TW201536255A - Portable analytical device and system - Google Patents
Portable analytical device and system Download PDFInfo
- Publication number
- TW201536255A TW201536255A TW103110711A TW103110711A TW201536255A TW 201536255 A TW201536255 A TW 201536255A TW 103110711 A TW103110711 A TW 103110711A TW 103110711 A TW103110711 A TW 103110711A TW 201536255 A TW201536255 A TW 201536255A
- Authority
- TW
- Taiwan
- Prior art keywords
- portable
- optical unit
- computing device
- handheld computing
- sample
- Prior art date
Links
Landscapes
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Abstract
Description
本申請是關於用於量測樣本的光學性質的攜帶型分析裝置以及系統。 The present application relates to a portable analytical device and system for measuring the optical properties of a sample.
現今存在多種可用於量測樣本的性質的儀器。舉例而言，血氧定量計(oximeter)用於量測人的組織毛細血管中的飽和血紅蛋白的量，且折射計(refractometer)用於判定液體樣本中的溶解物質的濃度。 There are a variety of instruments available today for measuring the properties of a sample. For example, an oximeter is used to measure the amount of saturated hemoglobin in human tissue capillaries, and a refractometer is used to determine the concentration of dissolved substances in a liquid sample.
被視為「第五生命徵象」的SpO2表示血氧飽和度(blood oxygen saturation)。醫療專業人員可藉由監看患者的SpO2而偵測到血氧過少(hypoxemia)，亦即氧不足。一般認為介於約95%與100%之間的值是正常的；低於此含量則代表血氧過少。 SpO2, which is regarded as the "fifth vital sign", represents blood oxygen saturation. Medical professionals can detect hypoxemia, or oxygen deficiency, by monitoring the patient's SpO2. It is generally believed that a value between about 95% and 100% is normal; below this level represents hypoxemia.
脈動式測氧法(Pulse oximetry)為用於量測患者的SpO2的技術，可自患者之動脈血氧飽和度或SaO2(其為患者的血液中存在之含氧動脈血紅蛋白的百分比)獲得此參數。 Pulse oximetry is a technique for measuring SpO2 in a patient. This parameter can be obtained from the patient's arterial oxygen saturation or SaO2, which is the percentage of oxygenated arterial hemoglobin present in the patient's blood. .
大體而言，官能血紅蛋白分子可與多達四個氧分子結合而得到「含氧」血紅蛋白(HbO2)，其中與小於四個氧分子結合的血紅蛋白分子被分類為「還原」血紅蛋白(Hb)。已知的脈動式 血氧定量計使用假定血液中僅存在HbO2以及Hb的演算法，並根據等式(1)自含氧血紅蛋白與血紅蛋白總量(含氧「HbO2」以及還原「Hb」兩者)之比量測SpO2：SpO2=HbO2/(HbO2+Hb) (1) In general, a functional hemoglobin molecule can be combined with up to four oxygen molecules to produce "oxygenated" hemoglobin (HbO2), wherein a hemoglobin molecule that binds to less than four oxygen molecules is classified as "reduced" hemoglobin (Hb). Known pulsation The oximeter uses an algorithm that assumes that only HbO2 and Hb are present in the blood, and measures the ratio of the ratio of oxygenated hemoglobin to total hemoglobin (oxygen "HbO2" and reduced "Hb") according to equation (1). SpO2: SpO2=HbO2/(HbO2+Hb) (1)
目前可分別在不同的吸收光譜(例如，可見紅色光區以及紅外線區)中以光學方式量測HbO2以及Hb含量。已知的脈動式血氧定量計帶有在可見紅色光(約660nm之λ)以及紅外線(介於900nm與950nm之間的λ)光譜區中輻射的光源，且亦帶有用於量測透射通過患者之脈動血液的在每一所提及波長處的輻射之一部分的光偵測器。 The HbO2 and Hb contents can now be optically measured in different absorption spectra (for example, visible red and infrared regions). Known pulsation oximeters have a source of radiation that is radiated in the visible red light (λ of about 660 nm) and infrared (λ between 900 nm and 950 nm), and is also used for measuring transmission through A photodetector of the patient's pulsating blood at a portion of the radiation at each of the mentioned wavelengths.
舉例而言，在660nm下，Hb吸收的輻射約HbO2的十倍，而在925nm下，HbO2吸收的輻射約Hb的兩倍。偵測這些波長下之所透射的輻射可得到兩個時間相依的波形，分別被稱為光電血管容積圖(photoplethysmogram，PPG)。血氧定量計使用所述光電血管容積圖來求得上述等式(1)中所定義的SpO2值。 For example, at 660 nm, Hb absorbs about ten times more radiation than HbO2, while at 925 nm, HbO2 absorbs about twice as much as Hb. Detecting the transmitted radiation at these wavelengths yields two time-dependent waveforms, called photoplethysmogram (PPG). The oximeter uses the photovascular blood volume map to obtain the SpO2 value defined in the above equation (1).
具體而言，血氧定量計處理兩個PPG波形(一者為藉由紅色光波長所量測(RED(PPG))，且另一者為藉由紅外線波長所量測(IR(PPG)))，以判定時間相依AC信號以及時間獨立DC信號。AC分量主要由動脈血容量中的脈動改變所引起。AC分量之頻率等效於患者的心搏率(heart beat rate)。因此，可直接根據計數AC分量之頻率而估計心搏率。術語「AC信號」是指PPG波形之隨著時間相對快速地變化的一部分，例如，由患者之血液中的脈動引起的信號部分。另一方面，術語「DC信號」為PPG之隨著時間相對恆定的一部分，例如，由從諸如骨骼、皮膚之成分 的散射以及患者之血液的非脈動分量引起的信號部分。 Specifically, the oximeter processes two PPG waveforms (one measured by the wavelength of the red light (RED (PPG)) and the other measured by the infrared wavelength (IR (PPG)). To determine the time dependent AC signal and the time independent DC signal. The AC component is mainly caused by a pulsatile change in arterial blood volume. The frequency of the AC component is equivalent to the patient's heart beat rate. Therefore, the heart rate can be estimated directly from the frequency of counting the AC component. The term "AC signal" refers to a portion of the PPG waveform that changes relatively rapidly over time, for example, a portion of the signal caused by pulsations in the blood of the patient. On the other hand, the term "DC signal" is a relatively constant portion of the PPG over time, for example, from components such as bones and skin. The scattering and the portion of the signal caused by the non-pulsating component of the patient's blood.
通常藉由本領域中熟知的類比以及數位濾波技術來進行AC信號與DC信號之分離。在脈動式測氧法期間，通常使用下文之等式(2)自AC信號以及DC信號計算正規化「R值」：R=(Red(AC)/Red(DC))/(IR(AC)/IR(DC)) (2) The separation of the AC signal from the DC signal is typically performed by analogy and digital filtering techniques well known in the art. During the pulsating oxygen measurement method, the normalized "R value" is usually calculated from the AC signal and the DC signal using the following equation (2): R = (Red (AC) / Red (DC)) / (IR (AC) /IR(DC)) (2)
R表示Hb與HbO2之比，其使實際SpO2值(其在0% O2至100% O2的範圍內)等同於類似非線性等式的經驗關係。在高於約70% O2的情況下，此等式通常得到精度達到若干百分比的值。雖然未必準確，但低於此值之量測仍可指示患者需要醫療關注。 R represents the ratio of Hb to HbO2, which equates the actual SpO2 value (which is in the range of 0% O2 to 100% O2) to an empirical relationship similar to the nonlinear equation. In the case of above about 70% O2, this equation typically yields a value that is a few percent accurate. Although not necessarily accurate, measurements below this value may still indicate that the patient needs medical attention.
