TW226991B - - Google Patents

Info

Publication number: TW226991B
Authority: TW; Taiwan
Prior art keywords: halogen atom; symbol; preparation; new; radicals
Prior art date: 1991-05-17

Application number

TW081103793A

Other languages

English (en)

Original Assignee

Rhone Poulenc Rorer Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-05-17

Filing date

1992-05-15

Publication date

1994-07-21

1992-05-15 Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa

1994-07-21 Application granted granted Critical

1994-07-21 Publication of TW226991B publication Critical patent/TW226991B/zh

Links

125000005843 halogen group Chemical group 0.000 abstract 3
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
QDZOEBFLNHCSSF-PFFBOGFISA-N (2S)-2-[[(2R)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-1-[(2R)-2-amino-5-carbamimidamidopentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-N-[(2R)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]pentanediamide Chemical compound C([C@@H](C(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)NC(=O)[C@@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](N)CCCNC(N)=N)C1=CC=CC=C1 QDZOEBFLNHCSSF-PFFBOGFISA-N 0.000 abstract 1
ODSNARDHJFFSRH-UHFFFAOYSA-N 2,3,3a,4,5,6,7,7a-octahydro-1h-isoindole Chemical class C1CCCC2CNCC21 ODSNARDHJFFSRH-UHFFFAOYSA-N 0.000 abstract 1
102100024304 Protachykinin-1 Human genes 0.000 abstract 1
101800003906 Substance P Proteins 0.000 abstract 1
239000005557 antagonist Substances 0.000 abstract 1
TUJKJAMUKRIRHC-UHFFFAOYSA-N hydroxyl Chemical group [OH] TUJKJAMUKRIRHC-UHFFFAOYSA-N 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical compound [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
-1 phenyl radicals Chemical class 0.000 abstract 1
150000003254 radicals Chemical class 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles

TW081103793A 1991-05-17 1992-05-15 TW226991B (zh)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9106036A FR2676443B1 (fr)	1991-05-17	1991-05-17	Nouveaux derives de perhydroisoindole et leur preparation.

Publications (1)

Publication Number	Publication Date
TW226991B true TW226991B (zh)	1994-07-21

Family

ID=9412908

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TW081103793A TW226991B (zh)	1991-05-17	1992-05-15

Country Status (23)

