TW201350152A - Blood filter medium and method for reducing blood loss rate - Google Patents
Blood filter medium and method for reducing blood loss rate Download PDFInfo
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本發明是有關於一種血液濾材，特別是指包含一水刺型親水不織布層及一熔噴型親水不織布層的血液濾材。 The present invention relates to a blood filter material, and more particularly to a blood filter material comprising a hydroentangled hydrophilic nonwoven fabric layer and a meltblown hydrophilic nonwoven fabric layer.
輸血是一種治療措施，可拯救許多病患的生命，但是也有相當比例的病患在輸血後產生了不同程度的輸血反應，如非溶血性發熱反應、病毒感染或人類白細胞抗原(human leukocyte antigen，簡稱HLA)異體免疫的發生。該等輸血反應的發生主要起因於白血球的存在，在輸血時將大量的外來細胞注入病患體內，致使該外來細胞中的白血球攻擊病患細胞，繼而引起發燒或排斥現象，因此，於輸血時需將血液中的白血球過濾並去除，俾減低該等輸血反應的發生，以提升輸血用的血液及醫療品質。美國血庫協會(American Association of Blood Banks)針對輸血用的血液進行規範，其中，輸血用的血液中的白血球的含量需低於5×106個/unit，才能做為輸血用的血液。 Blood transfusion is a treatment that can save the lives of many patients, but a significant proportion of patients have different degrees of transfusion reactions after transfusion, such as non-hemolytic febrile reactions, viral infections or human leukocyte antigens (human leukocyte antigens). Referred to as HLA) the occurrence of allogeneic immunity. The occurrence of such transfusion reactions is mainly caused by the presence of white blood cells, which inject a large amount of foreign cells into the patient during blood transfusion, causing the white blood cells in the foreign cells to attack the patient cells, which in turn causes fever or rejection, and therefore, during transfusion The white blood cells in the blood need to be filtered and removed, and the occurrence of such transfusion reactions is reduced to improve the blood and medical quality for blood transfusion. The American Association of Blood Banks regulates blood for blood transfusion, in which the amount of white blood cells in blood for transfusion needs to be less than 5 × 10 6 /unit to be used as blood for blood transfusion.
US 7524425揭示一種包含一多孔元件的白血球過濾器。該多孔元件包括至少一具有可適合白血球通過的孔隙的纖維網(fibrous web)，其中，該纖維網是由一疏水性纖維、一以塗佈方式形成在該疏水性纖維上的親水性聚合物，及一平均直徑低於30μm的吸附粒子(adsorbent particle)經熔噴法所製得。雖該白血球過濾器可滿足美國血庫協會的規範，然，該白血球過濾器的製備較繁瑣，且生產成本較高 ，不符合業者的使用效益及成本效益。且使用其過濾血液時，因該製法所獲得的纖維網孔隙小，且血液僅會局部通過，無法全面均勻地在該多孔元件表面上擴散，導致過濾面積小，繼而造成過濾時間長、易阻塞且易使得過濾後的血液損失。再者，該白血球過濾器需使用30層，才能有效將白血球含量降低至0.1×105個/unit至1.5×105個/unit。 No. 7,524,425 discloses a white blood cell filter comprising a porous element. The porous member comprises at least one fibrous web having pores adapted to pass white blood cells, wherein the fibrous web is a hydrophobic polymer, a hydrophilic polymer formed on the hydrophobic fibers by coating. And an adsorbent particle having an average diameter of less than 30 μm is obtained by a melt blow method. Although the white blood cell filter can meet the specifications of the American Blood Bank Association, the white blood cell filter is relatively cumbersome to prepare, and the production cost is high, which does not meet the utility efficiency and cost effectiveness of the operator. When the blood is filtered by using the method, the pores obtained by the preparation method have small pores, and the blood only partially passes, and cannot spread uniformly on the surface of the porous member, resulting in a small filtration area, which in turn causes long filtration time and is easy to block. And easy to make the blood loss after filtration. Furthermore, the white blood cell filter needs to use 30 layers in order to effectively reduce the white blood cell content to 0.1 × 10 5 /unit to 1.5 × 10 5 /unit.
有鑑於上述，仍有需要發展出一種有助於降低血液損失率且成本低的血液濾材，以符合業者所需。 In view of the above, there is still a need to develop a blood filter material that contributes to lowering the rate of blood loss and which is low in cost to meet the needs of the industry.
因此，本發明之第一目的，即在提供一種有助於降低血液損失率，且成本低的血液濾材。 Accordingly, it is a first object of the present invention to provide a blood filter material which contributes to a reduction in blood loss rate and which is low in cost.
於是，本發明血液濾材，包含至少一複合單元，該複合單元含有：至少一層水刺型親水不織布層；及至少一層熔噴型親水不織布層，位於該水刺型親水不織布層上；其中，該水刺型親水不織布層包括複數條纖維材，且該等纖維材的橫截面分別具有至少兩端，且該兩端形成一具有毛細作用的間隙。 Therefore, the blood filter material of the present invention comprises at least one composite unit comprising: at least one layer of hydroentangled hydrophilic nonwoven fabric layer; and at least one layer of melt-blown hydrophilic nonwoven fabric layer on the hydroentangled hydrophilic nonwoven fabric layer; The hydroentangled hydrophilic nonwoven fabric layer comprises a plurality of fibrous materials, and the cross-sections of the fibrous materials each have at least two ends, and the two ends form a gap having a capillary action.
本發明之第二目的，即在提供一種減少血液損失率的方法。 A second object of the present invention is to provide a method of reducing the rate of blood loss.
