TW201517798A - Fungicidal composition and the use thereof - Google Patents
Fungicidal composition and the use thereof Download PDFInfo
- Publication number
- TW201517798A TW201517798A TW103137724A TW103137724A TW201517798A TW 201517798 A TW201517798 A TW 201517798A TW 103137724 A TW103137724 A TW 103137724A TW 103137724 A TW103137724 A TW 103137724A TW 201517798 A TW201517798 A TW 201517798A
- Authority
- TW
- Taiwan
- Prior art keywords
- pyraclostrobin
- fungicidal
- copper sulfate
- active compound
- copper
- Prior art date
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- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
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- ZXGOACRTCPRVON-UHFFFAOYSA-K trisodium;2-sulfonatobutanedioate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(C([O-])=O)S([O-])(=O)=O ZXGOACRTCPRVON-UHFFFAOYSA-K 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/10—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
- A01N47/24—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof containing the groups, or; Thio analogues thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/10—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/06—Aluminium; Calcium; Magnesium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/16—Heavy metals; Compounds thereof
- A01N59/20—Copper
Landscapes
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Inorganic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Description
本發明涉及一種含有吡唑醚菌酯的改良殺真菌組成物。該組成物尤其適用於預防和控制植物病原真菌和細菌。 The present invention relates to an improved fungicidal composition comprising pyraclostrobin. The composition is especially useful for the prevention and control of phytopathogenic fungi and bacteria.
在園藝作物和旱作生產中，作物會遇到多種真菌或細菌的感染而得各種疾病，也常因土壤裡多種致病或腐生的真菌(如腐黴、疫黴、立枯絲核菌、鐮刀菌、灰黴菌等)和細菌(軟腐菌等)的感染，引起爛種、爛根、死苗。 In horticultural crops and dry farming, crops are infected with a variety of fungi or bacteria, resulting in a variety of diseases, often due to a variety of pathogenic or saprophytic fungi in the soil (such as Pythium, Phytophthora, Rhizoctonia solani, Infection of Fusarium, Botrytis, etc. and bacteria (soft rot fungi, etc.) causes rotten seeds, rotten roots, and dead seedlings.
殺真菌劑是天然或合成的化合物，用於保護植物不受真菌感染。目前的農業方法對殺真菌劑的使用十分依賴。實際上，如果不使用殺真菌劑，一些農作物不能有效地生長。使用殺真菌劑，農民可以增加作物產量和品質，從而提高作物價值。多數情況下，作物的附加值至少是使用殺真菌劑支出的三倍。 Fungicides are natural or synthetic compounds used to protect plants from fungal infections. Current agricultural methods are highly dependent on the use of fungicides. In fact, some crops cannot grow efficiently without the use of fungicides. With fungicides, farmers can increase crop yields and quality, thereby increasing crop value. In most cases, the added value of the crop is at least three times that of the fungicide.
但是，沒有一種殺真菌劑適用於所有情況。另外，重複使用同一款殺真菌劑會導致此類殺真菌劑或其他相關類型的殺真菌劑產生抗藥性。因此，正在研究生產更安全、性能更高、成本更低、劑量更少及使用更方便的殺真菌劑和殺真菌劑組成物。 However, none of the fungicides are suitable for all situations. In addition, repeated use of the same fungicide can result in resistance to such fungicides or other related types of fungicides. Therefore, fungicide and fungicide compositions which are safer to produce, higher in performance, lower in cost, less in dosage, and more convenient to use are being investigated.
當兩種或以上化合物的活性大於單獨使用各化合物的活性總和時，即稱之為協同作用。 When the activity of two or more compounds is greater than the sum of the activities of the respective compounds used alone, it is called synergistic action.
本發明的目的是提供一種能有效抑制有害真菌和細菌的耕作方法及組成物，以減少用藥劑量及/或增強活性譜及/或解決抗藥性管理的問題。 It is an object of the present invention to provide a method and composition for effectively inhibiting harmful fungi and bacteria to reduce the amount of the drug and/or enhance the spectrum of activity and/or to address the problem of drug resistance management.
吡唑醚菌酯(Pyraclostrobin)，是一種已知的殺真菌活性化合物，其化學名稱為：甲基N-{2-[1-(4-氯苯基)-1H-吡唑-3-基氧甲基]苯基}(N-甲氧)胺基甲酸酯，其結構式為：
吡唑醚菌酯和其他的合成甲氧丙烯酸酯(strobin)類似物的作用機理一樣，是一種粒腺體呼吸抑制劑。它通過阻止細胞色素b和Cl間電子傳遞而抑制粒腺體呼吸作用，使粒腺體不能產生和提供細胞正常代謝所需要的能量(ATP)，最終導致細胞死亡。吡唑醚菌酯具有較強的抑制病菌孢子萌發能力，對葉片內菌絲生長有很好的抑制作用，其持效期較長，並且具有潛在的治療活性。該化合物在葉片內向葉尖或葉基傳導及薰蒸作用較弱，但在植物體內的傳導活性較強。同時它又是一種激素型殺真菌劑，能使作物吸收更多的氮，促進作物的生長。簡言之，伴隨較廣的應用範圍，吡唑醚菌酯具有保護功能、治療功能、內吸傳導性和耐雨水沖刷性能。 Pyraclostrobin and other synthetic strobin analogs have the same mechanism of action as a granular glandular respiratory inhibitor. It inhibits granulocyte respiration by preventing electron transfer between cytochrome b and Cl, rendering the granule gland unable to produce and provide the energy (ATP) required for normal cell metabolism, ultimately leading to cell death. Pyraclostrobin has strong ability to inhibit the spore germination of the pathogen, and has a good inhibitory effect on the mycelial growth in the leaves. It has a long-lasting effect and has potential therapeutic activity. The compound has weaker conduction and fumigation in the leaves to the tip or leaf base, but has stronger conductive activity in plants. At the same time, it is a hormonal fungicide that allows crops to absorb more nitrogen and promote crop growth. In short, with a wide range of applications, pyraclostrobin has protective, therapeutic, systemic, and rain-resistant properties.
吡唑醚菌酯適宜作物主要用於預防和控制小麥、水稻、花生、葡萄、蔬菜、香蕉、擰檬、咖啡、果樹、核桃、茶樹、煙草、觀賞植物、草坪及其他大田作物上的病害。預防和控制對象可有效地預防和控制由子囊菌 綱、擔子菌綱、半知菌類和卵菌綱真菌引起的葉枯病、銹病、白粉病、霜黴病、疫病、炭疽病、黑星病、葉斑病、瘡痂病、褐斑病、立枯病等多種病害。由於吡唑醚菌酯對預防和控制穀類作物病害具有廣譜的殺真菌活性，因此能顯著預防和控制谷類的葉部和穗粒的病害及大幅增加產量。對作物安全性該化合物不僅毒性低，對非靶標生物安全，而且對使用者和環境均安全友好。大部分試驗結果證明，按照推薦劑量使用吡唑醚菌酯不會對作物產生藥害。但對極個別品種的北美葡萄和李子在特定生長期有藥害。 Pirazolidyl suitable crops are mainly used to prevent and control diseases on wheat, rice, peanuts, grapes, vegetables, bananas, lemons, coffee, fruit trees, walnuts, tea trees, tobacco, ornamental plants, lawns and other field crops. Prevention and control objects can effectively prevent and control Ascomycetes Leaf blight, rust, powdery mildew, downy mildew, blight, anthracnose, black spot, leaf spot, scab, brown spot, and leg dung caused by fungi, basidiomycetes, deuteromycetes and oomycetes Blight and other diseases. Since pyraclostrobin has a broad spectrum of fungicidal activity for preventing and controlling cereal crop diseases, it can significantly prevent and control the diseases of leaves and ears of cereals and greatly increase the yield. For crop safety This compound is not only less toxic, safe for non-target organisms, but also safe and user friendly to the environment. Most of the test results show that the use of pyraclostrobin at the recommended dosage does not cause phytotoxicity to the crop. However, very few varieties of North American grapes and plums have phytotoxicity in certain growth stages.