Country	Link
US (1)	US5508433A (zh)
EP (2)	EP0514274A1 (zh)
JP (1)	JPH06507628A (zh)
AT (1)	ATE116295T1 (zh)
AU (1)	AU1884092A (zh)
CA (1)	CA2109297A1 (zh)
CZ (1)	CZ244893A3 (zh)
DE (1)	DE69201058T2 (zh)
DK (1)	DK0586471T3 (zh)
ES (1)	ES2066620T3 (zh)
FI (1)	FI935072A (zh)
FR (1)	FR2676443B1 (zh)
HU (1)	HUT68913A (zh)
IE (1)	IE921579A1 (zh)
IL (1)	IL101867A0 (zh)
MX (1)	MX9202288A (zh)
NO (1)	NO933976D0 (zh)
NZ (1)	NZ242773A (zh)
SK (1)	SK126893A3 (zh)
TW (1)	TW226991B (zh)
WO (1)	WO1992020654A1 (zh)
YU (1)	YU51692A (zh)
ZA (1)	ZA923541B (zh)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
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FR2676442B1 (fr) *	1991-05-17	1993-08-06	Rhone Poulenc Rorer Sa	Nouveau derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent.
FR2689889B1 (fr) *	1992-04-10	1994-06-10	Rhone Poulenc Rorer Sa	Nouveaux derives de perhydroisoindole, et leur preparation.
US5508424A (en) *	1993-03-26	1996-04-16	Ortho Pharmaceutical Corporation	4-arylisoindole analgesics
FR2703679B1 (fr) *	1993-04-05	1995-06-23	Rhone Poulenc Rorer Sa	Nouveaux derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent.
TW365603B (en) *	1993-07-30	1999-08-01	Rhone Poulenc Rorer Sa	Novel perhydroisoindole derivatives, their preparation and pharmaceutical compositions which contain them
FR2710913B1 (fr) *	1993-10-07	1995-11-24	Rhone Poulenc Rorer Sa	Nouveaux dérivés de perhydroisoindole, leur préparation et les compositions pharmaceutiques qui les contiennent.
FR2709752B1 (fr) *	1993-07-30	1995-10-06	Rhone Poulenc Rorer Sa	Nouveaux dérivés de perhydroisoindole, leur préparation et les compositions pharmaceutiques qui les contiennent.
FR2728165A1 (fr)	1994-12-19	1996-06-21	Oreal	Utilisation d'un antagoniste de substance p pour le traitement des rougeurs cutanees d'origine neurogene
FR2728169A1 (fr)	1994-12-19	1996-06-21	Oreal	Utilisation d'un antagoniste de substance p pour le traitement des prurits et des dysesthesies oculaires ou palpebrales
FR2728166A1 (fr)	1994-12-19	1996-06-21	Oreal	Composition topique contenant un antagoniste de substance p
FR2741262B1 (fr)	1995-11-20	1999-03-05	Oreal	Utilisation d'un antagoniste de tnf-alpha pour le traitement des rougeurs cutanees d'origine neurogene
DK1246806T3 (da)	1999-11-03	2008-06-16	Amr Technology Inc	Aryl- og heteroarylsubstituerede tetrahydroisoquinoliner og anvendelse deraf til blokering af genoptagelse af norepinefrin, dopsmin og serotonin
US7163949B1 (en)	1999-11-03	2007-01-16	Amr Technology, Inc.	4-phenyl substituted tetrahydroisoquinolines and use thereof
BR0112350A (pt)	2000-07-11	2003-06-24	Albany Molecular Res Inc	Composto, composição farmacêutica, e, método de tratar um animal afligido por um distúrbio neurológico ou psicológico
US6709651B2 (en)	2001-07-03	2004-03-23	B.M.R.A. Corporation B.V.	Treatment of substance P-related disorders
KR101412339B1 (ko)	2004-07-15	2014-06-25	알바니 몰레큘라 리써치, 인크.	아릴- 및 헤테로아릴-치환된 테트라히드로이소퀴놀린, 및이것의 노르에피네프린, 도파민 및 세로토닌의 재흡수를차단하기 위한 용도
US8362075B2 (en)	2005-05-17	2013-01-29	Merck Sharp & Dohme Corp.	Cyclohexyl sulphones for treatment of cancer
US7956050B2 (en)	2005-07-15	2011-06-07	Albany Molecular Research, Inc.	Aryl- and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
GB0603041D0 (en)	2006-02-15	2006-03-29	Angeletti P Ist Richerche Bio	Therapeutic compounds
US20110218176A1 (en)	2006-11-01	2011-09-08	Barbara Brooke Jennings-Spring	Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
PL2336120T3 (pl)	2007-01-10	2014-12-31	Msd Italia Srl	Kombinacje zawierające indazole podstawione grupą amidową jako inhibitory polimerazy poli(ADP-rybozy) (PARP)
CA2690191C (en)	2007-06-27	2015-07-28	Merck Sharp & Dohme Corp.	4-carboxybenzylamino derivatives as histone deacetylase inhibitors
US9156812B2 (en)	2008-06-04	2015-10-13	Bristol-Myers Squibb Company	Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
AR071997A1 (es)	2008-06-04	2010-07-28	Bristol Myers Squibb Co	Forma cristalina de 6-((4s)-2-metil-4-(2-naftil)-1,2,3,4-tetrahidroisoquinolin-7-il)piridazin-3-amina
WO2010114780A1 (en)	2009-04-01	2010-10-07	Merck Sharp & Dohme Corp.	Inhibitors of akt activity
WO2010132487A1 (en)	2009-05-12	2010-11-18	Bristol-Myers Squibb Company	CRYSTALLINE FORMS OF (S)-7-([1,2,4]TRIAZOLO[1,5-a]PYRIDIN-6-YL)-4-(3,4-DICHLOROHPHENYL)-1,2,3,4-TETRAHYDROISOQUINOLINE AND USE THEREOF
KR101830447B1 (ko)	2009-05-12	2018-02-20	알바니 몰레큘라 리써치, 인크.	7-(［1,2,4］트리아졸로［1,5-α］피리딘-6-일)-4-(3,4-디클로로페닐)-1,2,3,4-테트라하이드로이소퀴놀린 및 이의 용도
US9034899B2 (en)	2009-05-12	2015-05-19	Albany Molecular Research, Inc.	Aryl, heteroaryl, and heterocycle substituted tetrahydroisoquinolines and use thereof
PE20121172A1 (es)	2009-10-14	2012-09-05	Merck Sharp & Dohme	Piperidinas sustituidas con actividad en la hdm2
CA2805265A1 (en)	2010-08-02	2012-02-09	Merck Sharp & Dohme Corp.	Rna interference mediated inhibition of catenin (cadherin-associated protein), beta 1 (ctnnb1) gene expression using short interfering nucleic acid (sina)
CA2807307C (en)	2010-08-17	2021-02-09	Merck Sharp & Dohme Corp.	Rna interference mediated inhibition of hepatitis b virus (hbv) gene expression using short interfering nucleic acid (sina)
EP2608669B1 (en)	2010-08-23	2016-06-22	Merck Sharp & Dohme Corp.	NOVEL PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS
US8946216B2 (en)	2010-09-01	2015-02-03	Merck Sharp & Dohme Corp.	Indazole derivatives useful as ERK inhibitors
US9242981B2 (en)	2010-09-16	2016-01-26	Merck Sharp & Dohme Corp.	Fused pyrazole derivatives as novel ERK inhibitors
EP2632472B1 (en)	2010-10-29	2017-12-13	Sirna Therapeutics, Inc.	Rna interference mediated inhibition of gene expression using short interfering nucleic acids (sina)
US9351965B2 (en)	2010-12-21	2016-05-31	Merck Sharp & Dohme Corp.	Indazole derivatives useful as ERK inhibitors
IN2013MN02170A (zh)	2011-04-21	2015-06-12	Piramal Entpr Ltd
WO2013063214A1 (en)	2011-10-27	2013-05-02	Merck Sharp & Dohme Corp.	Novel compounds that are erk inhibitors
EP2844261B1 (en)	2012-05-02	2018-10-17	Sirna Therapeutics, Inc.	SHORT INTERFERING NUCLEIC ACID (siNA) COMPOSITIONS
WO2014052563A2 (en)	2012-09-28	2014-04-03	Merck Sharp & Dohme Corp.	Novel compounds that are erk inhibitors
MX363243B (es)	2012-11-28	2019-03-14	Merck Sharp & Dohme	Composiciones para tratar cáncer y usos de dichas composiciones.
BR112015013611A2 (pt)	2012-12-20	2017-11-14	Merck Sharp & Dohme	composto, e, composição farmacêutica
EP2951180B1 (en)	2013-01-30	2018-05-02	Merck Sharp & Dohme Corp.	2,6,7,8 substituted purines as hdm2 inhibitors
EP3041938A1 (en)	2013-09-03	2016-07-13	Moderna Therapeutics, Inc.	Circular polynucleotides
WO2019094311A1 (en)	2017-11-08	2019-05-16	Merck Sharp & Dohme Corp.	Prmt5 inhibitors
WO2020033284A1 (en)	2018-08-07	2020-02-13	Merck Sharp & Dohme Corp.	Prmt5 inhibitors
US20210277009A1 (en)	2018-08-07	2021-09-09	Merck Sharp & Dohme Corp.	Prmt5 inhibitors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4042707A (en) *	1976-02-19	1977-08-16	E. I. Du Pont De Nemours And Company	3α-Arylhydroisoindoles
AU502760B2 (en) *	1977-02-28	1979-08-09	Science Union Et Cie, Societe Francaise De Recherche Medicale	Azabicycloalkanes and their preparation
EP0093805B1 (en) *	1981-02-17	1987-05-13	Warner-Lambert Company	Octahydro-2-(omega-mercaptoalkanoyl)3-oxo-1h-isoindole-1-carboxylic acids and esters
US4439229A (en) *	1981-06-29	1984-03-27	Rohm And Haas Company	Substituted phthalimides herbicides
JPH0278659A (ja) *	1988-09-12	1990-03-19	Shionogi & Co Ltd	アザビシクロアルカン類化合物
FR2654725B1 (fr) *	1989-11-23	1992-02-14	Rhone Poulenc Sante	Nouveaux derives de l'isoindolone, leur preparation et les compositions pharmaceutiques qui les contiennent.

