TW201936121A - Systems and methods for simultaneous multi-focus ultrasound therapy in multiple dimensions - Google Patents
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Abstract
Description
本發明的若干實施例涉及基於能量的非侵入性治療，用於通過將能量同時或幾乎同時地遞送到皮膚表面下的組織的多個維度（例如，深度、高度、寬度、間隔、取向、放置）而在人臉、頭部、頸部和/或身體的皮膚和/或皮膚附近的組織上獲得美學和/或美容增強效果。
通過引用合併 Several embodiments of the present invention relate to energy-based non-invasive treatments for delivering energy to multiple dimensions (eg, depth, height, width, spacing, orientation, placement) of tissue beneath the skin surface simultaneously or nearly simultaneously ) While obtaining aesthetic and / or cosmetic enhancement effects on the skin of the human face, head, neck and / or body and / or tissues near the skin.
Merge by reference
2018年1月26日提交的美國臨時專利申請案第62/622,394號的全部內容為了所有目的通過引用併入本文。The entire contents of US Provisional Patent Application No. 62 / 622,394 filed on January 26, 2018 are incorporated herein by reference for all purposes.
一些美容程序涉及可能需要侵入性手術的侵入性程序。患者不僅需要忍受數周的恢復時間，而且經常需要進行危險的麻醉程序。非侵入性的基於能量的治療裝置和方法是可用的，但是在效率和有效性方面可能存在各種缺點。Some cosmetic procedures involve invasive procedures that may require invasive surgery. Not only do patients need to endure weeks of recovery time, they often need to undergo dangerous anesthesia procedures. Non-invasive energy-based treatment devices and methods are available, but there may be various disadvantages in terms of efficiency and effectiveness.
在若干實施例中，提供了使用靶向和精確超音成功地實現美學效果的系統和方法，其通過將超音治療波束***到兩個，三個，四個或更多個同時聚焦區域經由熱路徑產生可見且有效的美容效果，用於執行各種治療和/或成像程序。在各種實施例中，超音系統被配置用於聚焦超音以在組織和細胞內產生局部的機械運動，以便產生局部加熱以用於組織凝固或用於非侵入性美學用途的機械細胞膜破裂。在各種實施例中，超音系統被配置用於提拉眉毛（例如，眉毛提拉）。在各種實施例中，超音系統被配置用於提拉升力鬆懈，鬆弛或下垂的組織，例如頦下（下巴下方）和頸部組織。在各種實施例中，超音系統被配置用於改善頸項的線條和皺紋。在各種實施例中，超音系統被配置用於減少脂肪。在各種實施例中，超音系統被配置用於減小脂肪團的外觀。在一些實施例中，提供了一種用於減少脂肪並且隨後治療由脂肪減少引起的鬆弛皮膚的系統。In several embodiments, systems and methods are provided that successfully achieve aesthetic effects using targeted and precise ultrasound by splitting the ultrasound treatment beam into two, three, four, or more simultaneous focal regions via The thermal path produces visible and effective cosmetic effects for performing various treatment and / or imaging procedures. In various embodiments, the ultrasound system is configured to focus ultrasound to produce localized mechanical motion within tissues and cells in order to produce localized heating for tissue coagulation or mechanical cell membrane rupture for non-invasive aesthetic purposes. In various embodiments, the ultrasound system is configured to lift eyebrows (eg, eyebrow lifts). In various embodiments, the ultrasound system is configured to lift loose, slack or sagging tissue, such as the chin (below the chin) and neck tissue. In various embodiments, the ultrasound system is configured to improve the lines and wrinkles of the neck. In various embodiments, the ultrasound system is configured to reduce fat. In various embodiments, the ultrasound system is configured to reduce the appearance of cellulite. In some embodiments, a system for reducing fat and subsequently treating sagging skin caused by fat loss is provided.
儘管本文考慮了用於美容治療的各種實施例，但是在一些實施例中，本文描述的系統和程序也用於非美學應用。Although various embodiments for cosmetic treatment are considered herein, in some embodiments, the systems and procedures described herein are also used for non-aesthetic applications.
在各種實施例中，超音系統被配置用於成像以使組織（例如，組織的真皮和皮下層）可視化以確保換能器與皮膚的適當耦合。在各種實施例中，超音系統被配置用於成像以使組織（例如，組織的真皮和皮下層）可視化以確認適當的治療深度以避免某些組織（例如，骨）。In various embodiments, the ultrasound system is configured for imaging to visualize tissue (eg, dermis and subcutaneous layers of tissue) to ensure proper coupling of the transducer to the skin. In various embodiments, the ultrasound system is configured for imaging to visualize tissue (eg, dermis and subcutaneous layers of tissue) to confirm the appropriate depth of treatment to avoid certain tissues (eg, bone).
在各種實施例中，用多個波束治療組織（例如皮膚組織）提供一個或多個優點，例如，減少治療時間，創建獨特的加熱模式，利用多個通道獲得更大的功率，選擇用相同或不同功率水平在兩個或更多個深度處治療皮膚（例如，淺表肌肉腱膜系統（“SMAS”）中的熱凝固點和皮膚表面處的另一散焦能量，或其他組合），在不同深度處的可選同時治療（例如，同時或在重疊時間段內在1.5mm、3mm和/或4.5mm熱凝固點的皮膚表面下方的深度處）；和/或用一個，兩個或多個同時線性或線聚焦治療，例如在皮膚表面下方的不同深度處或間隔開。在一些實施例中，同時多焦點治療使用抖動。In various embodiments, treating tissue (eg, skin tissue) with multiple beams provides one or more advantages, for example, reducing treatment time, creating unique heating patterns, using multiple channels to obtain greater power, and choosing to use the same or Different power levels treat the skin at two or more depths (for example, the thermal freezing point in the superficial muscle aponeurotic system ("SMAS") and another defocus energy at the skin surface, or other combinations), at different Optional simultaneous treatment at depth (eg, at a depth below the skin surface of 1.5mm, 3mm, and / or 4.5mm thermal coagulation points simultaneously or within overlapping time periods); and / or with one, two or more simultaneous linear Or line focus treatment, for example at different depths or intervals below the skin surface. In some embodiments, simultaneous multi-focus therapy uses jitter.
根據一個實施例，超音治療系統在皮膚表面下方產生兩個或更多個同時治療處理點和/或聚焦區域用於美容治療，其中通過抖動超音波束來擴大治療點。在一個實施例中，聚焦區域是點。在一個實施例中，聚焦區域是線。在一個實施例中，聚焦區域是平面。在一個實施例中，聚焦區域是三維體積或形狀。超音波束焦點的抖動通過改變超音治療波束的頻率並因此改變焦點通過機械地和/或電子地分散焦點的位置通過氣刷使焦點或聚焦區域（例如，焦點、線、平面或體積）像油漆一樣搖動、模糊或濺射來擴大治療區域。在一些實施例中，抖動通過形成更大的治療點和/或聚焦區域來增加功效。在一些實施例中，抖動減輕疼痛，原因是熱點的溫度分佈在組織的更大體積上，允許潛在的劑量減少。在一些實施例中，機械抖動是從超音波束擴展聲能的方法，因此對遠離焦點的組織熱傳導的依賴性較小。在機械抖動的一個實施例中，治療換能器圍繞熱凝固點（TCP）的預期中心局部移動。聲束移動可以是側對側、上下和/或成角度。在機械抖動的一個實施例中，運動機構的移動足夠快以足以在預期TCP周圍產生更平坦的溫度分佈，這允許減小相同受影響組織體積的總聲能或較大受影響組織體積的相同總聲能或其任何組合。According to one embodiment, the ultrasound treatment system generates two or more simultaneous treatment treatment points and / or focus areas below the skin surface for cosmetic treatment, wherein the treatment points are expanded by shaking the ultrasound beam. In one embodiment, the focus area is a point. In one embodiment, the focus area is a line. In one embodiment, the focus area is flat. In one embodiment, the focus area is a three-dimensional volume or shape. The jitter of the focus of the ultrasound beam changes the frequency of the ultrasound therapy beam and thus changes the focus by mechanically and / or electronically dispersing the position of the focus. The paint shakes, blurs or spatters to expand the treatment area. In some embodiments, dithering increases efficacy by forming larger treatment points and / or focus areas. In some embodiments, shaking reduces pain because the temperature of the hot spot is distributed over a larger volume of tissue, allowing a potential dose reduction. In some embodiments, mechanical shaking is a method of expanding acoustic energy from a supersonic beam, and therefore has less dependence on thermal conduction of tissue away from the focal point. In one embodiment of mechanical shaking, the therapeutic transducer moves locally around the expected center of the thermal freezing point (TCP). The beam movement can be side to side, up and down, and / or angled. In one embodiment of mechanical shaking, the movement of the kinematic mechanism is fast enough to produce a flatter temperature distribution around the expected TCP, which allows reducing the total acoustic energy of the same affected tissue volume or the same of the larger affected tissue volume Total acoustic energy or any combination thereof.
根據各種實施例，頻率調製修改聚焦區域的位置和/或聚焦區域之間的間隔，使得經由頻率調製電子抖動波束精確地改變和/或移動波束焦點的位置。例如，在一個實施例中，1.5mm的間隔可以使用小頻率擺動以+/-0.1mm進行抖動。在各種實施例中，0.5、0.75、1.0、1.2、1.5、2.0mm中的任何一個或多個間隔可以使用頻率擺動以+/- 0.01、0.05、0.1、0.12、0.15、0.20、0.25、0.30mm進行抖動。在各種實施例中，頻率被調製1-200％（例如，1％、5％、10％、15％、20％、25％、30％、35％、40％、45％、50％、100％、120％、150％、180％、200％及其中的任何範圍）。According to various embodiments, frequency modulation modifies the position of the focus area and / or the spacing between the focus areas so that the electronic dither beam via frequency modulation accurately changes and / or moves the position of the beam focus. For example, in one embodiment, the 1.5 mm interval can be dithered at +/- 0.1 mm using small frequency swings. In various embodiments, any one or more intervals of 0.5, 0.75, 1.0, 1.2, 1.5, 2.0 mm can use frequency swing to +/- 0.01, 0.05, 0.1, 0.12, 0.15, 0.20, 0.25, 0.30 mm Perform dithering. In various embodiments, the frequency is modulated 1-200% (eg, 1%, 5%, 10%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, 50%, 100 %, 120%, 150%, 180%, 200% and any range).
若干實施例涉及用於提供一個或多個（例如，多個或許多）聚焦區域和/或超音治療點以快速、安全、高效和有效地執行各種超音治療和/或成像程序的裝置、系統和方法。在一些實施例中，不使用成像。一些實施例涉及將超音治療波束從單個超音換能器和/或單個超音換能元件***到兩個、三個、四個或更多個聚焦區域。在一些實施例中，用頻率調製電子地操縱多個超音波束。在一些實施例中，使用頻率調製的多個和/或***的超音波束孔徑的抖動（例如，電子抖動）在多個位置中提供治療區域或點。在一些實施例中，抖動涉及能量波束的焦點的位置/定位的有意移動。例如，在一個實施例中，抖動涉及搖動、移動、振動、改變單個聚焦區域的定位和/或位置，和/或兩個或更多個聚焦區域之間的相對間隔。在各種實施例中，聚焦區域的相對位置抖動1-50％（例如，1％、5％、10％、15％、20％、25％、30％、35％、40％、45％、50％及其中的任何範圍，例如某個百分比的平均位置的百分比）。在各種實施例中，聚焦區域之間的間隔抖動範圍在1-50％之間（例如，1％、5％、10％、15％、20％、25％、30％、35％、40％、45％、50％及其中的任何範圍）。在一些實施例中，取決於系統設計，可以通過機械、電子或機械和電子手段的組合來實現抖動。在機械抖動的一個實施例中，超音波束通過治療換能器或患者或其任何組合的機械平移或傾斜而圍繞預期TCP中心局部移動。機械平移和/或傾斜能夠實現聲能的擴展，使得克服組織的熱傳導限制。與固定超音治療裝置相比，這在組織中產生更平坦的溫度分佈以減小總聲能以產生相同的受影響組織體積或具有相同的總聲能以增加受影響組織體積。在電子抖動的各種實施例中，頻率、相位、幅度調製或基於時間的技術用於與唯一限定的換能器組合以在沒有任何機械移動的情況下在組織中移動超音波束。在一個實施例中，超音波束的電子移動明顯快於機械移動以克服組織的熱導率限制。在各種實施例中，經由抖動的相對聚焦區域定位的比率為1:1000、1:500、1:200、1:100、1:50、1:25、1:10、1:2或1:1000至1:1之間的任何比率。在各種實施例中，經由抖動的相對聚焦區域定位之間的間隔的比率為1:1000、1:500、1:200、1:100、1:50、1:25、1:10、1:2或1:1000至1:1之間的任何比率。例如，在一些實施例中，聚焦區域在“1”處被激活，並且未治療組織的開放間隔比率在該比率的第二數字中被提供。例如，在一個實施例中，抖動間隔例如為1mm，抖動距離為0.1mm，因此比率為1:10。在各種實施例中，經由抖動的聚焦區域之間的間隔的比率為1:1000、1:500、1:200、1:100、1:50、1:25、1:10、1:2或1:1000至1:1之間的任何比率。在一些實施例中，抖動同時聚焦區域的間隔。在一些實施例中，治療點和/或區域在組織中同時形成。在各種實施例中，用於執行各種治療和/或成像程序的抖動是調製的和/或多相的，具有受控的頻率變化。一些實施例涉及將超音治療波束***到兩個、三個、四個或更多個聚焦區域，用於例如用抖動、極化、定相和/或調製技術和/或成像程序執行各種治療。Several embodiments relate to devices for providing one or more (eg, multiple or many) focus areas and / or ultrasound treatment points to perform various ultrasound treatment and / or imaging procedures quickly, safely, efficiently, and effectively, Systems and methods. In some embodiments, imaging is not used. Some embodiments involve splitting the ultrasound therapy beam from a single ultrasound transducer and / or a single ultrasound transducer element into two, three, four, or more focal regions. In some embodiments, multiple ultrasound beams are electronically manipulated with frequency modulation. In some embodiments, dithering (eg, electronic dithering) using frequency-modulated multiple and / or split supersonic beam apertures provides treatment areas or points in multiple locations. In some embodiments, jitter involves intentional movement of the position / location of the focus of the energy beam. For example, in one embodiment, shaking involves shaking, moving, vibrating, changing the positioning and / or position of a single focus area, and / or the relative spacing between two or more focus areas. In various embodiments, the relative position of the focus area shakes by 1-50% (eg, 1%, 5%, 10%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, 50 % And any range in it, such as a certain percentage of the average position). In various embodiments, the interval jitter between focus areas is between 1-50% (eg, 1%, 5%, 10%, 15%, 20%, 25%, 30%, 35%, 40% , 45%, 50% and any range). In some embodiments, depending on the system design, dithering may be achieved by mechanical, electronic, or a combination of mechanical and electronic means. In one embodiment of mechanical shaking, the ultrasound beam is moved locally around the expected TCP center by mechanical translation or tilt of the treatment transducer or patient or any combination thereof. Mechanical translation and / or tilting can enable the expansion of acoustic energy, so that the thermal conduction limitation of the tissue is overcome. Compared to fixed ultrasound treatment devices, this produces a flatter temperature distribution in the tissue to reduce the total acoustic energy to produce the same volume of affected tissue or to have the same total acoustic energy to increase the volume of affected tissue. In various embodiments of electronic dithering, frequency, phase, amplitude modulation, or time-based techniques are used in combination with uniquely defined transducers to move the ultrasound beam in the tissue without any mechanical movement. In one embodiment, the electronic movement of the ultrasound beam is significantly faster than the mechanical movement to overcome the thermal conductivity limitation of the tissue. In various embodiments, the ratio of relative focus area positioning via dithering is 1: 1000, 1: 500, 1: 200, 1: 100, 1:50, 1:25, 1:10, 1: 2, or 1: Any ratio between 1000 and 1: 1. In various embodiments, the ratios of the intervals between relative focus area positioning via dithering are 1: 1000, 1: 500, 1: 200, 1: 100, 1:50, 1:25, 1:10, 1: 2 or any ratio between 1: 1000 and 1: 1. For example, in some embodiments, the focus area is activated at "1" and the open interval ratio of untreated tissue is provided in the second number of the ratio. For example, in one embodiment, the shaking interval is, for example, 1 mm, and the shaking distance is 0.1 mm, so the ratio is 1:10. In various embodiments, the ratio of the intervals between the focus areas via dithering is 1: 1000, 1: 500, 1: 200, 1: 100, 1:50, 1:25, 1:10, 1: 2 or Any ratio between 1: 1000 and 1: 1. In some embodiments, the dithering simultaneously focuses the spacing of the regions. In some embodiments, treatment points and / or regions are formed simultaneously in the tissue. In various embodiments, the jitter used to perform various treatment and / or imaging procedures is modulated and / or multi-phase, with controlled frequency changes. Some embodiments involve splitting the ultrasound therapy beam into two, three, four or more focal areas, for example for performing various treatments with dithering, polarization, phasing and / or modulation techniques and / or imaging procedures .
在本文公開的若干實施例中，非侵入性超音系統適於用於實現以下有益的美學和/或美容改善效果中的一個或多個：面部提拉、眉毛提拉、下巴提拉、眼部治療（例如，顴骨袋、治療眶下鬆弛）、皺紋減少、脂肪減少（例如，脂肪和/或脂肪團的治療）、脂肪團（其可稱為女性脂肪營養不良）治療（例如，凹陷或非凹陷型女性脂肪營養不良）、肩部改善（例如，上胸）、臀部提拉（例如，臀部收緊）、皮膚收緊（例如，治療鬆弛以導致面部或身體收緊，例如面部、頸部、胸部、手臂、大腿、腹部、臀部等）、疤痕減少（例如，減少***囊纖維化）、燒傷治療、紋身去除、靜脈去除、靜脈減少、治療汗腺、治療多汗症、曬斑去除、痤瘡治療、丘疹減少。本發明的若干實施例是特別有利的，原因是它們包括一個、幾個或所有以下益處：（i）更快的治療時間、（ii）治療期間的更少疼痛、（iii）治療後的更少疼痛、（iv）更短的恢復時間、（v）更高效的治療、（vi）更高的顧客滿意度、（vii）完成治療所需的能量更少和/或（viii）由抖動的聚焦區域提供更大的治療區域。配置成在各種深度處產生多個TCP的同時多深度治療裝置的實施例的各種優點包括在多個深度處產生同時TCP。在一個實施例中，優點是消除了多個換能器，由此減少了操作者的換能器交換。在一個實施例中，優點是更快的治療時間。在一個實施例中，優點是更少的按鈕按壓遞送相同數量的線。在一個實施例中，優點是同時遞送的TCP之間的距離的調製。在一個實施例中，優點是在沿著機械運動線的每個深度處保持TCP的節距分離。在一個實施例中，優點是避免在多個深度處的脈衝堆疊。在一個實施例中，優點是能夠產生更大的凝固和細胞凋亡區域。在一個實施例中，優點是能夠沿著三個維度遞送微凝固線。在一個實施例中，使用電致伸縮器的優點包括用一個換能器放置在患者的身體上產生兩個以上線。在一個實施例中，使用電致伸縮器的優點是調製同時遞送的TCP之間的距離。在一個實施例中，優點是調製從同時治療調製模式減弱空間高頻諧波的能力。在一個實施例中，使用電致伸縮器的優點提供了向調製模式添加零點的可能性。在一個實施例中，使用電致伸縮器的優點是有效地調製同時遞送的TCP之間的距離，同時對相對表面進行電子轉向和聚焦控制。這可以是正交於（或相對於彼此成任何角，例如0º至180º（5º、10º、15º、20º、30º、45º、60º、90º或以上））電致伸縮器條帶的條帶、環形圈和段的形式。在各種實施例中，換能器是分段的。在各種實施例中，扁平換能器可以用透鏡聚焦。在各種實施例中，換能器球形地聚焦到一個或多個點。在各種實施例中，換能器圓柱形地聚焦到一個或多個線。In several embodiments disclosed herein, the non-invasive ultrasound system is suitable for achieving one or more of the following beneficial aesthetic and / or cosmetic improvement effects: facial lift, eyebrow lift, chin lift, eye Partial treatment (eg, zygomatic pouch, treatment of suborbital sagging), wrinkle reduction, fat loss (eg, treatment of fat and / or cellulite), cellulite (which may be referred to as female lipodystrophy) treatment (eg, depression Or non-recessed women with fatty malnutrition), shoulder improvement (eg, upper chest), buttock lift (eg, hip tightening), skin tightening (eg, treating relaxation to cause tightening of the face or body, such as the face, Neck, chest, arms, thighs, abdomen, buttocks, etc.), scar reduction (eg, reduction of breast cyst fibrosis), burn treatment, tattoo removal, vein removal, vein reduction, treatment of sweat glands, treatment of hyperhidrosis, sunburn removal , Acne treatment, and reduced pimples. Several embodiments of the present invention are particularly advantageous because they include one, several, or all of the following benefits: (i) faster treatment time, (ii) less pain during treatment, (iii) more after treatment Less pain, (iv) shorter recovery time, (v) more efficient treatment, (vi) higher customer satisfaction, (vii) less energy required to complete the treatment and / or (viii) by jitter The focus area provides a larger treatment area. Various advantages of embodiments of a simultaneous multi-depth treatment device configured to generate multiple TCPs at various depths include generating simultaneous TCPs at multiple depths. In one embodiment, the advantage is that multiple transducers are eliminated, thereby reducing the operator's transducer exchange. In one embodiment, the advantage is faster treatment time. In one embodiment, the advantage is that fewer button presses deliver the same number of lines. In one embodiment, the advantage is the modulation of the distance between TCPs delivered simultaneously. In one embodiment, the advantage is that the pitch of the TCP is kept separated at each depth along the mechanical motion line. In one embodiment, the advantage is to avoid pulse stacking at multiple depths. In one embodiment, the advantage is the ability to produce larger areas of coagulation and apoptosis. In one embodiment, the advantage is the ability to deliver microcoagulation lines along three dimensions. In one embodiment, the advantages of using an electrostrictor include placing more than two wires with one transducer placed on the patient's body. In one embodiment, the advantage of using an electrostrictor is to modulate the distance between TCPs delivered simultaneously. In one embodiment, the advantage is the ability of modulation to attenuate spatial high frequency harmonics from the simultaneous treatment modulation mode. In one embodiment, the advantages of using electrostrictors provide the possibility of adding zeros to the modulation pattern. In one embodiment, the advantage of using an electrostrictor is to effectively modulate the distance between TCPs that are delivered simultaneously, while performing electronic steering and focus control on the opposing surfaces. This can be a strip or loop that is orthogonal (or at any angle relative to each other, such as 0º to 180º (5º, 10º, 15º, 20º, 30º, 45º, 60º, 90º or more)) The form of circles and segments. In various embodiments, the transducer is segmented. In various embodiments, the flat transducer can be focused with a lens. In various embodiments, the transducer is spherically focused to one or more points. In various embodiments, the transducer is cylindrically focused to one or more wires.
根據各種實施例，美容超音治療系統和/或方法可以非侵入性地產生單個或多個抖動美容治療區域和/或熱凝固點，其中超音聚焦在皮膚表面下的組織中的治療區域中的一個或多個位置，並經由頻率的變化（例如，經由頻率調製）移動。一些系統和方法在組織中的不同位置處，例如在不同的深度、高度、寬度和/或位置處提供美容治療。在一個實施例中，一種方法和系統包括多深度/高度/寬度換能器系統，其被配置用於向一個或多個感興趣區域，例如在感興趣治療區域的至少一個深度、感興趣表面區域和/或感興趣皮下區域之間，提供超音治療。在一個實施例中，一種方法和系統包括換能器系統，其被配置用於向一個以上感興趣區域，例如在組織中的感興趣區域中的各種位置中的至少兩個點之間（例如，在一個或多個固定或可變深度、高度、寬度和/或取向等處），提供超音治療。一些實施例可以***波束以聚焦在兩個、三個、四個或更多個焦點（例如，多個焦點、多焦點）處以用於美容治療區域和/或用於在組織中的感興趣區域中成像。焦點的位置和/或抖動可以在組織內軸向地、橫向地或以其他方式定位。一些實施例可以被配置用於空間控制，例如通過焦點的位置和/或抖動，改變從換能器到反射表面的距離，和/或改變聚焦或未聚焦到感興趣區域的能量的角，和/或配置用於時間控制，例如通過控制換能器的頻率、驅動幅度和定時的變化。在一些實施例中，用極化、相位極化、雙相極化和/或多相極化實現多個治療區域或焦點的位置和/或抖動。在一些實施例中，用定相，例如在一個實施例中電定相，實現多個治療區域或焦點的位置。結果，可以隨時間動態地控制治療區域的位置的變化，感興趣區域中的治療區域或病變的數量、形狀、大小和/或體積以及熱狀況。According to various embodiments, a cosmetic ultrasound treatment system and / or method may non-invasively generate a single or multiple shaking cosmetic treatment areas and / or thermal freezing points, wherein the ultrasound is focused on the treatment area in the tissue under the skin surface One or more positions, and move via changes in frequency (eg, via frequency modulation). Some systems and methods provide cosmetic treatments at different locations in the tissue, such as at different depths, heights, widths, and / or locations. In one embodiment, a method and system includes a multi-depth / height / width transducer system configured to one or more regions of interest, for example at least one depth, surface of interest at a treatment area of interest Between areas and / or subcutaneous areas of interest, ultrasound therapy is provided. In one embodiment, a method and system includes a transducer system configured to direct more than one region of interest, for example, between at least two points in various locations in a region of interest in a tissue (eg , At one or more fixed or variable depths, heights, widths and / or orientations, etc., to provide ultrasound treatment. Some embodiments may split the beam to focus at two, three, four, or more focal points (eg, multiple focal points, multiple focal points) for the cosmetic treatment area and / or for the area of interest in the tissue Medium imaging. The location and / or jitter of the focal point can be positioned axially, laterally, or otherwise within the tissue. Some embodiments may be configured for spatial control, such as changing the distance from the transducer to the reflective surface through the position and / or jitter of the focal point, and / or changing the angle of energy focused or unfocused to the region of interest, and / Or configured for time control, for example by controlling the frequency, drive amplitude and timing changes of the transducer. In some embodiments, the position and / or jitter of multiple treatment areas or focal points is achieved with polarization, phase polarization, bi-phase polarization, and / or multi-phase polarization. In some embodiments, phasing, such as electrical phasing in one embodiment, is used to achieve the location of multiple treatment areas or focal points. As a result, the change in the position of the treatment area, the number, shape, size, and / or volume of the treatment area or lesion in the area of interest and the thermal conditions can be dynamically controlled over time.
根據各種實施例，美容超音治療系統和/或方法可以使用頻率調製、相位調製、極化、非線性聲學和/或傅立葉變換中的一個或多個來產生多個美容治療區域以用一個或多個超音部分創建任何空間週期模式。在一個實施例中，系統使用陶瓷水平的極化同時或依序地遞送單個或多個治療區域。在一個實施例中，極化模式取決於焦深和頻率，以及奇數或偶數函數的使用。在一個實施例中，應用極化模式，其可以是奇數或偶數函數的組合，並且基於焦深和/或頻率。在一個實施例中，可以在兩個或更多個維度中使用過程以創建任何空間週期模式。在一個實施例中，通過使用非線性聲學和傅立葉變換軸向和橫向***超音波束以顯著減少治療時間。在一個實施例中，來自系統的調製和來自陶瓷或換能器的幅度調製可以用於在組織中依序地或同時地放置多個治療區域。According to various embodiments, the cosmetic ultrasound treatment system and / or method may use one or more of frequency modulation, phase modulation, polarization, nonlinear acoustics, and / or Fourier transform to generate multiple cosmetic treatment areas to Multiple supersonic sections create any spatial cycle pattern. In one embodiment, the system uses ceramic-level polarization to deliver single or multiple treatment areas simultaneously or sequentially. In one embodiment, the polarization mode depends on the depth of focus and frequency, and the use of odd or even functions. In one embodiment, a polarization mode is applied, which may be a combination of odd or even functions, and is based on depth of focus and / or frequency. In one embodiment, the process can be used in two or more dimensions to create any spatial periodic pattern. In one embodiment, the treatment time is significantly reduced by using non-linear acoustics and Fourier transform to split the ultrasonic beams axially and laterally. In one embodiment, the modulation from the system and the amplitude modulation from the ceramic or transducer can be used to place multiple treatment areas sequentially or simultaneously in the tissue.
在一個實施例中，美學成像和治療系統包括超音探頭，所述超音探頭包括超音換能器，所述超音換能器配置成通過頻率調製通過多個能量波束孔徑的電子抖動在焦深處的多個位置處對組織施加超音治療。在一個實施例中，系統包括耦合到超音探頭的控制模組，用於控制超音換能器。In one embodiment, the aesthetic imaging and treatment system includes a supersonic probe that includes a supersonic transducer configured to electronically dither through multiple energy beam apertures by frequency modulation Ultrasound treatment is applied to the tissue at multiple locations in the depth of focus. In one embodiment, the system includes a control module coupled to the ultrasound probe for controlling the ultrasound transducer.
在一個實施例中，系統包括抖動，所述抖動配置成提供多個單獨的美容治療區域之間的可變間隔。在一個實施例中，單獨的美容治療區域的序列具有在約0.01mm至約25mm的範圍內（例如，1mm、1.5mm、2mm、2.5mm、3mm、5mm、10mm、20mm及其中的任何數值範圍）的治療間隔，間隔的抖動改變為1-50％（例如，1％、5％、10％、15％、20％、25％、30％、35％、40％、45％、50％及其中的任何範圍）。在一個實施例中，單獨的美容治療區域的序列具有在約0.01mm至約100mm的範圍內（例如，1mm、1.5mm、2mm、2.5mm、3mm、5mm、10 mm、20 mm、25 mm、30 mm、35 mm、40 mm、45 mm、50 mm、60 mm、70 mm、80 mm、90 mm和100 mm，以及其中的任何數值範圍）的治療間隔，間隔的抖動改變為1-50％（例如，1％、5％、10％、15％、20％、25％、30％、35％、40％、45％、50％及其中的任何範圍）。In one embodiment, the system includes a dither configured to provide a variable interval between multiple individual cosmetic treatment areas. In one embodiment, the sequence of individual cosmetic treatment areas has a range of about 0.01 mm to about 25 mm (eg, 1 mm, 1.5 mm, 2 mm, 2.5 mm, 3 mm, 5 mm, 10 mm, 20 mm, and any numerical range thereof ) Treatment interval, the interval jitter changes from 1-50% (eg, 1%, 5%, 10%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, 50% and Any of them). In one embodiment, the sequence of individual cosmetic treatment areas has a range of about 0.01 mm to about 100 mm (eg, 1 mm, 1.5 mm, 2 mm, 2.5 mm, 3 mm, 5 mm, 10 mm, 20 mm, 25 mm, 30 mm, 35 mm, 40 mm, 45 mm, 50 mm, 60 mm, 70 mm, 80 mm, 90 mm, and 100 mm, and any value range), the interval jitter changes to 1-50% (For example, 1%, 5%, 10%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, 50% and any range thereof).
在一個實施例中，系統還包括移動機構，所述移動機構配置成被編程以提供多個單獨的美容治療區域之間的恆定或可變的間隔。在一個實施例中，單獨的美容治療區域的序列具有在約0.01mm至約50mm的範圍內（例如，0.1、0.5、1、2、3、4、5、6、7、8、9、10、15、19、20、25、30、35、40、45、49mm或其中的任何範圍或值）的治療間隔。在一個實施例中，單獨的美容治療區域的序列具有在約0.01mm至約100mm的範圍內（例如，0.1、0.5、1、2、3、4、5、6、7、8、9、10、15、20、25、30、35、40、50、100mm或其中的任何範圍或值）的治療間隔。在一個實施例中，沿著約25mm的距離提供治療區域。在一個實施例中，沿著約50mm的距離提供治療區域。在各種實施例中，沿著5mm至100mm（例如，10mm、20mm、25mm、35mm、50mm、75mm、100mm及其中的任何量或範圍）的距離提供治療區域。在各種實施例中，沿著線性和/或彎曲距離提供治療區域。In one embodiment, the system also includes a movement mechanism configured to be programmed to provide a constant or variable interval between multiple individual cosmetic treatment areas. In one embodiment, the sequence of individual cosmetic treatment areas has a range of about 0.01 mm to about 50 mm (eg, 0.1, 0.5, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 , 15, 19, 20, 25, 30, 35, 40, 45, 49mm or any range or value) treatment interval. In one embodiment, the sequence of individual cosmetic treatment areas has a range of about 0.01 mm to about 100 mm (eg, 0.1, 0.5, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 , 15, 20, 25, 30, 35, 40, 50, 100 mm or any range or value) treatment interval. In one embodiment, the treatment area is provided along a distance of about 25 mm. In one embodiment, the treatment area is provided along a distance of about 50 mm. In various embodiments, the treatment area is provided along a distance of 5 mm to 100 mm (eg, 10 mm, 20 mm, 25 mm, 35 mm, 50 mm, 75 mm, 100 mm, and any amount or range thereof). In various embodiments, the treatment area is provided along linear and / or curved distances.
