TW201513799A - Fat-soluble-substance-containing powder composition and method for manufacturing same - Google Patents

Fat-soluble-substance-containing powder composition and method for manufacturing same Download PDF

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TW201513799A
TW201513799A TW102144813A TW102144813A TW201513799A TW 201513799 A TW201513799 A TW 201513799A TW 102144813 A TW102144813 A TW 102144813A TW 102144813 A TW102144813 A TW 102144813A TW 201513799 A TW201513799 A TW 201513799A
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fat
soluble substance
powder composition
water
substance
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Satoshi Watanabe
Tatsuya Ogawa
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Yokohama Oils & Fats Industry Co Ltd
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/52—Adding ingredients
    • A23L2/68—Acidifying substances
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/02—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation containing fruit or vegetable juices
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/52—Adding ingredients
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/30—Artificial sweetening agents
    • A23L27/33—Artificial sweetening agents containing sugars or derivatives
    • A23L27/34—Sugar alcohols
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/10—Foods or foodstuffs containing additives; Preparation or treatment thereof containing emulsifiers
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P10/00—Shaping or working of foodstuffs characterised by the products
    • A23P10/40—Shaping or working of foodstuffs characterised by the products free-flowing powder or instant powder, i.e. powder which is reconstituted rapidly when liquid is added
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P10/00—Shaping or working of foodstuffs characterised by the products
    • A23P10/40—Shaping or working of foodstuffs characterised by the products free-flowing powder or instant powder, i.e. powder which is reconstituted rapidly when liquid is added
    • A23P10/47—Shaping or working of foodstuffs characterised by the products free-flowing powder or instant powder, i.e. powder which is reconstituted rapidly when liquid is added using additives, e.g. emulsifiers, wetting agents or dust-binding agents

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  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Nutrition Science (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mycology (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Medicinal Preparation (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Edible Oils And Fats (AREA)

Abstract

To provide a fat-soluble-substance-containing powder composition that is dispersed in a transparent manner without scattering light when dispersed in water, an acidic aqueous solution, or an aqueous solution having a high ionic strength. The present invention contains (a) a fat-soluble substance, (b) a sucrose fatty acid ester having an HLB value of 11 or above, (c) an ionic amphiphilic substance, and (d) a sugar or a sugar alcohol, the dispersed particles containing the fat-soluble substance when dissolved in water having an average particle diameter, as measured by dynamic light scattering, of 10-150 nm.

Description

含脂溶性物質之粉末組成物及其製造方法 Powder composition containing fat-soluble substance and preparation method thereof

本發明係與含脂溶性物質之粉末組成物及其製造方法相關，具體係與：當分散於水中時，脂溶性物質保持安定之分散狀態而不發生沉澱或者浮游，即使於酸性水溶液以及高離子強度水溶液中亦不致發生光散射或發生渾濁之含脂溶性物質之粉末組成物及其製造方法相關。 The present invention relates to a powder composition containing a fat-soluble substance and a method for producing the same, in particular, when dispersed in water, the fat-soluble substance remains in a stable dispersion state without precipitation or floating, even in an acidic aqueous solution and high ions. A powder composition containing a fat-soluble substance which does not cause light scattering or turbidity in a strong aqueous solution, and a method for producing the same.

當將脂溶性物質包含於食物中時，尤其是為了將脂溶性物質分散於飲料等之水中，廣泛採用藉由添加親水性乳化劑並充分攪拌以使脂溶性物質乳化之方法。 When a fat-soluble substance is contained in a food, in particular, in order to disperse a fat-soluble substance in water of a drink, etc., the method of emulsifying a fat-soluble substance by adding a hydrophilic emulsifier and stirring well is widely used.

脂溶性物質之攪拌係採用螺旋漿翼及渦輪翼等利用攪拌翼進行攪拌、或者利用均質機或高剪力攪拌機進行攪拌。尤其是均質機及高剪力攪拌機由於其具有強大之剪力，是故廣泛應用於乳化及分散之用途。 The stirring of the fat-soluble substance is carried out by stirring with a stirring blade such as a propeller blade or a turbine blade, or by a homogenizer or a high shear mixer. In particular, homogenizers and high shear mixers are widely used in emulsification and dispersion because of their strong shearing force.

尤其是為了使脂溶性物質長時間安定地分散於水中且使分散後之液體具有高透明度，是故使用高親水性之乳化劑或者利用高壓均質機(highpressurehomogenizer)、微射流均質機(Microfluidizer) 等進行微細化處理。 In particular, in order to allow the fat-soluble substance to be stably dispersed in water for a long period of time and to impart high transparency to the liquid after dispersion, it is possible to use a highly hydrophilic emulsifier or a high pressure homogenizer or a microfluidizer. Wait for the miniaturization process.

採用高親水性之乳化劑可减小脂溶性物質之水/脂溶性物質之間之界面張力，抑制脂溶性物質之微細化所導致之界面能量之增加使其維持低水準，並且可進一步减小分散於水中之脂溶性物質之粒徑。 The use of a highly hydrophilic emulsifier reduces the interfacial tension between the water-soluble fat-soluble substance of the fat-soluble substance, suppresses the increase of the interface energy caused by the miniaturization of the fat-soluble substance, maintains the low level, and can be further reduced. The particle size of the fat-soluble substance dispersed in water.

另外，藉由使用高壓均質機，水及脂溶性物質通過流路時將產生大於均質機及高剪力攪拌機等之剪力，是故可使脂溶性物質之粒徑進一步微細化。 Further, by using a high-pressure homogenizer, when the water and the fat-soluble substance pass through the flow path, a shear force larger than that of the homogenizer and the high shear mixer is generated, so that the particle diameter of the fat-soluble substance can be further refined.

微射流均質機具備與高壓均質機相同之機構，二液於流路之下遊於高壓下衝突而產生衝擊力、以及其後高壓力被釋放時產生之膨脹效果及空泡效應，藉以實現微細化。 The micro-jet homogenizer has the same mechanism as the high-pressure homogenizer, and the two liquids collide with each other under the high pressure in the downstream of the flow path to generate an impact force, and the expansion effect and the cavitation effect generated when the high pressure is released thereafter, thereby realizing the fineness. Chemical.

如上所述，實現微細化之脂溶性物質分散液，由於其分散之粒子小故粒子所受之浮力及重力亦小，進而可抑制沉澱及粒子上升至液表面。另外，由於粒子小，周圍之溶劑分子之熱運動將會導致粒子強力反彈而產生劇烈之布朗運動，是故能够保持分散狀態。 As described above, the finely-dissolved fat-soluble substance dispersion liquid has a small buoyancy and a small amount of gravity due to the small particles dispersed therein, and further suppresses precipitation and particles from rising to the liquid surface. In addition, because the particles are small, the thermal motion of the surrounding solvent molecules will cause the particles to rebound strongly and produce intense Brownian motion, so that they can remain dispersed.

另外，如果微細化粒子當小於可視光波長400~800nm則會發生雷利散射。因雷利散射之強度與粒徑之6次方成正比，是故微細化程度越高，散射強度則越低。如果粒子約100nm以下，則粒子濃度所導致之散射减少，此時分散液呈透明液體。 In addition, Rayleigh scattering occurs when the fine particles are smaller than the visible light wavelength of 400 to 800 nm. Since the intensity of the Rayleigh scattering is proportional to the sixth power of the particle diameter, the higher the degree of refinement, the lower the scattering intensity. If the particles are about 100 nm or less, the scattering due to the particle concentration is reduced, and at this time, the dispersion is a transparent liquid.

將如上調製之脂溶性物質分散水中所得到之液體可以稀釋於食物中從而以將脂溶性物質摻合於食物 中；而當將該脂溶性物質摻合到不含水之粉末飲料，或者當該脂溶性物質形成為容易分散於水中之粉末狀脂溶性物質等用途時，則需要將該分散有脂溶性物質之液體進行乾燥以製成粉末。然而，分散之脂溶性物質粒子於乾燥步驟中變得不安定，將會發生合併或者凝聚，因此乾燥後之粉末重新分散於水中時將難以取得與乾燥前之液體同等程度之透明感。 The liquid obtained by dispersing the fat-soluble substance prepared above in water can be diluted in food to blend the fat-soluble substance into the food. When the fat-soluble substance is blended into a non-aqueous powdered beverage, or when the fat-soluble substance is formed into a powdery fat-soluble substance which is easily dispersed in water, it is necessary to disperse the fat-soluble substance. The liquid is dried to make a powder. However, the dispersed fat-soluble substance particles become unstable during the drying step, and may merge or aggregate. Therefore, when the dried powder is redispersed in water, it is difficult to obtain the same degree of transparency as the liquid before drying.

於乾燥步驟中，由於粒子之間之間隔減小、 分散媒體亦即水量减少、乾燥時所受之熱等因素之影響而無法維持分散狀態，導致發生合併或凝聚。 In the drying step, due to the decrease in the spacing between the particles, The dispersing medium, that is, the influence of factors such as a decrease in water quantity and heat upon drying, cannot maintain the dispersion state, resulting in merger or agglomeration.

當如上述所取得之含脂溶性物質之粉末組成 物溶解於水中時，以及其溶解於酸性或高離子強度之水溶液中時，將進一步發生凝聚及沉澱。溶解於水中後將其變成為酸性液體或變成為高離子強度之液體時亦同樣會發生凝聚及沉澱。在此酸性係指pH值2~6之間，高離子強度係指離子強度0.05M以上。 Powder composition of a fat-soluble substance obtained as described above When the substance is dissolved in water, and when it is dissolved in an acidic or high ionic strength aqueous solution, aggregation and precipitation will further occur. Coagulation and precipitation also occur when dissolved in water and then turned into an acidic liquid or a liquid having a high ionic strength. In this case, the acidity means a pH between 2 and 6, and the high ionic strength means an ionic strength of 0.05 M or more.

因此，對於脂溶性物質用於粉末飲料、或者 其用作容易分散於水中之粉末狀脂溶性物質之用途，難以將脂溶性物質配制成呈透明狀溶解於水中，從而限制了脂溶性物質用於粉末飲料等用途。 Therefore, for fat-soluble substances for powdered drinks, or It is used as a powdery fat-soluble substance which is easily dispersed in water, and it is difficult to prepare a fat-soluble substance to be dissolved in water in a transparent form, thereby limiting the use of a fat-soluble substance for powdered drinks and the like.

於是，強烈地期盼出現一種當將脂溶性物質 摻合於粉末飲料中時，能夠透明地溶解於水中之脂溶性物質之粉末組成物。 Therefore, there is a strong expectation of a fat-soluble substance. When blended in a powdered beverage, it can be transparently dissolved in a powder composition of a fat-soluble substance in water.

下面例舉與本發明相關技術領域之代表性背 景技術。 The following is a representative example of the technical field related to the present invention. Scene technology.

專利文獻1係公開了一種透明乳化物，其係將脂溶性物質之輔酶Q10溶解於油脂類後，添加精製聚甘油脂肪酸酯、含水率50%以下之多元醇之混合溶液進行乳化，而得到對於酸性飲料、醇飲料等表現良好之乳化安安定性之透明乳化物。然而其缺點為，若將乳化物添加至粉末飲料、粉末湯料等中，粉末會被乳化液濕潤而無法維持粉末狀。 Patent Document 1 discloses a transparent emulsion obtained by dissolving coenzyme Q10 of a fat-soluble substance in oils and fats, and then emulsification by adding a mixed solution of a purified polyglycerin fatty acid ester and a polyol having a water content of 50% or less. A transparent emulsion of emulsified stability that is good for acidic beverages, alcoholic beverages, etc. However, the disadvantage is that if the emulsion is added to a powdered beverage, a powdered soup or the like, the powder is wetted by the emulsion and cannot be maintained in a powder form.

專利文獻2係公開了一種含輔酶Q10之粉末 組成物，其係將脂溶性物質之輔酶Q10添加至含有辛烯基丁二酸鈉澱粉、糊精、甘油水溶液中，於60℃下將輔酶Q10乳化後，再藉由高壓均質機均質化後進行噴霧乾燥而得。此時所得之粉末組成物雖可添加至粉末飲料、粉末湯料等中，然而如果該粉末組成物溶解於水中，則由於輔酶Q10之粒徑係0.3μm左右而會發生光散射並渾濁，從而會有溶解於水中時有損外觀之缺點。 Patent Document 2 discloses a powder containing coenzyme Q10 The composition is obtained by adding coenzyme Q10 of a fat-soluble substance to an aqueous solution containing sodium octenylsuccinate, dextrin, and glycerin, emulsification of coenzyme Q10 at 60 ° C, and homogenization by a high-pressure homogenizer. It is obtained by spray drying. The powder composition obtained at this time may be added to a powdered beverage, a powdered soup or the like. However, if the powder composition is dissolved in water, light scattering and turbidity occur due to the particle size of the coenzyme Q10 being about 0.3 μm. There is a disadvantage of being detrimental to the appearance when dissolved in water.