由於現在對殺真菌劑的環境要求和經濟要求持續提高，例如對活性譜、毒性、選擇性、施用率、殘餘物組成和有利的製備可行性的要求，此外還由於在例如抗藥性方面可能存在問題，因此，開發在某些方面優於現有殺真菌劑的新的殺真菌劑是持續的任務。因此，有必要研發含有吡唑醚菌酯的改進合成物。 Due to the current increasing environmental and economic requirements for fungicides, such as requirements for activity profile, toxicity, selectivity, application rate, residue composition and advantageous preparation feasibility, in addition to possible resistance in, for example, resistance to chemicals The problem, therefore, is to continue to develop new fungicides that are superior in some respects to existing fungicides. Therefore, it is necessary to develop an improved composition containing pyraclostrobin.
硫酸銅鈣(Copper Calcium Sulphate)，商品名叫做「多寧(duoning)」，為非選擇性含銅離子之保護性殺真菌劑，具低毒性，相當於工業化生產的波爾多粉(bordeaux powder)，但噴施後對葉面沒有藥斑污染。硫酸銅鈣係藉由釋放的銅離子與病原真菌或細菌體內的多種生物基團結合，形成銅的絡合物等物質，使蛋白質變性，從而阻礙和抑制代謝，導致病菌死亡。獨特的銅鈣化合物遇水時緩慢釋放出殺真菌的銅離子，與病菌的萌發、侵染同步。殺菌、預防疾病可同時達成。該化合物對真菌性與細菌性病害的預防與控制皆有效。硫酸銅鈣與普通波爾多液不同，藥液呈微酸性，可與不含金屬離子的非鹼性藥劑混用，使用方便。硫酸銅鈣顆粒微細，呈絨毛狀結構，噴施後能均勻分佈並緊密粘附在作物的葉片表面，耐雨水沖刷能力強。另外，硫酸銅鈣富含12%的硫酸鈣，在預防和控制病害的同時，還具有相當的補鈣功效。 Copper Calcium Sulphate, trade name "duoning", is a non-selective copper-ion-protective fungicide with low toxicity, equivalent to industrially produced bordeaux powder. However, there was no contamination of the leaf surface after spraying. Copper sulphate is formed by binding copper ions to various biological groups in pathogenic fungi or bacteria to form a complex such as copper, which denatures proteins, thereby hindering and inhibiting metabolism, leading to the death of germs. The unique copper-calcium compound slowly releases fungicidal copper ions when it meets water, which is synchronous with the germination and infection of the bacteria. Sterilization and disease prevention can be achieved at the same time. The compound is effective for the prevention and control of both fungal and bacterial diseases. Calcium copper sulfate is different from ordinary Bordeaux mixture. The liquid is slightly acidic and can be mixed with non-alkaline agents without metal ions. It is convenient to use. The calcium sulphate granules are fine and have a fluffy structure. They can be evenly distributed after spraying and adhere closely to the leaf surface of the crop, and have strong ability to withstand rain. In addition, copper calcium sulphate is rich in 12% calcium sulphate, and it has considerable calcium supplementation while preventing and controlling diseases.
基於其廣譜，硫酸銅鈣殺真菌劑、硫酸銅鈣不易誘發病原真菌產生抗藥性。對所有真菌性和細菌性病害都有良好效果。可廣泛應用於對銅離子 不敏感的多種果樹、多種蔬菜以及多種經濟作物以預防和控制多種真菌性與細菌性病害，如多種落葉果樹的枝幹病害；蘋果褐斑病、柑橘的潰瘍病、瘡痂病、炭疽病；煙草的野火病赤心病；葡萄的霜黴病、炭疽病、褐斑病、黑痘病；棗樹的銹病、輪紋病、炭疽病、褐斑病；梨樹的黑星病、褐斑病；生薑的爛脖子病(腐黴莖基腐病)、薑瘟病；大蒜的根腐病、軟腐病；馬鈴薯的晚疫病以及其他多種瓜果蔬菜的疫病、猝倒病、立枯病、霜黴病、晚疫病、真菌性葉斑病、細菌性葉斑病等。 Based on its broad spectrum, copper copper calcium fungicide and copper calcium sulfate are not easy to induce resistance to pathogenic fungi. Good for all fungal and bacterial diseases. Can be widely used for copper ions Insensitive to a variety of fruit trees, a variety of vegetables and a variety of cash crops to prevent and control a variety of fungal and bacterial diseases, such as a variety of deciduous fruit tree stem disease; apple brown spot, citrus canker, scab, anthracnose; tobacco Wildfire disease, brown heart disease; grape downy mildew, anthracnose, brown spot, black pox; rust of jujube, ring rot, anthracnose, brown spot; black spot disease of pear tree, brown spot; Ginger's rotten neck disease (Pythium stem rot), ginger rickets; garlic root rot, soft rot; potato late blight and other diseases of various fruits and vegetables, squatting, blight, downy mildew Disease, late blight, fungal leaf spot, bacterial leaf spot, etc.
出人意料地，吡唑醚菌酯和硫酸銅鈣組合物對真菌和細菌具有很高的活性。尤其是吡唑醚菌酯和硫酸銅鈣組合物具有協同作用。 Surprisingly, the pyraclostrobin and calcium copper sulphate compositions are highly active against fungi and bacteria. In particular, the pyraclostrobin and calcium copper sulfate compositions have a synergistic effect.
因此，本發明提供一種包括吡唑醚菌酯和硫酸銅鈣的殺真菌活性化合物。 Accordingly, the present invention provides a fungicidally active compound comprising pyraclostrobin and calcium copper sulfate.
據發現，所述新的殺真菌活性化合物組合物具有很好的殺真菌和細菌性能，該組合物包括吡唑醚菌酯和硫酸銅鈣。 The novel fungicidal active compound composition was found to have good fungicidal and bacterial properties, and the composition includes pyraclostrobin and copper copper sulfate.
出人意料地，本發明的殺真菌活性化合物組合物的殺真菌活性明顯高於單個殺真菌活性化合物的活性總和。活性化合物的活性的加和明顯更高。 Surprisingly, the fungicidal activity of the fungicidal active compound compositions of the invention is significantly higher than the sum of the activities of the individual fungicidal active compounds. The sum of the activities of the active compounds is significantly higher.
當殺真菌活性化合物組合物按照本發明中殺真菌組成物的一定重量比製備，則協同作用特別明顯。但是，殺真菌組成物中的殺真菌活性化合物組成物的重量比可在一定範圍內變化。 Synergistic effects are particularly pronounced when the fungicidal active compound composition is prepared in a weight ratio of the fungicidal composition of the invention. However, the weight ratio of the fungicidal active compound composition in the fungicidal composition may vary within a certain range.
本發明是一種殺真菌活性化合物組合物，其特徵在於：包含吡唑醚菌酯和硫酸銅鈣，其中吡唑醚菌酯和硫酸銅鈣的重量比1：100至100：1，較佳1：50至50：1，更佳1：25至25：1，更佳1：15至15：1，最佳1：10至10：1或者較佳1：5至5：1。 The present invention is a fungicidal active compound composition characterized by comprising pyraclostrobin and copper copper sulfate, wherein the weight ratio of pyraclostrobin and copper calcium sulfate is 1:100 to 100:1, preferably 1 : 50 to 50:1, more preferably 1:25 to 25:1, more preferably 1:15 to 15:1, most preferably 1:10 to 10:1 or preferably 1:5 to 5:1.
一種製備殺真菌組成物的方法，將所述的殺真菌活性化合物組合物與填充劑和/或表面活性劑混合。 A method of preparing a fungicidal composition, which comprises mixing the fungicidal active compound composition with a filler and/or a surfactant.
所述的殺真菌組合物的調配物為懸浮劑、種衣劑、可濕性粉劑、水分散粒劑、微囊懸浮劑、包衣顆粒劑、顆粒劑、乳劑、微乳劑、水基乳劑、 泡騰片。 The formulation of the fungicidal composition is a suspending agent, a seed coating agent, a wettable powder, a water-dispersible granule, a microcapsule suspension agent, a coated granule, a granule, an emulsion, a microemulsion, a water-based emulsion, Effervescent tablets.
在所述的殺真菌組成物中，吡唑醚菌酯和硫酸銅鈣殺真菌活性化合物組合物的重量占殺真菌組合物的5至90%，較佳10至90%，更佳20至90%，再佳20至80%，再更佳30至80%。 In the fungicidal composition, the pyraclostrobin and copper calcium sulphate fungicidal active compound compositions comprise from 5 to 90%, preferably from 10 to 90%, more preferably from 20 to 90% by weight of the fungicidal composition. %, better 20 to 80%, and even better 30 to 80%.