例如，在一些非限制性實施例中，換能器可以被配置用於0.5mm、1.0mm、1.5mm、2mm、3mm、4.5mm、6mm、小於3mm、0.5mm至5mm之間、1.5mm至4.5mm之間、超過4.5mm、超過6mm以及0.1mm-3mm範圍內、0.1mm-4.5mm範圍內、0.1mm-25mm範圍內、0.1mm-100mm範圍內的組織深度，以及其中的任何深度（例如，6mm、10mm、13mm、15mm、17mm）。在若干實施例中，在皮膚表面下方的深度處治療組織，並且不損害皮膚表面。相反，在皮膚表面下方的深度處實現的治療效果導致皮膚表面的有利的美容外觀。在其他實施例中，皮膚表面用超音治療（例如，在小於0.5mm的深度處）。For example, in some non-limiting embodiments, the transducer may be configured for 0.5mm, 1.0mm, 1.5mm, 2mm, 3mm, 4.5mm, 6mm, less than 3mm, between 0.5mm to 5mm, 1.5mm to Tissue depth between 4.5mm, more than 4.5mm, more than 6mm and 0.1mm-3mm, 0.1mm-4.5mm, 0.1mm-25mm, 0.1mm-100mm, and any depth ( For example, 6mm, 10mm, 13mm, 15mm, 17mm). In several embodiments, the tissue is treated at a depth below the skin surface and does not damage the skin surface. In contrast, the therapeutic effect achieved at a depth below the skin surface results in a favorable cosmetic appearance of the skin surface. In other embodiments, the skin surface is treated with ultrasound (eg, at a depth of less than 0.5 mm).
運動機構的一個好處是它可以提供超音換能器的更高效、準確和精確的使用，用於成像和/或治療目的。該類型的運動機構相對於固定在殼體中的空間中的多個換能器的傳統固定陣列的一個優點是固定陣列是分開固定距離的。在一個實施例中，換能器模組配置成提供在約1W至約100W或者100W至1000W（例如，3-30W、7-30W、21W-33W、200W、500W、750W、900W）或更高的範圍內的超音治療的聲功率和約1MHz至約20MHz的頻率以通過熱加熱組織以引起凝固。在一個實施例中，換能器模組配置成提供對於峰值或平均能量在約1W至約500W（例如，3-30W、7-30W、21-33W、100W、220W或以上）的範圍內的超音治療的聲功率和約1MHz至約20MHz的頻率以通過熱加熱組織以引起凝固。在一些實施例中，遞送瞬時能量。在一些實施例中，遞送平均能量。在一個實施例中，聲功率可以在約1MHz至約20MHz（例如，1MHz、3MHz、4MHz、4.5MHz、7MHz、10MHz、2-12MHz、15MHz、18MHz、2-18MHz）的頻率範圍內在1W至約100W的範圍，或在約3MHz至約8MHz（例如，3MHz、4MHz、4.5MHz、7MHz）的頻率範圍內在約10W至約50WMHz的範圍。在一個實施例中，聲功率可以在約1MHz至約12MHz（例如，1MHz、4MHz、7MHz、10MHz、2-12MHz）的頻率範圍內在1W至約500W的範圍，或者在約3MHz至約8MHz或3MHz至10MHz的頻率範圍內在約10W至約220W的範圍。在一個實施例中，聲功率和頻率在約4.3MHz處約為40W並且在約7.5MHz處約為30W。由該聲功率產生的聲能可以在約0.01焦耳（“J”）至約10J或約2J至約5J之間。由該聲功率產生的聲能可以在約0.01J至約60,000J之間（例如，經由軀體加熱，用於塑身、頦下脂肪、腹部和/或側腹、手臂、大腿內側、大腿外側、臀部、腹部鬆弛、脂肪團），約10 J或約2 J至約5 J。在一些實施例中，聲能在小於約3J的範圍內。在各種實施例中，治療功率為1kW/cm2 至100kW/cm2 、15kW/cm2 至75kW/cm2 、1kW/cm2 至5kW/cm2 、500W/cm2 至10kW/cm2 、3kW/cm2 至10kW/cm2 、15kW/cm2 至50kW/cm2 、20kW/cm2 至40kW/cm2 和/或15kW/cm2 至35kW/cm2 。One benefit of the motion mechanism is that it can provide more efficient, accurate, and precise use of ultrasound transducers for imaging and / or therapeutic purposes. One advantage of this type of motion mechanism over conventional fixed arrays of multiple transducers fixed in the space in the housing is that the fixed arrays are separated by a fixed distance. In one embodiment, the transducer module is configured to provide between about 1W to about 100W or 100W to 1000W (eg, 3-30W, 7-30W, 21W-33W, 200W, 500W, 750W, 900W) or higher The ultrasonic power of the ultrasonic treatment within the range and the frequency of about 1MHz to about 20MHz to heat the tissue by heat to cause coagulation. In one embodiment, the transducer module is configured to provide a peak or average energy in the range of about 1W to about 500W (eg, 3-30W, 7-30W, 21-33W, 100W, 220W or more) The sound power of ultrasound treatment and the frequency of about 1 MHz to about 20 MHz to heat the tissue by heat to cause coagulation. In some embodiments, instantaneous energy is delivered. In some embodiments, the average energy is delivered. In one embodiment, the acoustic power may range from 1 W to about 1 MHz to about 20 MHz (eg, 1 MHz, 3 MHz, 4 MHz, 4.5 MHz, 7 MHz, 10 MHz, 2-12 MHz, 15 MHz, 18 MHz, 2-18 MHz) in the frequency range 100W, or in the frequency range of about 3MHz to about 8MHz (eg, 3MHz, 4MHz, 4.5MHz, 7MHz) in the range of about 10W to about 50WMHz. In one embodiment, the acoustic power may be in the range of 1W to about 500W in the frequency range of about 1MHz to about 12MHz (eg, 1MHz, 4MHz, 7MHz, 10MHz, 2-12MHz), or about 3MHz to about 8MHz or 3MHz The frequency range to 10 MHz is in the range of about 10 W to about 220 W. In one embodiment, the acoustic power and frequency are about 40W at about 4.3MHz and about 30W at about 7.5MHz. The acoustic energy produced by this acoustic power may be between about 0.01 Joule ("J") to about 10J or about 2J to about 5J. The sound energy produced by this sound power can be between about 0.01J and about 60,000J (eg, heated by the body for body shaping, submental fat, abdomen and / or flanks, arms, inner thighs, outer thighs, buttocks , Abdominal relaxation, cellulite), about 10 J or about 2 J to about 5 J. In some embodiments, the acoustic energy is in the range of less than about 3J. In various embodiments, the therapeutic power of 1kW / cm 2 to 100kW / cm 2, 15kW / cm 2 to 75kW / cm 2, 1kW / cm 2 to 5kW / cm 2, 500W / cm 2 to 10kW / cm 2, 3kW / cm 2 to 10 kW / cm 2 , 15 kW / cm 2 to 50 kW / cm 2 , 20 kW / cm 2 to 40 kW / cm 2 and / or 15 kW / cm 2 to 35 kW / cm 2 .
在各種實施例中，一種用於抖動來自超音換能器的多個同時焦點的超音治療系統包括超音探頭和耦合到超音探頭的控制模組，用於控制超音換能器。超音探頭包括具有單個換能元件的超音換能器，所述單個換能元件適於在焦深處的多個間隔位置處同時對組織施加超音治療。超音換能器至少用第一極化配置和第二極化配置進行極化。控制模組經由第一聚焦區域和第二聚焦區域的抖動來修改間隔位置之間的間隔，使得經由頻率調製的抖動在間隔位置處精確地移動波束焦點的位置。In various embodiments, a supersonic therapy system for shaking multiple simultaneous focal points from a supersonic transducer includes a supersonic probe and a control module coupled to the supersonic probe for controlling the supersonic transducer. The ultrasound probe includes a ultrasound transducer with a single transducer element adapted to simultaneously apply ultrasound therapy to tissue at multiple spaced locations at the depth of focus. The ultrasonic transducer is polarized with at least a first polarization configuration and a second polarization configuration. The control module modifies the interval between the interval positions via the jitter of the first focus area and the second focus area so that the jitter via frequency modulation accurately moves the position of the beam focus at the interval position.
在一個實施例中，多個位置以以線性序列定位在美容治療區域內，其中間隔位置以經由頻率擺動抖動的間隔分離。在一個實施例中，第一組位置定位在第一美容治療區域內，並且第二組位置定位在第二美容治療區域內，第一區域不同於第二區域。在一個實施例中，超音換能器適於使用幅度調製施加超音治療，由此超音換能器的多個部分適於以多個聲強度幅度發射超音治療，其中第一幅度不同於第二幅度。在一個實施例中，超音換能器的至少一部分適於以兩個或更多個聲強度幅度發射超音治療，並且其中由壓電器的至少一部分發射的超音治療的幅度隨時間變化。在一個實施例中，超音換能器包括壓電材料，並且超音換能器的多個部分適於響應於施加到超音換能器的電場而產生多個相應的壓電材料變化。在一個實施例中，多個壓電材料變化包括壓電材料的膨脹和壓電材料的收縮中的至少一種。在一個實施例中，超音換能器適於經由相移施加超音治療，由此超音換能器的多個部分適於以多個聲強度相位發射超音治療，其中第一相位不同於第二相位。在一個實施例中，多個相位包括離散相位值。在一個實施例中，超音換能器適於使用幅度調製施加超音治療，由此超音換能器的多個部分適於以多個聲強度幅度發射超音治療，其中第一幅度不同於第二幅度，並且施加超音治療，由此超音換能器的多個部分適於以多個聲強度相位發射超音治療，其中第一相位不同於第二相位。在一些實施例中通過減少皮膚鬆弛實現皮膚收緊以治療體重減輕後皮膚過多或鬆弛的受試者，無論這種體重減輕是自然發生還是通過外科手術進行的。In one embodiment, a plurality of positions are positioned within the cosmetic treatment area in a linear sequence, wherein the spaced positions are separated at intervals shaking by frequency wobbling. In one embodiment, the first set of locations is located within the first cosmetic treatment area, and the second set of locations is located within the second cosmetic treatment area, the first area is different from the second area. In one embodiment, the ultrasound transducer is adapted to apply ultrasound therapy using amplitude modulation, whereby portions of the ultrasound transducer are adapted to emit ultrasound therapy at multiple sound intensity amplitudes, where the first amplitude is different In the second range. In one embodiment, at least a portion of the ultrasound transducer is adapted to emit ultrasound therapy at two or more amplitudes of sound intensity, and wherein the amplitude of the ultrasound therapy emitted by at least a portion of the piezoelectric device changes over time. In one embodiment, the ultrasonic transducer includes piezoelectric material, and portions of the ultrasonic transducer are adapted to produce a plurality of corresponding piezoelectric material changes in response to an electric field applied to the ultrasonic transducer. In one embodiment, the plurality of piezoelectric material changes includes at least one of expansion of the piezoelectric material and contraction of the piezoelectric material. In one embodiment, the ultrasound transducer is adapted to apply ultrasound therapy via phase shift, whereby portions of the ultrasound transducer are adapted to emit ultrasound therapy in multiple sound intensity phases, where the first phase is different In the second phase. In one embodiment, the multiple phases include discrete phase values. In one embodiment, the ultrasound transducer is adapted to apply ultrasound therapy using amplitude modulation, whereby portions of the ultrasound transducer are adapted to emit ultrasound therapy at multiple sound intensity amplitudes, where the first amplitude is different At a second amplitude, and ultrasound therapy is applied, whereby portions of the ultrasound transducer are adapted to emit ultrasound therapy in multiple sound intensity phases, where the first phase is different from the second phase. In some embodiments, skin tightening is achieved by reducing skin relaxation to treat subjects with excessive or loose skin after weight loss, whether such weight loss occurs naturally or through surgery.
在各種實施例中，一種在美容治療中用於抖動來自超音換能器的多個同時焦點的超音治療系統包括超音探頭，所述超音探頭包括適於經由抖動修改第一聚焦區域和第二聚焦區域之間的間隔的控制模組，可操作地控制用於提供超音治療的超音治療功能的開關，以及適於在單獨的熱美容治療區域的至少一對同時序列中引導超音治療的移動機構，以及適於施加超音治療的換能器模組。換能器模組適用於超音成像和超音治療。換能器模組適於耦合到超音探頭。換能器模組包括超音換能器，其適於在焦深處的多個位置處對組織施加超音治療。換能器模組適於可操作地耦合到開關和移動機構中的至少一個。控制模組包括處理器和顯示器，用於控制換能器模組。In various embodiments, a supersonic therapy system for dithering multiple simultaneous focal points from a supersonic transducer in cosmetic treatment includes a supersonic probe including a first focus area adapted to modify via dithering A control module for the interval between the second focus area and the switch for operably controlling the ultrasound treatment function for providing ultrasound treatment, and suitable for guiding in at least one pair of simultaneous sequences of separate thermal cosmetic treatment areas A mobile mechanism for ultrasound therapy, and a transducer module suitable for applying ultrasound therapy. The transducer module is suitable for ultrasound imaging and ultrasound therapy. The transducer module is suitable for coupling to an ultrasound probe. The transducer module includes a supersonic transducer, which is suitable for applying supersonic therapy to tissues at multiple locations at the depth of focus. The transducer module is adapted to be operatively coupled to at least one of a switch and a moving mechanism. The control module includes a processor and a display for controlling the transducer module.
在一個實施例中，換能器模組適於使用幅度調製施加超音治療，由此換能器模組的多個部分適於以多個聲強度幅度發射超音治療，其中第一幅度不同於第二個幅度。在一個實施例中，換能器模組適於施加超音治療，由此換能器模組的多個部分適於以多個聲強度相位發射超音治療，其中第一相位不同於第二相位。In one embodiment, the transducer module is adapted to apply ultrasound therapy using amplitude modulation, whereby portions of the transducer module are adapted to emit ultrasound therapy at multiple sound intensity amplitudes, where the first amplitude is different For the second range. In one embodiment, the transducer module is adapted to apply ultrasound therapy, whereby portions of the transducer module are adapted to emit ultrasound therapy in multiple sound intensity phases, where the first phase is different from the second Phase.
在各種實施例中，一種用於抖動多焦點治療的超音治療系統包括具有超音換能器的模組。超音換能器適於在組織中的多個間隔位置處同時對組織施加超音治療，其中模組經由第一聚焦區域和第二聚焦區域的抖動來修改多個間隔位置之間的間隔，使得經由頻率調製的抖動在多個間隔位置處精確地移動波束焦點的位置，其中模組還包括介面引導件，所述介面引導件被設計用於可去除地耦合到手持棒狀器以在模組和手持棒狀器之間提供電子通信和功率。In various embodiments, a supersonic therapy system for jitter multi-focus therapy includes a module with a supersonic transducer. The ultrasonic transducer is adapted to simultaneously apply ultrasonic treatment to the tissue at multiple spaced positions in the tissue, wherein the module modifies the spacing between the multiple spaced positions via the shaking of the first and second focus areas This allows the jitter via frequency modulation to accurately move the position of the beam focus at multiple spaced positions, where the module also includes an interface guide designed to be removably coupled to the handheld stick to Provide electronic communication and power between the group and the handheld stick.
在一個實施例中，超音換能器適於使用幅度調製施加超音治療，由此超音換能器的多個部分適於以多個聲強度幅度發射超音治療，其中第一幅度不同於第二幅度。在一個實施例中，超音換能器適於施加超音治療，由此超音換能器的多個部分適於以多個聲強度相位發射超音治療，其中第一相位不同於第二相位。在一個實施例中，超音換能器包括壓電材料，並且超音換能器的多個部分適於響應於施加到超音換能器的電場而產生多個相應的壓電材料變化。在一個實施例中，超音換能器的至少一部分適於以兩個或更多個聲強度幅度發射超音治療，並且其中由超音換能器的至少一部分發射的超音治療的幅度隨時間保持恆定。在一個實施例中，超音治療是面部提拉、眉毛提拉、下巴提拉、眼部治療（例如，顴骨袋、治療眶下鬆弛）、皺紋減少、肩部改善、臀部提拉、疤痕減少、燒傷治療、紋身去除、收緊皮膚（例如，腹部鬆弛治療或收緊身體和臉部其他區域的皮膚，例如任何多餘的皮膚或組織，例如在減肥期間或之後，例如，腹部、臀部、大腿、手臂和其他區域）、靜脈去除、靜脈減少、治療汗腺、治療多汗症、曬斑去除、脂肪治療、***修復和痤瘡治療。In one embodiment, the ultrasound transducer is adapted to apply ultrasound therapy using amplitude modulation, whereby portions of the ultrasound transducer are adapted to emit ultrasound therapy at multiple sound intensity amplitudes, where the first amplitude is different In the second range. In one embodiment, the ultrasound transducer is adapted to apply ultrasound therapy, whereby portions of the ultrasound transducer are adapted to emit ultrasound therapy in multiple sound intensity phases, where the first phase is different from the second Phase. In one embodiment, the ultrasonic transducer includes piezoelectric material, and portions of the ultrasonic transducer are adapted to produce a plurality of corresponding piezoelectric material changes in response to an electric field applied to the ultrasonic transducer. In one embodiment, at least a portion of the ultrasound transducer is adapted to emit ultrasound therapy at two or more sound intensity amplitudes, and wherein the amplitude of the ultrasound therapy emitted by at least a portion of the ultrasound transducer varies with The time remains constant. In one embodiment, the ultrasound treatment is facial lift, eyebrow lift, chin lift, eye treatment (eg, zygomatic pouch, treatment of suborbital sagging), wrinkle reduction, shoulder improvement, buttock lift, scar Reduction, burn treatment, tattoo removal, tightening of the skin (for example, abdominal relaxation treatment or tightening of the skin of the body and other areas of the face, such as any excess skin or tissue, for example during or after weight loss, for example, the abdomen, buttocks, Thighs, arms and other areas), vein removal, vein reduction, treatment of sweat glands, treatment of hyperhidrosis, sunburn removal, cellulite treatment, vaginal repair and acne treatment.
在各種實施例中，一種抖動同時聚焦的超音治療波束的方法包括提供包括超音換能器的超音探頭，所述超音換能器包括適於在焦深處的多個間隔位置處對組織同時施加超音治療的單個換能元件，以及耦合到超音探頭的控制模組，用於控制超音換能器，以及經由調製頻率抖動第一聚焦區域和第二聚焦區域的間隔位置之間的間隔以在間隔位置處移動超音焦點的位置。In various embodiments, a method of dithering a focused ultrasound treatment beam includes providing a ultrasound probe including a ultrasound transducer, the ultrasound transducer including a plurality of spaced locations adapted to be at a depth of focus A single transducer that simultaneously applies ultrasound treatment to the tissue, and a control module coupled to the ultrasound probe, used to control the ultrasound transducer, and to dither the space between the first focus area and the second focus area via the modulation frequency The interval between them moves the position of the supersonic focus at the interval position.
在一個實施例中，方法包括用超音成像元件成像第一聚焦區域。在一個實施例中，方法包括用超音成像元件成像第二聚焦區域。在一個實施例中，第一聚焦區域和第二聚焦區域之間的間隔在1-50％之間的範圍內抖動。在一個實施例中，第一聚焦區域和第二聚焦區域之間的間隔為1.5mm且上下浮動0.1mm。在一個實施例中，頻率調製在1-50％之間的範圍內。In one embodiment, the method includes imaging the first focus area with the ultrasound imaging element. In one embodiment, the method includes imaging the second focus area with the ultrasound imaging element. In one embodiment, the interval between the first focus area and the second focus area jitters in a range between 1-50%. In one embodiment, the interval between the first focus area and the second focus area is 1.5 mm and floats up and down 0.1 mm. In one embodiment, the frequency modulation is in the range between 1-50%.
在各種實施例中，一種抖動聚焦超音波束的方法包括提供包括單個換能元件的超音探頭和控制模組，其中單個換能元件適於在焦深處的聚焦區域處對組織施加超音治療，其中控制模組耦合到超音探頭以用於控制單個換能元件，並且經由調製頻率抖動聚焦區域以改變組織處的聚焦區域的尺寸。In various embodiments, a method of dithering a focused ultrasound beam includes providing a ultrasound probe and a control module including a single transducing element, wherein the single transducing element is adapted to apply ultrasound to tissue at a focus area at a depth of focus Treatment, where a control module is coupled to an ultrasound probe for controlling a single transducing element, and dithers the focus area via the modulation frequency to change the size of the focus area at the tissue.
在一個實施例中，聚焦區域的相對位置在1-50％之間的範圍內抖動。在一個實施例中，第二聚焦區域從單個換能元件同時發射。在一個實施例中，方法包括用超音成像元件對聚焦區域成像。在一個實施例中，頻率調製在1-50％的範圍內。In one embodiment, the relative position of the focus area jitters between 1-50%. In one embodiment, the second focus area is emitted simultaneously from a single transducing element. In one embodiment, the method includes imaging the focus area with the ultrasound imaging element. In one embodiment, the frequency modulation is in the range of 1-50%.
在各種實施例中，一種用超音換能器產生多個焦點和不同深度的超音治療系統包括超音探頭，所述超音探頭包括超音換能器，所述超音換能器配置成用由幅度調製極化和相移組成的組中的至少一種在具有至少兩個焦深的多個位置處對組織施加超音治療，移動機構，所述移動機構配置成被編程以提供多個單獨的美容治療區域之間的間隔；其中單獨的美容治療區域的序列具有在1mm至50mm範圍內的治療間隔，以及耦合到超音探頭的控制模組，用於控制超音換能器，其中超音換能器配置成提供在10W至1000W之間的範圍內的超音治療的聲功率和1MHz至20MHz頻率以通過熱加熱組織以引起凝固。在一個實施例中，多個位置以大致線性序列定位在美容治療區域內，並且超音換能器包括單個超音換能元件。在一個實施例中，第一組位置定位在第一美容治療區域內，並且第二組位置定位在第二美容治療區域內，第一區域不同於第二區域。在一個實施例中，第一美容治療區域包括第一組位置的大致線性序列，並且第二美容治療區域包括第二組位置的大致線性序列。在一個實施例中，超音換能器配置成使用幅度調製施加超音治療，由此超音換能器的多個部分配置成以多個聲強度幅度發射超音治療，其中第一幅度不同於第二幅度。In various embodiments, a supersonic therapy system using a supersonic transducer to generate multiple focal points and different depths includes a supersonic probe, the supersonic probe includes a supersonic transducer, and the supersonic transducer is configured At least one of the group consisting of amplitude modulation polarization and phase shift applies ultrasound treatment to the tissue at multiple locations with at least two focal depths, a movement mechanism configured to be programmed to provide multiple The interval between two individual beauty treatment areas; where the sequence of individual beauty treatment areas has a treatment interval in the range of 1 mm to 50 mm, and a control module coupled to the ultrasound probe for controlling the ultrasound transducer, The ultrasound transducer is configured to provide the sound power of ultrasound treatment in the range of 10W to 1000W and the frequency of 1MHz to 20MHz to heat the tissue by heat to cause coagulation. In one embodiment, multiple positions are positioned in a substantially linear sequence within the cosmetic treatment area, and the ultrasound transducer includes a single ultrasound transducer element. In one embodiment, the first set of locations is located within the first cosmetic treatment area, and the second set of locations is located within the second cosmetic treatment area, the first area is different from the second area. In one embodiment, the first cosmetic treatment area includes a substantially linear sequence of positions in the first set, and the second cosmetic treatment area includes a substantially linear sequence of positions in the second set. In one embodiment, the ultrasound transducer is configured to apply ultrasound therapy using amplitude modulation, whereby portions of the ultrasound transducer are configured to emit ultrasound therapy at multiple sound intensity amplitudes, where the first amplitude is different In the second range.
在一個實施例中，超音換能器配置成施加超音治療相移，由此超音換能器的多個部分配置成以多個聲強度相位發射超音治療，其中第一相位不同於第二相位。在一個實施例中，超音換能器配置成使用幅度調製施加超音治療，由此超音換能器的多個部分配置成以多個聲強度幅度發射超音治療，其中第一幅度不同於第二幅度；並且施加超音治療相移，由此超音換能器的多個部分配置成以多個聲強度相位發射超音治療，其中第一相位不同於第二相位。在一個實施例中，多個相位包括離散相位值。在一個實施例中，超音換能器包括壓電材料，並且超音換能器的多個部分配置成響應於施加到超音換能器的電場而產生多個相應的壓電材料變化。在一個實施例中，多個壓電材料變化包括壓電材料的膨脹和壓電材料的收縮中的至少一種。在一個實施例中，超音換能器的至少一部分配置成以兩個或更多個聲強度幅度發射超音治療，並且其中由壓電器的至少一部分發射的超音治療的幅度隨時間變化。在一個實施例中，移動機構配置成被編程以提供多個單獨的美容治療區域之間的可變間隔，還包括一個或多個可選擇的調諧電路。在一個實施例中，單獨的美容治療區域的序列具有在1mm至25mm的範圍內的治療間隔，還包括調諧電路。在一個實施例中，超音治療是面部提拉、眉毛提拉、下巴提拉、眼部治療、皺紋減少、疤痕減少、燒傷治療、皮膚收緊、靜脈減少、治療汗腺、治療多汗症、曬斑去除、脂肪治療、脂肪團治療、肩部治療、***修復和痤瘡治療中的至少一種。在一個實施例中，超音換能器配置成提供在10W至100W之間的範圍內的超音治療的聲功率和1MHz至12MHz的頻率以通過熱加熱組織以引起凝固。In one embodiment, the ultrasound transducer is configured to apply a ultrasound therapy phase shift, whereby portions of the ultrasound transducer are configured to emit ultrasound therapy with multiple sound intensity phases, where the first phase is different from The second phase. In one embodiment, the ultrasound transducer is configured to apply ultrasound therapy using amplitude modulation, whereby portions of the ultrasound transducer are configured to emit ultrasound therapy at multiple sound intensity amplitudes, where the first amplitude is different At a second amplitude; and applying a supersonic therapy phase shift, whereby portions of the supersonic transducer are configured to emit supersonic therapy with multiple sound intensity phases, where the first phase is different from the second phase. In one embodiment, the multiple phases include discrete phase values. In one embodiment, the ultrasonic transducer includes piezoelectric material, and portions of the ultrasonic transducer are configured to produce a plurality of corresponding piezoelectric material changes in response to an electric field applied to the ultrasonic transducer. In one embodiment, the plurality of piezoelectric material changes includes at least one of expansion of the piezoelectric material and contraction of the piezoelectric material. In one embodiment, at least a portion of the ultrasound transducer is configured to emit ultrasound therapy at two or more amplitudes of sound intensity, and wherein the amplitude of the ultrasound therapy emitted by at least a portion of the piezoelectric varies with time. In one embodiment, the movement mechanism is configured to be programmed to provide variable intervals between multiple individual cosmetic treatment areas and also includes one or more selectable tuning circuits. In one embodiment, the sequence of individual cosmetic treatment areas has treatment intervals in the range of 1 mm to 25 mm, and also includes a tuning circuit. In one embodiment, the ultrasound treatment is facial lift, eyebrow lift, chin lift, eye treatment, wrinkle reduction, scar reduction, burn treatment, skin tightening, vein reduction, treatment of sweat glands, treatment of hyperhidrosis, At least one of sunburn removal, cellulite treatment, cellulite treatment, shoulder treatment, vaginal repair, and acne treatment. In one embodiment, the ultrasound transducer is configured to provide the acoustic power of ultrasound treatment in the range between 10W and 100W and a frequency of 1MHz to 12MHz to heat the tissue by heat to cause coagulation.
在各種實施例中，一種用超音換能器在不同深度處同時產生多個焦點的治療系統，系統包括超音探頭，所述超音探頭具有可操作地控制用於提供超音成像的超音成像功能的第一開關，可操作地控制用於提供超音治療的超音治療功能的第二開關，以及配置成在單獨的熱美容治療區域的至少一個序列中引導超音治療的移動機構，以及配置成用由幅度調製極化和相移組成的組中的至少一種施加超音治療的換能器模組，其中換能器模組被配置用於超音成像和超音治療，其中換能器模組被配置用於耦合到超音探頭，其中換能器模組包括超音換能器，所述超音換能器配置成在具有至少兩個焦深的多個位置處對組織施加超音治療，其中換能器模組配置成可操作地耦合到第一開關，第二開關和移動機構中的至少一個；以及控制模組，其中控制模組包括處理器和顯示器，用於控制換能器模組。In various embodiments, a treatment system that uses ultrasound transducers to simultaneously generate multiple focal points at different depths, the system includes a ultrasound probe having an ultrasound operable to provide ultrasound imaging The first switch of the sound imaging function, the second switch operable to control the ultrasound treatment function for providing ultrasound treatment, and the moving mechanism configured to guide the ultrasound treatment in at least one sequence of the individual thermal cosmetic treatment areas , And a transducer module configured to apply ultrasound treatment with at least one of the group consisting of amplitude modulation polarization and phase shift, wherein the transducer module is configured for ultrasound imaging and ultrasound treatment, wherein The transducer module is configured for coupling to a supersonic probe, wherein the transducer module includes a supersonic transducer, the supersonic transducer configured to align at a plurality of positions having at least two focal depths Tissue application ultrasound treatment, wherein the transducer module is configured to be operatively coupled to at least one of the first switch, the second switch, and the moving mechanism; and the control module, wherein the control module includes a processor and a display, Used to control the transducer module.
在一個實施例中，超音治療是美容治療，其中多個位置以大致線性序列定位在美容治療區域內。在一個實施例中，超音治療是美容治療，其中第一組位置定位在第一治療區域內，並且第二組位置定位在第二治療區域內，第一區域不同於第二區域。在一個實施例中，第一治療區域包括第一組位置的大致線性序列，並且第二治療區域包括第二組位置的大致線性序列。在一個實施例中，換能器模組配置成使用幅度調製施加超音治療，由此換能器模組的多個部分配置成以多個聲強度幅度發射超音治療，其中第一幅度不同於第二幅度。在一個實施例中，換能器模組配置成施加超音治療相移，由此換能器模組的多個部分配置成以多個聲強度相位發射超音治療，其中第一相位不同於第二相位。在一個實施例中，換能器模組配置成使用幅度調製施加超音治療，由此換能器模組的多個部分配置成以多個聲強度幅度發射超音治療，其中第一幅度不同於第二幅度；並且施加超音治療相移，由此換能器模組的多個部分配置成以多個聲強度相位發射超音治療，其中第一相位不同於第二相位。在一個實施例中，多個相位包括離散相位值。在一個實施例中，換能器模組包括壓電材料，並且換能器模組的多個部分配置成響應於施加到換能器模組的電場而產生多個相應的壓電材料變化。在一個實施例中，多個壓電材料變化包括材料的膨脹和材料的收縮中的至少一種。在一個實施例中，換能器模組的至少一部分配置成以兩個或更多個聲強度幅度發射超音治療，並且其中由換能器模組的至少一部分發射的超音治療的幅度隨時間變化。在一個實施例中，移動機構配置成被編程以提供多個單獨的熱美容治療區域之間的可變間隔。在一個實施例中，單獨的美容治療區域的序列具有在1mm至25mm的範圍內的治療間隔。在一個實施例中，第一和第二開關包括使用者操作按鈕或鍵。在一個實施例中，第一開關和第二開關中的至少一個由控制模組激活。在一個實施例中，超音治療是面部提拉、眉毛提拉、下巴提拉、眼部治療、皺紋減少、疤痕減少、燒傷治療、紋身去除、皮膚收緊、靜脈去除、靜脈減少、治療汗腺、治療多汗症、曬斑去除、脂肪治療、脂肪團治療、肩部治療、***修復和痤瘡治療中的至少一種。在一個實施例中，換能器模組配置成提供在10W至1000W之間的範圍內的超音治療的聲功率和1MHz至20MHz的頻率以通過熱加熱組織以引起凝固。In one embodiment, the ultrasound treatment is a cosmetic treatment, where multiple positions are positioned within the cosmetic treatment area in a substantially linear sequence. In one embodiment, the ultrasound treatment is a cosmetic treatment, where the first group of positions is positioned within the first treatment area and the second group of positions is positioned within the second treatment area, the first area being different from the second area. In one embodiment, the first treatment area includes a substantially linear sequence of positions in the first set, and the second treatment area includes a substantially linear sequence of positions in the second set. In one embodiment, the transducer module is configured to apply ultrasound therapy using amplitude modulation, whereby portions of the transducer module are configured to emit ultrasound therapy at multiple sound intensity amplitudes, where the first amplitude is different In the second range. In one embodiment, the transducer module is configured to apply ultrasound treatment phase shift, whereby portions of the transducer module are configured to emit ultrasound treatment with multiple sound intensity phases, wherein the first phase is different from The second phase. In one embodiment, the transducer module is configured to apply ultrasound therapy using amplitude modulation, whereby portions of the transducer module are configured to emit ultrasound therapy at multiple sound intensity amplitudes, where the first amplitude is different At a second amplitude; and applying a supersonic therapy phase shift, whereby portions of the transducer module are configured to emit supersonic therapy with multiple sound intensity phases, where the first phase is different from the second phase. In one embodiment, the multiple phases include discrete phase values. In one embodiment, the transducer module includes piezoelectric material, and portions of the transducer module are configured to generate a plurality of corresponding piezoelectric material changes in response to an electric field applied to the transducer module. In one embodiment, the plurality of piezoelectric material changes includes at least one of expansion of the material and contraction of the material. In one embodiment, at least a portion of the transducer module is configured to emit ultrasound therapy at two or more sound intensity amplitudes, and wherein the amplitude of the ultrasound therapy emitted by at least a portion of the transducer module varies with Change of time. In one embodiment, the movement mechanism is configured to be programmed to provide a variable interval between multiple individual thermal cosmetic treatment areas. In one embodiment, the sequence of individual cosmetic treatment areas has treatment intervals in the range of 1 mm to 25 mm. In one embodiment, the first and second switches include user-operated buttons or keys. In one embodiment, at least one of the first switch and the second switch is activated by the control module. In one embodiment, the ultrasound treatment is facial lift, eyebrow lift, chin lift, eye treatment, wrinkle reduction, scar reduction, burn treatment, tattoo removal, skin tightening, vein removal, vein reduction, treatment of sweat glands , At least one of hyperhidrosis treatment, sunburn removal, cellulite treatment, cellulite treatment, shoulder treatment, vaginal repair and acne treatment. In one embodiment, the transducer module is configured to provide acoustic power for ultrasound treatment in the range between 10W and 1000W and a frequency of 1MHz to 20MHz to heat the tissue by heat to cause coagulation.