藉由發射光束通過樣本溶液，並利用折射計用預設比例觀察折射角度。樣本溶液中之溶解物質的量在折射率方面改變溶液的光學性質。當光自空氣傳遞至樣本溶液時，光的速度變得較慢且其方向受到折射。隨著溶解於溶液中的物質之量增加，光的速度變得更慢，使得折射角度改變更多。具體而言，在折射計中，來自光源之光線以小於稜鏡掠入射(grazing incidence)的所有角度入射於樣本上。詳言之，掠入射之光線以臨界角折射至稜鏡中，且在稜鏡之光出射面處具有所有其他光線中的最小折射角度。當經由望遠鏡觀看離開稜鏡之光時，此入射的結果為處於臨界角之光線界定陰影邊界。藉由量測陰影邊界與稜鏡之光出射面的法線之間的角度，可計算樣本的折射率。 The angle of refraction is observed by emitting a light beam through the sample solution and using a refractometer with a preset ratio. The amount of dissolved material in the sample solution changes the optical properties of the solution in terms of refractive index. When light is transferred from the air to the sample solution, the speed of the light becomes slower and its direction is refracted. As the amount of material dissolved in the solution increases, the speed of the light becomes slower, causing the angle of refraction to change more. Specifically, in a refractometer, light from a source is incident on the sample at all angles less than grazing incidence. In particular, the grazing incident light is refracted into the crucible at a critical angle and has the smallest angle of refraction in all other rays at the exit face of the pupil. When the light exiting the pupil is viewed through the telescope, the result of this incidence is the boundary of the shadow at the critical angle. The refractive index of the sample can be calculated by measuring the angle between the shadow boundary and the normal to the exit surface of the pupil.
血氧定量計以及折射計儀器兩者皆需要具有至少一波長的多個光源、複雜的光學元件以及至少一偵測器。對於分析應用，亦需要安裝有至少一測試程式的計算裝置。為了執行量測程序， 其包含激發光束、判定信號位準、計算測試結果以及輸出測試結果等。因此，現存的儀器通常是大型、難以操作且昂貴的。大體而言，每一個這些儀器是經訂製以用於特定測試或用於單一目的之測試。 Both oximeters and refractometer instruments require a plurality of light sources having at least one wavelength, complex optical components, and at least one detector. For analytic applications, a computing device with at least one test program is also required. In order to perform the measurement procedure, It includes the excitation beam, the decision signal level, the calculation of the test results, and the output test results. Therefore, existing instruments are typically large, difficult to operate, and expensive. In general, each of these instruments is custom-made for a particular test or for a single purpose test.
本申請揭露一種相對簡單的攜帶型裝置，其包含可與外部手持式計算裝置(諸如，智慧型手機)組合使用以用於分析目的的光學單元。此裝置可用於以類似於獨立血氧定量計的方式量測人的組織毛細血管中的飽和血紅蛋白的量。在具有相同設置的情況下，其亦可用於以類似於獨立折射計的方式判定液體樣本中的溶解物質的濃度。此外，亦可用於量測人的心搏。 The present application discloses a relatively simple portable device that includes an optical unit that can be used in combination with an external handheld computing device, such as a smart phone, for analytical purposes. This device can be used to measure the amount of saturated hemoglobin in human tissue capillaries in a manner similar to an independent oximeter. Where the same settings are present, it can also be used to determine the concentration of dissolved material in a liquid sample in a manner similar to an independent refractometer. In addition, it can also be used to measure the heart beat of a person.
在一實施例中，光學單元包含第一光束接收區域、樣本固持器、第一光束出射區域，以及具有第一反射表面以及第二反射表面的透鏡組件。第一反射表面用以將第一光束的光路自光束接收區域改變至第二反射表面。第二反射表面用以將第一光束重新導向至第一光束出射區域。樣本固持器位於第一光束的光路上。 In an embodiment, the optical unit includes a first beam receiving region, a sample holder, a first beam exit region, and a lens assembly having a first reflective surface and a second reflective surface. The first reflective surface serves to change the optical path of the first beam from the beam receiving region to the second reflecting surface. The second reflective surface is for redirecting the first beam to the first beam exit region. The sample holder is located on the optical path of the first beam.
在一實施例中，攜帶型分析裝置可包含光學單元以及適配裝置。適配裝置為固持器，其具有用於固持外部手持式計算裝置(EHCD)的第一部位，以及用於將光學單元定位至外部手持式計算裝置使得光學單元與EHCD對準的第二部位。 In an embodiment, the portable analysis device can include an optical unit and an adaptation device. The adapter device is a holder having a first portion for holding an external handheld computing device (EHCD) and a second portion for positioning the optical unit to an external handheld computing device such that the optical unit is aligned with the EHCD.
在另一實施例中，一種用於量測生理參數的攜帶型分析系統包含用於接收資料的輸入裝置、第一發射器、第二發射器、儲存資訊的記憶體、用於顯示所計算生理參數的輸出裝置，以及 耦接至輸入裝置、輸出裝置以及記憶體以用於控制程式常式的執行的處理單元。儲存資訊的記憶體包含多個測試程式常式。測試程式常式包含：觸發第一發射模組，以控制第一發射器朝向樣本發射具有第一波長的第一光束，及，觸發第二發射模組，以控制第二發射器朝向樣本發射具有第二波長的第二光束；啟動記錄器，以用於在預定持續時間中記錄由自樣本接收的第一光束以及第二光束導致的多個信號；以及啟用計算器，以用於基於所記錄信號計算多個生理參數。 In another embodiment, a portable analysis system for measuring physiological parameters includes an input device for receiving data, a first transmitter, a second transmitter, a memory for storing information, and for displaying the calculated physiological Output device for the parameter, and A processing unit coupled to the input device, the output device, and the memory for controlling the execution of the program routine. The memory for storing information contains multiple test program routines. The test routine includes: triggering a first transmitting module to control the first transmitter to emit a first beam having a first wavelength toward the sample, and triggering the second transmitting module to control the second transmitter to emit toward the sample a second beam of a second wavelength; activating a recorder for recording a plurality of signals resulting from the first beam received from the sample and the second beam for a predetermined duration; and enabling a calculator for recording based The signal calculates a plurality of physiological parameters.
在另一實施例中，一種用於量測飽和血紅蛋白含量的方 法包含以下步驟：(a)自外部手持式計算裝置將第一波長的第一光束以及第二波長的第二光束照射至樣本；(b)建立獲取時間以收集來自樣本的信號；(c)由外部手持式計算裝置中的多個接收器接收來自穿透樣本或自樣本反射的第一光束以及第二光束的多個信號，其中在外部手持式計算裝置上執行量測；以及(d)將每一個所接收信號的強度與預定義信號進行比較。若所接收信號的強度大於預定義信號，則藉由使用公式(1)來計算飽和血紅蛋白含量。若所接收信號的強度小於預定義信號，則延長步驟(b)中的獲取時間並重複步驟(c)至(d)。最後，(e)將飽和血紅蛋白的含量輸出至外部手持式計算裝置的顯示器上。 In another embodiment, a method for measuring saturated hemoglobin content The method comprises the steps of: (a) illuminating a first beam of a first wavelength and a second beam of a second wavelength to a sample from an external handheld computing device; (b) establishing an acquisition time to collect a signal from the sample; (c) Receiving, by a plurality of receivers in the external handheld computing device, a plurality of signals from the first beam and the second beam reflected from or in the sample, wherein the measuring is performed on the external handheld computing device; and (d) The strength of each received signal is compared to a predefined signal. If the intensity of the received signal is greater than the predefined signal, the saturated hemoglobin content is calculated by using equation (1). If the strength of the received signal is less than the predefined signal, the acquisition time in step (b) is extended and steps (c) through (d) are repeated. Finally, (e) the saturated hemoglobin content is output to the display of an external handheld computing device.
下文詳細描述伴有圖式之若干例示性實施例以進一步詳 細地描述本申請。 Several illustrative embodiments accompanied by the drawings are described in detail below for further details. This application is described in detail.