專利文獻3公開了一種含可食性油性材料之 粉末素材其係將可食性油性材料於含聚甘油脂肪酸酯以及/或者脂肪酸蔗糖酯、賦形劑之水溶液中進行混合並將其進行乾燥，而得以透明地溶解於水中之含可食性油性材料之粉末素材。此時所取得之粉末素材之缺點在於，該粉末素材會因可食性油性材料，而無法成為透明地溶解之粉末素材。並且也有當脂肪酸蔗糖酯之單酯體之含量小於95%時，會發生因以雜質存在的二酯體、三酯體所導致的渾濁，而無法透明地溶解之缺點。聚甘油脂肪酸酯脂肪酸之 碳數為12以下，因此其添加到飲食品中食用時具有呈味甚苦之缺點。其還有一個缺點是，當將其添加到粉末飲料、粉末湯料等、已是酸性或高離子強度之水溶液中，或者添加到會成酸性或高離子強度之水溶液中時，將發生凝聚或者合併導致渾濁從而無法取得透明感。另外，會有因賦形劑以及乳化劑的種類而無法透明溶解之缺點。 Patent Document 3 discloses an edible oil-containing material The powder material is an edible oily material which is prepared by mixing an edible oily material in an aqueous solution containing a polyglycerin fatty acid ester and/or a fatty acid sucrose ester and an excipient, and drying it to be transparently dissolved in water. Powder material. The disadvantage of the powder material obtained at this time is that the powder material cannot be a transparently dissolved powder material due to the edible oily material. Further, when the content of the monoester body of the sucrose fatty acid ester is less than 95%, turbidity due to the diester body or the triester body in the presence of impurities may occur, and the film may not be transparently dissolved. Polyglycerol fatty acid ester fatty acid Since the carbon number is 12 or less, it has a disadvantage of being bitter when added to foods and drinks. A further disadvantage is that when it is added to a powdered beverage, a powder soup or the like, an aqueous solution which is already acidic or high in ionic strength, or added to an aqueous solution which is acidic or highly ionic strength, aggregation will occur or The merger resulted in turbidity and a lack of transparency. Further, there is a disadvantage that the type of the excipient and the emulsifier cannot be transparently dissolved.

專利文獻4公開了一種取得將脂溶性物質之 具有類異戊二烯結構以及/或者醌結構之化合物包攝至γ-環糊精中以使溶解度提昇之粉末之方法。然而，能够包攝至γ-環糊精之脂溶性物質受限於其分子之大小或結構，有通用性欠缺之缺點。另外，即使粉末溶解於水，但卻因被包攝物而不能溶解於水中，或者即使溶解了亦僅限於低濃度之情形下，會有無法維持於較高濃度下的透明狀態之缺點。 Patent Document 4 discloses obtaining a fat-soluble substance A method of coating a compound having an isoprenoid structure and/or a ruthenium structure into a γ-cyclodextrin to increase the solubility. However, the fat-soluble substance capable of encapsulating to γ-cyclodextrin is limited by the size or structure of its molecule, and has the disadvantage of lack of versatility. Further, even if the powder is dissolved in water, it cannot be dissolved in water due to the inclusion of the object, or if it is dissolved to a low concentration, there is a disadvantage that it cannot be maintained in a transparent state at a relatively high concentration.

如上所述，迄今為止尚不存在能够添加到食 物中、尤其是能够添加到以飲料、粉末飲料，粉末湯料為中心之水系食品中時能够透明地溶解之足以令人滿意之含脂溶性物質之粉末組成物。 As mentioned above, there is no such thing as being able to add to the food so far. A powder composition containing a fat-soluble substance which is capable of being transparently dissolved when it is added to an aqueous food centered on a beverage, a powdered beverage, or a powdered soup.

先前技術相關文獻 Prior art related literature 〔專利文獻〕 [Patent Document]

專利文獻1：日本特開2009-207383號公報 Patent Document 1: Japanese Laid-Open Patent Publication No. 2009-207383

專利文獻2：日本專利4842824號公報 Patent Document 2: Japanese Patent No. 4842824

專利文獻3：日本特開2003-055688號公報 Patent Document 3: Japanese Laid-Open Patent Publication No. 2003-055688

專利文獻4：日本特開2006-249050號公報 Patent Document 4: Japanese Laid-Open Patent Publication No. 2006-249050

本發明欲解決之課題係在於，使如上所述之脂溶性物質形成為於溶解於水中時能夠透明狀分散、並且於酸性水溶液及高離子強度水溶液中亦能够維持透明狀態之粉末油脂組成物，以便脂溶性物質能够摻合到於溶解於水中時具有高透明感之食物、特別是粉末飲料、粉末湯料中。 The problem to be solved by the present invention is to form a fat-soluble substance as described above, which is capable of being transparently dispersed when dissolved in water, and capable of maintaining a transparent state in an acidic aqueous solution and a high ionic strength aqueous solution. Therefore, the fat-soluble substance can be blended into a food having a high transparency when dissolved in water, particularly a powdered beverage or a powdered soup.

為解決上述課題，經本發明人等銳意研究，成功地找到將脂溶性物質分散於水時可用作乳化劑、以及可用於噴霧乾燥時之賦形劑及添加劑，當將於水溶液中微細化到於可視光下不會發生散射光之脂溶性物質之分散粒子進行噴霧乾燥而形成粉末時不會發生凝聚及合併，進而將該粉末溶解於水、酸性水溶液以及高離子強度水溶液中時更能够使脂溶性物質之粒子重新複元並分散。 In order to solve the above problems, the inventors of the present invention have earnestly studied to find an excipient and an additive which can be used as an emulsifier when dispersing a fat-soluble substance in water, and which can be used for spray drying, and are refined in an aqueous solution. When the dispersed particles of the fat-soluble substance which does not scatter light under visible light are spray-dried to form a powder, aggregation and merging do not occur, and further, when the powder is dissolved in water, an acidic aqueous solution, and a high ionic strength aqueous solution, the powder can be further dissolved. The particles of the fat-soluble substance are recovered and dispersed.

亦即，本發明之第1發明係：一種含脂溶性物質之粉末組成物，其特徵係含(a)脂溶性物質、(b)HLB值為11以上之脂肪酸蔗糖酯、(c)離子性之兩親媒性物質、 (d)糖類或者糖醇，且前述脂溶性物質之分散粒子溶解於水時，以動態光散射法所測定之平均粒徑係10nm以上且150nm以下。 That is, the first invention of the present invention is a powder composition containing a fat-soluble substance, characterized by (a) a fat-soluble substance, (b) a fatty acid sucrose ester having an HLB value of 11 or more, and (c) ionicity. Two steroidal substances, (d) A saccharide or a sugar alcohol, and when the dispersed particles of the fat-soluble substance are dissolved in water, the average particle diameter measured by a dynamic light scattering method is 10 nm or more and 150 nm or less.

本發明之第2發明係：一種含脂溶性物質之粉末组成物之製造方法，其係製造一種含脂溶性物質之分散粒子溶解於水時，以動態光散射法所測定之平均粒徑係10nm以上且150nm以下，其特徵係包括下述(1)~(4)之步驟，且，步驟(1)~(3)之任一步驟係包括添加、混合離子性之兩親媒性物質之過程，且步驟(1)~(3)之任一步驟係包括添加、混合糖類或者糖醇之過程；(1)於水系溶劑中混合HLB值11以上之脂肪酸蔗糖酯以取得水相部份之步驟、(2)融化脂溶性物質以取得油相部份之步驟、(3)將前述油相部份混合至前述水相部份中，於80℃以上之環境下進行乳化以取得預備乳化液之步驟、(4)將前述預備乳化液進行噴霧乾燥以取得前述含脂溶性物質之粉末組成物之步驟。 According to a second aspect of the invention, there is provided a method for producing a powder composition containing a fat-soluble substance, wherein when a dispersed particle containing a fat-soluble substance is dissolved in water, an average particle diameter of 10 nm measured by a dynamic light scattering method is obtained. The above and 150 nm or less are characterized by the following steps (1) to (4), and any of the steps (1) to (3) includes the process of adding and mixing the ionic two affinities. And any one of steps (1) to (3) includes a process of adding or mixing a sugar or a sugar alcohol; (1) a step of mixing a fatty acid sucrose ester having an HLB value of 11 or more in an aqueous solvent to obtain an aqueous phase portion (2) a step of melting the fat-soluble substance to obtain the oil phase portion, (3) mixing the oil phase portion into the aqueous phase portion, and emulsification in an environment of 80 ° C or higher to obtain a preliminary emulsion. Step (4) A step of spray-drying the preliminary emulsion to obtain the powder composition of the fat-soluble substance.

本發明之第3發明係一種飲食物，其特徵係摻合有如前述第1發明之含脂溶性物質之粉末組成物。 According to a third aspect of the present invention, in a food or drink, a powder composition containing the fat-soluble substance according to the first aspect of the invention is blended.

根據本發明，當將以粉末飲料等溶解於水中為特徵之食物溶解於水中後，脂溶性物質能够分散於水中時不會因脂溶性物質導致渾濁。另根據本發明，由於脂溶 性物質之粒子於粉末化後固化至賦形劑中，是故於進行乳劑化或可溶化等時，能够防止液狀組成物發生該粒子之凝聚、合併等問題，該粒子於被添加之食物中能夠長期維持分散安定性。另外，前述粒子之分散安定性能夠於酸性水溶液及高離子強度之水溶液中、或者當溶解於水中時產生酸性或高離子強度之水溶液之粉末飲料、粉末湯料中，以及將其溶解於水中生成之水溶液中長期得以維持。 According to the present invention, when a food characterized by dissolving a powdered beverage or the like in water is dissolved in water, the fat-soluble substance can be dispersed in water without causing turbidity due to the fat-soluble substance. According to the invention, due to fat dissolution When the particles of the substance are solidified into the excipient after pulverization, it is possible to prevent the liquid composition from agglomerating and merging the particles when the emulsion is melted or solubilized, and the particles are added to the food. It can maintain dispersion stability for a long time. Further, the dispersion stability of the particles can be generated in an acidic aqueous solution and an aqueous solution having a high ionic strength, or in a powdered beverage or a powder soup which produces an acidic or high ionic strength aqueous solution when dissolved in water, and is dissolved in water. The aqueous solution is maintained for a long time.

以下關於本發明之含脂溶性物質之粉末組成物(下稱「粉末組成物」。)之實施方式進行說明。如前所述，本發明之粉末組成物之必須成分包含：(a)脂溶性物質，(b)HLB值11為以上之脂肪酸蔗糖酯，(c)離子性之兩親媒性物質，(d)糖類或者糖醇。 Hereinafter, an embodiment of the powder composition of the fat-soluble substance of the present invention (hereinafter referred to as "powder composition") will be described. As described above, the essential components of the powder composition of the present invention comprise: (a) a fat-soluble substance, (b) a fatty acid sucrose ester having an HLB value of 11 or more, (c) an ionic two-parent substance, (d) ) sugar or sugar alcohol.

本發明所使用之(a)脂溶性物質中包含1種脂溶性物質或者2種以上之脂溶性物質之混合物，其純度和混合方法並無特別限制。另外，脂溶性物質以具有於100℃以下成為均勻溶液之溫度，亦即融點為100℃以下為佳，尤其是為了調製當分散於水中時取得高透明度之水溶液之粉末組成物，融點係95℃以下為佳，如融點係90℃以下則更佳。如果係含有融點超過100℃之脂溶性物質之混合物，則經調節使該混合物全體之融點位於上述溫度範圍為佳。 The (a) fat-soluble substance used in the present invention contains one type of fat-soluble substance or a mixture of two or more types of fat-soluble substances, and the purity and mixing method thereof are not particularly limited. Further, the fat-soluble substance preferably has a temperature of 100 ° C or less to form a homogeneous solution, that is, a melting point of 100 ° C or less, particularly for preparing a powder composition of an aqueous solution which achieves high transparency when dispersed in water, and a melting point system. It is preferably 95 ° C or less, and it is more preferable if the melting point is 90 ° C or less. If it is a mixture containing a fat-soluble substance having a melting point of more than 100 ° C, it is preferred that the melting point of the entire mixture is in the above temperature range.

融點100℃以下之脂溶性物質可舉輔酶Q10、 維生素E、蝦青素、甘蔗原素、脂肪酸三酸甘油酯等。 The fat-soluble substance with a melting point of 100 ° C or less can be referred to as coenzyme Q10. Vitamin E, astaxanthin, sugar cane, fatty acid triglyceride, and the like.

另外，脂溶性物質之混合物可舉：上述脂溶性物質中之兩種以上之組合、以及融點係100℃以上之脂溶性物質和上述脂溶性物質之組合，從而於100℃以下生成均勻溶液之溫度之物質。如此具有100℃以上之融點之脂溶性物質可舉葉黃素、β-胡蘿蔔素、芝麻素等。 Further, the mixture of the fat-soluble substances may be a combination of two or more of the above-mentioned fat-soluble substances, and a combination of a fat-soluble substance having a melting point of 100 ° C or higher and the above-mentioned fat-soluble substance, thereby forming a uniform solution at 100 ° C or lower. Temperature substance. Examples of the fat-soluble substance having a melting point of 100 ° C or higher include lutein, β-carotene, and sesamin.

