TW201613575A - Treatment of polybacterial infections - Google Patents
Treatment of polybacterial infectionsInfo
- Publication number
- TW201613575A TW201613575A TW104119861A TW104119861A TW201613575A TW 201613575 A TW201613575 A TW 201613575A TW 104119861 A TW104119861 A TW 104119861A TW 104119861 A TW104119861 A TW 104119861A TW 201613575 A TW201613575 A TW 201613575A
- Authority
- TW
- Taiwan
- Prior art keywords
- polybacterial
- treatment
- infections
- antibody
- specifically binds
- Prior art date
Links
- 208000015181 infectious disease Diseases 0.000 title abstract 4
- 241000589517 Pseudomonas aeruginosa Species 0.000 abstract 2
- 241000894006 Bacteria Species 0.000 abstract 1
- 241000191967 Staphylococcus aureus Species 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 108010092231 staphylococcal alpha-toxin Proteins 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/40—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum bacterial
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
- C07K16/1214—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Pseudomonadaceae (F)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
- C07K16/1271—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Micrococcaceae (F), e.g. Staphylococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/515—Complete light chain, i.e. VL + CL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Dermatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Ophthalmology & Optometry (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462014506P | 2014-06-19 | 2014-06-19 | |
US62/014,506 | 2014-06-19 | ||
US201562140849P | 2015-03-31 | 2015-03-31 | |
US62/140,849 | 2015-03-31 |
Publications (2)
Publication Number | Publication Date |
---|---|
TW201613575A true TW201613575A (en) | 2016-04-16 |
TWI719938B TWI719938B (zh) | 2021-03-01 |
Family
ID=54936121
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TW104119861A TWI719938B (zh) | 2014-06-19 | 2015-06-18 | 多重細菌感染之治療 |
Country Status (10)
Country | Link |
---|---|
US (1) | US11168132B2 (zh) |
EP (1) | EP3157565B1 (zh) |
JP (2) | JP6845016B2 (zh) |
KR (1) | KR102549870B1 (zh) |
CN (1) | CN106456767B (zh) |
AU (1) | AU2015276938B2 (zh) |
CA (1) | CA2952278A1 (zh) |
SG (2) | SG10201811361XA (zh) |
TW (1) | TWI719938B (zh) |
WO (1) | WO2015196011A1 (zh) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012170807A2 (en) | 2011-06-10 | 2012-12-13 | Medimmune, Llc | Anti-pseudomonas psl binding molecules and uses thereof |
SI2776065T1 (sl) | 2011-11-07 | 2020-10-30 | Medimmune Limited | Kombinacijske terapije z uporabo molekul, ki vežejo anti-Pseudomonas Psl in PcrV |
SG11201503231YA (en) | 2012-11-06 | 2015-05-28 | Medimmune Llc | METHODS OF TREATING <i>S. AUREUS</i>-ASSOCIATED DISEASES |
SG11201503232TA (en) * | 2012-11-06 | 2015-05-28 | Medimmune Llc | Antibodies to s. aureus surface determinants |
JP7110095B2 (ja) | 2015-11-30 | 2022-08-01 | メドイミューン・リミテッド | 院内肺炎を予防または治療する方法 |
US20190153076A1 (en) * | 2016-05-05 | 2019-05-23 | The Trustees Of The University Of Pennsylvania | DNA Antibody Constructs for Use against Pseudomonas Aeuruginosa |
TW202311284A (zh) | 2017-01-03 | 2023-03-16 | 美商再生元醫藥公司 | 抗金黃色葡萄球菌溶血素a毒素之人類抗體 |
CA3107463A1 (en) | 2018-07-24 | 2020-01-30 | Medimmune, Llc | Antibody directed against s. aureus clumping factor a (clfa) |
TW202028232A (zh) | 2018-10-09 | 2020-08-01 | 美商麥迪紐有限責任公司 | 針對金黃色葡萄球菌白血球毒素的抗體 |
TW202035443A (zh) | 2018-10-09 | 2020-10-01 | 美商麥迪紐有限責任公司 | 抗金黃色葡萄球菌抗體的組合 |
GB201816554D0 (en) | 2018-10-10 | 2018-11-28 | Centauri Therapeutics Ltd | Novel compounds and therapeutic uses thereof |
GB201816553D0 (en) | 2018-10-10 | 2018-11-28 | Centauri Therapeutics Ltd | Novel compounds and therapeutic uses thereof |
WO2021015237A1 (ja) * | 2019-07-24 | 2021-01-28 | 国立研究開発法人科学技術振興機構 | 抗体酵素の革新的製造技術 |
FR3114970B1 (fr) | 2020-10-08 | 2023-06-30 | Univ Tours | Combinaison d’anticorps inhalés avec des agents immunomodulateurs pour le traitement ou la prévention d’inféctions respiratoires |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2655133C (en) | 2006-06-12 | 2018-03-20 | Nabi Biopharmaceuticals | Use of alpha-toxin for treating and preventing staphylococcus infections |
US8642039B2 (en) * | 2009-12-22 | 2014-02-04 | Kalobios Pharmaceuticals, Inc. | Method of treating a staphylococcus infection in a patient having a low-level pathogenic Pseudomonas aeruginosa infection |