100‧‧‧光學單元 100‧‧‧ optical unit
102‧‧‧第一光束接收區域 102‧‧‧First beam receiving area
104‧‧‧透鏡組件 104‧‧‧ lens assembly
104a‧‧‧第一反射表面 104a‧‧‧First reflective surface
104b‧‧‧第二反射表面 104b‧‧‧second reflective surface
106‧‧‧第一樣本固持器 106‧‧‧First sample holder
108‧‧‧第一光束出射區域 108‧‧‧First beam exit area
110‧‧‧外部手持式計算裝置(EHCD) 110‧‧‧External Handheld Computing Unit (EHCD)
300‧‧‧圓柱形形狀光學單元 300‧‧‧Cylindrical shape optical unit
302‧‧‧第一光束接收區域 302‧‧‧First beam receiving area
303‧‧‧第二光束接收區域 303‧‧‧second beam receiving area
304‧‧‧圓錐形形狀透鏡組件 304‧‧‧Conical shape lens assembly
304a‧‧‧第一反射表面/第一反射點 304a‧‧‧First reflective surface/first reflection point
304b‧‧‧第二反射表面/第二反射點 304b‧‧‧second reflective surface/second reflection point
306‧‧‧圓柱形形狀樣本固持器 306‧‧‧Cylindrical shape sample holder
308‧‧‧第一光束出射區域 308‧‧‧First beam exit area
309‧‧‧第二光束出射區域 309‧‧‧second beam exit area
400‧‧‧攜帶型分析裝置 400‧‧‧ portable analyzer
410‧‧‧外部手持式計算裝置(EHCD) 410‧‧‧External Handheld Computing Unit (EHCD)
412‧‧‧第一光束發射器 412‧‧‧First beam emitter
414‧‧‧第一光束接收器 414‧‧‧First beam receiver
416‧‧‧第二光束發射器 416‧‧‧Second beam emitter
418‧‧‧適配裝置 418‧‧‧ Adaptation device
420‧‧‧第二光束接收器 420‧‧‧second beam receiver
430‧‧‧第一部位 430‧‧‧ first part
432‧‧‧第二部位 432‧‧‧Second part
500‧‧‧攜帶型分析裝置 500‧‧‧ portable analyzer
503‧‧‧第二光束接收區域 503‧‧‧second beam receiving area
507‧‧‧第二樣本固持器 507‧‧‧Second sample holder
509‧‧‧第二光束出射區域 509‧‧‧second beam exit area
510‧‧‧外部手持式計算裝置(EHCD) 510‧‧‧External Handheld Computing Unit (EHCD)
512‧‧‧第一光束發射器 512‧‧‧First beam emitter
514‧‧‧第一光束接收器 514‧‧‧First beam receiver
516‧‧‧第二光束發射器 516‧‧‧second beam emitter
520‧‧‧第二光束接收器 520‧‧‧second beam receiver
522‧‧‧第二樣本 522‧‧‧ second sample
524‧‧‧第一樣本 524‧‧‧ first sample
610‧‧‧外部手持式計算裝置(EHCD) 610‧‧‧External Handheld Computing Unit (EHCD)
612‧‧‧第一光束發射器 612‧‧‧First beam emitter
614‧‧‧第一光束接收器 614‧‧‧First beam receiver
615‧‧‧第二光束發射器 615‧‧‧Second beam emitter
616‧‧‧第二光束接收器 616‧‧‧second beam receiver
620‧‧‧光學單元 620‧‧‧ optical unit
620a‧‧‧第一反射表面 620a‧‧‧First reflective surface
620b‧‧‧第二反射表面 620b‧‧‧second reflective surface
622‧‧‧樣本 622‧‧‧ sample
626‧‧‧第一光束接收區域 626‧‧‧First beam receiving area
628‧‧‧第二光束離開表面 628‧‧‧The second beam leaves the surface
650‧‧‧樣本固持器 650‧‧‧sample holder
800‧‧‧攜帶型分析系統 800‧‧‧Portable Analysis System
810‧‧‧處理單元 810‧‧‧Processing unit
820‧‧‧輸入裝置 820‧‧‧ input device
830‧‧‧輸出裝置 830‧‧‧output device
840‧‧‧第一發射器 840‧‧‧First launcher
850‧‧‧第二發射器 850‧‧‧second transmitter
860‧‧‧儲存資訊的記憶體/記憶體單元 860‧‧‧Memory/memory unit for storing information
862‧‧‧第一發射模組 862‧‧‧First launch module
864‧‧‧第二發射模組 864‧‧‧Second launch module
866‧‧‧記錄器 866‧‧‧ Recorder
868‧‧‧計算器 868‧‧‧Calculator
870‧‧‧校準器 870‧‧‧ Calibrator
L‧‧‧光束 L‧‧‧beam
L1‧‧‧光束 L1‧‧‧ Beam
L2‧‧‧另一光束 L2‧‧‧Other beams
L3‧‧‧第一光束 L3‧‧‧First beam
L4‧‧‧第二光束 L4‧‧‧second beam
下文結合附圖以提供進一步的理解，且其併入本說明書 中並構成本說明書之部分。圖式用以說明實施例，並結合文字描述用以解釋本申請之原理。 Further understanding is provided below in conjunction with the drawings and incorporated in the specification It also forms part of this specification. The drawings are intended to be illustrative of the embodiments of the invention
圖1A為根據本申請之第一實施例的光學單元的橫截面圖。 1A is a cross-sectional view of an optical unit in accordance with a first embodiment of the present application.
圖1B為安置於外部手持式計算裝置上的本申請之第一實施例的光學單元的橫截面圖。 1B is a cross-sectional view of an optical unit of a first embodiment of the present application disposed on an external handheld computing device.
圖2為根據本申請之第一實施例的光學單元的立體圖。 2 is a perspective view of an optical unit in accordance with a first embodiment of the present application.
圖3A為用於接收具有第一波長之光束的根據本申請之第二實施例的光學單元的立體圖。 3A is a perspective view of an optical unit according to a second embodiment of the present application for receiving a light beam having a first wavelength.
圖3B為用於接收具有第二波長之另一光束的根據本申請之第二實施例的光學單元的立體圖。 3B is a perspective view of an optical unit according to a second embodiment of the present application for receiving another light beam having a second wavelength.
圖4為根據本申請之第二實施例的攜帶型分析裝置的立體圖，此攜帶型分析裝置具有適配裝置、圖3A以及圖3B之光學單元，以及外部手持式計算裝置。 4 is a perspective view of a portable analysis device having an adaptation device, the optical unit of FIGS. 3A and 3B, and an external handheld computing device in accordance with a second embodiment of the present application.
圖5為根據本申請之第三實施例的攜帶型分析裝置的立體圖，此攜帶型分析裝置藉由使用圖1A之光學單元、額外的樣本固持器以及外部手持式計算裝置，以用於雙指分析(dual-finger analysis)。 5 is a perspective view of a portable analysis device according to a third embodiment of the present application, which is used for two fingers by using the optical unit of FIG. 1A, an additional sample holder, and an external handheld computing device. Dual-finger analysis.
圖6為具有根據本申請之第四實施例的光學單元以及外部手持式計算裝置的攜帶型分析裝置的立體圖。 6 is a perspective view of a portable analysis device having an optical unit and an external handheld computing device in accordance with a fourth embodiment of the present application.
圖7為量測飽和血紅蛋白之含量的流程圖。 Figure 7 is a flow chart for measuring the content of saturated hemoglobin.
圖8為用於量測生理參數的攜帶型分析系統的方塊圖。 Figure 8 is a block diagram of a portable analysis system for measuring physiological parameters.
以下參照圖式來說明本申請之眾多實施例。在圖式中藉 由相同的元件符號表示相同或對應部分。一或多個所述實施例的不同部件及組件與另一部件及組件之互換屬於本申請之技術領域中具有通常知識者可預見之變化。 Numerous embodiments of the present application are described below with reference to the drawings. Borrowed in the schema The same or corresponding parts are denoted by the same element symbols. The interchange of various components and components of one or more of the described embodiments with another component and component is within the skill of the art in the present application.