一種預防和控制植物病原細菌的方法，將殺真菌組成物作用於致細菌和/或其生存環境，或者植物、植物部位、種子、土壤、區域、材料或空間中。 A method of preventing and controlling phytopathogenic bacteria which acts on a bacterium and/or its living environment, or a plant, plant part, seed, soil, area, material or space.
一種預防和控制植物病原細菌的方法，將吡唑醚菌酯和硫酸銅鈣同時施用、或分別施用、或相繼施用。 A method for preventing and controlling phytopathogenic bacteria, wherein pyraclostrobin and copper calcium sulphate are applied simultaneously, or separately, or sequentially.
所述的殺真菌活性化合物組合物用於預防和控制真菌和細菌的用途。所述的殺真菌組合物用於預防和控制真菌和細菌的用途。 The use of the fungicidal active compound composition for the prevention and control of fungi and bacteria. The fungicidal compositions are useful for the prevention and control of fungi and bacteria.
所述的殺真菌活性化合物組合物用於預防和控制穀類、水果、蔬菜、經濟作物上真菌和細菌的用途。所述的殺真菌化合物組合物用於預防和控制穀類、水果、蔬菜、經濟作物上真菌和細菌的用途。 The fungicidal active compound composition is useful for preventing and controlling fungi and bacteria on cereals, fruits, vegetables, cash crops. The fungicidal compound composition is useful for preventing and controlling fungi and bacteria on cereals, fruits, vegetables, cash crops.
本發明的殺真菌活性化合物組合物具有有效的殺微生物活性，並且可在作物保護或材料保護中用於預防和控制不想要的微生物，如真菌和細菌。 The fungicidal active compound compositions of the present invention have potent microbicidal activity and can be used in crop protection or material protection to prevent and control unwanted microorganisms such as fungi and bacteria.
本發明的殺真菌活性化合物組合物具有非常好的殺真菌性能，並可被用於預防和控制植物病原真菌，如根腫菌綱(plasmodiophoromycetes)、卵菌綱(oomycetes)、壺菌綱(chytridiomycetes)、接和菌綱(zygomycetes)、子囊菌綱(ascomycetes)、擔子菌綱(basidiomycetes)、半知菌綱(deuteromycetes)等。 The fungicidal active compound composition of the invention has very good fungicidal properties and can be used for the prevention and control of phytopathogenic fungi, such as plasmodiophoromycetes, oomycetes, chytridiomycetes. ), zygomycetes, ascomycetes, basidiomycetes, deuteromycetes, and the like.
本發明的殺真菌活性化合物組合物具有對抗真菌之非常好的殺真菌性能，並可被用於預防和控制植物病原細菌。如假單胞菌科、根瘤菌科、腸桿菌科、棒桿菌科以及鏈黴菌科。 The fungicidal active compound composition of the present invention has very good fungicidal properties against fungi and can be used for the prevention and control of phytopathogenic bacteria. Such as Pseudomonas, Rhizobium, Enterobacteriaceae, Corynebacterium and Streptomyces.
作為實例但非限制的方式提出的歸入上述大類的一些導致真菌病害和細菌病害的病原體：由白粉病病原體引起的病害，病原體如布氏白粉菌屬(Blumeria)菌種； 由銹病病原體引起的病害的病原體如膠鏽菌屬(Gymnosporangium)菌種；由卵菌綱類(Oomycetes)病原體引起的病害，病原體如霜黴屬(peronospora)菌種；由葉斑病和葉萎縮病病害病原體引起的病害，病原體如鏈格孢屬(Alternaria)菌種；引起根和莖病害的病原體引起的病害，病原體如鐮孢屬菌(Fusarium)種；引起肉穗花序和散穗花序病害的病原體，病原體如鏈格孢屬(Alternaria)菌種；由黑粉菌引起的病害的病原體，病原體如黑粉菌(Ustilago)屬種；引起果實腐爛的病原體，病原體如青黴屬(Penicillium)菌種；引起種傳和土傳的腐爛和萎縮病害以及幼苗病害的病原體，病原體如疫黴菌屬(Phytophthora)菌種；引起萎縮病的病原體，病原體如鏈核盤(Monilinia)菌屬；引起葉、花和果實畸形的病原體，病原體如外囊菌屬菌(Taphrina)菌種；引起癌症病害、菌癭和掃帚病害的病原體，病原體如叢赤殼屬(Nectria)菌種；引起木本植物的退化病害的病原體，病原體如Esca菌種；起花和種子病害的病原體，病原體如葡萄孢屬(botrytis)菌種；因為植物塊莖病害的病原體，病原體如絲核菌屬(Rhizoctonia)菌種；本發明的殺真菌活性化合物組合物還顯示出對植物具有很強的刺激作用(stimulating effect)。因此，它們適用於動員植物的內部防禦以抵抗有害微生物的攻擊。在本文中，植物刺激(抗性誘導)化合物可被理解為能夠刺激植物的防禦系統，使得當被處理的植物在後來接種有害微生物時能顯示出對這些微生物的顯著的抗性的物質。 Some pathogens causing fungal diseases and bacterial diseases classified as the above-mentioned broad categories, as exemplified but not limited: diseases caused by powdery mildew pathogens, pathogens such as Blumeria ; caused by rust pathogens Disease pathogens such as Gymnosporangium ; diseases caused by Oomycetes pathogens, pathogens such as peronospora; caused by leaf spot and leaf atrophy pathogens diseases, such as Alternaria pathogens (of Alternaria) species; diseases caused root and stem diseases caused by pathogens, such as Fusarium pathogens (of Fusarium) inoculum; spadix cause ear inflorescence and bulk of disease pathogens, pathogens such as Alternaria (of Alternaria) species; disease caused by a pathogen Ustilago, such as pathogen Ustilago (Ustilago) species; pathogens cause fruit rot, pathogens such as Penicillium (Penicillium) species; cause seed-borne and soil-borne diseases and atrophy rot pathogens and seedling diseases, pathogens such as Phytophthora spp (of Phytophthora) species; wasting disease caused by Pathogens, such as Monilinia pathogen (Monilinia) species; induced leaves, flowers and fruit malformation pathogens, bacterial pathogens, such as the genus external capsule (Taphrina) species; diseases caused by cancer, and pathogen broom gall disease, pathogens such as Nectria species; pathogens causing degenerative diseases of woody plants, pathogens such as Esca; pathogens of flowering and seed diseases, pathogens such as botrytis; species of tuber disease Pathogens, pathogens such as Rhizoctonia species; the fungicidal active compound compositions of the present invention also exhibit a strong stimulating effect on plants. Therefore, they are suitable for mobilizing the internal defense of plants against attack by harmful microorganisms. In the present context, a plant stimulating (resistance-inducing) compound can be understood as a substance capable of stimulating a plant's defense system such that the plant to be treated exhibits significant resistance to these microorganisms when subsequently inoculated with harmful microorganisms.
本發明中，有害微生物應被理解為令植物病原的真菌和細菌。因此， 本發明的殺真菌活性化合物組合物可用於在進行了針對所提及的病原菌攻擊的處理後一定時間內保護植物。這種保護所達到的一段時間通常為從使用殺真菌活性化合物組合物處理開始計算的1至10天，較佳1至7天。 In the present invention, harmful microorganisms are to be understood as fungi and bacteria which cause plant pathogens. therefore, The fungicidal active compound compositions of the invention can be used to protect plants for a certain period of time after treatment with the mentioned pathogen attack. The period of time for such protection is typically from 1 to 10 days, preferably from 1 to 7 days, calculated from the treatment with the fungicidal active compound composition.
本發明的殺真菌活性化合物組合物特別適用於預防和控制黴菌、葉斑病、果實和花的腐爛、貯藏病害和由麯黴屬真菌/青黴菌等引起的繼發感染 The fungicidal active compound composition of the invention is particularly suitable for the prevention and control of mold, leaf spot, fruit and flower rot, storage diseases and secondary infection caused by Aspergillus fungus/penicillium
本發明的殺真菌活性化合物組合物特別適用於葡萄栽培、水果栽培、作物種植、蔬菜栽培和豆科植物種植。 The fungicidal active compound compositions of the present invention are particularly useful for viticulture, fruit cultivation, crop cultivation, vegetable cultivation, and legume planting.
