TW201350069A - Apparatus and method for providing metered amounts of ingredient, especially for a tailored nutrition to infants - Google Patents
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本發明係關於一種提供被計量原料成分至營養組合物以用於餵飼嬰兒之設備，特定言之本發明係關於一種用於基於嬰兒特殊需求提供嬰兒個人化營養品之設備。此外，本發明係關於一種用於製備專屬於特定嬰兒之嬰兒營養組合物之方法。 The present invention relates to an apparatus for providing a metered ingredient ingredient to a nutritional composition for feeding an infant, and more particularly to an apparatus for providing an infant personalized nutritional product based on the particular needs of the infant. Furthermore, the invention relates to a method for preparing an infant nutritional composition specific to a particular infant.
在嬰兒出生後4至6個月期間之適當營養品通常認為係其等母親自己的母乳。但是，在一些情況中，用母乳餵養嬰兒不够且可能導致不足的生長。此實例係早產兒，其若完全用人類母乳餵養將需要比母乳中所存在的更高數量之特定養分及更高能量含量。作為在懷孕後第37周前出生的嬰兒之早產兒或早生兒可能具有較低體重。因此，母親之母乳需用一些養分補充。母乳可能對嬰兒不夠之另一實例係對於其等之孕齡較小之嬰兒。此等嬰兒亦將需要一些養分作為母乳之補充。母乳對於嬰兒不足之另一實例可為用其等母親之母乳餵養之足月兒，但母親母乳的一些養分較低，舉例而言含有低脂肪含量或無脂肪。此外，在此情況中，母乳應強化或補充。 Appropriate nutrition during the period of 4 to 6 months after the birth of the baby is generally considered to be the mother's own breast milk. However, in some cases, breastfed infants are insufficient and may result in insufficient growth. This example is a premature infant who will require a higher amount of specific nutrient and higher energy content than that present in breast milk if it is completely breastfed with humans. Premature or early birth as an infant born before the 37th week after pregnancy may have a lower body weight. Therefore, the mother's breast milk needs to be supplemented with some nutrients. Another example of breast milk that may not be sufficient for infants is for babies of younger age. These babies will also need some nutrients as a supplement to breast milk. Another example of breast milk deficiency for infants may be full-term infants who are breastfed with their mothers, but some of the mother's breast milk has lower nutrients, for example, low fat or no fat. In addition, breast milk should be fortified or supplemented in this case.
但是在一些情況中，母乳餵養出於醫療原因而不足或不成功或不可取或母親選擇完全不母乳餵養或母乳餵養達超過幾周之周期。標 準嬰兒配方奶粉為此等情況而研製，但是用嬰兒配方奶粉餵養之嬰兒不一定需要相同量之所有養分。在一些情況中，用嬰兒配方奶粉餵養之嬰兒可能需要比習知嬰兒配方奶粉中所存在的更高含量之一些養分。此可為舉例而言，體重較小之嬰兒，其需要更高脂肪及能量含量。 In some cases, however, breastfeeding is inadequate or unsuccessful or undesirable for medical reasons or the mother chooses to not breastfeed or breastfeed for a period of more than a few weeks. Standard Pre-infant formula is developed for this purpose, but infants fed infant formula do not necessarily need the same amount of all nutrients. In some cases, infants fed with infant formula may require higher levels of nutrients than are present in conventional infant formula. This can be, for example, a baby who is underweight, which requires a higher fat and energy content.
所有上述嬰兒的共同點係可購得之嬰兒配方奶粉及人類母乳均無對於所有嬰兒特定言之早產兒最佳之營養組合物。因此，與人類母乳及習知嬰兒配方奶粉相比，一些嬰兒將需要補充一些養分以使其等之生長最佳化。但是，養分之需求對於嬰兒而言係非常個人化的。 All of the above-mentioned infants have the same point that the commercially available infant formula and human breast milk do not have the best nutritional composition for all infants. Therefore, some infants will need to supplement some nutrients to optimize their growth compared to human breast milk and conventional infant formula. However, the need for nutrients is very personal for babies.