圖1A為根據本申請之第一實施例的光學單元的橫截面 圖。圖1B為安裝於外部手持式計算裝置(諸如智慧型手機)上的經安置的本申請之第一實施例的光學單元的橫截面圖。圖2為如圖1A中所展示的根據本申請之第一實施例的光學單元的立體圖。光學單元100可包含光束接收區域102、透鏡組件104、樣本固持器106以及光束出射區域108。圖1A中展示光路的實例。光學單元100的材料可包括鏡面狀塗層、玻璃、塑膠、石英以及液體。舉例而言，光學單元100亦可為使用電潤濕之概念的液體透鏡，其中透鏡含有不可混溶的兩種液體：油及水。藉由電潤濕改變油滴之形狀。兩種液體皆是透明的，其具有不同的折射率但恰好相同的密度。 1A is a cross section of an optical unit according to a first embodiment of the present application Figure. 1B is a cross-sectional view of an optical unit of a first embodiment of the present application mounted on an external handheld computing device, such as a smart phone. 2 is a perspective view of the optical unit according to the first embodiment of the present application as shown in FIG. 1A. The optical unit 100 can include a beam receiving region 102, a lens assembly 104, a sample holder 106, and a beam exit region 108. An example of an optical path is shown in Figure 1A. The material of the optical unit 100 may include a mirror-like coating, glass, plastic, quartz, and liquid. For example, optical unit 100 can also be a liquid lens that uses the concept of electrowetting, where the lens contains two liquids that are immiscible: oil and water. The shape of the oil droplets is changed by electrowetting. Both liquids are transparent, having different refractive indices but exactly the same density.
光束接收區域102可用於接收自外部手持式計算裝置110 (圖1B)筆記型電腦之光束發射器(未展示)發射的光束L(圖1A)。外部手持式計算裝置110例如是智慧型手機、筆記型電腦、智慧型手錶以及平板電腦。自外部手持式計算裝置110之光束發射器接收的光束L，在用於血氧定量計以及折射計應用(例如，計算樣本的甜度或鹹度)時，其波長範圍介於約550nm至約700nm之間或介於約800nm至約1000nm之間。此外，光束接收區域102可耦接至外部手持式計算裝置110之光束發射器(未展示)，或與之對準。樣本固持器106用於固持諸如液體、手指的樣本或含有用於測試之樣本的試管。儘管存在許多不同種類之外部 手持式計算裝置，此處之外部手持式計算裝置110可為智慧型手機、筆記型電腦、攝影機、CD播放器、PDA、智慧型手錶或任何其他攜帶型數位設備。為簡單起見，下文將外部手持式計算裝置稱為EHCD。 The beam receiving area 102 can be used to receive from an external handheld computing device 110 (Fig. 1B) A light beam L emitted by a beam transmitter (not shown) of a notebook computer (Fig. 1A). The external handheld computing device 110 is, for example, a smart phone, a notebook computer, a smart watch, and a tablet computer. The light beam L received from the beam emitter of the external handheld computing device 110, when used in an oximeter and refractometer application (eg, calculating the sweetness or salinity of a sample), has a wavelength in the range of from about 550 nm to about Between 700 nm or between about 800 nm to about 1000 nm. Additionally, the beam receiving region 102 can be coupled to or aligned with a beam emitter (not shown) of the external handheld computing device 110. The sample holder 106 is used to hold a sample such as a liquid, a finger, or a test tube containing a sample for testing. Although there are many different kinds of external Handheld computing device, where the external handheld computing device 110 can be a smart phone, a notebook, a video camera, a CD player, a PDA, a smart watch, or any other portable digital device. For simplicity, the external handheld computing device is referred to below as an EHCD.
EHCD 110可包括充當光束發射器的攝影機、顯示器或其 他發光裝置。光束出射區域108為光束L離開光學單元100的地方。此外，光束出射區域108可耦接至EHCD 110之光束接收器，或與之對準。EHCD 110可進一步包括光學感測器(例如，近接感測器，用於偵測附近物件的影像感測器)以充當光束接收器。 EHCD 110 may include a camera, display or the like that acts as a beam emitter He illuminates the device. The beam exit region 108 is where the beam L exits the optical unit 100. Additionally, the beam exit region 108 can be coupled to or aligned with the beam receiver of the EHCD 110. The EHCD 110 may further include an optical sensor (eg, a proximity sensor for detecting an image sensor of nearby objects) to act as a beam receiver.
如圖1A所示，光學單元100經設計，使得將光束L自光 束接收區域102導引至光束出射區域108。光束之光路包括以下階段：(1)於光束接收區域102中被接收，(2)照射於第一反射表面104a並自第一反射表面104a反射，(3)穿過樣本固持器106，(4)照射於第二反射表面104b並自第二反射表面104b反射，以及(5)傳送至光束出射區域108。在此實例中，透鏡組件104具有第一反射表面104a以及第二反射表面104b。所述兩表面可為穿透反射性表面、反射性表面或其組合。穿透反射性表面允許光部分透射並部分反射。藉由光學單元100之第一反射表面104a以及第二反射表面104b，自EHCD 110之發射器發射的光束L之光路至光學單元100並返回至EHCD 110之接收器。當光束L返回至EHCD 110時，EHCD 110可記錄來自光束L的信號，並根據信號計算樣本的參數。接著，EHCD 110可顯示計算結果。另外，光束接收區域102以及出射區域108中的至少一者可為光束提供濾波及/或偏振功能。 As shown in FIG. 1A, the optical unit 100 is designed such that the light beam L is self-lighted. The beam receiving area 102 is directed to the beam exit area 108. The beam path of the beam includes the following stages: (1) being received in the beam receiving region 102, (2) illuminating the first reflecting surface 104a and reflecting from the first reflecting surface 104a, and (3) passing through the sample holder 106, (4) Illuminating the second reflective surface 104b and reflecting from the second reflective surface 104b, and (5) transmitting to the beam exit region 108. In this example, lens assembly 104 has a first reflective surface 104a and a second reflective surface 104b. The two surfaces can be transflective surfaces, reflective surfaces, or a combination thereof. Penetrating the reflective surface allows the light to be partially transmitted and partially reflected. The optical path of the light beam L emitted from the emitter of the EHCD 110 to the optical unit 100 and returned to the receiver of the EHCD 110 by the first reflective surface 104a and the second reflective surface 104b of the optical unit 100. When the light beam L is returned to the EHCD 110, the EHCD 110 can record the signal from the light beam L and calculate the parameters of the sample based on the signal. Next, the EHCD 110 can display the calculation result. Additionally, at least one of the beam receiving region 102 and the exit region 108 can provide filtering and/or polarization functions for the beam.
圖1中所展示之樣本固持器106位於光束L的光路上。 然而，在其他配置中，樣本固持器可能不必位於第一反射表面104a以及第二反射表面104b之間。舉例而言，用於固持樣本(例如，手指)的樣本固持器106可恰好位於第一反射表面104a抑或第二反射表面104b上。樣本固持器106的形狀可為(但不限於)圓柱形、矩形、鐘形、圓錐形、立方形、角錐形或多邊形形狀。對於折射計應用，光束L的光路的方向並不垂直於樣本固持器106的表面。 The sample holder 106 shown in Figure 1 is located on the optical path of the beam L. However, in other configurations, the sample holder may not necessarily be located between the first reflective surface 104a and the second reflective surface 104b. For example, the sample holder 106 for holding a sample (eg, a finger) can be located just on the first reflective surface 104a or the second reflective surface 104b. The shape of the sample holder 106 can be, but is not limited to, a cylindrical shape, a rectangular shape, a bell shape, a conical shape, a cubic shape, a pyramid shape, or a polygonal shape. For refractometer applications, the direction of the optical path of beam L is not perpendicular to the surface of sample holder 106.
