TW208006B - A production method of 2-substituted methy1-2,3-dihydroimidazole[1,2,c]quinazoline-5(6H)-keto(thioxo) and its usage - Google Patents

A production method of 2-substituted methy1-2,3-dihydroimidazole[1,2,c]quinazoline-5(6H)-keto(thioxo) and its usage

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Publication number
TW208006B
TW208006B TW80107818A TW80107818A TW208006B TW 208006 B TW208006 B TW 208006B TW 80107818 A TW80107818 A TW 80107818A TW 80107818 A TW80107818 A TW 80107818A TW 208006 B TW208006 B TW 208006B
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TW
Taiwan
Prior art keywords
alkyl
phenyl
hydrogen
substituted
groups
Prior art date
Application number
TW80107818A
Other languages
Chinese (zh)
Inventor
Ji-Wang Chen
Jia-Yang Shiau
Maw-Shyong Yan
Guann-Yeu Lu
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Nat Science Committee
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Publication date
Application filed by Nat Science Committee filed Critical Nat Science Committee
Priority to TW80107818A priority Critical patent/TW208006B/en
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Publication of TW208006B publication Critical patent/TW208006B/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

An imidazole[1,2,c]quinazoline derivative of the following formula and its optically active racemic mixture and optically pure R and S stereoisomerides and its medical tolerable salt (see claim 1 (I)) in which: X is O or S; R1 is hydrogen, C1-C6 alkyl, phenyl or phenyl (C1-C6); R2 is hydrogen, C1-C6 alkyl, phenyl or phenyl (C1-C6); or R1 and R2 together represents alkylene of 4-10 carbon atom or (see claim 1) in which R5 represents (a) 2-, 3- or 4- pyridyl which is suitably substituted by one or two groups of C1-C4 alkyl; and (b) phenmethyl, phenyl, and diphenmethyl which are suitable substituted by one or two groups of halogen atom, methoxy and C1-C4 alkyl; and (i) R6 and R7 together represents alkylene of 4-6 carbon atom or (ii) (see claim 1 (ii)) or (iii) when R6 represents hydrogen or hydroxy, R7 represents (a) 2-, 3-, or 4-pyridyl which is suitably substituted by one or two groups of C1-C4 alkyl; and (b) benzoyl, benzyl and diphenmethyl which are suitably substituted by one or two groups of halogen atom, methoxy and C1-C4 alkyl; R3 is halogen, hydrogen, C1-C6 alkyl, or C1-C6 alkoxyl; and R4 is halogen, hydrogen, C1-C6 alkyl, or C1-C6 alkoxyl.
TW80107818A 1991-10-04 1991-10-04 A production method of 2-substituted methy1-2,3-dihydroimidazole[1,2,c]quinazoline-5(6H)-keto(thioxo) and its usage TW208006B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
TW80107818A TW208006B (en) 1991-10-04 1991-10-04 A production method of 2-substituted methy1-2,3-dihydroimidazole[1,2,c]quinazoline-5(6H)-keto(thioxo) and its usage

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
TW80107818A TW208006B (en) 1991-10-04 1991-10-04 A production method of 2-substituted methy1-2,3-dihydroimidazole[1,2,c]quinazoline-5(6H)-keto(thioxo) and its usage

Publications (1)

Publication Number Publication Date
TW208006B true TW208006B (en) 1993-06-21

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TW80107818A TW208006B (en) 1991-10-04 1991-10-04 A production method of 2-substituted methy1-2,3-dihydroimidazole[1,2,c]quinazoline-5(6H)-keto(thioxo) and its usage

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