如今，市場上可購得針對足月兒及早產兒兩者之不同嬰兒配方奶粉。但是，所有已知嬰兒配方奶粉具有固定養分量且無法根據個別需求調整養分含量。一些營養補充組合物、強化劑在本技術中亦已知但是其等之所有亦含有特定數量之養分，諸如蛋白質、碳水化合物及脂肪。因此，在本技術中需要一種用於製備為特定嬰兒設計以滿足嬰兒之個別營養需求之專屬的個別營養組合物之設備。此一設備使製備個人化營養品之過程自動化並使製備更方便、簡單及快速。 Today, different infant formulas for both term and premature infants are available on the market. However, all known infant formulas have a fixed nutrient content and are not able to adjust the nutrient content to individual needs. Some nutritional supplement compositions, fortifiers are also known in the art but all of them also contain a specific amount of nutrients such as proteins, carbohydrates and fats. Accordingly, there is a need in the art for an apparatus for preparing a proprietary individual nutritional composition designed for a particular infant to meet the individual nutritional needs of the infant. This device automates the process of preparing personalized nutritional products and makes the preparation more convenient, simple and fast.
國際專利申請案WO2008/111942揭示以一種在使用前針對個別營養需求定製嬰兒配方奶粉之方法。方法包含A)判定將餵給早產兒或低出生體重嬰兒之配方奶粉之所要體積及最佳熱量密度；B)獲得複數個基礎嬰兒配方奶粉，均為液體形式，C)選擇具有高於及低於最佳熱量密度之熱量密度值之基礎液體配方奶粉之兩者，D)計算產生所要體積且具有最佳熱量密度之嬰兒配方奶粉混合物所需之各所選基礎配方奶粉之體積，E)組合所選基礎配方奶粉之所計算體積以產生具有所需體積、最佳熱量密度、介於200與360 mOsm/Kg水之間之容積莫耳滲透濃度及介於609與1082 kcal/L之間之熱量密度之嬰兒配方奶粉混合物，及F)將所得配方奶粉餵給早產兒或低出生體重嬰兒。 International Patent Application WO 2008/111942 discloses a method of customizing infant formula for individual nutritional needs prior to use. The method comprises the following steps: A) determining the desired volume and optimal caloric density of the formula to be fed to the premature or low birth weight infant; B) obtaining a plurality of basic infant formulas in liquid form, C) having a higher and lower selection The basis of the caloric density value of the optimum caloric density, the liquid formula, D) the volume of each selected base formula required to produce the infant formula mixture of the desired volume and having the best caloric density, E) combination The calculated volume of the selected base formula is produced to produce the desired volume, optimum heat density, volumetric osmolality between 200 and 360 mOsm/kg water, and between 609 and 1082 kcal/L. The caloric density of the infant formula mixture, and F) the resulting formula is fed to a premature or low birth weight infant.
但是，WO2008/111942未揭示一種用於基於一些養分之個別需求而製備被計量原料成分之設備。 However, WO 2008/111942 does not disclose an apparatus for preparing a metered raw material component based on the individual needs of some nutrients.
US2011/0052764描述用於施配營養品諸如定製營養飲料之施配器。顧客之一些身體資料被考慮。但是，此設備不適於將餵飼嬰兒之營養組合物且其不提供適於嬰兒之特定需求之定製營養組合物，尤其基於該嬰兒之健康參數。 US 2011/0052764 describes a dispenser for dispensing a nutritional product such as a customized nutritional beverage. Some of the physical information of the customer is considered. However, this device is not suitable for feeding a nutritional composition of an infant and it does not provide a customized nutritional composition suitable for the specific needs of the infant, especially based on the health parameters of the infant.
US2006/278093涉及一種具有至少兩個貯水器之裝置及按需及按所要食用溫度製備流體食物之方法。流體食物可被大多數人食用但本發明更重視如何按所要溫度提供流體產品從而研發特定手段以獲得將特別適於嬰兒食用且基於嬰兒需求定製之個人化營養組合物。 US 2006/278093 relates to a device having at least two water reservoirs and a method of preparing a fluid food on demand and at an edible temperature. Fluid foods are edible by most people but the present invention places more emphasis on how to provide fluid products at the desired temperature to develop specific means to obtain personalized nutritional compositions that will be particularly suitable for infant consumption and tailored to infant needs.
因此，對於可提供旨在補充人類母乳或組成此類嬰兒配方奶粉之營養組合物(其特別為特定嬰兒定製)之設備仍存在未滿足之需求。 Thus, there is still an unmet need for equipment that can provide nutritional compositions that are intended to supplement human breast milk or that make up such infant formula, which are specifically tailored for a particular infant.