於是，本發明減少血液損失率的方法是利用如上所述之血液濾材來過濾血液。 Thus, the method of the present invention for reducing the rate of blood loss is to filter blood using a blood filter material as described above.
本發明之功效：透過該間隙可增加該血液濾材的導流 及擴散效過，以及增加過濾面積，以降低血液損失率，同時，可提升該血液濾材對血液的過濾效能，以減少血液過濾時間。再者，該血液濾材的生產成本低，可符合業者的使用效益及成本效益。 The effect of the invention: the drainage of the blood filter material can be increased through the gap And the diffusion effect, and increase the filtration area to reduce the blood loss rate, at the same time, can improve the blood filter efficiency of the blood filter to reduce blood filtration time. Moreover, the production cost of the blood filter material is low, which can meet the utility efficiency and cost effectiveness of the operator.
本發明透過該水刺型親水不織布層中具有毛細現象的間隙，可使血液接觸到該水刺型親水不織布層時，藉由間隙達到左右擴散及導流效果，增加血液接觸面積，繼而使血液均勻地全面分佈在該水刺型親水不織布層的表面上，並均勻通過該水刺型親水不織布層，接著，血液因已藉由該水刺型親水不織布層達到全面擴散且分佈的效果，當血液接觸該熔噴型親水不織布層時，可使血液均勻全面地接觸並通過該熔噴型親水不織布層，同時，可提升該血液濾材對血液的過濾效能，以減少血液過濾時間。 The present invention transmits a gap having a capillary phenomenon in the spunlace hydrophilic non-woven fabric layer, so that when the blood contacts the hydroentangled hydrophilic non-woven fabric layer, the gap can be diffused and guided by the gap to increase the blood contact area, and then the blood is made. Uniformly distributed uniformly on the surface of the spunlace hydrophilic nonwoven fabric layer and uniformly passed through the spunlace hydrophilic nonwoven fabric layer, and then, the blood has been fully diffused and distributed by the hydroentangled hydrophilic nonwoven fabric layer. When the blood contacts the melt-blown hydrophilic non-woven fabric layer, the blood can be uniformly and completely contacted and passed through the melt-blown hydrophilic non-woven fabric layer, and at the same time, the blood filter material can be improved in blood filtration efficiency to reduce blood filtration time.
本發明血液濾材，包含至少一複合單元，該複合單元含有：至少一層水刺型親水不織布層；及至少一層熔噴型親水不織布層，位於該水刺型親水不織布層上；其中，該水刺型親水不織布層包括複數條纖維材，且該等纖維材的橫截面分別具有至少兩端，且該兩端形成一具有毛細作用的間隙。該等纖維材的橫截面如圖1所示，該等纖維材的橫截面分別具有至少兩端7，且該兩端7形成一具有毛細作用的間隙71。該圖1僅為例示說明之用，不 應被解釋本發明實施之限制。 The blood filter material of the present invention comprises at least one composite unit comprising: at least one layer of hydroentangled hydrophilic non-woven fabric layer; and at least one layer of melt-blown hydrophilic non-woven fabric layer on the hydroentangled hydrophilic non-woven fabric layer; wherein the hydroentangled layer The hydrophilic non-woven fabric layer comprises a plurality of fibrous materials, and the cross-sections of the fibrous materials each have at least two ends, and the two ends form a gap having a capillary action. The cross-section of the fibrous materials is as shown in Fig. 1. The cross-sections of the fibrous materials each have at least two ends 7, and the ends 7 form a gap 71 having a capillary action. Figure 1 is for illustrative purposes only, not The limitations of the practice of the invention should be construed.
較佳地，該等纖維複合材的橫截面分別具有一中心部及複數個自該中心部向外延伸的第一延伸部，且任兩相鄰的第一延伸部的末端形成一具有毛細作用的間隙。該等纖維材的橫截面如圖2所示，該等纖維複合材的橫截面分別具有一中心部8及複數個自該中心部8向外延伸的第一延伸部81，且任兩相鄰的第一延伸部81的末端811形成一具有毛細作用的間隙82。該圖2僅為例示說明之用，不應被解釋本發明實施之限制。 Preferably, the cross-sections of the fiber composites respectively have a central portion and a plurality of first extending portions extending outward from the central portion, and the ends of any two adjacent first extending portions form a capillary action. Clearance. The cross-sections of the fiber materials are as shown in FIG. 2, and the cross-sections of the fiber composites respectively have a central portion 8 and a plurality of first extending portions 81 extending outward from the central portion 8, and any two adjacent portions The end 811 of the first extension 81 forms a gap 82 having a capillary action. This Figure 2 is for illustrative purposes only and should not be construed as limiting the implementation of the invention.
