TW201534328A - 含有鑽石粒子之口腔用組成物(一) - Google Patents
含有鑽石粒子之口腔用組成物(一) Download PDFInfo
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- TW201534328A TW201534328A TW103119719A TW103119719A TW201534328A TW 201534328 A TW201534328 A TW 201534328A TW 103119719 A TW103119719 A TW 103119719A TW 103119719 A TW103119719 A TW 103119719A TW 201534328 A TW201534328 A TW 201534328A
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- Prior art keywords
- cerium oxide
- particles
- oral composition
- oxide particles
- average particle
- Prior art date
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- 239000000203 mixture Substances 0.000 title claims abstract description 53
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- 229910000420 cerium oxide Inorganic materials 0.000 claims description 73
- BMMGVYCKOGBVEV-UHFFFAOYSA-N oxo(oxoceriooxy)cerium Chemical compound [Ce]=O.O=[Ce]=O BMMGVYCKOGBVEV-UHFFFAOYSA-N 0.000 claims description 71
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Abstract
本發明以提供一種具備優異清掃性及平滑性之口腔用組成物為課題。藉由本發明,可提供一種含有鑽石粒子及二氧化矽粒子之口腔用組成物。
Description
本發明是關於含有鑽石粒子之口腔用組成物,更詳細的說,是關於含有鑽石粒子及二氧化矽粒子之口腔用組成物。本申請案是主張已於2013年6月7日提出申請之日本專利申請第2013-120778號優先權者,且該專利申請案之說明書及/或圖式所記載的內容可藉由參照而被納入本說明書中。
牙齒的著色是因為被稱作色斑(stain)的色素沉積物沉積到牙齒而產生。而這會成為諸如在審美上的大問題。就用以除去色斑的手段而言,藉由牙刷等用具將摻合有牙齒研磨劑之磨齒組成物等的口腔用組成物含在口中並刷掃牙齒的方法較為一般。又,對於口腔用組成物,不僅止於可有效率地除去色斑,亦期待其具有讓使用後的牙齒表面平滑(滑溜),使色斑等難以附著而保持牙齒美觀之效果。
一般來說,往往會認為含有研磨力越大之牙齒研磨劑的口腔用組成物其清掃性或平滑性越會提高。然而,
一但研磨力大,則會有使牙齒表面發生必要以上的磨耗之虞,此時,即便可除去色斑,牙齒本身也會逐漸磨耗。一但牙齒表面被摩耗,則會產生象牙質露出而引起知覺過敏之虞。又,因露出之象牙質耐酸性低,亦可能變得會助長齲齒。更進一步來說,即使研磨力大,也難以預測是否可使牙齒表面平滑,視情況而定,也可預想會有牙齒表面被研磨至必要程度以上而形成凹凸的情形。
如上述,乃期許口腔用組成物能具備色斑除去能力(以下亦稱「清掃性」)及使牙齒表面平滑之能力(以下亦稱「平滑性」)的雙方能力。