在各種實施例中，一種用於在多個深度處遞送同時治療的治療系統，系統包括可操作地控制用於提供超音治療的超音治療功能的控制裝置；以及配置成在單獨的熱美容治療區域的序列中引導超音治療的手持棒狀器，手持棒狀器包括配置成在焦深處的位置處對組織施加超音治療的換能器，位置定位在熱美容治療區域內，其中換能器還配置成在焦深處的多個位置處同時對組織施加超音治療。In various embodiments, a treatment system for delivering simultaneous treatments at multiple depths, the system includes a control device operable to control the ultrasound treatment function for providing ultrasound treatment; A hand-held stick to guide ultrasound treatment in the sequence of treatment areas, the hand-held stick includes a transducer configured to apply ultrasound treatment to tissue at a position at a depth of focus, the position being positioned within the thermal beauty treatment area, wherein The transducer is also configured to simultaneously apply ultrasound treatment to the tissue at multiple locations at the depth of focus.
在各種實施例中，一種通過用單個換能器在多個深度處產生多個同時焦點在皮膚上執行非侵入性美容程序的方法，方法包括將換能器模組與超音探頭耦合；其中超音探頭包括控制聲學成像的第一開關；其中超音探頭包括控制聲學治療以用於導致多個單獨的美容治療區域的第二開關；其中超音探頭包括提供單獨的美容治療區域之間的期望間隔的移動機構；使換能器模組與受試者的皮膚表面接觸；激活超音探頭上的第一個開關以用換能器模組聲學成像皮膚表面下方的區域；以及激活超音探頭上的第二開關以用換能器模組在由移動機構控制的單獨的美容治療區域的期望序列中聲學治療皮膚表面下方的區域，其中換能器模組包括配置成在多個焦深處對組織施加超音治療的單個超音換能器。In various embodiments, a method of performing a non-invasive cosmetic procedure on the skin by generating multiple simultaneous focal points at multiple depths with a single transducer, the method comprising coupling the transducer module with an ultrasound probe; wherein The ultrasound probe includes a first switch that controls acoustic imaging; wherein the ultrasound probe includes a second switch that controls acoustic therapy for causing a plurality of separate cosmetic treatment areas; wherein the ultrasound probe includes a switch between providing separate cosmetic treatment areas Moving mechanism at desired intervals; bringing the transducer module into contact with the skin surface of the subject; activating the first switch on the ultrasound probe to acoustically image the area under the skin surface with the transducer module; and activating the ultrasound A second switch on the probe to acoustically treat the area under the skin surface with a transducer module in a desired sequence of individual cosmetic treatment areas controlled by the movement mechanism, wherein the transducer module includes a plurality of focal depths A single ultrasound transducer that applies ultrasound treatment to the tissue.
在各種實施例中，一種用超音換能器在組織中的多個深度處同時產生多個焦點的超音治療系統，系統包括可操作地控制用於提供超音治療的超音治療功能的控制裝置；以及配置成在單獨的熱美容治療區域的序列中引導超音治療的手持棒狀器，手持棒狀器包括：配置成在焦深處的多個位置處對組織施加超音治療的換能器。In various embodiments, a supersonic therapy system using a supersonic transducer to simultaneously generate multiple focal points at multiple depths in a tissue, the system includes an operable control of a supersonic therapy function for providing supersonic therapy A control device; and a hand-held stick configured to guide ultrasound treatment in a sequence of separate thermal cosmetic treatment areas, the hand-held stick comprising: a device configured to apply ultrasound treatment to tissue at multiple locations at a depth of focus Transducer.
在各種實施例中，一種用於組織中的多個深度處的美容治療的成像和治療系統，系統包括配置用於多個焦深處的組織的超音成像和超音治療的超音探頭，包括配置用於耦合到超音探頭的換能器模組，其中換能器模組包括配置成在焦深處的多個位置處對組織施加超音治療的超音換能器，可操作地控制用於提供超音成像的超音成像功能的第一開關；可操作地控制用於提供超音治療的超音治療功能的第二開關；以及配置成在單獨的熱美容治療區域的至少一個序列中引導超音治療的移動機構；並且其中換能器模組配置成可操作地耦合到第一開關、第二開關和移動機構中的至少一個；以及控制模組，其中控制模組包括處理器和顯示器，用於控制換能器模組。In various embodiments, an imaging and treatment system for cosmetic treatment at multiple depths in a tissue, the system includes a ultrasonic probe configured for ultrasonic imaging and ultrasonic treatment of tissue at multiple focal depths, Includes a transducer module configured for coupling to a ultrasound probe, where the transducer module includes a ultrasound transducer configured to apply ultrasound treatment to tissue at multiple locations at the depth of focus, operably A first switch to control a supersonic imaging function for providing supersonic imaging; a second switch to operably control a supersonic therapy function for providing supersonic therapy; and at least one configured to be in a separate thermal beauty treatment area A moving mechanism that guides ultrasound therapy in the sequence; and wherein the transducer module is configured to be operatively coupled to at least one of the first switch, the second switch, and the moving mechanism; and a control module, wherein the control module includes processing Transducer and display, used to control the transducer module.
在一個實施例中，多個位置以大致線性序列定位在美容治療區域內。在一個實施例中，第一組位置定位在第一美容治療區域內，並且第二組位置定位在第二美容治療區域內，第一區域不同於第二區域。在一個實施例中，第一美容治療區域包括第一組位置的大致線性序列，並且第二美容治療區域包括第二組位置的大致線性序列。在一個實施例中，換能器模組配置成使用幅度調製施加超音治療，由此換能器模組的多個部分配置成以多個聲強度幅度發射超音治療，其中第一幅度不同於第二幅度。在一個實施例中，換能器模組配置成施加超音治療相移，由此換能器模組的多個部分配置成以多個聲強度相位發射超音治療，其中第一相位不同於第二相位。在一個實施例中，換能器模組配置成使用幅度調製施加超音治療，由此換能器模組的多個部分配置成以多個聲強度幅度發射超音治療，其中第一幅度不同於第二幅度；並且施加超音治療相移，由此換能器模組的多個部分配置成以多個聲強度相位發射超音治療，其中第一相位不同於第二相位。在一個實施例中，多個相位包括離散相位值。在一個實施例中，換能器模組包括壓電材料，並且換能器模組的多個部分配置成響應於施加到換能器模組的電場而產生多個相應的壓電材料變化。在一個實施例中，多個壓電材料變化包括材料的膨脹和材料的收縮中的至少一種。在一個實施例中，換能器模組的至少一部分配置成以兩個或更多個聲強度幅度發射超音治療，並且其中由換能器模組的至少一部分發射的超音治療的幅度隨時間變化。在一個實施例中，移動機構配置成被編程以提供多個單獨的熱美容治療區域之間的可變間隔。在一個實施例中，單獨的熱美容治療區域的序列具有在0.01mm至25mm的範圍內的治療間隔。在一個實施例中，第一和第二開關包括使用者操作按鈕或鍵。在一個實施例中，第一開關和第二開關中的至少一個由控制模組激活。在一個實施例中，治療功能是面部提拉、眉毛提拉、下巴提拉、眼部治療、皺紋減少、疤痕減少、燒傷治療、紋身去除、皮膚收緊、靜脈去除、靜脈減少、治療汗腺、治療多汗症、曬斑去除、脂肪治療、***修復和痤瘡治療中的至少一種。在一個實施例中，換能器模組配置成提供在10W至1000W之間的範圍內的超音治療的聲功率和1MHz至10MHz的頻率以通過熱加熱組織以引起凝固。In one embodiment, multiple locations are positioned within the cosmetic treatment area in a substantially linear sequence. In one embodiment, the first set of locations is located within the first cosmetic treatment area, and the second set of locations is located within the second cosmetic treatment area, the first area is different from the second area. In one embodiment, the first cosmetic treatment area includes a substantially linear sequence of positions in the first set, and the second cosmetic treatment area includes a substantially linear sequence of positions in the second set. In one embodiment, the transducer module is configured to apply ultrasound therapy using amplitude modulation, whereby portions of the transducer module are configured to emit ultrasound therapy at multiple sound intensity amplitudes, where the first amplitude is different In the second range. In one embodiment, the transducer module is configured to apply ultrasound treatment phase shift, whereby portions of the transducer module are configured to emit ultrasound treatment with multiple sound intensity phases, wherein the first phase is different from The second phase. In one embodiment, the transducer module is configured to apply ultrasound therapy using amplitude modulation, whereby portions of the transducer module are configured to emit ultrasound therapy at multiple sound intensity amplitudes, where the first amplitude is different At a second amplitude; and applying a supersonic therapy phase shift, whereby portions of the transducer module are configured to emit supersonic therapy with multiple sound intensity phases, where the first phase is different from the second phase. In one embodiment, the multiple phases include discrete phase values. In one embodiment, the transducer module includes piezoelectric material, and portions of the transducer module are configured to generate a plurality of corresponding piezoelectric material changes in response to an electric field applied to the transducer module. In one embodiment, the plurality of piezoelectric material changes includes at least one of expansion of the material and contraction of the material. In one embodiment, at least a portion of the transducer module is configured to emit ultrasound therapy at two or more sound intensity amplitudes, and wherein the amplitude of the ultrasound therapy emitted by at least a portion of the transducer module varies with Change of time. In one embodiment, the movement mechanism is configured to be programmed to provide a variable interval between multiple individual thermal cosmetic treatment areas. In one embodiment, the sequence of individual thermal cosmetic treatment areas has treatment intervals in the range of 0.01 mm to 25 mm. In one embodiment, the first and second switches include user-operated buttons or keys. In one embodiment, at least one of the first switch and the second switch is activated by the control module. In one embodiment, the treatment function is facial lift, eyebrow lift, chin lift, eye treatment, wrinkle reduction, scar reduction, burn treatment, tattoo removal, skin tightening, vein removal, vein reduction, treatment of sweat glands, Treatment of at least one of hyperhidrosis, sunburn removal, cellulite treatment, vaginal repair, and acne treatment. In one embodiment, the transducer module is configured to provide acoustic power for ultrasound treatment in the range between 10W and 1000W and a frequency of 1MHz to 10MHz to heat the tissue by heat to cause coagulation.
在各種實施例中，一種用於在多個深度處同時治療的多焦點超音治療系統，系統包括可操作地控制用於提供超音治療的超音治療功能的控制裝置；配置成在單獨的熱美容治療區域的序列中引導超音治療的手持棒狀器，手持棒狀器包括配置成在焦深處的位置處對組織施加超音治療的換能器，位置定位在熱美容治療區域內，其中換能器還配置成在焦深處的多個位置處同時對組織施加超音治療。In various embodiments, a multi-focus ultrasound treatment system for simultaneous treatment at multiple depths, the system includes a control device operable to control a ultrasound treatment function for providing ultrasound treatment; A hand-held stick that guides ultrasound treatment in the sequence of the thermal beauty treatment area, the hand stick includes a transducer configured to apply ultrasound treatment to the tissue at a position at the depth of focus, and the position is positioned within the thermal beauty treatment area , Where the transducer is also configured to simultaneously apply ultrasound treatment to the tissue at multiple locations at the depth of focus.
在各種實施例中，在多個深度處的成像和同時多焦點治療系統包括具有超音換能器的模組，其中超音換能器配置成用由幅度調製極化和相移組成的組中的至少一種在多個焦深處對組織施加超音治療，其中模組還包括介面引導件，所述介面引導件被設計用於可去除地耦合到手持棒狀器以在模組和手持棒狀器之間提供電子通信和功率。In various embodiments, the imaging and simultaneous multi-focus treatment system at multiple depths includes a module with a supersonic transducer, where the supersonic transducer is configured with a group consisting of amplitude modulation polarization and phase shift At least one of the two applies ultrasonic treatment to the tissue at multiple depths of focus, wherein the module further includes an interface guide designed to be removably coupled to the handheld stick to hold the module and the handheld Provide electronic communication and power between rods.
在一個實施例中，多個位置以大致線性序列定位在美容治療區域內。在一個實施例中，第一組位置定位在第一美容治療區域內，並且第二組位置定位在第二美容治療區域內，第一區域不同於第二區域。在一個實施例中，第一美容治療區域包括第一組位置的大致線性序列，並且第二美容治療區域包括第二組位置的大致線性序列。在一個實施例中，超音換能器配置成使用幅度調製施加超音治療，由此超音換能器的多個部分配置成以多個聲強度幅度發射超音治療，其中第一幅度不同於第二幅度。在一個實施例中，超音換能器配置成施加超音治療相移，由此超音換能器的多個部分配置成以多個聲強度相位發射超音治療，其中第一相位不同於第二相位。在一個實施例中，超音換能器配置成使用幅度調製施加超音治療，由此超音換能器的多個部分配置成以多個聲強度幅度發射超音治療，其中第一幅度不同於第二幅度；並且施加超音治療相移，由此超音換能器的多個部分配置成以多個聲強度相位發射超音治療，其中第一相位不同於第二相位。在一個實施例中，多個相位包括離散相位值。在一個實施例中，超音換能器包括壓電材料，並且超音換能器的多個部分配置成響應於施加到超音換能器的電場而產生多個相應的壓電材料變化。在一個實施例中，多個壓電材料變化包括壓電材料的膨脹和壓電材料的收縮中的至少一種。在一個實施例中，超音換能器的至少一部分配置成以兩個或更多個聲強度幅度發射超音治療，並且其中由壓電器的至少一部分發射的超音治療的幅度隨時間變化。在一個實施例中，成像和治療系統包括移動機構，所述移動機構配置成被編程以提供多個單獨的美容治療區域之間的間隔。在一個實施例中，單獨的美容治療區域的序列具有在1mm至50mm的範圍內的治療間隔。在一個實施例中，超音治療是面部提拉，眉毛提拉，下巴提拉，眼部治療，皺紋減少，疤痕減少，燒傷治療，紋身去除，皮膚收緊，靜脈去除，靜脈減少，治療汗腺，治療多汗症，曬斑去除，脂肪治療，***修復和痤瘡治療中的至少一種。在一個實施例中，超音換能器配置成提供在1W至100W的範圍內的超音治療的聲功率和1MHz至10MHz的頻率以通過熱加熱組織以引起凝固。In one embodiment, multiple locations are positioned within the cosmetic treatment area in a substantially linear sequence. In one embodiment, the first set of locations is located within the first cosmetic treatment area, and the second set of locations is located within the second cosmetic treatment area, the first area is different from the second area. In one embodiment, the first cosmetic treatment area includes a substantially linear sequence of positions in the first set, and the second cosmetic treatment area includes a substantially linear sequence of positions in the second set. In one embodiment, the ultrasound transducer is configured to apply ultrasound therapy using amplitude modulation, whereby portions of the ultrasound transducer are configured to emit ultrasound therapy at multiple sound intensity amplitudes, where the first amplitude is different In the second range. In one embodiment, the ultrasound transducer is configured to apply a ultrasound therapy phase shift, whereby portions of the ultrasound transducer are configured to emit ultrasound therapy with multiple sound intensity phases, where the first phase is different from The second phase. In one embodiment, the ultrasound transducer is configured to apply ultrasound therapy using amplitude modulation, whereby portions of the ultrasound transducer are configured to emit ultrasound therapy at multiple sound intensity amplitudes, where the first amplitude is different At a second amplitude; and applying a supersonic therapy phase shift, whereby portions of the supersonic transducer are configured to emit supersonic therapy with multiple sound intensity phases, where the first phase is different from the second phase. In one embodiment, the multiple phases include discrete phase values. In one embodiment, the ultrasonic transducer includes piezoelectric material, and portions of the ultrasonic transducer are configured to produce a plurality of corresponding piezoelectric material changes in response to an electric field applied to the ultrasonic transducer. In one embodiment, the plurality of piezoelectric material changes includes at least one of expansion of the piezoelectric material and contraction of the piezoelectric material. In one embodiment, at least a portion of the ultrasound transducer is configured to emit ultrasound therapy at two or more amplitudes of sound intensity, and wherein the amplitude of the ultrasound therapy emitted by at least a portion of the piezoelectric varies with time. In one embodiment, the imaging and treatment system includes a movement mechanism configured to be programmed to provide spacing between multiple individual cosmetic treatment areas. In one embodiment, the sequence of individual cosmetic treatment areas has treatment intervals in the range of 1 mm to 50 mm. In one embodiment, the ultrasound treatment is facial lift, eyebrow lift, chin lift, eye treatment, wrinkle reduction, scar reduction, burn treatment, tattoo removal, skin tightening, vein removal, vein reduction, sweat glands , At least one of hyperhidrosis treatment, sunburn removal, cellulite treatment, vaginal repair and acne treatment. In one embodiment, the ultrasound transducer is configured to provide the acoustic power of ultrasound treatment in the range of 1W to 100W and a frequency of 1MHz to 10MHz to heat the tissue by heat to cause coagulation.
在各種實施例中，一種用於在多個深度處同時治療的治療系統，系統包括：可操作地控制用於提供超音治療的超音治療功能的控制裝置；以及配置成在單獨的熱美容治療區域的序列中引導超音治療的手持棒狀器，手持棒狀器包括配置成在焦深處的多個位置處同時對組織施加超音治療的換能器。In various embodiments, a treatment system for simultaneous treatment at multiple depths, the system includes: a control device operable to control a supersonic treatment function for providing supersonic treatment; A hand-held stick that guides ultrasound treatment in the sequence of treatment areas, the hand stick includes a transducer configured to simultaneously apply ultrasound treatment to tissue at multiple locations at the depth of focus.
在各種實施例中，一種不由醫生執行的在多個深度處同時執行美容手術的非侵入性方法，方法包括將換能器模組與超音探頭耦合；其中所述換能器模組包括超音換能器，所述超音換能器配置成用由幅度調製極化和相移組成的組中的至少一種在焦深處的多個位置處對組織施加超音治療，其中超音探頭包括控制聲學成像的第一開關；其中超音探頭包括控制聲學治療以用於導致多個單獨的美容治療區域的第二開關；其中超音探頭包括提供單獨的美容治療區域之間的期望間隔的移動機構；使換能器模組與受試者的皮膚表面接觸；激活超音探頭上的第一個開關以用換能器模組聲學成像皮膚表面下方的區域；以及激活超音探頭上的第二開關以用換能器模組在由移動機構控制的單獨的美容治療區域的期望序列中聲學治療皮膚表面下方的區域。In various embodiments, a non-invasive method of performing cosmetic surgery at multiple depths that is not performed by a doctor, the method includes coupling a transducer module with an ultrasound probe; wherein the transducer module includes a super A sound transducer configured to apply ultrasound treatment to tissue at multiple positions at a depth of focus with at least one of the group consisting of amplitude modulation polarization and phase shift, wherein the ultrasound probe Includes a first switch to control acoustic imaging; wherein the ultrasound probe includes a second switch to control acoustic therapy for causing multiple separate cosmetic treatment areas; wherein the ultrasound probe includes a switch to provide a desired interval between the individual cosmetic treatment areas Moving mechanism; bringing the transducer module into contact with the skin surface of the subject; activating the first switch on the ultrasound probe to acoustically image the area under the skin surface with the transducer module; and activating the ultrasound probe The second switch uses the transducer module to acoustically treat the area under the skin surface in the desired sequence of individual cosmetic treatment areas controlled by the movement mechanism.
在各種實施例中，一種用於在多個深度處抖動來自超音換能器的多個同時焦點的超音治療系統包括超音探頭，所述超音探頭包括具有單個換能元件的超音換能器，所述單個換能元件適於在多個間隔焦深處同時對組織施加超音治療，其中超音換能器用至少第一極化配置和第二極化配置極化，耦合到超音探頭的控制模組，用於控制超音換能器，其中控制模組經由第一聚焦區域和第二聚焦區域的抖動修改間隔位置之間的間隔，使得經由頻率調製的抖動在間隔位置處精確地移動波束焦點的位置。In various embodiments, a supersonic therapy system for shaking multiple simultaneous focal points from a supersonic transducer at multiple depths includes a supersonic probe that includes a supersonic with a single transducing element A transducer, the single transducer element is adapted to simultaneously apply ultrasound treatment to tissue at multiple spaced focal depths, wherein the ultrasound transducer is polarized with at least a first polarization configuration and a second polarization configuration, coupled to The control module of the ultrasonic probe is used to control the ultrasonic transducer, wherein the control module modifies the interval between the interval positions via the jitter of the first focus area and the second focus area so that the jitter via frequency modulation is at the interval position Move the position of the beam focus precisely.
在一個實施例中，多個位置以線性序列定位在美容治療區域內，其中間隔位置以經由頻率擺動抖動的間隔分離。在一個實施例中，第一組位置定位在第一美容治療區域內，並且第二組位置定位在第二美容治療區域內，第一區域不同於第二區域。在一個實施例中，超音換能器適於使用幅度調製施加超音治療，由此超音換能器的多個部分適於以多個聲強度幅度發射超音治療，其中第一幅度不同於第二幅度。在一個實施例中，超音換能器的至少一部分適於以兩個或更多個聲強度幅度發射超音治療，並且其中由壓電器的至少一部分發射的超音治療的幅度隨時間變化。在一個實施例中，超音換能器包括壓電材料，並且超音換能器的多個部分適於響應於施加到超音換能器的電場而產生多個相應的壓電材料變化。在一個實施例中，多個壓電材料變化包括壓電材料的膨脹和壓電材料的收縮中的至少一種。在一個實施例中，超音換能器適於經由相移施加超音治療，由此超音換能器的多個部分適於以多個聲強度相位發射超音治療，其中第一相位不同於第二相位。在一個實施例中，多個相位包括離散相位值。在一個實施例中，超音換能器適於使用幅度調製施加超音治療，由此超音換能器的多個部分適於以多個聲強度幅度發射超音治療，其中第一幅度不同於第二幅度；並且施加超音治療，其中超音換能器的多個部分適於以多個聲強度相位發射超音治療，其中第一相位不同於第二相位。在一個實施例中，超音治療是以下中的至少一種：面部提拉、眉毛提拉、下巴提拉、眼部治療、皺紋減少、肩部改善、臀部提拉、疤痕減少、燒傷治療、皮膚收緊、血管減少、治療汗腺、曬斑去除、脂肪治療、腹部鬆弛治療和脂肪團治療。在一個實施例中，超音探頭包括移動機構，所述移動機構適於在單獨的熱美容治療區域的至少一對同時序列中引導超音治療。在一個實施例中，超音探頭被配置用於超音成像和超音治療。在一個實施例中，超音探頭包括適於施加超音治療的換能器模組。In one embodiment, a plurality of positions are positioned within the cosmetic treatment area in a linear sequence, where the spaced positions are separated at intervals that are shaken via frequency swings. In one embodiment, the first set of locations is located within the first cosmetic treatment area, and the second set of locations is located within the second cosmetic treatment area, the first area is different from the second area. In one embodiment, the ultrasound transducer is adapted to apply ultrasound therapy using amplitude modulation, whereby portions of the ultrasound transducer are adapted to emit ultrasound therapy at multiple sound intensity amplitudes, where the first amplitude is different In the second range. In one embodiment, at least a portion of the ultrasound transducer is adapted to emit ultrasound therapy at two or more amplitudes of sound intensity, and wherein the amplitude of the ultrasound therapy emitted by at least a portion of the piezoelectric device changes over time. In one embodiment, the ultrasonic transducer includes piezoelectric material, and portions of the ultrasonic transducer are adapted to produce a plurality of corresponding piezoelectric material changes in response to an electric field applied to the ultrasonic transducer. In one embodiment, the plurality of piezoelectric material changes includes at least one of expansion of the piezoelectric material and contraction of the piezoelectric material. In one embodiment, the ultrasound transducer is adapted to apply ultrasound therapy via phase shift, whereby portions of the ultrasound transducer are adapted to emit ultrasound therapy in multiple sound intensity phases, where the first phase is different In the second phase. In one embodiment, the multiple phases include discrete phase values. In one embodiment, the ultrasound transducer is adapted to apply ultrasound therapy using amplitude modulation, whereby portions of the ultrasound transducer are adapted to emit ultrasound therapy at multiple sound intensity amplitudes, where the first amplitude is different At a second amplitude; and applying ultrasound therapy, wherein portions of the ultrasound transducer are adapted to emit ultrasound therapy in multiple sound intensity phases, where the first phase is different from the second phase. In one embodiment, the ultrasound treatment is at least one of the following: facial lifting, eyebrow lifting, chin lifting, eye treatment, wrinkle reduction, shoulder improvement, hip lifting, scar reduction, burn treatment, skin Tightening, blood vessel reduction, treatment of sweat glands, sunburn removal, cellulite treatment, abdominal relaxation treatment and cellulite treatment. In one embodiment, the ultrasound probe includes a movement mechanism adapted to guide ultrasound treatment in at least one pair of simultaneous sequences of separate thermal cosmetic treatment areas. In one embodiment, the ultrasound probe is configured for ultrasound imaging and ultrasound therapy. In one embodiment, the ultrasound probe includes a transducer module suitable for applying ultrasound therapy.
在各種實施例中，一種在美容治療中用於抖動來自超音換能器的多個深度處的多個同時焦點的超音治療系統，系統包括超音探頭，所述超音探頭具有適於經由抖動修改第一聚焦區域和第二聚焦區域之間的間隔的控制模組，可操作地控制用於提供超音治療的超音治療功能的開關；以及適於在單獨的熱美容治療區域的至少一對同時序列中引導超音治療的移動機構；以及適於施加超音治療的換能器模組，其中換能器模組適用於超音成像和超音治療，其中換能器模組適於耦合到超音探頭，其中換能器模組包括適於在具有至少兩個焦深的多個位置處對組織施加超音治療的超音換能器，其中換能器模組適於可操作地耦合到開關和移動機構中的至少一個；並且其中控制模組包括處理器和顯示器，用於控制換能器模組。In various embodiments, a supersonic therapy system for shaking multiple simultaneous focal points at multiple depths from a supersonic transducer in cosmetic treatment, the system includes a supersonic probe having A control module that modifies the interval between the first focus area and the second focus area via dithering, operable to control a switch for providing a supersonic therapy function for supersonic therapy; and suitable for a separate thermal cosmetic treatment area At least one pair of moving mechanisms to guide ultrasound therapy in a simultaneous sequence; and a transducer module suitable for applying ultrasound therapy, wherein the transducer module is suitable for ultrasound imaging and ultrasound therapy, wherein the transducer module Suitable for coupling to an ultrasound probe, wherein the transducer module includes an ultrasound transducer adapted to apply ultrasound treatment to tissue at a plurality of positions having at least two focal depths, wherein the transducer module is adapted Operatively coupled to at least one of a switch and a moving mechanism; and wherein the control module includes a processor and a display for controlling the transducer module.
在一個實施例中，換能器模組適於使用幅度調製施加超音治療，由此換能器模組的多個部分適於以多個聲強度幅度發射超音治療，其中第一幅度不同於第二個幅度。在一個實施例中，換能器模組適於施加超音治療，由此換能器模組的多個部分適於以多個聲強度相位發射超音治療，其中第一相位不同於第二相位。In one embodiment, the transducer module is adapted to apply ultrasound therapy using amplitude modulation, whereby portions of the transducer module are adapted to emit ultrasound therapy at multiple sound intensity amplitudes, where the first amplitude is different For the second range. In one embodiment, the transducer module is adapted to apply ultrasound therapy, whereby portions of the transducer module are adapted to emit ultrasound therapy in multiple sound intensity phases, where the first phase is different from the second Phase.
在各種實施例中，一種用於在多個深度處抖動同時多焦點治療的超音治療系統包括具有超音換能器的模組，其中超音換能器適於在組織中的多個間隔深度處同時對組織施加超音治療，其中模組經由第一聚焦區域和第二聚焦區域的抖動修改多個間隔深度之間的間隔，使得經由頻率調製的抖動在多個間隔深度處精確地移動波束焦點的位置，其中模組還包括介面引導件，所述介面引導件被設計用於可去除地耦合到手持棒狀器以在模組和手持棒狀器之間提供電子通信和功率。In various embodiments, a ultrasound treatment system for simultaneous multi-focus treatment at multiple depths of vibration includes a module with a ultrasound transducer, wherein the ultrasound transducer is adapted to multiple intervals in the tissue Ultrasound therapy is applied to the tissue at the same time at the depth, where the module modifies the interval between the multiple interval depths via the jitter of the first focus area and the second focus area so that the jitter via frequency modulation moves accurately at the multiple interval depth The location of the beam focus, where the module also includes an interface guide designed to be removably coupled to the handheld stick to provide electronic communication and power between the module and the handheld stick.
在一個實施例中，超音換能器適於使用幅度調製施加超音治療，由此超音換能器的多個部分適於以多個聲強度幅度發射超音治療，其中第一幅度不同於第二個幅度。在一個實施例中，超音換能器適於施加超音治療，由此超音換能器的多個部分適於以多個聲強度相位發射超音治療，其中第一相位不同於第二相位。在一個實施例中，超音換能器包括壓電材料，並且超音換能器的多個部分適於響應於施加到超音換能器的電場而產生多個相應的壓電材料變化。在一個實施例中，超音換能器的至少一部分適於以兩個或更多個聲強度幅度發射超音治療，並且其中由超音換能器的至少一部分發射的超音治療的幅度隨時間保持恆定。在一個實施例中，超音治療是面部提拉、眉毛提拉、下巴提拉、眼部治療、皺紋減少、肩部改善、臀部提拉、疤痕減少、燒傷治療、紋身去除、皮膚收緊、靜脈去除、靜脈減少、治療汗腺、治療多汗症、曬斑去除、脂肪治療、脂肪團治療、腹部鬆弛治療、***修復和痤瘡治療中的至少一種。In one embodiment, the ultrasound transducer is adapted to apply ultrasound therapy using amplitude modulation, whereby portions of the ultrasound transducer are adapted to emit ultrasound therapy at multiple sound intensity amplitudes, where the first amplitude is different For the second range. In one embodiment, the ultrasound transducer is adapted to apply ultrasound therapy, whereby portions of the ultrasound transducer are adapted to emit ultrasound therapy in multiple sound intensity phases, where the first phase is different from the second Phase. In one embodiment, the ultrasonic transducer includes piezoelectric material, and portions of the ultrasonic transducer are adapted to produce a plurality of corresponding piezoelectric material changes in response to an electric field applied to the ultrasonic transducer. In one embodiment, at least a portion of the ultrasound transducer is adapted to emit ultrasound therapy at two or more sound intensity amplitudes, and wherein the amplitude of the ultrasound therapy emitted by at least a portion of the ultrasound transducer varies with The time remains constant. In one embodiment, the ultrasound treatment is facial lift, eyebrow lift, chin lift, eye treatment, wrinkle reduction, shoulder improvement, hip lift, scar reduction, burn treatment, tattoo removal, skin tightening, At least one of vein removal, vein reduction, treatment of sweat glands, treatment of hyperhidrosis, sunburn removal, cellulite treatment, cellulite treatment, abdominal relaxation treatment, vaginal repair and acne treatment.
在各種實施例中，一種在多個深度處抖動同時聚焦超音治療波束的方法包括提供包括超音換能器的超音探頭，所述超音換能器包括適於在多個焦深處的多個間隔位置處同時對組織施加超音治療的單個換能元件，和耦合到超音探頭的控制模組，用於控制超音換能器，以及經由頻率調製抖動第一聚焦區域和第二聚焦區域的間隔位置之間的間隔以在間隔位置處移動超音焦點的位置。In various embodiments, a method of dithering at multiple depths while focusing a supersonic therapy beam includes providing a supersonic probe that includes a supersonic transducer, the supersonic transducer including a plurality of depths of focus A single transducer element that simultaneously applies ultrasound treatment to the tissue at multiple spaced locations of the device, and a control module coupled to the ultrasound probe, is used to control the ultrasound transducer, and dither the first focus area and the first via frequency modulation The interval between the interval positions of the two focus areas is to move the position of the supersonic focus at the interval position.
在一個實施例中，方法還包括用超音成像元件成像第一聚焦區域。在一個實施例中，方法還包括用超音成像元件成像第二聚焦區域。在一個實施例中，第一聚焦區域和第二聚焦區域之間的間隔在1-50％之間的範圍內抖動。在一個實施例中，第一聚焦區域和第二聚焦區域之間的間隔為1.5mm且上下浮動0.1mm。在一個實施例中，頻率調製在1-50％之間的範圍內。在一個實施例中，超音治療是面部提拉、眉毛提拉、下巴提拉、眼部治療、皺紋減少、肩部改善、臀部提拉、疤痕減少、燒傷治療、紋身去除、皮膚收緊、靜脈去除、靜脈減少、治療汗腺、治療多汗症、曬斑去除、脂肪治療、***修復、腹部鬆弛治療和痤瘡治療中的至少一種。In one embodiment, the method further includes imaging the first focus area with the ultrasound imaging element. In one embodiment, the method further includes imaging the second focus area with the ultrasound imaging element. In one embodiment, the interval between the first focus area and the second focus area jitters in a range between 1-50%. In one embodiment, the interval between the first focus area and the second focus area is 1.5 mm and floats up and down 0.1 mm. In one embodiment, the frequency modulation is in the range between 1-50%. In one embodiment, the ultrasound treatment is facial lift, eyebrow lift, chin lift, eye treatment, wrinkle reduction, shoulder improvement, hip lift, scar reduction, burn treatment, tattoo removal, skin tightening, At least one of vein removal, vein reduction, treatment of sweat glands, treatment of hyperhidrosis, sunburn removal, fat treatment, vaginal repair, abdominal relaxation treatment, and acne treatment.