本發明之粉末組成物中之脂溶性物質之含量並無特別限制，唯以0.01質量百分比~40質量百分比為佳。這是因為，如低於0.01質量百分比則因粉末組成物中之脂溶性物質之含量减少是故不實用，而如果超過40質量百分比則於其中一個製造步驟亦即噴霧乾燥步驟容易發生脂溶性物質油滴凝聚及合併。 The content of the fat-soluble substance in the powder composition of the present invention is not particularly limited, and is preferably 0.01% by mass to 40% by mass. This is because, if it is less than 0.01% by mass, it is not practical because the content of the fat-soluble substance in the powder composition is reduced, and if it exceeds 40% by mass, the fat-soluble substance is liable to occur in one of the manufacturing steps, that is, the spray drying step. Oil droplets are condensed and combined.

將本發明之粉末組成物溶解於水中時，為了粉碎前述脂溶性物質使得含前述脂溶性物質之分散粒子以動態光散射法所測定之平均粒徑為10nm以上且150nm以下，可採用乳化劑(b)HLB值係11以上之脂肪酸蔗糖酯。為了充分覆蓋疏水性強脂溶性物質之油滴表面，尤其對於(b)成分全體，採用50質量百分比以上之HLB15以上者為佳。另外為了不劣化本發明之粉末組成物之味道，對於(b)成分全體，採用蔗糖硬脂酸酯、蔗糖油酸酯、蔗糖軟脂酸鹽50質量百分比以上為佳。另外，本發明中HLB值係表示親水性和親油性之間之平衡之數值，可依計算值或者藉由乳化試驗求出。 When the powder composition of the present invention is dissolved in water, an emulsifier may be used in order to pulverize the fat-soluble substance so that the average particle diameter of the dispersed particles containing the fat-soluble substance measured by a dynamic light scattering method is 10 nm or more and 150 nm or less. b) A fatty acid sucrose ester having an HLB value of 11 or more. In order to sufficiently cover the surface of the oil droplets of the hydrophobic strong fat-soluble substance, it is preferable to use 50% by mass or more of HLB 15 or more, in particular, for the entire component (b). Further, in order to prevent deterioration of the taste of the powder composition of the present invention, it is preferred to use sucrose stearate, sucrose oleate or sucrose palmitate in an amount of 50% by mass or more based on the entire component (b). Further, the HLB value in the present invention means a value which is a balance between hydrophilicity and lipophilicity, and can be obtained from a calculated value or by an emulsification test.

本發明中(b)HLB值為11以上之脂肪酸蔗 糖酯之摻合量，只要於其中一個製造步驟即預備乳化步驟中能够充分减小脂溶性物質之油滴之粒徑則其他並無特別限制，通常，對於脂溶性物質之摻合質量為0.2倍量~1.5倍量。這是因為，如果乳化劑之摻合質量小於脂溶性物質之量之0.2倍量，則多數情况下無法使脂溶性物質之粒徑足够小，另外即使摻合超過1.5倍量亦無有利之效果，相反由於預備乳化時具有發生氣泡發生降低乳化之效果，或者由於乳化劑而導致味道劣化之虞。 In the present invention, (b) fatty acid cane having an HLB value of 11 or more The blending amount of the sugar ester is not particularly limited as long as the particle diameter of the oil droplet of the fat-soluble substance can be sufficiently reduced in one of the manufacturing steps, that is, the preliminary emulsification step. Usually, the blending quality for the fat-soluble substance is 0.2. Multiply ~ 1.5 times the amount. This is because if the blending mass of the emulsifier is less than 0.2 times the amount of the fat-soluble substance, the particle size of the fat-soluble substance cannot be sufficiently small in many cases, and there is no advantageous effect even if the blending amount exceeds 1.5 times. On the contrary, due to the effect of occurrence of bubble generation to reduce emulsification during preliminary emulsification, or deterioration of taste due to emulsifier.

藉由加強靜電斥力，當將本發明之粉末組成 物添加到水、酸性水溶液或者高離子強度水溶液中時產生高度分散安定性，為此採用(c)離子性之兩親媒性物質。離子性之兩親媒性物質並無特別限制，可舉高級脂肪酸鹽(例如硬脂酸鈣)、皂素、卵磷脂、改質卵磷脂、***膠等。其中，尤以卵磷脂及酵素分解卵磷脂為代表之改質卵磷脂能夠有效地提高分散安定性且對味道影響較小，為較佳。 By strengthening the electrostatic repulsion, when the powder of the present invention is composed When the substance is added to water, an acidic aqueous solution or a high ionic strength aqueous solution, a high degree of dispersion stability is produced, and for this purpose, (c) an ionic amphiphilic substance is used. The ionic two-agent substance is not particularly limited, and examples thereof include higher fatty acid salts (for example, calcium stearate), saponin, lecithin, modified lecithin, and gum arabic. Among them, modified lecithin represented by lecithin and enzyme decomposition lecithin can effectively improve dispersion stability and have less influence on taste, and is preferable.

本發明之粉末組成物中之離子性之兩親媒性 物質之含量，通常為0.1質量百分比~10質量百分比。如低於0.1質量百分比，則幾乎不產生所述分散安定性，但如超過10質量百分比則可能由於該兩親媒性物質導致味道劣化。 Two ionic affinities in the powder composition of the present invention The content of the substance is usually from 0.1% by mass to 10% by mass. If it is less than 0.1% by mass, the dispersion stability is hardly generated, but if it exceeds 10% by mass, the taste may be deteriorated due to the amphiphilic substance.

(d)糖類或者糖醇具有賦形劑之功能，另外 於製造本發明之粉末組成物時噴霧乾燥預備乳化液時，(d)糖類或者糖醇能夠將脂溶性物質固定以防止脂溶性 物質之油滴凝聚、合併。該糖類可舉海藻糖、砂糖、麥牙糖、葡萄糖、左旋糖、巴拉金糖等，該糖醇類則可舉山梨糖醇、赤蘚糖醇、甘露糖醇、巴糖醇等。此等可單獨或者組合兩種以上後添加。 (d) saccharides or sugar alcohols have the function of excipients, in addition When the preparation of the powder composition of the present invention is spray-dried, the (d) sugar or sugar alcohol can fix the fat-soluble substance to prevent fat solubility. The oil droplets of the substance are condensed and combined. The saccharide may, for example, be trehalose, granulated sugar, maltose, glucose, levulose or palatinose, and the sugar alcohol may be sorbitol, erythritol, mannitol or boritol. These may be added singly or in combination of two or more.

於本發明中，對於糖類或者糖醇類之含量並 無特別限制，本發明之粉末組成物中較佳含量係40質量百分比以上。如不足40質量百分比，有可能於噴霧乾燥時脂溶性物質之油滴發生凝聚、合併，當將粉末組成物溶解於水中時無法使含有脂溶性物質之分散粒子之平均粒徑成為150nm以下。 In the present invention, for the content of sugars or sugar alcohols There is no particular limitation, and a preferred content of the powder composition of the present invention is 40% by mass or more. When the amount is less than 40% by mass, oil droplets of the fat-soluble substance may be aggregated and combined during spray drying, and when the powder composition is dissolved in water, the average particle diameter of the dispersed particles containing the fat-soluble substance may not be 150 nm or less.

本發明之粉末組成物中，除上述成分(a)~ (d)以外，於不妨礙本發明之效果之範圍內，可任意添加可用於食物之各種材料，例如pH調節劑、安定劑、保存料、色素、功能性材料等。 In the powder composition of the present invention, in addition to the above component (a)~ In addition to (d), various materials usable for food, such as a pH adjuster, a stabilizer, a preservative, a coloring matter, a functional material, and the like, may be arbitrarily added within a range that does not impair the effects of the present invention.

本發明之粉末組成物，於溶解於水中時之含 前述脂溶性物質之分散粒子以動態光散射法所測定之平均粒徑為10nm以上且150nm以下。如平均粒徑超過150nm，則當將粉末組成物溶解於水中時粗大粒子可能導致光散射，使溶解液發生渾濁。而製造平均粒徑不足10nm粉末組成物有困難，而且難以維持安定狀態。 The powder composition of the present invention, when dissolved in water The average particle diameter of the dispersed particles of the fat-soluble substance measured by a dynamic light scattering method is 10 nm or more and 150 nm or less. If the average particle diameter exceeds 150 nm, coarse particles may cause light scattering when the powder composition is dissolved in water, causing turbidity of the solution. It is difficult to produce a powder composition having an average particle diameter of less than 10 nm, and it is difficult to maintain a stable state.

本發明之粉末組成物之製造方法具有下述(1)~(4)之步驟：(1)於水系溶劑中混合HLB值11以上之脂肪酸蔗糖酯以取得水相部份之步驟； (2)融化脂溶性物質以取得油相部份之步驟；(3)將前述油相部份混合至前述水相部份中，於80℃以上之環境下進行乳化以取得預備乳化液之步驟；(4)將前述預備乳化液進行噴霧乾燥以取得粉末組成物之步驟。 The method for producing a powder composition of the present invention comprises the following steps (1) to (4): (1) a step of mixing a fatty acid sucrose ester having an HLB value of 11 or more in an aqueous solvent to obtain an aqueous phase portion; (2) a step of melting the fat-soluble substance to obtain an oil phase portion; (3) a step of mixing the oil phase portion into the aqueous phase portion and emulsification at 80 ° C or higher to obtain a preliminary emulsion (4) a step of subjecting the aforementioned preliminary emulsion to spray drying to obtain a powder composition.

於步驟(1)中，於水系溶劑中添加乳化劑(b)HLB值11以上之脂肪酸蔗糖酯，另根據需要添加水溶性分散輔助劑、糖類或者糖醇類等，於加溫之同時進行攪拌混合以調製出均勻之水相部份。此時，加溫溫度只須使所述脂肪酸蔗糖酯以及糖類或者糖醇類等均勻溶解或者分散即可，當蔗糖軟脂酸鹽以及/或者蔗糖硬脂酸酯用做所述脂肪酸蔗糖酯時加溫至70~90℃為佳。攪拌方法並無特別限制，採用螺旋漿式攪拌機、均質機及均勻器等有助於處理時間故較佳。 In the step (1), an emulsifier (b) a fatty acid sucrose ester having an HLB value of 11 or more is added to the aqueous solvent, and a water-soluble dispersing aid, a saccharide or a sugar alcohol is added as needed, and the mixture is stirred while being heated. Mix to prepare a uniform aqueous phase portion. In this case, the heating temperature is only required to uniformly dissolve or disperse the fatty acid sucrose ester, sugar or sugar alcohol, etc., when sucrose palmitate and/or sucrose stearate is used as the fatty acid sucrose ester. Heating to 70~90 °C is preferred. The stirring method is not particularly limited, and it is preferred to use a propeller mixer, a homogenizer, a homogenizer, etc. to contribute to the treatment time.

於步驟(1)中採用之水系溶劑係水和水溶性溶劑之統稱，具體分為僅由水組成者、僅由水溶性溶劑組成者以及同時使用水和水溶性溶劑者。水溶性溶劑可舉乙醇。水溶性溶劑可使用1種，亦可兩種以上並用。 The water-based solvent-based water and the water-soluble solvent used in the step (1) are collectively referred to as those composed only of water, only water-soluble solvents, and water and water-soluble solvents. The water-soluble solvent may be ethanol. One type of the water-soluble solvent may be used, or two or more types may be used in combination.

本發明中採用之水系溶劑以水為佳。此時可添加醇類、糖類或者糖醇類以調節界面張力、以及輔助溶解脂肪酸蔗糖酯。醇類可舉乙醇、甘油、丙二醇；糖類可舉海藻糖、砂糖、麥牙糖、葡萄糖、左旋糖、巴拉金糖等；糖醇類可舉山梨糖醇、赤蘚糖醇、甘露糖醇、巴糖醇等。此等可單獨或者組合兩種以上後添加。 The aqueous solvent used in the present invention is preferably water. At this time, an alcohol, a saccharide or a sugar alcohol may be added to adjust the interfacial tension and to assist in dissolving the fatty acid sucrose ester. Examples of the alcohol include ethanol, glycerin, and propylene glycol; and the sugars include trehalose, granulated sugar, maltose, glucose, levulose, and palatinose; and sugar alcohols include sorbitol, erythritol, and mannitol. , carbitol, etc. These may be added singly or in combination of two or more.

