TW201420125A - External preparation for skin - Google Patents
External preparation for skin Download PDFInfo
- Publication number
- TW201420125A TW201420125A TW102140669A TW102140669A TW201420125A TW 201420125 A TW201420125 A TW 201420125A TW 102140669 A TW102140669 A TW 102140669A TW 102140669 A TW102140669 A TW 102140669A TW 201420125 A TW201420125 A TW 201420125A
- Authority
- TW
- Taiwan
- Prior art keywords
- skin
- external preparation
- acid
- poe
- oil
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/26—Aluminium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/27—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q15/00—Anti-perspirants or body deodorants
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Cosmetics (AREA)
- Dispersion Chemistry (AREA)
Abstract
Description
本發明係關於一種皮膚外用劑。進一步詳細說明，係一種調配有擔載有銀之磷酸三鈣粉末、明礬與氧化鋅之皮膚外用劑，並且關於一種於附著於衣服時之耐變色性優異、且制汗效果、防臭效果極為優異之皮膚外用劑。本發明之皮膚外用劑係以防臭為目的而製成防臭用皮膚外用劑、防臭化妝料、制汗化妝料、消臭化妝料等而被較佳地利用。 The present invention relates to a skin external preparation. Further, it is a skin external preparation containing silver tricalcium phosphate powder, alum and zinc oxide, and is excellent in discoloration resistance when attached to clothes, and is excellent in sweating effect and deodorizing effect. Skin external preparation. The external preparation for skin of the present invention is preferably used as a skin external preparation for deodorization, a deodorant cosmetic, a sweating cosmetic, a deodorant cosmetic, and the like for the purpose of deodorization.
專利文獻1中揭示有以銀擔載磷酸鈣作為消臭劑而使用。雖然該消臭劑有可調配制汗劑的記載，但有關具體可調配之制汗劑的一切皆未記載，並且關於調配有制汗劑時之變色亦完全未記載。 Patent Document 1 discloses that silver-supported calcium phosphate is used as a deodorant. Although the deodorant has a description of the adjustable preparation of the sweating agent, nothing about the specifically formulated sweating agent has been described, and the discoloration when the sweating agent is formulated is not described at all.
專利文獻2中揭示有一種消臭用組成物，其記載有若使抗菌性沸石與氧化鋅之粉末組合並使其分散於水中，則基劑會變色而使衣服容易附著髒汙，並且其係利用特定之二羧酸來抑制該變色者。如此，當將抗菌性沸石用於皮膚外用劑時，若與氧化鋅組合則會容易發生變色。 Patent Document 2 discloses a composition for deodorizing, in which it is described that when the antibacterial zeolite and the powder of zinc oxide are combined and dispersed in water, the base material is discolored and the clothes are easily adhered to dirt, and the system is The discoloration is inhibited by using a specific dicarboxylic acid. As described above, when the antibacterial zeolite is used for a skin external preparation, discoloration easily occurs when combined with zinc oxide.
專利文獻3中揭示有一種製劑穩定性優異之防臭化妝料，其若調配組合抗菌性沸石與作為制汗劑而發揮功能之明礬或燒明礬，則可防止基於抗菌性沸石之變色。 Patent Document 3 discloses a deodorant cosmetic which is excellent in stability of a preparation, and when an antibacterial zeolite is combined with an alum or a burnt gel which functions as a sweating agent, discoloration by the antibacterial zeolite can be prevented.
專利文獻1：日本特開平08-126690號公報 Patent Document 1: Japanese Laid-Open Patent Publication No. 08-126690
專利文獻2：日本特開2007-289452號公報 Patent Document 2: Japanese Laid-Open Patent Publication No. 2007-289452
專利文獻3：日本特開2004-307375號公報 Patent Document 3: Japanese Laid-Open Patent Publication No. 2004-307375
本發明人鑒於上述先前技術，針對以特定之銀擔載磷酸三鈣作為消臭劑而使用此點反覆地進行努力研究，結果發現：即便銀擔載磷酸三鈣與氧化鋅組合，雖不會如抗菌性沸石與氧化鋅組合之情形般產生變色，但若與制汗劑之明礬組合，則於附著衣服時變色會發生。此外，發現於使銀擔載磷酸三鈣與明礬組合時所發生之變色，若調配氧化鋅則可抑制該變色，進而完成本發明。 In view of the above-described prior art, the present inventors conducted an intensive study on the use of a specific silver-supported tricalcium phosphate as a deodorant, and found that even if the silver-supported tricalcium phosphate is combined with zinc oxide, it does not When the antibacterial zeolite is combined with zinc oxide, discoloration occurs, but when combined with the alum of the sweating agent, discoloration occurs when the clothes are attached. Further, it has been found that the discoloration which occurs when silver-supported tricalcium phosphate is combined with alum, and the discoloration can be suppressed by blending zinc oxide, and the present invention has been completed.
本發明之目的係提供一種皮膚外用劑，係能以氧化鋅來抑制由組合作為消臭劑而發揮功能之銀擔載磷酸三鈣與制汗劑之明礬而成的皮膚外用劑所致之附著衣服時之變色。 An object of the present invention is to provide an external preparation for skin, which is capable of inhibiting adhesion of an external preparation for skin by a combination of silver-supported tricalcium phosphate and a perspiration of a sweating agent which functions as a deodorant by zinc oxide. The color of the clothes is changed.
即，本發明係提供一種含有銀擔載磷酸三鈣、明礬及氧化鋅之皮膚外用劑。 That is, the present invention provides a skin external preparation containing silver-loaded tricalcium phosphate, alum and zinc oxide.
又，本發明提供上述之皮膚外用劑，其中，相對於皮膚外用劑總量，銀擔載磷酸三鈣粉末之含量為0.5~20質量%，明礬之含量為1~20質量%，氧化鋅之含量為0.05~10質量%。 Furthermore, the present invention provides the above-mentioned skin external preparation, wherein the content of the silver-supported tricalcium phosphate powder is 0.5 to 20% by mass, and the alum content is 1 to 20% by mass, based on the total amount of the external preparation for skin, and zinc oxide The content is 0.05 to 10% by mass.
