TW218021B - - Google Patents

Info

Publication number
TW218021B
TW218021B TW081105668A TW81105668A TW218021B TW 218021 B TW218021 B TW 218021B TW 081105668 A TW081105668 A TW 081105668A TW 81105668 A TW81105668 A TW 81105668A TW 218021 B TW218021 B TW 218021B
Authority
TW
Taiwan
Prior art keywords
alkylaminocarbonyl
substituent
staplylococci
aminocarbonyl
alkoxycarbonyl
Prior art date
Application number
TW081105668A
Other languages
Chinese (zh)
Original Assignee
Lepetit Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26128958&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TW218021(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lepetit Spa filed Critical Lepetit Spa
Application granted granted Critical
Publication of TW218021B publication Critical patent/TW218021B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
    • C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Cephalosporin Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention is directed to novel antibiotic A 40926 derivatives characterized by having a carboxy, (C1-C4)alkoxycarbonyl, aminocarbonyl, (C1-C4)alkylaminocarbonyl, di(C1-C4)alkylaminocarbonyl or hydroxymethyl substituent on the N-acylaminoglucuronyl moiety and a hydroxy or a polyamine substituent in position 63 of the molecule. The compounds of the invention show high in vitro activity against glycopeptide resistant Enterococci and Staplylococci.
TW081105668A 1991-07-29 1992-07-17 TW218021B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP91112685 1991-07-29
EP92109906 1992-06-12

Publications (1)

Publication Number Publication Date
TW218021B true TW218021B (en) 1993-12-21

Family

ID=26128958

Family Applications (1)

Application Number Title Priority Date Filing Date
TW081105668A TW218021B (en) 1991-07-29 1992-07-17

Country Status (24)

Country Link
EP (2) EP0525499A1 (en)
JP (1) JP3418762B2 (en)
KR (1) KR100242682B1 (en)
AT (1) ATE125551T1 (en)
AU (1) AU666862B2 (en)
BG (1) BG61124B2 (en)
CA (1) CA2109601C (en)
CZ (1) CZ285703B6 (en)
DE (1) DE69203724T2 (en)
DK (1) DK0596929T3 (en)
ES (1) ES2075709T3 (en)
FI (1) FI112662B (en)
GR (1) GR3017897T3 (en)
HU (2) HU223946B1 (en)
IE (1) IE68420B1 (en)
IL (1) IL102623A (en)
MX (1) MX9204394A (en)
NO (1) NO314150B1 (en)
NZ (1) NZ243735A (en)
PL (1) PL171813B1 (en)
RU (1) RU2125058C1 (en)
TW (1) TW218021B (en)
UA (1) UA41283C2 (en)
WO (1) WO1993003060A1 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5606036A (en) * 1991-03-27 1997-02-25 Gruppo Lepetit Spa Antibiotic A 40926 ester derivatives
MY128335A (en) * 1994-01-28 2007-01-31 Lilly Co Eli Glycopeptide antibiotic derivatives
US5840684A (en) * 1994-01-28 1998-11-24 Eli Lilly And Company Glycopeptide antibiotic derivatives
DK0836619T3 (en) * 1995-07-05 2004-12-06 Aventis Bulk S P A Purification of dalbaheptide antibiotics by isoelectric focusing
DK0912604T3 (en) * 1996-04-23 2002-03-25 Biosearch Italia Spa Improved chemical process for the preparation of amide derivatives of A 40926 antibiotic
US6004959A (en) * 1996-05-30 1999-12-21 Hoechst Marion Roussel, Inc. Alkyloxyamino substituted fluorenones and their use as protein kinase-C inhibitors
WO2000039156A1 (en) 1998-12-23 2000-07-06 Advanced Medicine, Inc. Glycopeptide derivatives and pharmaceutical compositions containing the same
AR021964A1 (en) * 1998-12-23 2002-09-04 Theravance Inc A GLICOPEPTIDIC COMPOUND, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND USE OF SUCH GLYOPEPTIDIC COMPOUNDS FOR THE MANUFACTURE OF AN ANTIBACTERIAL MEDICINAL PRODUCT.
TWI312785B (en) 2001-08-24 2009-08-01 Theravance Inc Process for preparing vancomycin derivatives
TWI275594B (en) 2001-08-24 2007-03-11 Theravance Inc Process for preparing vancomycin phosphonate derivatives
KR100478533B1 (en) * 2002-07-30 2005-03-28 한국수력원자력 주식회사 A METHOD OF SEPARATlNG THALLIUM ISOTOPES USING LASER SYSTEM
US20060074014A1 (en) 2002-11-18 2006-04-06 Vicuron Pharmaceuticals Inc. Dalbavancin compositions for treatment of bacterial infections
EP1565201B1 (en) 2002-11-18 2018-10-31 Vicuron Pharmaceuticals, Inc. Methods of administering dalbavancin for treatment of bacterial infections
US7119061B2 (en) * 2002-11-18 2006-10-10 Vicuron Pharmaceuticals, Inc. Dalbavancin compositions for treatment of bacterial infections
EP1641480A1 (en) 2003-05-27 2006-04-05 Theravance, Inc. Use of a polyene macrolide antifungal agent in combination with a glycopeptide antibacterial agent
DE602004010915T2 (en) 2003-07-22 2008-12-11 Theravance, Inc., South San Francisco USE OF AN ANTIMYCOTIC ECHINOCANDIN AGENT COMBINED WITH AN ANTIBACTERIAL GLYCOPEPTIDE AGENT
BRPI0516657A (en) 2004-11-29 2008-09-16 Univ Nagoya Nat Univ Corp glycopeptide antibiotic monomer derivatives
TW200808818A (en) 2006-05-26 2008-02-16 Shionogi & Co Glycopeptide antibiotic derivatives
US8481696B2 (en) 2007-12-26 2013-07-09 Shionogi & Co., Ltd. Glycosylated glycopeptide antibiotic derivatives
EP4274842A1 (en) * 2021-01-11 2023-11-15 Xellia Pharmaceuticals ApS Synthesis process

