TW202130384A - Variable magnetic field generation device - Google Patents

Abstract

The variable magnetic field generation device (1) according to the embodiments comprises a magnetic body (2), a drive unit (3), and a housing (4). The drive unit (3) moves the magnetic body (2) and thereby generates a variable magnetic field. The housing (4) houses the magnetic body (2) and the drive unit (3). The variable magnetic field that is generated from the magnetic body (2) as a result of the magnetic body (2) being moved by the drive unit (3) reduces the vibration of bioactive ions inside cells.

Description

變動磁場發生裝置Variable magnetic field generator

本發明的實施形態是關於一種變動磁場發生裝置。The embodiment of the present invention relates to a variable magnetic field generating device.

平滑肌會經由各種生物分子、神經傳遞物質、自泌物質(autacoid)、荷爾蒙等不同的特異性受體進行反應，而引發收縮或舒張。平滑肌可大致分為內臟平滑肌、血管平滑肌、眼瞼平滑肌(Muller muscle)，其存在部位廣泛地分布在消化系統(食道、胃、小腸、大腸、膽囊、膽管)、氣管、支氣管、輸精管、精囊、子宮、輸卵管、動脈和靜脈的血管系統等。該等平滑肌在消化、呼吸、生殖、循環、體溫調節、焦點光量調節方面扮演重要的角色。Smooth muscle reacts through different specific receptors such as various biomolecules, neurotransmitters, autacoids, hormones, etc., to trigger contraction or relaxation. Smooth muscle can be roughly divided into visceral smooth muscle, vascular smooth muscle, and eyelid smooth muscle (Muller muscle), and its existence is widely distributed in the digestive system (esophagus, stomach, small intestine, large intestine, gallbladder, bile duct), trachea, bronchus, vas deferens, seminal vesicle, uterus , Fallopian tubes, arteries and veins, etc. These smooth muscles play an important role in digestion, respiration, reproduction, circulation, body temperature regulation, and focus light intensity regulation.

平滑肌也會呈現出基於各個臟器特有的目的所發揮的功能和與伴隨該功能的形態。並且，平滑肌可藉由各式各樣的物質來引發如上所述的收縮舒張，但是即便是同一種物質，仍會因平滑肌的種類而造成相反的反應。Smooth muscle also exhibits functions based on the specific purpose of each organ and forms that accompany this function. In addition, smooth muscle can use various substances to trigger the contraction and relaxation as described above, but even the same substance will still cause the opposite reaction depending on the type of smooth muscle.

例如，子宮平滑肌會受到交感神經與副交感神經兩者控制，起因於副交感神經興奮的反應不會因人而異，但是起因於交感神經興奮的反應對於非孕期子宮會引發舒張，對於孕期子宮則會引發收縮。For example, uterine smooth muscle is controlled by both sympathetic and parasympathetic nerves. The response due to parasympathetic nerve excitement does not vary from person to person, but the response due to sympathetic nerve excitement triggers relaxation of the non-pregnant uterus, and for the gestational uterus Initiate shrinkage.

又，本發明中的細胞，只要是可在細胞內表現生理活性離子振盪和鈣離子振盪反應的細胞，可以是任一細胞，並無特別限制，例如除了平滑肌細胞以外，間葉細胞亦屬於這樣的細胞。間葉細胞是由源自中胚層或外胚層(神經脊)的細胞所構成的細胞群，主要形成胎兒的結締組織，並且具有分化成下述各式各樣的細胞的能力，該細胞是：軟骨母細胞、成骨細胞、神經細胞、神經膠細胞、皮膚色素細胞、副腎髓質細胞、骨和軟骨等間葉細胞、血管平滑肌細胞等。In addition, the cell in the present invention may be any cell as long as it can exhibit physiologically active ion oscillation and calcium ion oscillation response in the cell, and is not particularly limited. For example, in addition to smooth muscle cells, mesenchymal cells also fall into this category. Cell. Mesenchymal cells are a cell group composed of cells derived from the mesoderm or ectoderm (neural crest), which mainly form the connective tissue of the fetus, and have the ability to differentiate into the following types of cells. The cells are: Chondrocytes, osteoblasts, nerve cells, glial cells, skin pigment cells, adrenal medulla cells, mesenchymal cells such as bone and cartilage, vascular smooth muscle cells, etc.

此處，該平滑肌細胞較佳是：血管平滑肌與膀胱平滑肌與子宮平滑肌等的平滑肌細胞、間葉幹細胞、成骨細胞、免疫細胞或神經細胞等，特佳是血管平滑肌與膀胱平滑肌與子宮平滑肌等的平滑肌細胞或間葉幹細胞，進一步較佳是血管平滑肌細胞。Here, the smooth muscle cells are preferably smooth muscle cells such as vascular smooth muscle, bladder smooth muscle, and uterine smooth muscle, mesenchymal stem cells, osteoblasts, immune cells or nerve cells, etc., particularly preferably vascular smooth muscle, bladder smooth muscle, and uterine smooth muscle. The smooth muscle cells or mesenchymal stem cells of, are more preferably vascular smooth muscle cells.

雖然平滑肌的收縮舒張會產生各式各樣的反應，但是仍著重於此特性，藉由使用可發揮改變平滑肌的收縮舒張的狀態的效果且作用於平滑肌的藥物，而在各種疾病的治療方面有所助益。又，針對間葉細胞的分化和功能也使用了一種藥物，該藥物以控制疾病為目的，會對生理活性離子造成影響，而調節間葉細胞的分化和功能。 [先前技術文獻] (專利文獻)Although the contraction and relaxation of smooth muscle will produce a variety of responses, it still focuses on this feature. By using drugs that can change the state of contraction and relaxation of smooth muscle and act on smooth muscle, there are many treatments for various diseases. Helped. In addition, a drug is also used for the differentiation and function of mesenchymal cells. The drug has an effect on physiologically active ions for the purpose of controlling diseases and regulates the differentiation and function of mesenchymal cells. [Prior Technical Literature] (Patent Document)

專利文獻1：日本特開2011-162554號公報。Patent Document 1: Japanese Patent Application Laid-Open No. 2011-162554.

[發明所欲解決的問題] 然而，藉由藥物所進行的治療，大多會因患者的狀態而產生不同程度的效果，並且也有副作用的疑慮。又，亦需要考慮所使用的藥物本身無法用於患者的情況。從而，雖然藉由藥物所進行的治療大多有效，但另一方面也會有使用的情境受限的情況。[The problem to be solved by the invention] However, most of the treatments carried out by drugs will produce varying degrees of effects depending on the patient's condition, and there are also doubts about side effects. In addition, it is also necessary to consider the situation where the medication itself cannot be used for the patient. Therefore, although most of the treatments performed by drugs are effective, on the other hand, there are situations in which the use situation is limited.

本發明是為了解決上述問題而開發出來，本發明的目的在於提供一種變動磁場發生裝置，其利用變動磁場來謀求直接地抑制生理活性離子振盪，藉此，例如在平滑肌的情況下，能夠去除因平滑肌進行收縮而產生的缺陷。The present invention was developed to solve the above-mentioned problems. The object of the present invention is to provide a fluctuating magnetic field generator that uses a fluctuating magnetic field to directly suppress the oscillation of physiologically active ions, thereby, for example, in the case of smooth muscle, which can remove the factor. Defects caused by contraction of smooth muscles.

又，本發明的目的在於提供一種變動磁場發生裝置，其不僅可貼附在使用者的皮膚上來使用，例如亦能夠使用於下述情況：將磁力直接對準經分離的細胞，藉此確認細胞內的生理活性離子振盪和鈣離子振盪反應的表現。 [解決問題的技術手段]In addition, the object of the present invention is to provide a fluctuating magnetic field generating device, which can not only be attached to the skin of a user for use, for example, it can also be used in the following situations: the magnetic force is directly directed at the separated cells, thereby confirming the cells Physiologically active ion oscillation and calcium ion oscillation reaction performance. [Technical means to solve the problem]

實施形態中的變動磁場發生裝置，具備：磁性體、驅動部及殼體。驅動部，藉由使磁性體移動來使變動磁場發生。殼體，容納有磁性體與驅動部。本發明的變動磁場發生裝置的特徵在於：藉由驅動部使磁性體移動而發生的變動磁場，可使細胞內的生理活性離子的振盪降低，藉此當是在血管平滑肌的情況下，可抑制血管的收縮。The variable magnetic field generator in the embodiment includes a magnetic body, a drive unit, and a housing. The drive unit generates a fluctuating magnetic field by moving the magnetic body. The housing contains the magnetic body and the driving part. The fluctuating magnetic field generating device of the present invention is characterized in that the fluctuating magnetic field generated by the movement of the magnetic body by the driving part can reduce the oscillation of physiologically active ions in the cell, thereby suppressing the oscillation of the physiologically active ions in the vascular smooth muscle. Constriction of blood vessels.

又，較佳是生理活性離子是鈣離子。Furthermore, it is preferable that the physiologically active ion is calcium ion.

又，較佳是細胞是平滑肌細胞或間葉細胞。Furthermore, it is preferable that the cells are smooth muscle cells or mesenchymal cells.

又，較佳是磁性體所具備的複數個磁性部分的磁極皆為相同的磁極方向。Furthermore, it is preferable that the magnetic poles of the plurality of magnetic parts included in the magnetic body are all in the same magnetic pole direction.

又，較佳是磁性體具備表現相互地不同的複數個磁極方向的磁性部分。In addition, it is preferable that the magnetic body includes a magnetic portion that expresses a plurality of magnetic pole directions different from each other.

進一步，較佳是：磁性體具有流動性，驅動部藉由使磁性體以在環繞回路中循環的方式移動，來使變動磁場發生。Furthermore, it is preferable that the magnetic body has fluidity, and the drive unit moves the magnetic body in a circular loop to generate a fluctuating magnetic field.

進一步，當磁性體藉由驅動部而以能夠旋轉的方式來構成時，驅動部較佳是使磁性體以每分鐘旋轉500次以上的旋轉速度進行旋轉。Furthermore, when the magnetic body is configured to be rotatable by the drive unit, the drive unit preferably rotates the magnetic body at a rotation speed of 500 times or more per minute.

進一步，實施形態中的變動磁場發生裝置，具備：磁性體、磁屏蔽材料、驅動部及殼體。磁屏蔽材料可部分地屏蔽磁性體的磁性。驅動部可使磁屏蔽材料旋轉。殼體容納有磁性體、磁屏蔽材料及驅動部。並且，當磁性體被固定時，驅動部藉由使磁屏蔽材料旋轉而使變動磁場發生。Furthermore, the variable magnetic field generator in the embodiment includes a magnetic body, a magnetic shielding material, a drive unit, and a housing. The magnetic shielding material can partially shield the magnetism of the magnetic body. The driving part can rotate the magnetic shielding material. The casing contains a magnetic body, a magnetic shielding material, and a driving part. In addition, when the magnetic body is fixed, the drive unit rotates the magnetic shielding material to generate a fluctuating magnetic field.

又，磁屏蔽材料較佳是具備變動磁場可通過的間隙。In addition, the magnetic shielding material preferably has a gap through which a variable magnetic field can pass.

又，磁屏蔽材料，較佳是其一部分具備由磁屏蔽性低的材料所構成之部位，並且變動磁場可通過該部位。In addition, it is preferable that a part of the magnetic shielding material has a portion made of a material with low magnetic shielding properties, and a variable magnetic field can pass through the portion.

進一步，驅動部，較佳是使磁屏蔽材料以每分鐘旋轉500次以上的旋轉速度進行旋轉。Furthermore, the drive unit preferably rotates the magnetic shielding material at a rotation speed of 500 times or more per minute.

磁性體，較佳是被配置在從安裝有變動磁場發生裝置之對象算起約13mm以內的位置。The magnetic body is preferably arranged at a position within about 13 mm from the object on which the variable magnetic field generating device is installed.