較佳地，該等纖維複合材的橫截面分別還具有一自該第一延伸部的末端延伸的第二延伸部，且該第二延伸部包括二相反且分別朝向相鄰的第二延伸部的尾端，以及任兩相鄰的第二延伸部之相鄰近的尾端形成一具有毛細作用的間隙。該等纖維材的橫截面如圖3及圖4所示，該等纖維複合材的橫截面分別具有一中心部8、複數個自該中心部8向外延伸的第一延伸部81，及複數個自該第一延伸部81的末端811延伸的第二延伸部83，且該第二延伸部83包括二相反且分別朝向相鄰的第二延伸部83的尾端831，以及任兩相鄰的第二延伸部83之相鄰近的尾端831形成一具有毛細作用的間隙82。該圖3及圖4僅為例示說明之用，不應被解釋本發明實施之限制。 Preferably, the cross-sections of the fiber composites each have a second extension extending from the end of the first extension, and the second extension includes two opposite and respectively adjacent second extensions The trailing end, and the adjacent trailing ends of any two adjacent second extensions, form a capillary-like gap. The cross-sections of the fiber materials have a central portion 8, a plurality of first extending portions 81 extending outward from the central portion 8, and a plurality of cross-sections of the fiber composites, respectively. a second extension 83 extending from the end 811 of the first extension 81, and the second extension 83 includes two opposite ends and respectively facing the trailing end 831 of the adjacent second extension 83, and any two adjacent The adjacent end 831 of the second extension 83 forms a capillary 82 having a capillary action. 3 and 4 are for illustrative purposes only and are not to be construed as limiting the implementation of the invention.
較佳地，該間隙範圍為1μm至8μm。 Preferably, the gap ranges from 1 μm to 8 μm.
該水刺型親水不織布層是由一包括複數條纖維材的纖維網經由水刺法(water-jet entangling)所製成。該水刺法是 利用高壓水流垂直射向該纖維網，且該水流使得該纖維網中的纖維材相互纏結而成的方法。較佳地，該水刺型親水不織布層的基重範圍為10 g/m2至200 g/m2。 The spunlace hydrophilic nonwoven fabric layer is formed by a water-jet entangling of a web comprising a plurality of fibrous materials. The hydroentangling method is a method in which a high-pressure water stream is directed perpendicularly to the fiber web, and the water flow causes the fiber materials in the fiber web to be entangled with each other. Preferably, the spunlace hydrophilic nonwoven fabric layer has a basis weight ranging from 10 g/m 2 to 200 g/m 2 .
該等纖維材的材質分別為熱可塑性(thermoplastic)樹脂。該熱可塑性樹脂包含但不限於聚酯(polyester)、聚乙烯(polyethylene)或聚丙烯(polypropylene)等。該聚酯包含但不限於聚對苯二甲酸乙二酯(polyethylene terephthalate，簡稱PET)或聚對苯二甲酸丁二酯(polybutylene terephthalate)等。較佳地，該等纖維材的長度範圍為38mm至64mm。較佳地，該等纖維材的細度(fineness)範圍為0.5丹尼至6.0丹尼(denier)。 The materials of the fibrous materials are each a thermoplastic resin. The thermoplastic resin includes, but is not limited to, polyester, polyethylene, polypropylene, and the like. The polyester includes, but is not limited to, polyethylene terephthalate (PET) or polybutylene terephthalate. Preferably, the length of the fibers ranges from 38 mm to 64 mm. Preferably, the fineness of the fibrous materials ranges from 0.5 denier to 6.0 denier.
該水刺型親水不織布層還包括複數條橫截面為圓形的纖維材。該橫截面為圓形的纖維材的材質包含但不限於聚對苯二甲酸乙二酯或聚對苯二甲酸丁二酯等。較佳地，以該橫截面具有毛細作用的間隙的纖維材及橫截面為圓形的纖維材的總量為100wt%，該橫截面具有毛細作用的間隙的纖維材的使用量範圍為10 wt%至90 wt%。 The spunlace hydrophilic nonwoven fabric layer further includes a plurality of fibrous materials having a circular cross section. The material of the fibrous material having a circular cross section includes, but is not limited to, polyethylene terephthalate or polybutylene terephthalate. Preferably, the total amount of the fibrous material having a capillary action in the cross section and the fibrous material having a circular cross section is 100% by weight, and the amount of the fibrous material having the capillary action gap in the cross section is 10 wt. % to 90 wt%.
較佳地，該熔噴型親水不織布層是由複數條纖維複合材彼此交錯所構成，其中，該等纖維複合材是將一包含一聚合物與一親水劑的混合物經由熔噴法(melt-blown)所製成。該熔噴法是利用高壓熱空氣將該混合物拉伸成複數條纖維複合材，進而堆疊而成。較佳地，該等纖維複合材的細度範圍為0.3丹尼至6.0丹尼。該聚合物包含但不限於聚烯烴系聚合物。較佳地，該聚烯烴系聚合物是擇自於聚丙烯 。該親水劑包含但不限於長效熱熔添加型親水劑，如市售親水劑IRGASURF TM HL560(購自BASF公司)。較佳地，該熔噴型親水不織布層的基重範圍為5 g/m2至300 g/m2。較佳地，以該混合物的總量為100wt%，該親水劑的使用量範圍為1wt%至5wt%。 Preferably, the melt-blown hydrophilic nonwoven fabric layer is composed of a plurality of fiber composite materials interlaced with each other, wherein the fiber composite material is a melt-blown method (melt-) comprising a mixture of a polymer and a hydrophilic agent. Blown) made. The melt-blown method uses a high-pressure hot air to stretch the mixture into a plurality of fiber composite materials, which are then stacked. Preferably, the fiber composites have a fineness ranging from 0.3 denier to 6.0 denier. The polymer includes, but is not limited to, a polyolefin-based polymer. Preferably, the polyolefin-based polymer is selected from polypropylene. The hydrophilizing agent comprising a long-acting but not limited to hot melt additive hydrophilizing agents, hydrophilizing agents such as commercially available IRGASURF TM HL560 (commercially available from BASF). Preferably, the meltblown hydrophilic nonwoven fabric layer has a basis weight ranging from 5 g/m 2 to 300 g/m 2 . Preferably, the hydrophilic agent is used in an amount ranging from 1% by weight to 5% by weight based on 100% by weight of the total of the mixture.