因此，本發明之一目標係提供一種用於製備針對特定嬰兒之個別營養需求定製之營養組合物之設備。 Accordingly, it is an object of the present invention to provide an apparatus for preparing a nutritional composition tailored to the individual nutritional needs of a particular infant.
本發明之另一目的係提供根據嬰兒之營養要求可提供特別定製用於餵給嬰兒之營養組合物且包括嬰兒所需之精確數量之養分之設備。本發明之一目標係設備可提供可給予嬰兒作為專門營養餵食即嬰兒配方奶粉組合物或作為如今市場上之市售早產兒或足月兒配方奶粉之補充或作為人類母乳之補充之營養組合物。使用根據本發明之設備，變得可製備個人化營養組合物、此類嬰兒配方奶粉或補充組合物以滿足特定嬰兒之營養需求。藉此，嬰兒將獲得對於該嬰兒最佳之營養餵食及因此獲得最佳生長。 Another object of the present invention is to provide an apparatus that provides a nutritional composition that is specifically tailored for feeding to an infant and that includes the precise amount of nutrients required by the infant, depending on the nutritional requirements of the infant. One of the objects of the present invention is to provide a nutritional composition that can be administered to an infant as a specialized nutrient-fed, that is, an infant formula composition or as a supplement to a commercially available premature or term infant formula on the market or as a supplement to human breast milk. . Using the device according to the invention, it becomes possible to prepare a personalized nutritional composition, such an infant formula or supplement composition to meet the nutritional needs of a particular infant. Thereby, the baby will receive the best nutritional feeding for the baby and thus achieve optimal growth.
本發明之另一目標係提供一種設備，其提供基於來自醫生之輸入而提供為特定嬰兒特別設計之營養組合物，該輸入可與養分要求或嬰兒之特性相關。 Another object of the present invention is to provide an apparatus that provides a nutritional composition specifically designed for a particular infant based on input from a physician, the input being related to a nutrient requirement or an infant's characteristics.
本發明之另一目標係提供一種製備嬰兒營養組合物之方法，其中製作組合物使得其包括特定嬰兒所需之養分量。 Another object of the present invention is to provide a method of preparing an infant nutritional composition wherein the composition is made such that it includes the nutrient content required for a particular infant.
因此，本發明之一態樣係關於一種用於提供被計量原料成分至用於餵飼嬰兒之營養組合物之設備，該設備包括：-複數個容器，各容器容納營養組合物之一或多個原料成分，-複數個輸送裝置，各輸送裝置連接至一容器且經調適以從容器輸送被計量之一或多個原料成分以形成營養組合物之部分至貯器，-輸入構件，諸如圖形使用者介面，其經調適以接收將有關將從設備輸送之一或多個原料成分量之來自使用者之輸入，-控制器，其經調適以回應於來自使用者之輸入而控制由輸送裝置從容器個別輸送之被計量原料成分。 Accordingly, one aspect of the present invention is directed to an apparatus for providing a metered ingredient component to a nutritional composition for feeding an infant, the apparatus comprising: - a plurality of containers each containing one or more nutritional compositions a raw material component, a plurality of delivery devices, each delivery device being coupled to a container and adapted to deliver one or more of the raw material components from the container to form a portion of the nutritional composition to the reservoir, - an input member, such as a graphic a user interface adapted to receive input from a user that will convey one or more raw material components from the device, the controller being adapted to control the delivery device in response to input from the user The metered raw material components are individually delivered from the container.
設備可進一步包括或可存取資料庫，該資料庫儲存存在於容器中之原料成分之(諸)養分含量之值，且其中控制器經調適以：-從資料庫擷取原料成分中之該(等)養分量，-判定待自容器輸送之原料成分量，其對應於由使用者透過輸入構件請求之養分量，及-控制輸送裝置以將判定量之原料成分從容器輸送至貯器中。 The apparatus can further include or have access to a database that stores the value of the nutrient content of the raw material component present in the container, and wherein the controller is adapted to: - extract the raw material component from the database (equal) nutrient component, - determining the amount of raw material component to be delivered from the container, which corresponds to the nutrient component requested by the user through the input member, and - controlling the delivery device to transport the determined amount of the raw material component from the container to the reservoir .