另外，光學單元100可進一步包含第一準直儀(未展示)， 其設在光束接收區域102中，用於準直來自光束接收區域102的傳入光束L。光學單元100亦可包含第二準直儀(未展示)，其設在光束出射區域108中，用於準直自第二反射表面104b反射的傳出光束L。 Additionally, the optical unit 100 can further include a first collimator (not shown), It is disposed in the beam receiving region 102 for collimating the incoming beam L from the beam receiving region 102. The optical unit 100 can also include a second collimator (not shown) disposed in the beam exit region 108 for collimating the outgoing beam L reflected from the second reflective surface 104b.
此外，光學單元100可接收具有不同波長的額外光束(未 展示)。樣本固持器106亦位於額外光束的路徑中。因此，當樣本置放於樣本固持器106中時，EHCD藉由穿過樣本的具有不同波長的光束L以及額外光束來分析樣本的光學性質。以此方式，藉由自具有不同波長的兩個光束獲取資料而判定飽和血紅蛋白含量。 In addition, the optical unit 100 can receive additional light beams having different wavelengths (not Show). The sample holder 106 is also located in the path of the additional beam. Thus, when the sample is placed in the sample holder 106, the EHCD analyzes the optical properties of the sample by passing the beam L of different wavelengths and additional beams through the sample. In this way, the saturated hemoglobin content is determined by acquiring data from two beams having different wavelengths.
圖3A為用於接收具有第一波長之光束的根據本申請之 第二實施例的光學單元300的立體圖。在此實施例中，圓柱形形狀的光學單元300包含圓錐形形狀的透鏡組件304，且說明了圓柱形形狀的樣本固持器306。光學單元300經設計，使得將光束L1自光束接收區域302導引至光束出射區域308。光束L1之光路包 括以下階段：(1)於光束接收區域302中被接收，(2)照射於第一反射表面304a處並自所述表面反射，(3)穿過樣本固持器306，(4)照射於第二反射表面304b處並自所述表面反射，以及(5)傳送至光束出射區域308。 3A is a diagram for receiving a light beam having a first wavelength according to the present application A perspective view of the optical unit 300 of the second embodiment. In this embodiment, the cylindrically shaped optical unit 300 includes a conical shaped lens assembly 304 and illustrates a cylindrically shaped sample holder 306. The optical unit 300 is designed such that the light beam L1 is directed from the beam receiving region 302 to the beam exit region 308. Light beam package of light beam L1 The following stages are included: (1) being received in the beam receiving region 302, (2) being illuminated at the first reflecting surface 304a and reflected from the surface, (3) passing through the sample holder 306, and (4) being illuminated At and from the reflective surface 304b, and (5) are transmitted to the beam exit region 308.
在此實例中，透鏡組件304具有第一反射點304a以及第 二反射點304b。實際上此等兩點位於圓錐形形狀透鏡組件304的相同表面上。透鏡表面可為穿透反射性表面、反射性表面或其組合。穿透反射性表面允許光部分透射並部分反射。 In this example, lens assembly 304 has a first reflective point 304a and a Two reflection points 304b. These two points are actually located on the same surface of the conical shaped lens assembly 304. The lens surface can be a transflective surface, a reflective surface, or a combination thereof. Penetrating the reflective surface allows the light to be partially transmitted and partially reflected.
圖3B為用於接收具有第二波長之另一光束的根據本申 請之相同第二實施例的光學單元的立體圖。圖3B中展示光束接收區域303以及光束出射區域309。光學單元300之另一光束L2的光路包括以下階段：(1)於光束接收區域303被接收，(2)照射於樣本固持器306處並穿過樣本固持器306，以及(3)將反射光束傳送至光束出射區域309。 FIG. 3B is a diagram for receiving another light beam having a second wavelength according to the present application A perspective view of the optical unit of the second embodiment is similar. The beam receiving region 303 and the beam exit region 309 are shown in FIG. 3B. The optical path of the other beam L2 of the optical unit 300 includes the following stages: (1) being received at the beam receiving region 303, (2) illuminating the sample holder 306 and passing through the sample holder 306, and (3) reflecting the reflected beam It is transmitted to the beam exit area 309.
當樣本置放於樣本固持器306中時，EHCD經由自樣本 所反射的具有不同波長之光束L1以及L2來分析樣本的光學性質。在此實施例中，經由自光束L1以及光束L2獲取資料而判定飽和血紅蛋白含量。 When the sample is placed in the sample holder 306, the EHCD is passed through the self sample. The reflected light beams L1 and L2 having different wavelengths are used to analyze the optical properties of the sample. In this embodiment, the saturated hemoglobin content is determined by acquiring data from the light beam L1 and the light beam L2.
在其他實施例中，光學單元300可僅利用一組光束接收 區域302與光束出射區域308，或一組光束接收區域303與光束出射區域309。藉由僅具有一組光束接收區域與光束出射區域，僅量測一光束，所述光束可用於量測(例如)樣本的鹹度或甜度。在此狀況下，對於折射計應用，光束L1以及L2之光路的方向不垂直於樣本固持器306的表面。 In other embodiments, optical unit 300 can receive using only one set of beams Region 302 and beam exit region 308, or a set of beam receiving regions 303 and beam exit regions 309. By having only one set of beam receiving regions and beam exit regions, only one beam is measured, which beam can be used to measure, for example, the salinity or sweetness of the sample. In this case, for refractometer applications, the directions of the optical paths of beams L1 and L2 are not perpendicular to the surface of sample holder 306.
圖4為與適配裝置418組合使用的攜帶型分析裝置400 的立體圖。在此實施例中，光學單元300(來自圖3A抑或圖3B)以及EHCD 410彼此對準。此處，攜帶型分析裝置400包括光學單元300以及適配裝置418。適配裝置418具有用於固持EHCD 410的第一部位430，以及用於固持光學單元300的第二部位432，使得光學單元300對準EHCD 410。如圖4所示，第一部位430為用於固持EHCD 410的適配裝置418中之空間，且第二部位432為用於固持光學單元300的適配裝置418上之區域。EHCD 410的第一光束發射器412(例如，顯示器單元)與光學單元300的第一光束接收區域302對準。EHCD 410的第一光束接收器414(例如，攝影機)與光學單元300的第一光束出射區域308對準。EHCD 410的第二光束發射器416(例如，近接感測器)與光學單元300的第二光束接收區域303對準。EHCD 410的第二光束接收器420(例如，近接感測器)與光學單元300的第二光束出射區域309對準。 4 is a portable analysis device 400 for use in combination with an adaptation device 418. Stereogram. In this embodiment, optical unit 300 (from Figure 3A or Figure 3B) and EHCD 410 are aligned with one another. Here, the portable analysis device 400 includes an optical unit 300 and an adaptation device 418. The adapter device 418 has a first portion 430 for holding the EHCD 410 and a second portion 432 for holding the optical unit 300 such that the optical unit 300 is aligned with the EHCD 410. As shown in FIG. 4, the first portion 430 is the space in the adapter device 418 for holding the EHCD 410, and the second portion 432 is the region on the adapter device 418 for holding the optical unit 300. The first beam emitter 412 (e.g., display unit) of the EHCD 410 is aligned with the first beam receiving region 302 of the optical unit 300. The first beam receiver 414 (e.g., camera) of the EHCD 410 is aligned with the first beam exit region 308 of the optical unit 300. A second beam emitter 416 (eg, a proximity sensor) of the EHCD 410 is aligned with the second beam receiving region 303 of the optical unit 300. A second beam receiver 420 (eg, a proximity sensor) of the EHCD 410 is aligned with the second beam exit region 309 of the optical unit 300.