CA2826566C (en) * | 2011-02-08 | 2022-09-13 | Medimmune, Llc | Antibodies that specifically bind staphylococcus aureus alpha toxin and methods of use |
SI2776065T1 (sl) | 2011-11-07 | 2020-10-30 | Medimmune Limited | Kombinacijske terapije z uporabo molekul, ki vežejo anti-Pseudomonas Psl in PcrV |
SG11201503231YA (en) | 2012-11-06 | 2015-05-28 | Medimmune Llc | METHODS OF TREATING <i>S. AUREUS</i>-ASSOCIATED DISEASES |
JP2015535005A (ja) * | 2012-11-06 | 2015-12-07 | メディミューン,エルエルシー | 抗シュードモナス属(Pseudomonas)PslおよびPcrV結合分子を用いた併用治療 |
SG11201503232TA (en) | 2012-11-06 | 2015-05-28 | Medimmune Llc | Antibodies to s. aureus surface determinants |
US20190077851A1 (en) | 2015-10-30 | 2019-03-14 | Bruno Francois | Methods of using anti-alpha toxin antibody |
-
2015
- 2015-06-18 TW TW104119861A patent/TWI719938B/zh active
- 2015-06-19 SG SG10201811361XA patent/SG10201811361XA/en unknown
- 2015-06-19 JP JP2016573926A patent/JP6845016B2/ja active Active
- 2015-06-19 EP EP15809174.4A patent/EP3157565B1/en active Active
- 2015-06-19 KR KR1020167034742A patent/KR102549870B1/ko active IP Right Grant
- 2015-06-19 US US15/319,958 patent/US11168132B2/en active Active
- 2015-06-19 CA CA2952278A patent/CA2952278A1/en active Pending
- 2015-06-19 AU AU2015276938A patent/AU2015276938B2/en active Active
- 2015-06-19 CN CN201580032548.7A patent/CN106456767B/zh active Active
- 2015-06-19 WO PCT/US2015/036576 patent/WO2015196011A1/en active Application Filing
- 2015-06-19 SG SG11201609652RA patent/SG11201609652RA/en unknown
-
2020
- 2020-12-18 JP JP2020209896A patent/JP2021063090A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
WO2015196011A1 (en) | 2015-12-23 |
SG11201609652RA (en) | 2016-12-29 |
JP2017519768A (ja) | 2017-07-20 |
KR20170015329A (ko) | 2017-02-08 |
EP3157565B1 (en) | 2024-04-24 |
EP3157565A4 (en) | 2018-03-21 |
KR102549870B1 (ko) | 2023-06-29 |
SG10201811361XA (en) | 2019-01-30 |
AU2015276938A1 (en) | 2017-01-05 |
CN106456767A (zh) | 2017-02-22 |
US20170129943A1 (en) | 2017-05-11 |
EP3157565A1 (en) | 2017-04-26 |
US11168132B2 (en) | 2021-11-09 |
JP6845016B2 (ja) | 2021-03-17 |
JP2021063090A (ja) | 2021-04-22 |
AU2015276938B2 (en) | 2020-11-19 |
TWI719938B (zh) | 2021-03-01 |
CN106456767B (zh) | 2021-07-09 |
CA2952278A1 (en) | 2015-12-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
TW201613575A (en) | Treatment of polybacterial infections | |
PH12018501429A1 (en) | Compositions and methods for treating and preventing staphylococcus aureus infections | |
PH12016501577A1 (en) | Monobactam organic compounds for the treatment of bacterial infections | |
EA201991157A1 (ru) | Доставка белков на основе бактерий, аттенуированных по вирулентности | |
WO2017075188A3 (en) | Methods of using anti-alpha toxin antibody | |
NZ713621A (en) | Compounds and methods of treating infections | |
MX2019007784A (es) | Anticuerpos humanos a la toxina hemolisina a de s. aureus. | |
NZ713615A (en) | Methods for treating bacterial infections | |
MX363678B (es) | Terapia de combinación que comprende oxazolidinona-quinolonas para usarse en el tratamiento de infecciones bacterianas. | |
BR112017003571A2 (pt) | terapia combinada | |
MX2015010191A (es) | Metodos para tratar infecciones microbianas, incluyendo mastitis. | |
WO2016142445A3 (en) | Combination of bactericidal agent with a lysosomotropic alkalinising agent for the treatment of a bacterial infection | |
ZA202002093B (en) | Antibacterial compounds | |
PH12017500887A1 (en) | Method for treating, preventing, or reducing the risk of skin infection | |
WO2014152437A3 (en) | Methods of use for an antimicrobial peptide | |
WO2015126930A3 (en) | Booster drug therapy for mycobacterium infections | |
CL2019001918A1 (es) | Métodos para tratar infecciones bacterianas. | |
WO2019025803A3 (en) | ANTIMICROBIAL COMPOSITION | |
BR112017022796A2 (pt) | composições antibacterianas e métodos | |
WO2015100447A3 (en) | Ultra-low dose lysostaphin for treating mrsa | |
PH12016502547A1 (en) | Methods for treating infections | |
EA201591267A1 (ru) | Рифаксимин для применения в лечении вагинальных инфекций | |
AU2017338319A8 (en) | Vasoconstrictive and antibacterial combination treatment for rosacea | |
EA202090453A3 (ru) | Антитела к cd40 | |
UA97018U (uk) | Спосіб лікування урогенітальних інфекцій у жінок з порушенням репродуктивної функції |