1991
- 1991-05-17 FR FR9106036A patent/FR2676443B1/fr not_active Expired - Lifetime
1992
- 1992-05-12 CZ CS932448A patent/CZ244893A3/cs unknown
- 1992-05-14 IL IL101867A patent/IL101867A0/xx unknown
- 1992-05-15 JP JP4510463A patent/JPH06507628A/ja active Pending
- 1992-05-15 EP EP92401330A patent/EP0514274A1/fr active Pending
- 1992-05-15 WO PCT/FR1992/000430 patent/WO1992020654A1/fr not_active Application Discontinuation
- 1992-05-15 SK SK1268-93A patent/SK126893A3/sk unknown
- 1992-05-15 ES ES92911071T patent/ES2066620T3/es not_active Expired - Lifetime
- 1992-05-15 NZ NZ242773A patent/NZ242773A/xx unknown
- 1992-05-15 AU AU18840/92A patent/AU1884092A/en not_active Abandoned
- 1992-05-15 MX MX9202288A patent/MX9202288A/es unknown
- 1992-05-15 YU YU51692A patent/YU51692A/sh unknown
- 1992-05-15 EP EP92911071A patent/EP0586471B1/fr not_active Expired - Lifetime
- 1992-05-15 DE DE69201058T patent/DE69201058T2/de not_active Expired - Fee Related
- 1992-05-15 DK DK92911071.6T patent/DK0586471T3/da active
- 1992-05-15 AT AT92911071T patent/ATE116295T1/de not_active IP Right Cessation
- 1992-05-15 TW TW081103793A patent/TW226991B/zh active
- 1992-05-15 ZA ZA923541A patent/ZA923541B/xx unknown
- 1992-05-15 HU HU9303250A patent/HUT68913A/hu unknown
- 1992-05-15 US US08/146,142 patent/US5508433A/en not_active Expired - Fee Related
- 1992-05-15 CA CA002109297A patent/CA2109297A1/fr not_active Abandoned
- 1992-07-01 IE IE157992A patent/IE921579A1/en not_active Application Discontinuation
1993
- 1993-11-03 NO NO1993933976A patent/NO933976D0/no unknown
- 1993-11-16 FI FI935072A patent/FI935072A/fi not_active Application Discontinuation