較佳地，該血液濾材包含一複合單元，且該複合單元是擇自於第一複合單元、第二複合單元、第三複合單元或第四複合單元，其中，該第一複合單元是由一層水刺型親水不織布層及一層位於該水刺型親水不織布層上之熔噴型親水不織布層所構成；該第二複合單元是由一層水刺型親水不織布層及二層位於該水刺型親水不織布層上之熔噴型親水不織布層所構成；該第三複合單元是由一層水刺型親水不織布層及三層位於該水刺型親水不織布層上之熔噴型親水不織布層所構成；該第四複合單元是由一層水刺型親水不織布層及五層位於該水刺型親水不織布層上之熔噴型親水不織布層所構成。 Preferably, the blood filter material comprises a composite unit, and the composite unit is selected from a first composite unit, a second composite unit, a third composite unit or a fourth composite unit, wherein the first composite unit is composed of a layer a spunlaced hydrophilic non-woven fabric layer and a melt-blown hydrophilic non-woven fabric layer on the spunlace hydrophilic non-woven fabric layer; the second composite unit is composed of a layer of hydroentangled hydrophilic non-woven fabric layer and two layers located at the hydroentangled hydrophilic layer The melt-blown hydrophilic non-woven fabric layer on the non-woven layer; the third composite unit is composed of a layer of hydroentangled hydrophilic non-woven fabric layer and three layers of melt-blown hydrophilic non-woven fabric layer on the spunlace hydrophilic non-woven fabric layer; The fourth composite unit is composed of a layer of spunlaced hydrophilic non-woven fabric layer and five layers of melt-blown hydrophilic non-woven fabric layer on the spunlace hydrophilic non-woven fabric layer.
較佳地，該血液濾材包含多個複合單元，且每一個複合單元是擇自於第一複合單元、第二複合單元、第三複合單元或第四複合單元，其中，該第一複合單元是由一層水刺型親水不織布層及一層位於該水刺型親水不織布層上之熔噴型親水不織布層所構成；該第二複合單元是由一層水刺型親水不織布層及二層位於該水刺型親水不織布層上之熔噴型親水不織布層所構成；該第三複合單元是由一層水刺型親水不織布層及三層位於該水刺型親水不織布層上之 熔噴型親水不織布層所構成；該第四複合單元是由一層水刺型親水不織布層及五層位於該水刺型親水不織布層上之熔噴型親水不織布層所構成。 Preferably, the blood filter material comprises a plurality of composite units, and each composite unit is selected from a first composite unit, a second composite unit, a third composite unit or a fourth composite unit, wherein the first composite unit is The utility model comprises a layer of hydroentangled hydrophilic non-woven fabric layer and a melt-blown hydrophilic non-woven fabric layer on the hydroentangled hydrophilic non-woven fabric layer; the second composite unit is composed of a layer of hydroentangled hydrophilic non-woven fabric layer and two layers located on the spunlace The melt-blown hydrophilic non-woven fabric layer on the hydrophilic non-woven fabric layer; the third composite unit is composed of a layer of hydroentangled hydrophilic non-woven fabric layer and three layers on the hydroentangled hydrophilic non-woven fabric layer The melt-blown hydrophilic nonwoven fabric layer is composed of a layer of a hydroentangled hydrophilic nonwoven fabric layer and five layers of a melt-blown hydrophilic nonwoven fabric layer on the spunlace hydrophilic nonwoven fabric layer.
較佳地，該血液濾材為第一複合單元。 Preferably, the blood filter material is a first composite unit.
較佳地，該血液濾材為第三複合單元。 Preferably, the blood filter material is a third composite unit.
較佳地，該血液濾材為至少一個第四複合單元。 Preferably, the blood filter material is at least one fourth composite unit.
較佳地，該血液濾材為二個第四複合單元。 Preferably, the blood filter material is two fourth composite units.
當該第一複合單元、該第二複合單元、該第三複合單元及該第四複合單元同時使用，該等複合單元的相對位置及數目並無特別的限制，例如，形成位置由下而上依序為三個第四複合單元、一個第三複合單元、一個第二複合單元及一個第一複合單元，或者，形成位置由下而上依序為一個第一複合單元、一個第三複合單元、一個第二複合單元及三個第四複合單元等。 When the first composite unit, the second composite unit, the third composite unit, and the fourth composite unit are used at the same time, the relative positions and numbers of the composite units are not particularly limited, for example, the formation position is from bottom to top. The sequence is three fourth composite units, one third composite unit, one second composite unit and one first composite unit, or the formation position is a first composite unit and a third composite unit from bottom to top. , a second composite unit and three fourth composite units.
較佳地，該血液濾材由下而上依序為三個第四複合單元、一個第三複合單元、一個第二複合單元及一個第一複合單元。 Preferably, the blood filter material is sequentially composed of three fourth composite units, one third composite unit, one second composite unit and one first composite unit from bottom to top.
有關本發明之前述及其他技術內容、特點與功效，在以下配合參考圖式之四個較佳實施例的詳細說明中，將可清楚的呈現。 The above and other technical contents, features and advantages of the present invention will be apparent from the following detailed description of the preferred embodiments of the invention.
在本發明被詳細描述之前，要注意的是，在以下的說明內容中，類似的元件是以相同的編號來表示。 Before the present invention is described in detail, it is noted that in the following description, similar elements are denoted by the same reference numerals.