水系溶劑之摻合量並無特別限制，較佳以對於脂溶性物質以及HLB值11以上之脂肪酸蔗糖酯之合計摻合質量(摻合糖類或者糖醇類時，更進一步包括糖類或者糖醇類之合計摻合質量)係0.5倍量~100倍量為佳。如果不足0.5倍量，則因乳化時難以使脂溶性物質之粒徑足夠小，如果超100倍量則經噴霧乾燥後取得之粉末組成物明顯减少故不實用。另外，於噴霧乾燥時，由於乙醇及水將會揮發，是故此等水系溶劑可以以任意比率摻合，而丙二醇、甘油由於不揮發，殘存於粉末中妨礙粉末之形成，是故此等摻合量以對於脂溶性物質、脂肪酸蔗糖酯(以及糖類或者糖醇類)之合計摻合質量摻合10質量百分比以下為佳。 The blending amount of the aqueous solvent is not particularly limited, and is preferably a blending quality with respect to a fat-soluble substance and a fatty acid sucrose ester having an HLB value of 11 or more (when a sugar or a sugar alcohol is blended, further including a sugar or a sugar alcohol) The total blending mass) is preferably 0.5 times to 100 times. When the amount is less than 0.5 times, it is difficult to make the particle diameter of the fat-soluble substance sufficiently small at the time of emulsification, and if it exceeds 100 times, the powder composition obtained by spray drying is remarkably reduced, which is not practical. In addition, in the case of spray drying, since ethanol and water will volatilize, the aqueous solvent can be blended at any ratio, and propylene glycol and glycerin are not volatile, and remain in the powder to hinder the formation of the powder, so the blending amount is It is preferable to blend 10 mass% or less with the blending mass of the fat-soluble substance, the fatty acid sucrose ester (and a saccharide or a sugar alcohol).

於步驟(2)中，將1種或者2種以上之(a)脂溶性物質與根據需要添加之油溶性乳化劑、分散輔助劑等同時進行混合，於加溫之同時進行攪拌使其融化(或者溶解)以調製出均勻之油相部份。加溫溫度只要超過脂溶性物質之融化溫度則並無特別限制，只要融化時即使加熱至100℃以上，將均勻之油相部份冷卻100℃以下時亦不會使脂溶性物質析出即可。 In the step (2), one or two or more kinds of (a) the fat-soluble substance are mixed with an oil-soluble emulsifier or a dispersing auxiliary agent added as needed, and the mixture is stirred and melted while being heated ( Or dissolve) to prepare a homogeneous portion of the oil phase. The heating temperature is not particularly limited as long as it exceeds the melting temperature of the fat-soluble substance, and even if it is heated to 100 ° C or higher during melting, the homogeneous oil phase portion is cooled to 100 ° C or less, and the fat-soluble substance is not precipitated.

於步驟(3)中，藉由將步驟(1)取得之水相部份以及步驟(2)取得之油相部份進行混合、攪拌及乳化以取得油相部份分散於水相部份之預備乳化液。攪拌條件並無特別限制，但為了縮短處理時間最大限度發揮所用之攪拌機及乳化機之能力為佳。另外，亦可使用高壓均 質機及微射流均質機對已用攪拌機及乳化機進行乳化處理之液體進一步進行處理。 In the step (3), the oil phase portion obtained in the step (1) and the oil phase portion obtained in the step (2) are mixed, stirred and emulsified to obtain an oil phase portion dispersed in the water phase portion. Prepare the emulsion. The stirring condition is not particularly limited, but it is preferable to maximize the processing time to maximize the capabilities of the mixer and the emulsifier used. In addition, you can also use high pressure The machine and the micro-jet homogenizer further process the liquid which has been emulsified by the mixer and the emulsifier.

乳化處理時亦可使用任意攪拌機、乳化機。 例如可使用攪拌翼、均質機、高剪力攪拌機、高壓均質機、微射流均質機進行乳化。 Any mixer or emulsifier can also be used for the emulsification treatment. For example, emulsification can be carried out using a stirring wing, a homogenizer, a high shear mixer, a high pressure homogenizer, and a micro jet homogenizer.

於本發明中，使用高剪力攪拌機、均質機、 高壓均質機、微射流均質機進行乳化為佳，從實用角度採用粉碎處理為佳。例如較實用之方法係，用均質機進行預備乳化後再用高壓均質機進行粉碎。步驟(3)中之攪拌條件以及使用高壓均質機等時之條件，由於根據脂溶性物質之狀態、攪拌機以及高壓均質機之形狀、設備之運轉條件等之不同不能一概而定，但藉由實驗觀察乳化粒子之粒徑之變化可容易找到最佳條件。 In the present invention, a high shear mixer, a homogenizer, High-pressure homogenizer and micro-jet homogenizer are preferred for emulsification, and pulverization treatment is preferred from a practical point of view. For example, a more practical method is to perform preliminary emulsification with a homogenizer and then pulverize with a high pressure homogenizer. The stirring conditions in the step (3) and the conditions for using the high-pressure homogenizer or the like are not always determined depending on the state of the fat-soluble substance, the shape of the agitator, the high-pressure homogenizer, and the operating conditions of the apparatus, but by experiment Observing the change in the particle size of the emulsified particles makes it easy to find the optimum conditions.

於步驟(3)中，為提高乳化之效果及减小脂 溶性物質之油滴之粒徑，進行乳化時之溫度係80℃以上。藉由加熱至80℃以上，可以明顯提高脂肪酸蔗糖酯之乳化效果。對於完成乳化之液體亦可添加糖類或者糖醇類、分散輔助劑、乳化劑。尤其於第1步驟中如不添加糖類或者糖醇類時以乳化後添加為佳。 In step (3), in order to improve the effect of emulsification and reduce fat The particle size of the oil droplets of the soluble substance is 80 ° C or higher at the time of emulsification. By heating to above 80 ° C, the emulsification effect of the fatty acid sucrose ester can be significantly improved. For the liquid to be emulsified, sugars or sugar alcohols, dispersion aids, and emulsifiers may be added. In particular, in the first step, it is preferred to add it after emulsification if no sugar or sugar alcohol is added.

本發明之粉末組成物於步驟(3)中進行乳化時，重要的是調製使得以動態光散射法所測定之預備乳化液中之乳化粒子之平均粒徑為10nm以上且150nm以下。這是因為，將噴霧乾燥後取得之粉末組成物溶解於水中後，此時包含脂溶性物質之分散粒子之平均粒徑大體相同 於乳化時之乳化粒子之平均粒徑(或者略减小)，因此於步驟(3)中須將乳化時乳化粒子之平均粒徑微細化至150nm以下，否則噴霧乾燥後取得之粉末組成物溶解於水中時，無法確保含有所述脂溶性物質之分散粒子之平均粒徑10nm以上且150nm以下，其結果，粗大粒子將導致光之散射，從而可能導致粉末組成物溶解液發生渾濁。於步驟(3)中進行乳化時之乳化粒子之平均粒徑120nm以下為更佳，進一步地，100nm以下則更佳。尤其是微細化到100nm以下對於减少光之散射以及提高分散於水時之安定性亦有裨益。而製造平均粒徑不足10nm者有困難，而且難以維持安定狀態。 When the powder composition of the present invention is emulsified in the step (3), it is important that the average particle diameter of the emulsified particles in the preliminary emulsion measured by the dynamic light scattering method is 10 nm or more and 150 nm or less. This is because, after the powder composition obtained by spray drying is dissolved in water, the average particle diameter of the dispersed particles containing the fat-soluble substance is substantially the same. The average particle diameter of the emulsified particles at the time of emulsification (or slightly decreased), so in the step (3), the average particle diameter of the emulsified particles during emulsification should be made fine to 150 nm or less, otherwise the powder composition obtained after spray drying is dissolved in In the case of water, the average particle diameter of the dispersed particles containing the fat-soluble substance cannot be ensured to be 10 nm or more and 150 nm or less. As a result, coarse particles cause scattering of light, which may cause turbidity of the powder composition solution. The average particle diameter of the emulsified particles at the time of emulsification in the step (3) is preferably 120 nm or less, and more preferably 100 nm or less. In particular, miniaturization to below 100 nm is also beneficial for reducing light scattering and improving the stability when dispersed in water. It is difficult to manufacture an average particle diameter of less than 10 nm, and it is difficult to maintain a stable state.

於本發明之步驟(4)中，利用噴霧乾燥設備 將步驟(3)取得之預備乳化液進行粉末化以取得粉末組成物。噴霧乾燥條件並無特別限制，為了縮短處理時間，將入口溫度設為高溫，且加大供應液之流量為佳。另外，為了降低所取得之粉末組成物之附著性，以及提高所包含之脂溶性物質之安定性，將出口溫度調節為60℃~100℃為佳。 In the step (4) of the present invention, using a spray drying device The preliminary emulsion obtained in the step (3) is powdered to obtain a powder composition. The spray drying conditions are not particularly limited, and in order to shorten the treatment time, the inlet temperature is set to a high temperature, and the flow rate of the supply liquid is preferably increased. Further, in order to lower the adhesion of the obtained powder composition and to improve the stability of the fat-soluble substance to be contained, it is preferred to adjust the outlet temperature to 60 ° C to 100 ° C.

步驟(4)所使用之噴霧乾燥設備只要能够對 預備乳化液進行噴霧、去除預備乳化液中之水分、使組成物形成為細顆粒，其他並並無特別限制。噴霧機構可採用碟式者亦可採用噴霧射嘴式者。 The spray drying equipment used in the step (4) is only capable of The preliminary emulsion is sprayed, the moisture in the preliminary emulsion is removed, and the composition is formed into fine particles, and the others are not particularly limited. The spray mechanism can be either a dish or a spray nozzle.

預備乳化液之噴霧乾燥條件，由於預備乳化 液之狀態、設備之尺寸及形狀不同不能一概而定，但可藉 由實驗觀察粉末組成物之粒徑之生成量可容易找到最佳條件。 Spray drying conditions of the prepared emulsion due to preliminary emulsification The state of the liquid, the size and shape of the equipment can not be determined, but can be borrowed It is easy to find the optimum conditions by experimentally observing the amount of the particle size of the powder composition.

另外，本發明司製造方法於步驟(1)~(3)其中之一之步驟中包括(c)添加、混合離子性之兩親媒性物質之過程。因此，例如，如果步驟(3)中係包括添加、混合離子性之兩親媒性物質過程，步驟(3)則係向所述水相部份添加混合所述油相部份和離子性之兩親媒性物質，於80℃以上環境中進行乳化以取得預備乳化液，或者於所述水相部份混合所述油相部份，於80℃以上進行乳化後，添加、混合離子性之兩親媒性物質以取得預備乳化液之步驟。離子性之兩親媒性物質亦可以分為數次添加。另外，離子性之兩親媒性物質亦可直接混合到步驟(4)之噴霧乾燥後之粉末組成物中。 Further, the manufacturing method of the present invention includes the step of (c) adding and mixing the ionic two affinities in the step of one of the steps (1) to (3). Therefore, for example, if the step (3) includes adding and mixing an ionic two-agent substance process, the step (3) adds a mixture of the oil phase portion and the ionicity to the aqueous phase portion. The amphiphilic substance is emulsified in an environment of 80 ° C or higher to obtain a preliminary emulsion, or the oil phase portion is mixed in the aqueous phase portion, and after emulsification at 80 ° C or higher, the ionic property is added and mixed. An amphiphilic material to obtain a preliminary emulsion. The ionic two carbophilic substances can also be added in several additions. Further, the ionic two carbophilic substance may be directly mixed into the spray-dried powder composition of the step (4).

另外，於本發明之製造方法之步驟(1)~(3)其中之一步驟中係包括添加、混合(d)糖類或者糖醇之過程。因此，例如，如果步驟(3)中係包括添加、混合糖類或者糖醇之過程，步驟(3)則係向所述水相部份添加混合所述油相部份和糖類或者糖醇，於80℃以上環境中進行乳化以取得預備乳化液，或者於所述水相部份混合所述油相部份，於80℃以上環境進行乳化後，添加、混合糖類或者糖醇以取得預備乳化液之步驟。尤其是於步驟(1)或者(2)中包括添加、混合糖類或者糖醇類之過程，則對於調節界面張力及溶解乳化劑具有輔助效果，係較佳。糖類或者糖醇亦可以分為數次添加。 Further, in one of the steps (1) to (3) of the production method of the present invention, the process of adding or mixing (d) a saccharide or a sugar alcohol is included. Therefore, for example, if the step (3) includes a process of adding or mixing a sugar or a sugar alcohol, the step (3) is adding a mixture of the oil phase portion and a sugar or a sugar alcohol to the aqueous phase portion. Emulsification in an environment of 80 ° C or higher to obtain a preliminary emulsion, or mixing the oil phase portion in the aqueous phase portion, and emulsification in an environment of 80 ° C or higher, adding or mixing a sugar or a sugar alcohol to obtain a preliminary emulsion The steps. In particular, the process of adding or mixing a saccharide or a sugar alcohol in the step (1) or (2) is preferred for adjusting the interfacial tension and dissolving the emulsifier. Sugars or sugar alcohols can also be added in several times.

藉由上述製造方法能够取得本發明之粉末組 成物，亦即向水、酸性水溶液以及高離子強度水溶液進行分散時之脂溶性物質之平均粒徑相比預備乳化液中之脂溶性物質之平均粒徑同等或者更小。亦即，該粉末組成物當溶解於水、酸性水溶液或者高離子強度水溶液時，能够複元為平均粒徑10nm~150nm之脂溶性物質之分散有乳化粒子之乳液。 The powder group of the present invention can be obtained by the above manufacturing method The average particle diameter of the fat-soluble substance when the product is dispersed in water, an acidic aqueous solution, and a high ionic strength aqueous solution is equal to or smaller than the average particle diameter of the fat-soluble substance in the preliminary emulsion. That is, when the powder composition is dissolved in water, an acidic aqueous solution or a high ionic strength aqueous solution, it can be recovered into an emulsion in which emulsified particles are dispersed as a fat-soluble substance having an average particle diameter of 10 nm to 150 nm.