專利文獻1:國際公開第10/060653號說明書
本發明以提供一種具備優異清掃性及平滑性之口腔用組成物為課題。
本案發明人發現,含有鑽石粒子及二氧化矽粒子之口腔用組成物具有優異的清掃性及平滑性,更經反覆改良而終至完成本發明。
亦即,本發明包含,例如以下項次所記載之主題。
項1. 一種口腔用組成物,含有鑽石粒子及二氧化矽粒子。
項2. 如項1之口腔用組成物,其中前述鑽石粒子之平均粒徑(d50)為0.5~5μm。
項3. 如項1或2之口腔用組成物,其中前述二氧化矽粒子之平均粒徑(d50)為0.5~20μm。
項4. 如項1至3中任一項之口腔用組成物,其含有前述鑽石粒子0.01~0.5質量%。
項5. 如項1至4中任一項之口腔用組成物,其中前述二氧化矽粒子是由第1二氧化矽粒子與第2二氧化矽粒子之組合所構成,該第1二氧化矽粒子之平均粒徑(d50)為3~5.5μm且吸油量為20~80(mL/100g),第2二氧化矽粒子之平均粒徑(d50)為6~15μm且吸油量為90~150(mL/100g)。
項6. 如項1至5中任一項之口腔用組成物,其相對於前述鑽石粒子0.01~0.5質量份,含有前述二氧化矽粒子1~35質量份。
藉由使用本發明口腔用組成物來保養牙齒(例如,刷掃),不僅可有效率的除去色斑,亦可讓使用後的牙齒表面平滑(滑溜)而保持牙齒美觀。亦即,本發明口腔用組成物具有優異的清掃性及平滑性。
以下針對本發明做更詳細的說明。
本發明口腔用組成物含有鑽石粒子及二氧化矽
粒子。
該鑽石粒子之平均粒徑(50%累積徑:d50)宜為0.5~5μm,且以1~4μm為佳,2~3μm更佳。
又進一步,99%累積徑(d99)宜為7μm以下,且以5μm以下為佳,4.5μm以下更佳。
又進一步,10%累積徑(d10)宜為0.1μm以上,且以0.5μm以上為佳,1μm以上更佳,1.8μm以上尤佳。
針對上述d50、d99、d10之各條件(適宜範圍),宜為滿足d50條件之鑽石粒子,且以滿足d50及d99條件或者滿足d50及d10條件之鑽石粒子為佳,以滿足d50、d99及d10條件之鑽石粒子更佳。
此種鑽石粒子可使用天然物或者合成物,合成物可使用如高溫高壓合成法、化學氣象蒸著法、爆發合成法、超音波空化法等習知方法來合成。
此外,本說明書中鑽石粒子的累積徑是使用水作為分散液並以庫爾特原理(細孔電阻法)求得之值(亦即,利用庫爾特計數器(Coulter counter)求得之值)。該值可利用諸如庫爾特計數器Multisizer 3(Beckman Coulter股份有限公司製)來測定。
本發明口腔用組成物所含有之二氧化矽粒子舉例來說可使用:習知已知可用在口腔用組成物且以濕式法或乾式法合成出之二氧化矽。由於以濕式法合成之二氧化矽在清掃性與研磨性上的平衡度適合本案發明,因此以濕式法合成之二氧化矽為宜。濕式法包含沉澱法或凝膠法。
以濕式法獲得之二氧化矽可大致區分為:以沉澱法合成之沉澱法二氧化矽及以凝膠法合成之凝膠法二氧化矽。在本發明中,任一種二氧化矽皆可使用。沉澱法二氧化矽較凝膠法二氧化矽適宜的情況較多,然並無特別限制。此外,所謂適宜之情況較多,是指沉澱法二氧化矽在下述之平均粒徑、吸油量及BET比表面積上具有適宜數值的情況較多。
本發明使用之二氧化矽粒子可購買市售品來使用。沉澱二氧化矽粒子可舉例如Aerosil、Ultrasil、Carplex(以上,Evonik Degussa公司製)、Aerosil(日本Aerosil公司製)、Zeodent(Huber公司製)、EXCELICA、REOLOSIL(以上,Tokuyama公司製)、Syilsia(富士silysia化學公司製)、Sorbosil(INEOS製)、DENKA溶融二氧化矽(電氣化學工業公司製)、Nipsil、Nipgel(以上,Tosoh Silica公司製)及Zeosil、Tixosil(Solvay公司製)等。於此等之中,可舉Zeodent(Huber公司製)、Sorbosil AC(PQ Corporation公司製)、Tixosil(Rhodia公司製)為較佳例,其等為沉澱法二氧化矽。