實施形態中的變動磁場發生裝置，較佳是：進一步具備載物台，該載物台上具有載置細胞之腔室；並且，磁性體，以垂直地貫穿於載置面的軸作為旋轉軸，並在與載置面平行的面上，在被載置於腔室中的細胞周圍進行移動。The variable magnetic field generating device in the embodiment preferably further includes a stage having a chamber for placing cells on the stage; and the magnetic body has an axis perpendicularly penetrating the placing surface as the axis of rotation , And move around the cells placed in the chamber on a surface parallel to the placement surface.

又，較佳是在載物台上設置有單數個或複數個腔室。Furthermore, it is preferable to provide a singular or plural chambers on the stage.

實施形態中的變動磁場發生裝置，較佳是：進一步具備載物台，該載物台上具有載置細胞之腔室；並且，複數個磁性體，被配置在夾持細胞且相互地相對向的位置，且相對於被載置於腔室中的細胞，以與載置面平行的軸也就是複數個磁性體所共有的軸作為旋轉軸來進行旋轉。The variable magnetic field generating device in the embodiment preferably further includes a stage with a chamber for placing cells on the stage; and a plurality of magnetic bodies are arranged to hold the cells and face each other. With respect to the cell placed in the chamber, it rotates with the axis parallel to the placement surface, that is, the axis shared by the plurality of magnetic bodies as the axis of rotation.

較佳是複數個磁性體皆朝相同方向旋轉。It is preferable that the plural magnetic bodies all rotate in the same direction.

又，較佳是在載物台上設有1個腔室。Furthermore, it is preferable to provide one chamber on the stage.

進一步，較佳是當磁性體藉由驅動部而以能夠旋轉的方式來構成時，驅動部使磁性體以每分鐘旋轉500次以上的旋轉速度進行旋轉。 [發明的效果]Further, it is preferable that when the magnetic body is configured to be rotatable by the driving part, the driving part rotates the magnetic body at a rotation speed of 500 times or more per minute. [Effects of the invention]

本發明因為採用了如此的構成，所以能夠提供一種變動磁場發生裝置，其利用變動磁場來達到直接地抑制生理活性離子的振盪，藉此，例如在平滑肌的情況下，藉由達到抑制平滑肌的收縮，而能夠去除因平滑肌進行收縮所產生的缺陷。Since the present invention adopts such a structure, it is possible to provide a variable magnetic field generating device that uses a variable magnetic field to directly suppress the oscillation of physiologically active ions, thereby, for example, in the case of smooth muscle, by suppressing the contraction of smooth muscle , And can remove defects caused by smooth muscle contraction.

又，能夠提供一種變動磁場發生裝置，其不僅能夠在貼附在使用者的皮膚上的情況下來使用，例如亦能夠使用於下述情況：將磁力直接對準經分離的細胞，藉此確認細胞內的生理活性離子振盪和鈣離子振盪反應的表現。In addition, it is possible to provide a variable magnetic field generating device that can be used not only in the case of being attached to the skin of a user, but also in a case where, for example, the magnetic force is directly directed at the separated cells, thereby confirming the cells Physiologically active ion oscillation and calcium ion oscillation reaction performance.

以下，參照圖式詳細地說明實施形態。Hereinafter, the embodiment will be described in detail with reference to the drawings.

(第一實施形態) [變動磁場發生裝置的構成] 第1圖是顯示第一實施形態中的變動磁場發生裝置1的整體構成的剖面圖。如第1圖所示，本發明的第一實施形態中的變動磁場發生裝置1，被貼附在使用者的皮膚S上來使用。第1圖所示的變動磁場發生裝置1，顯示了被貼附在皮膚S上的狀態。(First Embodiment) [Constitution of Variable Magnetic Field Generator] Fig. 1 is a cross-sectional view showing the overall configuration of the variable magnetic field generator 1 in the first embodiment. As shown in Fig. 1, the fluctuating magnetic field generating device 1 in the first embodiment of the present invention is attached to the skin S of the user for use. The fluctuating magnetic field generating device 1 shown in FIG. 1 shows a state of being attached to the skin S.

藉由這樣的方式，變動磁場發生裝置1被貼附在使用者的皮膚S上來使用，所發生的變動磁場可被賦予至皮膚S和皮膚S的表面附近的體內各處。In this way, the fluctuating magnetic field generating device 1 is attached to the skin S of the user for use, and the generated fluctuating magnetic field can be applied to the skin S and various parts of the body near the surface of the skin S.

再者，有關變動磁場發生裝置1所貼附的位置，並無特別限定，只要是脖子和肩膀、腹部和腰部的皮膚等能夠利用由變動磁場所產生的效果的位置，可以貼附在任何位置上。Furthermore, there is no particular limitation on the location where the variable magnetic field generating device 1 is attached. It can be attached to any location as long as it is the skin of the neck, shoulders, abdomen and waist, etc., where the effects produced by the variable magnetic field can be used. superior.

變動磁場發生裝置1，具備磁性體2、驅動部3及殼體4。如上所述，第1圖顯示了貼附在使用變動磁場發生裝置1之使用者的皮膚S上的狀態。此時，變動磁場發生裝置1中的殼體4會直接地接觸皮膚S。The variable magnetic field generator 1 includes a magnetic body 2, a drive unit 3, and a casing 4. As described above, Fig. 1 shows the state of being attached to the skin S of the user using the variable magnetic field generating device 1. At this time, the housing 4 in the fluctuating magnetic field generator 1 will directly contact the skin S.

又，殼體4的內部容納有磁性體2與驅動部3，但是也可將磁性體2配置在更靠近皮膚S的位置上，並在磁性體2的上部上配置驅動部3，也就是以夾持磁形體2的方式在與皮膚S相對向的位置上配置驅動部3。In addition, the housing 4 contains the magnetic body 2 and the drive part 3, but the magnetic body 2 may be arranged closer to the skin S, and the drive part 3 may be arranged on the upper part of the magnetic body 2, that is, In the manner of sandwiching the magnetic body 2, the driving unit 3 is arranged at a position facing the skin S.

又，在第1圖中，顯示了將磁性體2與驅動部3連接的軸5，該軸5顯示了一種旋轉軸，其是驅動部3用以使作為磁性體2的一例的圓盤狀的磁性體2進行旋轉者。Also, in Figure 1, there is shown a shaft 5 connecting the magnetic body 2 and the drive part 3. The shaft 5 shows a kind of rotating shaft which is used by the drive part 3 to make a disk-shaped as an example of the magnetic body 2. The magnetic body 2 is rotated.

再者，在第1圖中，並未顯示磁性體2和驅動部3的詳情。這是因為，磁性體2與驅動部3如同後述，能夠採用各式各樣的配置、形狀、態樣等。Furthermore, in Fig. 1, the details of the magnetic body 2 and the drive unit 3 are not shown. This is because the magnetic body 2 and the drive unit 3 can adopt various arrangements, shapes, patterns, etc., as described later.

磁性體2會藉由後述的驅動部3被移動而發生變動磁場。再者，本說明書中，所謂「變動磁場」，意指磁場的朝向和強度進行變動的情況。The magnetic body 2 is moved by the drive unit 3 described later to generate a fluctuating magnetic field. In addition, in this specification, the "variable magnetic field" means a situation where the direction and intensity of the magnetic field are changed.

又，在以下本發明的實施態樣中，所謂「磁性體」，意指能夠帶有磁性之物質或組成、構造，而不論是固體、流體這樣的物的態樣或利用態樣(例如，磁石、磁性流體等)。也可以是內部包含複數個磁石之構造或包含電磁石之構造。In addition, in the following embodiments of the present invention, the so-called "magnetic body" means a substance, composition, or structure capable of being magnetic, regardless of the state of a solid, fluid, or the state of use (for example, Magnets, magnetic fluids, etc.). It may also be a structure containing a plurality of magnets or a structure containing electromagnets.

亦即，作為磁性體2，例如可以是磁石、電磁石或帶有磁性之流體(磁性流體)中的任一種。又，例如當磁性體2是磁石時，磁性體2只要是鐵氧體、釹、釤鈷、鋁鎳鈷、鐵鉻鈷、鐵白金等具備磁性者即可，能夠使用任一種材質。That is, as the magnetic body 2, for example, any one of a magnet, an electromagnet, and a magnetic fluid (magnetic fluid) may be used. Also, for example, when the magnetic body 2 is a magnet, the magnetic body 2 may be any material that has magnetism such as ferrite, neodymium, samarium cobalt, alnico, iron chromium cobalt, iron platinum, and the like.

磁性體2的數量可以是單數、複數中的任一種。例如，當磁性體2形成為圓盤狀時，能夠是下述形態：磁性體2為1個，並將該磁性體2的中心設為旋轉軸而使其旋轉來使用。又，亦可利用下述方式來構成：藉由組合複數個磁性體2並使其移動，來使變動磁場發生。The number of magnetic bodies 2 may be either singular or plural. For example, when the magnetic body 2 is formed in a disk shape, it can be used in a form in which the magnetic body 2 is one, and the center of the magnetic body 2 is used as a rotation axis to rotate it. In addition, it can also be configured by a method in which a plurality of magnetic bodies 2 are combined and moved to generate a fluctuating magnetic field.

又，有關磁性體2所具備的複數個磁性部分的磁極，可以是同極(N極與N極、或S極與S極這樣的相同的磁極方向)或異極(N極與S極、或S極與N極這樣的不同的磁極方向)中的任一種。這是因為藉由賦予變動磁場而發生於使用者的體內各處的反應非常地快的緣故。In addition, the magnetic poles of the plurality of magnetic parts included in the magnetic body 2 may be the same pole (N pole and N pole, or S pole and S pole in the same magnetic pole direction) or different poles (N pole and S pole, Or any of the different magnetic pole directions such as the S pole and the N pole). This is because the reactions that occur everywhere in the user's body by applying a variable magnetic field are very fast.

亦即，例如上述那樣，磁形體2被形成為圓盤狀並藉由驅動部3使磁性體2旋轉時，例如能夠以第一磁極、第二磁極、第三磁極、第N磁極這樣的方式，藉由複數個磁極來使變動磁場連續而賦予至使用者的體內。That is, for example, as described above, when the magnetic body 2 is formed in a disc shape and the magnetic body 2 is rotated by the drive unit 3, for example, the first magnetic pole, the second magnetic pole, the third magnetic pole, and the Nth magnetic pole can be used. , The variable magnetic field is continuously applied to the user's body by using a plurality of magnetic poles.

此時，藉由利用第一磁極所賦予的變動磁場而發生於體內各處的反應，會在藉由接續的第二磁極賦予變動磁場之前結束。並且，此現象對於藉由利用第二磁極所賦予的變動磁場的反應，同樣會在利用第三磁極賦予變動磁場之前結束。At this time, the reactions occurring throughout the body by using the variable magnetic field imparted by the first magnetic pole will end before the continuous second magnetic pole imparts the variable magnetic field. In addition, the reaction of this phenomenon to the fluctuating magnetic field imparted by the second magnetic pole also ends before the fluctuating magnetic field is imparted by the third magnetic pole.

因此，賦予變動磁場且為連續的磁極不論是相同的磁極或不同的磁極，都不會造成問題，所以賦予變動磁場且為連續的磁極可以是同極，也可以是異極。Therefore, the continuous magnetic poles given the variable magnetic field will not cause problems regardless of the same magnetic pole or different magnetic poles. Therefore, the continuous magnetic poles given the variable magnetic field may be of the same pole or different poles.

又，針對磁性體2的配置，也能夠採用任何配置。第2圖～第4圖，是針對第一實施形態中的變動磁場發生裝置1中的磁性體2，顯示各式各樣的配置、形狀、態樣的一例的示意圖。In addition, with regard to the arrangement of the magnetic body 2, any arrangement can also be adopted. FIGS. 2 to 4 are schematic diagrams showing examples of various arrangements, shapes, and aspects of the magnetic body 2 in the variable magnetic field generating device 1 in the first embodiment.