進而，本發明係提供上述之皮膚外用劑，其係氣溶膠(aerosol)噴霧狀之防臭化妝料。 Further, the present invention provides the above-mentioned skin external preparation which is an aerosol spray-like deodorant cosmetic.
根據本發明係提供一種皮膚外用劑，其能以氧化鋅來抑制由組合銀擔載磷酸三鈣與制汗劑之明礬而成的皮膚外用劑所致之附著衣服時之變色。 According to the present invention, there is provided an external preparation for skin which is capable of suppressing discoloration when attached to clothes caused by a skin external preparation comprising a combination of silver-loaded tricalcium phosphate and a perspiration of a sweating agent with zinc oxide.
又，本發明之皮膚外用劑與使用有銀擔載抗菌性沸石之皮膚外用劑相比，存在有變色少之優點。 Moreover, the external preparation for skin of the present invention has an advantage that the discoloration is small as compared with the external preparation for skin using the silver-loaded antibacterial zeolite.
[銀擔載磷酸三鈣] [Silver-loaded tricalcium phosphate]
本發明所用之銀擔載磷酸三鈣係於磷酸三鈣擔載有銀之白色粉末。本發明中可較佳地利用市售品(Apacider C：Sangi股份有限公司)。 The silver-supported tricalcium phosphate used in the present invention is a white powder in which tricalcium phosphate is supported on silver. A commercially available product (Apacider C: Sangi Co., Ltd.) can be preferably used in the present invention.
銀擔載磷酸三鈣之調配量，相對於皮膚外用劑總量較佳為0.1~20質量%，進而較佳為1~10質量%。 The amount of the silver-supported tricalcium phosphate is preferably 0.1 to 20% by mass, and more preferably 1 to 10% by mass based on the total amount of the external preparation for skin.
調配量若未達0.1質量%則有無法充分發揮作為消臭劑之功能的情形。又，若超過20質量%則將本發明之皮膚外用劑塗佈於皮膚時會有泛白過於明顯之情形。 If the amount is less than 0.1% by mass, the function as a deodorant may not be sufficiently exhibited. In addition, when it exceeds 20 mass%, when the external preparation for skin of the present invention is applied to the skin, the whitening is too obvious.
[明礬] [alum]
本發明所用之明礬係發揮作為制汗劑之功能的必須成分。本發明中使用市售品之粉末。本發明中所使用之明礬亦可使用燒明礬。市售品中較佳為使用例如TIES S150、TIES S100、TIES K150、TIES K20(大明化學工業股份有限公司)等。 The alum used in the present invention exerts an essential component as a function of a sweating agent. A powder of a commercially available product is used in the present invention. The alum used in the present invention may also be used. Among the commercially available products, for example, TIES S150, TIES S100, TIES K150, TIES K20 (Da Ming Chemical Industry Co., Ltd.) and the like are preferably used.
明礬之調配量相對於皮膚外用劑總量較佳為1~20質量 %，進而較佳為2~10質量%。 The amount of alum is preferably 1 to 20 by mass relative to the total amount of external preparation for skin. %, further preferably 2 to 10% by mass.
調配量若未達1質量%則有無法充分發揮作為制汗劑之功能的情形。又，若超過20質量%則將本發明之皮膚外用劑塗佈於皮膚時會有泛白過於明顯之情形。 If the amount is less than 1% by mass, the function as a sweating agent may not be sufficiently exhibited. In addition, when it exceeds 20 mass%, when the external preparation for skin of the present invention is applied to the skin, the whitening is too obvious.
將明礬調配於氣溶膠噴霧時，明礬之平均粒徑較佳為0.01~50μm之微粒子粉末。再者，平均粒徑係利用由穿透型電子顯微鏡相片之圖像解析所得之個數平均徑等的通常方法來測定。 When the alum is formulated in an aerosol spray, the average particle diameter of the alum is preferably 0.01 to 50 μm. Further, the average particle diameter is measured by a usual method such as the number average diameter obtained by image analysis of a transmission electron microscope photograph.
[氧化鋅] [Zinc oxide]
本發明之皮膚外用劑中，若使銀擔載磷酸三鈣與明礬組合則本發明人發現於皮膚外用劑附著衣服時變色會發生，並且發現該變色藉由調配氧化鋅而抑制。 In the external preparation for skin of the present invention, when the silver-supported tricalcium phosphate is combined with alum, the present inventors have found that discoloration occurs when the external preparation for skin adheres to the clothes, and it is found that the discoloration is suppressed by the preparation of zinc oxide.
即，本發明中氧化鋅係發揮附著衣服時作為變色抑制劑之功能的必須成分。 That is, in the present invention, the zinc oxide is an essential component of the function as a coloring inhibitor when the clothes are attached.
本發明中氧化鋅係以粉末進行調配。並未限定氧化鋅之製法及粒徑。 In the present invention, zinc oxide is formulated in a powder. The method and particle size of zinc oxide are not limited.
使用抗菌性沸石之消臭組成物，若於水系組成物中特別是調配氧化鋅粉末則變色容易發生，但使用銀擔載磷酸三鈣之消臭用組成物，即便於水系組成物中調配氧化鋅粉末，亦不會如抗菌性沸石般地發生變色。不僅如此，氧化鋅若與銀擔載磷酸鈣及明礬組合，則會發揮本發明所屬技術領域者所無法預期的抑制於附著衣服時所發生之變色的顯著效果。 When the deodorizing composition of the antibacterial zeolite is used, discoloration is likely to occur if the zinc oxide powder is blended in the aqueous composition, but the deodorizing composition containing the tricalcium phosphate is used to prepare the oxidation in the aqueous composition. Zinc powder does not discolor like an antimicrobial zeolite. Moreover, when zinc oxide is combined with silver-supported calcium phosphate and alum, it exhibits a remarkable effect of suppressing discoloration which occurs when clothes are attached, which cannot be expected by those skilled in the art.
氧化鋅之調配量相對於皮膚外用劑總量較佳為0.05~10質量%，進而較佳為0.1~5質量%。 The amount of the zinc oxide to be added is preferably 0.05 to 10% by mass, and more preferably 0.1 to 5% by mass based on the total amount of the external preparation for skin.