設備可進一步包括或存取：-儲存依據嬰兒之健康參數之養分之推薦攝取值之資料庫，-儲存存在於容器中之原料成分之(諸)養分含量之值的資料庫，其中：-有關待自設備輸送之一或多個原料成分量之來自使用者之輸入係嬰兒之健康參數，-輸送裝置經調適以從資料庫擷取對應於健康參數輸入之養分之推薦攝取值並相應地判定待自容器輸送之一者或多者之原料成分量。 The apparatus may further comprise or access: - a database storing recommended intake values of nutrients based on the health parameters of the infant, - a database storing the value of the nutrient content of the raw material components present in the container, wherein: - The health parameter of the input baby from the user of one or more raw material components to be delivered from the device, the delivery device is adapted to retrieve the recommended intake value of the nutrient corresponding to the health parameter input from the database and determine accordingly The amount of the raw material component to be delivered from one or more of the containers.
在本發明之一實施例中，營養組合物係嬰兒配方奶粉、初生嬰 兒配方奶粉、較大嬰兒配方奶粉、嬰兒穀物組合物、強化奶(諸如人類母乳或動物奶)、強化嬰兒配方奶粉或營養補充劑(諸如奶，諸如人類母乳或動物奶，例如牛奶之補充劑或習知嬰兒配方奶粉之補充劑)，亦被稱作營養強化劑。 In one embodiment of the invention, the nutritional composition is an infant formula, a newborn baby Formula, larger infant formula, infant cereal composition, fortified milk (such as human breast milk or animal milk), fortified infant formula or nutritional supplements (such as milk, such as human breast milk or animal milk, such as milk supplements) Or a supplement of a known infant formula, also known as a nutritional enhancer.
在特定實施例中，營養組合物係嬰兒配方奶粉。 In a particular embodiment, the nutritional composition is an infant formula.
容器較佳係單次使用容器。 The container is preferably a single use container.
設備較佳可包括消毒構件以在設備內維持無菌條件及較佳包括構件，諸如用於使設備內部暴露於UV光之臭氧源及/或照明構件。設備較佳亦可包括機殼(即圍繞設備之密封外殼)以防止污染物進入設備內。 The apparatus preferably includes a sterilization member to maintain sterile conditions within the apparatus and preferably includes components such as an ozone source and/or illumination member for exposing the interior of the apparatus to UV light. Preferably, the device may also include a housing (i.e., a sealed enclosure surrounding the device) to prevent contaminants from entering the device.
設備較佳可將被計量原料成分輸送至貯器中，較佳用於管餵食之囊、餵食瓶/奶瓶或注射器。 Preferably, the device delivers the metered ingredients to the reservoir, preferably for tube feeding, feeding bottles/bottles or syringes.
輸送裝置之一者或多者較佳可包括用於計量原料成分(通常為液體或粉末)之計量泵。 One or more of the delivery devices preferably may include a metering pump for metering the ingredients of the material, typically a liquid or powder.
在一些實施例中，原料成分之至少一部分(或其等之所有)為液體。在一些其他實施例中，存在液體及粉末原料成分。 In some embodiments, at least a portion of the feedstock component (or all of it, etc.) is a liquid. In some other embodiments, liquid and powder feedstock components are present.
在一些其他實施例中，原料成分係粉末。 In some other embodiments, the raw material component is a powder.
輸送裝置之一者或多者較佳可包括計量裝置，諸如螺旋餵食器、擠出器、氣體驅動液化器，其通常用於計量固體物質，諸如粉末。 One or more of the delivery devices may preferably include metering devices such as screw feeders, extruders, gas driven liquezers, which are typically used to meter solid materials, such as powders.
設備舉例而言可包括用於對複數個容器之一者或多者稱重之稱重單元。 The apparatus may, for example, include a weighing unit for weighing one or more of the plurality of containers.
設備較佳可包括用於混合所輸送原料成分之混合裝置。 Preferably, the apparatus can include a mixing device for mixing the components of the delivered material.
在一些實施例中，營養組合物將為粉末。 In some embodiments, the nutritional composition will be a powder.
在一些實施例中，營養組合物將為液體。實際上，設備可包括液化裝置，諸如液體源及混合器以提供組合物為液體或液化物質。 In some embodiments, the nutritional composition will be a liquid. In practice, the apparatus can include a liquefaction device, such as a liquid source and a mixer to provide the composition as a liquid or liquefied material.