在各種實施例中，一種在多個深度處同時抖動聚焦超音波束的方法包括提供包括單個換能元件的超音探頭和控制模組，其中單個換能元件適於在焦深處的聚焦區域處對組織施加超音治療，其中控制模組耦合到超音探頭以用於控制單個換能元件，以及經由頻率調製抖動聚焦區域以改變組織處的聚焦區域的尺寸。In various embodiments, a method of simultaneously dithering a focused ultrasound beam at multiple depths includes providing a ultrasound probe and a control module including a single transducing element, wherein the single transducing element is adapted to the focus area at the depth of focus Ultrasound therapy is applied to the tissue at the site, where a control module is coupled to the ultrasound probe for controlling a single transducing element, and dithering the focus area via frequency modulation to change the size of the focus area at the tissue.
在一個實施例中，聚焦區域的相對位置在1-50％之間的範圍內抖動。在一個實施例中，第二聚焦區域從單個換能元件同時發射。在一個實施例中，頻率調製在1-50％之間的範圍內。在一個實施例中，系統被設計成非侵入性地工作以治療組織。在一個實施例中，方法以非侵入性方式起作用以治療組織。In one embodiment, the relative position of the focus area jitters between 1-50%. In one embodiment, the second focus area is emitted simultaneously from a single transducing element. In one embodiment, the frequency modulation is in the range between 1-50%. In one embodiment, the system is designed to work non-invasively to treat tissue. In one embodiment, the method functions in a non-invasive manner to treat tissue.
在各種實施例中，一種用電致伸縮器在多個深度處遞送同時多焦點治療的超音治療系統，所述電致伸縮器包括具有超音換能器的模組，其中超音換能器適於通過電致伸縮器的應用在組織中的多個間隔深度處同時對組織施加超音治療，其中模組經由第一聚焦區域和第二聚焦區域的抖動修改多個間隔深度之間的間隔，使得經由頻率調製的抖動在多個間隔深度處精確地移動波束焦點的位置，其中模組還包括介面引導件，所述介面引導件被設計用於可去除地耦合到手持棒狀器以在模組和手持棒狀器之間提供電子通信和功率。In various embodiments, a supersonic therapy system that delivers simultaneous multifocal therapy at multiple depths with an electrostrictor, the electrostrictor includes a module with a supersonic transducer, wherein the supersonic transducer The device is suitable for applying ultrasound treatment to the tissue at multiple intervals in the tissue at the same time through the application of the electrostrictor, wherein the module modifies the interval between the multiple intervals through the shaking of the first and second focus areas Spacing so that the frequency-modulated jitter accurately moves the position of the beam focus at multiple depths of space, where the module also includes an interface guide designed to be removably coupled to the handheld stick to Provide electronic communication and power between the module and the handheld stick.
在一個實施例中，超音換能器適於使用幅度調製施加超音治療，由此超音換能器的多個部分適於以多個聲強度幅度發射超音治療，其中第一幅度不同於第二個幅度。在一個實施例中，超音換能器適於施加超音治療，由此超音換能器的多個部分適於以多個聲強度相位發射超音治療，其中第一相位不同於第二相位。在一個實施例中，超音換能器包括壓電材料，並且超音換能器的多個部分適於響應於施加到超音換能器的電場而產生多個相應的壓電材料變化。在一個實施例中，超音換能器的至少一部分適於以兩個或更多個聲強度幅度發射超音治療，並且其中由超音換能器的至少一部分發射的超音治療的幅度隨時間保持恆定。在一個實施例中，超音治療是面部提拉、眉毛提拉、下巴提拉、眼部治療、皺紋減少、肩部改善、臀部提拉、疤痕減少、燒傷治療、紋身去除、皮膚收緊、靜脈去除、靜脈減少、治療汗腺、治療多汗症、曬斑去除、脂肪治療、脂肪團治療、腹部鬆弛治療、***修復和痤瘡治療中的至少一種。In one embodiment, the ultrasound transducer is adapted to apply ultrasound therapy using amplitude modulation, whereby portions of the ultrasound transducer are adapted to emit ultrasound therapy at multiple sound intensity amplitudes, where the first amplitude is different For the second range. In one embodiment, the ultrasound transducer is adapted to apply ultrasound therapy, whereby portions of the ultrasound transducer are adapted to emit ultrasound therapy in multiple sound intensity phases, where the first phase is different from the second Phase. In one embodiment, the ultrasonic transducer includes piezoelectric material, and portions of the ultrasonic transducer are adapted to produce a plurality of corresponding piezoelectric material changes in response to an electric field applied to the ultrasonic transducer. In one embodiment, at least a portion of the ultrasound transducer is adapted to emit ultrasound therapy at two or more sound intensity amplitudes, and wherein the amplitude of the ultrasound therapy emitted by at least a portion of the ultrasound transducer varies with The time remains constant. In one embodiment, the ultrasound treatment is facial lift, eyebrow lift, chin lift, eye treatment, wrinkle reduction, shoulder improvement, hip lift, scar reduction, burn treatment, tattoo removal, skin tightening, At least one of vein removal, vein reduction, treatment of sweat glands, treatment of hyperhidrosis, sunburn removal, cellulite treatment, cellulite treatment, abdominal relaxation treatment, vaginal repair and acne treatment.
在各種實施例中，提供了一種超音治療系統，其具有說明書中描述的一個或多個特徵。在各種實施例中，提供了一種減少移動超音換能器中的成像未對準的方法，其具有說明書中描述的一個或多個特徵。在各種實施例中，提供了一種用於從超音換能器產生多個同時焦點的超音治療系統，其具有說明書中描述的一個或多個特徵。在各種實施例中，提供了一種用於遞送多焦點治療的超音治療系統，其具有說明書中描述的一個或多個特徵。在各種實施例中，提供了一種在美容治療中用於從超音換能器形成多個同時聚焦區域的超音治療模組，其具有說明書中描述的一個或多個特徵。在各種實施例中，提供了一種使用多通道信號混合生成同時聚焦超音治療波束的方法，其具有說明書中描述的一個或多個特徵。在各種實施例中，提供了一種生成同時聚焦超音波束的方法，其具有說明書中描述的一個或多個特徵。In various embodiments, an ultrasound treatment system is provided that has one or more features described in the specification. In various embodiments, a method for reducing imaging misalignment in a mobile ultrasound transducer is provided, which has one or more features described in the specification. In various embodiments, a supersonic therapy system for generating multiple simultaneous focal points from a supersonic transducer is provided, which has one or more features described in the specification. In various embodiments, a supersonic therapy system for delivering multi-focus therapy is provided, which has one or more features described in the specification. In various embodiments, a supersonic therapy module for forming multiple simultaneous focus areas from a supersonic transducer in cosmetic treatment is provided, which has one or more features described in the specification. In various embodiments, a method for using a multi-channel signal mixture to generate a simultaneous focused ultrasound therapy beam is provided, which has one or more features described in the specification. In various embodiments, a method of generating simultaneously focused ultrasound beams is provided, which has one or more features described in the specification.
在本文描述的若干實施例中，程序完全是美容的而不是醫療行為。例如，在一個實施例中，本文描述的方法不需要由醫生執行，而是在spa或其他美容機構處執行。在一些實施例中，系統可以用於皮膚的非侵入性美容治療。In several embodiments described herein, the procedure is entirely cosmetic rather than medical. For example, in one embodiment, the method described herein does not need to be performed by a doctor, but is performed at a spa or other beauty facility. In some embodiments, the system can be used for non-invasive cosmetic treatment of skin.
以上概述並在下面進一步詳細闡述的方法描述了從業者採取的某些動作；然而，應當理解它們還可以包括另一方對這些行為的指示。因此，諸如“抖動能量波束”的動作包括“指示能量波束的抖動”。The methods outlined above and further elaborated below describe certain actions taken by practitioners; however, it should be understood that they may also include an indication of these actions by another party. Therefore, actions such as "dithering the energy beam" include "indicating the dithering of the energy beam".
在一些實施例中，系統包括作為單個特徵（與多個特徵相反）存在的各種特徵。例如，在一個實施例中，系統包括單個換能元件，其產生抖動的兩個同時治療焦點。在備選實施例中提供了多個特徵或部件。在各種實施例中，系統包含、基本上組成為或者組成為本文公開的任何特徵或部件的一個、兩個、三個或更多個實施例。在一些實施例中，特徵或部件不被包括並且可以從特定申請專利範圍否定地放棄，使得系統沒有這樣的特徵或部件。In some embodiments, the system includes various features that exist as a single feature (as opposed to multiple features). For example, in one embodiment, the system includes a single transducing element that produces two simultaneous treatment focal points for shaking. In alternative embodiments, multiple features or components are provided. In various embodiments, the system includes, consists essentially of, or consists of one, two, three, or more embodiments of any feature or component disclosed herein. In some embodiments, features or components are not included and can be negated from the scope of a specific patent application so that the system does not have such features or components.
此外，從本文提供的描述將顯而易見適用領域。應當理解，描述和具體示例僅用於說明目的，並不旨在限制本文公開的實施例的範圍。In addition, the field of application will be apparent from the description provided herein. It should be understood that the description and specific examples are for illustrative purposes only and are not intended to limit the scope of the embodiments disclosed herein.
以下描述闡述了實施例的示例，並且不旨在限制本發明或其教導、應用或其用途。應當理解在整個附圖中，相應的附圖標記表示相同或相應的部件和特徵。在本發明的各種實施例中指示的具體實施例的描述僅用於說明目的，並不意圖限制本文公開的本發明的範圍。而且，具有所述特徵的多個實施例的敘述並不旨在排除具有附加特徵的其他實施例或包含所述特徵的不同組合的其他實施例。此外，一個實施例中的特徵（例如在一個圖中）可以與其他實施例的描述（和圖）組合。The following description sets forth examples of embodiments and is not intended to limit the invention or its teachings, applications, or uses. It should be understood that throughout the drawings, corresponding reference numerals indicate the same or corresponding parts and features. The descriptions of specific embodiments indicated in the various embodiments of the present invention are for illustrative purposes only and are not intended to limit the scope of the present invention disclosed herein. Moreover, the recitation of multiple embodiments having the described features is not intended to exclude other embodiments having additional features or other embodiments containing different combinations of the described features. In addition, features in one embodiment (eg, in one figure) can be combined with descriptions (and figures) of other embodiments.
在各種實施例中，用於組織的超音治療的系統和方法適於和/或配置成提供美容治療。在一些實施例中，在若干實施例中提供了裝置和方法，其將超音治療引導到單個焦點或多個同時焦點，採用超音成像來確認到治療區域的足夠聲學耦合以改善性能或當在美容和/或醫療程序中形成圖像時提供第一和第二方向上的移動之間的改善相關性。在如本文所用的各種實施例中，“同時”是指同時發生，或者時間差小於1ms、0.5ms、0.1ms、0.05ms或0.01ms。在各種實施例中，用超音能量非侵入性地治療皮膚表面下方或甚至皮膚表面處的組織，例如表皮、真皮、筋膜、肌肉、脂肪和淺表肌肉腱膜系統（“SMAS”）。超音能量可以聚焦在一個或多個治療點和/或區域，可以是未聚焦的和/或散焦的，並且可以施加到包含表皮、真皮、下皮、筋膜、肌肉、脂肪、脂肪團和SMAS中的至少一種的感興趣區域以實現美容和/或治療效果。在各種實施例中，系統和/或方法通過熱處理、凝固、消融和/或收緊向組織提供非侵入性皮膚治療。在本文公開的若干實施例中，非侵入性超音用於實現以下效果中的一種或多種：面部提拉、眉毛提拉、下巴提拉、眼部治療（例如，顴骨袋、治療眶下鬆弛）、皺紋減少、脂肪減少（例如，脂肪和/或脂肪團的治療）、脂肪團治療（例如，凹陷或非凹陷型女性脂肪營養不良）、肩部改善（例如，上胸）、臀部提拉（例如，臀部收緊）、皮膚鬆弛治療（例如治療組織以用於收緊或腹部鬆弛治療）、疤痕減少、燒傷治療、紋身去除、靜脈去除、靜脈減少、治療汗腺、治療多汗症、曬斑去除、痤瘡治療和丘疹去除。在一個實施例中，實現脂肪減少。在各種實施例中，與例如未治療的組織相比，一種或多種特性（例如凹陷、結節、“橘皮”外觀等）的脂肪團（例如，凹陷或非凹陷型女性脂肪營養不良）減少或改善達到約10-20％、20-40％、40-60％、60-80％或以上（以及其中的重疊範圍）。在一個實施例中，治療肩部。在一些實施例中，兩個、三個或更多個有益效果在相同的治療療程實現，並且可以同時實現。In various embodiments, systems and methods for ultrasound treatment of tissues are suitable and / or configured to provide cosmetic treatments. In some embodiments, in several embodiments, devices and methods are provided that direct ultrasound therapy to a single focus or multiple simultaneous focal points, using ultrasound imaging to confirm sufficient acoustic coupling to the treatment area to improve performance or when Provides improved correlation between movement in the first and second directions when forming images in cosmetic and / or medical procedures. In various embodiments as used herein, "simultaneously" means occurring simultaneously, or the time difference is less than 1 ms, 0.5 ms, 0.1 ms, 0.05 ms, or 0.01 ms. In various embodiments, ultrasound energy is used to non-invasively treat tissues below or even at the skin surface, such as the epidermis, dermis, fascia, muscle, fat, and superficial muscle aponeurotic system ("SMAS"). Ultrasonic energy can be focused on one or more treatment points and / or areas, can be unfocused and / or defocused, and can be applied to the epidermis, dermis, hypodermis, fascia, muscle, fat, cellulite And at least one of SMAS to achieve a cosmetic and / or therapeutic effect. In various embodiments, the system and / or method provides non-invasive skin treatment to the tissue through heat treatment, coagulation, ablation, and / or tightening. In several embodiments disclosed herein, non-invasive ultrasound is used to achieve one or more of the following effects: facial lift, eyebrow lift, chin lift, eye treatment (eg, zygomatic pouch, treatment of suborbital Sagging), wrinkle reduction, fat loss (for example, treatment of fat and / or cellulite), cellulite treatment (for example, concave or non-recessed female fat malnutrition), shoulder improvement (for example, upper chest), buttock lift Pulling (e.g. hip tightening), skin relaxation treatment (e.g. treating tissue for tightening or abdominal relaxation treatment), scar reduction, burn treatment, tattoo removal, vein removal, vein reduction, treatment of sweat glands, treatment of hyperhidrosis, Sunburn removal, acne treatment and pimple removal. In one embodiment, fat reduction is achieved. In various embodiments, one or more characteristics (eg, depression, nodules, "orange peel" appearance, etc.) of cellulite (eg, depression or non-pitting female lipodystrophy) is reduced or compared to, for example, untreated tissue The improvement reached about 10-20%, 20-40%, 40-60%, 60-80% or more (and the overlapping range among them). In one embodiment, the shoulder is treated. In some embodiments, two, three, or more beneficial effects are achieved in the same treatment course, and can be achieved simultaneously.
本發明的各種實施例涉及控制向組織遞送能量的裝置或方法。在各種實施例中，各種形式的能量可以包括聲、超音、光、雷射、射頻（RF）、微波、電磁、輻射、熱、低溫、電子束、基於光子、磁、磁共振和/或其他能量形式。本發明的各種實施例涉及將超音能量波束***成多個波束的裝置或方法。在各種實施例中，裝置或方法可以用於在任何程序中改變超音聲能的遞送，例如但不限於治療超音、診斷超音、超音焊接、涉及將機械波耦合到物體的任何應用以及其他程序。通常，利用治療超音，通過集中來自孔徑的使用聚焦技術的聲能來實現組織效應。在一些情況下，高強度聚焦超音（HIFU）以該方式用於治療目的。在一個實施例中，通過在特定深度處施加治療超音而產生的組織效應可以被稱為熱凝固點（TCP）的產生。在一些實施例中，區域可以包括點。在一些實施例中，區域是線、平面、球形、橢圓形、立方形或其他一維、二維或三維形狀。通過在特定位置處產生TCP，組織的熱和/或機械消融可以非侵入性地或遠程地發生。在一些實施例中，超音治療不包括空化和/或衝擊波。在一些實施例中，超音治療包括空化和/或衝擊波。Various embodiments of the invention relate to devices or methods for controlling the delivery of energy to tissue. In various embodiments, various forms of energy may include sound, ultrasound, light, laser, radio frequency (RF), microwave, electromagnetic, radiation, heat, low temperature, electron beam, photon-based, magnetic, magnetic resonance and / or Other energy forms. Various embodiments of the present invention relate to an apparatus or method for splitting a supersonic energy beam into multiple beams. In various embodiments, the device or method may be used to change the delivery of ultrasound sound energy in any procedure, such as but not limited to therapeutic ultrasound, diagnostic ultrasound, ultrasound welding, any application involving coupling of mechanical waves to objects And other programs. Typically, with therapeutic ultrasound, tissue effects are achieved by focusing the acoustic energy from the aperture using focusing technology. In some cases, high-intensity focused ultrasound (HIFU) is used in this way for therapeutic purposes. In one embodiment, the tissue effect generated by applying therapeutic ultrasound at a specific depth may be referred to as the generation of thermal freezing point (TCP). In some embodiments, the area may include dots. In some embodiments, the area is a line, plane, sphere, ellipse, cube, or other one-dimensional, two-dimensional, or three-dimensional shape. By generating TCP at specific locations, thermal and / or mechanical ablation of tissue can occur non-invasively or remotely. In some embodiments, ultrasound therapy does not include cavitation and / or shock waves. In some embodiments, ultrasound therapy includes cavitation and / or shock waves.
在一個實施例中，TCP可以以線性或大致線性，彎曲或大致彎曲的區域或序列產生，其中每個單獨的TCP通過治療間隔與相鄰TCP分離。在一個實施例中，可以在治療區域中產生多個TCP序列。例如，可以沿著第一序列和與第一序列分離治療距離的第二序列形成TCP。儘管可以通過在單獨的TCP的一個和多個序列中產生單獨的TCP來施用治療超音的治療，但是可能期望減少治療時間和患者所經歷的疼痛和/或不適的相應風險。通過同時，幾乎同時或依序地形成多個TCP可以減少治療時間。在一些實施例中，通過產生多個TCP，治療時間可以減少10％、20％、25％、30％、35％、40％、45％、50％、55％、60％、65％、70％、75％、80％或以上。In one embodiment, TCPs can be produced in linear or approximately linear, curved or approximately curved regions or sequences, where each individual TCP is separated from adjacent TCPs by treatment intervals. In one embodiment, multiple TCP sequences can be generated in the treatment area. For example, the TCP may be formed along the first sequence and the second sequence separated from the first sequence by a therapeutic distance. Although it is possible to administer the treatment of ultrasound by generating individual TCPs in one or more sequences of individual TCPs, it may be desirable to reduce the treatment time and the corresponding risk of pain and / or discomfort experienced by the patient. By simultaneously, forming multiple TCPs almost simultaneously or sequentially can reduce the treatment time. In some embodiments, by generating multiple TCPs, treatment time can be reduced by 10%, 20%, 25%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, 70 %, 75%, 80% or more.
本發明的各種實施例解決了施用超音治療所帶來的潛在挑戰。在各種實施例中，減少了用於在靶組織處實現期望的臨床方法的所需美容和/或治療處理的TCP形成的時間。在各種實施例中，靶組織是，但不限於以下的任何一種：皮膚、眼瞼、眼睫毛、眉毛、淚小管、魚尾紋、皺紋、眼、鼻、口（例如，鼻唇溝、口周皺紋）、舌頭、牙齒、牙齦、耳朵、腦、心臟、肺、肋骨、腹部（例如，用於腹部鬆弛）、胃、肝臟、腎臟、子宮、***、***、***、睾丸、腺體、甲狀腺、內臟、頭髮、肌肉、骨骼、韌帶、軟骨、脂肪、脂肪葉、脂肪組織、皮下組織、植入組織、植入器官、淋巴、腫瘤、囊腫、膿腫或神經的一部分或其任何組合。Various embodiments of the present invention address the potential challenges posed by the application of ultrasound therapy. In various embodiments, the time to TCP formation for the required cosmetic and / or therapeutic treatment of the desired clinical method at the target tissue is reduced. In various embodiments, the target tissue is, but is not limited to, any of the following: skin, eyelid, eyelashes, eyebrows, lacrimal tubules, crow's feet, wrinkles, eyes, nose, mouth (eg, nasolabial folds, wrinkles around the mouth), Tongue, teeth, gums, ears, brain, heart, lungs, ribs, abdomen (for example, for abdominal relaxation), stomach, liver, kidney, uterus, breast, vagina, prostate, testicles, glands, thyroid, internal organs, hair , Muscle, bone, ligament, cartilage, fat, fat leaf, adipose tissue, subcutaneous tissue, implanted tissue, implanted organ, lymph, tumor, cyst, abscess, or part of nerve or any combination thereof.
組織中的多個位置處的同時超音治療的各種實施例在2014年9月11日公佈為美國公開第2014/0257145號的美國申請案第14/193,234號中描述，其通過引用整體併入本文。
系統概述 Various embodiments of simultaneous ultrasound treatment at multiple locations in the organization are described in US Application No. 14 / 193,234, published on September 11, 2014 as U.S. Publication No. 2014/0257145, which is incorporated by reference in its entirety This article.
System Overview
參考圖1A、1B和1C，超音系統20的各種實施例包括手持棒狀器（hand wand）（例如，手持機（handpiece））100、模組（例如，換能器模組、盒、探頭）200和控制器（例如，控制台）300。在一些實施例中，控制台300包括通信系統（例如，wifi、藍牙、調變解調器等）以與另一方、製造商、供應商、服務提供商、網際網路和/或雲端進行通信。在一些實施例中，推車301提供系統20的移動性和/或位置，並且可以包括輪子、在其上書寫或放置部件的表面和/或隔室302（例如，抽屜、容器、擱架等），以便例如儲存或整理部件。在一些實施例中，推車具有電源，例如到電池的電源連接和/或將電力、通信（例如，以太網）連接到系統20的一根或多根電線。在一些實施例中，系統20包括推車301。在一些實施例中，系統20不包括推車301。手持棒狀器100可以通過介面130耦合到控制器300，所述介面可以是有線或無線介面。介面130可以通過連接器145耦合到手持棒狀器100。介面130的遠端可以連接到電路345（未示出）上的控制器連接器。在一個實施例中，介面130可以將可控制的功率從控制器300傳輸到手持棒狀器100。在一個實施例中，系統20具有多個成像通道（例如，8個通道），用於皮下結構的超清晰HD（高清晰度）可視化以改善成像。在一個實施例中，系統20包括多個治療通道（例如，8個通道）和精確線性驅動電機，其在提高速度（例如，25％、40％、50％、60％、75％、100％或以上）的同時使治療精度加倍。這些特徵一起建立了業界最通用的系統平臺之一並且為前所未有的未來可能性奠定了基礎。1A, 1B, and 1C, various embodiments of the ultrasound system 20 include a hand wand (eg, handpiece) 100, a module (eg, a transducer module, a box, a probe) ) 200 and controller (for example, console) 300. In some embodiments, the console 300 includes a communication system (eg, wifi, Bluetooth, modem, etc.) to communicate with another party, manufacturer, supplier, service provider, Internet, and / or cloud . In some embodiments, the cart 301 provides the mobility and / or location of the system 20, and may include wheels, surfaces on which to write or place components, and / or compartments 302 (eg, drawers, containers, shelves, etc.) ), For example to store or organize parts. In some embodiments, the cart has a power source, such as a power connection to a battery and / or one or more wires that connect power, communications (eg, Ethernet) to the system 20. In some embodiments, the system 20 includes a cart 301. In some embodiments, the system 20 does not include a cart 301. The handheld stick 100 may be coupled to the controller 300 through an interface 130, which may be a wired or wireless interface. The interface 130 may be coupled to the handheld stick 100 through the connector 145. The distal end of the interface 130 may be connected to a controller connector on the circuit 345 (not shown). In one embodiment, the interface 130 may transfer controllable power from the controller 300 to the handheld stick 100. In one embodiment, the system 20 has multiple imaging channels (eg, 8 channels) for ultra-clear HD (high definition) visualization of subcutaneous structures to improve imaging. In one embodiment, the system 20 includes multiple treatment channels (eg, 8 channels) and precision linear drive motors that increase speed (eg, 25%, 40%, 50%, 60%, 75%, 100%) Or more) while doubling the accuracy of treatment. Together, these features establish one of the industry's most versatile system platforms and lay the foundation for unprecedented future possibilities.
在各種實施例中，控制器300可以適於和/或配置用於與手持棒狀器100和模組200以及整個超音系統20的功能一起操作。在各種實施例中，多個控制器300、300'、300''等可以適於和/或配置用於與多個手持棒狀器100、100'、100''等和/或多個模組200、200'、200''等一起操作。控制器300可以包括到一個或多個交互式圖形顯示器310的連接性，所述圖形顯示器可以包括允許使用者與超音系統20交互的觸控螢幕監視器和圖形使用者介面（GUI）。在一個實施例中，第二更小，更移動的顯示屏允許使用者更容易地定位和查看治療螢幕。在一個實施例中，第二顯示器允許系統使用者查看治療螢幕（例如，在牆壁上、在移動設備上、大螢幕、遠程螢幕）。在一個實施例中，圖形顯示器310包括觸控螢幕介面315（未示出）。在各種實施例中，顯示器310設置和顯示操作條件，包括設備激活狀態、治療參數、系統消息和提示以及超音圖像。在各種實施例中，控制器300可以適於和/或配置成包括例如具有軟件和輸入/輸出裝置的微處理器、用於控制電子和/或機械掃描和/或換能器的多工處理和/或換能器模組的多工處理的系統和裝置、用於功率輸送的系統、用於監測的系統、用於感測探頭和/或換能器的空間位置和/或換能器模組的多工處理的系統、和/或用於處理使用者輸入和記錄治療結果的系統等等。在各種實施例中，控制器300可以包括系統處理器和各種模擬和/或數字控制邏輯，如微控制器、微處理器、現場可程式閘陣列、計算機板和相關部件中的一個或多個，包括固件和控制軟件，其可以能夠與使用者控件和介面電路以及輸入/輸出電路和用於通信、顯示、界接、存儲、文件編制和其他有用功能的系統介面。在系統進程上運行的系統軟件可以適於和/或配置成控制所有初始化、定時、等級設置、監測、安全監測以及用於實現使用者定義的治療目標的所有其他超音系統功能。此外，控制器300可以包括各種輸入/輸出模組，例如開關、按鈕等，其也可以合適地適於和/或配置成控制超音系統20的操作。In various embodiments, the controller 300 may be adapted and / or configured to operate with the functions of the handheld stick 100 and the module 200 and the entire ultrasound system 20. In various embodiments, multiple controllers 300, 300 ', 300 ", etc. may be adapted and / or configured for interfacing with multiple handheld sticks 100, 100', 100", etc. and / or multiple modules Groups 200, 200 ', 200' ', etc. operate together. The controller 300 may include connectivity to one or more interactive graphical displays 310, which may include a touch screen monitor and a graphical user interface (GUI) that allow users to interact with the ultrasound system 20. In one embodiment, the second smaller, more mobile display screen allows the user to more easily locate and view the treatment screen. In one embodiment, the second display allows the system user to view the treatment screen (eg, on the wall, on the mobile device, large screen, remote screen). In one embodiment, the graphic display 310 includes a touch screen interface 315 (not shown). In various embodiments, the display 310 sets and displays operating conditions, including device activation status, treatment parameters, system messages and prompts, and ultrasound images. In various embodiments, the controller 300 may be adapted and / or configured to include, for example, a microprocessor with software and input / output devices, multiplexing processing for controlling electronic and / or mechanical scanning and / or transducers And / or multiplex processing systems and devices for transducer modules, systems for power delivery, systems for monitoring, spatial positions for sensing probes and / or transducers and / or transducers A system for multiplex processing of modules, and / or a system for processing user input and recording treatment results, etc. In various embodiments, the controller 300 may include a system processor and various analog and / or digital control logic, such as one or more of a microcontroller, a microprocessor, a field programmable gate array, a computer board, and related components , Including firmware and control software, which may be able to interface with user controls and interface circuits as well as input / output circuits and system interfaces for communication, display, interface, storage, documentation, and other useful functions. The system software running on the system process may be adapted and / or configured to control all initialization, timing, level setting, monitoring, safety monitoring, and all other ultrasound system functions for achieving user-defined treatment goals. In addition, the controller 300 may include various input / output modules, such as switches, buttons, etc., which may also be suitably adapted and / or configured to control the operation of the ultrasound system 20.
在一個實施例中，手持棒狀器100包括一個或多個手指激活的控制器或開關，例如150和160。在各種實施例中，一個或多個熱處理控制器160（例如，開關、按鈕）啟動和/或停止治療。在各種實施例中，一個或多個成像控制器150（例如，開關、按鈕）啟動和/或停止成像。在一個實施例中，手持棒狀器100可以包括可去除模組200。在其他實施例中，模組200可以是不可去除的。在各種實施例中，模組200可以使用閂鎖或耦合器140機械地耦合到手持棒狀器100。在各種實施例中，介面引導件235或多個介面引導件235可用於幫助將模組200耦合到手持棒狀器100。模組200可以包括一個或多個超音換能器280。在一些實施例中，超音換能器280包括一個或多個超音元件。模組200可以包括一個或多個超音元件。手持棒狀器100可以包括僅成像模組，僅治療模組，成像和治療模組等。在各種實施例中，超音換能器280在模組200內在一個或多個方向290上可移動。換能器280連接到運動機構400。在各種實施例中，運動機構包括零個、一個或多個軸承、軸、杆、螺杆、導螺杆401、編碼器402（例如，測量換能器280的位置的光學編碼器）、電機403（例如，步進電機）以幫助確保換能器280在模組200內的準確且可重複的移動。在各種實施例中，模組200可以包括換能器280，所述換能器可以通過聲學透明構件230發射能量。在一個實施例中，控制模組300可以經由介面130耦合到手持棒狀器100，並且圖形使用者介面310可以適於和/或配置用於控制模組200。在一個實施例中，控制模組300可以向手持棒狀器100提供功率。在一個實施例中，手持棒狀器100可以包括電源。在一個實施例中，開關150可以適於和/或配置用於控制組織成像功能，並且開關160可以適於和/或配置用於控制組織治療功能。在各種實施例中，模組200通過換能器280的控制系統300的受控操作來提供以合適的焦深、分佈、定時和能量水平遞送發射能量50以用熱凝固區域550（“TCP”，例如，熱凝固點）實現期望的治療效果。In one embodiment, the handheld stick 100 includes one or more finger-activated controllers or switches, such as 150 and 160. In various embodiments, one or more heat treatment controllers 160 (eg, switches, buttons) start and / or stop treatment. In various embodiments, one or more imaging controllers 150 (eg, switches, buttons) start and / or stop imaging. In one embodiment, the handheld stick 100 may include a removable module 200. In other embodiments, the module 200 may not be removable. In various embodiments, the module 200 may be mechanically coupled to the handheld stick 100 using a latch or coupler 140. In various embodiments, the interface guide 235 or multiple interface guides 235 may be used to help couple the module 200 to the handheld stick 100. The module 200 may include one or more ultrasonic transducers 280. In some embodiments, the ultrasound transducer 280 includes one or more ultrasound elements. The module 200 may include one or more ultrasonic components. The handheld stick 100 may include an imaging module only, a treatment module only, an imaging and treatment module, and so on. In various embodiments, the ultrasound transducer 280 is movable in one or more directions 290 within the module 200. The transducer 280 is connected to the movement mechanism 400. In various embodiments, the motion mechanism includes zero, one or more bearings, shafts, rods, screws, lead screws 401, encoder 402 (eg, an optical encoder that measures the position of the transducer 280), and a motor 403 ( For example, a stepper motor) to help ensure accurate and repeatable movement of the transducer 280 within the module 200. In various embodiments, the module 200 may include a transducer 280 that may emit energy through the acoustically transparent member 230. In one embodiment, the control module 300 may be coupled to the handheld stick 100 via the interface 130, and the graphical user interface 310 may be adapted and / or configured for the control module 200. In one embodiment, the control module 300 may provide power to the handheld stick 100. In one embodiment, the handheld stick 100 may include a power source. In one embodiment, the switch 150 may be adapted and / or configured to control tissue imaging functions, and the switch 160 may be adapted and / or configured to control tissue treatment functions. In various embodiments, the module 200 provides controlled delivery of the transmitted energy 50 with the appropriate depth of focus, distribution, timing, and energy level to control the thermal coagulation zone 550 ("TCP") through the controlled operation of the control system 300 of the transducer 280 , For example, thermal freezing point) to achieve the desired therapeutic effect.
在一個實施例中，模組200可以耦合到手持棒狀器100。模組200可以發射和接收能量，例如超音能量。模組200可以電子耦合到手持棒狀器100，並且這種耦合可以包括與控制器300通信的介面。在一個實施例中，介面引導件235可以適於和/或配置成提供模組200和手持棒狀器100之間的電子通信。模組200可以包括各種探頭和/或換能器配置。例如，模組200可以適於和/或配置用於組合的雙模式成像/治療換能器、耦合或共同容納的成像/治療換能器、獨立的治療和成像探頭等。在一個實施例中，當模組200***或連接到手持棒狀器100時，控制器300自動檢測它並更新交互式圖形顯示器310。In one embodiment, the module 200 may be coupled to the handheld stick 100. The module 200 can transmit and receive energy, such as supersonic energy. The module 200 may be electronically coupled to the handheld stick 100, and such coupling may include an interface to communicate with the controller 300. In one embodiment, the interface guide 235 may be adapted and / or configured to provide electronic communication between the module 200 and the handheld stick 100. The module 200 may include various probe and / or transducer configurations. For example, the module 200 may be adapted and / or configured for combined dual-mode imaging / treatment transducers, coupled or co-contained imaging / treatment transducers, independent treatment and imaging probes, and the like. In one embodiment, when the module 200 is inserted or connected to the handheld stick 100, the controller 300 automatically detects it and updates the interactive graphic display 310.