該二氧化矽粒子之平均粒徑(d50)宜為0.5~20μm,且以1~15μm為佳,以2~13μm更佳,以3.5~13μm尤佳。又,吸油量(亞麻油吸油量JIS K5101)宜為10~200(mL/100g),且以20~150(mL/100g)為佳,以25~140(mL/100g)更佳,以30~135(mL/100g)尤佳。
又,本發明口腔用組成物所含有之二氧化矽粒子宜由不同性狀之二氧化矽粒子組合而成之二氧化矽粒子所
構成。雖可使用2種或其以上(例如3種、4種或5種)之二氧化矽粒子之組合,然最佳之情況為使用2種不同性狀之二氧化矽的組合。將使用2種不同性狀之二氧化矽組合之情況的例子顯示如下。若令所組合之2種二氧化矽粒子分別為第1二氧化矽粒子及第2二氧化矽粒子,則第1二氧化矽粒子之平均粒徑(d50)宜在3~5.5μm之範圍(3.5~5μm之範圍為佳),吸油量(亞麻油吸油量JISK5101)宜在20~80(mL/100g)之範圍(30~70(mL/100g)之範圍為佳)。又,第2二氧化矽粒子之平均粒徑(d50)宜在6~15μm之範圍(6~12μm之範圍為佳),吸油量(亞麻油吸油量JIS K5101)宜在90~150(mL/100g)之範圍(90~140(mL/100g)之範圍為佳)。
此外,本說明書中二氧化矽之平均粒徑(d50)是使用水作為分散液並藉由雷射繞射散射法來求得的值。舉例來說,可使用低功率He/Ne雷射並使用利用佛朗霍菲繞射(Fraunhofer diffraction)原理之Malvern Mastersizer來測定該值。
又,本發明之口腔用組成物中,前述鑽石粒子宜含有0.01~0.5質量%,且以含有0.05~0.2質量%為佳。又,前述二氧化矽粒子宜含有1~35質量%,且以2~30質量%為佳。
又,在本發明口腔用組成物中,相對於前述鑽石粒子0.01~0.5質量份(宜為0.05~0.2質量份),前述二氧化矽粒子宜含有1~35質量份,且以含有5~30質量份為佳。其中,相對於前述鑽石粒子0.01~0.5質量份,前述二氧化矽粒子以
含有15~30質量份為佳,且相對於前述鑽石粒子0.05~0.2質量份,前述二氧化矽粒子以含有20~30質量份尤佳。
前述二氧化矽粒子使用第1二氧化矽粒子與第2二氧化矽粒子之組合時,相對於第1二氧化矽粒子1質量份,第2二氧化矽粒子宜使用0.5~25質量份,且以使用1~20質量份為佳,使用1~10質量份甚佳,使用1~5質量份更佳,使用1.5~4.5質量份為優,使用2~4質量份更優,使用2.5~3.5質量份為最優。
又,在摻合量方面,第1二氧化矽粒子宜為2~8質量%且以3~7質量%為佳,又,第2二氧化矽粒子宜為2~25質量%且以5~22質量%為佳。
本發明之口腔用組成物可以習知的方法製造。又,本發明口腔用組成物可使用在牙齒用及義齒用中之任一者,且可依循常法而製成膏狀(paste)磨齒劑、粉狀磨齒劑、霜狀(cream)磨齒劑、凝膠狀磨齒劑、液狀磨齒劑及糊(pasta)劑等各劑型。特別適宜製成膏狀磨齒劑、粉狀磨齒劑、霜狀磨齒劑或凝膠狀磨齒劑。
舉例來說,可藉由混合藥學上或口腔衛生學上所許容的基材、鑽石粒子及二氧化矽粒子(以及因應需要之其他成分)來製造本發明之口腔用組成物。此種基材可例示如水、甘油、乙二醇、二乙二醇、聚乙二醇、丙二醇、聚丙二醇、山梨糖醇、木糖醇、乳糖醇、甘露醇及乙醇等。
本發明之口腔用組成物亦可摻合一般被添加在口腔用組成物之其他成分(任意成分)。