配合量若未達0.05質量%則會有無法充分發揮上述之變色抑制效果的 情形。又，若超過10質量%則會有於塗佈時泛白過於明顯之情形。 If the amount is less than 0.05% by mass, the above-described discoloration suppressing effect may not be sufficiently exhibited. situation. Moreover, if it exceeds 10 mass%, there may be a case where the whitening is too obvious at the time of coating.
本發明之皮膚外用劑中，除上述必須成分以外視需要適當調配通常皮膚外用劑所用之其他成分，例如如下所例示之成分的一種或二種以上，可視目的之劑型利用常法來製造。作為較佳之製品，較佳為作為防臭用皮膚外用劑之防臭化妝料、制汗化妝料。 In the external preparation for skin of the present invention, other components used for the external preparation for external skin, such as one or two or more of the components exemplified below, may be appropriately prepared in addition to the above-mentioned essential components, and the dosage form may be produced by a usual method. As a preferable product, a deodorant cosmetic and a sweat-absorbing cosmetic which are external preparations for deodorizing skin are preferable.
油分例如可列舉山茶油、澳洲胡桃油、玉米油、橄欖油、菜籽油、蛋黃油、芝麻油、核仁油、小麥胚芽油、山茶花油、亞麻仁油、紅花油、棉籽油、月見草油、大豆油、花生油、茶籽油、極油、米糠油、荷荷芭油、胚芽油、三甘油、三辛酸甘油酯、三異棕櫚酸甘油酯等液態油脂；可可脂、椰子油、硬化椰子油、棕櫚油、棕櫚仁油、木蠟仁油、氫化油、木蠟、氫化蓖麻油等固態油脂；蜂蠟、堪地里拉蠟、巴西蠟、羊毛脂等蠟類；液體石蠟、地蠟、角鯊烯、石蠟、純地蠟、鯊烷、凡士林、微晶蠟等烴油；肉豆蔻酸異丙酯、辛酸鯨蠟酯、肉豆蔻酸辛基十二基酯、棕櫚酸異丙酯、月桂酸己酯、肉豆蔻酸肉豆蔻酯、二甲基辛酸己基癸酯、乳酸鯨蠟酯、乳酸肉豆蔻酯、硬脂酸異鯨蠟酯、異硬脂酸異鯨蠟酯、膽固醇12-羥基硬脂酸酯、二-2-乙基己酸乙二醇酯、二新戊四醇脂肪酸酯、二癸酸新戊二醇酯、蘋果酸二異硬脂酯、二-2-庚基十一酸甘油酯、三羥甲基丙烷三-2-乙基己酸酯、三羥甲基丙烷三異硬酯酸酯、新戊四醇四-2-乙基己酸酯、三-2-乙基己酸甘油酯、三羥甲基丙烷三異硬酯酸酯、2-乙基己酸鯨蠟酯、棕櫚 酸-2-乙基己酯、三肉豆蔻酸甘油酯、三-2-庚基十一酸甘油酯、棕櫚酸-2-庚基十一烷基酯、己二酸二異丙酯、N-月桂醯基-L-麩胺酸-2-辛基十二基酯、己二酸二-2-庚基十一基酯、癸二酸二-2-乙基己酯、肉豆蔻-2-己基癸酯、己二酸-2-己基癸酯、癸二酸二異丙酯、琥珀酸-2-乙基己酯等酯油；月桂酸、肉豆蔻酸、棕櫚酸、硬脂酸、山崳酸、油酸、12-羥基硬酯酸、十一烯酸、羊毛脂肪酸、異硬脂酸、亞麻油酸、次亞麻油酸、二十碳五烯酸等高級脂肪酸；月桂醇、鯨蠟醇、硬脂醇、山崳醇、肉豆蔻醇、油醇、鯨蠟硬脂醇(cetostearyl alcohol)、單硬脂基甘油醚(鯊肝醇)、2-癸基十四醇、羊毛醇、膽固醇、植固醇、己基十二醇、異硬脂醇、辛基十二醇等直鏈或支鏈高級醇；二甲基聚矽氧烷、甲基苯基聚矽氧烷等聚矽氧油等。 Examples of the oil component include camellia oil, Australian walnut oil, corn oil, olive oil, rapeseed oil, egg butter, sesame oil, nucleolus oil, wheat germ oil, camellia oil, linseed oil, safflower oil, cottonseed oil, evening primrose oil, Liquid fats such as soybean oil, peanut oil, tea seed oil, extreme oil, rice bran oil, jojoba oil, germ oil, triglycerin, tricaprylin, triisopalmitate; cocoa butter, coconut oil, hardened coconut oil , palm oil, palm kernel oil, wood wax oil, hydrogenated oil, wood wax, hydrogenated castor oil and other solid oils; beeswax, candid wax, Brazilian wax, lanolin and other waxes; liquid paraffin, ground wax, horn shark Hydrocarbon oils such as alkenyl, paraffin, pure ceresin, squalane, petrolatum, microcrystalline wax; isopropyl myristate, cetyl octanoate, octyldodecyl myristate, isopropyl palmitate, lauric acid Ester, myristyl myristate, hexyl dimethyl octanoate, cetyl lactate, myristyl lactate, isocetyl stearate, isocetyl isostearate, cholesterol 12-hydroxystearate Acid ester, ethylene glycol di-2-ethylhexanoate, two new Tetraol fatty acid ester, neopentyl glycol dicaprate, diisostearyl malate, di-2-heptyldecanoic acid glyceride, trimethylolpropane tri-2-ethylhexanoate, Trimethylolpropane triisostearate, pentaerythritol tetra-2-ethylhexanoate, tris-2-ethylhexanoate, trimethylolpropane triisostearate, 2 -ethylhexanoate cetyl ester, palm Acid-2-ethylhexyl ester, trimyristyl glycerate, tris-2-heptyldecanoate, palmitic acid 2-heptyl undecyl ester, diisopropyl adipate, N -Lauryl-L-glutamic acid-2-octyldodecyl ester, di-2-heptylundecyl adipate, di-2-ethylhexyl sebacate, nutmeg-2 - ester oils such as hexyl decyl phthalate, 2-hexyl decyl adipate, diisopropyl sebacate, 2-ethylhexyl succinate; lauric acid, myristic acid, palmitic acid, stearic acid, Higher fatty acids such as behenic acid, oleic acid, 12-hydroxystearic acid, undecylenic acid, wool fatty acid, isostearic acid, linoleic acid, linoleic acid, eicosapentaenoic acid; lauryl alcohol, whale Wax alcohol, stearyl alcohol, behenyl alcohol, myristyl alcohol, oleyl alcohol, cetostearyl alcohol, monostearyl glyceryl ether (shark liver alcohol), 2-mercaptotetradecyl alcohol, lanolin alcohol , cholesterol, phytol, hexyldodecanol, isostearyl alcohol, octyldodecanol, and other linear or branched higher alcohols; dimethyl polyoxane, methyl phenyl polyoxyalkylene, etc. Oxygen oil, etc.