在一些實施例中，存取密鑰320（例如，安全USB驅動，密鑰）連接（例如，可去除地）到系統20以允許系統20工作。在各種實施例中，存取密鑰被編程為客戶特定的，並且服務於多種功能，包括系統安全性、對治療指南和功能的國家/地區特定存取、軟件升級、支持日誌傳輸和/或信用轉讓和/或存儲。在各種實施例中，系統20具有網際網路和/或數據連接性。在實施例中，連接性提供了一種方法，通過該方法在系統20提供者和客戶之間傳輸數據。在各種實施例中，數據包括信用（credit）、軟件更新和支持日誌。根據使用者控制台如何連接到網際網路，將連接性劃分為不同的模型實施例。在一個實施例中，斷開模型連接性包括與網際網路斷開的控制台並且客戶不能進行網際網路存取。通過將存取密鑰（例如，USB驅動）發送給客戶來進行信用轉讓和軟件升級。在一個實施例中，半連接模型連接性包括與網際網路斷開的控制台，但是客戶能夠進行網際網路存取。使用客戶的個人計算機、智能電話或其他計算設備結合系統存取密鑰傳輸數據進行信用轉移、軟件升級和支持日誌傳輸。在一個實施例中，完全連接模型連接性包括使用wifi、蜂窩調變解調器、藍牙或其他協議無線連接到網際網路的控制台。信用轉讓、軟件升級和支持日誌傳輸直接在控制台和雲端之間進行。在各種實施例中，系統20連接到在線門戶，用於簡化庫存管理、按需求處理購買和商業分析見解以將客戶美容治療業務推向下一個級別。In some embodiments, the access key 320 (eg, secure USB drive, key) is connected (eg, removably) to the system 20 to allow the system 20 to work. In various embodiments, the access key is programmed to be customer-specific and serves multiple functions, including system security, country-specific access to treatment guidelines and functions, software upgrades, support for log transfer, and / or Credit transfer and / or storage. In various embodiments, the system 20 has Internet and / or data connectivity. In an embodiment, connectivity provides a method by which data is transferred between system 20 providers and customers. In various embodiments, the data includes credits, software updates, and support logs. According to how the user console is connected to the Internet, the connectivity is divided into different model embodiments. In one embodiment, disconnecting model connectivity includes a console that is disconnected from the Internet and clients cannot access the Internet. Credit transfers and software upgrades are sent by sending access keys (for example, USB drives) to customers. In one embodiment, the semi-connected model connectivity includes a console that is disconnected from the Internet, but customers are able to access the Internet. Use customer's personal computer, smart phone or other computing equipment in combination with system access key to transfer data for credit transfer, software upgrade and support log transmission. In one embodiment, the fully connected model connectivity includes using wifi, cellular modem, Bluetooth, or other protocols to wirelessly connect to the Internet console. Credit transfers, software upgrades, and support log transfers are directly between the console and the cloud. In various embodiments, the system 20 is connected to an online portal for simplifying inventory management, processing purchases on demand, and business analysis insights to take the customer's cosmetic treatment business to the next level.
在各種實施例中，用超音能量非侵入性地治療皮膚表面下方或甚至皮膚表面處的組織，例如表皮、真皮、下皮、筋膜和淺表肌肉腱膜系統（“SMAS”）和/或肌肉。組織還可以包括血管和/或神經。超音能量可以是聚焦的、未聚焦的或散焦的，並且施加到包含表皮、真皮、下皮、筋膜和SMAS中的至少一個的感興趣區域以實現治療效果。圖2是耦合到感興趣區域10的超音系統20的示意圖。在各種實施例中，感興趣區域10的組織層可以位於受試者身體的任何部分。在一個實施例中，組織層位於受試者的頭部和面部區域。感興趣區域10的組織的橫截面部分包括皮膚表面501、表皮層502、真皮層503、脂肪層505、淺表肌肉腱膜系統507（下文稱為“SMAS 507”）和肌肉層509。組織還可以包括下皮504，下皮可以包括真皮層503下方的任何組織。這些層的組合可以被總稱為皮下組織510。在圖2中也示出了位於表面501下方的治療區域525。在一個實施例中，表面501可以是受試者500的皮膚表面。儘管涉及在組織層處治療的實施例可以在本文中用作示例，但系統可以應用於身體中的任何組織。在各種實施例中，系統和/或方法可以用於面部、頸部、頭部、手臂、腿部或身體上或身體內的任何其他位置（包括體腔）的組織（包括但不限於肌肉、筋膜、SMAS、真皮、表皮、脂肪、脂肪細胞、脂肪團中的一種或組合，其可以稱為女性脂肪營養不良（例如，非凹陷型女性脂肪營養不良）、膠原、皮膚、血管。在各種實施例中，脂肪團（例如，非凹陷型女性脂肪營養不良）減少量達到2％、5％、10％、15％、20％、25％、30％、40％、50％、75％、80％、90％、95％及其中的任何範圍。In various embodiments, ultrasound energy is used to non-invasively treat tissues below or even at the surface of the skin, such as the epidermis, dermis, hypodermis, fascia, and superficial muscle aponeurosis system ("SMAS") and / or Or muscle. The tissue may also include blood vessels and / or nerves. The supersonic energy may be focused, unfocused, or defocused, and applied to a region of interest containing at least one of epidermis, dermis, hypodermis, fascia, and SMAS to achieve a therapeutic effect. FIG. 2 is a schematic diagram of the ultrasound system 20 coupled to the region of interest 10. In various embodiments, the tissue layer of the region of interest 10 may be located in any part of the subject's body. In one embodiment, the tissue layer is located in the subject's head and face area. The cross-sectional portion of the tissue of the region of interest 10 includes a skin surface 501, an epidermal layer 502, a dermal layer 503, a fat layer 505, a superficial muscle aponeurotic system 507 (hereinafter referred to as "SMAS 507"), and a muscle layer 509. The tissue may also include hypodermis 504, which may include any tissue under the dermis layer 503. The combination of these layers may be collectively referred to as subcutaneous tissue 510. The treatment area 525 below the surface 501 is also shown in FIG. 2. In one embodiment, the surface 501 may be the skin surface of the subject 500. Although the embodiments involving treatment at the tissue layer can be used as examples herein, the system can be applied to any tissue in the body. In various embodiments, the system and / or method may be used for tissues (including but not limited to muscles, tendons) on the face, neck, head, arms, legs, or any other location on or within the body (including body cavities) One or a combination of membranes, SMAS, dermis, epidermis, fat, adipocytes, cellulite, which can be called female lipodystrophy (eg, non-sag female lipodystrophy), collagen, skin, blood vessels. In various implementation In the example, the reduction in cellulite (eg, non-sag female fat malnutrition) reached 2%, 5%, 10%, 15%, 20%, 25%, 30%, 40%, 50%, 75%, 80 %, 90%, 95% and any range among them.
參考圖2中的圖示，超音系統20的實施例包括手持棒狀器100，模組200和控制器300。在一個實施例中，模組200包括換能器280。圖3示出了超音系統20的實施例，其具有適於和/或配置成在多個焦深278處治療組織的換能器280。在一個實施例中，焦深278是換能器280和用於治療的靶組織之間的距離。在一個實施例中，焦深278對於給定的換能器280是固定的。在一個實施例中，焦深278對於給定的換能器280是可變的。在一個實施例中，換能器280配置成在皮膚表面下方的多個深度（例如，1.5mm、3.0mm、4.5mm或其他深度）處同時治療。Referring to the illustration in FIG. 2, an embodiment of the ultrasound system 20 includes a handheld stick 100, a module 200 and a controller 300. In one embodiment, the module 200 includes a transducer 280. FIG. 3 shows an embodiment of an ultrasound system 20 having a transducer 280 adapted and / or configured to treat tissue at multiple depths of focus 278. In one embodiment, the depth of focus 278 is the distance between the transducer 280 and the target tissue used for treatment. In one embodiment, the depth of focus 278 is fixed for a given transducer 280. In one embodiment, the depth of focus 278 is variable for a given transducer 280. In one embodiment, the transducer 280 is configured to treat simultaneously at multiple depths (eg, 1.5 mm, 3.0 mm, 4.5 mm, or other depths) below the skin surface.
參考圖4中的圖示，模組200可以包括換能器280，所述換能器可以通過聲學透明構件230發射能量。在各種實施例中，深度可指代焦深278。在一個實施例中，換能器280可以具有偏移距離270，其是換能器280和聲學透明構件230的表面之間的距離。在一個實施例中，換能器280的焦深278是距換能器的固定距離。在一個實施例中，換能器280可以具有從換能器到聲學透明構件230的固定偏移距離270。在一個實施例中，聲學透明構件230適於和/或配置成位於模組200或超音系統20上的某位置處以接觸皮膚表面501。在各種實施例中，焦深278超過偏移距離270的量對應於位於皮膚表面501下方的組織深度279處的靶區域處的治療。在各種實施例中，當超音系統20放置成與皮膚表面501物理接觸時，組織深度279是聲學透明構件230和靶區域之間的距離，被測量為離接觸皮膚（有或沒有聲耦合凝膠、介質等）的手持棒狀器100或模組200表面的部分的距離和從該皮膚表面接觸點到靶區域的組織中的深度。在一個實施例中，焦深278可以對應於偏移距離270（到達與耦合介質和/或皮膚501接觸的聲學透明構件230的表面進行測量）加上到靶區域的皮膚表面501下方的組織深度279的總和。在各種實施例中，不使用聲學透明構件230。Referring to the illustration in FIG. 4, the module 200 may include a transducer 280, which may emit energy through the acoustic transparent member 230. In various embodiments, depth may refer to depth of focus 278. In one embodiment, the transducer 280 may have an offset distance 270, which is the distance between the transducer 280 and the surface of the acoustic transparent member 230. In one embodiment, the depth of focus 278 of the transducer 280 is a fixed distance from the transducer. In one embodiment, the transducer 280 may have a fixed offset distance 270 from the transducer to the acoustic transparent member 230. In one embodiment, the acoustic transparent member 230 is adapted and / or configured to be located at a location on the module 200 or the ultrasound system 20 to contact the skin surface 501. In various embodiments, the amount by which the depth of focus 278 exceeds the offset distance 270 corresponds to the treatment at the target area at the tissue depth 279 below the skin surface 501. In various embodiments, when the ultrasound system 20 is placed in physical contact with the skin surface 501, the tissue depth 279 is the distance between the acoustically transparent member 230 and the target area, which is measured as being away from contact with the skin (with or without acoustic coupling The distance between the portion of the surface of the handheld stick 100 or the module 200 and the depth from the skin surface contact point to the tissue in the target area. In one embodiment, the depth of focus 278 may correspond to the offset distance 270 (measured to the surface of the acoustically transparent member 230 in contact with the coupling medium and / or skin 501) plus the tissue depth below the skin surface 501 of the target area The sum of 279. In various embodiments, the acoustic transparent member 230 is not used.
耦合部件可以包括各種物質、材料和/或裝置，以促進換能器280或模組200與感興趣區域的耦合。例如，耦合部件可以包括聲耦合系統，其適於和/或配置用於超音能量和信號的聲耦合。具有可能的連接（例如歧管）的聲耦合系統可用於將聲音耦合到感興趣區域中，提供液體或流體填充的透鏡聚焦。耦合系統可以通過使用一種或多種耦合介質來促進這種耦合，所述耦合介質包括空氣、氣體、水、液體、流體、凝膠、固體、非凝膠和/或其任何組合，或允許信號在換能器280和感興趣區域之間傳輸的任何其他介質。在一個實施例中，在換能器內部提供一種或多種耦合介質。在一個實施例中，流體填充模組200在殼體內部包含一種或多種耦合介質。在一個實施例中，流體填充模組200在密封殼體內部包含一種或多種耦合介質，其與超音裝置的乾燥部分可分離。在各種實施例中，耦合介質用於在一個或多個裝置和組織之間傳輸超音能量，傳輸效率為100％、99％或以上、98％或以上、95％或以上、90％或以上、80％或以上、75％或以上、60％或以上、50％或以上、40％或以上、30％或以上、25％或以上、20％或以上、10％或以上和/或5％或以上。The coupling component may include various substances, materials, and / or devices to facilitate the coupling of the transducer 280 or the module 200 with the region of interest. For example, the coupling component may include an acoustic coupling system that is suitable and / or configured for acoustic coupling of supersonic energy and signals. Acoustic coupling systems with possible connections (such as manifolds) can be used to couple sound into the region of interest, providing liquid or fluid filled lens focusing. The coupling system may facilitate this coupling by using one or more coupling media, including air, gas, water, liquid, fluid, gel, solid, non-gel, and / or any combination thereof, or allowing the signal to Any other medium transmitted between the transducer 280 and the region of interest. In one embodiment, one or more coupling media are provided inside the transducer. In one embodiment, the fluid-filled module 200 contains one or more coupling media inside the housing. In one embodiment, the fluid-filled module 200 contains one or more coupling media inside the sealed housing, which is separable from the dry part of the ultrasound device. In various embodiments, the coupling medium is used to transmit ultrasonic energy between one or more devices and tissues with a transmission efficiency of 100%, 99% or more, 98% or more, 95% or more, 90% or more , 80% or more, 75% or more, 60% or more, 50% or more, 40% or more, 30% or more, 25% or more, 20% or more, 10% or more and / or 5% or above.
在各種實施例中，換能器280可以在任何合適的組織深度279處對感興趣區域進行成像和治療。在一個實施例中，換能器模組280可以提供在約1W或更小、在約1W至約100W之間和大於約100W（例如200W、300W、400W、500W）的範圍內的聲功率。在一個實施例中，換能器模組280可以提供約1MHz或更小、約1MHz至約10MHz之間（例如，3MHz、4MHz、4.5MHz、7MHz、10MHz）和大於約10MHz的頻率的聲功率。在一個實施例中，模組200具有焦深278，用於在皮膚表面501下方約4.5mm的組織深度279處進行治療。在一個實施例中，模組200具有焦深278，用於在皮膚表面501下方約3mm的組織深度279處進行治療。在一個實施例中，模組200具有焦深278，用於在皮膚表面501下方約1.5mm的組織深度279處進行治療。換能器280或模組200的一些非限制性實施例可以適於和/或配置用於在1.5mm、3mm、4.5mm、6mm、7mm、小於3mm、3mm至4.5mm之間、4.5mm至6mm之間、大於4.5mm、大於6mm等、以及0-3mm、0-4.5mm、0-6mm、0-25mm、0-100mm等範圍內的任何點的組織深度，以及其中的任何深度處遞送超音能量。在一個實施例中，超音系統20設置有兩個或更多個換能器模組280。例如，第一換能器模組可以在第一組織深度（例如，約4.5mm）處施加治療，第二換能器模組可以在第二組織深度（例如，約3mm）處施加治療，並且第三換能器模組可以在第三組織深度（例如，約1.5-2mm）處施加治療。在一個實施例中，至少一些或所有換能器模組可以適於和/或配置成在大致相同的深度處施加治療。In various embodiments, the transducer 280 may image and treat the region of interest at any suitable tissue depth 279. In one embodiment, the transducer module 280 may provide acoustic power in the range of about 1 W or less, between about 1 W to about 100 W, and greater than about 100 W (eg, 200 W, 300 W, 400 W, 500 W). In one embodiment, the transducer module 280 may provide acoustic power of about 1 MHz or less, between about 1 MHz and about 10 MHz (eg, 3 MHz, 4 MHz, 4.5 MHz, 7 MHz, 10 MHz) and frequencies greater than about 10 MHz . In one embodiment, the module 200 has a depth of focus 278 for treatment at a tissue depth 279 of about 4.5 mm below the skin surface 501. In one embodiment, the module 200 has a depth of focus 278 for treatment at a tissue depth 279 of about 3 mm below the skin surface 501. In one embodiment, the module 200 has a depth of focus 278 for treatment at a tissue depth 279 of about 1.5 mm below the skin surface 501. Some non-limiting embodiments of the transducer 280 or the module 200 may be adapted and / or configured to be between 1.5mm, 3mm, 4.5mm, 6mm, 7mm, less than 3mm, 3mm to 4.5mm, 4.5mm to Depth of tissue between 6mm, greater than 4.5mm, greater than 6mm, etc., and any point within the range of 0-3mm, 0-4.5mm, 0-6mm, 0-25mm, 0-100mm, and delivery at any depth therein Supersonic energy. In one embodiment, the ultrasound system 20 is provided with two or more transducer modules 280. For example, the first transducer module may apply treatment at a first tissue depth (eg, about 4.5 mm), and the second transducer module may apply treatment at a second tissue depth (eg, about 3 mm), and The third transducer module may apply treatment at a third tissue depth (eg, about 1.5-2 mm). In one embodiment, at least some or all of the transducer modules may be adapted and / or configured to apply therapy at approximately the same depth.
在各種實施例中，改變用於超音程序的焦點位置（例如，例如具有組織深度279）的數量可能是有利的，原因是它允許在不同組織深度處治療患者，即使換能器270的焦深278是固定的。這可以提供協同結果並最大化單個治療療程的臨床結果。例如，在單個表面區域下方的多個深度處的治療允許組織治療的更大總體積，這導致增強的膠原形成和收緊。另外，在不同深度處的治療影響不同類型的組織，由此產生不同的臨床效果，這些效果一起提供增強的整體美容效果。例如，表面治療可以降低皺紋的可見度，並且更深的治療可以誘導形成更多的膠原生長。類似地，在相同或不同深度的各種位置處的治療可以改善治療。In various embodiments, it may be advantageous to change the number of focal positions (eg, with tissue depth 279) for ultrasound programs because it allows the treatment of patients at different tissue depths, even if the focus of transducer 270 Deep 278 is fixed. This can provide synergistic results and maximize the clinical outcome of a single course of treatment. For example, treatment at multiple depths below a single surface area allows a greater total volume of tissue treatment, which results in enhanced collagen formation and tightening. In addition, treatments at different depths affect different types of tissues, thereby producing different clinical effects, which together provide an enhanced overall cosmetic effect. For example, surface treatments can reduce the visibility of wrinkles, and deeper treatments can induce the formation of more collagen growth. Similarly, treatment at various locations at the same or different depths can improve treatment.
儘管在一個療程中在不同位置處治療受試者可能在一些實施例中是有利的，但是在其他實施例中按時間的順序治療可能是有益的。例如，可以在相同表面區域下治療受試者，在第一時間以第一深度、在第二時間以第二深度等等。在各種實施例中，時間可以是奈秒、微秒、毫秒、秒、分鐘、小時、天、周、月或其他時間段的量級。通過第一治療產生的新膠原可能對隨後的治療更敏感，這對於一些適應症可能是期望的。替代地，在單個療程中在相同表面區域下進行多深度治療可能是有利的，原因是在一個深度處的治療可以協同地增強或補充另一深度處的治療（由於例如增強的血流、生長因子的刺激、激素刺激等）。在若干實施例中，不同的換能器模組提供不同深度處的治療。在一個實施例中，可以針對變化的深度調節或控制單個換能器模組。最小化將選擇錯誤深度的風險的安全特徵可以與單個模組系統結合使用。Although it may be advantageous in some embodiments to treat a subject at different locations during a course of treatment, in other embodiments it may be beneficial to treat in chronological order. For example, a subject can be treated under the same surface area, at a first depth at a first time, at a second depth at a second time, and so on. In various embodiments, time may be on the order of nanoseconds, microseconds, milliseconds, seconds, minutes, hours, days, weeks, months, or other time periods. The new collagen produced by the first treatment may be more sensitive to subsequent treatments, which may be desirable for some indications. Alternatively, it may be advantageous to perform multiple depth treatments under the same surface area in a single course of treatment because treatment at one depth can synergistically enhance or supplement treatment at another depth (due to, for example, enhanced blood Factor stimulation, hormone stimulation, etc.). In several embodiments, different transducer modules provide treatment at different depths. In one embodiment, a single transducer module can be adjusted or controlled for varying depths. Safety features that minimize the risk of choosing the wrong depth can be used in conjunction with a single module system.
在若干實施例中，提供了一種治療下面部和頸部區域（例如，頦下區域）的方法。在若干實施例中，提供了治療（例如，軟化）頦唇褶皺的方法。在其他實施例中，提供了治療眼部區域（例如，顴骨袋、治療眶下鬆弛）的方法。通過在可變深度處治療，若干實施例將實現上眼瞼鬆弛度改善和眶周線和紋理改善。通過在單個療程中在不同位置處進行治療，可以實現最佳臨床效果（例如，軟化、收緊）。在若干實施例中，本文描述的治療方法是非侵入性美容程序。在一些實施例中，方法可以與侵入性程序結合使用，例如手術整容或吸脂，其中期望皮膚收緊。在各種實施例中，方法可以應用於身體的任何部位。In several embodiments, a method of treating an inferior and neck area (eg, submental area) is provided. In several embodiments, a method of treating (eg, softening) the chin fold is provided. In other embodiments, a method of treating an eye area (eg, zygomatic pouch, treating suborbital laxity) is provided. By treating at variable depths, several embodiments will achieve improved upper eyelid laxity and improved periorbital lines and texture. By treating at different locations in a single course of treatment, the best clinical results (eg, softening, tightening) can be achieved. In several embodiments, the treatment methods described herein are non-invasive cosmetic procedures. In some embodiments, the method may be used in conjunction with an invasive procedure, such as surgical facelift or liposuction, where skin tightening is desired. In various embodiments, the method can be applied to any part of the body.
在一個實施例中，換能器模組200允許在皮膚表面處或下方的固定深度處的治療序列。在一個實施例中，換能器模組允許在真皮層下方的一個，兩個或更多個可變或固定深度處的治療序列。在若干實施例中，換能器模組包括移動機構，所述移動機構適於和/或配置成在固定焦深處在單獨的熱損傷（下文中稱為“熱凝固點”或“TCP”）的序列中引導超音治療。在一個實施例中，單獨的TCP的序列具有在約0.01mm至約25mm的範圍（例如，1mm、1.5mm、2mm、2.5mm、3mm、5mm、10mm、20mm及其中的任何數值範圍）內的治療間隔，間隔的抖動（dithering）改變為1-50％（例如，1％、5％、10％、15％、20％、25％、30％、35％、40％、45％、50％及其中的任何範圍）。例如，間隔可以為1.1mm或以下、1.5mm或以上、在約1.1mm至約1.5mm之間等。在一個實施例中，單獨的TCP是離散的。在一個實施例中，單獨的TCP是重疊的。在一個實施例中，移動機構適於和/或配置成被編程以提供單獨的TCP之間的可變間隔。在一個實施例中，抖動可以適於和/或配置成提供單獨的TCP之間的可變間隔。在若干實施例中，換能器模組包括移動機構，所述移動機構適於和/或配置成在序列中引導超音治療，使得TCP在由治療距離分離的線性或大致線性的序列中形成。例如，換能器模組可以適於和/或配置成沿著第一線性序列和與第一線性序列分離治療距離的第二線性序列形成TCP。在一個實施例中，單獨的TCP的相鄰線性序列之間的治療距離在約0.01mm至約25mm的範圍內。在一個實施例中，單獨的TCP的相鄰線性序列之間的治療距離為約0.01mm至約50mm。例如，治療距離可以為2mm或以下、3mm或以上、在約2mm至約3mm之間等。在若干實施例中，換能器模組可以包括一個或多個移動機構400，其適於和/或配置成在序列中引導超音治療，使得TCP在與其他線性序列分離治療距離的單獨的熱損傷的線性或大致線性的序列中形成。在一個實施例中，在第一方向290上施加治療（例如，推）。在一個實施例中，與第一方向290相反地施加治療（例如，拉）。在一個實施例中，在第一方向290和與第一方向相反的方向上施加治療（例如，推拉）。在一個實施例中，分離線性或大致線性的TCP序列的治療距離相同或基本相同。在一個實施例中，對於各種相鄰的線性TCP序列對，分離線性或大致線性的TCP序列的治療距離是不同的或基本不同的。In one embodiment, the transducer module 200 allows a treatment sequence at a fixed depth at or below the skin surface. In one embodiment, the transducer module allows one, two or more treatment sequences at variable or fixed depths below the dermis layer. In several embodiments, the transducer module includes a movement mechanism that is adapted and / or configured to be at a fixed depth of focus at a single thermal damage (hereinafter referred to as "thermal freezing point" or "TCP") Guided ultrasound therapy in the sequence. In one embodiment, the sequence of individual TCPs has a value in the range of about 0.01 mm to about 25 mm (eg, 1 mm, 1.5 mm, 2 mm, 2.5 mm, 3 mm, 5 mm, 10 mm, 20 mm, and any value range thereof) Treatment interval, the dithering of the interval is changed to 1-50% (for example, 1%, 5%, 10%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, 50%) And any range in it). For example, the interval may be 1.1 mm or less, 1.5 mm or more, between about 1.1 mm to about 1.5 mm, and so on. In one embodiment, the individual TCPs are discrete. In one embodiment, the individual TCPs are overlapping. In one embodiment, the movement mechanism is adapted and / or configured to be programmed to provide variable intervals between individual TCPs. In one embodiment, the jitter may be adapted and / or configured to provide variable spacing between individual TCPs. In several embodiments, the transducer module includes a movement mechanism adapted and / or configured to guide ultrasound therapy in a sequence such that TCP is formed in a linear or substantially linear sequence separated by treatment distance . For example, the transducer module may be adapted and / or configured to form TCP along a first linear sequence and a second linear sequence separated from the first linear sequence by a treatment distance. In one embodiment, the treatment distance between adjacent linear sequences of individual TCPs is in the range of about 0.01 mm to about 25 mm. In one embodiment, the treatment distance between adjacent linear sequences of individual TCPs is from about 0.01 mm to about 50 mm. For example, the treatment distance may be 2 mm or less, 3 mm or more, between about 2 mm to about 3 mm, and so on. In several embodiments, the transducer module may include one or more movement mechanisms 400 that are adapted and / or configured to guide ultrasound therapy in a sequence such that TCP separates the treatment distance from other linear sequences in a separate Thermal damage is formed in a linear or substantially linear sequence. In one embodiment, treatment (eg, push) is applied in the first direction 290. In one embodiment, the treatment (eg, pulling) is applied against the first direction 290. In one embodiment, the treatment (eg, push-pull) is applied in the first direction 290 and the direction opposite to the first direction. In one embodiment, the treatment distance separating the linear or substantially linear TCP sequences is the same or substantially the same. In one embodiment, for various adjacent linear TCP sequence pairs, the treatment distance separating the linear or substantially linear TCP sequences is different or substantially different.
在一個實施例中，提供第一和第二可去除換能器模組。在一個實施例中，第一和第二換能器模組中的每一個適於和/或配置用於超音成像和超音治療。在一個實施例中，換能器模組適於和/或配置僅用於治療。在一個實施例中，成像換能器可以附接到探頭的手柄或手持棒狀器。第一和第二換能器模組適於和/或配置用於可互換地耦合到手持棒狀器。第一換能器模組適於和/或配置成將超音治療施加到第一組織層，而第二換能器模組適於和/或配置成將超音治療施加到第二組織層。第二層組織處於與第一層組織不同的深度。In one embodiment, first and second removable transducer modules are provided. In one embodiment, each of the first and second transducer modules is suitable and / or configured for ultrasound imaging and ultrasound therapy. In one embodiment, the transducer module is adapted and / or configured for treatment only. In one embodiment, the imaging transducer may be attached to the handle of the probe or a handheld stick. The first and second transducer modules are adapted and / or configured to be interchangeably coupled to the handheld stick. The first transducer module is adapted and / or configured to apply ultrasound therapy to the first tissue layer, and the second transducer module is adapted and / or configured to apply ultrasound therapy to the second tissue layer . The second layer of tissue is at a different depth than the first layer of tissue.
如圖3中所示，在各種實施例中，模組200通過控制系統300的受控操作提供以合適的焦深278、分佈、定時和能量水平遞送發射的能量50以實現受控熱損傷的期望治療效果以治療表皮層502、真皮層503、脂肪層505、SMAS層507、肌肉層509和/或下皮504中的至少一個。圖3示出了對應於用於治療肌肉的深度的深度的一個實施例。在各種實施例中，該深度可以對應於任何組織、組織層、皮膚、表皮、真皮、下皮、脂肪、SMAS、肌肉、血管、神經或其他組織。在操作期間，模組200和/或換能器280也可以沿著表面501機械地和/或電子地掃描以治療延伸區域。在將超音能量50遞送至表皮層502、真皮層503、下皮504、脂肪層505、SMAS層507和/或肌肉層509中的至少一個之前，期間和之後，可以提供治療區域和周圍結構的監測以規劃和評估結果和/或經由圖形介面310向控制器300和使用者提供反饋。As shown in FIG. 3, in various embodiments, the module 200 provides controlled delivery of the emitted energy 50 at a suitable depth of focus 278, distribution, timing, and energy level through controlled operation of the control system 300 to achieve controlled thermal damage. A therapeutic effect is desired to treat at least one of epidermal layer 502, dermis layer 503, fat layer 505, SMAS layer 507, muscle layer 509, and / or hypodermis 504. Figure 3 shows one embodiment of a depth corresponding to the depth used to treat muscles. In various embodiments, the depth may correspond to any tissue, tissue layer, skin, epidermis, dermis, hypodermis, fat, SMAS, muscle, blood vessel, nerve, or other tissue. During operation, the module 200 and / or the transducer 280 may also be scanned mechanically and / or electronically along the surface 501 to treat the extended area. Before, during and after the delivery of ultrasound energy 50 to at least one of the epidermal layer 502, the dermal layer 503, the hypodermis 504, the fat layer 505, the SMAS layer 507, and / or the muscle layer 509, a treatment area and surrounding structures can be provided Monitoring to plan and evaluate the results and / or provide feedback to the controller 300 and the user via the graphical interface 310.
在一個實施例中，超音系統20生成引導並聚焦在表面501下方的超音能量。該受控和聚焦的超音能量50產生熱凝固點或區域（TCP）550。在一個實施例中，超音能量50在皮下組織510中產生空隙。在各種實施例中，發射的能量50靶向表面501下方的組織，其切割、消融、凝固、微消融、操縱和/或引起指定焦深278處的表面501下方的組織部分10中的TCP 550。在一個實施例中，在治療序列期間，換能器280以指定間隔295在標記為290的箭頭所示的方向上移動以產生一系列治療區域254，每個治療區域接收發射的能量50以產生一個或多個TCP 550。在一個實施例中，標記為291的箭頭示出與箭頭290正交或平行的軸線或方向，並且TCP 550的間隔示出TCP可以與換能器280的運動方向正交或平行地間隔開。在一些實施例中，間隔的TCP的取向可以設置為與箭頭290成0-180度的任何角。在一些實施例中，間隔的TCP的取向可以基於換能器280上的極化區域的取向以0-180度的任何角設置。In one embodiment, the ultrasound system 20 generates ultrasound energy directed and focused below the surface 501. This controlled and focused supersonic energy 50 produces a thermal freezing point or area (TCP) 550. In one embodiment, the supersonic energy 50 creates voids in the subcutaneous tissue 510. In various embodiments, the emitted energy 50 targets the tissue below the surface 501, which cuts, ablate, coagulates, micro-ablates, manipulates, and / or causes TCP 550 in the tissue portion 10 below the surface 501 at a specified depth of focus 278 . In one embodiment, during the treatment sequence, the transducer 280 moves at a specified interval 295 in the direction indicated by the arrow labeled 290 to produce a series of treatment areas 254, each of which receives the transmitted energy 50 to produce One or more TCP 550. In one embodiment, the arrow labeled 291 shows an axis or direction orthogonal or parallel to arrow 290, and the spacing of TCP 550 shows that TCP can be spaced orthogonally or parallel to the direction of motion of transducer 280. In some embodiments, the orientation of the spaced TCP can be set to any angle between 0 and 180 degrees from arrow 290. In some embodiments, the orientation of the spaced TCP may be set at any angle of 0-180 degrees based on the orientation of the polarization region on the transducer 280.
在各種實施例中，換能器模組可以包括一個或多個換能元件。換能元件可以包括壓電活性材料，如鋯鈦酸鉛（PZT），或任何其他壓電活性材料，如壓電陶瓷、晶體、塑料和/或複合材料，以及鈮酸鋰、鈦酸鉛、鈦酸鋇和/或偏鈮酸鉛。在各種實施例中，作為壓電活性材料的附加或替代，換能器模組可以包括適於和/或配置用於生成輻射和/或聲能的任何其他材料。在各種實施例中，換能器模組可適於和/或配置成以不同頻率和治療深度操作。換能器性質可以由外徑（“OD”）和焦距（FL
）限定。在一個實施例中，換能器可以適於和/或配置成具有OD = 19mm和FL
= 15mm。在其他實施例中，可以使用其他合適的OD和FL
值，例如OD小於約19mm、大於約19mm等、FL
小於約15mm、大於約15mm等。換能器模組可以適於和/或配置成在不同的靶組織深度處施加超音能量。如上所述，在若干實施例中，換能器模組包括移動機構，所述移動機構適於和/或配置成在單獨的TCP的線性或大致線性的序列中引導超音治療，單獨的TCP之間具有治療間隔。例如，治療間隔可以為約1.1mm、1.5mm等。在若干實施例中，換能器模組還可以包括移動機構，所述移動機構適於和/或配置成在序列中引導超音治療，使得TCP在由治療間隔分離的線性或大致線性的序列中形成。例如，換能器模組可以適於和/或配置成沿著第一線性序列和與第一線性序列分離約2mm至3mm之間的治療間隔的第二線性序列形成TCP。在一個實施例中，使用者可以在治療區域的表面上手動移動換能器模組，使得產生相鄰的TCP線性序列。在一個實施例中，移動機構可以自動地使換能器模組在治療區域的表面上移動，使得產生相鄰的TCP線性序列。
孔徑空間頻率分析和傅立葉變換 In various embodiments, the transducer module may include one or more transducing elements. Transducer elements may include piezoelectric active materials, such as lead zirconate titanate (PZT), or any other piezoelectric active materials, such as piezoelectric ceramics, crystals, plastics, and / or composite materials, as well as lithium niobate, lead titanate, Barium titanate and / or lead niobate. In various embodiments, as an addition or alternative to piezoelectrically active materials, the transducer module may include any other material suitable and / or configured for generating radiation and / or acoustic energy. In various embodiments, the transducer module may be adapted and / or configured to operate at different frequencies and treatment depths. The transducer properties can be defined by the outer diameter ("OD") and the focal length ( FL ). In one embodiment, the transducer may be adapted and / or configured to have OD = 19mm and FL = 15mm. In other embodiments, other suitable OD and FL values may be used, such as OD less than about 19 mm, greater than about 19 mm, etc., FL less than about 15 mm, greater than about 15 mm, etc. The transducer module may be adapted and / or configured to apply ultrasound energy at different target tissue depths. As mentioned above, in several embodiments, the transducer module includes a movement mechanism adapted and / or configured to guide ultrasound therapy in a linear or substantially linear sequence of separate TCPs, separate TCPs There is a treatment interval between. For example, the treatment interval may be about 1.1 mm, 1.5 mm, etc. In several embodiments, the transducer module may also include a movement mechanism adapted and / or configured to guide ultrasound therapy in a sequence such that TCP is in a linear or substantially linear sequence separated by treatment intervals中 Formation. For example, the transducer module may be adapted and / or configured to form TCP along a first linear sequence and a second linear sequence separated from the first linear sequence by a treatment interval between about 2 mm and 3 mm. In one embodiment, the user can manually move the transducer module on the surface of the treatment area so that adjacent linear sequences of TCP are generated. In one embodiment, the moving mechanism can automatically move the transducer module on the surface of the treatment area so that adjacent linear sequences of TCP are generated.
