2 (zh)
CA (1)	CA2125476C (zh)
CZ (1)	CZ286579B6 (zh)
DE (2)	DE4141746A1 (zh)
DK (1)	DK0637299T3 (zh)
ES (1)	ES2089585T3 (zh)
FI (1)	FI108226B (zh)
GR (1)	GR3020097T3 (zh)
HU (1)	HUT68263A (zh)
IL (1)	IL104074A (zh)
MX (1)	MX9207101A (zh)
NO (1)	NO305949B1 (zh)
NZ (1)	NZ246052A (zh)
PL (1)	PL171403B1 (zh)
SK (1)	SK280450B6 (zh)
TW (1)	TW275060B (zh)
WO (1)	WO1993012081A1 (zh)
ZA (1)	ZA929650B (zh)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4220757A1 (de) *	1992-06-24	1994-01-05	Schering Ag	Derivate in der Vitamin D-Reihe mit Modifikationen in der 20-Position, Verfahren zu ihrer Herstellung, Zwischenprodukte für dieses Verfahren, diese Derivate enthaltende pharmazeutische Präparate sowie deren Verwendung zur Herstellung von Arzneimitteln
GB9220272D0 (en) *	1992-09-25	1992-11-11	Leo Pharm Prod Ltd	Chemical compounds
IL107185A (en) *	1992-10-06	1998-02-22	Schering Ag	History of 52-carboxylic acid, processes for their preparation and pharmaceutical preparations containing them
US6407082B1 (en) *	1996-09-13	2002-06-18	New Life Pharmaceuticals Inc.	Prevention of ovarian cancer by administration of a vitamin D compound
US20040167106A1 (en) *	1993-06-04	2004-08-26	Rodriguez Gustavo C.	Prevention of ovarian cancer by administration of a Vitamin D compound
GB9315253D0 (en) *	1993-07-23	1993-09-08	Res Inst Medicine Chem	Chemical compounds
US5428029A (en) *	1993-11-24	1995-06-27	Hoffmann-La Roche Inc.	Vitamin D3 fluorinated analogs
US5981597A (en) *	1995-02-13	1999-11-09	Trustees Of The University Of Pennsylvania	Differentiating agents for the treatment of inflammatory intestinal diseases
WO1997029775A1 (en) *	1996-02-13	1997-08-21	G.D. Searle & Co.	Compositions comprising a cyclooxygenase-2 inhibitor and a leukotriene b4 receptor antagonist
DE19619036A1 (de)	1996-04-30	1997-11-13	Schering Ag	Neue Vitamin D-Derivate mit carbo- oder heterocyclischen Substituenten an C-25, Verfahren zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln
SG70010A1 (en) *	1996-05-23	2000-01-25	Hoffmann La Roche	Fluorinated vitamin d3 analogs
US6511970B1 (en)	1996-09-13	2003-01-28	New Life Pharmaceuticals Inc.	Prevention of ovarian cancer by administration of products that induce transforming growth factor-beta and/or apoptosis in the ovarian epithelium
US6034074A (en)	1996-09-13	2000-03-07	New Life Pharmaceuticals Inc.	Prevention of ovarian cancer by administration of a Vitamin D compound
US6028064A (en)	1996-09-13	2000-02-22	New Life Pharmaceuticals Inc.	Prevention of ovarian cancer by administration of progestin products
US6765002B2 (en)	2000-03-21	2004-07-20	Gustavo Rodriguez	Prevention of ovarian cancer by administration of products that induce transforming growth factor-β and/or apoptosis in the ovarian epithelium
JP4219553B2 (ja) *	1997-09-08	2009-02-04	エフ．ホフマン−ラロシュアーゲー	１，３−ジヒドロキシ−２０，２０−ジアルキル−ビタミンｄ３類似体
EP2340840B1 (en)	1998-03-27	2012-08-29	Oregon Health Sciences University	Pulse dose Vitamin D drug for the treatment of hyperproliferative skin diseases
US20030188756A1 (en) *	2002-08-19	2003-10-09	Cantorna Margherita T	Treatment of inflammatory bowel disease with vitamin d compounds
US6358939B1 (en)	1999-12-21	2002-03-19	Northern Lights Pharmaceuticals, Llc	Use of biologically active vitamin D compounds for the prevention and treatment of inflammatory bowel disease
US6989377B2 (en)	1999-12-21	2006-01-24	Wisconsin Alumni Research Foundation	Treating vitamin D responsive diseases