在一實施例中，第一準直儀(未展示)可耦接至EHCD 410 之至少一對應光束發射器，且第二準直儀(未展示)可耦接至EHCD 410之至少一對應光束接收器。EHCD 410可記錄來自光束的信號、基於信號計算資料，並顯示結果。攜帶型分析裝置400亦可用作用於分析諸如樣本之甜度、鹹度的光學性質的折射計。可替代地，攜帶型分析裝置400可為用於分析患者之飽和血紅蛋白或心搏率的血氧定量計。 In an embodiment, a first collimator (not shown) can be coupled to the EHCD 410 At least one corresponding beam emitter, and a second collimator (not shown) can be coupled to at least one corresponding beam receiver of the EHCD 410. The EHCD 410 records the signal from the beam, calculates the data based on the signal, and displays the result. The portable analyzer 400 can also be used as a refractometer for analyzing optical properties such as sweetness and saltiness of a sample. Alternatively, the portable analysis device 400 can be an oximeter for analyzing a patient's saturated hemoglobin or heart rate.
圖5為根據本申請之第三實施例的攜帶型分析裝置的立 體圖。此攜帶型分析裝置藉由使用光學單元100(如圖1以及圖2中所展示)、額外的樣本固持器507以及EHCD 510，以用於雙指 分析。在攜帶型分析裝置500中，光學單元100的第一光束接收區域102經對準，以自EHCD 510之第一光束發射器512(顯示器)接收光束。光學單元100的第一光束出射區域108對準至EHCD 510之第一光束接收器514(攝影機)。第一樣本(或手指)524置放於第一樣本固持器106上，所述樣本固持器形成於光學單元100之第二反射表面104b上。第二樣本(或手指)522置放於第二樣本固持器507上。第二樣本固持器507安置於EHCD 510之第二光束發射器516以及第二光束接收器520(近接感測器)上方。第二樣本522置放於第二樣本固持器507上，而光束自第二光束接收區域503穿過第二樣本522或自第二樣本522反射。由EHCD 510接收穿過第二樣本固持器507之第二光束出射區域509的光束。在此實施例中，第二光束接收區域503以及第二光束出射區域509位於大約相同之區域。在其他實施例中，第二光束接收區域503以及第二光束出射區域509亦可位於不同區域處。視情況，可省略第二樣本固持器507，使得第二樣本522可直接安置於第二光束發射器516以及第二光束接收器520區域上。實施例的第一樣本524以及第二樣本522可為(例如)使用者之兩個不同手指。 FIG. 5 is a diagram of a portable analysis device according to a third embodiment of the present application. Body map. This portable analysis device is used for two fingers by using optical unit 100 (as shown in Figures 1 and 2), additional sample holder 507, and EHCD 510. analysis. In portable analysis device 500, first beam receiving region 102 of optical unit 100 is aligned to receive a beam from first beam emitter 512 (display) of EHCD 510. The first beam exit region 108 of the optical unit 100 is aligned to the first beam receiver 514 (camera) of the EHCD 510. A first sample (or finger) 524 is placed on the first sample holder 106, which is formed on the second reflective surface 104b of the optical unit 100. A second sample (or finger) 522 is placed on the second sample holder 507. The second sample holder 507 is disposed above the second beam emitter 516 of the EHCD 510 and the second beam receiver 520 (proximity sensor). The second sample 522 is placed on the second sample holder 507, and the light beam is reflected from or reflected from the second sample 522 from the second beam receiving region 503. The light beam passing through the second beam exit region 509 of the second sample holder 507 is received by the EHCD 510. In this embodiment, the second beam receiving area 503 and the second beam exit area 509 are located in approximately the same area. In other embodiments, the second beam receiving region 503 and the second beam exit region 509 may also be located at different regions. Optionally, the second sample holder 507 can be omitted such that the second sample 522 can be disposed directly on the second beam emitter 516 and the second beam receiver 520 region. The first sample 524 and the second sample 522 of an embodiment can be, for example, two different fingers of a user.
在實施例中，第一光束發射器512以及第二光束發射器 516發射具有兩個不同波長之光束，以用於量測諸如飽和血紅蛋白含量的生理資料。可替代地，僅一光束發射器可用於發射僅一波長，以偵測僅要求一波長的生理資料，或量測樣本的甜度及鹹度。 In an embodiment, the first beam emitter 512 and the second beam emitter 516 emits a beam of light having two different wavelengths for measuring physiological data such as saturated hemoglobin content. Alternatively, only one beam emitter can be used to emit only one wavelength to detect physiological data requiring only one wavelength, or to measure the sweetness and salinity of the sample.
圖6為具有根據本申請之第四實施例的光學單元的攜帶型分析裝置的立體圖。光學單元620包含樣本固持器650、第一反 射表面620a、第二反射表面620b、第一光束接收區域626以及第一光束出射區域628。光學單元620對準至EHCD 610。所述EHCD 610包含第一光束發射器612(例如，顯示器)、第一光束接收器614(例如，攝影機)、第二光束發射器615以及第二光束接收器616。在本實施例中，第二光束發射器615以及第二光束接收器616可為智慧型手機之近接感測器。光學單元620中自第一光束發射器612所發射的第一光束L3之光路包括以下階段：(1)於光束接收區域626中被接收，(2)照射於第一反射表面620a處並自第一反射表面620a反射，(3)部分的第一光束L3穿過樣本622或自所述樣本622反射，(4)部分的第一光束L3自第二反射表面620b反射，以及(5)傳送至光束出射區域628。第一光束接收區域626以及第一光束出射區域628各自可進一步裝設有用於準直此等光束的準直儀。光學單元620經設計，使得第一光束接收區域626對準第一光束發射器612。第一光束L3自第一光束發射器612發射，並接收於第一光束接收區域626中。第一光束出射區域628對準至第一光束接收器614，使得在第一光束L3離開光束出射區域628之後，第一光束接收器614接收第一光束L3。另外，第一光束發射器612發射波長範圍介於550nm至700nm之間(或為白色光)的第一光束L3。第一光束接收區域626或第一光束出射區域628可裝設有用以選擇光束L3的特定波長的濾波裝置。 Fig. 6 is a perspective view of a portable type analyzing device having an optical unit according to a fourth embodiment of the present application. The optical unit 620 includes a sample holder 650, a first counter The surface 620a, the second reflective surface 620b, the first beam receiving region 626, and the first beam exit region 628. Optical unit 620 is aligned to EHCD 610. The EHCD 610 includes a first beam emitter 612 (eg, a display), a first beam receiver 614 (eg, a camera), a second beam emitter 615, and a second beam receiver 616. In this embodiment, the second beam emitter 615 and the second beam receiver 616 can be proximity sensors of a smart phone. The optical path of the first light beam L3 emitted from the first beam emitter 612 in the optical unit 620 includes the following stages: (1) being received in the beam receiving region 626, and (2) illuminated at the first reflecting surface 620a and from the first Reflected by a reflective surface 620a, the first beam L3 of the portion (3) passes through or is reflected from the sample 622, the first beam L3 of the portion (4) is reflected from the second reflective surface 620b, and (5) is transmitted to The beam exit region 628. The first beam receiving region 626 and the first beam exit region 628 can each be further provided with a collimator for collimating such beams. The optical unit 620 is designed such that the first beam receiving region 626 is aligned with the first beam emitter 612. The first light beam L3 is emitted from the first beam emitter 612 and received in the first beam receiving region 626. The first beam exit region 628 is aligned to the first beam receiver 614 such that after the first beam L3 exits the beam exit region 628, the first beam receiver 614 receives the first beam L3. Additionally, the first beam emitter 612 emits a first beam L3 having a wavelength ranging from 550 nm to 700 nm (or white light). The first beam receiving region 626 or the first beam exit region 628 can be provided with filtering means for selecting a particular wavelength of the beam L3.