Aperture spatial frequency analysis and Fourier transform
在各種實施例中，基於傅立葉分析和傅立葉光學的空間頻率分析技術可以用於提高治療處理的效率。當具有脈衝響應h(t)
的系統由刺激x(t)
激勵時，輸入x(t)
和輸出y(t)
之間的關係由如下的卷積函數關聯：
（1）In various embodiments, the spatial frequency analysis technique based on Fourier analysis and Fourier optics can be used to improve the efficiency of the treatment process. When the system with impulse response h (t) is excited by stimulus x (t) , the relationship between input x (t) and output y (t) is related by the following convolution function:
(1)
在各種實施例中，可以應用傅立葉變換來計算方程式（1）的卷積。連續一維傅立葉變換可以定義為：
（2）In various embodiments, the Fourier transform can be applied to calculate the convolution of equation (1). The continuous one-dimensional Fourier transform can be defined as:
(2)
這裡f是頻率，t是時間。可以表明時域中的卷積等效於頻域中的乘法：
（3）Here f is frequency and t is time. It can be shown that convolution in the time domain is equivalent to multiplication in the frequency domain:
(3)
在各種實施例中，夫琅和費（Fraunhofer）近似可以用於導出換能器開口或孔徑與所得超音波束響應之間的關係。夫琅和費近似的推導在Joseph Goodman，Introduction to Fourier Optics （第三版，2004）中描述，其全部內容通過引用併入本文。根據夫琅和費近似，由複合孔徑產生的遠場複合幅度模式等於孔徑幅度和相位的二維傅立葉變換。在若干實施例中，光學中的該關係可以擴展到超音，原因是線性波動方程可以用於表示光傳播和聲音傳播。在光學和/或超音的情況下，二維傅立葉變換可以確定換能器的焦點處的聲波壓力幅度分佈。In various embodiments, the Fraunhofer approximation can be used to derive the relationship between the transducer opening or aperture and the resulting ultrasound beam response. Fraunhofer's approximate derivation is described in Joseph Goodman, Introduction to Fourier Optics (Third Edition, 2004), the entire contents of which are incorporated by reference. According to Fraunhofer approximation, the far-field composite amplitude mode generated by the composite aperture is equal to the two-dimensional Fourier transform of the aperture amplitude and phase. In several embodiments, this relationship in optics can be extended to supersonic waves because the linear wave equation can be used to represent light propagation and sound propagation. In the case of optics and / or ultrasound, the two-dimensional Fourier transform can determine the acoustic wave pressure amplitude distribution at the focal point of the transducer.
對於聚焦系統，表示深度的變量z
可以用表示焦距的zf
代替。
（4a）
（4b）For focusing systems, the variable z representing depth can be replaced with z f representing focal length.
(4a)
(4b)
在各種實施例中，傅立葉光學和傅立葉變換恆等式（其中一些在下面的表1中列出）可以用於超音換能器以便確定對應於換能器設計的強度分佈。例如，矩形rect(ax)
的傅立葉變換是sinc函數。作為另一示例，均勻幅度的二維圓的傅立葉變換是一階貝塞爾函數，其可以表示為J1
。
在若干實施例中，超音換能器可以具有合適尺寸和焦距的矩形孔徑。在若干實施例中，超音換能器可以具有合適尺寸和焦距的圓形孔徑。在一個實施例中，換能器可以具有圓形孔徑，其外半徑約為9.5mm，內徑約為2mm，焦距約為15mm。圓形換能器的孔徑可以描述為：
（5a）
（5b）In several embodiments, the ultrasonic transducer may have a rectangular aperture of suitable size and focal length. In several embodiments, the ultrasonic transducer may have a circular aperture of suitable size and focal length. In one embodiment, the transducer may have a circular aperture with an outer radius of about 9.5mm, an inner diameter of about 2mm, and a focal length of about 15mm. The aperture of a circular transducer can be described as:
(5a)
(5b)
例如，在一個實施例中，變量“a”可以約為9.5mm，並且方程式（5a）中的變量“b”可以約為2mm。將傅立葉變換應用於方程式（5a）可以提供焦點處的聲波壓力分佈的估計。
（6）For example, in one embodiment, the variable "a" may be approximately 9.5 mm, and the variable "b" in equation (5a) may be approximately 2 mm. Applying the Fourier transform to equation (5a) can provide an estimate of the sound pressure distribution at the focal point.
(6)
其中和與方程式（4a）和（4b）的fx 和fy 相同。方程式（6）表明具有圓形孔徑的換能器的聲波壓力分佈是一階貝塞爾函數。在一個實施例中，絕大部分能量集中在焦點處（例如，距離孔徑15mm）。主超音波束的寬度和遠離主波束的能量分佈可以表示為操作頻率的函數，如方程式（4a）和（4b）中所示。among them with It is the same as f x and f y in equations (4a) and (4b). Equation (6) shows that the acoustic wave pressure distribution of a transducer with a circular aperture is a first-order Bessel function. In one embodiment, most of the energy is concentrated at the focal point (eg, 15 mm from the aperture). The width of the main ultrasound beam and the energy distribution away from the main beam can be expressed as a function of the operating frequency, as shown in equations (4a) and (4b).
在各種實施例中，如果通過正確的函數調製（例如，相乘）孔徑，則可以在焦點處產生兩個相同或幾乎相同的波束。在一個實施例中，餘弦函數可以如下應用於圓形孔徑：
（7）In various embodiments, if the aperture is modulated (eg, multiplied) by the correct function, two identical or nearly identical beams can be generated at the focal point. In one embodiment, the cosine function can be applied to a circular aperture as follows:
(7)
在方程（7）的調製孔徑的焦點處的能量分佈或波束響應是孔徑的兩個函數的傅立葉變換的卷積：
（8）The energy distribution or beam response at the focal point of the modulation aperture of equation (7) is the convolution of the Fourier transform of the two functions of the aperture:
(8)
方程（8）可以簡化為應用狄拉克δ函數的傅立葉變換恆等式（例如，表2中的恆等式2）的兩個獨立函數的總和：
（9）Equation (8) can be simplified to the sum of two independent functions applying the Fourier transform identity of the Dirac delta function (for example, identity 2 in Table 2):
(9)
方程（9）表明，與原始的非調製波束相比，出現在焦點處的兩個波束在空間上偏移±。在若干實施例中，可以使用一個或多個其他調製函數（例如正弦函數）來實現期望的波束響應。在若干實施例中，可以調製孔徑，使得產生兩個以上焦點。例如，可以產生三個、四個、五個等焦點。在若干實施例中，可以調製孔徑，使得焦點依序地或大致依序地而不是同時地產生。Equation (9) shows that the two beams appearing at the focal point are spatially offset from the original unmodulated beam ± . In several embodiments, one or more other modulation functions (eg, sinusoidal functions) may be used to achieve the desired beam response. In several embodiments, the aperture can be modulated so that more than two focal points are produced. For example, three, four, five, etc. focal points can be generated. In several embodiments, the aperture may be modulated so that the focal points are generated sequentially or substantially sequentially rather than simultaneously.
在若干實施例中，治療換能器模組包括移動機構，所述移動機構配置成在單獨的TCP的線性或大致線性序列中引導超音治療，其中單獨的TCP之間具有治療間隔。例如，治療間隔可以為約1.1mm、1.5mm等。在若干實施例中，換能器模組還可以包括移動機構，所述移動機構配置成在序列中引導超音治療，使得TCP在由治療間隔分離的線性或大致線性序列中形成。例如，換能器模組可以配置成沿著第一線性序列和與第一線性序列分離約2mm至3mm之間的治療間隔的第二線性序列形成TCP。根據方程式（9），如果通過期望空間頻率的餘弦和/或正弦函數調製孔徑，則可以在焦點處（或在焦點之前）實現超音波束的同時或大致同時***。在一個實施例中，由約1.1mm治療間隔分離的兩個同時或幾乎同時聚焦波束可以在線性或大致線性序列中產生。在7MHz的超音頻率下，水中超音波的波長λ約為0.220 mm。因此，焦點處的空間頻率和表示為：
（10a）
（10b）In several embodiments, the treatment transducer module includes a movement mechanism configured to guide ultrasound therapy in a linear or substantially linear sequence of individual TCPs, with treatment intervals between individual TCPs. For example, the treatment interval may be about 1.1 mm, 1.5 mm, etc. In several embodiments, the transducer module may also include a movement mechanism configured to guide ultrasound therapy in a sequence such that TCP is formed in a linear or substantially linear sequence separated by treatment intervals. For example, the transducer module may be configured to form TCP along a first linear sequence and a second linear sequence separated from the first linear sequence by a treatment interval between about 2 mm and 3 mm. According to equation (9), if the aperture is modulated by the cosine and / or sine function of the desired spatial frequency, the simultaneous or approximately simultaneous splitting of the ultrasound beam can be achieved at the focal point (or before the focal point). In one embodiment, two simultaneous or nearly simultaneous focusing beams separated by a treatment interval of about 1.1 mm can be generated in a linear or substantially linear sequence. At a supersonic frequency of 7 MHz, the wavelength λ of supersonic waves in water is about 0.220 mm. Therefore, the spatial frequency at the focal point with Expressed as:
(10a)
(10b)
為了將兩個焦點分開約1.1mm，然後如下計算用於調製孔徑的空間頻率。使用表2中的恆等式3和4，正弦或餘弦函數的傅立葉變換是狄拉克δ函數，其參數為：
（11a）In order to separate the two focal points by about 1.1 mm, the spatial frequency for the modulation aperture is then calculated as follows. Using identities 3 and 4 in Table 2, the Fourier transform of the sine or cosine function is the Dirac delta function, and its parameters are:
(11a)
在一個實施例中，當參數為0時，方程式（11a）可以求解kx
：
（11b）In one embodiment, when the parameter is 0, equation (11a) can solve for k x :
(11b)
此外，xo
可以用分離距離（例如，1.1mm）的一半代替：
（11c）In addition, x o can be replaced by half of the separation distance (for example, 1.1 mm):
(11c)
在若干實施例中，具有在各種操作頻率下發射超音能量的圓形孔徑的換能器可以通過表2中列出的空間頻率的正弦和/或餘弦函數進行調製。換能器的調製孔徑可以用具有不同分離距離的兩個焦點產生同時或大致同時的***波束，如表2中所示。在一個實施例中，換能器可以具有約19mm的OD和約15mm的焦距。
如表2中所示，在若干實施例中，對於給定焦點分離距離，孔徑調製函數的空間頻率隨著超音操作頻率的增加而增加。另外，空間頻率隨著期望焦點分離距離的增加而增加。As shown in Table 2, in several embodiments, for a given focal separation distance, the spatial frequency of the aperture modulation function increases as the ultrasound operating frequency increases. In addition, the spatial frequency increases as the desired focal separation distance increases.
在一個實施例中，較高的空間頻率可以導致孔徑中的幅度轉變更快地發生。由於換能器處理限制，孔徑中的快速幅度變化可能使孔徑效率降低，原因是孔徑的不同部分產生的聲壓量可能存在差異。在一個實施例中，使用空間頻率同時或幾乎同時***波束可以減小每個波束的總焦點增益。如方程式（9）中所示，與未調製的波束相比，每個波束焦點處的場壓降低為二分之一。在一個實施例中，可以增加來自孔徑的聲壓或超音強度以在焦平面處獲得類似或基本相似的強度。然而，在一個實施例中，增加孔徑處的壓力可能不受系統和/或換能器處理限制的限制。在一個實施例中，孔徑處的壓力的增加可以增加近場中的總強度，這可以增加過度加熱位於焦點之前的治療區域組織的可能性。在一個實施例中，可以通過使用較低的超音治療頻率來限制或消除額外加熱焦點前組織的可能性。In one embodiment, a higher spatial frequency may cause the amplitude transition in the aperture to occur faster. Due to transducer processing limitations, rapid amplitude changes in the aperture may reduce the efficiency of the aperture because the amount of sound pressure produced by different parts of the aperture may be different. In one embodiment, the use of spatial frequencies to split the beams simultaneously or nearly simultaneously can reduce the total focus gain of each beam. As shown in equation (9), the field pressure at the focal point of each beam is reduced by half compared to the unmodulated beam. In one embodiment, the sound pressure or supersonic intensity from the aperture can be increased to obtain a similar or substantially similar intensity at the focal plane. However, in one embodiment, increasing the pressure at the aperture may not be limited by system and / or transducer processing limitations. In one embodiment, an increase in pressure at the aperture can increase the total intensity in the near field, which can increase the likelihood of overheating the tissue of the treatment area located before the focal point. In one embodiment, the possibility of additional heating of the pre-focus tissue can be limited or eliminated by using a lower frequency of ultrasound treatment.
在一個實施例中，應用如方程式（7）中所示的孔徑調製函數導致在焦點處的兩個同時或大致同時的超音波束。在各種實施例中，超音波束可以被***多次，例如三次、四次、五次等，使得產生多個同時或幾乎同時的波束。在一個實施例中，可以通過將孔徑調製或乘以兩個獨立的空間頻率來生成沿一個維度的四個等間隔的波束：
（12a）
（12b）In one embodiment, applying the aperture modulation function as shown in equation (7) results in two simultaneous or approximately simultaneous supersonic beams at the focal point. In various embodiments, the ultrasound beam may be split multiple times, such as three times, four times, five times, etc., so that multiple simultaneous or nearly simultaneous beams are generated. In one embodiment, four equally spaced beams along one dimension can be generated by modulating or multiplying the aperture by two independent spatial frequencies:
(12a)
(12b)
如方程式（12b）中所示，可以在沿x軸的四個不同位置處產生焦點處的未調製波束。在一個實施例中，可以將常數或DC項C1添加到幅度調製函數以維持在原始焦點位置處的能量放置：
（13a）
（13b）As shown in equation (12b), an unmodulated beam at the focal point can be generated at four different positions along the x-axis. In one embodiment, a constant or DC term C1 can be added to the amplitude modulation function to maintain the energy placement at the original focal position:
(13a)
(13b)
在一個實施例中，由於系統、材料和/或組織限制，方程式（12）和（13）的孔徑調製，由此波束可以同時或幾乎同時放置在多個位置，可能具有有限的適用性。在一個實施例中，由於加熱位於焦點之前的治療區域組織的可能性，可以調節（例如降低）超音治療的頻率，以便限制和/或消除這種可能性。在一個實施例中，可以在焦點處應用非線性技術，以便限制和/或消除加熱焦點前組織的可能性。在一個實施例中，可以增加來自孔徑的聲壓或超音強度以在焦平面處獲得相似或基本相似的強度。In one embodiment, due to system, material, and / or tissue limitations, the aperture modulation of equations (12) and (13), whereby the beams can be placed at multiple locations simultaneously or nearly simultaneously, may have limited applicability. In one embodiment, due to the possibility of heating tissue in the treatment area located before the focal point, the frequency of ultrasound treatment may be adjusted (eg, reduced) in order to limit and / or eliminate this possibility. In one embodiment, non-linear techniques can be applied at the focal point in order to limit and / or eliminate the possibility of heating the pre-focus tissue. In one embodiment, the sound pressure or supersonic intensity from the aperture can be increased to obtain a similar or substantially similar intensity at the focal plane.
在各種實施例中，如果孔徑處的幅度和相位函數是可分離的，則聲壓函數U(x1
, y1
)
的二維傅立葉變換可以表示為x
和y
的兩個函數的一維傅立葉變換的乘積。在各種實施例中，在線性或大致線性序列中產生多個TCP以及同時或幾乎同時產生多個線性序列可能是有利的。
使用頻率調製電子抖動多波束***孔徑 In various embodiments, if the amplitude and phase functions at the aperture are separable, the two-dimensional Fourier transform of the sound pressure function U (x 1 , y 1 ) can be expressed as a one-dimensional Fourier of two functions of x and y The product of the transformation. In various embodiments, it may be advantageous to generate multiple TCPs in a linear or substantially linear sequence and multiple linear sequences simultaneously or nearly simultaneously.
Multi-beam splitting aperture using frequency modulation electronic dithering
在各種實施例中，表2示出了針對給定操作頻率（例如，在各種實施例中，4MHz、7MHz、10MHz）用於實現兩個同時焦點之間的特定距離的孔徑空間頻率。方程式（11c）示出了焦點之間的分離距離也是操作頻率的函數。例如，在一個實施例中，孔徑的空間頻率（kx
）固定為1.0mm-1
，並且允許操作頻率變化。可以重寫方程式11c以示出如何通過操作頻率調製焦點分離距離。
s = (kx
zf
vc
)/(p fop
) （14）In various embodiments, Table 2 shows the aperture spatial frequencies used to achieve a specific distance between two simultaneous focal points for a given operating frequency (eg, 4 MHz, 7 MHz, 10 MHz in various embodiments). Equation (11c) shows that the separation distance between focal points is also a function of the operating frequency. For example, in one embodiment, the spatial frequency of the aperture (k x ) is fixed at 1.0 mm -1 and the operating frequency is allowed to vary. Equation 11c can be rewritten to show how the focus separation distance can be modulated by operating frequency.
s = (k x z f v c ) / (pf op ) (14)
其中kx
是空間頻率，單位為mm-1
，zf
是孔徑的焦深，單位為mm，vc
是傳播介質（例如水）中的超音速度，單位為mm/μsec，並且fop
是孔徑的操作頻率，單位為MHz。在一個實施例中，在方程式11c中進行以下替換：
l = vc
/fop
（15）Where k x is the spatial frequency, the unit is mm -1 , z f is the focal depth of the aperture, the unit is mm, v c is the supersonic velocity in the propagation medium (such as water), the unit is mm / μsec, and f op is The operating frequency of the aperture, in MHz. In one embodiment, the following substitution is made in Equation 11c:
l = v c / f op (15)
如方程式（14）中所示，焦點的分離距離是操作頻率的函數。此外，對於操作頻率的分離距離的變化率為：
ds/dfop
=-(kx
zf
vc
)/(p fop 2
) （16）As shown in equation (14), the separation distance of the focal point is a function of the operating frequency. In addition, the rate of change of the separation distance for the operating frequency is:
ds / df op =-(k x z f v c ) / (pf op 2 ) (16)
方程式（16）表明，分離距離隨著操作頻率的增加而減小。表3（下面）示出了對於不同空間頻率（例如，在各種實施例中，4MHz、7MHz、10MHz）作為操作頻率的函數的分離距離的變化率。
如表3中所示，隨著操作頻率的增加，焦點變得更接近，並且隨著操作頻率的減小，焦點變得更遠，而無需改變相位或機械地移動換能器。這是一種電子地移動波束以擴展能量而不依賴於組織中的熱傳導的獨特方法。益處包括最大溫度的降低或最小化以及病變的熱凝固體積的增加，而不需要額外的系統通道。As shown in Table 3, as the operating frequency increases, the focus becomes closer, and as the operating frequency decreases, the focus becomes farther without changing the phase or mechanically moving the transducer. This is a unique method of moving the beam electronically to spread energy without relying on heat conduction in the tissue. Benefits include the reduction or minimization of the maximum temperature and the increase in the thermal coagulation volume of the lesion without the need for additional system channels.
可以通過使用方程式（14）來確定從主操作頻率的移動量。在一個實施例中，孔徑的主操作頻率是5MHz並且焦距是15mm。在一些實施例中，操作頻率被稱為孔徑中心頻率。在一個實施例中，操作頻率是5MHz。在一個實施例中，圖5中的表4示出了針對5MHz的中心頻率設計的具有不同空間頻率（kx = 0.5、1.0、1.5、2.0，單位為mm-1 ）的孔徑的焦點分離量。它還計算從5MHz的中心頻率的焦點的擴展量。根據一個實施例，間隔對於相對於5MHz的較高頻率減小，並且對於相對於5MHz的較低頻率增加。The amount of movement from the main operating frequency can be determined by using equation (14). In one embodiment, the main operating frequency of the aperture is 5 MHz and the focal length is 15 mm. In some embodiments, the operating frequency is referred to as the aperture center frequency. In one embodiment, the operating frequency is 5MHz. In one embodiment, Table 4 in FIG. 5 shows the amount of focus separation with apertures of different spatial frequencies (kx = 0.5, 1.0, 1.5, 2.0 in mm -1 ) designed for a center frequency of 5 MHz. It also calculates the amount of focus expansion from a center frequency of 5MHz. According to one embodiment, the spacing decreases for higher frequencies relative to 5MHz, and increases for lower frequencies relative to 5MHz.
圖6示出了針對不同孔徑空間頻率的孔徑的所有操作頻率的間隔差異。如圖6所示，分離距離隨著頻率的減小而增加。Figure 6 shows the difference in spacing of all operating frequencies for apertures for different aperture spatial frequencies. As shown in Figure 6, the separation distance increases with decreasing frequency.
在一個實施例中，分離距離相對於頻率5MHz。在一個實施例中，可以通過參考到5MHz處的初始分離的所有移動來確定從頻率調製估計電子抖動的一種方式。如圖7所示，焦點之間的分離距離的擴展可以容易地變化超過1mm。In one embodiment, the separation distance is 5 MHz relative to the frequency. In one embodiment, a way to estimate electronic jitter from frequency modulation can be determined by referring to all movements to the initial separation at 5 MHz. As shown in FIG. 7, the expansion of the separation distance between focal points can easily vary by more than 1 mm.
在各種實施例中，可以根據換能器帶寬來描述來自一個孔徑的可能操作頻率的範圍。在一個實施例中，較大的換能器帶寬導致具有較寬範圍的操作頻率的孔徑。通過定位發射強度減小到峰值發射強度的-3dB的頻率，可以將換能器帶寬描述為孔徑中心頻率的百分數。在一個實施例中，對於換能器孔徑的發射響應，-3dB高頻被指定為f-3db,H
並且-3dB低頻被指定為f-3dB, L
。以[MHz]為單位的-3dB中心頻率被描述為：
f-3dB ， center
= (f-3dB ， H
+ f-3dB ， L
)/2 （17）In various embodiments, the range of possible operating frequencies from one aperture can be described in terms of transducer bandwidth. In one embodiment, a larger transducer bandwidth results in an aperture with a wider range of operating frequencies. By locating the frequency at which the emission intensity decreases to -3dB of the peak emission intensity, the transducer bandwidth can be described as a percentage of the center frequency of the aperture. In one embodiment, for the emission response of the transducer aperture, a high frequency of -3dB is designated as f- 3db, H and a low frequency of -3dB is designated as f- 3dB, L. The -3dB center frequency in [MHz] is described as:
f -3dB , center = (f -3dB , H + f -3dB , L ) / 2 (17)
-3dB百分比帶寬被描述為：
BW-3dB
= 100%* (f-3dB ， H
- f-3dB ， L
)/ ((f-3dB ， H
+f-3dB ， L
)/2) （18）The -3dB percentage bandwidth is described as:
BW -3dB = 100% * (f -3dB , H -f -3dB , L ) / ((f -3dB , H + f -3dB , L ) / 2) (18)
在一些實施例中，可以通過使用（但不限於）背襯層、匹配層、多個壓電層、電匹配、壓電複合材料和/或單晶壓電陶瓷來實現增加一個孔徑內可能的操作頻率範圍。在一個實施例中，隨著換能器帶寬的增加，可能的分離距離的範圍增加。表5（下面）示出了如果孔徑中心頻率為5MHz，則基於百分比帶寬焦點擴展可以如何改變。對於0.5mm-1
、1.00mm-1
、1.50mm-1
、2.00mm-1
的空間頻率，5MHz的焦點分離距離分別為0.72mm、1.43mm、2.15mm和2.86mm。如果孔徑處的空間頻率為1.50mm-1
且換能器帶寬為60％，則焦點之間的分離距離變化1.42mm，其是大於5MHz處波束的橫向分辨率的距離。
從5MHz中心頻率的附加擴展，單位為[mm]
Additional extension from 5MHz center frequency in [mm]
在一個實施例中，隨著頻率改變、景深以及橫向分辨率和焦點增益也將改變。在一個實施例中，隨著頻率改變、景深、橫向分辨率和焦點增益也將改變。因此，在一個實施例中，孔徑處的強度可以根據加熱速率目標而改變。而且，在一些實施例中，同時發送多個操作頻率以立即或接近立即地擴展能量可能是有利的。例如，孔徑的發射激勵可以包括在4MHz、5MHz和6MHz處的激勵，它們所有都在同時。
通過改變孔徑空間頻率實現多個焦點 In one embodiment, as frequency changes, depth of field and lateral resolution and focus gain will also change. In one embodiment, as frequency changes, depth of field, lateral resolution, and focus gain will also change. Therefore, in one embodiment, the intensity at the aperture can be changed according to the heating rate target. Moreover, in some embodiments, it may be advantageous to send multiple operating frequencies simultaneously to spread energy immediately or nearly immediately. For example, the transmission excitation of the aperture may include excitation at 4 MHz, 5 MHz, and 6 MHz, all of them at the same time.
Multiple focal points by changing the spatial frequency of the aperture
如方程14所示，孔徑空間頻率越高，焦點之間的分離距離越大。在一個實施例中，孔徑以空間頻率kx 極化。通過連接具有將相位修改為0度或180度的能力的單獨的電激勵通道，空間頻率可以容易地加倍或減小到零，如圖8中的實施例所示。例如，如果通道1至16上的相位為0度，則孔徑空間頻率為kx 。在實施例中，當每個通道上的相位從0度變化到180度使得奇數通道處於0度並且偶數通道處於180度時，則孔徑處的空間頻率為½kx 。在實施例中，如果相位每兩個通道重複使得通道1和通道2為0度並且通道3和通道4為180度，依此類推，則孔徑處的空間頻率為0。如果通道1為0度，通道2為180度，通道3為180度，通道4為0度，依此類推，則孔徑處的空間頻率為2kx 。在該情況下，可以產生七個獨特的焦點。如表4中所示（在圖5），如果孔徑中心頻率為5MHz，並且孔徑頻率是0mm-1 、0.5mm-1 、1.0mm-1 或2.0mm-1 中的任何一個，則相應的分離距離為0mm、0.72mm、1.43mm和2.86mm，其產生分離0.36mm的七個獨特的焦點位置。在各種實施例中，0度和180度之間的中間相位將進一步允許兩個焦點傾斜，使得可以在焦平面處產生焦點線。最終，傾斜、焦點位置的調製和頻率調製能夠加熱並且可能凝固具有約2.86mm的長度的整個線。As shown in Equation 14, the higher the spatial frequency of the aperture, the greater the separation distance between focal points. In one embodiment, the aperture spatial frequency k x polarization. By connecting separate electrical excitation channels with the ability to modify the phase to 0 degrees or 180 degrees, the spatial frequency can be easily doubled or reduced to zero, as shown in the embodiment in FIG. 8. For example, if the phase on channels 1 to 16 is 0 degrees, the aperture spatial frequency is k x . In an embodiment, when the phase on each channel changes from 0 degrees to 180 degrees so that odd channels are at 0 degrees and even channels are at 180 degrees, then the spatial frequency at the aperture is ½k x . In an embodiment, if the phase is repeated every two channels so that channel 1 and channel 2 are 0 degrees and channel 3 and channel 4 are 180 degrees, and so on, the spatial frequency at the aperture is 0. If channel 1 is 0 degrees, channel 2 is 180 degrees, channel 3 is 180 degrees, channel 4 is 0 degrees, and so on, the spatial frequency at the aperture is 2k x . In this case, seven unique focal points can be generated. As shown in Table 4 (in Figure 5), if the center frequency of the aperture is 5 MHz and the aperture frequency is any of 0mm -1 , 0.5mm -1 , 1.0mm -1 or 2.0mm -1 , the corresponding separation The distances are 0mm, 0.72mm, 1.43mm and 2.86mm, which produces seven unique focal positions separated by 0.36mm. In various embodiments, an intermediate phase between 0 degrees and 180 degrees will further allow the two focal points to tilt, making it possible to produce focal lines at the focal plane. Eventually, the modulation of the tilt, focus position, and frequency modulation can heat and possibly solidify the entire wire with a length of about 2.86 mm.
在一個實施例中，極化陶瓷具有2kx 的空間頻率，如圖9中所示。在該情況下，每個電通道覆蓋陶瓷（例如，壓電陶瓷）中的兩個極化區域。如果通道1至通道8具有相同的電相位，則孔徑的空間頻率為2kx 。如果相位交替使得奇數通道具有0度的相位並且偶數通道具有180度的相位，則孔徑的空間頻率為kx 。在一個實施例中，在通道上僅可能有兩個相位的該配置能夠實現四個獨特的焦點。在各種實施例中，如果附加相位是可允許的，則可以將兩個焦點傾斜到許多不同的焦點位置。該配置限制了獲得多個焦點位置所需的電子通道的數量。In one embodiment, the polarized ceramic has a spatial frequency of 2k x as shown in FIG. 9. In this case, each electrical channel covers two polarized regions in ceramic (eg, piezoelectric ceramic). If channels 1 to 8 have the same electrical phase, the spatial frequency of the aperture is 2k x . If the phases are alternated so that odd channels have a phase of 0 degrees and even channels have a phase of 180 degrees, the spatial frequency of the aperture is k x . In one embodiment, this configuration with only two phases on the channel can achieve four unique focal points. In various embodiments, if additional phases are allowable, the two focal points can be tilted to many different focal positions. This configuration limits the number of electronic channels required to obtain multiple focal positions.
在若干實施例中，治療系統利用多個治療通道來實現電子聚焦和/或轉向。例如，利用多個治療通道實現電子聚焦和/或轉向的治療系統允許更快的電子抖動以使用與其他治療裝置相同的能量產生更多的熱凝固，或者使用具有比其他治療裝置更少能量的電子抖動產生相等的熱凝固。該技術拓寬了裝置提供的功效和舒適統一體。除了電子抖動之外，多個治療通道還可以將波束移動到不同的深度位置，例如兩個傳統的換能器，如DS7-4.5（4.5mm深度處7MHz）和DS7-3.0（3.0mm深度處7MHz），可以由在兩個不同深度之間移動的單個裝置代替。In several embodiments, the treatment system utilizes multiple treatment channels to achieve electronic focusing and / or steering. For example, a treatment system that utilizes multiple treatment channels to achieve electronic focusing and / or steering allows for faster electronic shaking to use the same energy as other treatment devices to generate more thermal coagulation, or to use less energy than other treatment devices Electronic shaking produces equal thermal solidification. This technology broadens the unity of efficiency and comfort provided by the device. In addition to electronic dithering, multiple treatment channels can also move the beam to different depth positions, such as two traditional transducers, such as DS7-4.5 (7MHz at a depth of 4.5mm) and DS7-3.0 (at a depth of 3.0mm) 7MHz), can be replaced by a single device that moves between two different depths.
在一個實施例中，具有經連接以使波束軸向移動的多個治療通道281的換能器280（例如環形陣列）通常首先在深的深度處產生TCP 550，然後移動到較淺的深度。在另一實施例中，TCP 550在淺深度處產生，然後在皮膚表面下方更深的深度處產生。這依序地產生TCP 550並將導致治療時間延長。例如，在一個實施例中，如果用於深TCP 550的時間是tdeep
並且用於淺TCP 550的時間是tshallow
，則用於兩個TCP 550的總治療時間是兩個治療時間的總和，tdeep
加上tshallow
。在一個實施例中，通過使用信號混合技術同時形成多個（兩個或更多個）TCP 550來減少總治療時間，所述信號混合技術在每個通道處使用信號切趾（遮蔽）和相位控制。在一個實施例中，總治療時間是tdeep
和tshallow
的最大值：
治療時間，常規方法：ttreatment
= tdeep
+ tshallow
治療時間，信號混合：ttreatment
= max(tdeep
, tshallow
)In one embodiment, a transducer 280 (eg, an annular array) with multiple treatment channels 281 connected to move the beam axially typically produces TCP 550 at a deep depth first, and then moves to a shallower depth. In another embodiment, TCP 550 is generated at a shallow depth and then at a deeper depth below the skin surface. This generates TCP 550 in sequence and will lead to longer treatment times. For example, in one embodiment, if the time for deep TCP 550 is t deep and the time for shallow TCP 550 is t shallow , then the total treatment time for two TCP 550 is the sum of the two treatment times, t deep plus t shallow . In one embodiment, the total treatment time is reduced by simultaneously forming multiple (two or more) TCP 550s using signal mixing techniques that use signal apodization (shading) and phase at each channel control. In one embodiment, the total treatment time is the maximum of t deep and t shallow :
Treatment time, conventional method: t treatment = t deep + t shallow
Treatment time, signal mixing: t treatment = max (t deep , t shallow )
在實施例中，環形陣列設計280能夠實現治療波束在深度上的電子移動（例如，通過改變皮膚表面下方的TCP 550的深度）。在一個實施例中，換能器280包括具有固定機械焦點的八個治療通道環形換能器元件281。圖10示出了該陶瓷環形陣列設計280的一個實施例的俯視圖，其中成像換能器285處於碗的中心。在該實施例中，治療環形換能器280具有標識為Tx0至Tx7的八個環，對應於元件281。
換能器 In an embodiment, the circular array design 280 enables electronic movement of the treatment beam in depth (eg, by changing the depth of the TCP 550 below the skin surface). In one embodiment, the transducer 280 includes eight treatment channel annular transducer elements 281 with a fixed mechanical focus. FIG. 10 shows a top view of one embodiment of the ceramic ring array design 280, where the imaging transducer 285 is in the center of the bowl. In this embodiment, the therapeutic ring transducer 280 has eight rings identified as Tx0 to Tx7, corresponding to element 281.