其中，較佳是：磁性體2，相對於殼體4的底面(與使用者的皮膚S接觸的面)，以使連結磁極彼此之軸大約呈垂直的方式來配置。藉由以這樣的方式來配置，磁性體2的磁極方向相對於殼體4的底面(皮膚S的表面)會變得大約呈垂直地延伸。因此，比起使用磁極方向相對於底面(皮膚S的表面)為平行地延伸的磁性體的情況，相對於皮膚S的表面大約呈垂直的方向的磁場強度會變大，而磁力會變得能夠作用到比皮膚S的表面更深的體內。Among them, it is preferable that the magnetic body 2 is arranged with respect to the bottom surface of the casing 4 (the surface in contact with the user's skin S) such that the axis connecting the magnetic poles is approximately perpendicular. By arranging in this manner, the magnetic pole direction of the magnetic body 2 becomes approximately perpendicular to the bottom surface of the casing 4 (the surface of the skin S). Therefore, compared to the case of using a magnetic body whose magnetic pole direction is parallel to the bottom surface (the surface of the skin S), the intensity of the magnetic field approximately perpendicular to the surface of the skin S will increase, and the magnetic force will become more effective. It affects the body deeper than the surface of the skin S.

第2圖中，顯示了被形成為圓盤狀的磁性體2A。在該磁性體2A的中心部中設置有旋轉軸5，來將磁性體2A與驅動部3進行連結，該旋轉軸5會受到來自驅動部3的驅動力的傳遞。Fig. 2 shows a magnetic body 2A formed in a disk shape. A rotating shaft 5 is provided in the central part of the magnetic body 2A to connect the magnetic body 2A and the driving part 3, and the rotating shaft 5 receives the transmission of the driving force from the driving part 3.

在第2圖的磁性體2A中，以2個N極、S極彼此交錯地出現的方式來配置。但是如上所述，這樣連續的磁極並未限定於異極，也可以是同極。In the magnetic body 2A in Fig. 2, two N poles and S poles are arranged in a staggered manner. However, as described above, such continuous magnetic poles are not limited to different poles, and may be the same pole.

第3圖所示的磁性體2B，採用了以使被形成為棒狀體的2個磁性體彼此正交的方式組合而成的形狀。在該磁性體2B的中心部中，也設置有旋轉軸5，來將磁性體2B與驅動部3進行連結，該旋轉軸5會受到來自驅動部3的驅動力的傳遞。The magnetic body 2B shown in FIG. 3 has a shape formed by combining two magnetic bodies formed as rod-shaped bodies so as to be orthogonal to each other. In the central part of the magnetic body 2B, a rotating shaft 5 is also provided to connect the magnetic body 2B and the driving part 3, and the rotating shaft 5 receives the transmission of the driving force from the driving part 3.

再者，在第3圖所示的磁性體2B中，雖然並未表示磁極，但是如上所述，連續的磁極可以是異極或同極中的任一種。Furthermore, in the magnetic body 2B shown in FIG. 3, although the magnetic poles are not shown, as described above, the continuous magnetic poles may be either different poles or the same poles.

不同於截至目前為止所說明的磁性體2A、2B，第4圖所示的磁性體2C具有下述特徵：以具有流動性的磁性流體來構成，而非作為固體的磁石。磁性體2C具有循環管路2C2與泵2C3，該循環管路2C2用以將磁性流體2C1保持在其內部並使磁性流體2C1循環，該泵2C3用以使磁性流體2C1在循環管路2C2內進行循環。Different from the magnetic bodies 2A and 2B described so far, the magnetic body 2C shown in FIG. 4 has the following characteristics: it is composed of a fluid magnetic fluid instead of a solid magnet. The magnetic body 2C has a circulation line 2C2 and a pump 2C3. The circulation line 2C2 is used to keep the magnetic fluid 2C1 inside and circulate the magnetic fluid 2C1. The pump 2C3 is used to make the magnetic fluid 2C1 perform in the circulation line 2C2. cycle.

磁性體2C，在殼體4的內部中被配置在最靠近使用者的皮膚S的位置，磁性流體2C1藉由泵2C3在循環管路2C2內進行循環，藉此對皮膚S的內部賦予變動磁場。The magnetic body 2C is arranged at the position closest to the skin S of the user in the inside of the housing 4. The magnetic fluid 2C1 is circulated in the circulation line 2C2 by the pump 2C3, thereby imparting a fluctuating magnetic field to the inside of the skin S .

此處的磁性體2C是利用下述方式形成：循環管路2C2，以磁性流體2C1能夠使在其內部循環的方式來描繪出環繞回路。The magnetic body 2C here is formed by the following method: the circulation line 2C2 draws a loop in such a way that the magnetic fluid 2C1 can circulate the inside thereof.

這樣的磁性體2，不僅可藉由上述的旋轉來使變動磁場發生，也可以作成如第4圖所示的那樣，以磁性流體2C1在循環管路2C2內流動的方式來實行直線性的移動，藉此使變動磁場發生。Such a magnetic body 2 can not only generate a fluctuating magnetic field by the above-mentioned rotation, but can also be made to move linearly with the magnetic fluid 2C1 flowing in the circulation pipe 2C2 as shown in Fig. 4 , Thereby making the fluctuating magnetic field occur.

再者，第4圖所示的循環管路2C2的配置僅為例示。除了第4圖所示的配置以外，也能夠作成拉長磁性體2的移動距離的形狀，其例如是來回地配置循環管路2C2、或使循環管路2C2迂迴地配置。In addition, the arrangement of the circulation line 2C2 shown in Fig. 4 is only an example. In addition to the arrangement shown in FIG. 4, it is also possible to form a shape that elongates the moving distance of the magnetic body 2, for example, by arranging the circulation duct 2C2 back and forth, or by arranging the circulation duct 2C2 in a circuitous manner.

再者，雖然並未以圖式進行說明，但是磁性體2例如也可以是電磁石。當磁性體2是電磁石時，可承受來自直流或交流電源的電源的供給來對使用者的體內賦予變動磁場。又，此時，可設置控制電磁石也就是磁性體2之控制部。In addition, although it is not illustrated in the drawings, the magnetic body 2 may be, for example, an electromagnet. When the magnetic body 2 is an electromagnet, it can withstand the supply of power from a DC or AC power source to impart a variable magnetic field to the user's body. Also, at this time, a control unit that controls the magnet 2 that is the magnet 2 can be installed.

這樣的磁性體2，只要是可使變動磁場發生的態樣，可採用如截至目前為止的說明中的任何配置、形狀、態樣。As long as such a magnetic body 2 can generate a variable magnetic field, any arrangement, shape, and aspect as in the description so far can be adopted.

驅動部3，可藉由使磁性體2移動來使變動磁場發生。驅動部3，例如當如上所述地以磁性體2能夠旋轉的方式來構成時，能夠採用一種經由軸5來對該磁性體2施加旋轉之機構。The drive unit 3 can generate a fluctuating magnetic field by moving the magnetic body 2. For example, when the drive unit 3 is configured such that the magnetic body 2 can rotate as described above, a mechanism for applying rotation to the magnetic body 2 via the shaft 5 can be adopted.

作為施加旋轉之機構，例如可考慮馬達或螺旋彈簧這樣的機構。又，當要施加旋轉時，可以直接利用馬達等來使磁性體2旋轉，或者也可以採用一種使用滑輪或齒輪等來傳遞旋轉之機構。As a mechanism for applying rotation, for example, a mechanism such as a motor or a coil spring can be considered. In addition, when rotation is to be applied, a motor or the like can be used directly to rotate the magnetic body 2, or a mechanism that uses pulleys or gears to transmit the rotation can also be adopted.

再者，當驅動部3例如是馬達時，為了發揮磁性體2的效果，需要充分地隔開馬達與磁性體2之間的距離。針對該距離，能夠藉由調整軸5的長度來確保。Furthermore, when the driving unit 3 is a motor, for example, in order to exhibit the effect of the magnetic body 2, it is necessary to sufficiently separate the distance between the motor and the magnetic body 2. This distance can be ensured by adjusting the length of the shaft 5.

又，當磁性體2是磁性流體2C1時，可如上所述地使用泵2C3。驅動部3藉由驅動該泵2C3，可使磁性流體2C1在循環管路2C2內進行循環。In addition, when the magnetic body 2 is the magnetic fluid 2C1, the pump 2C3 can be used as described above. The driving unit 3 drives the pump 2C3 to allow the magnetic fluid 2C1 to circulate in the circulation line 2C2.

再者，截至目前為止已說明了驅動部3使磁性體2旋轉等的情況，但是例如可以預先將磁性體2固定於殼體4的內部，並且驅動部3例如以使遮蔽板旋轉來對使用者賦予變動磁場的方式來構成，該遮蔽板可被賦予來自磁性體2的部分的變動磁場。In addition, the case where the drive unit 3 rotates the magnetic body 2 has been described so far, but for example, the magnetic body 2 may be fixed to the inside of the housing 4 in advance, and the drive unit 3 may be used to rotate the shielding plate, for example. The shielding plate can be provided with a variable magnetic field from a portion of the magnetic body 2.

例如，藉由使設置有間隙的磁屏蔽材料圍繞被固定的磁性體的周圍進行旋轉，可部分地阻斷磁性體的磁力，藉此，能夠使遮蔽位置變化來發生變動磁場。此處，作為磁屏蔽材料，例如能夠使用高導磁合金。For example, by rotating the magnetic shielding material provided with the gap around the fixed magnetic body, the magnetic force of the magnetic body can be partially blocked, whereby the shielding position can be changed to generate a fluctuating magnetic field. Here, as the magnetic shielding material, for example, a high-permeability alloy can be used.

又，磁屏蔽材料，例如可在部分的磁屏蔽材料上具備由磁屏蔽性低的材料所構成的部位來取代間隙。藉由如此的磁屏蔽材料圍繞磁性體的周圍進行旋轉，能夠利用該磁屏蔽性低的材料的部位來使變動磁場發生。In addition, the magnetic shielding material may include, for example, a part of the magnetic shielding material with a portion made of a material with low magnetic shielding properties instead of the gap. By rotating such a magnetic shielding material around the periphery of the magnetic body, it is possible to generate a fluctuating magnetic field using the portion of the material with low magnetic shielding performance.

如第1圖所示，殼體4的內部空間容納有磁性體2與驅動部3。殼體4包圍內部空間，並且具有頂面、側面及底面，該底面在變動磁場發生裝置1貼附在皮膚S上時接觸皮膚S。本發明的實施形態中，例如變動磁場發生裝置1藉由被設置在殼體4的底面的習知的黏著片，底面會以間接地接觸使用者的皮膚S的方式貼附在該皮膚S上。As shown in FIG. 1, the magnetic body 2 and the drive unit 3 are accommodated in the internal space of the housing 4. The housing 4 surrounds the internal space, and has a top surface, a side surface, and a bottom surface, and the bottom surface contacts the skin S when the variable magnetic field generating device 1 is attached to the skin S. In the embodiment of the present invention, for example, the fluctuating magnetic field generating device 1 is attached to the skin S of the user in a manner of indirectly contacting the skin S of the user by using a conventional adhesive sheet provided on the bottom surface of the housing 4 .

針對殼體4的形狀，只要可形成內部空間並具有與使用者的皮膚S接觸的底面，可形成為任何的形狀，例如：大約圓柱狀、大約多角柱狀，該內部空間的大小可容納能夠該內部空間移動的磁性體2。With regard to the shape of the housing 4, as long as it can form an internal space and has a bottom surface in contact with the user’s skin S, it can be formed in any shape, such as approximately cylindrical or approximately polygonal columnar. The size of the internal space can accommodate The magnetic body 2 moves in the internal space.