參閱圖5，本發明血液濾材的第一較佳實施例包含一個第一複合單元1，且該第一複合單元1包括一水刺型親水不 織布層11及一熔噴型親水不織布層12。 Referring to Figure 5, a first preferred embodiment of the blood filter material of the present invention comprises a first composite unit 1 and the first composite unit 1 comprises a hydroentangled hydrophilic The woven layer 11 and a meltblown hydrophilic nonwoven layer 12 are provided.
參閱圖6，本發明血液濾材的第二較佳實施例與第一較佳實施例不同處在於：該第二較佳實施例包含一個第三複合單元3，其中，該第三複合單元3是由一層水刺型親水不織布層31及三層疊置於該水刺型親水不織布層31下方之熔噴型親水不織布層32所構成。該第三複合單元3中的水刺型親水不織布層31與熔噴型親水不織布層32，是與第一複合單元1中的水刺型親水不織布層11與熔噴型親水不織布層12相同，故不再贅述。 Referring to Figure 6, a second preferred embodiment of the blood filter of the present invention differs from the first preferred embodiment in that the second preferred embodiment includes a third composite unit 3, wherein the third composite unit 3 is A layer of the hydroentangled hydrophilic nonwoven fabric layer 31 and a melt-blown hydrophilic nonwoven fabric layer 32 laminated under the spunlace hydrophilic nonwoven fabric layer 31 are formed. The spunlace hydrophilic non-woven fabric layer 31 and the melt-blown hydrophilic nonwoven fabric layer 32 in the third composite unit 3 are the same as the hydroentangled hydrophilic non-woven fabric layer 11 and the melt-blown hydrophilic nonwoven fabric layer 12 in the first composite unit 1. Therefore, it will not be repeated.
參閱圖7，本發明血液濾材的第三較佳實施例與第一較佳實施例不同處在於：該第三較佳實施例包含一個第四複合單元4，其中，該第四複合單元4分別是由一層水刺型親水不織布層41及五層疊置於該水刺型親水不織布層下方之熔噴型親水不織布層42所構成。該第四複合單元4中的水刺型親水不織布層41與熔噴型親水不織布層42，是與第一複合單元1中的水刺型親水不織布層11與熔噴型親水不織布層12相同，故不再贅述。 Referring to FIG. 7, a third preferred embodiment of the blood filter material of the present invention is different from the first preferred embodiment in that the third preferred embodiment includes a fourth composite unit 4, wherein the fourth composite unit 4 is respectively It is composed of a layer of hydroentangled hydrophilic non-woven fabric layer 41 and a melt-blown hydrophilic nonwoven fabric layer 52 which is placed under the spunlace hydrophilic non-woven fabric layer. The spunlace hydrophilic non-woven fabric layer 41 and the melt-blown hydrophilic nonwoven fabric layer 42 in the fourth composite unit 4 are the same as the hydroentangled hydrophilic non-woven fabric layer 11 and the melt-blown hydrophilic nonwoven fabric layer 12 in the first composite unit 1. Therefore, it will not be repeated.
參閱圖8，本發明血液濾材的第四較佳實施例與第一較佳實施例不同處在於：該第四較佳實施例包含一個第一複合單元1、一個設置在第一複合單元1下方之第二複合單元2、一個設置在第二複合單元2下方之第三複合單元3，及設置在第三複合單元3下方之三個第四複合單元4。 Referring to FIG. 8, a fourth preferred embodiment of the blood filter material of the present invention is different from the first preferred embodiment in that the fourth preferred embodiment includes a first composite unit 1 and a lower portion of the first composite unit 1. The second composite unit 2, a third composite unit 3 disposed below the second composite unit 2, and three fourth composite units 4 disposed below the third composite unit 3.
本發明減少血液損失率的方法，是利用如上所述之血液濾材來過濾血液。參閱圖9，於血液輸血時使用該血液濾 材1進行過濾，血液流動方向5是與該血液濾材(如第一複合單元1)垂直，血液會流經該水刺型親水不織布層11，並透過該水刺型親水不織布層11橫截面的間隙，使血液快速被導流，再經由熔噴型親水不織布層12進行過濾，即可獲得一濾液6，值得說明的是血液通過的最後一層並不限於是熔噴型親水不織布層，也可以是水刺型親水不織布層。 The method of the present invention for reducing the rate of blood loss is to filter blood using a blood filter material as described above. Referring to Figure 9, the blood filter is used for blood transfusion. The material 1 is filtered, and the blood flow direction 5 is perpendicular to the blood filter material (such as the first composite unit 1), and the blood flows through the hydroentangled hydrophilic nonwoven fabric layer 11 and passes through the cross section of the hydroentangled hydrophilic nonwoven fabric layer 11. The gap allows the blood to be quickly diverted and then filtered through the melt-blown hydrophilic nonwoven layer 12 to obtain a filtrate 6. It is worth noting that the last layer of blood passage is not limited to the melt-blown hydrophilic non-woven layer. It is a spunlace type hydrophilic non-woven fabric layer.
本發明將就以下實施例來作進一步說明，但應瞭解的是，該實施例僅為例示說明之用，而不應被解釋為本發明實施之限制。 The present invention will be further illustrated by the following examples, but it should be understood that this embodiment is intended to be illustrative only and not to be construed as limiting.
依據美國材料與試驗學會(American Society for Testing and Materials,ASTM)編號D3776-85的檢測標準在溫度23±0.5℃、相對溼度65±2%，一般大氣壓力下，在電子天評量測試片質量，並計算試片單位面積質量。 According to the American Society for Testing and Materials (ASTM) No. D3776-85 test standard at a temperature of 23 ± 0.5 ° C, relative humidity of 65 ± 2%, under normal atmospheric pressure, in the electronic days to measure the quality of the test piece And calculate the mass per unit area of the test piece.