本發明之粉末組成物可直接作為食品經口攝 取，亦可摻合到果汁飲料、茶、咖啡、牛奶、乳飲料、乳酸菌飲料及含醇飲料等飲料類、以及同樣之粉末飲料類、果凍及軟糖、冰淇淋、酸奶、果醬、飴糖、口香糖、巧克力、小甜餅、餅乾及蛋糕等點心類；砂糖及蜂蜜、水飴等糖類；或者醬油及調味醬、蛋黃醬及沙拉醬等調料類；玉米湯及清湯等湯類及同樣之粉末湯料類；火腿、德式香腸及魚板等加工食品；醬菜及麵類；麵包及米飯等多種食品中。 The powder composition of the invention can be directly used as a food oral shot It can also be blended into juice drinks, tea, coffee, milk, milk drinks, lactic acid bacteria drinks and alcoholic beverages, as well as the same powdered beverages, jelly and jelly, ice cream, yogurt, jam, sugar, chewing gum. , chocolates, cookies, biscuits and cakes; snacks such as sugar, honey, and leeches; or seasonings such as soy sauce and sauces, mayonnaise and salad dressing; soups such as corn soup and broth, and the same powder soup Class; processed foods such as ham, German sausage and fish board; pickles and noodles; bread and rice.

〔實施例〕 [Examples]

以下例舉實施例對於本發明進行更進一步具體地說明，但本發明並非僅受限於實施例。 The invention is further illustrated by the following examples, but the invention is not limited to the examples.

(實施例1) (Example 1)

於200g水中分散蔗糖棕櫚酸單酯(三菱化學食品公司生產，RYOTO蔗糖酯P-1670，商品名)7.5g，於80℃ 下加熱溶解以作為水相部份。另一方面，作為脂溶性物質，將輔酶Q10 5g於80℃下加熱融化後以作為油相部份。然後混合所述水相部份和油相部份，採用Primix社製造之均質機於99℃下進行乳化。乳化後，添加脫脂酸卵磷脂(TSUJI製油公司生產，SLP-白色溶液，商品名)2.5g，充分溶解。確認溶解後添加海藻糖35g進行溶解。 將藉由以上操作取得之預備乳化液使用噴霧乾燥器(大川原化工機公司生產，SPRAYDRYERmodel：L-8i，商品名)進行噴霧乾燥以取得粉末組成物。噴霧乾燥時之條件為：超霧粉碎機轉數30000rpm，入口溫度145℃，出口溫度80℃，供應液之流量為30mL/分。用水稀釋該粉末組成物所成之液中之輔酶Q10粒子之平均粒徑，以動態光散射法測定之結果係80nm。 Disperse sucrose palmitic acid monoester (produced by Mitsubishi Chemical Food Co., Ltd., RYOTO sucrose ester P-1670, trade name) 7.5 g in 200 g of water at 80 ° C It is heated and dissolved to serve as a part of the aqueous phase. On the other hand, as a fat-soluble substance, 5 g of coenzyme Q10 was heated and melted at 80 ° C to obtain an oil phase portion. Then, the aqueous phase portion and the oil phase portion were mixed, and emulsified at 99 ° C using a homogenizer manufactured by Primix. After emulsification, 2.5 g of defatted acid lecithin (manufactured by TSUJI Oil Co., Ltd., SLP-white solution, trade name) was added, and it was sufficiently dissolved. After confirming dissolution, 35 g of trehalose was added and dissolved. The preliminary emulsion obtained by the above operation was spray-dried using a spray dryer (produced by Okawara Chemical Co., Ltd., SPRAYDRYER model: L-8i, trade name) to obtain a powder composition. The conditions for spray drying were as follows: the ultra-mist pulverizer had a number of revolutions of 30,000 rpm, an inlet temperature of 145 ° C, an outlet temperature of 80 ° C, and a flow rate of the supply liquid of 30 mL/min. The average particle diameter of the coenzyme Q10 particles in the liquid of the powder composition was diluted with water, and the result was measured by a dynamic light scattering method to be 80 nm.

(實施例2) (Example 2)

於50g水中分散蔗糖棕櫚酸單酯(CompassFoodsPtE Ltd社生產，HaboMonoesterP90，商品名)1.95g及42.5g海藻糖，於80℃下加熱溶解作為水相部份。另一方面，作為脂溶性物質，混合輔酶Q10 5g、卵磷脂(CompassFoodsPtE Ltd社製造，HaboSL，商品名)0.53g，於80℃下加熱融化混合以作為油相部份。然後混合所述水相部份和油相部份，採用Primix社製均質機於81℃下進行乳化。將藉由以上操作取得之預備乳化液使用噴霧乾燥器(大川原化工機公司生產， SPRAYDRYERmodel：L-8i，商品名)進行噴霧乾燥以取得粉末組成物。噴霧乾燥時之條件為：超霧粉碎機轉數30000rpm，入口溫度145℃，出口溫度80℃，供應液之流量為30mL/分。用水稀釋該粉末組成物所成之液中之輔酶Q10粒子之平均粒徑，以動態光散射法測定之結果係90nm。 Sucrose palmitic acid monoester (manufactured by Compass Foods PtE Ltd, HaboMonoester P90, trade name) 1.95 g and 42.5 g of trehalose were dispersed in 50 g of water, and dissolved at 80 ° C as an aqueous phase portion. On the other hand, as a fat-soluble substance, 5 g of coenzyme Q10 and 0.53 g of lecithin (manufactured by Compass Foods PtE Ltd, HaboSL, trade name) were mixed and heated and melted at 80 ° C to obtain an oil phase portion. Then, the aqueous phase portion and the oil phase portion were mixed, and emulsified at 81 ° C using a homomixer manufactured by Primix. The preliminary emulsion obtained by the above operation is produced by a spray dryer (Okawakawa Chemical Co., Ltd., SPRAYDRYER model: L-8i, trade name) was spray dried to obtain a powder composition. The conditions for spray drying were as follows: the ultra-mist pulverizer had a number of revolutions of 30,000 rpm, an inlet temperature of 145 ° C, an outlet temperature of 80 ° C, and a flow rate of the supply liquid of 30 mL/min. The average particle diameter of the coenzyme Q10 particles in the liquid of the powder composition was diluted with water, and the result was measured by a dynamic light scattering method to be 90 nm.

(實施例3) (Example 3)

於200g水中分散蔗糖棕櫚酸單酯(三菱化學食品公司生產，RYOTO蔗糖酯P-1670，商品名)7.5g，於80℃下加熱溶解以作為水相部份。另一方面，作為脂溶性物質，將輔酶Q10 5g於80℃下加熱融化後以作為油相部份。然後混合所述水相部份和油相部份，採用Primix社製均質機於95℃下進行乳化。乳化後，添加脫脂酸卵磷脂(TSUJI製油公司生產，SLP-白色溶液，商品名)2.5g，充分溶解。確認溶解後，添加砂糖35g進行溶解。將藉由以上操作取得之預備乳化液使用噴霧乾燥器(大川原化工機公司生產，SPRAYDRYERmodel：L-8i，商品名)進行噴霧乾燥以取得粉末組成物。噴霧乾燥時之條件為：超霧粉碎機轉數30000rpm，入口溫度145℃，出口溫度80℃，供應液之流量為30mL/分。用水稀釋該粉末組成物所成之液中之輔酶Q10粒子之平均粒徑，以動態光散射法測定之結果係87.5nm。 Sucrose succinate monoester (manufactured by Mitsubishi Chemical Foods Co., Ltd., RYOTO sucrose ester P-1670, trade name) 7.5 g was dispersed in 200 g of water, and dissolved by heating at 80 ° C to obtain an aqueous phase portion. On the other hand, as a fat-soluble substance, 5 g of coenzyme Q10 was heated and melted at 80 ° C to obtain an oil phase portion. Then, the aqueous phase portion and the oil phase portion were mixed, and emulsified at 95 ° C using a homomixer manufactured by Primix. After emulsification, 2.5 g of defatted acid lecithin (manufactured by TSUJI Oil Co., Ltd., SLP-white solution, trade name) was added, and it was sufficiently dissolved. After confirming dissolution, 35 g of granulated sugar was added and dissolved. The preliminary emulsion obtained by the above operation was spray-dried using a spray dryer (produced by Okawara Chemical Co., Ltd., SPRAYDRYER model: L-8i, trade name) to obtain a powder composition. The conditions for spray drying were as follows: the ultra-mist pulverizer had a number of revolutions of 30,000 rpm, an inlet temperature of 145 ° C, an outlet temperature of 80 ° C, and a flow rate of the supply liquid of 30 mL/min. The average particle diameter of the coenzyme Q10 particles in the liquid of the powder composition was diluted with water, and the result by dynamic light scattering was 87.5 nm.

(實施例4) (Example 4)

於200g水中分散蔗糖單硬脂酸酯(第一工業製藥公司生產，DKESTERSS，商品名)7.5g，於80℃下加熱溶解以作為水相部份。另一方面，作為脂溶性物質，將輔酶Q10 5g於80℃下加熱融化後以作為油相部份。然後混合所述水相部份和油相部份，採用Primix社製均質機於95℃下進行乳化。乳化後，添加脫脂酸卵磷脂(TSUJI製油公司生產，SLP-白色溶液，商品名)2.5g，充分溶解。確認溶解後添加海藻糖35g進行溶解。將藉由以上操作取得之預備乳化液使用噴霧乾燥器(大川原化工機公司生產，SPRAYDRYERmodel：L-8i，商品名)進行噴霧乾燥以取得粉末組成物。噴霧乾燥時之條件為：超霧粉碎機轉數30000rpm，入口溫度145℃，出口溫度80℃，供應液之流量為30mL/分。用水稀釋該粉末組成物所成之液中之輔酶Q10粒子之平均粒徑，以動態光散射法測定之結果係84nm。 Sucrose monostearate (manufactured by First Industrial Pharmaceutical Co., Ltd., DKESTERSS, trade name) 7.5 g was dispersed in 200 g of water, and dissolved by heating at 80 ° C to obtain an aqueous phase portion. On the other hand, as a fat-soluble substance, 5 g of coenzyme Q10 was heated and melted at 80 ° C to obtain an oil phase portion. Then, the aqueous phase portion and the oil phase portion were mixed, and emulsified at 95 ° C using a homomixer manufactured by Primix. After emulsification, 2.5 g of defatted acid lecithin (manufactured by TSUJI Oil Co., Ltd., SLP-white solution, trade name) was added, and it was sufficiently dissolved. After confirming dissolution, 35 g of trehalose was added and dissolved. The preliminary emulsion obtained by the above operation was spray-dried using a spray dryer (produced by Okawara Chemical Co., Ltd., SPRAYDRYER model: L-8i, trade name) to obtain a powder composition. The conditions for spray drying were as follows: the ultra-mist pulverizer had a number of revolutions of 30,000 rpm, an inlet temperature of 145 ° C, an outlet temperature of 80 ° C, and a flow rate of the supply liquid of 30 mL/min. The average particle diameter of the coenzyme Q10 particles in the liquid of the powder composition was diluted with water, and the result was measured by a dynamic light scattering method to be 84 nm.

(實施例5) (Example 5)

於50g水中分散蔗糖棕櫚酸單酯(三菱化學食品公司生產，RYOTO蔗糖酯P-1670，商品名)4.0g及35g海藻糖，於80℃下加熱溶解以作為水相部份。另一方面，作為脂溶性物質，將輔酶Q10 10g於80℃下加熱融化以作為油相部份。然後混合所述水相部份和油相部份，採用Primix社製均質機於91℃下進行乳化。乳化後，添加脫 脂酸卵磷脂(TSUJI製油公司生產，SLP-白色溶液，商品名)1.0g，充分溶解。將藉由以上操作取得之預備乳化液使用噴霧乾燥器(大川原化工機公司生產，SPRAYDRYERmodel：L-8i，商品名)進行噴霧乾燥以取得粉末組成物。噴霧乾燥時之條件為：超霧粉碎機轉數30000rpm，入口溫度145℃，出口溫度80℃，供應液之流量為30mL/分。用水稀釋該粉末組成物所成之液中之輔酶Q10粒子之平均粒徑，以動態光散射法測定之結果係96nm。 Sucrose palmitic acid monoester (manufactured by Mitsubishi Chemical Food Co., Ltd., RYOTO sucrose ester P-1670, trade name) 4.0 g and 35 g of trehalose were dispersed in 50 g of water, and dissolved by heating at 80 ° C to obtain an aqueous phase portion. On the other hand, as a fat-soluble substance, 10 g of coenzyme Q10 was heated and melted at 80 ° C to serve as an oil phase portion. Then, the aqueous phase portion and the oil phase portion were mixed, and emulsified at 91 ° C using a homomixer manufactured by Primix. After emulsification, add off Fatty acid lecithin (produced by TSUJI Oil Co., Ltd., SLP-white solution, trade name) 1.0 g, fully dissolved. The preliminary emulsion obtained by the above operation was spray-dried using a spray dryer (produced by Okawara Chemical Co., Ltd., SPRAYDRYER model: L-8i, trade name) to obtain a powder composition. The conditions for spray drying were as follows: the ultra-mist pulverizer had a number of revolutions of 30,000 rpm, an inlet temperature of 145 ° C, an outlet temperature of 80 ° C, and a flow rate of the supply liquid of 30 mL/min. The average particle diameter of the coenzyme Q10 particles in the liquid of the powder composition was diluted with water, and the result was measured by a dynamic light scattering method to be 96 nm.