光學單元620亦提供自第二光束發射器615所發射的第二光束L4之另一光路。第二光束L4之光路包括以下階段：(1)自第二光束發射器615進行接收，(2)照射於樣本622處並由所述樣本622接收，以及(3)將第二光束L4自樣本622反射以接 收於第二光束接收器616中。在實施例中，將光束L4直接自EHCD 610之第二光束發射器615發射至樣本622。在實施例中，發射兩個不同波長之光束，以便由兩波長來偵測信號。因此，可判定諸如飽和血紅蛋白含量的生理資料。可替代地，僅一光束發射器可用於發射僅一波長之光束，以偵測僅要求一波長的生理資料，或用於量測樣本之甜度及鹹度。此外，對於折射計應用，光束L3以及L4之光路的方向並不垂直於樣本固持器650的表面。 Optical unit 620 also provides another optical path from second beam L4 emitted by second beam emitter 615. The optical path of the second beam L4 includes the following stages: (1) receiving from the second beam emitter 615, (2) illuminating at the sample 622 and receiving by the sample 622, and (3) taking the second beam L4 from the sample. 622 reflection to pick up It is received in the second beam receiver 616. In an embodiment, beam L4 is emitted directly from second beam emitter 615 of EHCD 610 to sample 622. In an embodiment, two different wavelengths of light are emitted to detect signals from both wavelengths. Therefore, physiological data such as saturated hemoglobin content can be determined. Alternatively, only one beam emitter can be used to emit a beam of only one wavelength to detect physiological data requiring only one wavelength, or to measure the sweetness and salinity of the sample. Moreover, for refractometer applications, the directions of the optical paths of beams L3 and L4 are not perpendicular to the surface of sample holder 650.
圖7為根據本申請之實施例的量測飽和血紅蛋白含量的 流程圖。用於量測的方法包含以下步驟：(1)將兩個光束(具有第一波長的第一光束及具有第二波長的第二光束)自EHCD發射至至少一樣本(諸如，至少一手指)(S720)。(2)等待預定獲取時間以收集來自樣本的信號(S730)。(3)在第一光束以及第二光束穿透樣本或自樣本反射之後，由EHCD中之多個接收器自第一光束以及第二光束接收多個信號，其中在EHCD上執行量測(S740)。(4)將所接收信號的光強度與預定義信號比較(S750)。 若所量測信號的強度大於預定義信號(Smeasured>Spredefined)，則藉由使用公式SpO2=HbO2/(HbO2+Hb)計算飽和血紅蛋白含量(S760)。若強度小於預定義信號，則延長S730中的獲取時間並重複自S740至S750的步驟。詳言之，預定義信號Spredefined為閥值，用以確保所量測信號的強度Smeasured並非僅為雜訊信號，而是自光束接收的信號。若所量測信號的強度小於預定義信號，則延長獲取時間以便獲取較好品質的信號。最後，將自步驟S760計算的結果(亦即，飽和血紅蛋白含量)輸出至EHCD的顯示裝置上(S770)。亦可採用諸如藉由語音揚聲器的其他輸出裝置。可替代 地，可在步驟S720之前進行步驟S730。 7 is a flow chart for measuring saturated hemoglobin content in accordance with an embodiment of the present application. The method for metrology comprises the steps of: (1) transmitting two beams (a first beam having a first wavelength and a second beam having a second wavelength) from an EHCD to at least the same (eg, at least one finger) (S720). (2) Waiting for a predetermined acquisition time to collect a signal from the sample (S730). (3) After the first beam and the second beam penetrate the sample or are reflected from the sample, a plurality of signals are received from the first beam and the second beam by a plurality of receivers in the EHCD, wherein the measurement is performed on the EHCD (S740) ). (4) Comparing the light intensity of the received signal with a predefined signal (S750). If the intensity of the measured signal is greater than the predefined signal (S measured > S predefined ), the saturated hemoglobin content (S760) is calculated by using the formula SpO2 = HbO2 / (HbO2 + Hb). If the intensity is less than the predefined signal, the acquisition time in S730 is extended and the steps from S740 to S750 are repeated. In detail, the predefined signal S predefined is a threshold to ensure that the measured intensity S measured is not only a noise signal but a signal received from the beam. If the strength of the measured signal is less than the predefined signal, the acquisition time is extended to obtain a better quality signal. Finally, the result calculated from step S760 (i.e., the saturated hemoglobin content) is output to the display device of the EHCD (S770). Other output devices such as by voice speakers can also be employed. Alternatively, step S730 may be performed before step S720.
圖8為用於量測生理參數的攜帶型分析系統的方塊圖。 根據上文的實施例，提供用於量測生理參數或樣本參數的攜帶型分析系統800。攜帶型分析系統800包含：用於接收資料的輸入裝置820(諸如，觸控面板、小鍵盤、麥克風等)；用於儲存資訊的記憶體單元860；用於輸出所計算的參數的輸出裝置830(諸如，顯示器、揚聲器等)；用於發射不同波長之光束的第一發射器840、第二發射器850；以及耦接至輸入裝置820、輸出裝置830、第一發射器840、第二發射器850以及儲存資訊的記憶體860以用於控制程式常式之執行的處理單元810。第一發射器840可為先前實施例之EHCD的顯示器。第二發射器850可為先前實施例之EHCD的近接感測器。儲存資訊的記憶體860包含多個程式常式。程式常式包含：(1)用於控制第一發射器840發射具有第一波長之第一光束的第一發射模組862；(2)用於控制第二發射器850朝向樣本發射具有第二波長之第二光束的第二發射模組864，(3)用於在預定持續時間中記錄由自樣本接收的第一光束以及第二光束導致的多個信號的記錄器866，以及(4)用於基於所記錄信號計算多個參數的計算器868。儲存資訊的記憶體可進一步包含用於校準的校準器870，以確保信號強度到達預定義信號閥值。儲存資訊的記憶體可為EHCD內部的記憶體裝置。 Figure 8 is a block diagram of a portable analysis system for measuring physiological parameters. According to the above embodiments, a portable analysis system 800 for measuring physiological parameters or sample parameters is provided. The portable analysis system 800 includes: an input device 820 (such as a touch panel, a keypad, a microphone, etc.) for receiving data; a memory unit 860 for storing information; and an output device 830 for outputting the calculated parameters. (such as a display, a speaker, etc.); a first transmitter 840 for transmitting beams of different wavelengths, a second transmitter 850; and an input device 820, an output device 830, a first transmitter 840, a second emission The device 850 and the memory 860 storing the information are used by the processing unit 810 for controlling the execution of the program routine. The first transmitter 840 can be the display of the EHCD of the previous embodiment. The second transmitter 850 can be a proximity sensor of the EHCD of the previous embodiment. The memory 860 storing information contains a plurality of program routines. The program routine includes: (1) a first transmitting module 862 for controlling the first transmitter 840 to emit a first light beam having a first wavelength; (2) for controlling the second transmitter 850 to emit a second toward the sample. a second emission module 864 of a second beam of wavelengths, (3) a recorder 866 for recording a plurality of signals caused by the first beam and the second beam received from the sample for a predetermined duration, and (4) A calculator 868 for calculating a plurality of parameters based on the recorded signals. The memory storing the information may further include a calibrator 870 for calibration to ensure that the signal strength reaches a predefined signal threshold. The memory for storing information can be a memory device inside the EHCD.
在實施例中，輸入裝置820可為先前實施例之EHCD的觸控面板或鍵盤。輸出裝置830可為先前實施例之EHCD的顯示裝置、語音揚聲器、振動器、閃爍器、印表機、傳輸器或其組合。第一發射器840可為輸出裝置830的顯示器。然而，第一發射器 840以及輸出裝置830亦可以是分離的。 In an embodiment, the input device 820 can be the touch panel or keyboard of the EHCD of the previous embodiment. The output device 830 can be the display device of the EHCD of the previous embodiment, a voice speaker, a vibrator, a scintillator, a printer, a transmitter, or a combination thereof. The first transmitter 840 can be a display of the output device 830. However, the first transmitter 840 and output device 830 can also be separate.