將65wt%的該橫截面具有毛細作用的間隙的聚對苯二甲酸乙二酯纖維(橫截面如圖4所示，且間隙為3.0±1.0μm)與35 wt%的橫截面為圓形的聚對苯二甲酸乙二酯纖維混合形成一纖維網，且該等纖維的長度為38mm時，該等纖維的細度為2.0丹尼。將該纖維網導入一水刺設備(廠商：康那香；型號：106N52)，即可獲得一水刺型親水不織布，且該水刺型親水不織布的基重範圍為55±5g/m2。 65 wt% of a polyethylene terephthalate fiber having a capillary action gap (having a cross section as shown in Fig. 4 and a gap of 3.0 ± 1.0 μm) and a cross section of 35 wt% is circular The polyethylene terephthalate fibers were mixed to form a web, and when the fibers had a length of 38 mm, the fibers had a fineness of 2.0 denier. The fiber web was introduced into a spunlace apparatus (manufacturer: ConA; Model: 106N52) to obtain a spunlace type hydrophilic non-woven fabric, and the spunlace type hydrophilic non-woven fabric had a basis weight of 55 ± 5 g/m 2 .
將97克的聚丙烯與3克的親水劑(廠商：BASF公司；型號IRGASURF TM HL560)混合形成一混合物，接著，將該混合物導入一熔噴設備(廠商：康那香；型號：106NU1)，即可獲得一熔噴型親水不織布，且該熔噴型親水不織布的基重範圍為20±2g/m2。 97 g of polypropylene and 3 g of hydrophilizing agent (Manufacturer: BASF Corporation; Model IRGASURF TM HL560) mixed to form a mixture, then the mixture is introduced into a meltblowing apparatus (Manufacturer: KNH; Model: 106NU1), A melt-blown hydrophilic nonwoven fabric was obtained, and the melt-blown hydrophilic nonwoven fabric had a basis weight of 20 ± 2 g/m 2 .
將多袋廢棄的濃縮紅血球液倒出混合均勻後得到一混合液。取220 mL混合液，再加入30 mL且濃度為0.9wt%的生理食鹽水進行混合，即獲得一血液樣品，其中，該血液樣品中的白血球含量為8.42×108個/unit。 A plurality of bags of discarded concentrated red blood cell liquid are poured out and mixed uniformly to obtain a mixed solution. A blood sample was obtained by mixing 220 mL of the mixture and adding 30 mL of a physiological saline solution having a concentration of 0.9% by weight, wherein the blood sample contained 8.42 × 10 8 cells/unit.
該血液濾材由上而下包含一個第一複合單元、一個設置在第一複合單元下方之第二複合單元、一個設置在第二複合單元下方之第三複合單元，及三個設置在第三複合單元下方之第四複合單元。該第一複合單元分別是由一層合成例1之水刺型親水不織布層，及一層疊置於合成例1之水刺型親水不織布層下方之合成例2之熔噴型親水不織布層所構成。該第二複合單元分別是由一層合成例1之水刺型親水不織布層，及二層疊置於合成例1之水刺型親水不織布層下方之合成例2之熔噴型親水不織布層所構成。該第三複合單元分別是由一層合成例1之水刺型親水不織布層，及三層疊置於合成例1之水刺型親水不織布層下方之合成例2之熔噴型親水不織布層所構成。該等第四複合單元分別是由一層合成例1之水刺型親水不織布層，及五層 疊置於合成例1之水刺型親水不織布層下方之合成例2之熔噴型親水不織布層所構成。 The blood filter material comprises a first composite unit from top to bottom, a second composite unit disposed under the first composite unit, a third composite unit disposed below the second composite unit, and three disposed in the third composite unit. The fourth composite unit below the unit. Each of the first composite units was composed of a layer of the hydroentangled hydrophilic nonwoven fabric layer of Synthesis Example 1 and a melt blown hydrophilic nonwoven fabric layer of Synthesis Example 2 laminated under the hydroentangled hydrophilic nonwoven fabric layer of Synthesis Example 1. Each of the second composite units was composed of one layer of the hydroentangled hydrophilic nonwoven fabric layer of Synthesis Example 1 and two melt-blown hydrophilic nonwoven fabric layers of Synthesis Example 2 which were placed under the spunlace hydrophilic nonwoven fabric layer of Synthesis Example 1. Each of the third composite units was composed of a layer of the hydroentangled hydrophilic nonwoven fabric layer of Synthesis Example 1 and a meltblown hydrophilic nonwoven fabric layer of Synthesis Example 2 which was placed under the spunlace hydrophilic nonwoven fabric layer of Synthesis Example 1. The fourth composite unit is composed of a layer of hydroentangled hydrophilic non-woven fabric layer of Synthesis Example 1, and five layers. The melt-blown hydrophilic nonwoven fabric layer of Synthesis Example 2 was placed under the spunlace hydrophilic nonwoven fabric layer of Synthesis Example 1.