(實施例6) (Example 6)

於50g水中分散蔗糖棕櫚酸單酯(三菱化學食品公司生產，RYOTO蔗糖酯P-1670，商品名)1.95g及42.5g海藻糖，於80℃下加熱溶解以作為水相部份。另一方面，作為脂溶性物質，於80℃加热中鏈三酸甘油脂(花王公司製造，COCONARD MT，商品名)5g作為油相部份。然後混合所述水相部份和油相部份，採用Primix社製均質機於83℃下進行乳化。乳化後，添加脫脂酸卵磷脂(TSUJI製油公司生產，SLP-白色溶液，商品名)0.5g，充分溶解。將藉由以上操作取得之預備乳化液使用噴霧乾燥器(大川原化工機公司生產，SPRAYDRYERmodel：L-8i，商品名)進行噴霧乾燥以取得粉末組成物。噴霧乾燥時之條件為：超霧粉碎機轉數30000rpm，入口溫度145℃，出口溫度80℃，供應液之流量為30mL/分。用水稀 釋該粉末組成物所成之液中之輔酶Q10粒子之平均粒徑，以動態光散射法測定之結果係94nm。 Sucrose palmitic acid monoester (manufactured by Mitsubishi Chemical Foods Co., Ltd., RYOTO sucrose ester P-1670, trade name) 1.95 g and 42.5 g of trehalose were dispersed in 50 g of water, and dissolved by heating at 80 ° C to obtain an aqueous phase portion. On the other hand, as a fat-soluble substance, 5 g of medium chain triglyceride (COCONARD MT, trade name) manufactured by Kao Corporation was heated at 80 ° C as an oil phase portion. Then, the aqueous phase portion and the oil phase portion were mixed, and emulsified at 83 ° C using a homomixer manufactured by Primix. After the emulsification, 0.5 g of defatted acid lecithin (manufactured by TSUJI Oil Co., Ltd., SLP-white solution, trade name) was added, and it was sufficiently dissolved. The preliminary emulsion obtained by the above operation was spray-dried using a spray dryer (produced by Okawara Chemical Co., Ltd., SPRAYDRYER model: L-8i, trade name) to obtain a powder composition. The conditions for spray drying were as follows: the ultra-mist pulverizer had a number of revolutions of 30,000 rpm, an inlet temperature of 145 ° C, an outlet temperature of 80 ° C, and a flow rate of the supply liquid of 30 mL/min. Water thin The average particle diameter of the coenzyme Q10 particles in the liquid formed by the powder composition was measured by a dynamic light scattering method and found to be 94 nm.

(實施例7) (Example 7)

於200g水中分散蔗糖棕櫚酸單酯(三菱化學食品公司生產，RYOTO蔗糖酯P-1670，商品名)7.5g及海藻糖42.5g，於80℃下加熱溶解以作為水相部份。另一方面，作為脂溶性物質，於80℃下加熱維生素戊錠5g以作為油相部份。然後混合所述水相部份和油相部份，採用Primix社製均質機於83℃下進行乳化。乳化後，添加脫脂酸卵磷脂(TSUJI製油公司生產，SLP-白色溶液，商品名)2.5g，充分溶解。將藉由以上操作取得之預備乳化液使用噴霧乾燥器(大川原化工機公司生產，SPRAYDRYERmodel：L-8i，商品名)進行噴霧乾燥以取得粉末組成物。噴霧乾燥時之條件為：超霧粉碎機轉數30000rpm，入口溫度145℃，出口溫度80℃，供應液之流量為30mL/分。用水稀釋該粉末組成物所成之液中之維生素戊錠粒子之平均粒徑，以動態光散射法測定之結果係120nm。 Sucrose succinate monoester (manufactured by Mitsubishi Chemical Food Co., Ltd., RYOTO sucrose ester P-1670, trade name) 7.5 g and trehalose 42.5 g were dispersed in 200 g of water, and dissolved at 80 ° C to obtain an aqueous phase portion. On the other hand, as a fat-soluble substance, 5 g of vitamin ingot was heated at 80 ° C to obtain an oil phase portion. Then, the aqueous phase portion and the oil phase portion were mixed, and emulsified at 83 ° C using a homomixer manufactured by Primix. After emulsification, 2.5 g of defatted acid lecithin (manufactured by TSUJI Oil Co., Ltd., SLP-white solution, trade name) was added, and it was sufficiently dissolved. The preliminary emulsion obtained by the above operation was spray-dried using a spray dryer (produced by Okawara Chemical Co., Ltd., SPRAYDRYER model: L-8i, trade name) to obtain a powder composition. The conditions for spray drying were as follows: the ultra-mist pulverizer had a number of revolutions of 30,000 rpm, an inlet temperature of 145 ° C, an outlet temperature of 80 ° C, and a flow rate of the supply liquid of 30 mL/min. The average particle diameter of the vitamin E in the liquid obtained by diluting the powder composition with water was measured by a dynamic light scattering method to be 120 nm.

(比較例1) (Comparative Example 1)

混合輔酶Q10、蔗糖棕櫚酸單酯、海藻糖、脫脂酸卵磷脂，使其摻合與實施例1所得之粉末組成物相同，取得了粉末組成物。用水稀釋所取得之本品所成之液中之輔酶 Q10粒子之平均粒徑，以動態光散射法測定之結果係2530nm。 Coenzyme Q10, sucrose palmitic acid monoester, trehalose, and defatted acid lecithin were mixed and blended with the powder composition obtained in Example 1, to obtain a powder composition. Diluting the coenzyme in the liquid obtained from the product obtained by diluting with water The average particle diameter of the Q10 particles was measured by a dynamic light scattering method to be 2530 nm.

(比較例2) (Comparative Example 2)

於200g水中分散糊精35g、一甘油硬脂酸酯5g、***膠2g、卵磷脂3g，於80℃下加熱溶解以作為水相部份。另一方面，作為脂溶性物質，將輔酶Q10 10g於80℃下加熱融化以作為油相部份。然後混合所述水相部份和油相部份，採用Primix社製均質機於80℃下進行乳化。將藉由以上操作取得之預備乳化液使用噴霧乾燥器(大川原化工機公司生產，SPRAYDRYERmodel：L-8i，商品名)進行噴霧乾燥以取得粉末組成物。噴霧乾燥時之條件為：超霧粉碎機轉數30000rpm，入口溫度145℃，出口溫度80℃，供應液之流量為30mL/分。用水稀釋該粉末組成物所成之液中之輔酶Q10粒子之平均粒徑，以動態光散射法測定之結果係980nm。 35 g of dextrin, 5 g of monoglyceryl stearate, 2 g of gum arabic, and 3 g of lecithin were dispersed in 200 g of water, and dissolved by heating at 80 ° C to obtain an aqueous phase portion. On the other hand, as a fat-soluble substance, 10 g of coenzyme Q10 was heated and melted at 80 ° C to serve as an oil phase portion. Then, the aqueous phase portion and the oil phase portion were mixed, and emulsified at 80 ° C using a homomixer manufactured by Primix. The preliminary emulsion obtained by the above operation was spray-dried using a spray dryer (produced by Okawara Chemical Co., Ltd., SPRAYDRYER model: L-8i, trade name) to obtain a powder composition. The conditions for spray drying were as follows: the ultra-mist pulverizer had a number of revolutions of 30,000 rpm, an inlet temperature of 145 ° C, an outlet temperature of 80 ° C, and a flow rate of the supply liquid of 30 mL/min. The average particle diameter of the coenzyme Q10 particles in the liquid of the powder composition was diluted with water, and the result by dynamic light scattering was 980 nm.

(比較例3) (Comparative Example 3)

於200g水中分散蔗糖棕櫚酸單酯(三菱化學食品公司生產，RYOTO蔗糖酯P-1670，商品名)7.5g、糊精37.5g，於80℃加熱溶解以作為水相部份。另一方面，作為脂溶性物質，將輔酶Q10 5g於80℃下加熱融化後以作為油相部份。然後混合所述水相部份和油相部份，採用Primix社製均質機於95.7℃下進行乳化。將藉由以上操作 取得之預備乳化液使用噴霧乾燥器(大川原化工機公司生產，SPRAYDRYERmodel：L-8i，商品名)進行噴霧乾燥以取得粉末組成物。噴霧乾燥時之條件為：超霧粉碎機轉數30000rpm，入口溫度145℃，出口溫度80℃，供應液之流量為30mL/分。用水稀釋該粉末組成物之液中之輔酶Q10粒子之平均粒徑，以動態光散射法測定之結果係162nm。 Sucrose succinate monoester (manufactured by Mitsubishi Chemical Food Co., Ltd., RYOTO sucrose ester P-1670, trade name) 7.5 g and dextrin 37.5 g were dispersed in 200 g of water, and dissolved by heating at 80 ° C to obtain an aqueous phase portion. On the other hand, as a fat-soluble substance, 5 g of coenzyme Q10 was heated and melted at 80 ° C to obtain an oil phase portion. Then, the aqueous phase portion and the oil phase portion were mixed, and emulsified at 95.7 ° C using a homomixer manufactured by Primix. Will be operated by The obtained preliminary emulsion was spray-dried using a spray dryer (produced by Okawara Chemical Co., Ltd., SPRAYDRYER model: L-8i, trade name) to obtain a powder composition. The conditions for spray drying were as follows: the ultra-mist pulverizer had a number of revolutions of 30,000 rpm, an inlet temperature of 145 ° C, an outlet temperature of 80 ° C, and a flow rate of the supply liquid of 30 mL/min. The average particle diameter of the coenzyme Q10 particles in the liquid of the powder composition was diluted with water, and the result by dynamic light scattering was 162 nm.

(比較例4) (Comparative Example 4)

於50g水中分散蔗糖單硬脂酸酯(第一工業製藥製造，DKESTERSS，商品名)3g、十甘油單月桂酸酯(日光化學公司生產，Decaglyn1-L，商品名)3g、糊精30g、麥牙糖50g，於80℃下加熱溶解以作為水相部份。另一方面，作為脂溶性物質，將輔酶Q10 10g於80℃下加熱融化以作為油相部份。然後混合所述水相部份和油相部份，採用Primix社製均質機於97.6℃下進行乳化。向藉由以上操作取得之預備乳化液中添加30g水均勻混合後採用噴霧乾燥器(大川原化工機公司生產，SPRAYDRYERmodel：L-8i，商品名)進行噴霧乾燥以取得粉末組成物。噴霧乾燥時之條件為：超霧粉碎機轉數30000rpm，入口溫度145℃，出口溫度80℃，供應液之流量為30mL/分。用水稀釋該粉末組成物所成之液中之輔酶Q10粒子之平均粒徑，以動態光散射法測定之結果係230nm。 Disperse sucrose monostearate (first industrial pharmaceutical manufacturing, DKESTERSS, trade name) 3g, decaglyceryl monolaurate (produced by Nikko Chemical Co., Decaglyn 1-L, trade name) 3g, dextrin 30g, wheat Toffee 50 g was dissolved by heating at 80 ° C to serve as an aqueous phase portion. On the other hand, as a fat-soluble substance, 10 g of coenzyme Q10 was heated and melted at 80 ° C to serve as an oil phase portion. Then, the aqueous phase portion and the oil phase portion were mixed, and emulsified at 97.6 ° C using a homomixer manufactured by Primix. To the preliminary emulsion obtained by the above operation, 30 g of water was uniformly mixed, and then spray-dried by a spray dryer (produced by Okawara Chemical Co., Ltd., SPRAYDRYER model: L-8i, trade name) to obtain a powder composition. The conditions for spray drying were as follows: the ultra-mist pulverizer had a number of revolutions of 30,000 rpm, an inlet temperature of 145 ° C, an outlet temperature of 80 ° C, and a flow rate of the supply liquid of 30 mL/min. The average particle diameter of the coenzyme Q10 particles in the solution of the powder composition was diluted with water, and the result by dynamic light scattering was 230 nm.

