TW223637B - - Google Patents

Info

Publication number
TW223637B
TW223637B TW082100448A TW82100448A TW223637B TW 223637 B TW223637 B TW 223637B TW 082100448 A TW082100448 A TW 082100448A TW 82100448 A TW82100448 A TW 82100448A TW 223637 B TW223637 B TW 223637B
Authority
TW
Taiwan
Prior art keywords
antirheumatic
chem
iii
image
active ingredient
Prior art date
Application number
TW082100448A
Other languages
English (en)
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Application granted granted Critical
Publication of TW223637B publication Critical patent/TW223637B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
    • C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
TW082100448A 1992-01-27 1993-01-27 TW223637B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP5305192 1992-01-27
JP7510692 1992-02-13
JP10832092 1992-03-16
JP11512692 1992-03-24

Publications (1)

Publication Number Publication Date
TW223637B true TW223637B (zh) 1994-05-11

Family

ID=27462860

Family Applications (1)

Application Number Title Priority Date Filing Date
TW082100448A TW223637B (zh) 1992-01-27 1993-01-27

Country Status (10)

Country Link
US (2) US6559149B1 (zh)
EP (1) EP0632038B1 (zh)
KR (1) KR100248324B1 (zh)
AT (1) ATE204576T1 (zh)
AU (1) AU3367693A (zh)
CA (1) CA2128205C (zh)
DE (1) DE69330639T2 (zh)
ES (1) ES2161713T3 (zh)
TW (1) TW223637B (zh)
WO (1) WO1993015077A1 (zh)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100248324B1 (ko) * 1992-01-27 2000-04-01 나가야마 오사무 메토트렉세이트 유도체
ATE184605T1 (de) * 1992-12-25 1999-10-15 Chugai Pharmaceutical Co Ltd Methotrexat-derivate
WO1996030019A1 (fr) * 1995-03-27 1996-10-03 Chugai Seiyaku Kabushiki Kaisha Medicament contenant un derive de methotrexate
US7276506B2 (en) * 1998-12-28 2007-10-02 4 Aza Bioscience Nv Immunosuppressive effects of pteridine derivatives
US7229986B2 (en) * 2000-05-16 2007-06-12 Takeda Pharmaceutical Company Ltd. Melanin-concentrating hormone antagonist
US20070032477A1 (en) * 2003-10-17 2007-02-08 Waer Mark J A Pteridine derivatives useful for making pharmaceutical compositions
US20060039985A1 (en) * 2004-04-27 2006-02-23 Bennett David B Methotrexate compositions
US7601834B2 (en) * 2005-02-22 2009-10-13 Savvipharm Inc Compositions and methods of reducing side effects and toxicity of methotrexate when given as orotate derivatives
US20070123478A1 (en) 2005-11-28 2007-05-31 Rowe Vernon D Compositions useful for reducing nephrotoxicity and methods of use thereof
WO2007098089A2 (en) * 2006-02-17 2007-08-30 Novacea, Inc. Treatment of hyperproliferative diseases with methotrexate n-oxide and analogs
WO2008009079A2 (en) * 2006-07-20 2008-01-24 Gilead Sciences, Inc. Substituted pteridines useful for the treatment and prevention of viral infections
ES2707574T3 (es) 2007-04-11 2019-04-04 Merck & Cie Folatos marcados con 18F
MX2011004006A (es) 2008-11-19 2011-05-19 Pola Chem Ind Inc Agentes antiarrugas.
DK3097102T3 (en) 2015-03-04 2018-01-22 Gilead Sciences Inc TOLL-LIKE RECEPTOR MODULATING 4,6-DIAMINO-PYRIDO [3,2-D] PYRIMIDINE COMPOUNDS
US10640499B2 (en) 2016-09-02 2020-05-05 Gilead Sciences, Inc. Toll like receptor modulator compounds
MA46093A (fr) 2016-09-02 2021-05-19 Gilead Sciences Inc Composés modulateurs du recepteur de type toll
TW202210480A (zh) 2019-04-17 2022-03-16 美商基利科學股份有限公司 類鐸受體調節劑之固體形式
TW202212339A (zh) 2019-04-17 2022-04-01 美商基利科學股份有限公司 類鐸受體調節劑之固體形式
TW202115056A (zh) 2019-06-28 2021-04-16 美商基利科學股份有限公司 類鐸受體調節劑化合物的製備方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI812775L (fi) 1980-09-12 1982-03-13 Farmos Oy Foerfarande foer framstaellning av n-/4-/(2,4-diamino-6-pteridinyl)-metyl/metylamino/benzoyl/glutaminsyra och derivat daerav
US4490529A (en) * 1983-09-06 1984-12-25 Dana-Farber Cancer Institute, Inc. Cysteic acid and homocysteic acid analogues of methotrexate and aminopterin
JP3124592B2 (ja) * 1990-08-14 2001-01-15 中外製薬株式会社 新規メトトレキセート誘導体
AU8333291A (en) * 1990-08-14 1992-03-17 Chugai Seiyaku Kabushiki Kaisha Novel methotrexate derivative
JP3207285B2 (ja) * 1992-01-27 2001-09-10 中外製薬株式会社 新規メトトレキセート誘導体
KR100248324B1 (ko) * 1992-01-27 2000-04-01 나가야마 오사무 메토트렉세이트 유도체
JP3274532B2 (ja) * 1992-03-24 2002-04-15 中外製薬株式会社 抗リウマチ剤

Also Published As

Publication number Publication date
CA2128205C (en) 2004-03-30
US6559149B1 (en) 2003-05-06
EP0632038A1 (en) 1995-01-04
DE69330639D1 (de) 2001-09-27
ES2161713T3 (es) 2001-12-16
US20030171376A1 (en) 2003-09-11
CA2128205A1 (en) 1993-08-05
DE69330639T2 (de) 2002-07-04
WO1993015077A1 (en) 1993-08-05
KR100248324B1 (ko) 2000-04-01
AU3367693A (en) 1993-09-01
EP0632038B1 (en) 2001-08-22
EP0632038A4 (en) 1995-02-22
ATE204576T1 (de) 2001-09-15

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