又，殼體4的成形材料並無特別限定，只要在承受來自外部的力時能夠維持內部空間的形狀，並且磁性體2的磁力線可容易地穿透即可。從而，能夠適用例如：丙烯腈-丁二烯-苯乙烯共聚物(ABS)、聚碳酸酯-丙烯腈-丁二烯-苯乙烯共聚物(PC-ABS)、聚乙烯(PE)或聚對苯二甲酸乙二酯(PET)等合成樹脂材料。In addition, the molding material of the housing 4 is not particularly limited, as long as it can maintain the shape of the internal space when receiving a force from the outside, and the magnetic field lines of the magnetic body 2 can easily penetrate. Therefore, it can be applied to, for example, acrylonitrile-butadiene-styrene copolymer (ABS), polycarbonate-acrylonitrile-butadiene-styrene copolymer (PC-ABS), polyethylene (PE) or polymer Synthetic resin materials such as ethylene phthalate (PET).

再者，例如在驅動部3使磁性體2移動來發生變動磁場這樣的情況下，實際上會將輸入部和輸出部等設置於變動磁場發生裝置1中，但是在第1圖所示的變動磁場發生裝置1中省略了輸入部和輸出部的繪製，該輸入部使變動磁場發生裝置1運作，該輸出部將變動磁場發生裝置1運作中的狀態通知使用者。Furthermore, for example, in the case where the drive unit 3 moves the magnetic body 2 to generate a fluctuating magnetic field, the input unit and output unit are actually provided in the fluctuating magnetic field generator 1, but the variation shown in Fig. 1 The drawing of the input unit and the output unit are omitted in the magnetic field generating device 1. The input unit operates the variable magnetic field generating device 1, and the output unit notifies the user of the operating state of the variable magnetic field generating device 1.

例如，針對輸入部，可由用以開啟電源的開關等、各種開關或旋鈕等來構成，而接收來自使用者的各式各樣的輸入操作。作為該輸入部，除了這樣的開關以外，能夠使用例如：GUI(Graphical User Interface，圖形化使用者介面)或按鈕這樣的各式各樣的形態的輸入元件。For example, the input unit may be constituted by a switch for turning on the power, various switches or knobs, etc., and receive various input operations from the user. As the input unit, in addition to such a switch, various input elements such as GUI (Graphical User Interface) and buttons can be used.

又，如上所述，例如當驅動部3是使用螺旋彈簧之機構時，纏繞螺旋彈簧的轉柄等也能夠包含在輸入部中。In addition, as described above, for example, when the drive unit 3 is a mechanism using a coil spring, a handle that winds the coil spring and the like can also be included in the input unit.

另一方面，針對輸出部，例如能夠列舉顯示燈等，其可對使用者表示變動磁場發生裝置1的啟動(ON)、關閉(OFF)等運作狀態。再者，作為輸出部，只要是聽覺等訴諸五感的顯示即可，而不限於上述對使用者提供這樣的視覺上的顯示。On the other hand, for the output unit, for example, a display lamp or the like can be cited, which can indicate to the user the operating status of the variable magnetic field generating device 1 such as on (ON) and off (OFF). Furthermore, as the output unit, any display that appeals to the five senses such as hearing is sufficient, and it is not limited to such a visual display to the user as described above.

[運作] 繼而，以下利用第5圖來說明藉由變動磁場發生裝置1的運作和磁性體2進行移動所獲得的效果。第5圖是顯示使用第一實施形態中的變動磁場發生裝置對使用者賦予變動磁場時的效果的波形圖。[Operation] Next, the effect obtained by the operation of the variable magnetic field generating device 1 and the movement of the magnetic body 2 will be explained using FIG. 5 below. Fig. 5 is a waveform diagram showing the effect of applying a variable magnetic field to the user using the variable magnetic field generating device in the first embodiment.

首先，以血管的擴張和收縮為例，說明賦予外部刺激時的細胞的一般性的作用機制。例如，若對血管賦予外部刺激，會影響到血管內皮細胞與血管平滑肌細胞的內部中的細胞內鈣離子。First, take the expansion and contraction of blood vessels as an example to illustrate the general mechanism of action of cells when external stimuli are given. For example, if an external stimulus is given to blood vessels, it will affect intracellular calcium ions in the interior of vascular endothelial cells and vascular smooth muscle cells.

當血管內皮細胞中的細胞內鈣離子受到外部刺激而上升時，會以促進血管的擴張的方式來作用。另一方面，當血管平滑肌細胞中的細胞內鈣離子受到外部刺激而上升時，會以促進血管的收縮的方式來作用。When the intracellular calcium ions in vascular endothelial cells rise by external stimulation, they act in a way that promotes the expansion of blood vessels. On the other hand, when intracellular calcium ions in vascular smooth muscle cells are increased by external stimulation, they act in a way that promotes the contraction of blood vessels.

其中，藉由血管內皮細胞的血管擴張促進作用中，在血管內皮細胞中，會藉由細胞內鈣離子進行作用而使一氧化氮合成蛋白質被活化，其所產生的一氧化氮會移動至血管平滑肌細胞，因而能夠使得血管平滑肌細胞以抑制血管收縮的方式作用。Among them, the vascular endothelial cell promotes vasodilation. In the vascular endothelial cell, the intracellular calcium ions activate the nitric oxide synthesis protein, and the produced nitric oxide moves to the blood vessel. Smooth muscle cells can thus cause vascular smooth muscle cells to act in a way that inhibits vasoconstriction.

又，在血管內皮細胞與血管平滑肌細胞中，若檢視基於外部刺激而出現血管舒張作用的出現情況時，可知藉由血管內皮細胞的反應比起藉由血管平滑肌細胞的反應更早出現也更早結束。In addition, in vascular endothelial cells and vascular smooth muscle cells, if the appearance of vasodilation based on external stimuli is examined, it can be seen that the response by vascular endothelial cells appears earlier and earlier than the response by vascular smooth muscle cells. Finish.

此處，檢視第5圖的波形圖。該波形圖顯示了下述結果，其是在對所採取的血管平滑肌細胞添加用來檢測生理活性離子的螢光指示劑後，賦予變動磁場，並使用螢光顯微鏡來觀察血管平滑肌細胞的反應而得。Here, check the waveform diagram in Figure 5. The waveform chart shows the following results. After adding a fluorescent indicator for detecting physiologically active ions to the collected vascular smooth muscle cells, applying a fluctuating magnetic field, and using a fluorescent microscope to observe the response of the vascular smooth muscle cells. have to.

在波形圖中，橫軸表示時間。另一方面，縱軸表示從螢光強度所換算出的生理活性離子濃度。該數值越高，表示細胞內生理活性離子的濃度變得越高。這與在血管平滑肌細胞中促進血管的收縮的情況有關。從而，能夠視為血管平滑肌細胞產生了血管收縮的情況。In the waveform graph, the horizontal axis represents time. On the other hand, the vertical axis represents the physiologically active ion concentration converted from the fluorescence intensity. The higher the value, the higher the concentration of physiologically active ions in the cell. This is related to the promotion of the contraction of blood vessels in vascular smooth muscle cells. Therefore, it can be considered that the vascular smooth muscle cells have contracted blood vessels.

另一方面，數值低的狀態表示細胞內生理活性離子的濃度變低。若細胞內生理活性離子的濃度變低，就會減緩血管平滑肌細胞中的血管收縮的作用，反而會使血管內皮細胞中的血管擴張的作用強烈地表現出來。也就是說，若細胞內生理活性離子的濃度變低，會變得顯現出血管舒張的狀態。On the other hand, a state with a low value indicates that the concentration of physiologically active ions in the cell becomes low. If the concentration of physiologically active ions in the cell becomes lower, the vasoconstriction effect in the vascular smooth muscle cells will be slowed down, and the vasodilation effect in the vascular endothelial cells will be strongly expressed. In other words, if the concentration of physiologically active ions in the cell becomes lower, a state of vasodilation will appear.

又，在波形圖中，在900秒的部分畫有一縱線。該縱線是區分是否藉由變動磁場發生裝置1對使用者的體內賦予變動磁場的線。亦即，該縱線的左側，也就是在900秒之前並未賦予變動磁場。另一方面，該縱線的右側，也就是在900秒以後賦予有變動磁場。Also, in the waveform diagram, a vertical line is drawn at the 900-second portion. The vertical line is a line that distinguishes whether or not a variable magnetic field is applied to the user's body by the variable magnetic field generator 1. That is, on the left side of the vertical line, that is, no fluctuating magnetic field was applied before 900 seconds. On the other hand, on the right side of the vertical line, that is, a fluctuating magnetic field is applied after 900 seconds.

在藉由變動磁場發生裝置1賦予變動磁場前，在血管平滑肌細胞中，細胞內生理活性離子會進行作用，並藉由細胞內生理活性離子的濃度波動這樣的週期性的變動，來表現出引發血管收縮的平均時間。Before the fluctuating magnetic field is applied by the fluctuating magnetic field generator 1, in the vascular smooth muscle cells, the intracellular physiologically active ions will act, and the intracellular physiologically active ion concentration fluctuates periodically to show the initiation The average time for vasoconstriction.

但是，在藉由變動磁場發生裝置1對使用者的血管賦予變動磁場的900秒後，相較於賦予變動磁場前，細胞內生理活性離子的濃度會降低。However, 900 seconds after the fluctuating magnetic field is applied to the blood vessel of the user by the fluctuating magnetic field generator 1, the concentration of physiologically active ions in the cell will decrease compared to before the fluctuating magnetic field is applied.

若是不論是否賦予變動磁場，細胞內生理活性離子的濃度都不會產生變化的情況，應該會出現如第5圖的虛線所表示的波形。然而，在賦予如上所述的變動磁場後，細胞內生理活性離子的濃度卻降低了。這樣的情況也就表示了維持了持續舒張的狀態，而沒有發生血管的收縮。If there is no change in the concentration of physiologically active ions in the cell regardless of whether a variable magnetic field is applied or not, a waveform like the dotted line in Figure 5 should appear. However, after applying the above-mentioned variable magnetic field, the concentration of physiologically active ions in the cell decreases. This situation also means that the state of continuous diastole has been maintained without vasoconstriction.

從以上的結果可知，藉由以變動磁場發生裝置1賦予變動磁場，細胞內生理活性離子的濃度波動這樣的週期性的變動(振盪)會降低(消失)，並且細胞內生理活性離子的濃度會被抑制得較低。From the above results, it can be seen that by applying the variable magnetic field with the variable magnetic field generator 1, periodic fluctuations (oscillations) such as fluctuations in the concentration of physiologically active ions in the cells are reduced (disappeared), and the concentration of physiologically active ions in the cells is reduced. Is suppressed low.

又，若血管舒張而不會收縮的狀態持續進行，能夠認為是因為所賦予的變動磁場直接作用於血管平滑肌細胞，而阻礙藉由血管平滑肌細胞產生的血管收縮的作用。血管收縮的作用受到阻礙，也就是發生血管擴張的狀態。In addition, if the state of vasodilation without contraction continues, it can be considered that the applied variable magnetic field directly acts on the vascular smooth muscle cells and hinders the effect of vasoconstriction by the vascular smooth muscle cells. The effect of vasoconstriction is hindered, that is, the state of vasodilation.

從而，在藉由變動磁場發生裝置1賦予變動磁場的狀態下，血管擴張的狀態會持續，並且若血管擴張會使得血液循環變好，例如可謀求血流的改善。Therefore, in the state where the variable magnetic field is applied by the variable magnetic field generating device 1, the state of blood vessel expansion continues, and if the blood vessel expands, the blood circulation becomes better, for example, the blood flow can be improved.

如此地抑制血管平滑肌細胞中的細胞內生理活性離子的振盪，而達到使細胞內生理活性離子的濃度維持在低的狀態的效果時，此時的變動磁場發生裝置1的運作如以下所述。When the oscillation of the intracellular physiologically active ions in the vascular smooth muscle cells is suppressed in this way, and the effect of maintaining the concentration of the intracellular physiologically active ions in a low state is achieved, the operation of the variable magnetic field generator 1 at this time is as follows.