界面活性劑例如可列舉如下：脂肪酸、烷基醚硫酸酯鹽、月桂醯基肌胺酸鈉等N-醯基肌胺酸、N-肉豆蔻醯基-N-甲基牛磺酸鈉、椰子油脂肪酸甲基牛磺酸鈉等高級脂肪酸醯胺磺酸鹽、單月桂醯基單乙醇醯胺POE磺基琥珀酸鈉、月桂基聚丙二醇磺基琥珀酸鈉等磺基琥珀酸鹽、烷基苯磺酸鹽、N-醯基麩胺酸鹽、高級脂肪酸酯硫酸酯鹽、土耳其紅油(turkey red oil)等硫酸化油、POE-烷基醚羧酸鹽、POE-烷基烯丙醚羧酸鹽、高級脂肪酸酯磺酸鹽、二級醇硫酸酯鹽、高級脂肪酸烷醇醯胺硫酸酯鹽、月桂醯基單乙醇醯胺琥珀酸鈉等陰離子系界面活性劑；硬脂基三甲基氯化銨等烷基三甲基銨鹽、二硬脂基二甲基氯化銨鹽等二烷基二甲基銨鹽、十六烷基氯化吡啶(cetylpyridinium chloride)等烷基 吡啶鹽、苄基氯化銨等陽離子系界面活性劑；2-椰油醯基-2-氫氧化咪唑啉鎓-1-羧乙氧基二鈉鹽等咪唑啉系兩性界面活性劑；醯胺甜菜鹼、磺基甜菜鹼等甜菜鹼系界面活性劑等兩性界面活性劑；山梨糖醇酐單油酸酯、山梨糖醇酐單異硬脂酸酯、山梨糖醇酐單月桂酸酯、山梨糖醇酐三油酸酯等山梨糖醇酐脂肪酸酯類；單棉籽油脂肪酸甘油酯、單硬脂酸甘油酯、倍半油酸甘油酯、蘋果酸單硬脂酸甘油酯等聚甘油脂肪酸甘油酯類；單丙二醇硬脂酸酯等丙二醇酯肪酸酯；氫化蓖麻油衍生物，甘油烷基醚，POE-甲基聚矽氧烷共聚物等親油性非離子性界面活性劑；POE-山梨糖醇酐單油酸酯、POE-山梨糖醇酐單硬脂酸酯等POE山梨糖醇酐脂肪酸酯類；POE-山梨糖醇單月桂酸酯、POE-山梨糖醇單油酸酯、POE-山梨糖醇單硬脂酸酯等POE-山梨糖脂肪酸酯類；POE-甘油單油酸酯、POE-甘油二硬脂酸酯等POE-甘油脂肪酸酯類；POE-二硬脂酸酯之POE-脂肪酸酯類；POE-月桂醚、POE-二氫膽固醇醚等POE-烷基醚，POE-辛基苯基醚、POE-壬基苯基醚等POE-烷基苯基醚類；POE-聚氧丙烯(以下稱為POP)-單丁醚、POE-POP-鯨蠟醚、POE-POP-甘油醚等POE-POP-烷基醚類；POE-氫化蓖麻油、POE-氫化蓖麻油單異硬脂酸酯、POE-氫化蓖麻油 順丁烯二酸酯等POE氫化蓖麻油衍生物；椰子油脂肪酸二乙醇醯胺、脂肪酸異丙醇醯胺等烷醇醯胺；POE-丙二醇脂肪酸酯，POE脂肪酸醯胺，POE-烷基胺，POE-脂肪酸醯胺，蔗糖脂肪酸酯，烷基乙氧基二甲基氧化胺等親水性非離子性界面活性劑等。 Examples of the surfactant include the following: a fatty acid, an alkyl ether sulfate, a sodium lauric acid, and other N-mercaptocreatine, N-myristyl-N-methyl taurate, and coconut. High-grade fatty acid decyl sulfonate such as oil fatty acid methyl taurate, monolauroyl monoethanol amide, POE sulfosuccinate, sodium lauryl propylene sulfosuccinate, sulfosuccinate, alkyl Sulfated oil such as besylate, N-mercapto glutamate, higher fatty acid ester sulfate, turkey red oil, POE-alkyl ether carboxylate, POE-alkyl ally Anionic surfactant such as ether carboxylate, higher fatty acid ester sulfonate, secondary alcohol sulfate, higher fatty acid alkanolamine sulfate, lauryl mercapto monoethanol guanamine succinate; stearyl An alkyl group such as an alkyltrimethylammonium salt such as trimethylammonium chloride or a dialkyldimethylammonium salt such as distearyl dimethylammonium chloride or an alkyl group such as cetylpyridinium chloride. a cationic surfactant such as a pyridinium salt or a benzyl ammonium chloride; an imidazoline-based amphoteric surfactant such as 2-cocoyl-2-hydroiodazolidinium-1-carboxyethoxy disodium salt; An amphoteric surfactant such as a betaine-based surfactant such as betaine or sulfobetaine; sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, Yamanashi Sorbitol fatty acid esters such as sugar anhydride trioleate; polyglycerol fatty acid glycerol such as single cottonseed oil fatty acid glyceride, glyceryl monostearate, glyceryl sesquioleate, glyceryl monostearate Ester; propylene glycol fatty acid ester such as monopropylene glycol stearate; hydrogenated castor oil derivative, glycerin alkyl ether, POE-methyl polyoxyalkylene copolymer and other lipophilic nonionic surfactant; POE-sorbent POE sorbitan fatty acid esters such as sugar anhydride monooleate, POE-sorbitan monostearate; POE-sorbitol monolaurate, POE-sorbitol monooleate, POE - POE-sorbitan fatty acid esters such as sorbitol monostearate; POE-glycerol monooleate, POE-gan POE-glycerol fatty acid esters such as distearate; POE-fatty acid esters of POE-distearate; POE-alkyl ether such as POE-lauric ether, POE-dihydrocholesterol ether, POE-octylbenzene POE-alkylphenyl ethers such as phenyl ether, POE-nonylphenyl ether; POE-polyoxypropylene (hereinafter referred to as POP)-monobutyl ether, POE-POP-cetyl ether, POE-POP-glyceryl ether POE-POP-alkyl ethers; POE-hydrogenated castor oil, POE-hydrogenated castor oil monoisostearate, POE-hydrogenated castor oil POE hydrogenated castor oil derivatives such as maleic acid ester; coconut oil fatty acid diethanol decylamine, fatty acid isopropyl alcohol decylamine, etc.; POE-propylene glycol fatty acid ester, POE fatty acid decylamine, POE-alkyl A hydrophilic nonionic surfactant such as an amine, a POE-fatty acid decylamine, a sucrose fatty acid ester or an alkyl ethoxy dimethyl amine oxide.