將該血液樣品通過該血液濾材進行過濾，該血液濾材的平面是與血液流動方向垂直，並先與該第一複合單元之水刺型親水不織布層接觸。過濾後，所得濾液經自動血球計數分析儀(Automated haematology cell counting devices，型號：Sysmex XE-2100)分析後，該濾液中所含的白血球殘餘量為4.78×105個/unit，白血球移除率為99.94%、紅血球回收率為94.97%，且血液損失率為4.36±1.08%。相較於US 7524425的白血球過濾器，本發明血液濾材使用27層即可有效地將白血球含量降低。 The blood sample is filtered through the blood filter material, the plane of the blood filter material being perpendicular to the direction of blood flow, and first contacting the spunlace hydrophilic nonwoven fabric layer of the first composite unit. After filtration, the obtained filtrate was analyzed by Automated haematology cell counting devices (Model: Sysmex XE-2100), and the residual amount of white blood cells contained in the filtrate was 4.78×10 5 units/unit, and the white blood cell removal rate was obtained. The recovery rate was 99.94%, the red blood cell recovery rate was 94.97%, and the blood loss rate was 4.36±1.08%. Compared to the white blood cell filter of US 7524425, the blood filter of the present invention can effectively reduce the white blood cell content by using 27 layers.
將多袋廢棄的濃縮紅血球液倒出混合均勻後得到一混合液。取100 mL混合液，再加入10 mL且濃度為0.9wt%的生理食鹽水進行混合，即獲得一血液樣品。 A plurality of bags of discarded concentrated red blood cell liquid are poured out and mixed uniformly to obtain a mixed solution. A 100 mL mixture was taken, and 10 mL of a physiological saline solution having a concentration of 0.9% by weight was added for mixing to obtain a blood sample.
該血液濾材為一個第三複合單元，其中，該第三複合單元分別是由一層合成例1之水刺型親水不織布層，及三層疊置於合成例1之水刺型親水不織布層下方之合成例2之熔噴型親水不織布層所構成。 The blood filter material is a third composite unit, wherein the third composite unit is composed of one layer of the hydroentangled hydrophilic non-woven fabric layer of Synthesis Example 1, and the three layers are laminated under the hydroentangled hydrophilic non-woven fabric layer of Synthesis Example 1. The melt-blown hydrophilic nonwoven fabric layer of Example 2 was composed.
將該血液樣品通過該血液濾材進行過濾，該血液濾材的平面是與血液流動方向垂直，並先與該第三複合單元之水刺型親水不織布層接觸。過濾後，所得濾液經自動血球計數分析儀分析後，該濾液中，白血球移除率為76%、紅血球回收率為96%，且血液損失率為2%。 The blood sample is filtered through the blood filter material, the plane of the blood filter material being perpendicular to the direction of blood flow, and first contacting the hydroentangled hydrophilic nonwoven fabric layer of the third composite unit. After filtration, the filtrate was analyzed by an automatic blood cell counter analyzer, and the leukocyte removal rate was 76%, the red blood cell recovery rate was 96%, and the blood loss rate was 2%.
實施例3至5及比較例1分別是以與實施例2相同的步驟進行血液過濾，不同的地方在於：改變血液濾材，如表1所示。 Each of Examples 3 to 5 and Comparative Example 1 was subjected to blood filtration in the same manner as in Example 2 except that the blood filter material was changed as shown in Table 1.
相較於比較例1的血液濾材可知，實施例1至5的血液濾材可有效地減少血液損失率，表示透過水刺型親水不織布層可增加該血液濾材的導流及擴散，同時，可提升該血液濾材對血液的過濾效能，以減少血液過濾時間。再者，該實施例1的血液濾材可符合美國血庫協會規範(即白血球殘餘量小於5×106個/unit、紅血球回收率大於85%/unit且血液損失率小於15%/unit)。 Compared with the blood filter material of Comparative Example 1, the blood filter materials of Examples 1 to 5 can effectively reduce the blood loss rate, indicating that the water-staining type hydrophilic nonwoven fabric layer can increase the flow and diffusion of the blood filter material, and at the same time, can be improved. The blood filter material filters the blood to reduce blood filtration time. Furthermore, the blood filter of the embodiment 1 can conform to the American Blood Bank Association specification (ie, the residual amount of white blood cells is less than 5×10 6 units/unit, the red blood cell recovery rate is greater than 85%/unit, and the blood loss rate is less than 15%/unit).
綜上所述，透過該間隙可增加該血液濾材的導流及擴散效果，以及增加過濾面積，以降低血液損失率，同時，可提升該血液濾材對血液的過濾效能，以減少血液過濾時間。且該血液濾材可有效地降低血液中白血球的含量、提高紅血球回收率以及減少血液損失率，以符合美國血庫協會規範，再者，該血液濾材的製備簡單，且生產成本低，可符合業者的使用效益及成本效益，故確實能達成本發明之目的。 In summary, the flow through the gap can increase the flow and diffusion effect of the blood filter material, and increase the filtration area to reduce the blood loss rate, and at the same time, improve the blood filtration efficiency of the blood filter material to reduce the blood filtration time. The blood filter material can effectively reduce the white blood cell content in the blood, increase the red blood cell recovery rate, and reduce the blood loss rate, in order to comply with the American Blood Bank Association specifications. Furthermore, the blood filter material is simple to prepare and has low production cost, which can meet the needs of the industry. The benefits and cost benefits are used, so the object of the invention can be achieved.
惟以上所述者，僅為本發明之較佳實施例而已，當不能以此限定本發明實施之範圍，即大凡依本發明申請專利範圍及發明說明內容所作之簡單的等效變化與修飾，皆仍屬本發明專利涵蓋之範圍內。 The above is only the preferred embodiment of the present invention, and the scope of the invention is not limited thereto, that is, the simple equivalent changes and modifications made by the scope of the invention and the description of the invention are All remain within the scope of the invention patent.