本發明的實施形態中的變動磁場發生裝置1中，沒有要求磁性體2的磁極一定要是異極。如上所述，藉由利用一個磁極所賦予的變動磁場所產生在使用者的體內各部的反應，會在利用下一個磁極賦予變動磁場前結束。從而，磁性體2的磁極可以是同極，也可以是異極。In the variable magnetic field generating device 1 in the embodiment of the present invention, the magnetic poles of the magnetic body 2 are not required to be different poles. As described above, the reaction in various parts of the user's body caused by the variable magnetic field imparted by one magnetic pole ends before the variable magnetic field is imparted by the next magnetic pole. Therefore, the magnetic poles of the magnetic body 2 may be the same pole or different poles.

又，藉由驅動部3對磁性體2所賦予的旋轉次數，例如是每分鐘旋轉500次以上。這是因為基於實驗的結果發現：藉由驅動部3使磁性體2以每分鐘旋轉500次以上的旋轉次數進行旋轉，可表現出抑制生理活性離子的振盪的效果。並且，進一步有關旋轉次數的上限，例如能夠設為每分鐘旋轉6500次。In addition, the number of rotations given to the magnetic body 2 by the drive unit 3 is, for example, 500 rotations per minute or more. This is because it has been found based on the results of experiments that the drive unit 3 rotates the magnetic body 2 at 500 or more rotations per minute to exhibit the effect of suppressing the oscillation of physiologically active ions. Furthermore, regarding the upper limit of the number of rotations, for example, it can be set to 6,500 rotations per minute.

同樣地，藉由驅動部3對磁屏蔽材料所賦予的旋轉次數，例如是每分鐘旋轉500次以上。Similarly, the number of rotations given to the magnetic shielding material by the drive unit 3 is, for example, 500 rotations per minute or more.

進一步，磁性體2被配置在盡量地接近使用者的皮膚S的位置。這是因為：磁性體2與變動磁場發生裝置1所貼附的皮膚S的距離越近，就能夠越確實地使賦予至使用者的體內各部的變動磁場的強度變強。具體而言，本發明的實施形態中的變動磁場發生裝置1中，磁性體2被配置在從變動磁場發生裝置1接觸使用者的皮膚S的面算起大約1mm～13mm之間的範圍內的位置(參照第1圖的符號H)。Furthermore, the magnetic body 2 is arranged at a position as close as possible to the skin S of the user. This is because the closer the distance between the magnetic body 2 and the skin S to which the fluctuating magnetic field generating device 1 is applied, the more surely the intensity of the fluctuating magnetic field applied to each part of the user's body can be increased. Specifically, in the fluctuating magnetic field generating device 1 in the embodiment of the present invention, the magnetic body 2 is arranged in a range of approximately 1 mm to 13 mm from the surface of the fluctuating magnetic field generating device 1 contacting the skin S of the user. Position (refer to symbol H in Figure 1).

根據以上說明的至少一個實施形態，本發明的實施形態中的變動磁場發生裝置1中，因為採用上述的構成，而能夠利用變動磁場來達到直接地抑制平滑肌的收縮，藉此去除因平滑肌進行收縮所產生的障礙。According to at least one embodiment described above, in the variable magnetic field generating device 1 in the embodiment of the present invention, because of the above-mentioned configuration, the variable magnetic field can be used to directly suppress the contraction of smooth muscle, thereby eliminating the contraction caused by the smooth muscle. The resulting obstacles.

藉由這樣地對血管平滑肌細胞賦予變動磁場，能夠妨礙想要使血管平滑肌細胞收縮的作用。從而，在賦予有變動磁場的狀態下，能夠維持血管舒張(擴張)而不會收縮的狀態。因此，血液循環會變好，並且能夠期待改善各式各樣的疾病的效果。By applying a variable magnetic field to the vascular smooth muscle cells in this way, it is possible to hinder the effect of contracting the vascular smooth muscle cells. Therefore, in the state where the variable magnetic field is applied, it is possible to maintain the state where the blood vessel is relaxed (expanded) without contracting. Therefore, blood circulation will be improved, and the effect of improving various diseases can be expected.

進一步，藉由賦予變動磁場，能夠表現出血管的收縮被抑制而舒張的狀態，這是因為，在賦予變動磁場的期間，能夠減少因任何原因所造成而發生的細胞內的生理活性離子的濃度暫時性地變高的現象。Furthermore, by applying a variable magnetic field, it is possible to express a state where the contraction of the blood vessel is suppressed and relax. This is because the concentration of physiologically active ions in the cell generated due to any reason can be reduced during the period when the variable magnetic field is applied. Temporarily high phenomenon.

(第二實施形態) 繼而，說明本發明中的第二實施形態。再者，在第二實施形態中，對於與已說明於上述的第一實施形態中的構成要素相同的構成要素，標示為相同的符號，並且為了避免重複說明，而省略相同的構成要素的說明。(Second Embodiment) Next, the second embodiment of the present invention will be described. Furthermore, in the second embodiment, the same constituent elements as those described in the first embodiment described above are denoted by the same symbols, and in order to avoid repetitive description, the description of the same constituent elements is omitted. .

[變動磁場發生裝置的構成] 第6圖是顯示第二實施形態中的變動磁場發生裝置11的整體構成的平面圖。又，第7圖是顯示第二實施形態中的變動磁場發生裝置11的第一變化例，也就是變動磁場發生裝置12的整體構成的平面圖。進一步，第8圖是顯示第二實施形態中的變動磁場發生裝置11的第二變化例，也就是變動磁場發生裝置13的整體構成的平面圖。[Constitution of Variable Magnetic Field Generator] Fig. 6 is a plan view showing the overall configuration of the variable magnetic field generating device 11 in the second embodiment. In addition, FIG. 7 is a plan view showing a first modification example of the variable magnetic field generating device 11 in the second embodiment, that is, the overall configuration of the variable magnetic field generating device 12. Furthermore, FIG. 8 is a plan view showing a second modification example of the fluctuating magnetic field generating device 11 in the second embodiment, that is, the overall configuration of the fluctuating magnetic field generating device 13.

第6圖～第8圖所示的第二實施形態中的變動磁場發生裝置11～變動磁場發生裝置13，可使用於例如將磁力直接對準經分離的細胞，藉此確認細胞內的生理活性離子振盪和鈣離子振盪反應的表現。因此，與上述第一實施形態中的變動磁場發生裝置1不同，不是貼附於使用者的皮膚S上來使用。The fluctuating magnetic field generating device 11 to the fluctuating magnetic field generating device 13 in the second embodiment shown in Figs. 6 to 8 can be used, for example, to directly aim a magnetic force on a separated cell, thereby confirming the physiological activity in the cell The performance of ion oscillation and calcium ion oscillation reaction. Therefore, unlike the fluctuating magnetic field generating device 1 in the first embodiment described above, it is not attached to the skin S of the user for use.

亦即，第二實施形態中的變動磁場發生裝置，例如可使用於以顯微鏡觀察被載置於已設置有載物台之腔室中的細胞的情況。更具體而言，在該等變動磁場發生裝置中容納作為觀察對象的細胞，並且將該變動磁場發生裝置固定於顯微鏡來進行觀察。That is, the fluctuating magnetic field generating device in the second embodiment can be used to observe, for example, the condition of the cells placed in the chamber where the stage is installed with a microscope. More specifically, cells to be observed are accommodated in the fluctuating magnetic field generating devices, and the fluctuating magnetic field generating device is fixed to a microscope for observation.

首先，在第6圖所示的變動磁場發生裝置11中，在矩形的殼體的大約中央部配置有載物台P1，其載置作為觀察對象的細胞。此處，載物台P1上設置有複數個容納細胞之腔室R。在第6圖所示的載物台P1上設有4個腔室R1～腔室R4。First, in the fluctuating magnetic field generator 11 shown in FIG. 6, a stage P1 is arranged at approximately the center of a rectangular casing, and the cell to be observed is placed on it. Here, a plurality of chambers R containing cells are provided on the stage P1. The stage P1 shown in FIG. 6 is provided with four chambers R1 to R4.

其中，載物台P1上可設置複數個腔室R，但是腔室的數量並未特別限定。再者，以下，彙整地說明各個腔室時，適當地表示為「腔室R」。Among them, a plurality of chambers R may be provided on the stage P1, but the number of chambers is not particularly limited. In addition, in the following, when each chamber is described collectively, it is appropriately represented as "chamber R".

載物台P1上，以屹立於板狀的底面上的方式設置有4個腔室，其例如是具有圓柱狀的形狀的腔室R1～R4。該腔室R1～腔室R4的內部中，容納有作為觀察對象的細胞。On the stage P1, four chambers are provided so as to stand on a plate-shaped bottom surface, and these are, for example, chambers R1 to R4 having a cylindrical shape. Inside the chamber R1 to chamber R4, cells to be observed are housed.

細胞雖然是以這樣的方式被容納在腔室R的內部來進行觀察，但是實際上被容納於腔室R中的細胞，在腔室R之中，是以大範圍且薄的方式進行分佈，並且以黏著在該底面的形態存在。因此，細胞被容納在腔室R中的狀態，以「細胞被載置於腔室中」來適當地表示。Although the cells are contained in the chamber R in this way for observation, the cells actually contained in the chamber R are distributed in a large and thin manner in the chamber R. And it exists in the form of sticking to the bottom surface. Therefore, the state in which the cells are contained in the chamber R is appropriately expressed as "the cells are placed in the chamber".

載物台P1，在觀察時被容納在變動磁場發生裝置11的內部。亦即，在變動磁場發生裝置11中，設有載物台P1的容納部11a。此處，配合外型被形成為圓形的載物台P1，容納部11a被形成為圓柱形。The stage P1 is housed in the fluctuating magnetic field generator 11 during observation. That is, in the variable magnetic field generating device 11, the accommodating portion 11a of the stage P1 is provided. Here, the mating shape is formed into a circular stage P1, and the receiving portion 11a is formed into a cylindrical shape.

再者，此處針對容納部11a中的載物台P1的固定方法並無特別限定。可以設為下述方式：藉由在載物台P1的底面與容納部11a之間使用任何的機構來連結而固定、或藉由將載物台P1的上表面朝垂直向下的方向壓入來將載物台P1固定於容納部11a內。In addition, the fixing method of the stage P1 in the accommodating part 11a here is not specifically limited. It can be set as follows: by using any mechanism to connect and fix between the bottom surface of the stage P1 and the accommodating portion 11a, or by pressing the upper surface of the stage P1 in a vertical downward direction To fix the stage P1 in the accommodating portion 11a.

在該容納部11a的側壁部分，可配置複數個磁性體21。亦即，當在該容納部11a載置有載物台P1時，該載物台P1的周圍會被磁性體21包圍。第6圖所示的變動磁場發生裝置11中，以互為正交的方式配置有4個磁性體21a～磁性體21d。A plurality of magnetic bodies 21 can be arranged in the side wall portion of the accommodating portion 11a. That is, when the stage P1 is placed on the accommodating portion 11 a, the periphery of the stage P1 is surrounded by the magnetic body 21. In the variable magnetic field generator 11 shown in FIG. 6, four magnetic bodies 21a to 21d are arranged so as to be orthogonal to each other.

雖然在此處如此地配置有4個磁性體21，但是沒有限制所配置的磁性體21的數量。例如，可配置2個或6個磁性體21，或者可使用1個圓環狀的磁性體21。又，當配置有複數個磁性體21時，也沒有限制其配置位置和N極、S極的差異。Although four magnetic bodies 21 are arranged in this manner, the number of magnetic bodies 21 arranged is not limited. For example, two or six magnetic bodies 21 may be arranged, or one annular magnetic body 21 may be used. In addition, when a plurality of magnetic bodies 21 are arranged, there is no restriction on the difference between the arrangement position and the N pole and S pole.

又，該4個磁性體21a～磁性體21d，可被容納於1個圓環狀的磁性體容納部11b中。因此，藉由該磁性體容納部11b進行旋轉，能夠使磁性體21a～磁性體21d一體性地移動。在第二實施形態中的變動磁場發生裝置11中，採用以下的構成來作為使磁性體容納部11b旋轉的構成。In addition, the four magnetic bodies 21a to 21d can be accommodated in one annular magnetic body accommodating portion 11b. Therefore, the magnetic body 21a to the magnetic body 21d can be moved integrally by the rotation of the magnetic body accommodating portion 11b. In the variable magnetic field generating device 11 in the second embodiment, the following configuration is adopted as the configuration for rotating the magnetic body accommodating portion 11b.