Transducer
在一個實施例中，換能器280球形地聚焦到一個或多個點。在一個實施例中，換能器280圓柱形地聚焦到一條或多條線。換能器280的各種實施例包括具有透鏡的扁平壓電器。在各種實施例中，換能器280包括凸側282和凹側283。在各種實施例中，換能器280包括凸側282和凹側283，其具有提供可變深度、可變間隔、可變焦距定位，具有一個、兩個、三個、四個或更多同時聚焦區域中的任何一個或多個的特徵。在各種實施例中，換能器280電連接到一個或多個調諧電路。調諧電路改善控制台和換能器之間的電信號。在各種實施例中，一個或多個調諧電路位於換能器的殼體中，位於換能器和控制台之間的連接中，和/或位於控制台中。In one embodiment, the transducer 280 is spherically focused to one or more points. In one embodiment, the transducer 280 is cylindrically focused to one or more lines. Various embodiments of the transducer 280 include flat piezoelectrics with lenses. In various embodiments, the transducer 280 includes a convex side 282 and a concave side 283. In various embodiments, the transducer 280 includes a convex side 282 and a concave side 283 that have variable depth, variable spacing, and variable focal length positioning, with one, two, three, four, or more simultaneous Any one or more features in the focus area. In various embodiments, the transducer 280 is electrically connected to one or more tuning circuits. The tuning circuit improves the electrical signal between the console and the transducer. In various embodiments, one or more tuning circuits are located in the housing of the transducer, in the connection between the transducer and the console, and / or in the console.
圖11示出了換能器280的實施例，所述換能器包括具有凸側282和凹側283的單個元件。圖12示出了包括固體塗層凸側282和條帶狀凹側283的換能器280的實施例，其中條帶包括第一極化區域和第二極化區域，其中極化區域是正極，負極或未極化。圖12示出了包括固體塗層凸側282和條帶狀凹側283的換能器280的實施例，其中條帶包括第一區域和第二區域，其中區域可以包括塗層或不包括塗層。在一個實施例中，單個電極設置在凸表面上，凹表面上的極化條帶連接到兩個通道（例如，圖12）。條帶可以交替以***波束或僅包括一個相以模擬傳統的換能器。這將允許一個換能器模擬DS4-4.5S和DS4-4.5的處理，因此可以通過一個換能器放置來產生三條線。FIG. 11 shows an embodiment of a transducer 280 that includes a single element with a convex side 282 and a concave side 283. 12 shows an embodiment of a transducer 280 that includes a solid coated convex side 282 and a strip-shaped concave side 283, where the strip includes a first polarized region and a second polarized region, where the polarized region is the positive electrode , Negative or unpolarized. 12 shows an embodiment of a transducer 280 that includes a solid coated convex side 282 and a strip-shaped concave side 283, where the strip includes a first region and a second region, where the region may or may not include a coating Floor. In one embodiment, a single electrode is provided on the convex surface, and the polarized strip on the concave surface is connected to two channels (eg, FIG. 12). The stripes can alternate to split the beam or include only one phase to simulate a traditional transducer. This will allow one transducer to simulate the processing of DS4-4.5S and DS4-4.5, so that three lines can be generated by placing one transducer.
圖13示出了包括條帶狀凸側282和固體塗層凹側283的換能器280的實施例，其中條帶包括第一極化區域和第二極化區域，其中極化區域是正極，負極或未極化。圖13示出了包括條帶狀凸側282和固體塗層凹側283的換能器280的實施例，其中條帶包括第一區域和第二區域，其中區域可以包括塗層或不包括塗層。在各種實施例中，條帶電連接到一個或多個通道。在一個實施例中，奇數條帶連接到第一通道並且偶數條帶連接到第二通道。在一個實施例中，第一通道保持在0°，而第二通道在0°和180°之間交替（反之亦然）。來自第一通道的聚焦的超音能量保持在單個中心位置，來自第二（交替）通道的聚焦的超音能量產生兩個間隔開的聚焦區域。來自第一（恆定）和第二（交替）通道的聚焦的超音能量一起產生三個同時TCP。在一個實施例中，單個電極設置在凹表面上，在凸表面上的極化條帶連接到兩個通道（例如，圖13）。條帶可以交替以***波束或僅包括一個相位以模擬傳統的換能器。這將允許一個換能器模擬DS4-4.5S和DS4-4.5的處理，因此可以通過一個換能器放置來產生三條線。13 shows an embodiment of a transducer 280 that includes a strip-shaped convex side 282 and a solid coated concave side 283, where the strip includes a first polarized region and a second polarized region, where the polarized region is a positive electrode , Negative or unpolarized. 13 shows an embodiment of a transducer 280 that includes a strip-shaped convex side 282 and a solid coated concave side 283, where the strip includes a first region and a second region, where the region may or may not include a coating Floor. In various embodiments, the strip is electrically connected to one or more channels. In one embodiment, odd strips are connected to the first channel and even strips are connected to the second channel. In one embodiment, the first channel is maintained at 0 °, while the second channel alternates between 0 ° and 180 ° (or vice versa). The focused supersonic energy from the first channel is maintained at a single center position, and the focused supersonic energy from the second (alternate) channel produces two spaced-apart focus areas. The focused supersonic energy from the first (constant) and second (alternating) channels together produce three simultaneous TCPs. In one embodiment, a single electrode is provided on the concave surface, and the polarized strip on the convex surface is connected to two channels (eg, FIG. 13). The strips can be alternated to split the beam or include only one phase to simulate a traditional transducer. This will allow one transducer to simulate the processing of DS4-4.5S and DS4-4.5, so that three lines can be generated by placing one transducer.
圖14示出了包括條帶狀凸側282和條帶狀凹側283的換能器280的實施例，其中條帶包括第一極化區域和第二極化區域，其中極化區域是正極，負極或未極化，其中條帶狀區域相對於彼此以約90度的取向旋轉。圖14示出了包括條帶狀凸側282和固體塗層凹側283的換能器280的實施例，其中條帶包括第一區域和第二區域，其中區域可以包括塗層或不包括塗層，並且其中條帶相對於彼此旋轉約90度。14 shows an embodiment of a transducer 280 that includes a strip-shaped convex side 282 and a strip-shaped concave side 283, where the strip includes a first polarization region and a second polarization region, where the polarization region is a positive electrode , Negative or unpolarized, where the strip-shaped regions rotate at an orientation of about 90 degrees relative to each other. 14 shows an embodiment of a transducer 280 that includes a strip-shaped convex side 282 and a solid coated concave side 283, where the strip includes a first region and a second region, where the region may or may not include a coating Layers, and where the strips are rotated about 90 degrees relative to each other.
圖15示出了包括條帶狀凸側282和環形凹側283的換能器280的實施例，其中條帶包括第一極化區域和第二極化區域，其中極化區域是正極，負極或未極化。圖15示出了包括條帶狀凸側282和環形凹側283的換能器280的實施例，其中條帶包括第一區域和第二區域，其中區域可以包括塗層或不包括塗層。15 shows an embodiment of a transducer 280 that includes a strip-shaped convex side 282 and an annular concave side 283, where the strip includes a first polarized region and a second polarized region, where the polarized region is positive and negative Or not polarized. 15 shows an embodiment of a transducer 280 that includes a strip-shaped convex side 282 and an annular concave side 283, where the strip includes a first region and a second region, where the region may or may not include a coating.
圖16示出了包括環形凸側282和條帶狀凹側283的換能器280的實施例，其中條帶包括第一極化區域和第二極化區域，其中極化區域是正極，負極或未極化。圖16示出了包括環形凸側282和條帶狀凹側283的換能器280的實施例，其中條帶包括第一區域和第二區域，其中區域可以包括塗層或不包括塗層。16 shows an embodiment of a transducer 280 that includes an annular convex side 282 and a strip-shaped concave side 283, where the strip includes a first polarized region and a second polarized region, where the polarized region is positive and negative Or not polarized. Figure 16 shows an embodiment of a transducer 280 that includes an annular convex side 282 and a strip-shaped concave side 283, where the strip includes a first region and a second region, where the region may or may not include a coating.
在一些實施例中，系統包括作為單個特徵（與多個特徵不同）存在的各種特徵。例如，在一個實施例中，該系統包含，基本上包括或包括單個超音換能元件，所述單個超音換能元件適於經由抖動提供兩個同時治療區域。在替代實施例中提供了多個特徵或部件。
多個深度處的同時治療 In some embodiments, the system includes various features that exist as a single feature (unlike multiple features). For example, in one embodiment, the system includes, substantially includes, or includes a single supersonic transducer element that is adapted to provide two simultaneous treatment areas via dithering. In alternative embodiments, multiple features or components are provided.
Simultaneous treatment at multiple depths
在各種實施例中，治療系統配置成產生沿著機械運動線以相等距離分離的組織中的多個微凝固區域。在各種實施例中，治療系統提供不同的模組、盒或不同的換能器（例如，DS4-4.5、DS7-4.5、DS7-3.0、DS10-1.5、DS7-3.0N、DS10-1.5N或者OT4-4.5、OT7-4.5、OT7-3.0、OT10-1.5，其中第一個數字代表治療頻率並且第二個數字代表治療遞送的深度。後兩個換能器的'N'表示該裝置是窄換能器，其用於難以到達的區域，如鼻和嘴周圍。前四個換能器可以沿著25mm線遞送治療，而窄換能器提供14mm的最大線長度）。在各種實施例中，具有環形電極和極化陶瓷的換能器能夠實現橫向維度的頻率抖動、深度維度的電子抖動、深度維度的電子聚焦以及單個換能器，其可以在一個換能器中模擬DS10-1.5（1.5mm深度處10MHz）、DS7-3.0（3.0 mm深度處7MHz）、DS7-4.5（4.5 mm深度處7MHz）和DS4-4.5（4.5 mm深度處4MHz）。在一個實施例中，可選擇的調諧電子器件可以與複合陶瓷組合使用以使得具有環形電極和極化陶瓷的換能器能夠實現橫向維度的頻率抖動、深度維度的電子抖動、深度維度的電子聚焦的功能。在各種實施例中，一個、兩個、三個或更多個可選擇的調諧電路有助於穩定控制台和換能器之間的信號，並且可以呈現在換能器殼體中，在換能器和控制台之間或者在控制台中。In various embodiments, the treatment system is configured to generate multiple microcoagulation regions in tissue separated by equal distances along the mechanical motion line. In various embodiments, the treatment system provides different modules, boxes, or different transducers (eg, DS4-4.5, DS7-4.5, DS7-3.0, DS10-1.5, DS7-3.0N, DS10-1.5N, or OT4-4.5, OT7-4.5, OT7-3.0, OT10-1.5, where the first number represents the treatment frequency and the second number represents the depth of treatment delivery. The 'N' of the last two transducers indicates that the device is narrow Transducers, which are used in hard-to-reach areas such as around the nose and mouth. The first four transducers can deliver treatment along a 25mm line, while narrow transducers provide a maximum line length of 14mm). In various embodiments, a transducer with a ring electrode and a polarized ceramic can achieve frequency jitter in the lateral dimension, electronic jitter in the depth dimension, electronic focusing in the depth dimension, and a single transducer, which can be in a single transducer The simulations are DS10-1.5 (10MHz at 1.5mm depth), DS7-3.0 (7MHz at 3.0mm depth), DS7-4.5 (7MHz at 4.5mm depth), and DS4-4.5 (4MHz at 4.5mm depth). In one embodiment, selectable tuning electronics can be used in combination with composite ceramics to enable transducers with ring electrodes and polarized ceramics to achieve frequency jitter in the lateral dimension, electronic jitter in the depth dimension, and electronic focusing in the depth dimension Function. In various embodiments, one, two, three, or more selectable tuning circuits help to stabilize the signal between the console and the transducer, and can be presented in the transducer housing. Between the device and the console or in the console.
在一個實施例中，全面部治療用換能器遞送800個治療線，其涉及操作者在約70至90分鐘內沿著患者皮膚移動手持機。在一個實施例中，單個治療碗被配置用於同時遞送兩個治療線（例如，DS4-4.5S、DS4-3.0S、OT4-4.5S或OT4-3.0S），基於最近的臨床研究，其可以使治療遞送時間減少約40％。在各種實施例中，如果以正確的能量操作，治療裝置提供相當水平的功效。在各種實施例中，同時治療減少治療的總體疼痛。在一個實施例中，同時治療時間明顯縮短，假設治療的總體疼痛較少。In one embodiment, a total treatment transducer delivers 800 treatment lines, which involves the operator moving the handset along the patient's skin in about 70 to 90 minutes. In one embodiment, a single treatment bowl is configured to deliver two treatment lines simultaneously (eg, DS4-4.5S, DS4-3.0S, OT4-4.5S, or OT4-3.0S), based on recent clinical studies, which Treatment delivery time can be reduced by about 40%. In various embodiments, if operated with the correct energy, the treatment device provides a considerable level of efficacy. In various embodiments, simultaneous treatment reduces the overall pain treated. In one embodiment, while the treatment time is significantly shortened, it is assumed that the overall pain of the treatment is less.
在各種實施例中，同時治療將使治療速度增加10％、20％、25％、30％、40％、50％、60％或以上。在各種實施例中，同時治療將使治療時間減少10％、20％、25％、30％、40％、50％、60％或以上。在各種實施例中，系統配置成在60、50、40、30、20或10分鐘或更短的時間內完成治療時間。In various embodiments, simultaneous treatment will increase the treatment rate by 10%, 20%, 25%, 30%, 40%, 50%, 60% or more. In various embodiments, simultaneous treatment will reduce treatment time by 10%, 20%, 25%, 30%, 40%, 50%, 60% or more. In various embodiments, the system is configured to complete the treatment time in 60, 50, 40, 30, 20, or 10 minutes or less.
在一個實施例中，同時治療系統同時產生兩個線，具有在熱凝固區域550處移動微凝固深度的能力。在一個實施例中，治療換能器的帶寬增加，則可能具有一個裝置，其表現類似於兩個、三個、四個、五個或六個固定深度裝置。在一個實施例中，使用8通道治療裝置。In one embodiment, the simultaneous treatment system produces two lines simultaneously, with the ability to move the depth of microcoagulation at the thermal coagulation zone 550. In one embodiment, as the bandwidth of the therapeutic transducer increases, it is possible to have a device that behaves like two, three, four, five, or six fixed depth devices. In one embodiment, an 8-channel treatment device is used.
圖17示出了包括環形凸側282和條帶狀凹側283的換能器280的實施例，其中條帶包括第一極化區域和第二極化區域，其中極化區域是正極、負極或未極化。圖17示出了包括環形凸側282和條帶狀凹側283的換能器280的實施例，其中條帶包括第一區域和第二區域，其中區域可以包括塗層或不包括塗層。在一個實施例中，與同時換能器耦合的環形陣列使得能夠在皮膚表面下方的不同深度279（例如，D1 、D2 、D3 、... DN ）處同時產生兩個聚焦超音治療線。在一個實施例中，凹側283上的條帶交替地極化（例如，在0度和180度等）。在各種實施例中，深度279為1.5mm、3.0mm、4.0mm、4.5mm或7mm。在一個實施例中，D1 = 1.5mm、D2 = 3.0mm並且D = 4.5mm。在各種實施例中，深度279為0.5mm、1.0mm、1.5mm、2mm、3mm、4mm、4.5mm、6mm、7mm、小於3mm、在0.5mm至5mm之間、在1.5mm至4.5mm之間、大於4.5 mm、大於6 mm、7 mm、以及0.1 mm-3 mm、0.1 mm-4.5 mm、0.1 mm-25 mm、0.1 mm-100 mm的範圍內的任何點，和其中的任何深度（例如，6mm、7mm、10mm、13mm、15mm、17mm）。在實施例中，在多個深度處的同時治療在不同深度279處產生多個熱凝固區域550。圖17示出了同時治療碗的實施例的兩側。在治療碗的一側是用於執行交替極化的條帶。在一個實施例中，條帶在凹側283上。在一個實施例中，條帶在凸側282上。在一個實施例中，在完成極化之後，剝離電極並在整個側上放置完整的電極。在一個實施例中，冷銀電極也可以用於連接條帶。在一個實施例中，治療碗的相對側包括可以具有或不具有相等面積的同心環。當正確的相位施加到治療碗時，環形陣列能夠實現深度上的波束移動。FIG. 17 shows an embodiment of a transducer 280 that includes an annular convex side 282 and a strip-shaped concave side 283, where the strip includes a first polarized region and a second polarized region, where the polarized regions are positive and negative Or not polarized. Figure 17 shows an embodiment of a transducer 280 that includes an annular convex side 282 and a strip-shaped concave side 283, where the strip includes a first region and a second region, where the region may or may not include a coating. In one embodiment, the annular array coupled with the simultaneous transducer enables simultaneous generation of two focused ultrasounds at different depths 279 (eg, D 1 , D 2 , D 3 , ... D N ) below the skin surface Sound therapy line. In one embodiment, the strips on the concave side 283 are alternately polarized (eg, at 0 degrees and 180 degrees, etc.). In various embodiments, the depth 279 is 1.5 mm, 3.0 mm, 4.0 mm, 4.5 mm, or 7 mm. In one embodiment, D 1 = 1.5 mm, D 2 = 3.0 mm, and D = 4.5 mm. In various embodiments, the depth 279 is 0.5mm, 1.0mm, 1.5mm, 2mm, 3mm, 4mm, 4.5mm, 6mm, 7mm, less than 3mm, between 0.5mm and 5mm, and between 1.5mm and 4.5mm , Greater than 4.5 mm, greater than 6 mm, 7 mm, and any point within the range of 0.1 mm-3 mm, 0.1 mm-4.5 mm, 0.1 mm-25 mm, 0.1 mm-100 mm, and any depth therein (eg , 6mm, 7mm, 10mm, 13mm, 15mm, 17mm). In an embodiment, simultaneous treatment at multiple depths produces multiple thermal coagulation regions 550 at different depths 279. Figure 17 shows both sides of an embodiment of a simultaneous treatment bowl. On one side of the treatment bowl is a strip for performing alternating polarization. In one embodiment, the strip is on the concave side 283. In one embodiment, the strip is on the convex side 282. In one embodiment, after the polarization is completed, the electrode is peeled off and the complete electrode is placed on the entire side. In one embodiment, cold silver electrodes can also be used to connect the straps. In one embodiment, the opposite side of the treatment bowl includes concentric rings that may or may not have equal areas. When the correct phase is applied to the treatment bowl, the circular array can achieve beam movement in depth.
在一個實施例中，包括環形凸側282和條帶狀凹側283的換能器280配置成在各種深度279處產生多深度熱凝固區域550，如圖18（在x-y-z空間中投影）、圖19（x-z平面）和圖20（y-z平面）中所示。圖18示出了微凝固點的三維草圖。在一個實施例中，可以同時生成兩個、三個、四個或更多個點。在一個實施例中，同時生成兩個點。在一個實施例中，預期在移動到下一個深度（例如，3.0mm）並且然後最終移動到最淺深度（例如，1.5mm）之前首先產生更深的微凝固點（例如，4.5mm）。在一個實施例中，運動機構從左向右和從右向左移動。在一個實施例中，通過在從左向右移動時在最深深度（例如，4.5mm）處形成微凝固點並且然後在從右向左移動時放置下一深度（例如，3.0mm）並且然後在再次從左向右移動時在最淺深度（例如，1.5mm）處用微凝固點完成治療，可以限制皮膚的溫度。圖19示出了沿著機械運動的方向（x軸）和深度（z軸）的治療的投影。圖20示出了沿著波束***的方向（y軸）和深度（z軸）的治療的投影。In one embodiment, the transducer 280 including the annular convex side 282 and the strip-shaped concave side 283 is configured to produce a multi-depth thermal solidification region 550 at various depths 279, as shown in FIG. 18 (projected in xyz space), 19 (xz plane) and Figure 20 (yz plane). Fig. 18 shows a three-dimensional sketch of the micro-freezing point. In one embodiment, two, three, four or more points can be generated simultaneously. In one embodiment, two points are generated simultaneously. In one embodiment, it is expected that a deeper micro-freezing point (eg, 4.5 mm) is first produced before moving to the next depth (eg, 3.0 mm) and then finally to the shallowest depth (eg, 1.5 mm). In one embodiment, the motion mechanism moves from left to right and from right to left. In one embodiment, by forming a micro-freezing point at the deepest depth (eg, 4.5 mm) when moving from left to right and then placing the next depth (eg, 3.0 mm) when moving from right to left and then again When moving from left to right at the shallowest depth (for example, 1.5mm) to complete the treatment with a micro-coagulation point, you can limit the temperature of the skin. Figure 19 shows the projection of the treatment along the direction of mechanical motion (x-axis) and depth (z-axis). Figure 20 shows the projection of the treatment along the direction of beam splitting (y-axis) and depth (z-axis).
圖21-23示出了同時多深度治療裝置的實施例，其配置成在1.5mm、3.0mm和4.5mm的深度處產生TCP，其中中間層偏離深和淺深度。在一個實施例中，包括環形凸側282和條帶狀凹側283的換能器280配置成在各種深度279處產生多個深度熱凝固區域550，如圖21（在x-y-z空間中投影）、圖22（x-z平面）和圖23（y-z平面）中所示。在一個實施例中，TCP的長度可能限制將多個深度的TCP直接堆疊在彼此的頂部上的能力。在一個實施例中，運動機構使不同深度的TCP治療彼此偏移。圖21示出了偏移多深度換能器的三維圖。對於圖18-20a描述的類似的遞送過程可以應用於圖21-23中的實施例，其中可以在從左向右或從右向左移動時遞送微凝固點以最小化對表皮或真皮或組織層的任何潛在損傷的可能性。圖22示出了沿著機械運動（x軸）和深度（z軸）的遞送的投影。這清楚地示出了TCP的中間層從深層和淺治療偏移。圖23示出了沿著波束***的方向（y軸）和深度（z軸）的遞送的投影。21-23 show an embodiment of a simultaneous multi-depth treatment device configured to generate TCP at depths of 1.5 mm, 3.0 mm, and 4.5 mm, with the middle layer deviating from deep and shallow depths. In one embodiment, the transducer 280 including the annular convex side 282 and the strip-shaped concave side 283 is configured to produce multiple deep thermal solidification regions 550 at various depths 279, as shown in FIG. 21 (projected in xyz space), Shown in Figure 22 (xz plane) and Figure 23 (yz plane). In one embodiment, the length of TCP may limit the ability to stack multiple depths of TCP directly on top of each other. In one embodiment, the motion mechanism offsets TCP treatments of different depths from each other. Figure 21 shows a three-dimensional view of an offset multi-depth transducer. A similar delivery process as described for FIGS. 18-20a can be applied to the embodiments of FIGS. 21-23, where the microcoagulation point can be delivered when moving from left to right or from right to left to minimize the epidermal or dermal or tissue layer The possibility of any potential damage. Figure 22 shows the projection of delivery along mechanical motion (x-axis) and depth (z-axis). This clearly shows that the middle layer of TCP is offset from deep and shallow treatment. Figure 23 shows the projection of the delivery along the direction of beam splitting (y-axis) and depth (z-axis).
圖24-26示出了同時多深度治療裝置的實施例，其配置成在1.5mm、3.0mm和4.5mm的深度處產生TCP，其中中間層以變化的節距從淺深度偏移。在一個實施例中，運動機構可以用於匹配單線治療中的TCP之間的分離距離。圖24-26示出了多深度同時治療的三維草圖。在該情況下在實施例中，4.5mm深度治療以一個節距（分開1.5mm）遞送，而3.0mm深度和1.5mm深度治療以另一節距（例如分開1.1mm）遞送。儘管1.5mm深度和3.0mm深度治療處於相同節距（例如1.1mm），但運動機構允許施加偏移以防止微凝固點的堆疊。圖25示出了沿著機械運動（x軸）和深度（z軸）的遞送的投影。這清楚地示出了TCP的中間層從淺治療偏移，即使節距相同。類似地，最深治療相對於另外兩個深度處於略大的節距。圖26示出了沿著波束***的方向（y軸）和深度（z軸）的遞送的投影。24-26 show an embodiment of a simultaneous multi-depth treatment device configured to generate TCP at depths of 1.5 mm, 3.0 mm, and 4.5 mm, with the intermediate layer offset from shallow depths at varying pitches. In one embodiment, a kinematic mechanism can be used to match the separation distance between TCPs in single-line therapy. Figure 24-26 shows a three-dimensional sketch of multi-depth simultaneous treatment. In this case in the embodiment, the 4.5 mm depth treatment is delivered at one pitch (1.5 mm apart), while the 3.0 mm depth and 1.5 mm depth treatment is delivered at another pitch (eg 1.1 mm apart). Although the 1.5mm depth and 3.0mm depth treatments are at the same pitch (eg 1.1mm), the movement mechanism allows an offset to be applied to prevent stacking of microcoagulation points. Figure 25 shows the projection of delivery along mechanical motion (x-axis) and depth (z-axis). This clearly shows that the middle layer of TCP is offset from the shallow treatment, even if the pitch is the same. Similarly, the deepest treatment is at a slightly larger pitch relative to the other two depths. Figure 26 shows the projection of the delivery along the direction of beam splitting (y-axis) and depth (z-axis).
在各種實施例中，包括環形凸側282和條帶狀凹側283的換能器280（例如圖16和/或圖17中所示）產生圖25、26和/或29的實施例中所示的治療模式。在實施例中，當在x-y-z空間中的投影中觀察時，具有環形凸側282和條帶狀凹側283的換能器280在焦點區域的中心附近產生強度峰值（例如，在圖18和19中），其中環形凸側282中的每個環的控制具有幅度（A）和相位（θ）。在該情況下，基於條帶的極化在一個深度處產生同時焦點。為了在每個深度處產生同時焦點，如圖18和19中所示，將不同相位（θ）和不同幅度（A）施加到每個環，以便在不同深度處產生同時焦點。不同相位使兩個焦點能夠移動到不同焦深，並且不同幅度允許焦點強度變化並因此改變組織中的加熱速率。沿著Y軸在相同深度處的兩個焦點之間的分離量由頻率，焦深和條帶的空間頻率確定（參見方程式14，其中s被求解）。可以手動或機械地移動換能器以沿著X軸精確地間隔同時焦點。在一個實施例中，中間環具有幅度A1 ，大於具有幅度A2 的下一個外環，A2 大於A3 ，...直到最外面的環幅度An ，產生更寬的強度範圍並且能夠成形為同時出現的兩個焦點。該幅度控制允許兩個焦點處的波束寬度以及影響加熱速率的強度變化。In various embodiments, a transducer 280 including an annular convex side 282 and a strip-shaped concave side 283 (eg, as shown in FIGS. 16 and / or 17) produces all of the embodiments of FIGS. 25, 26, and / or 29 The treatment mode shown. In an embodiment, when viewed in a projection in xyz space, a transducer 280 having an annular convex side 282 and a strip-shaped concave side 283 produces an intensity peak near the center of the focal area (for example, in FIGS. 18 and 19 Middle), where the control of each loop in the annular convex side 282 has an amplitude (A) and a phase (θ). In this case, the band-based polarization produces simultaneous focus at one depth. In order to produce a simultaneous focus at each depth, as shown in FIGS. 18 and 19, different phases (θ) and different amplitudes (A) are applied to each ring to produce a simultaneous focus at different depths. Different phases enable the two focal points to move to different focal depths, and different amplitudes allow the focal point intensity to change and thus change the heating rate in the tissue. The amount of separation between the two focal points at the same depth along the Y axis is determined by the frequency, the depth of focus, and the spatial frequency of the band (see Equation 14, where s is solved). The transducer can be moved manually or mechanically to precisely space the simultaneous focus along the X axis. In one embodiment, the intermediate ring has an amplitude A 1, A has an amplitude greater than the next outer ring 2, A 2 is greater than A. 3, ... until the outermost ring A n-amplitude, generating a wider range of intensities and can Formed into two focal points appearing at the same time. This amplitude control allows the beam width at the two focal points and the intensity changes that affect the heating rate.
在各種實施例中，連續波函數可以用於在皮膚表面下方的不同深度處產生同時聚焦區域，其將聚焦解的激發函數與另一解組合。在一個實施例中，第一深度（d1
）處的聚焦區域（f1
）與不同於第一深度（d1
）的第二深度（d2
）處的第二聚焦區域（f2
）同時產生。不同深度（d1
和d2
）處的兩個焦點可以經由將激勵與單個超音換能元件組合的線性系統同時產生。下表示出了每個聚焦區域和深度所需的兩組幅度和相位。由於這兩個激勵以相同的頻率發生，因此可以將每個環上的兩個激勵組合成一個幅度和一個相位。假設對於焦點＃1的1號環上的激勵寫為：
x1 ， 1
(t) = A1 ， 1
sin(wt + q1 ， 1
)
假設對於焦點＃2的1號環上的激勵寫為：
x1 ， 2
(t) = A1 ， 2
sin(wt + q1 ， 2
)
其中w是2pf，其中f是頻率並且t是時間。
X1
(t) = x1 ， 1
(t) + x1 ， 2
(t) = A1 ， 1
sin(wt + q1 ， 1
) + A1 ， 2
sin(wt + q1 ， 2
)
然而，即使這是環1上的必要激勵，也不清楚環上所需的實際幅度和相位同時適當地激勵f1
和f2
。為了確定組合效果的該新幅度（L1
）和新相位（W1
），應用以下三角恆等式：
L1
= sqrt([A1 ， 1
cos(q1 ， 1
) + A1 ， 2
cos(q1 ， 2
)]2
+ [A1 ， 1
sin(q1 ， 1
) + A1 ， 2
sin(q1 ， 2
)]2
)
W1
= tan-1
[(A1 ， 1
sin(q1 ， 1
) + A1 ， 2
sin(q1 ， 2
))/(A1 ， 1
cos(q1 ， 1
) + A1 ， 2
cos(q1 ， 2
))]
使得環1上的新激勵是：
X1
(t) = L1
sin(wt + W1
)
可以將相同的過程應用於其他環以獲得陣列解以同時產生f1
和f2
。類似地，如果希望同時遞送三個或更多個焦點，則可以使用上述恆等式重複該過程，直到僅針對每個環計算一個激勵和一個相位。例如，假設目標是同時產生三個焦點，則基於焦點1和焦點2所需的幅度和相位計算每個環的初始新幅度和新相位。接下來，將這些新幅度和相位與焦點3所需的環激發組合。
儘管使用該方法可以產生同時焦點，但是必要的幅度可能受到壓電材料飽和以及在產生多個焦點時組織吸收周圍組織中增加強度的能力的限制。必須將這些物理限制與同時產生焦點的時間優勢進行比較。In various embodiments, a continuous wave function can be used to generate simultaneous focus regions at different depths below the skin surface, which combines the excitation function of the focused solution with another solution. In one embodiment, the focus area (f 1) at a first depth (d 1) and the second depth different than the first depth (d 1) of (d 2) at the second focal area (f 2) simultaneously produce. Two focal points at different depths (d 1 and d 2 ) can be generated simultaneously via a linear system combining excitation with a single supersonic transducer element. The following table shows the two sets of amplitude and phase required for each focus area and depth. Since these two excitations occur at the same frequency, the two excitations on each ring can be combined into one amplitude and one phase. Suppose that the incentive on ring 1 of focus # 1 is written as:
x 1 , 1 (t) = A 1 , 1 sin (wt + q 1 , 1 )
Suppose that the incentive on ring 1 of focus # 2 is written as:
x 1 , 2 (t) = A 1 , 2 sin (wt + q 1 , 2 )
Where w is 2pf, where f is frequency and t is time.
X 1 (t) = x 1 , 1 (t) + x 1 , 2 (t) = A 1 , 1 sin (wt + q 1 , 1 ) + A 1 , 2 sin (wt + q 1 , 2 )
However, even if this is the necessary excitation on ring 1, it is not clear that the actual amplitude and phase required on the ring simultaneously stimulates f 1 and f 2 appropriately . To determine this new amplitude (L 1 ) and new phase (W 1 ) of the combined effect, the following triangular identity is applied:
L 1 = sqrt ([A 1 , 1 cos (q 1 , 1 ) + A 1 , 2 cos (q 1 , 2 )] 2 + [A 1 , 1 sin (q 1 , 1 ) + A 1 , 2 sin (q 1 , 2 )] 2 )
W 1 = tan -1 [(A 1 , 1 sin (q 1 , 1 ) + A 1 , 2 sin (q 1 , 2 )) / (A 1 , 1 cos (q 1 , 1 ) + A 1 , 2 cos (q 1 , 2 ))]
The new incentive on ring 1 is:
X 1 (t) = L 1 sin (wt + W 1 )
The same process can be applied to other rings to obtain an array solution to produce f 1 and f 2 at the same time. Similarly, if it is desired to deliver three or more focal points at the same time, the process can be repeated using the above-mentioned identities until only one excitation and one phase are calculated for each ring. For example, suppose the goal is to generate three focal points at the same time, then calculate the initial new amplitude and new phase of each ring based on the amplitude and phase required for focal point 1 and focal point 2. Next, combine these new amplitudes and phases with the ring excitation required for focal point 3.