US20010044431A1 (en) *	2000-03-21	2001-11-22	Rodriguez Gustavo C.	Prevention of ovarian cancer by administration of products that induce biologic effects in the ovarian epithelium
AU2001278744A1 (en) *	2000-08-17	2002-02-25	Chugai Seiyaku Kabushiki Kaisha	Remedial agent for osteoporosis
TWI329105B (en) *	2002-02-01	2010-08-21	Rigel Pharmaceuticals Inc	2,4-pyrimidinediamine compounds and their uses
KR20120062863A (ko) *	2003-07-30	2012-06-14	리겔 파마슈티칼스, 인크.	자가면역 질환의 치료 또는 예방에 사용하기 위한 2,4-피리미딘디아민 화합물
EP1879449A4 (en) *	2005-05-10	2009-12-16	Dermipsor Ltd	SKIN CARE COMPOSITIONS AND METHODS
EP1879595B1 (en) *	2005-05-10	2014-09-24	Dermipsor Ltd	Compositions and methods for treating hyperproliferative epidermal diseases
WO2006135915A2 (en)	2005-06-13	2006-12-21	Rigel Pharmaceuticals, Inc.	Methods and compositions for treating degenerative bone disorders
DE602005000514T2 (de) *	2005-06-17	2007-10-25	Magneti Marelli Powertrain S.P.A.	Brennstoffeinspritzventil
DE602007012216D1 (de) *	2006-04-10	2011-03-10	Wisconsin Alumni Res Found	1-alpha-hydroxy-2-(3'-hydroxypropyliden)-19-nor-vitamin-d-verbindungen mit einer 1,1-dimethylpropyl-seitenkette
US20080051380A1 (en) *	2006-08-25	2008-02-28	Auerbach Alan H	Methods and compositions for treating cancer
KR20090060306A (ko)	2006-08-25	2009-06-11	코우가 바이오테크놀로지, 인크.	비타민 ｄ 화합물 및 추가 치료제, 및 그를 함유하는 조성물을 투여하는 것을 포함하는, 암을 치료하는 방법
US20080051375A1 (en) *	2006-08-25	2008-02-28	Auerbach Alan H	Methods for treating cancer comprising the administration of a vitamin d compound and an additional therapeutic agent, and compositions containing the same
WO2009009132A1 (en) *	2007-07-12	2009-01-15	Cougar Biotechnology, Inc.	Use of 17alpha-hydroxylase/c17, 20-lyase inhibitors for the treatment of cancer
CN102341110B (zh) *	2009-01-27	2017-04-12	博格有限责任公司	用于减轻与化疗有关的副作用的维生素d3及其类似物
SG10201404883YA (en)	2009-08-14	2014-10-30	Berg Llc	Vitamin d3 and analogs thereof for treating alopecia
WO2017209934A1 (en)	2016-05-13	2017-12-07	Case Western Reserve University	Autophagy activators for treating or preventing skin injury
CN109640991A (zh)	2016-07-29	2019-04-16	詹森药业有限公司	治疗***癌的方法
US10548908B2 (en)	2016-09-15	2020-02-04	Nostopharma, LLC	Compositions and methods for preventing and treating heterotopic ossification and pathologic calcification
US11903952B2 (en)	2020-05-27	2024-02-20	Northwestern University	Vitamin D as an immune modulator to prevent immune-related complication from COVID-19 infection

1991
- 1991-12-13 DE DE4141746A patent/DE4141746A1/de not_active Withdrawn
1992
- 1992-12-08 MX MX9207101A patent/MX9207101A/es not_active IP Right Cessation
- 1992-12-11 ZA ZA929650A patent/ZA929650B/xx unknown
- 1992-12-12 CN CN92114249A patent/CN1035177C/zh not_active Expired - Fee Related
- 1992-12-13 IL IL104074A patent/IL104074A/en not_active IP Right Cessation
- 1992-12-14 EP EP92924724A patent/EP0637299B1/de not_active Expired - Lifetime
- 1992-12-14 KR KR1019940702001A patent/KR100271462B1/ko not_active IP Right Cessation
- 1992-12-14 CA CA002125476A patent/CA2125476C/en not_active Expired - Fee Related
- 1992-12-14 DK DK92924724.5T patent/DK0637299T3/da active
- 1992-12-14 ES ES92924724T patent/ES2089585T3/es not_active Expired - Lifetime
- 1992-12-14 AU AU40356/93A patent/AU670585B2/en not_active Ceased
- 1992-12-14 HU HU9401456A patent/HUT68263A/hu unknown
- 1992-12-14 WO PCT/EP1992/002887 patent/WO1993012081A1/de active IP Right Grant
- 1992-12-14 JP JP51062193A patent/JP3280975B2/ja not_active Expired - Fee Related