本發明的殺真菌活性化合物組合物在預防和控制植物病害所需濃度下具有良好的植物耐受性，這使得可對植物的地上部分、離體繁殖株、種子以及土壤進行處理。本發明的殺真菌活性化合物組合物還可以葉面施用或者用於種子處理。 The fungicidal active compound composition of the present invention has good plant tolerance at the concentrations required for the prevention and control of plant diseases, which allows the treatment of aerial parts of plants, exudates, seeds and soil. The fungicidal active compound compositions of the invention may also be applied foliar or for seed treatment.
依據本發明，均可處理所有的植物及植物部位。本發明的植物的含義應被理解為所有的植物及植物種群，例如需要的及不需要的野生植物或作物植物(包括自然存在的作物植物)。作物植物可以是通過常規育種或優選法或通過生物技術和遺傳工程方法或者通過所述方法的結合而獲得的植物，包括轉基因植物，也包括受植物種苗權保護或不受其保護的植物栽培種。植物部位的含義應被理解為植物所有的地上及地下部位及器官，例如芽、葉、花和根，可列舉的實例有葉、針葉、莖、幹、花、子實體、果實、種子、根、塊莖以及根莖。植物部位還包括採收物，以及無性與有性繁殖物，例如秧苗、塊莖、根莖、插條和種子。 According to the invention, all plants and plant parts can be treated. The meaning of the plants of the invention is to be understood as meaning all plants and plant populations, such as desired and undesired wild plants or crop plants (including naturally occurring crop plants). The crop plants may be plants obtained by conventional breeding or preferred methods or by biotechnological and genetic engineering methods or by a combination of the methods, including transgenic plants, as well as plant cultivars protected or unprotected by plant seedling rights. The meaning of plant parts should be understood as all above-ground and underground parts and organs of plants, such as buds, leaves, flowers and roots. Examples include leaves, needles, stems, stems, flowers, fruiting bodies, fruits, seeds, Roots, tubers and rhizomes. Plant parts also include harvested material, as well as vegetative and generative propagation material such as seedlings, tubers, rhizomes, cuttings and seeds.
根據本發明使用殺真菌活性化合物組合物對植物和植物部位進行的處理，通過常規方法直接進行，或通過作用於其所處環境、生境、或儲存區域來實現，所述常規處理方法例如浸液、噴霧、蒸發、彌霧、撒播或塗抹，並且，對繁殖物，尤其是種子，還可以塗抹一層或多層。 The treatment of plants and plant parts using the fungicidal active compound composition according to the invention is carried out directly by conventional methods or by acting on the environment, habitat, or storage area in which it is applied, such as infusion Spray, evaporate, mist, spread or spread, and apply one or more layers to the propagation material, especially the seed.
本發明的殺真菌活性化合物組合物可轉化為常規製劑，例如懸浮劑、種衣劑、可濕性粉劑、水分散粒劑、微囊懸浮劑、包衣顆粒劑、顆粒劑、 乳劑、微乳劑、水基乳劑、泡騰片。 The fungicidal active compound composition of the present invention can be converted into a conventional preparation, such as a suspension, a seed coating, a wettable powder, a water-dispersible granule, a microcapsule suspension, a coated granule, a granule, Emulsions, microemulsions, water-based emulsions, effervescent tablets.
本發明所述的一種殺真菌組成物包含殺真菌活性化合物吡唑醚菌酯和硫酸銅鈣。所述的殺真菌組成物中，殺真菌活性化合物吡唑醚菌酯和硫酸銅鈣與填充劑和/或表面活性劑混合。 A fungicidal composition according to the invention comprises the fungicidal active compound pyraclostrobin and calcium copper sulphate. In the fungicidal composition, the fungicidal active compound pyraclostrobin and calcium copper sulfate are mixed with a filler and/or a surfactant.
根據本發明，術語“填充劑”指可與殺真菌活性化合物組合物相組合或聯合以使其更易於施用給對象(例如植物、作物或草類)的天然或合成的有機或無機化合物。因此，所述填充劑較佳為惰性的，至少應為農業可接受的。所述填充劑可以為固體或液體。 According to the invention, the term "filler" refers to a natural or synthetic organic or inorganic compound which can be combined or combined with a fungicidal active compound composition to make it easier to apply to a subject, such as a plant, crop or grass. Therefore, the filler is preferably inert and at least agriculturally acceptable. The filler may be a solid or a liquid.
本發明中可以使用的非活性媒介既可以是固體也可以是液體的，可以作為固體媒介材料使用的有例如：植物質粉末類(例如大豆粉、澱粉、穀物粉、木粉、樹皮粉、鋸末、核桃殼粉、麩皮、纖維素粉末、椰殼、玉米穗軸和煙草莖的顆粒，提取植物精華後的殘渣等)、紙張、鋸末、黏土類(例如高嶺土、皂土、酸性瓷土等)、滑石粉類。矽石類(例如矽藻土、矽砂、雲母、含水矽酸，矽酸鈣)、活性炭、天然礦物質類(浮石、綠坡縷石及沸石等)、燒制矽藻土、砂、塑膠媒介等(例如聚乙烯、聚丙烯、聚偏二氯乙烯等)、氯化鉀、碳酸鈣、磷酸鈣等的無機礦物性粉末、硫酸銨、磷酸銨、尿素、綠化銨等的化學肥料、土肥，這些物質可以單獨使用或者混合使用。 The non-reactive medium which can be used in the present invention can be either solid or liquid, and can be used as a solid medium material such as: vegetable powder (for example, soy flour, starch, cereal flour, wood flour, bark flour, sawdust). , walnut shell powder, bran, cellulose powder, coconut shell, corn cob and tobacco stem granules, residue after extracting plant extracts, etc.), paper, sawdust, clay (such as kaolin, bentonite, acid china clay, etc.) , talcum powder. Vermiculite (such as diatomaceous earth, strontium sand, mica, hydrous citrate, calcium citrate), activated carbon, natural minerals (pumice, attapulgite and zeolite), fired algae, sand, plastic Inorganic mineral powder such as medium (such as polyethylene, polypropylene, polyvinylidene chloride, etc.), potassium chloride, calcium carbonate, calcium phosphate, etc., chemical fertilizer such as ammonium sulfate, ammonium phosphate, urea, green ammonium, etc. These materials may be used singly or in combination.
可以作為液體媒介材料使用的可以在下列材料中選擇，例如水，酒精類(例如甲醇、乙醇、異丙醇、丁醇、乙二醇等)、酮類(例如丙酮、甲基乙基酮、二異丁基甲酮、環己酮等)、醚類(例如***、二烷、甲基纖維素、四氫呋喃等)、脂肪族碳氫化合物類(例如煤油、礦物油等)、芳香族碳氫化合物類(例如苯、甲苯、二甲苯、溶劑油、烷基萘、氯代芳烴、氯代脂肪烴、氯苯，等)、鹵化碳氫化合物類、醯胺類、碸類、二甲基亞碸、礦物和植物油、動物油等。 It can be used as a liquid medium material, and can be selected from the following materials, such as water, alcohol (such as methanol, ethanol, isopropanol, butanol, ethylene glycol, etc.), ketones (such as acetone, methyl ethyl ketone, Diisobutyl ketone, cyclohexanone, etc.), ethers (such as ether, two Alkane, methyl cellulose, tetrahydrofuran, etc.), aliphatic hydrocarbons (such as kerosene, mineral oil, etc.), aromatic hydrocarbons (such as benzene, toluene, xylene, mineral spirits, alkyl naphthalene, chlorinated Aromatic hydrocarbons, chlorinated aliphatic hydrocarbons, chlorobenzenes, etc.), halogenated hydrocarbons, guanamines, anthraquinones, dimethyl hydrazine, mineral and vegetable oils, animal oils, and the like.