粉末例如可列舉雲母、滑石、高嶺土、絹雲母(sericite)、白雲母、金雲母、合成雲母、紅雲母、黑雲母、鋰雲母、合成雲母、碳酸鈣、碳酸鎂、矽酸酐(二氧化矽)、矽酸鋁、矽酸鋇、矽酸鈣、矽酸鎂、系酸鍶、氧化鋁、硫酸鋇、紅丹、氧化鐵黃、氧化鐵黑、氧化鈷、群青、普魯士藍(prussian blue)、氧化鈦、氧化錫、鈦雲母(被覆有氧化鈦之雲母)、魚鱗箔、氫氯化鉍、氮化硼、紅色228號、紅色226號、藍色404號、聚乙烯粉末、聚甲基丙烯酸甲酯粉末、聚醯胺樹脂粉末(尼龍粉末)、纖維素粉末、有機聚矽氧烷彈性體、鋁粉末、銅粉末等。 Examples of the powder include mica, talc, kaolin, sericite, muscovite, phlogopite, synthetic mica, red mica, biotite, lithium mica, synthetic mica, calcium carbonate, magnesium carbonate, and phthalic anhydride (cerium oxide). , aluminum citrate, barium strontium citrate, calcium citrate, magnesium citrate, barium strontium, alumina, barium sulfate, red dan, iron oxide yellow, iron oxide black, cobalt oxide, ultramarine blue, prussian blue, Titanium oxide, tin oxide, titanium mica (titanium coated with titanium oxide), fish scale foil, barium hydrochloride, boron nitride, red 228, red 226, blue 404, polyethylene powder, polymethacrylic acid Methyl ester powder, polyamide resin powder (nylon powder), cellulose powder, organopolysiloxane elastomer, aluminum powder, copper powder, and the like.
醇類例如可列舉乙醇、丙醇、異丙醇等低級醇，膽固醇、固醇、羊毛固醇等低級醇。 Examples of the alcohols include lower alcohols such as ethanol, propanol and isopropanol, and lower alcohols such as cholesterol, sterol and lanosterol.
增黏劑例如可列舉如下：***樹膠、黃蓍膠、半乳聚糖、刺槐膠(carob gum)、瓜爾膠、角叉菜膠、果膠、寒天、澱粉(玉米、小麥、馬鈴薯、米)等植物系高分子，聚葡萄糖、聚三葡萄糖等微生物系高分子，羧甲基澱粉、甲基羥丙基澱粉、等澱粉系高分子膠原蛋白、甲基纖維素、乙基纖維素、羥乙基纖維素、纖維素硫酸鈉(cellulose sulfate sodium salt)、羥丙基纖維素、羧甲基纖維素、結晶纖維素 等纖維素系高分子，海藻酸鈉、海藻酸丙二醇酯等海藻酸系高分子，聚乙烯甲基醚、羧基乙烯聚合物等乙烯系高分子，POE系高分子，POE聚氧丙基共聚物系高分子，聚丙烯酸鈉、聚丙烯酸醯胺等丙烯酸系高分子，膨潤土、矽酸鋁鎂(magnesium aluminum silicate)、合成鋰皂石(laponite)、鋰膨潤石、矽酸酐等無機系水溶性高分子等。 Examples of the tackifier include the following: gum arabic, tragacanth, galactan, carab gum, guar gum, carrageenan, pectin, cold weather, starch (corn, wheat, potato, rice). Plant-based polymers, microbial polymers such as polydextrose and polytriglucose, carboxymethyl starch, methyl hydroxypropyl starch, starch-based polymer collagen, methyl cellulose, ethyl cellulose, and hydroxy Ethyl cellulose, cellulose sulfate sodium salt, hydroxypropyl cellulose, carboxymethyl cellulose, crystalline cellulose Cellulose-based polymer, alginate polymer such as sodium alginate or propylene glycol alginate, vinyl polymer such as polyvinyl methyl ether or carboxyvinyl polymer, POE polymer, POE polyoxypropyl copolymer It is an acrylic polymer such as a polymer, sodium polyacrylate or polyacrylamide, and inorganic water such as bentonite, magnesium aluminum silicate, laponite, lithium bentonite, and phthalic anhydride. Molecules, etc.