亦即，在該磁性體容納部11b的上表面，以沿著其圓周的圓周狀的方式設有齒輪11c。該齒輪11c嚙合於與驅動部31連結並傳遞該驅動部的旋轉之齒輪，而能夠承受來自驅動部31的驅動力。因此，磁性體容納部11b能夠承受驅動部31的動力來進行旋轉。That is, on the upper surface of the magnetic body accommodating portion 11b, a gear 11c is provided in a circumferential manner along the circumference thereof. The gear 11c meshes with a gear that is connected to the driving part 31 and transmits the rotation of the driving part, and can receive the driving force from the driving part 31. Therefore, the magnetic body accommodating portion 11b can receive the power of the driving portion 31 to rotate.

藉由此運作，複數個磁性體21a～磁性體21d，以垂直地貫穿細胞的載置面的軸作為旋轉軸，並在與載置面平行的面上，在被載置於腔室R1～腔室R4中的細胞周圍進行移動，而能夠對細胞賦予變動磁場。By this operation, the plurality of magnetic bodies 21a to 21d are placed in the chambers R1 to R1 to the chambers R1 to R1 to the chambers R1 to R1 to the chambers R1 to The cells in the chamber R4 move around, and a variable magnetic field can be applied to the cells.

再者，在本發明的實施形態的變動磁場發生裝置11中，雖然是如此地在磁性體容納部11b中直接地設有齒輪11c，但是只要磁性體容納部11b能夠承受來自驅動部31的驅動力，並能夠圍繞細胞的周圍進行旋轉而對細胞賦予變動磁場即可，而未對其構造進行限定。Furthermore, in the variable magnetic field generating device 11 of the embodiment of the present invention, although the gear 11c is directly provided in the magnetic body accommodating portion 11b in this way, as long as the magnetic body accommodating portion 11b can withstand the drive from the driving portion 31 It is sufficient if it can rotate around the cell and apply a variable magnetic field to the cell, and its structure is not limited.

繼而，針對上述的變動磁場發生裝置11的變化例，舉例第7圖所示的變動磁場發生裝置12來說明。第一變化例也就是變動磁場發生裝置12，從磁性體承受來自驅動部的驅動力而圍繞細胞的周圍進行旋轉並藉此對細胞賦予變動磁場這點來看，與變動磁場發生裝置11相同，但是其構造卻不同。Next, with respect to a modification example of the above-mentioned fluctuating magnetic field generating device 11, the fluctuating magnetic field generating device 12 shown in FIG. 7 will be described as an example. The first modified example is the variable magnetic field generating device 12, which is the same as the variable magnetic field generating device 11 in that the magnetic body receives the driving force from the drive unit and rotates around the cell, thereby applying a variable magnetic field to the cell. But its structure is different.

亦即，首先，使用於變動磁場發生裝置12的載物台P2，僅設有1個腔室R5。該腔室R5被設在載物台P2的中央部，而在其中容納(載置)作為觀察對象的細胞。That is, first, the stage P2 used in the variable magnetic field generating device 12 is provided with only one chamber R5. The chamber R5 is provided in the center of the stage P2, and accommodates (places) cells to be observed therein.

該腔室R5的構造本身，與被設置於上述的載物台P1的腔室R1～腔室R4相同。但是，載物台P2僅具備1個腔室R5，並且其配置位置在中央部這點上，與被設置於載物台P1的腔室R1～腔室R4不同。又，因為在載物台P2上是採用這樣的構成，所以變得能夠確保在該腔室R5的側壁與載物台P2的周緣之間的空間。The structure itself of the chamber R5 is the same as the chamber R1 to the chamber R4 provided on the stage P1 described above. However, the stage P2 is equipped with only one chamber R5, and its arrangement position is different from the chambers R1 to R4 provided on the stage P1 in that the arrangement position is at the center. In addition, since such a configuration is adopted for the stage P2, it becomes possible to ensure a space between the side wall of the chamber R5 and the peripheral edge of the stage P2.

並且，該空間可被利用來作為容納磁性體之空間。變動磁場發生裝置12中，如第7圖中以虛線所示的那樣，4個磁性體21e～磁性體21h以互為正交的方式被配置在腔室R5的周圍。In addition, this space can be used as a space for accommodating magnetic bodies. In the variable magnetic field generating device 12, as shown by a broken line in FIG. 7, the four magnetic bodies 21e to 21h are arranged so as to be orthogonal to each other around the cavity R5.

並且，第一變化例中，因為可這樣地確保在腔室R5的側壁與載物台P2的周緣之間的空間，所以用於變動磁場發生裝置12中的磁性體21e～磁性體21h，可使用比用於上述的變動磁場發生裝置11中的磁性體21a～磁性體21d更大的磁性體。因為能夠利用這樣大的磁性體，所以比起變動磁場發生裝置11，變動磁場發生裝置12能夠對細胞施加更大的磁力。In addition, in the first modification example, since the space between the side wall of the chamber R5 and the periphery of the stage P2 can be secured in this way, the magnetic body 21e to the magnetic body 21h in the variable magnetic field generating device 12 can be used. A magnetic body larger than the magnetic body 21a to the magnetic body 21d used in the above-mentioned fluctuating magnetic field generator 11 is used. Since such a large magnetic body can be used, the fluctuating magnetic field generator 12 can apply a larger magnetic force to cells than the fluctuating magnetic field generator 11.

再者，雖然在變動磁場發生裝置12中，4個磁性體21e～磁性體21h被配置在腔室R5的周圍，但是磁性體的數量、配置位置或N極、S極的選擇仍能夠自由設定。Furthermore, although the four magnetic bodies 21e to 21h are arranged around the chamber R5 in the variable magnetic field generator 12, the number and arrangement position of the magnetic bodies or the selection of N pole and S pole can still be freely set .

又，變動磁場發生裝置11中，被設置在變動磁場發生裝置11中的磁性體容納部11b內，已容納有4個磁性體21a～磁性體21d。另一方面，在變動磁場發生裝置12中的磁性體21e～磁性體21h，因為比變動磁場發生裝置11中的磁性體21a～磁性體21d更大，所以基於載物台P2的形狀、尺寸與配置位置的關係，磁性體21e～磁性體21h是以從載物台P2的上部覆蓋這樣的形態來配置。In addition, in the variable magnetic field generating device 11, the four magnetic bodies 21a to 21d are already housed in the magnetic body accommodating portion 11b provided in the variable magnetic field generating device 11. On the other hand, the magnetic bodies 21e to 21h in the fluctuating magnetic field generating device 12 are larger than the magnetic bodies 21a to 21d in the fluctuating magnetic field generating device 11. Therefore, they are based on the shape, size, and size of the stage P2. Regarding the arrangement position, the magnetic body 21e to the magnetic body 21h are arranged in a form of covering from the upper part of the stage P2.

亦即，使用變動磁場發生裝置12來實行細胞的觀察時，首先，設置有腔室R5之載物台P2被載置於變動磁場發生裝置12的容納部12a內，該腔室R5載置有細胞。被設置在載物台P2上的腔室R5，因為被設置在載物台P2的中央部，所以變得能夠在其與容納部12a的側壁之間形成空間。That is, when using the fluctuating magnetic field generator 12 to observe cells, first, the stage P2 provided with the chamber R5 is placed in the accommodating portion 12a of the fluctuating magnetic field generator 12, and the chamber R5 is placed cell. Since the chamber R5 provided on the stage P2 is provided at the center of the stage P2, it becomes possible to form a space between the chamber R5 and the side wall of the accommodating portion 12a.

雖然如上所述會變得可在該空間內配置有磁性體21e～磁性體21h，但是首先會因為將載物台P2載置於容納部12a中的關係，而無法從一開始就預先配置在該位置上。因此，容納有磁性體21e～磁性體21h之磁性體容納部12b，是以從載物台P2的上部覆蓋的形態被配置在容納部12a內。Although it becomes possible to arrange the magnetic body 21e to the magnetic body 21h in this space as described above, first of all, because the stage P2 is placed in the accommodating portion 12a, it cannot be pre-arranged in the first place. That location. Therefore, the magnetic body accommodating part 12b which accommodates the magnetic body 21e-21h is arrange|positioned in the accommodating part 12a in the form of covering from the upper part of the stage P2.

再者，此處，被配置在容納部12a內的磁性體容納部12b，可使用螺栓等來固定於變動磁場發生裝置12。但是，針對磁性體容納部12b的固定方法，能夠採用各式各樣的固定方法，而並未限定於此種固定方法。In addition, here, the magnetic body accommodating part 12b arrange|positioned in the accommodating part 12a can be fixed to the fluctuating magnetic field generator 12 using a bolt etc. However, as for the fixing method of the magnetic body accommodating part 12b, various fixing methods can be adopted, and it is not limited to such a fixing method.

由於是這樣地以覆蓋載物台P2的形態來將磁性體容納部12b配置於容納部12a，所以認為會因為磁性體容納部12b所採用的形狀，而變得無法觀察被載置於腔室R5內的細胞。因此，在變動磁場發生裝置12中的磁性體容納部12b的中央部，設置有貫穿孔12c。藉由設置該貫穿孔12c，而能夠以顯微鏡來觀察被載置於腔室R5內的細胞，該腔室R5被設置在載物台P2的中央部。Since the magnetic accommodating portion 12b is arranged in the accommodating portion 12a in such a manner as to cover the stage P2, it is thought that the shape of the magnetic accommodating portion 12b may make it impossible to observe the placement in the cavity. Cells within R5. Therefore, a through hole 12c is provided in the central part of the magnetic body housing part 12b in the variable magnetic field generating device 12. By providing the through hole 12c, the cells placed in the chamber R5 can be observed with a microscope, and the chamber R5 is provided at the center of the stage P2.

並且，該磁性體容納部12b，作成能夠圍繞載物台P2的腔室R5的周圍進行旋轉。在變動磁場發生裝置12中，在磁性體容納部12b的周圍設有齒輪12d，並且該齒輪12d嚙合於與驅動部31連結的齒輪，而能夠承受來自驅動部31的驅動力。In addition, the magnetic body accommodating portion 12b is made to be rotatable around the cavity R5 of the stage P2. In the variable magnetic field generating device 12, a gear 12 d is provided around the magnetic body accommodating portion 12 b, and the gear 12 d is meshed with a gear connected to the driving portion 31 and can receive the driving force from the driving portion 31.

因此，磁性體容納部12b會承受驅動部31的動力而旋轉。藉由該運作，磁性體21e～磁性體21h能夠圍繞已載置有細胞之腔室R5的周圍進行旋轉而對細胞賦予變動磁場。Therefore, the magnetic body accommodating part 12b receives the power of the driving part 31 and rotates. With this operation, the magnetic body 21e to the magnetic body 21h can rotate around the chamber R5 in which the cells have been placed, thereby imparting a variable magnetic field to the cells.

再者，被設置於磁性體容納部12b的周圍之齒輪12d，被形成為比被設置於變動磁場發生裝置11的磁性體容納部11b的齒輪11c更寬闊。這是因為，用於變動磁場發生裝置12的磁性體21e～磁性體21h，比起用於變動磁場發生裝置11的磁性體21a～磁性體21d更大，所以為了使容納有該等磁性體之磁性體容納部12b旋轉，需要更大的驅動力所致。Furthermore, the gear 12 d provided around the magnetic body housing portion 12 b is formed to be wider than the gear 11 c provided on the magnetic body housing portion 11 b of the variable magnetic field generating device 11. This is because the magnetic bodies 21e to 21h used in the variable magnetic field generating device 12 are larger than the magnetic bodies 21a to 21d used in the variable magnetic field generating device 11. The rotation of the body accommodating portion 12b requires a larger driving force.