為使活性化合物乳化、分散、可溶化、以及/或者潤濕可以使用表面活 性劑例如可以列舉脂肪醇聚氧乙烯醚、聚氧乙烯烷基芳基醚、聚氧乙烯高級脂肪酸酯、聚氧乙烯醇或酚的磷酸酯、多元醇的脂肪酸酯、烷芳基磺酸鈉、萘磺酸聚合物、木質素磺酸鹽、高分子梳形的支裝共聚物、丁基萘磺酸鹽、烷基芳基磺酸鹽、烷基磺基琥珀酸鈉、油脂、脂肪醇與環氧乙烷縮合物、烷基牛磺酸鹽等聚丙烯酸鹽、蛋白質水解物。合適的低聚糖物或聚合物，例如基於單獨的乙烯單體、丙烯酸、環氧乙烷和/或環氧丙烷(EO和/或PO)或者其與例如(多元)醇或(多元)胺的結合。 Surface activity can be used for emulsifying, dispersing, solubilizing, and/or wetting the active compound Examples of the agent include fatty alcohol polyoxyethylene ether, polyoxyethylene alkyl aryl ether, polyoxyethylene higher fatty acid ester, polyoxyethylene alcohol or phenol phosphate, fatty acid ester of polyhydric alcohol, and alkylaryl sulfonate. Sodium, naphthalenesulfonic acid polymer, lignosulfonate, polymeric comb-shaped branched copolymer, butyl naphthalenesulfonate, alkylarylsulfonate, sodium alkylsulfosuccinate, fat, A polyacrylate such as a fatty alcohol condensate with ethylene oxide or an alkyl taurate or a protein hydrolyzate. Suitable oligosaccharides or polymers, for example based on ethylene monomers alone, acrylic acid, ethylene oxide and/or propylene oxide (EO and/or PO) or with, for example, (poly)alcohols or (poly)amines Combination of.
為使活性化合物分散穩定化、附著以及/或者結合，可使用例如黃原膠、矽酸鎂鋁、明膠、澱粉、纖維素甲醚、聚乙烯醇、聚乙酸乙烯酯和天然磷脂(如腦磷脂和卵磷脂)以及合成磷脂、皂土、木質素磺酸鈉等輔助劑。其中防凍劑可選用乙二醇，丙二醇，丙三醇，山梨醇。 For stabilizing, adhering and/or binding the active compound, for example, xanthan gum, magnesium aluminum silicate, gelatin, starch, cellulose methyl ether, polyvinyl alcohol, polyvinyl acetate and natural phospholipids such as cephalin can be used. And lecithin) and auxiliary agents such as synthetic phospholipids, bentonite, sodium lignosulfonate. Among them, antifreeze can be selected from ethylene glycol, propylene glycol, glycerin, and sorbitol.
作為懸浮性產品的抗絮凝劑可以使用例如萘磺酸聚合物、聚合磷酸鹽等的輔助劑。 As the deflocculating agent of the suspension product, an auxiliary agent such as a naphthalenesulfonic acid polymer or a polymeric phosphate can be used.
作為消泡劑可使用有機矽消泡劑。 As the antifoaming agent, an organic antifoaming agent can be used.
可以使用的著色劑，例如無機顏料，如氧化鐵、氧化鈦和普魯士藍；以及有機顏料/染料：茜素染料、偶氮染料和金屬酞菁染料；以及微量元素，例如鐵鹽、錳鹽、硼鹽、銅鹽、鈷鹽、鉬鹽和鋅鹽。 Coloring agents which can be used, such as inorganic pigments such as iron oxide, titanium oxide and Prussian blue; and organic pigments/dyes: alizarin dyes, azo dyes and metal phthalocyanine dyes; and trace elements such as iron salts, manganese salts, Boron salts, copper salts, cobalt salts, molybdenum salts and zinc salts.
任選地，還可包含其它附加組分，例如保護膠體、粘合劑、增稠劑、觸變劑、滲透劑、穩定劑、掩蔽劑。 Optionally, other additional components may also be included, such as protective colloids, binders, thickeners, thixotropic agents, penetrants, stabilizers, masking agents.
本發明的所述製劑可通過已知方式將所述殺真菌活性化合物組合物與常規添加劑混合而製備。所述常規添加劑如常規增充劑以及溶劑或稀釋劑、乳化劑、分散劑、和/或粘合劑或固定劑、潤濕劑、防水劑，如果需要，還可以包含催乾劑和著色劑、穩定劑、顏料、消泡劑、防腐劑、增稠劑、水以及其它加工助劑。 The formulations of the present invention can be prepared by mixing the fungicidal active compound compositions with conventional additives in a known manner. The conventional additives such as a conventional extender and a solvent or diluent, an emulsifier, a dispersant, and/or a binder or fixative, a wetting agent, a water repellent, and if necessary, a drier and a colorant may also be included. , stabilizers, pigments, defoamers, preservatives, thickeners, water and other processing aids.
殺真菌組成物不僅包括可借助合適的設備如噴霧或撒粉設備立即適用於待處理的物件，而且還包括在施用於物件之前需進行稀釋的濃縮商業組 成物。 The fungicidal composition not only includes the immediate application to the item to be treated by means of a suitable device such as a spray or dusting device, but also includes a concentrated commercial group that needs to be diluted prior to application to the article. Adult.
本發明的含吡唑醚菌酯和硫酸銅鈣殺真菌活性化合物組合物還可以與其它活性成分聯合施用，例如用於擴大活性譜或防止形成抗性。所述其它活性成分例如殺真菌劑、殺細菌劑、引誘劑、殺昆蟲劑、殺蟎劑、殺線蟲劑、生長調節劑、除草劑、安全劑、肥料或化學成分等。 The pyraclostrobin and copper copper sulfate fungicidal active compound compositions of the present invention may also be administered in combination with other active ingredients, for example, to broaden the spectrum of activity or to prevent formation of resistance. The other active ingredients are, for example, fungicides, bactericides, attractants, insecticides, acaricides, nematicides, growth regulators, herbicides, safeners, fertilizers or chemical ingredients.
作為本發明的另一方面，所述的殺真菌組成物在預防和控制作物上真菌和細菌病害的應用。 As a further aspect of the invention, the fungicidal composition is useful in the prevention and control of fungal and bacterial diseases on crops.
殺真菌活性化合物吡唑醚菌酯和硫酸銅鈣可同時施用，或分別施用，或相繼施用，分開施用時的順序對防治的結果通常無影響。 The fungicidal active compound pyraclostrobin and calcium copper sulfate can be applied simultaneously, or separately, or sequentially, and the order of separate administration usually has no effect on the results of the control.
本發明的殺真菌活性化合物組合物可以其本身施用，以其製劑形式或由其製備的使用形式施用。通過常規方式對其進行施用，例如進行澆灌、噴霧、彌霧、撒播、噴粉，以及作為處理乾燥種子的粉、幹拌粉、潮濕拌種、濕拌種、漿液拌種劑、處理種子的溶液劑、處理種子的水溶性粉劑、處理泥土的水溶性粉劑，或通過形成薄殼等。 The fungicidal active compound composition of the present invention can be administered by itself, in the form of its preparation or the form of use prepared therefrom. It is applied by conventional means, such as watering, spraying, misting, spreading, dusting, and as a dry powder for processing dry powder, dry mix, wet seed dressing, wet seed dressing, slurry dressing, and seed treatment. A solution, a water-soluble powder for treating seeds, a water-soluble powder for treating soil, or by forming a thin shell or the like.
當使用本發明的殺真菌活性化合物組合物時或本發明的殺真菌組成物時，可按照以下比例使用：處理植物部位時，活性化合物的施用率通常為0.1至10000g/ha，較佳為10至1000g/ha；處理種子時，其活性化合物的施用率為0.001至50g/kg種子，較佳為0.01至10g/kg種子；對於土壤處理：活性化合物的其施用率通常為0.1-10000g/ha，較佳1-5000g/ha。 When the fungicidal active compound composition of the present invention or the fungicidal composition of the present invention is used, it can be used in the following ratios: when the plant part is treated, the application rate of the active compound is usually from 0.1 to 10,000 g/ha, preferably 10 To 1000 g/ha; when the seed is treated, the application rate of the active compound is 0.001 to 50 g/kg seed, preferably 0.01 to 10 g/kg seed; for soil treatment: the application rate of the active compound is usually 0.1-10000 g/ha Preferably, it is from 1 to 5000 g/ha.
上述劑量僅是一般性的示例性劑量，實際施用時本領域的技術人員會根據實際情況和需要，尤其是根據待處理的植物或作物的性質以及病菌的嚴重性調整施用率。 The above dosages are merely exemplary exemplary dosages, and those skilled in the art will adjust the application rate depending on the actual conditions and needs, especially depending on the nature of the plant or crop to be treated and the severity of the pathogen.