螯合劑例如可列舉日本扁柏油(hinokitiol)、沒食子酸、單寧酸、咖啡酸、伸乙二胺四乙酸、伸乙二醇二胺四乙酸、二伸乙三胺五乙酸、植酸、多磷酸、偏磷酸、該等之類似物、以及該等之鹼金屬鹽類及羧酸酯類等。 Examples of the chelating agent include hinokitiol, gallic acid, tannic acid, caffeic acid, ethylenediaminetetraacetic acid, ethylene glycol diaminetetraacetic acid, diethylenetriamine pentaacetic acid, and phytic acid. , polyphosphoric acid, metaphosphoric acid, such analogs, and such alkali metal salts and carboxylic acid esters.
紫外線吸收劑例如可列舉：辛基-對甲氧基桂皮酸酯、4-第三丁基-4'-甲氧基二苯甲醯基甲烷、氰雙苯丙烯酸辛酯(octocrylene)等。 Examples of the ultraviolet absorber include octyl-p-methoxycinnamate, 4-t-butyl-4'-methoxybenshydrylmethane, and octocrylene.
保濕劑例如可列舉：聚乙二醇、丙二醇、二丙二醇、1,3-丁二醇、甘油、二甘油、木糖醇、麥芽糖醇、麥芽糖、右旋甘露醇(D-mannitol)、果糖、玻尿酸鈉(hyaluronate sodium)、葡萄胺糖、環糊精等。 Examples of the humectant include polyethylene glycol, propylene glycol, dipropylene glycol, 1,3-butylene glycol, glycerin, diglycerin, xylitol, maltitol, maltose, D-mannitol, and fructose. Hyaluronate sodium, glucosamine, cyclodextrin, etc.
藥效成分例如可列舉：視黃醇(retinol)、棕櫚酸視黃醇酯(retinol palmitate)、鹽酸吡哆醇(pyridoxine hydrochloride)、菸鹼醯胺、dl-α-菸鹼酸生育酚酯、抗壞血酸磷酸鎂、維生素D2、dl-α-生育酚、泛酸、生物素等維生素類； 甘菊藍(azulene)、甘草酸苷(glycyrrhizin)等抗炎劑；傳明酸、4-甲氧基水楊酸鉀等美白劑；丹寧酸等收斂劑；L-薄荷腦、樟腦等清涼劑；防腐劑可列舉：對羥苯甲酸酯(對羥苯甲酸甲酯、對羥基苯甲酸乙酯、對羥基苯甲酸丙酯等)、山梨酸、羥基氯苯胺(benzalkonium chloride)、氯化氯己定(chlorhexidine chloride)、三氯均二苯脲(trichlorocarbanilide)、感光素、2-苯氧乙醇等。 Examples of the medicinal ingredient include retinol, retinol palmitate, pyridoxine hydrochloride, nicotinamide, dl-α-nicotinic acid tocopheryl ester, Ascorbyl magnesium phosphate, vitamin D 2 , dl-α-tocopherol, pantothenic acid, biotin and other vitamins; azulene, glycyrrhizin and other anti-inflammatory agents; tranexamic acid, 4-methoxy A whitening agent such as potassium salicylate; an astringent such as tannic acid; a cooling agent such as L-menthol and camphor; and a preservative: a paraben (methyl paraben, ethyl p-hydroxybenzoate) , propyl paraben, etc.), sorbic acid, benzalkonium chloride, chlorhexidine chloride, trichlorocarbanilide, photoreceptor, 2-phenoxyethanol, etc. .
其它調配成分可列舉：2-胺基-2-甲基-1-丙醇、2--胺基-2-甲基-1,3-丙二醇、氫氧化鉀、三乙醇胺、碳酸鈉等中和劑；乳酸、檸檬酸、乙醇酸、琥珀酸、酒石酸、蘋果酸、碳酸氫鈉、碳酸氫銨等pH值調整劑；抗壞血酸、α-生育酚、類胡蘿蔔素等抗氧化劑。 Other compounding ingredients include neutralization of 2-amino-2-methyl-1-propanol, 2-aminomethyl-2-methyl-1,3-propanediol, potassium hydroxide, triethanolamine, sodium carbonate, and the like. Agent; pH adjuster such as lactic acid, citric acid, glycolic acid, succinic acid, tartaric acid, malic acid, sodium hydrogencarbonate or ammonium hydrogencarbonate; antioxidants such as ascorbic acid, α-tocopherol and carotenoid.
本發明之皮膚外用劑之製品型態並無特別限制。例如可列舉氣溶膠噴霧型、滾塗型roll-on)、粉末型及壓縮粉末型(pressed powder，成型粉末)、條型等。 The product form of the external preparation for skin of the present invention is not particularly limited. For example, an aerosol spray type, a roll-on type, a powder type, a pressed powder type, a strip type, etc. are mentioned.
本發明中，特別是氣溶膠噴霧型為佳。為氣溶膠噴霧型之情況時，利用常用方法將本發明之皮膚外用劑與液化氣體等噴霧劑或乙醇一起填充到氣溶膠罐中而製造。此外，於乙醇中明礬係分散性差，但藉由調配銀擔載磷酸三鈣而於本發明獲得使乙醇中明礬之分散性提高的新穎發現。 In the present invention, in particular, an aerosol spray type is preferred. In the case of the aerosol spray type, the external preparation for skin of the present invention is produced by filling a spray agent such as a liquefied gas or ethanol into an aerosol can by a usual method. Further, in the case of ethanol, the alum is poorly dispersible, but the present invention obtains a novel finding that the dispersibility of alum in ethanol is improved by blending silver-supported tricalcium phosphate.
實施例 Example
接著以實施例進一步具體說明本發明。本發明並非以其來 限定者。調配量只要無特別限定則為對總量之質量%。 The invention will now be further described in detail by way of examples. The invention is not based on it Qualifier. The blending amount is the mass % of the total amount unless otherwise specified.