例如,在界面活性劑方面,可摻合非離子界面活性劑、陰離子界面活性劑或兩性界面活性劑。具體而言,非離子界面活性劑可舉例如脂肪酸酯、脂肪酸烷醇醯胺酯類、脂肪酸去水山梨糖醇酯、脂肪酸單甘油酯、脂肪酸聚甘油酯、聚氧乙烯烷基苯基醚、烷基醣苷、癸二酸二乙酯、聚氧乙烯氫化蓖麻油、脂肪酸聚氧乙烯去水山梨糖醇酯等。陰離子界面活性劑可舉例如烷基硫酸酯鹽(例如月桂基硫酸鈉)、聚氧乙烯烷基醚硫酸酯鹽、烷基磺基琥珀酸鹽、聚氧乙烯烷基醚磺基琥珀酸鹽、N-醯基胺基酸鹽、N-醯基牛磺酸鹽、烷基醚羧酸鹽、烷基磷酸鹽、聚氧乙烯烷基醚磷酸鹽、脂肪酸單甘油酯硫酸鹽、烷基磺酸基醋酸鹽等。兩性離子界面活性劑方面可舉例如烷基二甲基胺基醋酸甜菜鹼、烷基醯胺基丙基二甲基胺基醋酸甜菜鹼、N-醯基-N-羧基甲基-N-羥基乙基乙二胺、N-烷基胺基乙基甘胺酸等。該等界面活性劑可單獨摻合或組合2種以上來摻合。相對於組成物總量,其摻合量通常為0.1~10質量%。
作為增稠劑,可摻合諸如卡拉膠、羧甲基纖維素或其鹽、羥丙基纖維素、羥丙基甲基纖維素、羥乙基纖維素、結晶纖維素.羧甲基纖維素鈉等纖維素衍生物;黃原膠、黃蓍膠、刺梧桐膠、***膠、結冷膠等膠類;聚乙烯醇、聚丙烯酸鈉、羧基乙烯聚合物、聚乙烯基吡咯烷酮等合成黏合劑;增稠性二氧化矽、矽烷化處理二氧化矽、矽鋁膠、矽酸鎂鋁等無機黏合劑;海藻酸鈉、果膠、大豆多糖類、軟骨素硫酸鈉、玻尿酸鈉等。該等增稠劑可單獨摻合或組
合2種以上作摻合。增稠劑的通常摻合量為0.01~20質量%。
作為香味劑,舉例來說,可將薄荷腦、羧酸、茴香腦、丁香酚、水楊酸甲酯、檸檬烯、蘿勒萜、正癸醇、香茅醛(Citronelle)、α-萜品醇、乙酸甲酯、乙酸香茅酯、甲基丁香酚、桉樹腦、沉香醇、乙基沉香醇、百里香酚、綠薄荷油(spearmint)、西洋薄荷油(peppermint)、檸檬油、橙油、鼠尾草油、迷迭香油、桂皮油、紫蘇油、冬青油、丁香油、尤加利油、甜椒油、d-樟腦、d-龍腦、茴香油、肉桂油、肉桂醛、薄荷油(mint oil)、香草醛等香料單獨摻合或組合2種以上作摻合,且相對於組成物總量,通常可摻合0.01~1質量%。
又,舉例來說,可單獨摻合或以組合2種以上之方式來摻合諸如糖精鈉、乙醯磺胺酸鉀、甜菊糖、甜菊萃取物、新橙皮苷二氫查爾酮(neohesperidinyl dihydrochalcone)、甘草酸、紫蘇糖、索馬甜、天冬醯胺基***醯基甲酯及對甲氧基肉桂醛等之甜味劑,且相對於組成物總量,通常可摻合0.01~1質量%。
進一步來說,可單獨摻合或以組合2種以上之方式摻合諸如山梨糖醇、乙二醇、丙二醇、甘油、1,3-丁二醇、聚丙二醇、木糖醇、麥芽糖醇、乳糖醇、巴拉金糖(palatinit)及聚乙二醇等來作為濕潤劑。
又,作為防腐劑,可單獨摻合或以組合2種以上之方式來摻合:對羥苯甲酸甲酯、對羥基苯甲酸乙酯、對羥基苯甲酸丙酯、對羥基苯甲酸丁酯等之對羥基苯甲酸酯
類;安息香酸鈉、苯氧乙醇、鹽酸烷基二胺基乙基甘胺酸等。
又,亦可單獨摻合或以組合2種以上之方式來摻合藍色1號、黃色4號、紅色202號、綠3號等法定色素、群青、強化群青、鐵青等礦物系色素以及氧化鈦等來作為著色劑。
又,亦可摻合檸檬酸、磷酸、蘋果酸、焦磷酸、乳酸、酒石酸、甘油磷酸、酢酸、硝酸、其等在化學上可能的鹽或氫氧化鈉來作為pH調整劑。該等可單獨摻合或以組合2種以上之方式作摻合以使組成物之pH成為4~8(宜為5~7)之範圍。pH調整劑的摻合量可例示如0.01~2重量%。
此外,在本發明之口腔用組成物中,作為藥效成分,可以單獨摻合或以組合2種以上之方式摻合諸如:西吡氯銨、苯扎氯銨、芐索氯銨、鹽酸氯已定等陽離子性殺菌劑;醋酸dl-α-生育酚酯、琥珀酸生育酚酯、或菸鹼酸生育酚酯等維他命E類;甘胺酸十二基二胺基乙酯等兩性殺菌劑;二氯苯氧氯酚、異丙基甲苯酚等非離子性殺菌劑劑;聚葡萄糖酶、澱粉酶、蛋白酶、齒斑葡聚醣酶、溶菌酶、溶菌酵素(lytic enzyme)等酵素;單氟磷酸鈉、氟化鈉、氟化亞錫等氟化物;傳明酸或ε-胺己酸、鋁氯羥基尿囊素、二氫膽固醇、甘草酸、甘油磷酸鹽(glycerol phosphate)、葉綠素、氯化鈉、Callopeptide、甘草酸二鉀、尿囊素、日本扁柏油、硝酸鉀等。
又,填充本發明口腔用組成物的容器亦無特別限
制。可使用例如玻璃製、金屬製、塑膠製或積層型等材質的容器。又,容器的形態亦無特別限制,可使用例如瓶溶器、杯容器、袋容器或管容器等。