Although simultaneous focal points can be generated using this method, the necessary amplitude may be limited by the saturation of the piezoelectric material and the ability of the tissue to absorb increased strength in surrounding tissue when multiple focal points are generated. These physical constraints must be compared with the time advantage of simultaneously generating focus.
圖27-29示出了同時多深度治療裝置的實施例，其配置成在1.5mm、3.0mm和4.5mm的深度處產生TCP，其中中間層偏離淺深度並且頻率用於在每個深度處產生不同的分離距離。在圖24-26中，使用運動機構使TCP的中間深度從最深和最淺的深度偏移。在各種實施例中，同時產生的TCP之間的分離量取決於治療頻率。在一個實施例中，裝置能夠以多個頻率（例如，用寬帶治療換能器）遞送治療，並且可以使用頻率調製TCP之間的距離。如對於圖18所討論的，條帶的間隔在製造時確定，原因是這通過陶瓷極化產生。較低的頻率和較深的深度產生同時產生的TCP（y-z平面）之間更寬分離。圖4a示出了具有這總不同分離程度的TCP的三維矩陣。隨著較淺深度的頻率增加和治療深度減小，同時產生的TCP之間的距離減小。圖28示出了沿著機械運動（x軸）和深度（z軸）的遞送的投影。這清楚地示出了TCP的中間層從淺和深治療的偏移，即使節距相同。圖29示出了沿著波束***的方向（y軸）和深度（z軸）的遞送的投影。該投影表明，隨著治療深度增加，TCP之間的間隔逐漸變大，這主要是由於治療中的深度和頻率變化。
在一個實施例中，如圖29中所示，可以通過改變頻率和焦深來產生不同的間隔。例如，方程式14是：
s = (2 kx
zf
l)/(2 p)
其中s是相同深度處的兩個同時焦點之間的間隔。該方程式表明焦點分離是焦深（zf）和頻率的函數（因為λ是聲速除以頻率）。假設使用相同頻率和條帶上的空間頻率。該表總結了分離1.5 mm的不同焦點的分離。
f1_____ f2_____
A1 ， 1
/θ1 ， 1
A1 ， 2
/θ1 ， 2
A2 ， 1
/θ2 ， 1
A2 ， 2
/θ2 ， 2
A3 ， 1
/θ3 ， 1
A3 ， 2
/θ3 ， 2
A4 ， 1
/θ4 ， 1
A4 ， 2
/θ4 ， 2
其中X1
= excitation (A, θ) = A1,1
sin (w1
t- θ1,1
)A1,2
sin (w2
t- θ1,2
)，以在不同距離處產生兩個同時焦點。Figures 27-29 show an embodiment of a simultaneous multi-depth treatment device configured to generate TCP at depths of 1.5mm, 3.0mm and 4.5mm, where the middle layer deviates from the shallow depth and the frequency is used to generate at each depth Different separation distances. In Figures 24-26, the kinematic mechanism is used to offset the intermediate depth of TCP from the deepest and shallowest depths. In various embodiments, the amount of separation between simultaneously generated TCPs depends on the frequency of treatment. In one embodiment, the device can deliver therapy at multiple frequencies (eg, with a broadband therapy transducer), and the frequency between TCPs can be modulated using frequencies. As discussed for FIG. 18, the spacing of the strips is determined at the time of manufacture because this is caused by ceramic polarization. The lower frequency and deeper depth produce a wider separation between the simultaneously generated TCPs (yz plane). Fig. 4a shows a three-dimensional matrix of TCPs with these total different degrees of separation. As the frequency of shallower depths increases and the treatment depth decreases, the distance between the resulting TCPs decreases. Figure 28 shows the projection of delivery along mechanical motion (x axis) and depth (z axis). This clearly shows the deviation of the middle layer of TCP from shallow and deep treatments, even if the pitch is the same. Figure 29 shows the projection of the delivery along the direction of beam splitting (y-axis) and depth (z-axis). This projection shows that as the depth of treatment increases, the interval between TCPs gradually becomes larger, mainly due to changes in depth and frequency during treatment.
In one embodiment, as shown in FIG. 29, different intervals can be generated by changing the frequency and depth of focus. For example, Equation 14 is:
s = (2 k x z f l) / (2 p)
Where s is the interval between two simultaneous focal points at the same depth. This equation shows that focal separation is a function of depth of focus (zf) and frequency (because λ is the speed of sound divided by frequency). It is assumed that the same frequency and spatial frequency on the band are used. The table summarizes the separation of different focal points with a separation of 1.5 mm.
f 1_____ f 2_____
A 1 , 1 / θ 1 , 1 A 1 , 2 / θ 1 , 2
A 2 , 1 / θ 2 , 1 A 2 , 2 / θ 2 , 2
A 3 , 1 / θ 3 , 1 A 3 , 2 / θ 3 , 2
A 4 , 1 / θ 4 , 1 A 4 , 2 / θ 4 , 2
Where X 1 = excitation (A, θ) = A 1,1 sin (w 1 t- θ 1,1 ) A 1,2 sin (w 2 t- θ 1,2 ) to produce two at different distances At the same time focus.
在各種實施例中，當在材料上施加足夠的DC偏壓時，電致伸縮器表現出壓電行為。在一個實施例中，壓電行為的強度與聲學靈敏度成比例。在一個實施例中，電致伸縮材料在製造過程中與治療碗一起使用。在一個實施例中，在製造期間實現模式化和電極附接，但是在治療遞送期間完成電致伸縮器的極化。例如，在一個實施例中，發射孔徑可以是如圖37中所示的方波，或者通過修改高電壓值來遮蔽。圖30示出了同時多深度治療裝置的實施例，其配置成在1.5mm、3.0mm和4.5mm的深度處產生TCP，其中環形陣列與能夠在不同深度處同時產生多對的電致伸縮器耦合。在一個實施例中，電致伸縮器改變空間頻率（例如圖37中的一個實施例中所示）以提供產生治療線（例如圖34中的一個實施例中所示）。在一個實施例中，電致伸縮器產生治療線而不採用機械運動機構。在一個實施例中，電致伸縮器產生垂直於機械運動機構的運動的線。因此，在各種實施例中，多維治療可以在各種間隔、線、平面或三維空間中產生一個、兩個或更多個治療聚焦區域。在一些實施例中，電致伸縮器導致壓電換能器的晶格中的離子在暴露於外部電場時發生位移。在各種實施例中，圖17-29具有固定極化模式以產生兩個同時產生的TCP之間的分離距離。這是因為極化模式是在製造過程中在壓電陶瓷中產生的。條帶之間的間隔確定TCP之間的間隔。條帶之間的距離越大，TCP越接近。在一些實施例中，在極化完成之後不能改變條帶之間的距離。在一個實施例中，如圖30-33中所示，電絕緣材料不涉及極化，而是使用電致伸縮器在裝置操作期間施加直流（DC）電壓以表現出可以用於改善裝置性能的壓電行為。圖Sa示出了陶瓷碗的正面和背面（例如，凹側和凸側），其類似於圖17中所示的實施例。在一個實施例中，環形模式在換能器的背面（例如，凸側）上。與圖17中的實施例相比，前側（患者側，例如，凹側）略有不同，例如，條帶看起來以更精細的節距產生。其次，陶瓷不是極化的，而是來自每個單獨條帶的連接被連接到獨立的電子器件組，從而在條帶上施加電壓以產生適當的模式，所述模式產生TCP之間的分離距離。在一個實施例中，電壓以高空間頻率變化，導致在TCP之間產生更大的分離距離。電子器件允許改變該模式，使得TCP之間的距離也可以改變。結果是可以通過該幅度調製產生的同時TCP的集合。沒有必要在每個條帶上施加負電壓或正電壓。在一些實施例中，將條帶短接到地可以防止或減少聲激勵。圖31示出了可以三維產生的TCP分佈類型的實施例。在實施例中，在每個深度處產生五個TCP，其用條帶上的三個不同的DC幅度調製模式來實現。再次，基於運動機構從左向右或從右向左的運動，調製模式和環的聚焦，依序可以在深度279內或在每個深度處變化。使用的順序基於表皮和真皮以及任何其他組織層的安全耐受性，以及盡可能快地遞送TCP的目標。圖32示出了沿著機械運動（x軸）和深度（z軸）的遞送的投影。圖33示出了沿著波束***的方向（y軸）和深度（z軸）的遞送的投影。該投影示出了在該平面中產生的五個TCP。同時產生兩對TCP，其中一對與傳統換能器類似地一次產生。在各種實施例中，對於圖21-29的實施例討論的技術適用於電致伸縮器設計。In various embodiments, when a sufficient DC bias is applied to the material, the electrostrictor exhibits piezoelectric behavior. In one embodiment, the intensity of the piezoelectric behavior is proportional to the acoustic sensitivity. In one embodiment, the electrostrictive material is used with the treatment bowl during the manufacturing process. In one embodiment, patterning and electrode attachment are achieved during manufacturing, but the polarization of the electrostrictor is completed during treatment delivery. For example, in one embodiment, the transmission aperture may be a square wave as shown in FIG. 37, or masked by modifying the high voltage value. FIG. 30 shows an embodiment of a simultaneous multi-depth treatment device configured to generate TCP at depths of 1.5 mm, 3.0 mm, and 4.5 mm, wherein the ring array and the electrostrictor capable of simultaneously generating multiple pairs at different depth coupling. In one embodiment, the electrostrictor changes the spatial frequency (such as shown in one embodiment in FIG. 37) to provide a treatment line (such as shown in one embodiment in FIG. 34). In one embodiment, the electrostrictor generates a treatment line without using a mechanical movement mechanism. In one embodiment, the electrostrictor generates a line perpendicular to the movement of the mechanical kinematic mechanism. Thus, in various embodiments, multi-dimensional therapy can generate one, two, or more therapeutic focus areas in various intervals, lines, planes, or three-dimensional spaces. In some embodiments, the electrostrictor causes ions in the lattice of the piezoelectric transducer to shift when exposed to an external electric field. In various embodiments, FIGS. 17-29 have a fixed polarization mode to produce a separation distance between two simultaneously generated TCPs. This is because the polarization mode is generated in the piezoelectric ceramics during the manufacturing process. The interval between stripes determines the interval between TCP. The greater the distance between the stripes, the closer TCP is. In some embodiments, the distance between the stripes cannot be changed after polarization is completed. In one embodiment, as shown in FIGS. 30-33, the electrically insulating material does not involve polarization, but uses an electrostrictor to apply a direct current (DC) voltage during operation of the device to show that it can be used to improve device performance Piezoelectric behavior. FIG. Sa shows the front and back sides of the ceramic bowl (for example, concave side and convex side), which is similar to the embodiment shown in FIG. 17. In one embodiment, the ring pattern is on the back side (eg, convex side) of the transducer. Compared with the embodiment in FIG. 17, the anterior side (patient side, for example, concave side) is slightly different, for example, the strips appear to be produced at a finer pitch. Secondly, the ceramic is not polarized, but the connection from each individual strip is connected to a separate group of electronics, thereby applying a voltage on the strip to produce the appropriate pattern, which produces a separation distance between TCP . In one embodiment, the voltage changes at a high spatial frequency, resulting in a greater separation distance between TCPs. The electronics allow this mode to be changed so that the distance between TCPs can also be changed. The result is a set of simultaneous TCPs that can be generated by this amplitude modulation. There is no need to apply a negative or positive voltage to each strip. In some embodiments, shorting the strap to ground can prevent or reduce acoustic excitation. FIG. 31 shows an example of a TCP distribution type that can be generated in three dimensions. In an embodiment, five TCPs are generated at each depth, which is implemented with three different DC amplitude modulation modes on the stripe. Again, based on the movement of the motion mechanism from left to right or from right to left, the modulation mode and the focus of the ring can change sequentially within the depth 279 or at each depth. The order of use is based on the safety tolerance of the epidermis and dermis and any other tissue layers, and the goal of delivering TCP as quickly as possible. Figure 32 shows the projection of delivery along mechanical motion (x-axis) and depth (z-axis). Figure 33 shows the projection of the delivery along the direction of beam splitting (y-axis) and depth (z-axis). This projection shows the five TCPs generated in this plane. Two pairs of TCP are generated at the same time, one of which is generated at a time similar to the conventional transducer. In various embodiments, the techniques discussed for the embodiments of FIGS. 21-29 are applicable to electrostrictor designs.
圖34-36示出了同時多深度治療裝置的實施例，其配置成在1.5mm、3.0mm和4.5mm的深度處產生TCP，其中環形陣列與同時治療換能器耦合使得能夠在不同深度處同時產生兩條線。在一個實施例中，使用具有足夠條帶的電致伸縮器的優點是如果模式快速改變則產生熱治療線的能力。圖34示出了實施例，示出了在僅一個深度處使用電致伸縮器模式的多個空間頻率產生的三維TCP線。取決於條帶上的模式變化的速率，可以改變該加熱以產生微凝固線或高溫線，其是用於細胞凋亡的組織。圖35示出了到x-z平面的投影，其考慮了五條線。圖36示出了到y-z平面的投影，其示出了在特定深度處沿著y軸的加熱線。34-36 show an embodiment of a simultaneous multi-depth treatment device configured to generate TCP at depths of 1.5 mm, 3.0 mm, and 4.5 mm, wherein the ring array is coupled with simultaneous treatment transducers to enable different depth Two lines are generated at the same time. In one embodiment, the advantage of using an electrostrictor with sufficient straps is the ability to generate a thermal treatment line if the mode changes rapidly. FIG. 34 shows an embodiment showing a three-dimensional TCP line generated using multiple spatial frequencies of electrostrictor mode at only one depth. Depending on the rate of mode change on the strip, this heating can be changed to produce a microcoagulation line or a high temperature line, which is a tissue used for apoptosis. Fig. 35 shows a projection to the x-z plane, which considers five lines. Fig. 36 shows a projection onto the y-z plane, which shows the heating line along the y-axis at a specific depth.
在一個實施例中，圖37示出了當條帶具有細節距時可以生成的不同模式。在圖37中，X軸表示橫跨換能器的距離。Y軸表示橫跨換能器的位置處的DC幅度。在各種實施例中，橫跨換能器施加的各種DC信號可以導致焦點之間的不同間隔。在一個實施例中，細節距與試圖實現的***距離、操作頻率、焦深有關。在各種實施例中，細節距在0.1mm至0.05mm之間（例如，100微米至50微米，包括90、80、70、60微米及其中的任何值）。該圖示出了沿著y軸可能產生微凝固點的不同間隔的幅度調製。儘管該圖涵蓋了2倍的因數，但是可以具有在所示的倍數之間的其他調製模式。調製模式不必是1x模式的整數。在各種實施例中，偶數、奇數和零模式是可能的。最後，電致伸縮器方法還提供調製幅度模式的可能性，因為極化是DC偏壓的強函數。In one embodiment, FIG. 37 shows different patterns that can be generated when a strip has a fine pitch. In FIG. 37, the X axis represents the distance across the transducer. The Y axis represents the DC amplitude at the position across the transducer. In various embodiments, various DC signals applied across the transducer may result in different spacing between focal points. In one embodiment, the detail distance is related to the split distance, operating frequency, and depth of focus that are attempted to be achieved. In various embodiments, the detail distance is between 0.1 mm and 0.05 mm (eg, 100 microns to 50 microns, including 90, 80, 70, 60 microns, and any value thereof). The figure shows differently spaced amplitude modulation along the y axis that may produce micro-freezing points. Although the figure covers a factor of 2 times, there may be other modulation modes between the multiples shown. The modulation mode does not have to be an integer of 1x mode. In various embodiments, even, odd, and zero patterns are possible. Finally, the electrostrictor method also offers the possibility of modulating the amplitude mode, because the polarization is a strong function of DC bias.
配置成在不同深度處產生多個TCP的同時多深度治療裝置的實施例的各種優點包括在多個深度處產生同時TCP。在一個實施例中，優點是消除了多個換能器，由此減少了操作者的換能器交換。在一個實施例中，優點是更快的治療時間。在一個實施例中，優點是更少的按鈕按壓遞送相同數量的線。在一個實施例中，優點是調製同時傳送的TCP之間的距離。在一個實施例中，優點是沿著機械運動線在每個深度處保持TCP的節距分離。在一個實施例中，優點是避免在多個深度處的脈衝堆疊。在一個實施例中，優點是能夠產生更大的凝血和細胞凋亡區域。在一個實施例中，優點是能夠沿著三個維度遞送微凝固線。在一個實施例中，使用電致伸縮器的優點包括用一個換能器放置在患者的身體上產生兩個以上線。在一個實施例中，使用電致伸縮器的優點是調製同時遞送的TCP之間的距離。在一個實施例中，優點是調製從同時治療調製模式減弱空間高頻諧波的能力。在一個實施例中，使用電致伸縮器的優點提供了向調製模式添加零點的可能性。Various advantages of embodiments of a simultaneous multi-depth treatment device configured to generate multiple TCPs at different depths include generating simultaneous TCPs at multiple depths. In one embodiment, the advantage is that multiple transducers are eliminated, thereby reducing the operator's transducer exchange. In one embodiment, the advantage is faster treatment time. In one embodiment, the advantage is that fewer button presses deliver the same number of lines. In one embodiment, the advantage is to modulate the distance between simultaneously transmitted TCPs. In one embodiment, the advantage is that the pitch of the TCP is kept separate at each depth along the mechanical motion line. In one embodiment, the advantage is to avoid pulse stacking at multiple depths. In one embodiment, the advantage is the ability to produce larger areas of coagulation and apoptosis. In one embodiment, the advantage is the ability to deliver microcoagulation lines along three dimensions. In one embodiment, the advantages of using an electrostrictor include placing more than two wires with one transducer placed on the patient's body. In one embodiment, the advantage of using an electrostrictor is to modulate the distance between TCPs delivered simultaneously. In one embodiment, the advantage is the ability of modulation to attenuate spatial high frequency harmonics from the simultaneous treatment modulation mode. In one embodiment, the advantages of using electrostrictors provide the possibility of adding zeros to the modulation pattern.
本文描述的一些實施例和示例是例子，並不旨在限制描述這些發明的組合物和方法的全部範圍。一些實施例，材料、組合物和方法的等同變化、修改和變動可以在本發明的範圍內進行，具有基本相似的結果。Some of the embodiments and examples described herein are examples, and are not intended to limit the full scope of the compositions and methods that describe these inventions. In some embodiments, equivalent changes, modifications, and variations in materials, compositions, and methods can be made within the scope of the present invention, with substantially similar results.
儘管本發明易於進行各種修改和替代形式，但是其具體示例已在附圖中示出並在本文中詳細描述。然而，應當理解的是，本發明不限於所公開的特定形式或方法，相反地，本發明將涵蓋落入所述的各種實施例和所附申請專利範圍的精神和範圍內的所有修改、等同物和替代物。本文公開的任何方法不需要按照所述順序執行。本文公開的方法包括從業者採取的某些動作；然而，它們也可以明確地或暗示地包括這些行為的任何第三方指示。例如，諸如“將換能器模組與超音探頭耦合”的動作包括“指示換能器模組與超音探頭的耦合”。本文公開的範圍還包括任何和所有重疊、子範圍及其組合。諸如“至多”、“至少”、“大於”、“小於”、“在......之間”等用語包括所述的數字。在諸如“約”或“大約”的術語之後的數字包括所述的數字。例如，“約25mm”包括“25mm”。Although the present invention is susceptible to various modifications and alternative forms, specific examples thereof have been shown in the drawings and described in detail herein. However, it should be understood that the present invention is not limited to the specific forms or methods disclosed. On the contrary, the present invention will cover all modifications, equivalents that fall within the spirit and scope of the various embodiments described and the scope of the appended patent applications And substitutes. Any methods disclosed herein need not be performed in the order described. The methods disclosed herein include certain actions taken by practitioners; however, they may also explicitly or implicitly include any third-party instructions for these actions. For example, actions such as "coupling the transducer module and the ultrasound probe" include "instructing the coupling of the transducer module and the ultrasound probe." The ranges disclosed herein also include any and all overlaps, subranges, and combinations thereof. Terms such as "at most", "at least", "greater than", "less than", "between", etc. include the numbers described. The numbers after terms such as "about" or "approximately" include the stated numbers. For example, "about 25mm" includes "25mm".
10‧‧‧感興趣區域10‧‧‧interest area
20‧‧‧超音系統/系統 20‧‧‧ Ultrasonic system / system
50‧‧‧超音能量 50‧‧‧Supersonic energy
100‧‧‧手持棒狀器 100‧‧‧Handheld stick
100'‧‧‧手持棒狀器 100'‧‧‧Handheld stick
100''‧‧‧手持棒狀器 100''‧‧‧hand stick
130‧‧‧介面 130‧‧‧Interface
140‧‧‧控制器或開關 140‧‧‧Controller or switch
145‧‧‧連接器 145‧‧‧Connector
150‧‧‧成像控制器/控制器或開關 150‧‧‧Imaging controller / controller or switch
160‧‧‧熱處理控制器/控制器或開關 160‧‧‧heat treatment controller / controller or switch
200‧‧‧模組 200‧‧‧Module
200'‧‧‧模組 200'‧‧‧Module
200''‧‧‧模組 200''‧‧‧Module
230‧‧‧聲學透明構件 230‧‧‧ Acoustic transparent component
235‧‧‧介面引導件 235‧‧‧ interface guide
254‧‧‧治療區域 254‧‧‧Treatment area
270‧‧‧偏移距離 270‧‧‧Offset distance
278‧‧‧焦深 278‧‧‧Depth of focus
279‧‧‧組織深度/深度 279‧‧‧Depth of organization / depth
280‧‧‧超音換能器/換能器 280‧‧‧Supersonic transducer / transducer
281‧‧‧治療通道/治療通道環形換能器元件/元件 281‧‧‧Treatment Channel / Treatment Channel Ring Transducer Element / Element
282‧‧‧凸側 282‧‧‧Convex side
283‧‧‧凹側 283‧‧‧Concave side
285‧‧‧成像換能器 285‧‧‧Imaging transducer
290‧‧‧方向/第一方向/箭頭 290‧‧‧direction / first direction / arrow
291‧‧‧箭頭 291‧‧‧arrow
295‧‧‧間隔 295‧‧‧Interval
300‧‧‧控制器/控制台/控制模組 300‧‧‧Controller / Control Panel / Control Module
300'‧‧‧控制器 300'‧‧‧Controller
300''‧‧‧控制器 300''‧‧‧Controller
301‧‧‧推車 301‧‧‧cart
302‧‧‧隔室 302‧‧‧compartment
310‧‧‧圖形顯示器/顯示器/圖形使用者介面/圖形介面 310‧‧‧Graphic display / display / graphic user interface / graphic interface
320‧‧‧存取密鑰 320‧‧‧Access key
400‧‧‧運動機構 400‧‧‧Sports agency
401‧‧‧導螺杆 401‧‧‧Lead screw
402‧‧‧編碼器 402‧‧‧Encoder
403‧‧‧電機 403‧‧‧Motor
500‧‧‧受試者 500‧‧‧ subjects
501‧‧‧皮膚表面/表面/皮膚 501‧‧‧Skin surface / surface / skin
502‧‧‧表皮層 502‧‧‧epidermal layer
503‧‧‧真皮層 503‧‧‧Dermis layer
504‧‧‧下皮 504‧‧‧skin
505‧‧‧脂肪層 505‧‧‧Fat layer
507‧‧‧淺表肌肉腱膜系統/SMAS/SMAS層 507‧‧‧Superficial muscle aponeurotic system / SMAS / SMAS layer
509‧‧‧肌肉層 509‧‧‧muscle layer
525‧‧‧治療區域 525‧‧‧Treatment area
550‧‧‧熱凝固點或區域（TCP） 550‧‧‧ Thermal freezing point or area (TCP)
D1‧‧‧深度 D1‧‧‧Depth
D2‧‧‧深度 D2‧‧‧Depth
D3‧‧‧深度 D3‧‧‧Depth
Tx0‧‧‧環 Tx0‧‧‧ring
Tx1‧‧‧環 Tx1‧‧‧ring
Tx2‧‧‧環 Tx2‧‧‧ring
Tx3‧‧‧環 Tx3‧‧‧ring
Tx4‧‧‧環 Tx4‧‧‧ring
Tx5‧‧‧環 Tx5‧‧‧ring
Tx6‧‧‧環 Tx6‧‧‧ring
Tx7‧‧‧環 Tx7‧‧‧ring
本文描述的附圖僅用於說明目的，並不旨在以任何方式限制本公開的範圍。從詳細描述和附圖將更全面地理解本發明的實施例，其中：The drawings described herein are for illustrative purposes only and are not intended to limit the scope of the present disclosure in any way. The embodiments of the present invention will be more fully understood from the detailed description and the drawings, in which:
圖1A是根據本發明的各種實施例的超音系統的示意圖。FIG. 1A is a schematic diagram of a supersonic system according to various embodiments of the present invention.
圖1B是根據本發明的各種實施例的超音系統的示意圖。FIG. 1B is a schematic diagram of a supersonic system according to various embodiments of the present invention.
圖1C是根據本發明的各種實施例的超音系統的示意圖。FIG. 1C is a schematic diagram of a supersonic system according to various embodiments of the present invention.
圖2是根據本發明的各種實施例的耦合到感興趣區域的超音系統的示意圖。2 is a schematic diagram of a supersonic system coupled to a region of interest according to various embodiments of the present invention.
圖3是根據本發明的各種實施例的換能器的一部分的示意圖。3 is a schematic diagram of a portion of a transducer according to various embodiments of the invention.
圖4是根據本發明的各種實施例的超音系統的部分剖視側視圖。FIG. 4 is a partially cut-away side view of a supersonic system according to various embodiments of the present invention.
圖5是示出根據本發明的各種實施例的具有不同空間頻率的孔徑的焦點分離的表。FIG. 5 is a table showing focus separation with apertures having different spatial frequencies according to various embodiments of the present invention.
圖6是示出根據本發明的各種實施例的具有不同孔徑空間頻率的孔徑的焦點分離的曲線圖。6 is a graph illustrating the separation of focal points of apertures having different aperture spatial frequencies according to various embodiments of the present invention.
圖7是示出根據本發明的各種實施例的具有不同孔徑空間頻率的孔徑的焦點分離的曲線圖。7 is a graph illustrating the separation of focal points of apertures having different aperture spatial frequencies according to various embodiments of the present invention.
圖8是根據本發明的各種實施例的具有空間頻率的孔徑極化的示意圖，所述空間頻率可以通過激勵通道修改。8 is a schematic diagram of aperture polarization with spatial frequencies according to various embodiments of the present invention, which can be modified by an excitation channel.
圖9是根據本發明的各種實施例的具有空間頻率的極化陶瓷的示意圖，所述空間頻率可以通過激勵覆蓋陶瓷的兩個極化區域的通道修改。9 is a schematic diagram of a polarized ceramic having a spatial frequency according to various embodiments of the present invention, which can be modified by exciting a channel covering two polarized regions of the ceramic.
圖10是具有成像換能器的陣列換能器的實施例的示意圖。Figure 10 is a schematic diagram of an embodiment of an array transducer with an imaging transducer.
圖11是根據本發明的各種實施例的從凸側、側視橫截面和凹側觀察的換能器的示意圖。11 is a schematic diagram of a transducer viewed from a convex side, a side cross-sectional view, and a concave side according to various embodiments of the present invention.
圖12是根據本發明的各種實施例的從凸側、側視橫截面和凹側觀察的換能器的示意圖。12 is a schematic diagram of a transducer viewed from a convex side, a side cross-sectional view, and a concave side according to various embodiments of the present invention.
圖13是根據本發明的各種實施例的從凸側、側視橫截面和凹側觀察的換能器的示意圖。13 is a schematic diagram of a transducer viewed from a convex side, a side cross-sectional view, and a concave side according to various embodiments of the present invention.
圖14是根據本發明的各種實施例的從凸側、側視橫截面和凹側觀察的換能器的示意圖。14 is a schematic diagram of a transducer viewed from a convex side, a side cross-sectional view, and a concave side according to various embodiments of the present invention.
圖15是根據本發明的各種實施例的從凸側、側視橫截面和凹側觀察的換能器的示意圖。15 is a schematic diagram of a transducer viewed from a convex side, a side cross-sectional view, and a concave side according to various embodiments of the present invention.
圖16是根據本發明的各種實施例的從凸側、側視橫截面和凹側觀察的換能器的示意圖。16 is a schematic diagram of a transducer viewed from a convex side, a side cross-sectional view, and a concave side according to various embodiments of the present invention.
圖17是根據本發明的各種實施例的從凸側和凹側觀察的換能器的示意圖。FIG. 17 is a schematic diagram of a transducer viewed from a convex side and a concave side according to various embodiments of the present invention.
圖18是根據本發明的各種實施例的由換能器產生的各種深度處的多個熱凝固區域的示意圖。18 is a schematic diagram of multiple thermal solidification regions at various depths produced by a transducer according to various embodiments of the invention.
圖19是根據圖18的由換能器產生的各種深度處的多個熱凝固區域的x-z平面的示意圖。FIG. 19 is a schematic diagram of the x-z plane of multiple thermal solidification regions at various depths generated by the transducer according to FIG. 18.
圖20是根據圖18的由換能器產生的各種深度處的多個熱凝固區域的y-z平面的示意圖。20 is a schematic diagram of the y-z plane of multiple thermal solidification regions at various depths generated by the transducer according to FIG. 18.
圖21是根據本發明的各種實施例的由換能器產生的各種不同深度處的多個熱凝固區域的示意圖。21 is a schematic diagram of multiple thermal solidification regions at various depths produced by a transducer according to various embodiments of the invention.
圖22是根據圖21的由換能器產生的各種深度處的多個熱凝固區域的x-z平面的示意圖。22 is a schematic diagram of the x-z plane of multiple thermal solidification regions at various depths generated by the transducer according to FIG. 21.
圖23是根據圖21的由換能器產生的各種深度處的多個熱凝固區域的y-z平面的示意圖。23 is a schematic diagram of the y-z plane of multiple thermal solidification regions at various depths generated by the transducer according to FIG. 21.
圖24是根據本發明的各種實施例的由換能器產生的各種深度處的多個熱凝固區域的示意圖。24 is a schematic diagram of multiple thermal solidification regions at various depths produced by a transducer according to various embodiments of the invention.
圖25是根據圖24的由換能器產生的各種深度處的多個熱凝固區域的x-z平面的示意圖。25 is a schematic diagram of the x-z plane of multiple thermal solidification regions at various depths generated by the transducer according to FIG. 24.
圖26是根據圖24的由換能器產生的各種深度處的多個熱凝固區域的y-z平面的示意圖。26 is a schematic diagram of the y-z plane of multiple thermal solidification regions at various depths generated by the transducer according to FIG. 24.
圖27是根據本發明的各種實施例的由換能器產生的各種深度處的多個熱凝固區域的示意圖。FIG. 27 is a schematic diagram of multiple thermal solidification regions at various depths produced by a transducer according to various embodiments of the invention.
圖28是根據圖27的由換能器產生的各種深度處的多個熱凝固區域的x-z平面的示意圖。28 is a schematic diagram of the x-z plane of multiple thermal solidification regions at various depths generated by the transducer according to FIG. 27.
圖29是根據圖27的由換能器產生的各種深度處的多個熱凝固區域的y-z平面的示意圖。29 is a schematic diagram of the y-z plane of multiple thermal solidification regions at various depths generated by the transducer according to FIG. 27.
圖30是根據本發明的各種實施例的從凸側和凹側觀察的換能器的示意圖。30 is a schematic diagram of a transducer viewed from the convex side and the concave side according to various embodiments of the present invention.
圖31是根據本發明的各種實施例的由換能器產生的各種深度處的多個熱凝固區域的示意圖。31 is a schematic diagram of multiple thermal solidification regions at various depths produced by a transducer according to various embodiments of the invention.
圖32是根據圖31的由換能器產生的各種深度處的多個熱凝固區域的x-z平面的示意圖。32 is a schematic diagram of the x-z plane of multiple thermal solidification regions at various depths generated by the transducer according to FIG. 31.
圖33是根據圖31的由換能器產生的各種深度處的多個熱凝固區域的y-z平面的示意圖。33 is a schematic diagram of the y-z plane of multiple thermal solidification regions at various depths generated by the transducer according to FIG. 31.
圖34是根據本發明的各種實施例的由換能器產生的各種深度處的多個熱凝固區域的示意圖。34 is a schematic diagram of multiple thermal solidification regions at various depths produced by a transducer according to various embodiments of the invention.
圖35是根據圖34的由換能器產生的各種深度處的多個熱凝固區域的x-z平面的示意圖。35 is a schematic diagram of the x-z plane of multiple thermal solidification regions at various depths generated by the transducer according to FIG. 34.
圖36是根據圖34的由換能器產生的各種深度處的多個熱凝固區域的y-z平面的示意圖。36 is a schematic diagram of the y-z plane of multiple thermal solidification regions at various depths generated by the transducer according to FIG. 34.
圖37是示出根據本發明的各種實施例的對應於由換能器產生的焦平面焦點的幅度和直流的曲線圖。FIG. 37 is a graph showing the magnitude and direct current of the focal plane focal point generated by the transducer according to various embodiments of the present invention.
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| US9827449B2 (en) | 2004-10-06 | 2017-11-28 | Guided Therapy Systems, L.L.C. | Systems for treating skin laxity |
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| US11724133B2 (en) | 2004-10-07 | 2023-08-15 | Guided Therapy Systems, Llc | Ultrasound probe for treatment of skin |
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