〔實施例1~9、比較例1〕 [Examples 1 to 9 and Comparative Example 1]
〔除臭噴霧〕 [Deodorant Spray]
以表1所示之實施例及比較例之組成調製成粉末乳液型之除臭乳液中，將其填充至50ml之玻璃管，以下述方法評價粉末之再分散性、沉降速度。又，以原液(粉末乳液)：LPG氣體=約2：8來填充該除臭乳液至氣溶膠容器中，並且以下述方法來評價附著於衣服時之變色。 The deodorant emulsion of the powder emulsion type was prepared in the composition of the examples and the comparative examples shown in Table 1, and was filled in a glass tube of 50 ml, and the redispersibility and sedimentation rate of the powder were evaluated by the following methods. Further, the deodorant emulsion was filled into an aerosol container with a stock solution (powder emulsion): LPG gas = about 2:8, and the discoloration when attached to clothes was evaluated by the following method.
<粉末之再分散性> <Dispersibility of powder>
填充至50ml玻璃管後，靜置1小時使粉末沉降，之後搖晃玻璃管並攪拌，卻任其再分散性。 After filling into a 50 ml glass tube, the powder was allowed to stand for 1 hour to allow the powder to settle, and then the glass tube was shaken and stirred while allowing it to be redispersible.
<判定> <decision>
○：在5次以內之搖晃即再分散。 ○: Redispersed within 5 times.
×：即便搖晃20次以上亦未再分散。 ×: Even if it was shaken 20 times or more, it was not dispersed again.
<粉末之沉降速度> <Pilling speed of powder>
填充至50ml玻璃管後，均勻攪拌、靜置後，利用目視觀察粉末之沉降速度。 After filling into a 50 ml glass tube, the mixture was uniformly stirred and allowed to stand, and the sedimentation speed of the powder was visually observed.
<判定> <decision>
○：20秒以上仍未見到上層之分離。 ○: No separation of the upper layer was observed for more than 20 seconds.
×：10秒以內即確認到上層之分離。 ×: The separation of the upper layer was confirmed within 10 seconds.
<變色之確認方法> <Confirmation method of discoloration>
於腋下將除臭噴霧塗佈3秒鐘，穿著白色衣服並經過8小時日常作息，之後利用目視觀察該衣服放置室內燈光下2小時之情況下的變色。 The deodorant spray was applied under the arm for 3 seconds, dressed in white clothes and subjected to daily work for 8 hours, and then visually observed the discoloration of the clothes under the condition of room light for 2 hours.
<判定> <decision>
○：未確認到變色。 ○: No discoloration was confirmed.
×：確認到變色。 ×: Color change was confirmed.
由「表1」之結果可知組合有銀擔載磷酸三鈣與明礬之情形時，附著於衣服時之變色會產生(比較例1、比較例2)。然而，由實施例1~實施例11可知若調配氧化鋅則可防止該變色。 From the results of "Table 1", it was found that when silver-supported tricalcium phosphate and alum were combined, discoloration occurred when adhering to clothes (Comparative Example 1 and Comparative Example 2). However, it is understood from Examples 1 to 11 that discoloration can be prevented by disposing zinc oxide.
又，可知於乙醇中有明礬之再分散性差的問題(比較例2)，但藉由 調配銀載持磷酸三鈣而使再分散性良好而解決該問題。 Moreover, it is known that there is a problem that the redispersibility of alum is poor in ethanol (Comparative Example 2), but This problem is solved by blending silver with tricalcium phosphate to make the redispersibility good.
進而，可知若調配5質量%以上水則粉末之沉降速度會變快(實施例11)。若考慮製造時填充至氣溶膠容器的步驟，則較佳為再分散性優異、沉降速度慢之粉末乳液。因此，於本發明中，相對於作為皮膚外用劑之粉末乳液總量進而較佳為不含5質量%以上水。 Further, it is understood that when the water is blended in an amount of 5 mass% or more, the sedimentation speed of the powder is increased (Example 11). In consideration of the step of filling into the aerosol container at the time of production, a powder emulsion excellent in redispersibility and slow in sedimentation speed is preferred. Therefore, in the present invention, it is preferable that the total amount of the powder emulsion as the external preparation for skin is not more than 5% by mass of water.
混合上述成分製成除臭原液，並填充至噴霧罐，之後以原液：LPG成為10：90之方式封入LPG。 The above components were mixed to prepare a deodorant stock solution, and the mixture was filled in a spray can, and then the LPG was sealed in such a manner that the original liquid: LPG was 10:90.
混合上述成分製成除臭原液，並填充至噴霧罐，之後以原液：LPG成為10：90之方式封入LPG。 The above components were mixed to prepare a deodorant stock solution, and the mixture was filled in a spray can, and then the LPG was sealed in such a manner that the original liquid: LPG was 10:90.
混合上述成分並填充至寶特瓶容器或噴霧容器，以獲得乳液狀組成 物。 Mix the above ingredients and fill them into a PET bottle container or spray container to obtain an emulsion-like composition Things.
加熱混合上述成分並填充至條狀容器，冷卻至室溫而獲得條狀組成物。 The above ingredients were mixed by heating and filled in a strip-shaped container, and cooled to room temperature to obtain a strip-like composition.
利用混合機混合上述成分而獲得粉末狀組成物。 The above components were mixed by a mixer to obtain a powdery composition.
根據本發明可提供一種皮膚外用劑，其係能以氧化鋅來抑制由組合作為消臭劑而發揮功能之銀擔載磷酸三鈣與制汗劑之明礬而成 的皮膚外用劑所致之附著衣服時之變色。 According to the present invention, it is possible to provide an external preparation for skin which is capable of suppressing alum containing a calcium-loaded tricalcium phosphate and a sweating agent which functions as a deodorant in combination with zinc oxide. The skin discoloration caused by the external application of the skin.
本發明之皮膚外用劑，其制汗效果及防臭效果優異，並且作為制汗化妝料、防臭化妝料極為有用。 The skin external preparation of the present invention is excellent in sweat-making effect and deodorant effect, and is extremely useful as a sweat-absorbing cosmetic or a deodorant cosmetic.