本發明一種殺真菌活性化合物組合物，包括吡唑醚菌酯和硫酸銅鈣化合物，具有協同作用，本發明的殺真菌活性化合物組合物的殺真菌活性比單個活性化合物的活性的加和明顯更高。換言之，存在無法預測的、真實 存在的協同作用，而不僅僅是活性的增補。如上所述，當活性化合物以特定的重量比存在於本發明的殺真菌活性化合物組合物中時，協同作用特別明顯。 A fungicidal active compound composition of the invention comprising pyraclostrobin and copper copper sulfate compound having a synergistic effect, the fungicidal activity of the fungicidal active compound composition of the invention is significantly more than the sum of the activities of the individual active compounds high. In other words, there is unpredictable, real Synergies exist, not just supplements to activity. As mentioned above, the synergistic effect is particularly pronounced when the active compound is present in the fungicidal active compound composition of the invention in a specific weight ratio.
本發明的殺真菌活性化合物組合物的良好的殺真菌性能可通過以下實施例說明。雖然單獨的殺真菌活性化合物在其殺真菌作用方面活性較弱，但殺真菌活性化合物組合物顯示出超過各自作用的簡單加和的活性。 The good fungicidal properties of the fungicidal active compound compositions of the present invention are illustrated by the following examples. While the individual fungicidally active compounds are less active in their fungicidal action, the fungicidal active compound compositions exhibit a simple additive activity that exceeds their respective effects.
以下實例僅作說明之用。除另有說明外，實例中的比例均為重量百分比。 The following examples are for illustrative purposes only. The proportions in the examples are by weight unless otherwise stated.
用以下化合物製備2%吡唑醚菌酯+10%硫酸銅鈣的可濕性粉劑：
按指示的化合物比例混合殺真菌活性化合物、各種助劑及填料，然後用超細磨粉機研磨，即得到2%吡唑醚菌酯+10%硫酸銅鈣的可濕性粉劑。 The fungicidal active compound, various auxiliaries and fillers are mixed according to the indicated compound ratio, and then ground by an ultrafine mill to obtain a wettable powder of 2% pyraclostrobin + 10% copper calcium sulphate.
用以下化合物製備1%吡唑醚菌酯+50%硫酸銅鈣的可濕性粉劑：
按指示的化合物比例混合殺真菌活性化合物、各種助劑及填料，然後用超細磨粉機研磨，即得到1%吡唑醚菌酯+50%硫酸銅鈣的可濕性粉劑。 The fungicidal active compound, various auxiliaries and fillers are mixed according to the indicated compound ratio, and then ground by an ultrafine mill to obtain a wettable powder of 1% pyraclostrobin + 50% copper calcium sulphate.
用以下化合物製備1%吡唑醚菌酯+4%硫酸銅鈣的乳劑：
按指示的化合物比例製備上述成分，然後攪拌均勻得到均相。 The above ingredients were prepared in the proportions of the indicated compounds, and then uniformly stirred to obtain a homogeneous phase.
用以下化合物製備5%吡唑醚菌酯+50%硫酸銅鈣的可濕性粉劑：
按指示的化合物比例混合、粉碎及研磨，製備成可濕性粉劑。 It is mixed, pulverized and ground in the proportion of the indicated compound to prepare a wettable powder.
用以下化合物製備2%吡唑醚菌酯+50%硫酸銅鈣的水分散粒劑：
按指示的化合物比例混合吡唑醚菌酯、分散劑、潤濕劑、崩解劑和填料，經氣流粉碎機研磨後形成可濕性粉劑。然後加入硫酸銅鈣混合均勻。加水後將混合物擠壓造料。經幹法篩分後得到2%吡唑醚菌酯+50%硫酸銅鈣的水分散粒劑。 The pyraclostrobin, the dispersing agent, the wetting agent, the disintegrant, and the filler are mixed at a ratio of the indicated compound, and ground to form a wettable powder by a jet mill. Then add calcium copper sulfate and mix well. After adding water, the mixture was extruded. After dry sieving, 2% pyraclostrobin + 50% copper calcium sulphate water-dispersible granules were obtained.
用以下化合物製備0.5%吡唑醚菌酯+50%硫酸銅鈣的懸乳劑：
將吡唑醚菌酯溶解在油酸甲酯中，加入聚氧乙烯蓖麻油得到油相；按照配方將硫酸銅鈣、磺化的萘磺酸-甲醛縮合產物的鈉鹽、水經研磨和/或高速剪切後得到水相硫酸銅鈣的懸浮劑；在攪拌下將油相加入水相得到懸乳劑。 Dissolving pyraclostrobin in methyl oleate, adding polyoxyethylene castor oil to obtain an oil phase; according to the formula, calcium salt of copper sulfate, sodium salt of sulfonated naphthalenesulfonic acid-formaldehyde condensation product, water is ground and/or Or high-speed shearing to obtain a suspension of aqueous copper calcium sulphate; the oil phase is added to the aqueous phase with stirring to obtain a suspoemulsion.
用以下化合物製備10%吡唑醚菌酯+10%硫酸銅鈣的可濕性粉劑：
按指示的化合物比例混合、粉碎及研磨上述成分，製備成可濕性粉劑。 The above components were mixed, pulverized and ground in the proportion of the indicated compound to prepare a wettable powder.
用以下化合物製備40%吡唑醚菌酯+50%硫酸銅鈣的包衣顆粒劑：
在混合器中，將磨細的殺真菌活性化合物均勻塗抹到被聚乙二醇潤濕的載體上，得到無塵包衣顆粒劑。 The finely divided fungicidal active compound is evenly applied to a carrier wetted with polyethylene glycol in a mixer to obtain a dust-free coated granule.
用以下化合物製備50%吡唑醚菌酯+10%硫酸銅鈣的可濕性粉劑：
按指示的化合物比例混合、粉碎及研磨上述成分，製備成可濕性粉劑。 The above components were mixed, pulverized and ground in the proportion of the indicated compound to prepare a wettable powder.
用以下化合物製備20%吡唑醚菌酯+60%硫酸銅鈣的顆粒劑
混合並研磨活性化合物與助劑，用水潤濕，然後擠壓並在空氣流中乾燥。 The active compound and the auxiliaries are mixed and ground, wetted with water, then extruded and dried in a stream of air.
用以下化合物製備50%吡唑醚菌酯+2%硫酸銅鈣的種衣劑：
按指示的化合物比例混合上述成分，經研磨及/或高速剪切後得到種衣劑。 The above ingredients are mixed in the proportions of the indicated compounds, and ground and/or sheared at high speed to obtain a seed coating.
用以下化合物製備50%吡唑醚菌酯+5%硫酸銅鈣的微囊懸浮劑：
將PAPITM、吡唑醚菌酯及SolvessoTM200形成的油相加入含AtloxTM4913的溶液中並攪拌，形成乳狀液。加熱混合物，加入催化劑後保持2小時內溫度50℃。冷卻混合物後得到吡唑醚菌酯微囊懸浮劑。 The oil PAPI TM, pyrazole Kresoxim and Solvesso TM 200 formed with Atlox TM 4913 solution containing added and stirred to form an emulsion. The mixture was heated, and after the addition of the catalyst, the temperature was maintained at 50 ° C for 2 hours. After cooling the mixture, a pyraclostrobin microcapsule suspension was obtained.
混合AtloxTM4913、分散劑LFH、消泡劑、尿素、硫酸銅鈣和水，經高速剪切後得到懸浮劑。 Mixing Atlox TM 4913, LFH dispersants, antifoaming agents, urea, calcium sulfate and water, after high shear to give a suspension concentrate.
將得到的吡唑醚菌酯微囊懸浮劑與硫酸銅鈣的懸浮劑混合，攪拌均勻得到50%吡唑醚菌酯+5%硫酸銅鈣ZC。 The obtained pyraclostrobin microcapsule suspension agent is mixed with a copper copper sulfate suspension agent, and uniformly stirred to obtain 50% pyraclostrobin + 5% copper calcium sulfate ZC.
用以下化合物製備50%吡唑醚菌酯+1%硫酸銅鈣的懸乳劑：
將吡唑醚菌酯溶解在SolvessoTM200中，然後加入聚氧乙烯蓖麻油，得到吡唑醚菌酯的油相。 Kresoxim pyrazole was dissolved in Solvesso TM 200, followed by addition of a polyoxyethylene castor oil, to give an oil phase of Kresoxim-pyrazol.