(比較例5) (Comparative Example 5)

於200g水中分散十甘油單月桂酸酯(日光化學公司生產，Decaglyn1-L，商品名)7.5g，於80℃下加熱溶解以作為水相部份。另一方面，作為脂溶性物質，將輔酶Q10 5g於80℃下加熱融化後以作為油相部份。然後混合所述水相部份和油相部份，採用Primix社製均質機於99.7℃下進行乳化。然後，脫脂酸卵磷脂(TSUJI製油公司生產，SLP-白色溶液，商品名)2.5g添加充分溶解。確認溶解後添加海藻糖35g進行溶解。將藉由以上操作取得之預備乳化液使用噴霧乾燥器(大川原化工機公司生產，SPRAYDRYERmodel：L-8i，商品名)進行噴霧乾燥以取得粉末組成物。噴霧乾燥時之條件為：超霧粉碎機轉數30000rpm，入口溫度145℃，出口溫度80℃，供應液之流量為30mL/分。用水稀釋該粉末組成物所成之液中之輔酶Q10粒子之平均粒徑，以動態光散射法測定之結果係615nm。 Disodium tetraglyceride monolaurate (Decaglyn 1-L, trade name) 7.5 g was dispersed in 200 g of water, and dissolved by heating at 80 ° C to obtain a water phase portion. On the other hand, as a fat-soluble substance, 5 g of coenzyme Q10 was heated and melted at 80 ° C to obtain an oil phase portion. Then, the aqueous phase portion and the oil phase portion were mixed, and emulsified at 99.7 ° C using a homomixer manufactured by Primix. Then, 2.5 g of defatted acid lecithin (produced by TSUJI Oil Co., Ltd., SLP-white solution, trade name) was sufficiently dissolved. After confirming dissolution, 35 g of trehalose was added and dissolved. The preliminary emulsion obtained by the above operation was spray-dried using a spray dryer (produced by Okawara Chemical Co., Ltd., SPRAYDRYER model: L-8i, trade name) to obtain a powder composition. The conditions for spray drying were as follows: the ultra-mist pulverizer had a number of revolutions of 30,000 rpm, an inlet temperature of 145 ° C, an outlet temperature of 80 ° C, and a flow rate of the supply liquid of 30 mL/min. The average particle diameter of the coenzyme Q10 particles in the liquid of the powder composition was diluted with water, and the result by dynamic light scattering was 615 nm.

(比較例6) (Comparative Example 6)

於200g水中分散蔗糖棕櫚酸單酯(三菱化學食品公司生產，RYOTO蔗糖酯P-1670，商品名)7.5g，於80℃下加熱溶解以作為水相部份。另一方面，作為脂溶性物質，將輔酶Q10 5g於80℃下加熱融化後以作為油相部份。然後混合所述水相部份和油相部份，採用Primix社製造之均質機於99℃下進行乳化。確認溶解後，添加海 藻糖37.5g進行溶解。將藉由以上操作取得之預備乳化液使用噴霧乾燥器(大川原化工機公司生產，SPRAYDRYERmodel：L-8i，商品名)進行噴霧乾燥以取得粉末組成物。噴霧乾燥時之條件為：超霧粉碎機轉數30000rpm，入口溫度145℃，出口溫度80℃，供應液之流量為30mL/分。用水稀釋該粉末組成物所成之液中之輔酶Q10粒子之平均粒徑，以動態光散射法測定之結果係81nm。 Sucrose succinate monoester (manufactured by Mitsubishi Chemical Foods Co., Ltd., RYOTO sucrose ester P-1670, trade name) 7.5 g was dispersed in 200 g of water, and dissolved by heating at 80 ° C to obtain an aqueous phase portion. On the other hand, as a fat-soluble substance, 5 g of coenzyme Q10 was heated and melted at 80 ° C to obtain an oil phase portion. Then, the aqueous phase portion and the oil phase portion were mixed, and emulsified at 99 ° C using a homogenizer manufactured by Primix. After confirming dissolution, add sea 37.5 g of alginose was dissolved. The preliminary emulsion obtained by the above operation was spray-dried using a spray dryer (produced by Okawara Chemical Co., Ltd., SPRAYDRYER model: L-8i, trade name) to obtain a powder composition. The conditions for spray drying were as follows: the ultra-mist pulverizer had a number of revolutions of 30,000 rpm, an inlet temperature of 145 ° C, an outlet temperature of 80 ° C, and a flow rate of the supply liquid of 30 mL/min. The average particle diameter of the coenzyme Q10 particles in the liquid of the powder composition was diluted with water, and the result was measured by a dynamic light scattering method to be 81 nm.

〔光透過性試驗〕 [Light permeability test] (試驗方法) (experiment method)

採用以下方法對分別添加藉由實施例1~7及比較例1~6取得之粉末組成物飲料組成物實施光透過性試驗。 The powder composition beverage composition obtained in each of Examples 1 to 7 and Comparative Examples 1 to 6 was subjected to a light transmittance test by the following method.

於水99.8g中添加藉由實施例1~7及比較例1~6取得之各粉末組成物0.2g並進行混合，取得了包含所述脂溶性物質20mg/100g之飲料組成物。將此等飲料組成物分別充滿至光路長1cm之玻璃比色槽中，根據用分光器照射波長為680nm之光時之透過光之強度、與照射充入水之玻璃比色槽時之光之透過強度之比，計算出透過率。另外，以動態光散射法測定此等飲料組成物中所含所述脂溶性物質粒子之平均粒徑。 0.2 g of each of the powder compositions obtained in Examples 1 to 7 and Comparative Examples 1 to 6 was added to 99.8 g of water and mixed, and a beverage composition containing the fat-soluble substance of 20 mg/100 g was obtained. The beverage compositions are filled into a glass cuvette having an optical path length of 1 cm, respectively, and the intensity of the transmitted light when irradiated with light having a wavelength of 680 nm by the spectroscope and the transmission of light when irradiated with the glass cuvette filled with water The ratio of the intensities is calculated as the transmittance. Further, the average particle diameter of the fat-soluble substance particles contained in the beverage compositions was measured by a dynamic light scattering method.

另外，用將檸檬酸及檸檬酸鈉調製成pH3之 水溶液，採用與上述相同之方法，於該pH3水溶液中混合藉由實施例1~7及比較例1~6取得之各粉末組成物，取 得了含有20mg/100g所述脂溶性物質之酸性飲料組成物。將此等酸性飲料組成物分別充滿至光路長為1cm之玻璃比色槽中，根據用分光器照射波長為680nm之光時之透過光之強度、與照射充入水之玻璃比色槽時之光之透過強度之比，計算出透過率。 In addition, the citric acid and sodium citrate are adjusted to pH 3 In the aqueous solution, the powder compositions obtained in Examples 1 to 7 and Comparative Examples 1 to 6 were mixed in the pH 3 aqueous solution in the same manner as above. An acidic beverage composition containing 20 mg/100 g of the fat-soluble substance was obtained. The acidic beverage compositions are respectively filled into a glass cuvette having an optical path length of 1 cm, and the intensity of the transmitted light when irradiated with light having a wavelength of 680 nm by the spectroscope and the light when irradiated with the glass cuvette filled with water The transmittance ratio is calculated from the ratio of the transmission intensity.

另外，用溶解1%食鹽之水溶液，採用與上述 相同之方法，於該1%食鹽水中藉由混合藉由實施例1~7及比較例1~6取得之各粉末組成物，取得了含有20mg/100g所述脂溶性物質之高離子強度飲料組成物。將此等高離子強度飲料組成物分別充滿至光路長為1cm之玻璃比色槽中，根據用分光器照射波長為680nm之光時之透過光之強度、與照射充入水之玻璃比色槽時之光之透過強度之比，計算出透過率。 In addition, an aqueous solution in which 1% of the salt is dissolved is used as described above. In the same manner, a high ionic strength beverage composition containing 20 mg/100 g of the fat-soluble substance was obtained by mixing the powder compositions obtained in Examples 1 to 7 and Comparative Examples 1 to 6 in the 1% saline solution. Things. The high ionic strength beverage composition is filled into a glass colorimetric cell having an optical path length of 1 cm, respectively, according to the intensity of the transmitted light when the light having a wavelength of 680 nm is irradiated with the spectroscope, and when the glass colorimetric cell is filled with water. The transmittance ratio of the light is calculated to calculate the transmittance.

(試驗結果) (test results)

如表1所示，將藉由實施例1~7及比較例6取得之粉末組成物摻合於水中飲料組成物透過80%以上之波長為680nm之光。此即表明，將藉由實施例1~7及比較例6取得之粉末組成物溶解於水中後可取得具有高透明度之飲料。 As shown in Table 1, the powder composition obtained in Examples 1 to 7 and Comparative Example 6 was blended into a water beverage composition to transmit light having a wavelength of 680 nm of 80% or more. This indicates that the powder composition obtained in Examples 1 to 7 and Comparative Example 6 was dissolved in water to obtain a beverage having high transparency.

另外如表1所示，將藉由實施例1~7取得之 粉末組成物摻合到將檸檬酸及檸檬酸鈉調節為pH3之水中之酸性飲料組成物透過75%以上波長為680nm之光，透過率未見大幅下降。另一方面，將藉由比較例1~6取得 之粉末組成物摻合到將檸檬酸及檸檬酸鈉調節為pH3之水中之酸性飲料組成物僅透過30%以下之波長為680nm之光。特別是，相比摻合到所述水中時之透過率，於溶解於水中時具有高透明感之比較例6之粉末組成物之透過率减少了約67%。此即表明，摻合到酸性水溶液中時，實施例1~7之粉末組成物之透明度更具優勢。 Further, as shown in Table 1, it will be obtained by the examples 1 to 7. The powder composition was blended into an acidic beverage composition in which water having citric acid and sodium citrate adjusted to pH 3, and transmitted through 75% or more of light having a wavelength of 680 nm, and the transmittance did not significantly decrease. On the other hand, it will be obtained by comparing examples 1 to 6. The powder composition is blended into an acidic beverage composition in which water having citric acid and sodium citrate adjusted to pH 3 is transmitted through only 30% of light having a wavelength of 680 nm. In particular, the transmittance of the powder composition of Comparative Example 6 having a high transparency when dissolved in water was reduced by about 67% compared to the transmittance when blended into the water. This indicates that the transparency of the powder compositions of Examples 1 to 7 is more advantageous when blended into an acidic aqueous solution.

另外如表1所示，將藉由實施例1~7取得之 粉末組成物摻合於1%食鹽水中之高離子強度飲料組成物透過75%以上之波長為680nm之光，透過率未見大幅下降。另一方面，用比較例1~5之方法將粉末組成物摻合於1%食鹽水中之高離子強度飲料組成物僅透過20%以下波長為680nm之光。於溶解於水中時具有高透明感之比較例6之粉末組成物之透過率减少至34.4%。此即表明，於摻合到高離子強度水溶液中時，實施例1~7之粉末組成物之透明度更具優勢。 Further, as shown in Table 1, it will be obtained by the examples 1 to 7. The high ionic strength beverage composition in which the powder composition was blended in 1% saline solution transmitted through 75% or more of light having a wavelength of 680 nm, and the transmittance did not significantly decrease. On the other hand, the high ionic strength beverage composition in which the powder composition was blended in 1% saline solution by the method of Comparative Examples 1 to 5 transmitted only 20% or less of light having a wavelength of 680 nm. The transmittance of the powder composition of Comparative Example 6 which had a high transparency when dissolved in water was reduced to 34.4%. This indicates that the transparency of the powder compositions of Examples 1 to 7 is more advantageous when blended into a high ionic strength aqueous solution.

〔pH安定性試驗〕 [pH stability test] (試驗方法) (experiment method)

將0.2g藉由實施例1取得之粉末組成物摻合到用檸檬酸及檸檬酸鈉分別調製成pH2.3、pH3、pH4、pH5以及pH5.5之水99.8g中，取得了含有20mg/100g所述脂溶性物質之酸性飲料組成物。另一方面，作為對照，用同樣方法取得了摻合於比較例6中取得之粉末組成物之酸性飲料組成物。將此等酸性飲料組成物分別充滿至光路長為1cm之玻璃比色槽中，根據用分光器照射波長為680nm之光時之透過光之強度、與照射充入水之玻璃比色槽時之光 之透過強度之比，計算出透過率。 0.2 g of the powder composition obtained in Example 1 was blended into 99.8 g of water having a pH of 2.3, pH 3, pH 4, pH 5, and pH 5.5, respectively, with citric acid and sodium citrate to obtain 20 mg/ 100 g of the acidic beverage composition of the fat-soluble substance. On the other hand, as a control, an acidic beverage composition blended with the powder composition obtained in Comparative Example 6 was obtained in the same manner. The acidic beverage compositions are respectively filled into a glass cuvette having an optical path length of 1 cm, and the intensity of the transmitted light when irradiated with light having a wavelength of 680 nm by the spectroscope and the light when irradiated with the glass cuvette filled with water The transmittance ratio is calculated from the ratio of the transmission intensity.

(試驗結果) (test results)

如表2所示，摻合了藉由實施例1取得之粉末組成物之酸性飲料組成物，於所述任意pH之酸性水溶液中，均透過90%以上波長680nm之光，保持高透明度。另一方面，摻合了藉由比較例6取得之粉末組成物之酸性飲料組成物，於所述任意pH之酸性水溶液中均僅透過50%以下之波長為680nm之光。此即表明，摻合了實施例1之粉末組成物之酸性水溶液之透過率，於大範圍之pH酸性條件下具有高安定性。 As shown in Table 2, the acidic beverage composition in which the powder composition obtained in Example 1 was blended was passed through 90% or more of light having a wavelength of 680 nm in the acidic aqueous solution of any pH to maintain high transparency. On the other hand, the acidic beverage composition in which the powder composition obtained in Comparative Example 6 was blended was passed through only 50% or less of light having a wavelength of 680 nm in the acidic aqueous solution of any of the above pH. That is, the transmittance of the acidic aqueous solution in which the powder composition of Example 1 was blended was high in stability under a wide range of pH acidic conditions.