以下將具體說明本發明,但本發明並非為下述例所限定者。此外,在下述例所使用之鑽石粒子及二氧化矽粒子分別是從Microdiamant公司及J.M.Huber公司購入。
口腔用組成物之調製
依照下述表1及表2所記載的組成,調製實施例1~12及比較例1~4之口腔用組成物(膏)。具體而言,是將鑽石粒子、二氧化矽粒子、香料、發泡劑(磺基琥珀酸鈉及月桂基硫酸鈉)以外的原料混合,再加入鑽石粒子及二氧化矽粒子並攪拌、均質化,進一步更添加香料並攪拌、均質化,最後,添加發泡劑並在真空下攪拌、均質化(亦兼去泡處理)。此外,表1及表2各成分的數質是表示質量%。
又,二氧化矽粒子是使用市售之2種沉澱二氧化矽。將其等分別令為二氧化矽a粒子及二氧化矽b粒子。該等市售二氧化矽的規格如下述。二氧化矽a粒子的平均粒徑(d50)為3.5~5μm,吸油量(亞麻油吸油量JIS K5101)為30~70(mL/100g)。二氧化矽b粒子的平均粒徑(d50)為6~12μm,吸油量(亞麻油吸油量JIS K5101)為
90~135(mL/100g)。
又,使用之鑽石粒子的平均粒徑(d50)為2.4~3μm(約2.8μm),d10為1.8μm以上,d99為4.5μm以下。
此外,二氧化矽的平均粒徑(d50)是使用低功率He/Ne雷射並使用利用佛朗霍菲繞射原理之Malvern Mastersizer所測得之值。又,鑽石粒子的各累積徑是利用庫爾特計數器Multisizer3(Beckman Coulter股份有限公司製)測得之值。
口腔用組成物之評價
針對獲得之各口腔用組成物,如下述般評價清掃性及平滑性。此外,結果一併顯示在表2。
<清掃性評價方法>
將牛琺瑯質牙片以自動精密切斷機切取縱3mm×横3mm,每1塊2片,以牙科用聚合樹脂(Orthofast樹脂、GC)包埋。
乾燥後,將牙片的表面以自動研磨裝置及研磨紙來鏡面研磨,並以φ1.8mm之測定範圍測定經離子交換水洗淨、乾燥後之初期色差,即L*值、a*值、b*值(色彩色差計CR-24、Konica Minolta Sensing)(分別設為L0、a0、b0)。
將已測定初期色差之上述牙片依序浸漬在0.2M的鹽酸、飽和碳酸鈉水溶液、蒸餾水、1%(v/v)植酸及蒸餾水,藉以浸蝕處理牙片表面。
接著,依照以下順序使色斑附著在浸蝕後的牙片表面。將市售之茶包4袋加入約1.2L的熱水,使之沸騰10分
鐘。使紅茶液回到室溫後,添加3.4g市售之即溶咖啡及2.5g源自豬胃的第II型黏蛋白(Sigma-Aldrich),調製色斑液。
將上述牙片設置在色斑附著裝置,添加上述色斑液並使裝置旋轉,持續5~6天使色斑附著的處理。此外,色斑液為1天交換1次。之後,以在上述色斑液中添加有1g氯化鐵的處理液處理1天或2天直到L*值成為30以下,以離子交換水洗淨及乾燥後,測定色差(L1、a1、b1)。
將已使色斑附著後之牙片安裝於符合ISO標準的刷洗機(brushing machine)。在各實施例及比較例之口腔用組成物的3倍稀釋液(60mL)中,於荷重150g、速度150rpm且來回3,000次的條件下進行刷洗(brushing)後,使牙片乾燥後測定色差(L2、a2、b2)。然後,算出以下式表示之值作為色斑除去力(△E)(小數點以下四捨五入)並予以評價。將該△E作為表示清掃性之值並顯示在表2。
△E=(△E1/△E0)×100
但是,△E1={(L2-L1)2+(a2-a1)2+(b2-b1)2}1/2
△E0={(L2-L0)2+(a2-a0)2+(b2-b0)2}1/2
[亦即,△E1是加總(L2-L1)的平方、(a2-a1)的平方與(b2-b1)的平方之數的平方根;△E0是加總(L2-L0)的平方、(a2-a0)的平方與(b2-b0)的平方之數的平方根。]
<平滑化評價方法>
將牛琺瑯質牙片以自動精密切斷機切取縱3mm×横6mm,每1塊1片,以牙科用聚合樹脂(Orthofast樹脂、GC)