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8608809D0 (en) * 1986-04-11 1986-05-14 Lepetit Spa Antibiotic
GB8726859D0 (en) * 1987-11-17 1987-12-23 Lepetit Spa 22-dechlorotei-coplanins
ES2083374T3 (en) * 1988-12-27 1996-04-16 Lepetit Spa AMIDIC DERIVATIVES IN POSITION C63 OF 34-DES (ACETILGLUCOSAMINIL) -34-DESOXI-TEICOPLANINAS.
GB2231846B (en) * 1989-05-25 1993-02-24 Hadlum Brothers Ltd A hand held carrier
EP0560795B1 (en) * 1990-12-05 1996-02-21 GRUPPO LEPETIT S.p.A. 38-decarboxy-38-hydroxymethyl derivatives of teicoplanin antibiotics, and a process for preparing them
EP0578644B1 (en) * 1991-03-27 1996-12-04 GRUPPO LEPETIT S.p.A. Antibiotic a 40926 ester derivatives

Also Published As

Publication number Publication date
IE68420B1 (en) 1996-06-12
CZ285703B6 (en) 1999-10-13
NO934722D0 (en) 1993-12-20
MX9204394A (en) 1993-01-29
BG61124B2 (en) 1996-11-29
DE69203724D1 (en) 1995-08-31
JP3418762B2 (en) 2003-06-23
CZ19294A3 (en) 1994-11-16
ES2075709T3 (en) 1995-10-01
JPH06509347A (en) 1994-10-20
UA41283C2 (en) 2001-09-17
IL102623A (en) 1996-10-16
EP0596929B1 (en) 1995-07-26
WO1993003060A1 (en) 1993-02-18
NO314150B1 (en) 2003-02-03
NO934722L (en) 1994-02-14
DE69203724T2 (en) 1996-01-18
KR100242682B1 (en) 2000-02-01
CA2109601A1 (en) 1993-02-18
AU666862B2 (en) 1996-02-29
NZ243735A (en) 1995-01-27
DK0596929T3 (en) 1995-09-11
IE922451A1 (en) 1993-02-10
HU223946B1 (en) 2005-03-29
ATE125551T1 (en) 1995-08-15
HUT66080A (en) 1994-09-28
AU2326292A (en) 1993-03-02
CA2109601C (en) 2002-07-02
PL171813B1 (en) 1997-06-30
GR3017897T3 (en) 1996-01-31
HU9400256D0 (en) 1994-05-30
FI112662B (en) 2003-12-31
EP0596929A1 (en) 1994-05-18
EP0525499A1 (en) 1993-02-03
IL102623A0 (en) 1993-01-14
RU2125058C1 (en) 1999-01-20
FI940394A (en) 1994-01-26
FI940394A0 (en) 1994-01-26
HU211347A9 (en) 1995-11-28

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Legal Events

Date Code Title Description
MM4A Annulment or lapse of patent due to non-payment of fees