Claims (3)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2012259331A JP5525027B2 (en) | 2012-11-28 | 2012-11-28 | Topical skin preparation |
| JPJP2012-259331 | 2012-11-28 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW201420125A true TW201420125A (en) | 2014-06-01 |
| TWI634906B TWI634906B (en) | 2018-09-11 |
Family
ID=50827741
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW102140669A TWI634906B (en) | 2012-11-28 | 2013-11-08 | Skin external preparation |
Country Status (7)
| Country | Link |
|---|---|
| JP (1) | JP5525027B2 (en) |
| KR (1) | KR101601618B1 (en) |
| CN (1) | CN104968322B (en) |
| HK (1) | HK1211480A1 (en) |
| SG (1) | SG11201504134SA (en) |
| TW (1) | TWI634906B (en) |
| WO (1) | WO2014084099A1 (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6681760B2 (en) * | 2015-03-24 | 2020-04-15 | 株式会社コーセー | Antiperspirant composition, aerosol formulation |
| JP6577322B2 (en) * | 2015-10-07 | 2019-09-18 | エア・ウォーター・ゾル株式会社 | Aerosol preparation containing ethanol |
| JP6644416B2 (en) * | 2016-01-05 | 2020-02-12 | 株式会社マンダム | Composition for suppressing body odor |
| JP7311416B2 (en) * | 2017-08-31 | 2023-07-19 | 株式会社 資生堂 | Multi-layer powder cosmetics |
| CN107595663A (en) * | 2017-11-09 | 2018-01-19 | 武汉励合生物医药科技有限公司 | A kind of high-temperature stability skin preparations for extenal use |
| KR20210022519A (en) * | 2018-06-22 | 2021-03-03 | 라이온 가부시키가이샤 | Powder deodorant composition, powder deodorant composition product, and deodorant method |
| CN108888556B (en) * | 2018-07-31 | 2021-06-04 | 北京东方淼森生物科技有限公司 | Noni active carrier composition, preparation method and application |
| JP7486287B2 (en) * | 2019-04-26 | 2024-05-17 | 小林製薬株式会社 | Deodorant powder composition |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH08126690A (en) * | 1994-10-28 | 1996-05-21 | Sangi Co Ltd | Deodorant |
| KR100529284B1 (en) * | 2000-10-06 | 2005-11-17 | 가부시키가이샤 상기 | Antibacterial resin |
| JP2003286146A (en) * | 2002-03-29 | 2003-10-07 | Toagosei Co Ltd | Antiperspirant and deodorant cosmetic |
| JP4274354B2 (en) | 2003-04-04 | 2009-06-03 | 株式会社資生堂 | Topical skin preparation |
| JP4951785B2 (en) * | 2004-04-13 | 2012-06-13 | 鈴木油脂工業株式会社 | Antibacterial fine particles, process for producing the same, and cosmetics or fungicides containing the antibacterial fine particles |
| JP4721436B2 (en) | 2006-04-26 | 2011-07-13 | 株式会社 資生堂 | Deodorant composition |
| JP2008150330A (en) * | 2006-12-19 | 2008-07-03 | Pola Chem Ind Inc | Water-in-oil emulsion type skin care preparation |
| JP5302523B2 (en) * | 2007-08-20 | 2013-10-02 | 株式会社 資生堂 | Topical skin preparation |
| CN102239887B (en) * | 2010-12-03 | 2013-06-05 | 三达膜科技（厦门）有限公司 | Preparation method of nanoscale zirconium phosphate silver-carrying composite inorganic antimicrobial agent |
-
2012
- 2012-11-28 JP JP2012259331A patent/JP5525027B2/en active Active
-
2013
- 2013-11-08 TW TW102140669A patent/TWI634906B/en not_active IP Right Cessation
- 2013-11-20 SG SG11201504134SA patent/SG11201504134SA/en unknown
- 2013-11-20 WO PCT/JP2013/081294 patent/WO2014084099A1/en active Application Filing
- 2013-11-20 CN CN201380062201.8A patent/CN104968322B/en active Active
- 2013-11-20 KR KR1020157014201A patent/KR101601618B1/en active IP Right Grant
-
2015
- 2015-12-15 HK HK15112296.9A patent/HK1211480A1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| SG11201504134SA (en) | 2015-07-30 |
| WO2014084099A1 (en) | 2014-06-05 |
| KR101601618B1 (en) | 2016-03-08 |
| CN104968322B (en) | 2016-12-07 |
| KR20150089021A (en) | 2015-08-04 |
| JP2014105186A (en) | 2014-06-09 |
| TWI634906B (en) | 2018-09-11 |
| JP5525027B2 (en) | 2014-06-18 |
| HK1211480A1 (en) | 2016-05-27 |
| CN104968322A (en) | 2015-10-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| TWI634906B (en) | Skin external preparation | |
| JP6010418B2 (en) | Emulsified composition | |
| JP5053887B2 (en) | Oil-in-water emulsion composition | |
| WO2010090219A1 (en) | Hair conditioner composition and low-energy manufacturing method for the same | |
| JP5429967B2 (en) | Oil-in-water emulsified skin external preparation | |
| JP4489139B1 (en) | Oil-in-water emulsified skin cosmetic | |
| JP2007238538A (en) | Gel composition and pack cosmetic using the gel composition | |
| TWI516278B (en) | Water-in-oil type emulsifying cosmetic | |
| JP4093735B2 (en) | Emulsified external skin preparation | |
| JP6118546B2 (en) | Oil-in-water emulsion composition | |
| JP2011195511A (en) | Oil-in-water type emulsified skin external composition | |
| JP2013053088A (en) | Powder-containing external skin care preparation | |
| JP7373264B2 (en) | sunscreen cosmetics | |
| JP4330511B2 (en) | Oil-in-water type external composition for skin | |
| JP2012201683A (en) | Cosmetic | |
| JP2012001497A (en) | Oil-in-water emulsion composition | |
| EP2846762A2 (en) | Composition | |
| JP2003267830A (en) | Liquid cosmetic | |
| JP2013203678A (en) | Oil-in-water type emulsified skin cosmetic | |
| JP5824323B2 (en) | Water-in-oil emulsion composition | |
| TWI743608B (en) | Skin external preparation | |
| JPH10279417A (en) | Preparation for external use for skin | |
| CN112292112B (en) | Two-phase composition for topical application | |
| JP2001335411A (en) | Hydrophilic emulsified skin care preparation | |
| JP2024089200A (en) | Cosmetics |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Annulment or lapse of patent due to non-payment of fees |