〔高離子強度安定性試驗〕 [High ionic strength stability test] (試驗方法) (experiment method)

將藉0.2g由實施例1取得之粉末組成物摻合到99.8g分別溶解了10%、5%、1%以及0.5%之食鹽之水中，取得了含有20mg/100g所述脂溶性物質之高離子強度飲料組成物。另一方面，作為對照，用同樣方法取得了摻合於比 較例6中取得之粉末組成物之高離子強度飲料組成物。將此等高離子強度飲料組成物分別充滿至光路長為1cm之玻璃比色槽中，根據用分光器照射波長為680nm之光時之透過光之強度、與照射充入水之玻璃比色槽時之光之透過強度之比，計算出透過率。 0.2 g of the powder composition obtained in Example 1 was blended into 99.8 g of water in which 10%, 5%, 1%, and 0.5% of the salt was dissolved, respectively, to obtain a high content of 20 mg/100 g of the fat-soluble substance. Ionic strength beverage composition. On the other hand, as a control, the blending ratio was obtained in the same way. A high ionic strength beverage composition of the powder composition obtained in Example 6. The high ionic strength beverage composition is filled into a glass colorimetric cell having an optical path length of 1 cm, respectively, according to the intensity of the transmitted light when the light having a wavelength of 680 nm is irradiated with the spectroscope, and when the glass colorimetric cell is filled with water. The transmittance ratio of the light is calculated to calculate the transmittance.

(試驗結果) (test results)

如表3所示，摻合了藉由實施例1取得之粉末組成物之高離子強度飲料組成物，於任意高離子強度之水溶液中均透過90%以上波長680nm之光，保持高透明度。另一方面，摻合了藉由比較例6取得之粉末組成物之高離子強度飲料組成物，於食鹽濃度0.5%以上時僅透過50%以下之波長680nm之光。另外於食鹽濃度0.1%下透過率為70%左右，與實施例1相比透過率大幅下降從而發生渾濁。此即表明，摻合了實施例1之粉末組成物之高離子強度之水溶液，於大範圍之高離子強度條件下具有高安定性。 As shown in Table 3, the high ionic strength beverage composition in which the powder composition obtained in Example 1 was blended was passed through 90% or more of light having a wavelength of 680 nm in an aqueous solution of any high ionic strength to maintain high transparency. On the other hand, the high ionic strength beverage composition in which the powder composition obtained in Comparative Example 6 was blended was passed through only 50% or less of light having a wavelength of 680 nm when the salt concentration was 0.5% or more. Further, the transmittance was about 70% at a salt concentration of 0.1%, and the transmittance was significantly lowered as compared with Example 1, and turbidity occurred. This indicates that the high ionic strength aqueous solution in which the powder composition of Example 1 was blended had high stability under a wide range of high ionic strength conditions.

〔添加到食物之試驗〕 [Test added to food]

用以下方法將於實施例1取得之粉末組成物添加到各種食物中以確認該粉末組成物之通用性及有用性。 The powder composition obtained in Example 1 was added to various foods by the following method to confirm the versatility and usefulness of the powder composition.

(實施例8)：添加到牛奶中 (Example 8): added to milk

將1g藉由實施例1取得之粉末組成物混合到99g市售牛奶中，取得了含有約100mg/100g所述脂溶性物質之牛奶。將該牛奶於90℃下進行10分鐘殺菌後，亦未發現該脂溶性物質發生分離，飲用時無不自然之感覺。另外，本品保管30天後完全未有變化，未對原來之性狀造成任何變化。 1 g of the powder composition obtained in Example 1 was mixed into 99 g of commercially available milk to obtain milk containing about 100 mg/100 g of the fat-soluble substance. After the milk was sterilized at 90 ° C for 10 minutes, the fat-soluble substance was not found to be separated, and there was no unnatural feeling when drinking. In addition, there was no change in the product after 30 days of storage, and no change was made to the original trait.

(實施例9)：奶粉飲料 (Example 9): milk powder drink

將1g藉由實施例1取得之粉末組成物混合到10g市售奶粉中，取得了含有約100mg/10g所述脂溶性物質之奶粉。將89g該奶粉溶解於水中，亦未發現該脂溶性物質發生分離，飲用時無不自然之感覺。另外，本品保管30天後完全未有變化，未對原來之性狀造成任何變化。 1 g of the powder composition obtained in Example 1 was mixed into 10 g of commercially available milk powder, and milk powder containing about 100 mg/10 g of the fat-soluble substance was obtained. When 89 g of the milk powder was dissolved in water, the fat-soluble substance was not found to be separated, and there was no unnatural feeling when drinking. In addition, there was no change in the product after 30 days of storage, and no change was made to the original trait.

(實施例10)：果汁飲料 (Example 10): Juice drink

將1g藉由實施例1取得之粉末組成物混合到99g市售果汁飲料中，取得了含有約100mg/100mL之所述脂溶性物質之果汁飲料。將該果汁飲料於90℃下殺菌10分鐘後亦未發現該脂溶性物質所致渾濁，飲用時無不自然之感 覺。另外，本品保管30天後完全未有變化，未對原來之性狀造成任何變化。 1 g of the powder composition obtained in Example 1 was mixed into 99 g of a commercially available juice drink, and a juice drink containing about 100 mg/100 mL of the fat-soluble substance was obtained. After the fruit juice beverage was sterilized at 90 ° C for 10 minutes, no turbidity caused by the fat-soluble substance was observed, and there was no unnatural feeling when drinking. feel. In addition, there was no change in the product after 30 days of storage, and no change was made to the original trait.

(實施例11)：粉末果汁飲料 (Example 11): Powdered fruit juice drink

將1g藉由實施例1取得之粉末組成物混合到14g市售粉末果汁飲料中，取得了含有約100mg/15g之所述脂溶性物質之粉末果汁飲料。將85g該粉末飲料溶解於水中，亦未發現該脂溶性物質所致渾濁，飲用時無不自然之感覺。另外，本品保管30天後完全未有變化，未對原來之性狀造成任何變化。 1 g of the powder composition obtained in Example 1 was mixed into 14 g of a commercially available powdered fruit juice beverage to obtain a powdered fruit juice beverage containing about 100 mg/15 g of the above-mentioned fat-soluble substance. When 85 g of the powdered beverage was dissolved in water, no turbidity caused by the fat-soluble substance was observed, and there was no unnatural feeling when drinking. In addition, there was no change in the product after 30 days of storage, and no change was made to the original trait.

(實施例12)：粉末玉米湯料 (Example 12): Powdered corn soup

將1g藉由實施例1取得之粉末組成物混合到20g市售粉末玉米湯料中，取得了含有約100mg/21g所述脂溶性物質之粉末玉米湯料。將79g該粉末玉米湯料溶解於加溫到95℃中水中，亦未發現該脂溶性物質發生分離，飲用時無不自然之感覺。另外，本品保管30天後完全未有變化，未對原來之性狀造成任何變化。 1 g of the powder composition obtained in Example 1 was mixed into 20 g of a commercially available powdered corn soup to obtain a powdered corn soup containing about 100 mg / 21 g of the fat-soluble substance. 79 g of the powdered corn soup was dissolved in water heated to 95 ° C, and the fat-soluble substance was not found to be separated, and there was no unnatural feeling when drinking. In addition, there was no change in the product after 30 days of storage, and no change was made to the original trait.

(實施例13)：果凍 (Example 13): Jelly

於235g果汁飲料中添加15g藉由實施例1取得之粉末組成物、95g砂糖以及5g粉gelatin，使其沸騰而溶解。將其注入容器中冷卻固化，取得了含有約1500mg/350g所述脂溶性物質之果凍。該果凍完全未見著色班或 輔酶Q10之分離，食用亦無問題。本品保管30天後完全未有變化，未對原來之性狀造成任何變化。 15 g of the powder composition obtained in Example 1, 95 g of granulated sugar, and 5 g of powder gelatin were added to 235 g of the fruit juice drink, and the mixture was boiled and dissolved. This was poured into a container to be cooled and solidified, and a jelly containing about 1500 mg/350 g of the fat-soluble substance was obtained. The jelly has not seen the coloring class at all or Separation of coenzyme Q10, no problem with consumption. This product has not changed completely after 30 days of storage, and has not caused any change to the original trait.

(試驗結果) (test results)

如上所述，本發明品之粉末組成物可添加到水系及粉末狀各種食物中，並且於調製含有該粉末組成物之食物時無任何困難或問題，因此得以確認該粉末組成物對食物之通用性及有用性。 As described above, the powder composition of the present invention can be added to various foods in water and powder form, and there is no difficulty or problem in preparing a food containing the powder composition, so that it is confirmed that the powder composition is common to food. Sex and usefulness.

Claims (6)

一種含脂溶性物質之粉末組成物，其特徵係含(a)脂溶性物質、(b)HLB值為11以上之脂肪酸蔗糖酯、(c)離子性之兩親媒性物質、(d)糖類或者糖醇，且含前述脂溶性物質之分散粒子溶解於水時，以動態光散射法所測定之平均粒徑係10nm以上且150nm以下。 A powder composition containing a fat-soluble substance, characterized by (a) a fat-soluble substance, (b) a fatty acid sucrose ester having an HLB value of 11 or more, (c) an ionic two-parent substance, and (d) a saccharide In the case of a sugar alcohol, and the dispersed particles containing the fat-soluble substance are dissolved in water, the average particle diameter measured by a dynamic light scattering method is 10 nm or more and 150 nm or less. 如請求項1之含脂溶性物質之粉末組成物，其中，脂溶性物質之融點係100℃以下。 A powder composition containing a fat-soluble substance according to claim 1, wherein the fat-soluble substance has a melting point of 100 ° C or less. 如請求項1或2之含脂溶性物質之粉末組成物，其中，離子性之兩親媒性物質係選自高級脂肪酸鹽、皂素、卵磷脂、改質卵磷脂以及***膠中之至少1種。 The powder composition of the fat-soluble substance according to claim 1 or 2, wherein the ionic two-agent substance is at least one selected from the group consisting of higher fatty acid salts, saponin, lecithin, modified lecithin, and gum arabic. Kind. 如請求項1~3中任一項之含脂溶性物質之粉末組成物，其中，糖類或者糖醇係選自單糖類、二糖類、赤蘚糖醇以及山梨糖醇中之至少1種。 The powder composition containing a fat-soluble substance according to any one of claims 1 to 3, wherein the saccharide or the sugar alcohol is at least one selected from the group consisting of monosaccharides, disaccharides, erythritol, and sorbitol. 一種含脂溶性物質之粉末组成物之製造方法，其係含脂溶性物質之分散粒子溶解於水時，以動態光散射法所測定之平均粒徑係10nm以上且150nm以下之含脂溶性物質之粉末组成物之製造方法，其特徵係包括下述(1)~(4)之步驟，且，步驟(1)~(3)之任一步驟係包括添加、混合離子性之兩親媒性物質之過程，且步驟(1)~(3)之任一步驟係包括添加、混合糖類或者糖醇之過程； (1)於水系溶劑中混合HLB值11以上之脂肪酸蔗糖酯以取得水相部份之步驟、(2)融化脂溶性物質以取得油相部份之步驟、(3)將前述油相部份混合至前述水相部份中，於80℃以上之環境下進行乳化以取得預備乳化液之步驟、(4)將前述預備乳化液進行噴霧乾燥以取得前述含脂溶性物質之粉末組成物之步驟。 A method for producing a powder composition containing a fat-soluble substance, wherein the dispersed particles containing a fat-soluble substance are dissolved in water, and the average particle diameter measured by a dynamic light scattering method is a fat-soluble substance having a thickness of 10 nm or more and 150 nm or less. A method for producing a powder composition, comprising the following steps (1) to (4), and wherein any one of the steps (1) to (3) comprises adding and mixing an ionic two-parent substance a process, and any of the steps (1) to (3) includes a process of adding or mixing a sugar or a sugar alcohol; (1) a step of mixing a fatty acid sucrose ester having an HLB value of 11 or more in an aqueous solvent to obtain an aqueous phase portion, (2) a step of melting a fat-soluble substance to obtain an oil phase portion, and (3) a part of the oil phase portion a step of mixing into the aqueous phase portion, emulsification in an environment of 80 ° C or higher to obtain a preliminary emulsion, and (4) spray drying the preliminary emulsion to obtain a powder composition of the fat-soluble substance . 一種飲食物，其特徵係摻合有如請求項1~4中任一項之含脂溶性物質之粉末組成物者。 A food or drink characterized by blending a powder composition containing a fat-soluble substance according to any one of claims 1 to 4.
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