TW265345B - - Google Patents

Info

Publication number
TW265345B
TW265345B TW083101358A TW83101358A TW265345B TW 265345 B TW265345 B TW 265345B TW 083101358 A TW083101358 A TW 083101358A TW 83101358 A TW83101358 A TW 83101358A TW 265345 B TW265345 B TW 265345B
Authority
TW
Taiwan
Prior art keywords
alkyl
ccl2
phosphonates
opt
r4choh
Prior art date
Application number
TW083101358A
Other languages
English (en)
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Application granted granted Critical
Publication of TW265345B publication Critical patent/TW265345B/zh

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40Esters thereof
    • C07F9/4003Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4015Esters of acyclic unsaturated acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3808Acyclic saturated acids which can have further substituents on alkyl
    • C07F9/3821Acyclic saturated acids which can have further substituents on alkyl substituted by B, Si, P or a metal
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3826Acyclic unsaturated acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40Esters thereof
    • C07F9/4003Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006Esters of acyclic acids which can have further substituents on alkyl
    • C07F9/4012Esters of acyclic acids which can have further substituents on alkyl substituted by B, Si, P or a metal

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
TW083101358A 1993-02-23 1994-02-18 TW265345B (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2141193A 1993-02-23 1993-02-23

Publications (1)

Publication Number Publication Date
TW265345B true TW265345B (zh) 1995-12-11

Family

ID=21804071

Family Applications (1)

Application Number Title Priority Date Filing Date
TW083101358A TW265345B (zh) 1993-02-23 1994-02-18

Country Status (19)

Country Link
US (1) US5463181A (zh)
EP (1) EP0686159B1 (zh)
JP (1) JPH08509470A (zh)
KR (1) KR100305128B1 (zh)
CN (1) CN1045207C (zh)
AT (1) ATE159023T1 (zh)
AU (1) AU684071B2 (zh)
CA (1) CA2154871C (zh)
DE (1) DE69406110T2 (zh)
DK (1) DK0686159T3 (zh)
ES (1) ES2110738T3 (zh)
FI (1) FI111369B (zh)
GR (1) GR3025499T3 (zh)
HU (1) HUT72647A (zh)
IL (1) IL108694A0 (zh)
NO (1) NO306618B1 (zh)
NZ (1) NZ262585A (zh)
TW (1) TW265345B (zh)
ZA (1) ZA941099B (zh)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1554572B1 (en) 2001-07-25 2009-10-14 Raptor Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
FR2833266B1 (fr) * 2001-12-11 2004-10-22 Mayoly Spindler Lab Nouveaux derives phosphonates, leur procede de preparation, leur utilisation comme modulateurs de l'activite des lymphocytes tgamma9 delta2
EP3827747A1 (en) 2005-04-28 2021-06-02 Otsuka Pharmaceutical Co., Ltd. Pharma-informatics system
EP2063905B1 (en) 2006-09-18 2014-07-30 Raptor Pharmaceutical Inc Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates
NZ616673A (en) 2009-02-20 2014-08-29 To Bbb Holding B V Glutathione-based drug delivery system
ES2942923T3 (es) 2009-05-06 2023-06-07 Laboratory Skin Care Inc Composiciones de administración dérmica que comprenden complejos de agente activo-partículas de fosfato de calcio y métodos de uso de las mismas
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57142993A (en) * 1981-02-28 1982-09-03 Sagami Chem Res Center 2-hydroxyphosphonic diester
DE3313070A1 (de) * 1983-04-12 1984-10-18 Bayer Ag, 5090 Leverkusen Chlorierte phosphorylmethylcarbonyl-derivate, verfahren zu ihrer herstellung und ihre verwendung in pflanzenschutmitteln
DE3425701A1 (de) * 1984-07-12 1986-01-16 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von chlorierten phosphorylmethylcarbonyl-derivaten und neue zwischenprodukte zu ihrer herstellung
US4924024A (en) * 1988-01-11 1990-05-08 E. R. Squibb & Sons, Inc. Phosphorus-containing squalene synthetase inhibitors, new intermediates and method
US5177239A (en) * 1989-07-18 1993-01-05 E. R. Squibb & Sons, Inc. Method for preparing a phosphonic acid ester
US5298655A (en) * 1991-09-27 1994-03-29 Merck & Co., Inc. Farnesyl pyrophosphate analogs

Also Published As

Publication number Publication date
ES2110738T3 (es) 1998-02-16
CN1045207C (zh) 1999-09-22
FI111369B (fi) 2003-07-15
DE69406110T2 (de) 1998-05-14
NO953292D0 (no) 1995-08-22
DK0686159T3 (da) 1998-01-26
HUT72647A (en) 1996-05-28
EP0686159A1 (en) 1995-12-13
ATE159023T1 (de) 1997-10-15
KR100305128B1 (ko) 2001-11-22
DE69406110D1 (de) 1997-11-13
HU9502455D0 (en) 1995-10-30
GR3025499T3 (en) 1998-02-27
CA2154871C (en) 1998-04-07
ZA941099B (en) 1994-08-30
FI953934A0 (fi) 1995-08-22
US5463181A (en) 1995-10-31
FI953934A (fi) 1995-08-22
NO953292L (no) 1995-08-22
AU6232494A (en) 1994-09-14
CN1118166A (zh) 1996-03-06
CA2154871A1 (en) 1994-09-01
IL108694A0 (en) 1994-05-30
NZ262585A (en) 1997-12-19
AU684071B2 (en) 1997-12-04
EP0686159B1 (en) 1997-10-08
JPH08509470A (ja) 1996-10-08
NO306618B1 (no) 1999-11-29

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