繼而，針對上述的變動磁場發生裝置11的第二變化例，舉例第8圖所示的變動磁場發生裝置13來說明。第二變化例也就是變動磁場發生裝置13，從磁性體承受來自驅動部的驅動力而旋轉並藉此對細胞賦予變動磁場這點來看，與變動磁場發生裝置11和變動磁場發生裝置12相同，但是其構造和磁性體的旋轉方法卻不同。Next, for the second modification example of the above-mentioned fluctuating magnetic field generating device 11, the fluctuating magnetic field generating device 13 shown in FIG. 8 will be described as an example. The second modified example is the variable magnetic field generating device 13, which is the same as the variable magnetic field generating device 11 and the variable magnetic field generating device 12 from the point that the magnetic body rotates under the driving force from the driving part to apply a variable magnetic field to the cells. , But its structure and the rotation method of the magnetic body are different.

用於變動磁場發生裝置13的載物台P3，與載物台P2相同，其在中央部具備1個腔室R6。該腔室R6的內部中載置有作為觀察對象的細胞。The stage P3 used for the variable magnetic field generating device 13 is the same as the stage P2, and is provided with one chamber R6 in the center. Cells to be observed are placed in the chamber R6.

另一方面，變動磁場發生裝置13的磁性體的配置位置與旋轉的方向卻與目前為止說明的變動磁場發生裝置11和變動磁場發生裝置12不同。亦即，用於變動磁場發生裝置13的磁性體21i和磁性體21j，是以如第8圖所示的那樣地被配置成夾持已載置有細胞之腔室R6且位於相互地相對向的位置。也就是說，變動磁場發生裝置13的磁性體與使用於變動磁場發生裝置11和變動磁場發生裝置12的磁性體不同，不是以磁性體圍繞細胞的周圍進行旋轉來賦予變動磁場者。On the other hand, the arrangement position and the direction of rotation of the magnetic body of the variable magnetic field generating device 13 are different from those of the variable magnetic field generating device 11 and the variable magnetic field generating device 12 described so far. That is, the magnetic body 21i and the magnetic body 21j used for the variable magnetic field generating device 13 are arranged so as to sandwich the chamber R6 in which the cells are placed as shown in FIG. 8 and are located opposite to each other. s position. In other words, the magnetic body of the variable magnetic field generating device 13 is different from the magnetic body used in the variable magnetic field generating device 11 and the variable magnetic field generating device 12 in that the magnetic body is not applied to the variable magnetic field by rotating the magnetic body around the cell.

第二變化例中的磁性體21i和磁性體21j，將其旋轉軸各自設為磁性體21i和磁性體21j的長度方向的軸。從而，磁性體21i和磁性體21j不會移動其位置，而是在其配置位置上以長度方向的軸作為旋轉軸來進行旋轉，並不會圍繞細胞的周圍進行旋轉。In the magnetic body 21i and the magnetic body 21j in the second modification example, the rotation axis of the magnetic body 21i and the magnetic body 21j are each set to the longitudinal axis of the magnetic body 21i and the magnetic body 21j. Therefore, the magnetic body 21i and the magnetic body 21j do not move their positions, but rotate with the longitudinal axis as the rotation axis in their arrangement positions, and do not rotate around the cell.

如上所述，磁性體21i和磁性體21j，被配置成將腔室R6夾持在該兩者之間且位於相對向的位置。並且，當將第二變化例中的變動磁場發生裝置13中的磁性體21i，在寬度方向上切斷來觀察其剖面時，作為其中一例，例如可列舉上半部是N極且下半部是S極的情況。As described above, the magnetic body 21i and the magnetic body 21j are arranged so as to sandwich the cavity R6 between the two and to be located in opposing positions. Furthermore, when the magnetic body 21i in the variable magnetic field generating device 13 in the second modification is cut in the width direction to observe its cross section, as an example, for example, the upper half is N-pole and the lower half is It is the case of S pole.

亦即，在該情況下，以通過長度方向的旋轉軸的方式切斷時，上半部是N極且下半部是S極。並且，當磁性體21i在該狀態下，位於夾持腔室R6且相對向的位置的磁性體21j，是以下半部是N極且下半部是S極的方式來配置。也就是說，磁性體21i和磁性體21j在夾持腔室R6而相向時呈現異極相互地相向的形態。That is, in this case, when it is cut so as to pass through the rotating shaft in the longitudinal direction, the upper half is the N pole and the lower half is the S pole. In addition, when the magnetic body 21i is in this state, the magnetic body 21j located at a position facing the cavity R6 is arranged such that the lower half is the N pole and the lower half is the S pole. That is, when the magnetic body 21i and the magnetic body 21j face each other with the cavity R6 sandwiched therebetween, the different poles face each other.

再者，有關磁性體21i和磁性體21j中的N極、S極的配置，除了上述這樣地上下半部分別為N極和S極地互相配置的情況以外，例如，當在寬度方向切斷來觀察其剖面時，也可利用以N極和S極在圓周方向相互地不同的方式來配置，並且其配置位置並無特別限定。又，也可以是磁性體21i和磁性體21j在夾持腔室R6且相向時呈現同極相互地相向的形態。In addition, regarding the arrangement of the N pole and S pole in the magnetic body 21i and the magnetic body 21j, except for the above-mentioned case where the upper and lower halves are respectively arranged with the N pole and the S pole, for example, when cut in the width direction When observing the cross section, the N pole and the S pole may be arranged so that they are different from each other in the circumferential direction, and the arrangement position is not particularly limited. In addition, the magnetic body 21i and the magnetic body 21j may be in a form in which the same poles face each other when facing each other while sandwiching the cavity R6.

此處，第二變化例的變動磁場發生裝置13中，以驅動力可分別傳遞至磁性體21i和磁性體21j的方式來構成驅動部31，該磁性體21i和磁性體21j位於夾持腔室R6且相對向的位置。亦即，在變動磁場發生裝置13中，驅動部31是由第一驅動部331與第二驅動部312所構成，該第一驅動部311用以驅動磁性體21i，該第二驅動部312用以驅動磁性體21j。Here, in the variable magnetic field generating device 13 of the second modification example, the driving portion 31 is configured such that the driving force can be transmitted to the magnetic body 21i and the magnetic body 21j, which are located in the clamping chamber. R6 and opposite position. That is, in the variable magnetic field generating device 13, the driving part 31 is composed of a first driving part 331 and a second driving part 312. The first driving part 311 is used to drive the magnetic body 21i, and the second driving part 312 is used to drive the magnetic body 21i. To drive the magnetic body 21j.

其中，作為施加旋轉之機構，可以如第8圖所示僅設置1個，來自該1個機構的驅動力會經由貫穿第一驅動部311和第二區動部312之傳動裝置，傳遞至磁性體21i和磁性體21j。因為變動磁場發生裝置13具備這樣的構造，所以磁性體21i和磁性體21j藉由來自驅動部31的驅動力會往相同方向旋轉。Among them, as a mechanism for applying rotation, only one mechanism can be provided as shown in Figure 8. The driving force from this mechanism will be transmitted to the magnetic through the transmission device penetrating the first driving part 311 and the second zone moving part 312 The body 21i and the magnetic body 21j. Since the variable magnetic field generating device 13 has such a structure, the magnetic body 21i and the magnetic body 21j are rotated in the same direction by the driving force from the driving unit 31.

依照該方式，磁性體21i和磁性體21j會被配置在夾持細胞且相互地相對向的位置，所以相對於被載置於腔室R6內的細胞，能夠以與細胞的載置面平行的軸也就是磁性體21i和磁性體21j所共有的軸作為旋轉軸來進行旋轉。According to this method, the magnetic body 21i and the magnetic body 21j are arranged at positions facing each other while sandwiching the cells. Therefore, the cells placed in the chamber R6 can be placed parallel to the cell placement surface. The axis, that is, the axis shared by the magnetic body 21i and the magnetic body 21j, rotates as a rotation axis.

並且，當該等磁性體21i和磁性體21j夾持腔室R6且相對向時，可利用異極相互地相向的方式來配置。並且藉由該等配置，能夠對被載置於腔室R6內的細胞更有效地施加變動磁場。In addition, when the magnetic body 21i and the magnetic body 21j face each other while sandwiching the cavity R6, they can be arranged in such a way that the opposite poles face each other. Moreover, with these arrangements, the variable magnetic field can be applied more effectively to the cells placed in the chamber R6.

再者，如此地在變化例2中的磁性體21i和磁性體21j，以異極相互地相向的形態來配置，但是也可以採用下述磁性體來配置，例如：同極相向的形態、或其中一磁性體為N極而與其相對向的磁性體為S極者。Furthermore, the magnetic body 21i and the magnetic body 21j in Modification 2 are arranged in such a manner that the opposite poles face each other, but the following magnetic bodies may also be used, for example, the form of the same poles facing each other, or One of the magnetic bodies is the N pole and the opposite magnetic body is the S pole.

又，變動磁場發生裝置13中的磁性體21i和磁性體21j，其一部分被磁性體蓋板22覆蓋。磁性體21i和磁性體21j，如上述那樣地以其長度方向作為旋轉軸進行旋轉。但是，因為磁性體21i和磁性體21j具有一定程度的重量，所以認為磁性體21i和磁性體21j可能會由於自身的重量而造成旋轉軸偏移。因為認為若旋轉軸偏移，磁性體21i和磁性體21j會與周圍的構造物接觸，所以作成以磁性體蓋板22來維持旋轉軸的形態。In addition, part of the magnetic body 21i and the magnetic body 21j in the variable magnetic field generating device 13 are covered by the magnetic body cover 22. The magnetic body 21i and the magnetic body 21j rotate with the longitudinal direction as the rotation axis as described above. However, since the magnetic body 21i and the magnetic body 21j have a certain degree of weight, it is considered that the magnetic body 21i and the magnetic body 21j may cause the rotation axis to shift due to their own weight. It is considered that if the rotation axis is shifted, the magnetic body 21i and the magnetic body 21j will come into contact with surrounding structures, so the magnetic body cover 22 is made to maintain the shape of the rotation axis.

又，可能會由於磁性體21i和磁性體21j的磁力的強度，對周圍的機構造成影響。因此，藉由設為磁性體蓋板22各自覆蓋磁性體21i和磁性體21j的形態，能夠使磁力的影響不會波及其他的機構。In addition, the strength of the magnetic force of the magnetic body 21i and the magnetic body 21j may affect the surrounding mechanisms. Therefore, by setting the magnetic body cover 22 to each cover the magnetic body 21i and the magnetic body 21j, it is possible to prevent the influence of the magnetic force from spreading to other mechanisms.

再者，作為第二實施形態中的變動磁場發生裝置中的驅動部31，認為例如可以是馬達或螺旋彈簧這樣的機構，並且這樣的驅動部31已說明於第一實施形態。進一步，變動磁場發生裝置11～變動磁場發生裝置13中的驅動部31的配置位置僅為例示，其配置位置能夠設為任意的位置。In addition, as the driving part 31 in the fluctuating magnetic field generating device in the second embodiment, it is considered that a mechanism such as a motor or a coil spring may be used, and such a driving part 31 has been described in the first embodiment. Furthermore, the arrangement position of the drive unit 31 in the variable magnetic field generating device 11 to the variable magnetic field generating device 13 is only an example, and the arrangement position can be set to any position.

有關殼體4的形狀，只要可形成為能夠容納在其中移動的磁性體2之內部空間即可，例如可形成為任何形狀，例如：大約圓柱狀、大約多角柱狀。又，殼體4的成形材料並無特別限定，只要在承受來自外部的力時能夠維持內部空間的形狀即可。Regarding the shape of the housing 4, as long as it can be formed into an internal space capable of accommodating the moving magnetic body 2 therein, for example, it can be formed in any shape, for example, approximately cylindrical shape or approximately polygonal column shape. In addition, the molding material of the housing 4 is not particularly limited, as long as it can maintain the shape of the internal space when receiving a force from the outside.