將脂肪醇聚氧乙烯醚磺基琥珀酸單酯二鈉、改性木質素磺酸鈣、硫酸銅鈣和水按比例混合，經研磨和高速剪切後得到硫酸銅鈣的懸浮劑。 The fatty alcohol polyoxyethylene ether sulfosuccinate monosodium disodium, the modified calcium lignosulfonate, the copper calcium sulfate and the water are mixed in proportion, and after grinding and high-speed shearing, a suspension of copper copper sulfate is obtained.
將含吡唑醚菌酯的油相加入到含硫酸銅鈣的懸浮劑中並攪拌，得到懸乳劑。 The oil phase containing pyraclostrobin is added to a suspension containing calcium copper sulfate and stirred to obtain a suspoemulsion.
用以下化合物製備50%吡唑醚菌酯+0.5%硫酸銅鈣的乳劑：
混合及攪拌上述成分直至形成透明均相。 The above ingredients are mixed and stirred until a transparent homogeneous phase is formed.
用以下化合物製備20%吡唑醚菌酯+30%硫酸銅鈣的水分散粒劑：
均勻混合吡唑醚菌酯、硫酸銅鈣、分散劑、潤濕劑、崩解劑和填料，經過氣流粉碎成可濕性粉劑；再加入一定量的水混合擠壓造料。經乾燥篩分後得到20%吡唑醚菌酯+30%硫酸銅鈣的水分散粒劑。 The pyraclostrobin, calcium copper sulfate, dispersant, wetting agent, disintegrant and filler are uniformly mixed, and pulverized into a wettable powder by air flow; and a certain amount of water is added to mix and extrude the material. After drying and sieving, a water-dispersible granule of 20% pyraclostrobin + 30% copper calcium sulfate was obtained.
用以下化合物製備5%吡唑醚菌酯+30%硫酸銅鈣可濕性粉劑：
混合、研磨及粉碎上述成分製備成可濕性粉劑。 The above ingredients are mixed, ground and pulverized to prepare a wettable powder.
用以下化合物製備10%吡唑醚菌酯+90%硫酸銅鈣的混合物：
吡唑醚菌酯和硫酸銅鈣按照上述比例混合均勻。 Pyraclostrobin and copper copper sulfate are uniformly mixed in the above ratio.
用以下化合物製備20%吡唑醚菌酯+80%硫酸銅鈣的混合物：
吡唑醚菌酯和硫酸銅鈣按照上述比例混合均勻。 Pyraclostrobin and copper copper sulfate are uniformly mixed in the above ratio.
依孫雲沛法(Sun Yunpei’u method)計算出各藥劑的毒性指數及混劑的共毒係數(CTC值)，當CTC80，則組成物表現出拮抗作用，當80<CTC<120，則組成物表現出相加作用(additive effect)，當CTC120，則組成物表現出協同作用。 According to the Sun Yunpei'u method, the toxicity index of each agent and the co-toxicity coefficient (CTC value) of the mixture were calculated as CTC. 80, the composition exhibits an antagonistic effect. When 80<CTC<120, the composition exhibits an additive effect when CTC 120, the composition exhibits a synergistic effect.
實測毒性指數(ATI)=(標準藥劑EC50/供試藥劑EC50)*100 Measured toxicity index (ATI) = (standard drug EC50 / test drug EC50) * 100
理論毒性指數(TTI)=(A藥劑毒性指數*混劑中A的百分含量)+(B藥劑毒性指數*混劑中B的百分含量) Theoretical Toxicity Index (TTI) = (A Pharmacy Toxicity Index * Percentage of A in the mixture) + (B Pharmacy Toxicity Index * Percentage of B in the mixture)
共毒係數(CTC)=[混劑實測毒性指數(ATI)/混劑理論毒性指數(TTI)]*100 Co-toxicity coefficient (CTC) = [mixed measured toxicity index (ATI) / mixed theoretical toxicity index (TTI)] * 100
選自長勢一致的黃瓜苗，用potter噴霧塔在50PSI壓力噴霧，每盆大約5mL，每個藥劑設置12個濃度梯度。藥劑處理後24小時接菌，將采自田間的黃瓜霜黴病葉在黃瓜苗上方均勻抖落分生孢子進行接種，然後將黃瓜苗放入溫室中培養。 Selected from a consistent cucumber seedling, sprayed with a potter spray tower at 50 PSI pressure, approximately 5 mL per pot, with 12 concentration gradients per agent. The bacteria were inoculated 24 hours after the treatment, and the cucumber downy mildew leaves collected from the field were uniformly shaken off the cucumber seedlings to inoculate the conidia, and then the cucumber seedlings were placed in a greenhouse for cultivation.
七天後按照黃瓜霜黴病的發病分級標準全株調查病情指數，並計算預防和控制效果，然後用最小二乘法計算抑制中濃度EC50，再依孫雲沛法計算共毒係數(CTC)。實驗結果載列於下表一中。 After seven days the incidence of cucumber downy mildew rating according to standard survey the whole plant disease indices, and calculates the effect of the prevention and control, and then the concentration of EC 50, and then calculated according to the method of Sun Yunpei toxicity coefficient (CTC) inhibition is calculated by the least squares method. The experimental results are listed in Table 1 below.
從表一可知，吡唑醚菌酯和硫酸銅鈣在預防和控制黃瓜霜黴病的比例在1：100~100：1的範圍裡時，共毒係數均大於120，說明兩者在這個範圍內的混配均表現為協同作用，尤其是當兩者的比例在1：5內時，協同作用尤為突出。 It can be seen from Table 1 that when the ratio of pyraclostrobin and calcium copper sulfate in the prevention and control of cucumber downy mildew is in the range of 1:100~100:1, the co-toxicity coefficient is greater than 120, indicating that the two are in this range. The mixing within the performance is synergistic, especially when the ratio of the two is within 1:5, the synergy is particularly prominent.
採用果園香蕉黑星病病菌自然接種法。選擇剛斷蕾果穗，果面光滑，均不見黑星病斑。將供試藥劑和對照藥劑按照一定的濃度製成藥液，分佈均勻噴灑在蕉果上，每處理四次重複。 Adopt natural inoculation method of orchard banana black spot disease. Choosing just broken buds, the fruit surface is smooth, and no black spot lesions are seen. The test agent and the control agent were prepared into a drug solution according to a certain concentration, and the distribution was evenly sprayed on the banana fruit, and the treatment was repeated four times.
處理25天後調查蕉果發病情況。按照香蕉蕉果的發病分級標準調查病情指數，並計算預防和控制效果，然後用最小二乘法計算抑制中濃度EC50，再依孫雲沛法計算共毒係數(CTC)。實驗結果載列於下表二中。 The incidence of banana fruit was investigated after 25 days of treatment. According banana banana fruit grading incidence of disease index survey, and calculates the effect of the prevention and control, and then the concentration of EC 50, and then calculated according to the method of Sun Yunpei toxicity coefficient (CTC) inhibition is calculated by the least squares method. The experimental results are shown in Table 2 below.
從表二可知，吡唑醚菌酯和硫酸銅鈣預防和控制香蕉黑星病在比例1：100~100：1的範圍時，共毒係數均大於120，說明兩者在這個範圍內的混配均表現為協同作用，尤其是當兩者的比例在1：5內時，協同作用尤為突出。 It can be seen from Table 2 that pyraclostrobin and copper calcium sulfate prevent and control banana scab in the range of 1:100~100:1, the co-toxicity coefficient is greater than 120, indicating that the two are mixed in this range. The coordination is characterized by synergy, especially when the ratio of the two is within 1:5, the synergy is particularly prominent.
選自長勢一致的馬鈴薯葉苗，每個處理選用3盆供試葉苗，用potter噴 霧塔在50PSI壓力噴霧，每盆大約5mL，每個藥劑設置12個濃度梯度。藥劑處理後24小時接菌，將采自田間的馬鈴薯早疫病葉在馬鈴薯苗上方均勻抖落分生孢子進行接種，然後將馬鈴薯葉苗放入溫室中培養。 Choose from the potato shoots with the same growth, use 3 pots for each treatment, spray with potter The fog tower is sprayed at 50 PSI pressure, approximately 5 mL per pot, with 12 concentration gradients per medicament. The bacteria were inoculated 24 hours after the treatment, and the potato early blight leaves collected from the field were evenly shaken off the potato seedlings to inoculate the conidia, and then the potato leaf seedlings were placed in a greenhouse for cultivation.