- 1992-12-14 SK SK661-94A patent/SK280450B6/sk unknown
- 1992-12-14 AT AT92924724T patent/ATE138366T1/de not_active IP Right Cessation
- 1992-12-14 NZ NZ246052A patent/NZ246052A/xx unknown
- 1992-12-14 DE DE59206393T patent/DE59206393D1/de not_active Expired - Lifetime
- 1992-12-14 PL PL92304142A patent/PL171403B1/pl not_active IP Right Cessation
- 1992-12-14 CZ CZ19941416A patent/CZ286579B6/cs not_active IP Right Cessation
1993
- 1993-01-13 TW TW082100181A patent/TW275060B/zh active
1994
- 1994-06-10 NO NO942178A patent/NO305949B1/no unknown
- 1994-06-10 FI FI942766A patent/FI108226B/fi not_active IP Right Cessation
- 1994-09-16 US US08/307,081 patent/US5446035A/en not_active Expired - Fee Related
1996
- 1996-05-30 GR GR960401459T patent/GR3020097T3/el unknown

Also Published As

Publication number	Publication date
GR3020097T3 (en)	1996-08-31
IL104074A (en)	1998-01-04
CZ141694A3 (en)	1995-01-18
CZ286579B6 (cs)	2000-05-17
EP0637299B1 (de)	1996-05-22
FI942766A (fi)	1994-06-10
CA2125476C (en)	2003-02-11
NO305949B1 (no)	1999-08-23
IL104074A0 (en)	1993-05-13
US5446035A (en)	1995-08-29
CA2125476A1 (en)	1993-06-24
DE59206393D1 (de)	1996-06-27
PL171403B1 (pl)	1997-04-30
AU670585B2 (en)	1996-07-25
KR100271462B1 (ko)	2000-11-15
FI942766A0 (fi)	1994-06-10
SK280450B6 (sk)	2000-02-14
ATE138366T1 (de)	1996-06-15
NO942178D0 (no)	1994-06-10
DE4141746A1 (de)	1993-06-17
MX9207101A (es)	1993-08-01
CN1073677A (zh)	1993-06-30
SK66194A3 (en)	1995-02-08
AU4035693A (en)	1993-07-19
ZA929650B (en)	1993-06-09
JP3280975B2 (ja)	2002-05-13
DK0637299T3 (da)	1996-09-30
FI108226B (fi)	2001-12-14
ES2089585T3 (es)	1996-10-01
KR940703806A (ko)	1994-12-12
EP0637299A1 (de)	1995-02-08
NO942178L (zh)	1994-06-10
NZ246052A (en)	1995-07-26
HU9401456D0 (en)	1994-08-29
WO1993012081A1 (de)	1993-06-24
HUT68263A (en)	1995-06-28
CN1035177C (zh)	1997-06-18
JPH07505132A (ja)	1995-06-08

Publication	Publication Date	Title
TW275060B (zh)	1996-05-01
HK116296A (en)	1996-07-12	Amide derivatives and dermatologic preparations containing the same
DE3664909D1 (en)	1989-09-14	Vitamin d3 derivatives
ZA858169B (en)	1986-06-25	New adamantanamine derivatives,processes for their preparation and drugs in which they are present
ES2126581T3 (es)	1999-04-01	Derivados de 3-(piperazino-alquil)indol condensados en posiciones 1,7, asi como procedimiento y productos intermedios para su preparacion y medicamentos que contienen estos compuestos.
DE69415812D1 (de)	1999-03-18	15,15-dialkylsubstituierte östradiolderivate
IL64614A (en)	1985-06-30	6alpha-methylhydrocortisone derivatives,processes for their preparation and pharmaceutical compositions containing them
HUT37935A (en)	1986-03-28	Process for production of 3-alkoxi-2-n-pirrolidin-n-piridil-n-furil /or n-tienil/-methil-prophil amins
TW252976B (zh)	1995-08-01
HUT35658A (en)	1985-07-29	Process for producing 7-oxo-prostacycline derivatives of selective biological activity
GB1416929A (en)	1975-12-10	Fluoranthene derivatives
ES8200703A1 (es)	1981-12-01	Procedimiento para la preparacion de 1-hidroxi-esteroides
SI0746556T1 (en)	2003-02-28	Tricyclic compounds having affinity for the 5-ht1a receptor
ES2085544T3 (es)	1996-06-01	Procedimiento para la fabricacion de 8-n,n-dialquilaminotriciclo-(5.2.1.02,6)decano.
ES2059702T3 (es)	1994-11-16	Politioureas, procedimiento para su fabricacion y empleo de estas politioureas para evitar o reducir la formacion de costras en reactores.