Also Published As

Publication number	Publication date
FI935072A0 (fi)	1993-11-16
IL101867A0 (en)	1992-12-30
AU1884092A (en)	1992-12-30
CZ244893A3 (en)	1994-04-13
SK126893A3 (en)	1994-11-09
EP0586471B1 (fr)	1994-12-28
NO933976L (no)	1993-11-03
ZA923541B (en)	1993-01-27
ATE116295T1 (de)	1995-01-15
NZ242773A (en)	1994-06-27
EP0514274A1 (fr)	1992-11-19
FR2676443A1 (fr)	1992-11-20
FI935072A (fi)	1993-11-16
DK0586471T3 (da)	1995-06-06
NO933976D0 (no)	1993-11-03
WO1992020654A1 (fr)	1992-11-26
DE69201058T2 (de)	1995-05-11
HUT68913A (en)	1995-08-28
IE921579A1 (en)	1992-11-18
MX9202288A (es)	1992-11-01
DE69201058D1 (de)	1995-02-09
ES2066620T3 (es)	1995-03-01
CA2109297A1 (fr)	1992-11-18
HU9303250D0 (en)	1994-03-28
US5508433A (en)	1996-04-16
YU51692A (sh)	1994-06-10
EP0586471A1 (fr)	1994-03-16
JPH06507628A (ja)	1994-09-01
FR2676443B1 (fr)	1993-08-06

Publication	Publication Date	Title
TW226991B (zh)	1994-07-21
MX9202287A (es)	1993-02-01	Nuevos derivados de perhidroisoindol, procedimiento para su preparacion y composicion farmaceutica que los contiene.
ZA909370B (en)	1991-10-30	New isoindolone derivatives and their preparation
GR3033996T3 (en)	2000-11-30	3-(Piperi-4-yl) 1,2-benzisoxazole and 3-(piperazin-4-yl) 1,2-benzisoxazole derivatives, processes for their preparation and pharmaceutical compositions containing them
DK0700914T3 (da)	2000-07-31	Campththecinderivater, deres fremstilling og antitumormidler
DE69104075D1 (de)	1994-10-27	Mesomorphe Verbindung, sie enthaltende flüssigkristalline Zusammensetzung, sie verwendende flüssigkristalline Vorrichtung und Anzeigeapparat.
GR80359B (en)	1985-01-11	Derivatives of 4-(3-alkynyloxy-2-hydroxy-propyl)-piperazin -1-yl-n-phenyl-acetamide
PL277153A1 (en)	1989-09-18	Herbicide
ES469577A1 (es)	1978-12-01	Un procedimiento para la preparacion de 5-alquil y 5-alque- nil-sulfonil-halogenpirimidinas.
RU93058289A (ru)	1996-12-27	Производные пергидроизоиндола, способы их получения