包埋,乾燥後將牙片的表面以自動研磨裝置及研磨紙作鏡面研磨。
之後,將牙片依序以0.2M的鹽酸、蒸餾水、飽和碳酸鈉水溶液、蒸餾水及1%(v/v)植酸浸漬,藉此浸蝕處理牙片表面。
在牙面的一半貼上膠帶(Scotch Brand Tape 10mm,住友3M),保護表面後,安裝到符合ISO標準的刷洗機。在各實施例及比較例之口腔用組成物的3倍稀釋液(60mL)中,於荷重150g、速度150rpm且來回3,000次的條件下進行刷洗。
刷洗後,以形狀測定雷射顯微鏡(VK-8700、Keyence)測定每500μm×500μm之單位面積之算術平均粗度(Ra)並進行評價。此外,令以膠帶保護之面的Ra為測試前Ra,利用下式算出平滑性。
平滑性={(測試前Ra-測試後Ra)/測試前Ra}×100
從上述結果得知,含有鑽石粒子及二氧化矽粒子之本發明口腔用組成物兼備優異的清掃性及平滑性。
於下顯示處方例。此外,在各處方例中是使用下述各鑽石粒子及各二氧化矽粒子。又,摻合量(%)是以質量%表示。
鑽石粒子A:平均粒徑2.8μm(d50)、1.8μm以上(d10)、4.5μm以下(d99)
鑽石粒子B:平均粒徑0.6μm(d50)、0.1μm以上(d10)、2μm以下(d99)
鑽石粒子C:平均粒徑4.9μm(d50)、1.8μm以上(d10)、7μm以下(d99)
鑽石粒子D:平均粒徑2μm(d50)、1μm以上(d10)、4.5μm以下(d99)
鑽石粒子E:平均粒徑2.1μm(d50)、1.3μm以上(d10)、4.5μm以下(d99)
鑽石粒子F:平均粒徑3μm(d50)、1.8μm(d10)、5μm以下(d99)
二氧化矽粒子A:平均粒徑4.5μm(d50)、吸油量52(mL/100g)
二氧化矽粒子B:平均粒徑10.5μm(d50)、吸油量118(mL/100g)
二氧化矽粒子C:平均粒徑3.2μm(d50)、吸油量76(mL/100g)
二氧化矽粒子D:平均粒徑14.5μm(d50)、吸油量146(mL/100g)
二氧化矽粒子E:平均粒徑5.3μm(d50)、吸油量78(mL/100g)
二氧化矽粒子F:平均粒徑6.3μm(d50)、吸油量139(mL/100g)
二氧化矽粒子G:平均粒徑5.1μm(d50)、吸油量28(mL/100g)
二氧化矽粒子H:平均粒徑6.3μm(d50)、吸油量99(mL/100g)
二氧化矽粒子I:平均粒徑3.4μm(d50)、吸油量30(mL/100g)
二氧化矽粒子J:平均粒徑13.3μm(d50)、吸油量94(mL/100g)
成分 摻合量(%)
成分 摻合量(%)
Claims (6)
- 一種口腔用組成物,含有鑽石粒子及二氧化矽粒子。
- 如請求項1之口腔用組成物,其中前述鑽石粒子之平均粒徑(d50)為0.5~5μm。
- 如請求項1或2之口腔用組成物,其中前述二氧化矽粒子之平均粒徑(d50)為0.5~20μm。
- 如請求項1至3中任一項之口腔用組成物,其含有前述鑽石粒子0.01~0.5質量%。
- 如請求項1至4中任一項之口腔用組成物,其中前述二氧化矽粒子係由第1二氧化矽粒子與第2二氧化矽粒子之組合所構成,該第1二氧化矽粒子之平均粒徑(d50)為3~5.5μm且吸油量為20~80(mL/100g),第2二氧化矽粒子之平均粒徑(d50)為6~15μm且吸油量為90~150(mL/100g)之。
- 如請求項1至5中任一項之口腔用組成物,其相對於前述鑽石粒子0.01~0.5質量份,含有前述二氧化矽粒子1~35質量份。
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JP2004238321A (ja) * | 2003-02-05 | 2004-08-26 | Kao Corp | 口腔用組成物 |
JP2007091636A (ja) * | 2005-09-29 | 2007-04-12 | Gc Corp | 歯科研磨用組成物 |