1‧‧‧第一複合單元 1‧‧‧First composite unit
11‧‧‧水刺型親水不織布層 11‧‧‧Spunlace type hydrophilic non-woven layer
12‧‧‧熔噴型親水不織布層 12‧‧‧Melt-spray type hydrophilic non-woven fabric layer
2‧‧‧第二複合單元 2‧‧‧Second composite unit
21‧‧‧水刺型親水不織布層 21‧‧‧Spunlace type hydrophilic non-woven layer
22‧‧‧熔噴型親水不織布層 22‧‧‧Melt-spray type hydrophilic non-woven fabric layer
3‧‧‧第三複合單元 3‧‧‧ third composite unit
31‧‧‧水刺型親水不織布層 31‧‧‧Spunlace type hydrophilic non-woven layer
32‧‧‧熔噴型親水不織布層 32‧‧‧Melt spray type hydrophilic non-woven layer
4‧‧‧第四複合單元 4‧‧‧fourth composite unit
41‧‧‧水刺型親水不織布層 41‧‧‧Spunlace type hydrophilic non-woven fabric layer
42‧‧‧熔噴型親水不織布層 42‧‧‧Melt-spray type hydrophilic non-woven fabric layer
5‧‧‧血液流動方向 5‧‧‧ Blood flow direction
6‧‧‧濾液 6‧‧‧ filtrate
7‧‧‧兩端 7‧‧‧ Both ends
71‧‧‧間隙 71‧‧‧ gap
8‧‧‧中心部 8‧‧‧ Central Department
81‧‧‧第一延伸部 81‧‧‧First Extension
811‧‧‧末端 End of 811‧‧
82‧‧‧間隙 82‧‧‧ gap
83‧‧‧第二延伸部 83‧‧‧Second extension
831‧‧‧尾端 831‧‧‧End
圖1是一示意圖，說明本發明水刺型親水不織布層中該等纖維材的橫截面；圖2是一示意圖，說明本發明水刺型親水不織布層中該等纖維材的橫截面； 圖3是一示意圖，說明本發明水刺型親水不織布層中該等纖維材的橫截面；圖4是一示意圖，說明本發明水刺型親水不織布層中該等纖維材的橫截面；圖5是一示意圖，說明本發明第一較佳實施例的血液濾材；圖6是一示意圖，說明本發明第二較佳實施例的血液濾材；圖7是一示意圖，說明本發明第三較佳實施例的血液濾材；圖8是一示意圖，說明本發明第四較佳實施例的血液濾材；及圖9是一示意圖，說明本發明血液濾材的使用方式。 Figure 1 is a schematic view showing a cross section of the fibrous material in the spunlace hydrophilic nonwoven fabric layer of the present invention; and Figure 2 is a schematic view showing a cross section of the fibrous material in the spunlace hydrophilic nonwoven fabric layer of the present invention; Figure 3 is a schematic view showing a cross section of the fibrous material in the spunlace hydrophilic non-woven fabric layer of the present invention; Figure 4 is a schematic view showing a cross section of the fibrous material in the spunlace hydrophilic non-woven fabric layer of the present invention; Is a schematic view showing a blood filter material according to a first preferred embodiment of the present invention; FIG. 6 is a schematic view showing a blood filter material according to a second preferred embodiment of the present invention; and FIG. 7 is a schematic view showing a third preferred embodiment of the present invention. The blood filter material of the embodiment; Fig. 8 is a schematic view showing the blood filter material of the fourth preferred embodiment of the present invention; and Fig. 9 is a schematic view showing the manner of use of the blood filter material of the present invention.
1‧‧‧第一複合單元 1‧‧‧First composite unit
11‧‧‧水刺型親水不織布層 11‧‧‧Spunlace type hydrophilic non-woven layer
12‧‧‧熔噴型親水不織布層 12‧‧‧Melt-spray type hydrophilic non-woven fabric layer
2‧‧‧第二複合單元 2‧‧‧Second composite unit
21‧‧‧水刺型親水不織布層 21‧‧‧Spunlace type hydrophilic non-woven layer
22‧‧‧熔噴型親水不織布層 22‧‧‧Melt-spray type hydrophilic non-woven fabric layer
3‧‧‧第三複合單元 3‧‧‧ third composite unit
31‧‧‧水刺型親水不織布層 31‧‧‧Spunlace type hydrophilic non-woven layer
32‧‧‧熔噴型親水不織布層 32‧‧‧Melt spray type hydrophilic non-woven layer
4‧‧‧第四複合單元 4‧‧‧fourth composite unit
41‧‧‧水刺型親水不織布層 41‧‧‧Spunlace type hydrophilic non-woven fabric layer
42‧‧‧熔噴型親水不織布層 42‧‧‧Melt-spray type hydrophilic non-woven fabric layer
Claims (9)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| TW101148381A TW201350152A (en) | 2012-06-01 | 2012-12-19 | Blood filter medium and method for reducing blood loss rate |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| TW101119788 | 2012-06-01 | ||
| TW101148381A TW201350152A (en) | 2012-06-01 | 2012-12-19 | Blood filter medium and method for reducing blood loss rate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW201350152A true TW201350152A (en) | 2013-12-16 |
Family
ID=50157744
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW101148381A TW201350152A (en) | 2012-06-01 | 2012-12-19 | Blood filter medium and method for reducing blood loss rate |
Country Status (1)
| Country | Link |
|---|---|
| TW (1) | TW201350152A (en) |
-
2012
- 2012-12-19 TW TW101148381A patent/TW201350152A/en unknown
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