在實施例中，攜帶型分析系統800量測飽和血紅蛋白含 量，其中自樣本所接收的信號中之至少一者為反射光束信號。可替代地，攜帶型分析系統800量測飽和血紅蛋白含量，其中自樣本所接收的信號中之一者為穿透光束信號。攜帶型分析系統800量測包含飽和血紅蛋白值以及心搏率值的生理參數。 In an embodiment, the portable analysis system 800 measures saturated hemoglobin A quantity, wherein at least one of the signals received from the sample is a reflected beam signal. Alternatively, the portable analysis system 800 measures the saturated hemoglobin content, wherein one of the signals received from the sample is a transmitted beam signal. The portable analysis system 800 measures physiological parameters including saturated hemoglobin values and heart rate values.
本申請進一步提供程式儲存媒體，其儲存用於執行量測 多個生理參數的各種步驟的程式。所述程式執行包含以下步驟：(1)朝向樣本發射具有第一波長的第一光束以及具有第二波長的第二光束；(2)在預定持續時間中記錄由自樣本反射的第一光束以及第二光束導致的多個信號；(3)基於所記錄信號計算生理參數，以及(4)將所計算生理參數報告至輸出裝置。程式儲存媒體可安裝於EHCD內的儲存裝置中。當安裝於EHCD中的程式儲存媒體經調適用於先前實施例的光學單元時，所述程式儲存媒體可用於獲得生理資料。此處所提及的EHCD包含(例如)平板電腦、攜帶型電腦、可穿戴式裝置、手錶或智慧型手機。然而，本申請並不限於此情況。程式儲存媒體可安裝於其他計算裝置中以用於獲得資料。 The application further provides a program storage medium, which is stored for performing measurement A program of various steps of multiple physiological parameters. The program execution comprises the steps of: (1) emitting a first beam having a first wavelength toward a sample and a second beam having a second wavelength; (2) recording a first beam reflected from the sample for a predetermined duration and a plurality of signals resulting from the second beam; (3) calculating physiological parameters based on the recorded signals, and (4) reporting the calculated physiological parameters to the output device. The program storage medium can be installed in a storage device in the EHCD. The program storage medium can be used to obtain physiological data when the program storage medium installed in the EHCD is adapted to the optical unit of the previous embodiment. The EHCD referred to herein includes, for example, a tablet, a portable computer, a wearable device, a watch, or a smart phone. However, the application is not limited to this case. The program storage medium can be installed in other computing devices for obtaining data.
熟習此項技術者將顯而易見，在不脫離本申請之範疇或精神的情況下，可對所揭露實施例的結構作出各種修改及變化。鑒於前述內容，本申請意在涵蓋本申請的修改及變化，只要所述修改及變化屬於以下申請專利範圍及其等效物的範疇內。 It will be apparent to those skilled in the art that various modifications and changes can be made in the structure of the disclosed embodiments without departing from the scope of the invention. In view of the foregoing, it is intended that the present invention covers the modifications and variations of the present invention as long as they are within the scope of the following claims and their equivalents.
300‧‧‧圓柱形形狀光學單元 300‧‧‧Cylindrical shape optical unit
302‧‧‧第一光束接收區域 302‧‧‧First beam receiving area
303‧‧‧第二光束接收區域 303‧‧‧second beam receiving area
304‧‧‧圓錐形形狀透鏡組件 304‧‧‧Conical shape lens assembly
304b‧‧‧第二反射表面/第二反射點 304b‧‧‧second reflective surface/second reflection point
306‧‧‧圓柱形形狀樣本固持器 306‧‧‧Cylindrical shape sample holder
308‧‧‧第一光束出射區域 308‧‧‧First beam exit area
309‧‧‧第二光束出射區域 309‧‧‧second beam exit area
400‧‧‧攜帶型分析裝置 400‧‧‧ portable analyzer
410‧‧‧外部手持式計算裝置(EHCD) 410‧‧‧External Handheld Computing Unit (EHCD)
412‧‧‧第一光束發射器 412‧‧‧First beam emitter
414‧‧‧第一光束接收器 414‧‧‧First beam receiver
416‧‧‧第二光束發射器 416‧‧‧Second beam emitter
418‧‧‧適配裝置 418‧‧‧ Adaptation device
420‧‧‧第二光束接收器 420‧‧‧second beam receiver
430‧‧‧第一部位 430‧‧‧ first part
432‧‧‧第二部位 432‧‧‧Second part
L1‧‧‧光束 L1‧‧‧ Beam
L2‧‧‧另一光束 L2‧‧‧Other beams
Claims (41)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| TW103110711A TWI551269B (en) | 2014-03-21 | 2014-03-21 | Portable analytical device and system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| TW103110711A TWI551269B (en) | 2014-03-21 | 2014-03-21 | Portable analytical device and system |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW201536255A true TW201536255A (en) | 2015-10-01 |
| TWI551269B TWI551269B (en) | 2016-10-01 |
Family
ID=54850653
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW103110711A TWI551269B (en) | 2014-03-21 | 2014-03-21 | Portable analytical device and system |
Country Status (1)
| Country | Link |
|---|---|
| TW (1) | TWI551269B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111465882A (en) * | 2017-02-08 | 2020-07-28 | Essenlix公司 | Optical device, apparatus and system for assays |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7375815B2 (en) * | 2004-10-12 | 2008-05-20 | Agilent Technologies, Inc. | Optical devices, systems and method for producing a collimated light path |
| TWI470299B (en) * | 2011-12-05 | 2015-01-21 | Ind Tech Res Inst | Method and apparatus for auto-focusing |
-
2014
- 2014-03-21 TW TW103110711A patent/TWI551269B/en active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111465882A (en) * | 2017-02-08 | 2020-07-28 | Essenlix公司 | Optical device, apparatus and system for assays |
| CN111465882B (en) * | 2017-02-08 | 2023-05-26 | Essenlix公司 | Optical device, apparatus and system for assay |
Also Published As
| Publication number | Publication date |
|---|---|
| TWI551269B (en) | 2016-10-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US6466807B1 (en) | Optical glucose detector | |
| US10799128B2 (en) | Optical vital signs sensor | |
| JP6108498B2 (en) | Method and apparatus for selecting a wavelength for optimal measurement of molecular analyte properties | |
| US9222832B2 (en) | Device and method for detecting and monitoring ingredients or properties of a measurement medium, in particular of physiological blood values | |
| CN101557752B (en) | Method for the glucose concentration in pulsational blood | |
| JP4701468B2 (en) | Biological information measuring device | |
| CN101346097B (en) | System for non-invasive measurement of blood glucose concentration | |
| JP2018519889A (en) | Photoelectric volume pulse wave recording device | |
| EP2360464A1 (en) | Biological information detector, biological information measuring device, and method for designing reflecting part in biological information detector | |
| US20100240973A1 (en) | Blood oximeter | |
| JPH07506987A (en) | Non-invasive blood chemistry measurement using infrared stimulated relaxed emission | |
| KR20160086710A (en) | Method and apparatus for simultaneously detecting body surface pressure and blood volume | |
| CN106061385A (en) | Measurement device and measurement method | |
| JP2004290544A (en) | Blood analyzer | |
| AU2020352919B2 (en) | Physiological monitoring system for measuring oxygen saturation | |
| JP2004248820A (en) | Blood analyzer | |
| US9357955B2 (en) | Portable analytical device and system | |
| US20140128695A1 (en) | Portable 2-dimension oximeter image device | |
| RU2730438C2 (en) | Whole blood so2 sensor | |
| KR20180106664A (en) | Apparatus and method for measuring a biometrics information | |
| KR101661287B1 (en) | Method For Non-Invasive Glucose Measurement And Non-Invasive Glucose Measuring Apparatus using the same Method | |
| TWI551269B (en) | Portable analytical device and system | |
| KR20150050523A (en) | Noninvasive measurement of analyte concentration using a fiberless transflectance probe | |
| Wu et al. | A compact calibratable pulse oximeter based on color filters: towards a quantitative analysis of measurement uncertainty | |
| EP3784115A1 (en) | A method of assessment of microcirculation oscillations and device therefor |