AU2006330547B2 (en) * | 2005-12-21 | 2011-01-27 | Colgate-Palmolive Company | Cleaning and/or polishing compositions and methods for use thereof |
US8986659B2 (en) * | 2007-11-16 | 2015-03-24 | Wam Oral Care Products, LLC | Diamond, precious and semi-precious dust polishing agent for dental veneers and teeth |
CA2778544C (en) * | 2008-11-27 | 2016-07-26 | Amc Abrasives Marketing & Consulting Llp | Dental care products with diamond particles |
PL2361120T3 (pl) * | 2008-11-27 | 2016-01-29 | Amc Abrasives Marketing & Consulting Llp | Dentystyczne pielęgnujące produkty z diamentowymi cząstkami |
US9724541B2 (en) * | 2009-04-06 | 2017-08-08 | Lisa Marie Kao | Dental cleaning and polishing composition comprising diamond particles |
-
2014
- 2014-06-05 JP JP2015521481A patent/JP6367190B2/ja active Active
- 2014-06-05 CN CN201480032611.2A patent/CN105263464B/zh active Active
- 2014-06-05 WO PCT/JP2014/064933 patent/WO2014196591A1/ja active Application Filing
- 2014-06-05 US US14/895,301 patent/US20160120769A1/en not_active Abandoned
- 2014-06-05 CA CA2914211A patent/CA2914211A1/en not_active Abandoned
- 2014-06-05 EP EP14808142.5A patent/EP3006012A4/en not_active Withdrawn
- 2014-06-06 TW TW103119719A patent/TW201534328A/zh unknown
Also Published As
Publication number | Publication date |
---|---|
CA2914211A1 (en) | 2014-12-11 |
WO2014196591A1 (ja) | 2014-12-11 |
CN105263464B (zh) | 2018-03-06 |
CN105263464A (zh) | 2016-01-20 |
JP6367190B2 (ja) | 2018-08-01 |
US20160120769A1 (en) | 2016-05-05 |
EP3006012A1 (en) | 2016-04-13 |
EP3006012A4 (en) | 2016-11-30 |
JPWO2014196591A1 (ja) | 2017-02-23 |
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