七天後按照馬鈴薯早疫病的發病分級標準全株調查病情指數，並計算預防和控制效果，然後用最小二乘法計算抑制中濃度EC50，再依孫雲沛法計算共毒係數(CTC)。實驗結果載列於下表三中。 After seven days the incidence according potato early blight disease index grading survey the whole plant, and calculates the effect of the prevention and control, and a concentration EC 50 inhibition is calculated by the least squares method, the co-toxicity coefficient is calculated again (CTC) by Sun Yunpei method. The experimental results are listed in Table 3 below.
從表三可知，吡唑醚菌酯和硫酸銅鈣預防和控制馬鈴薯早疫病在比例 1：100~100：1的範圍時，共毒係數均大於120，說明兩者在這個範圍內的混配均表現為協同作用，尤其是當兩者的比例在5：1內時，協同作用尤為突出。 As can be seen from Table 3, pyraclostrobin and copper calcium sulfate prevent and control the proportion of potato early blight In the range of 1:100~100:1, the co-toxicity coefficient is greater than 120, indicating that the mixing of the two in this range is synergistic, especially when the ratio of the two is within 5:1. Especially outstanding.
當活性化合物組成物的作用超過當各活性化合物單獨施用時的作用的總和時，存在協同作用。兩種活性化合物的特定組合物的預期作用可使用所謂的"Colby公式"(參見S.R.Colby,"Calculating Synergistic and Antagonistic Responses of Herbicide Combinations“,Weeds 1967,15,20-22)如下計算：如果X是當使用用量為m g/ha或濃度為m ppm的活性化合物A時的活性；Y是當使用用量為n g/ha或濃度為n ppm的活性化合物B時的活性，表示為占未處理對照的百分率；E是當使用用量為m和n g/ha或濃度為m和n ppm的活性化合物A和B時的活性，則
如果實際觀察的活性(O)大於預期活性(E)，那麼該組成物具有超加和性，即具有協同作用。 If the actually observed activity (O) is greater than the expected activity (E), then the composition is superadditive, i.e., has a synergistic effect.
以下生物測試例用以說明本發明。但是，本發明並不限於這些實施例。 The following biological test examples are used to illustrate the invention. However, the invention is not limited to the embodiments.
向盆栽的黃瓜植株的葉子噴灑表四所示活性化合物濃度的懸浮劑。 The suspension of the active compound concentration shown in Table 4 was sprayed onto the leaves of the potted cucumber plants.
第二天將處理的植物接種黃瓜霜黴病的孢子懸浮液。然後將盆放在 20-22℃下的具有高大氣濕度(90-95%)的室中24小時。在此期間，孢子發芽並且芽管滲入葉組織中。第二天，將測試植物返回至溫室中並在20-22℃和65-70%相對大氣濕度下培育另外7天。然後目測葉子上霜黴病發展的程度。實驗結果載列於下表四中。 The treated plants were inoculated with a spore suspension of cucumber downy mildew the next day. Then put the pot 24 hours in a chamber with high atmospheric humidity (90-95%) at 20-22 °C. During this time, the spores germinate and the germ tubes infiltrate into the leaf tissue. The next day, the test plants were returned to the greenhouse and incubated for an additional 7 days at 20-22 ° C and 65-70% relative atmospheric humidity. The extent of development of downy mildew on the leaves was then visually observed. The experimental results are shown in Table 4 below.
向盆栽的馬鈴薯植株的葉子噴灑表五所示活性化合物濃度的懸浮劑。 Suspending agents of the active compound concentrations shown in Table 5 were sprayed onto the leaves of potted potato plants.
第二天將處理的植物接種馬鈴薯早疫病的孢子懸浮液。然後將盆放在20-22℃下的具有高大氣濕度(90-95%)的室中24小時。在此期間，孢子發芽並且芽管滲入葉組織中。第二天，將測試植物返回至溫室中並在20-22℃和65-70%相對大氣濕度下培育另外7天。然後目測葉子上早疫病發展的程度。實驗結果載列於下表五中。 The treated plants were inoculated with spore suspensions of potato early blight the next day. The pots were then placed in a chamber at 20-22 ° C with high atmospheric humidity (90-95%) for 24 hours. During this time, the spores germinate and the germ tubes infiltrate into the leaf tissue. The next day, the test plants were returned to the greenhouse and incubated for an additional 7 days at 20-22 ° C and 65-70% relative atmospheric humidity. Then visually measure the extent of early blight development on the leaves. The experimental results are listed in Table 5 below.
以下測試中，在作物發病初期開始噴藥。重複處理四次。將株盆隨機分組，以三株香蕉樹為一個小組。施藥時間為九月至十月。噴水量約為100kg/667m2，果樹全株噴施，均勻噴施果面及葉面葉背，直至滴水為止。目測香蕉黑星病發展的程度。實驗結果載列於下表六中。 In the following tests, spraying was started at the beginning of the crop. Repeat the process four times. The pots were randomly grouped into three groups of banana trees. The application time is from September to October. The amount of water spray is about 100kg/667m 2 , and the whole plant is sprayed, and the fruit surface and the leaf back are evenly sprayed until dripping. Visually measure the extent of banana scab development. The experimental results are listed in Table 6 below.
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| US20090143416A1 (en) * | 2006-03-14 | 2009-06-04 | Harald Kohle | Method of Inducing Tolerance of Plants Against Bacterioses |
| WO2009071389A1 (en) * | 2007-12-05 | 2009-06-11 | Basf Se | Fungicide mixtures |
| GB0800761D0 (en) * | 2008-01-16 | 2008-02-27 | Syngenta Participations Ag | Fungicidal compositions |
| KR20120107068A (en) * | 2009-07-28 | 2012-09-28 | 바스프 에스이 | A method for increasing the level of free amino acids in storage tissues of perennial plants |
| KR20120106941A (en) * | 2009-09-25 | 2012-09-27 | 바스프 에스이 | Method for reducing pistillate flower abortion in plants |
| CN102258057B (en) * | 2011-05-25 | 2013-07-24 | 江苏龙灯化学有限公司 | Sterilizing agent composition with synergizing action |
| CN102334512B (en) * | 2011-07-12 | 2013-12-04 | 江苏龙灯化学有限公司 | Pesticide composition containing fenoxanil and copper calcium sulphate and use thereof |
| CN102217621A (en) * | 2011-07-18 | 2011-10-19 | 青岛瀚生生物科技股份有限公司 | Bactericide composition containing pyraclostrobin and copper rosinate |
| CN102422843B (en) * | 2011-11-18 | 2013-07-31 | 江苏龙灯化学有限公司 | Agricultural or gardening fungicide composition and method for controlling plant diseases |
| CN102726379B (en) * | 2012-06-09 | 2015-11-18 | 广东中迅农科股份有限公司 | Pyraclostrobin water dispersible granule and preparation method thereof |
| CN102669181B (en) * | 2012-06-13 | 2014-12-10 | 江苏龙灯化学有限公司 | Sterilization composition containing captan and copper calcium sulfate and application of sterilization composition |
| CN103329937B (en) * | 2013-07-03 | 2015-07-15 | 江苏龙灯化学有限公司 | Composition of bactericidal active components |
| CN103348995A (en) * | 2013-07-30 | 2013-10-16 | 江苏龙灯化学有限公司 | Bactericidal active ingredient composition |
-
2013
- 2013-11-04 GB GB1319424.6A patent/GB2519982B/en active Active
-
2014
- 2014-08-28 WO PCT/CN2014/085369 patent/WO2015062353A1/en active Application Filing
- 2014-08-28 CN CN201410431387.6A patent/CN104604938A/en active Pending
- 2014-10-31 TW TW103137724A patent/TWI617244B/en not_active IP Right Cessation
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2016
- 2016-04-28 PH PH12016500798A patent/PH12016500798A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PH12016500798B1 (en) | 2016-06-13 |
| CN104604938A (en) | 2015-05-13 |
| GB2519982B (en) | 2016-04-27 |
| WO2015062353A1 (en) | 2015-05-07 |
| PH12016500798A1 (en) | 2016-06-13 |
| GB201319424D0 (en) | 2013-12-18 |
| TWI617244B (en) | 2018-03-11 |
| GB2519982A (en) | 2015-05-13 |
| WO2015062353A9 (en) | 2016-03-10 |
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