如同以上的說明，本發明的實施形態中的變動磁場發生裝置11～變動磁場發生裝置13，採用了上述的構成，所以例如能夠將磁力直接對準經分離的細胞，藉此確認細胞內的生理活性離子振盪和鈣離子振盪反應的表現。As described above, the fluctuating magnetic field generator 11 to the fluctuating magnetic field generator 13 in the embodiment of the present invention adopt the above-mentioned structure, so for example, it is possible to directly aim the magnetic force on the separated cells, thereby confirming the physiology of the cells. The performance of active ion oscillation and calcium ion oscillation reaction.

本說明書中說明了本發明的數個實施形態，但是該等實施形態僅是作為例子加以列舉，並非用以限定本發明的範圍。該等實施形態能夠以其他各式各樣的形態來實施，並且在不脫離本發明的要旨的範圍內，能夠實行各種的省略、置換及變更。該等實施形態和其變化，只要被包含在本發明的範圍和要旨內，也同樣地被包含在申請專利範圍所述之發明及與其均等的範圍內。In this specification, several embodiments of the present invention have been described, but these embodiments are only listed as examples and are not intended to limit the scope of the present invention. These embodiments can be implemented in various other forms, and various omissions, substitutions, and changes can be made within the scope not departing from the gist of the present invention. As long as these embodiments and their changes are included in the scope and gist of the present invention, they are also included in the invention described in the scope of the patent application and the scope equivalent thereto.

1:變動磁場發生裝置 2:磁性體 3:驅動部 4:殼體 5:軸 11~13:變動磁場發生裝置 21:磁性體 H:磁性體與從變動磁場發生裝置接觸使用者的皮膚的面算起的距離 R:腔室 S:皮膚 2A~2C:磁性體 2C1:磁性流體 2C2:泵 2C3:循環管路 11a:容納部 11b:磁性體容納部 11c:齒輪 12a~12d: 21a~21j:磁性體 22:磁性體蓋板 31:驅動部 311:第一驅動部 312:第二驅動部 R1~R6:腔室 P1~P3:載物台 N:N極 S:S極1: Variable magnetic field generator 2: magnetic body 3: drive part 4: shell 5: axis 11~13: Variable magnetic field generator 21: Magnetic H: The distance between the magnetic body and the surface of the user's skin contacted by the variable magnetic field generator R: Chamber S: skin 2A~2C: Magnetic body 2C1: Magnetic fluid 2C2: Pump 2C3: Circulation pipeline 11a: Receptacle 11b: Magnetic body accommodating part 11c: Gear 12a~12d: 21a~21j: Magnetic body 22: Magnetic body cover 31: Drive 311: The first drive part 312: Second Drive R1~R6: Chamber P1~P3: Stage N: N pole S: S pole

第1圖是顯示第一實施形態中的變動磁場發生裝置的整體構成的剖面圖。 第2圖是顯示第一實施形態中的磁性體的一例的示意圖。 第3圖是顯示第一實施形態中的磁性體的一例的示意圖。 第4圖是顯示第一實施形態中的磁性體的一例的示意圖。 第5圖是顯示使用第一實施形態中的變動磁場發生裝置，對使用者賦予變動磁場時的效果的波形圖。 第6圖是顯示第二實施形態中的變動磁場發生裝置的整體構成的平面圖。 第7圖是顯示第二實施形態中的變動磁場發生裝置的第一變化例的變動磁場發生裝置的整體構成的平面圖。 第8圖是顯示第二實施形態中的變動磁場發生裝置的第二變化例的變動磁場發生裝置的整體構成的平面圖。Fig. 1 is a cross-sectional view showing the overall configuration of the variable magnetic field generating device in the first embodiment. Fig. 2 is a schematic diagram showing an example of the magnetic body in the first embodiment. Fig. 3 is a schematic diagram showing an example of the magnetic body in the first embodiment. Fig. 4 is a schematic diagram showing an example of the magnetic body in the first embodiment. Fig. 5 is a waveform diagram showing the effect of applying a variable magnetic field to the user by using the variable magnetic field generating device in the first embodiment. Fig. 6 is a plan view showing the overall configuration of the variable magnetic field generating device in the second embodiment. Fig. 7 is a plan view showing the overall configuration of the fluctuating magnetic field generating device as a first modification of the fluctuating magnetic field generating device in the second embodiment. Fig. 8 is a plan view showing the overall configuration of a fluctuating magnetic field generating device according to a second modification of the fluctuating magnetic field generating device in the second embodiment.

國內寄存資訊(請依寄存機構、日期、號碼順序註記) 無 國外寄存資訊(請依寄存國家、機構、日期、號碼順序註記) 無Domestic deposit information (please note in the order of deposit institution, date and number) without Foreign hosting information (please note in the order of hosting country, institution, date, and number) without

1:變動磁場發生裝置 1: Variable magnetic field generator

2:磁性體 2: magnetic body

3:驅動部 3: drive part

4:殼體 4: shell

5:軸 5: axis

H:磁性體與從變動磁場發生裝置接觸使用者的皮膚的面算起的距離 H: The distance between the magnetic body and the surface of the user's skin contacted by the variable magnetic field generator

S:皮膚 S: skin

Claims (17)

一種變動磁場發生裝置，其特徵在於，具備： 磁性體； 驅動部，其藉由使前述磁性體移動來使變動磁場發生；及， 殼體，其容納有前述磁性體與前述驅動部； 並且，該變動磁場發生裝置，藉由所發生的前述變動磁場來使細胞內的生理活性離子的振盪降低。A fluctuating magnetic field generating device, characterized in that it has: Magnetic A driving part, which generates a fluctuating magnetic field by moving the aforementioned magnetic body; and, A housing containing the aforementioned magnetic body and the aforementioned driving part; In addition, the fluctuating magnetic field generating device reduces the oscillation of physiologically active ions in the cell by the generated fluctuating magnetic field. 如請求項1所述之變動磁場發生裝置，其中，前述生理活性離子是鈣離子。The variable magnetic field generating device according to claim 1, wherein the physiologically active ion is calcium ion. 如請求項1或2所述之變動磁場發生裝置，其中，前述細胞是平滑肌細胞或間葉細胞。The variable magnetic field generating device according to claim 1 or 2, wherein the aforementioned cells are smooth muscle cells or mesenchymal cells. 如請求項1～3中任一項所述之變動磁場發生裝置，其中，前述磁性體所具備的複數個磁性部分的磁極，皆為相同的磁極方向。The variable magnetic field generating device according to any one of claims 1 to 3, wherein the magnetic poles of the plurality of magnetic parts included in the magnetic body are all in the same magnetic pole direction. 如請求項1～3中任一項所述之變動磁場發生裝置，其中，前述磁性體具備表現相互地不同的複數個磁極方向的磁性部分。The variable magnetic field generating device according to any one of claims 1 to 3, wherein the magnetic body includes a magnetic portion that expresses a plurality of magnetic pole directions different from each other. 如請求項1～5中任一項所述之變動磁場發生裝置，其中，前述磁性體具有流動性，前述驅動部藉由使前述磁性體以在環繞回路中循環的方式移動，來使前述變動磁場發生。The fluctuating magnetic field generating device according to any one of claims 1 to 5, wherein the magnetic body has fluidity, and the driving unit moves the magnetic body in a circular loop to cause the fluctuation The magnetic field occurs. 一種變動磁場發生裝置，其特徵在於，具備： 磁性體； 磁屏蔽材料，其部分地遮蔽前述磁性體的磁力； 驅動部，其使前述磁屏蔽材料旋轉；及， 殼體，其容納前述磁性體、前述磁屏蔽材料及前述驅動部； 並且，在前述磁性體被固定時，前述驅動部藉由使前述磁屏蔽材料旋轉來使變動磁場發生。A fluctuating magnetic field generating device, characterized in that it has: Magnetic Magnetic shielding material, which partially shields the magnetic force of the aforementioned magnetic body; A driving part that rotates the aforementioned magnetic shielding material; and, A housing containing the aforementioned magnetic body, the aforementioned magnetic shielding material, and the aforementioned driving part; In addition, when the magnetic body is fixed, the drive unit rotates the magnetic shielding material to generate a fluctuating magnetic field. 如請求項7所述之變動磁場發生裝置，其中，前述磁屏蔽材料具備前述變動磁場可通過的間隙。The variable magnetic field generating device according to claim 7, wherein the magnetic shielding material has a gap through which the variable magnetic field can pass. 如請求項7所述之變動磁場發生裝置，其中，前述磁屏蔽材料，其一部分具備由磁屏蔽性低的材料所構成的部位。The variable magnetic field generating device according to claim 7, wherein a part of the magnetic shielding material includes a portion made of a material with low magnetic shielding properties. 如請求項7～9中任一項所述之變動磁場發生裝置，其中，前述驅動部使前述磁屏蔽材料以每分鐘旋轉500次以上的旋轉速度進行旋轉。The variable magnetic field generating device according to any one of claims 7 to 9, wherein the drive unit rotates the magnetic shielding material at a rotation speed of 500 times or more per minute. 如請求項1～10中任一項所述之變動磁場發生裝置，其中，前述磁性體被配置在從安裝有前述變動磁場發生裝置之對象算起13mm以內的位置。The fluctuating magnetic field generating device according to any one of claims 1 to 10, wherein the magnetic body is arranged at a position within 13 mm from an object on which the fluctuating magnetic field generating device is installed. 如請求項1～5中任一項所述之變動磁場發生裝置，其中，進一步具備載物台，該載物台上具有載置前述細胞之腔室； 並且，前述磁性體，以垂直地貫穿於載置面的軸作為旋轉軸，並在與前述載置面平行的面上，在被載置於前述腔室中的前述細胞周圍進行移動。The variable magnetic field generating device according to any one of claims 1 to 5, further comprising a stage having a chamber for placing the aforementioned cells on the stage; In addition, the magnetic body uses an axis perpendicularly penetrating the mounting surface as a rotation axis, and moves on a surface parallel to the mounting surface around the cells mounted in the chamber. 如請求項12所述之變動磁場發生裝置，其中，在前述載物台上設置有單數個或複數個前述腔室。The variable magnetic field generating device according to claim 12, wherein a singular or plural chambers are provided on the stage. 如請求項1～5中任一項所述之變動磁場發生裝置，其中，進一步具備載物台，該載物台上具有載置前述細胞之腔室； 並且，複數個前述磁性體，被配置在夾持前述細胞且相互地相對向的位置，且相對於被載置於前述腔室中的前述細胞，以與載置面平行的軸也就是複數個前述磁性體所共有的軸作為旋轉軸來進行旋轉。The variable magnetic field generating device according to any one of claims 1 to 5, further comprising a stage having a chamber for placing the aforementioned cells on the stage; In addition, a plurality of the magnetic bodies are arranged at positions facing each other while sandwiching the cells, and with respect to the cells placed in the chamber, the plurality of magnetic bodies are arranged on an axis parallel to the placement surface. The axis shared by the aforementioned magnetic bodies is used as a rotation axis to rotate. 如請求項14所述之變動磁場發生裝置，其中，複數個前述磁性體皆朝相同方向旋轉。The variable magnetic field generating device according to claim 14, wherein the plurality of the aforementioned magnetic bodies all rotate in the same direction. 如請求項14或15所述之變動磁場發生裝置，其中，在前述載物台上設有1個前述腔室。The variable magnetic field generating device according to claim 14 or 15, wherein one chamber is provided on the stage. 如請求項1～6、12～16中任一項所述之變動磁場發生裝置，其中，當前述磁性體藉由前述驅動部而以能夠旋轉的方式來構成時，前述驅動部使前述磁性體以每分鐘旋轉500次以上的旋轉速度進行旋轉。The variable magnetic field generating device according to any one of claims 1 to 6, 12 to 16, wherein, when the magnetic body is configured to be rotatable by the driving part, the driving part causes the magnetic body to Rotate at a rotation speed of more than 500 rotations per minute.

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