設備可進一步包括或存取用於分析組合物(例如，奶)中之養分量之分析器(例如，奶分析裝置)或經調適以接收組合物(例如，奶)中之養分量之值且其中設備經調適以基於表示將輸送之一或多個原料成分及組合物(例如，奶)中之實際養分之來自使用者之輸入判定將輸送之原料成分量。分析器可為奶分析器，諸如人類母乳或替代物。 The apparatus can further include or access an analyzer (eg, a milk analysis device) for analyzing nutrients in the composition (eg, milk) or adapted to receive a value of the nutrient component of the composition (eg, milk) and Wherein the apparatus is adapted to determine the amount of ingredient to be delivered based on input from the user indicating that the actual nutrient in one or more of the ingredients and compositions (eg, milk) will be delivered. The analyzer can be a milk analyzer, such as human breast milk or a substitute.
設備可進一步包括或存取資料庫，該資料庫儲存嬰兒養分之推薦最大及/或最小攝取值之法定及/或科學資料。 The device may further include or access a database that stores statutory and/or scientific information on the recommended maximum and/or minimum intake of infant nutrients.
設備可進一步包括或存取資料庫，該資料庫儲存養分之不相容資料。 The device can further include or access a database that stores incompatible information for the nutrient.
設備可進一步包括或存取資料庫，該資料庫儲存先前用由根據本發明之設備產生之組合物或普通組合物餵食之嬰兒之反應資料。 The device may further comprise or access a database storing reaction data of infants previously fed with the composition or common composition produced by the device according to the invention.
較佳，原料成分選自包括初乳、預製補充組合物、嬰兒配方奶粉、人奶強化劑、早產兒配方奶粉、嬰兒配方奶粉、水及包括一或多個養分之組合物之群組。 Preferably, the raw material component is selected from the group consisting of colostrum, pre-formed supplement, infant formula, human milk fortifier, pre-term formula, infant formula, water, and a composition comprising one or more nutrients.
較佳，一或多個養分選自蛋白質、類脂物、碳水化合物、維他命、礦物質、核苷酸、益生菌、益菌助生質、奶寡糖、生長因子、奶成分、抗氧化劑之群組。 Preferably, the one or more nutrients are selected from the group consisting of proteins, lipids, carbohydrates, vitamins, minerals, nucleotides, probiotics, probiotics, milk oligosaccharides, growth factors, milk components, antioxidants group.
較佳根據最終產品之所要體積輸入組合物之體積及判定原料成分量。 Preferably, the volume of the composition is input according to the desired volume of the final product and the amount of the raw material component is determined.
本發明之另一態樣係關於一種製備將餵飼嬰兒之營養組合物之方法，其中該組合物針對特定嬰兒定製且其中該方法從養分之推薦攝取值及/或特定嬰兒之健康參數判定將存在於組合物中之個別原料成分量。 Another aspect of the invention relates to a method of preparing a nutritional composition for feeding an infant, wherein the composition is tailored to a particular infant and wherein the method is determined from a recommended intake of nutrients and/or a health parameter of a particular infant. The amount of individual raw ingredients that will be present in the composition.
較佳，方法藉由使用電腦而執行。 Preferably, the method is performed by using a computer.
較佳，該所製備營養組合物進一步針對特定餵飼，諸如腸道餵飼而定製。 Preferably, the prepared nutritional composition is further tailored to a particular feed, such as enteral feeding.
通常，本發明之不同態樣可以本發明之範疇內可行之任意方式組合及結合。本發明之此等及其他態樣、特徵及/或優點將參考下文所述之實施例瞭解及闡明。 In general, the various aspects of the invention may be combined and combined in any manner that is within the scope of the invention. These and other aspects, features and/or advantages of the present invention will be understood and elucidated with reference to the embodiments described herein.
現將更詳細描述本發明。 The invention will now be described in more detail.
1‧‧‧設備 1‧‧‧ Equipment
2‧‧‧容器 2‧‧‧ Container
3‧‧‧輸送裝置 3‧‧‧Conveyor
4‧‧‧貯器 4‧‧‧Storage
5‧‧‧計量裝置 5‧‧‧Measuring device
6‧‧‧資料庫 6‧‧‧Database
7‧‧‧控制器 7‧‧‧ Controller
10‧‧‧機殼 10‧‧‧Chassis
11‧‧‧容座 11‧‧‧ 容座
12‧‧‧漏斗狀收集器 12‧‧‧Funnel Collector
13‧‧‧管道 13‧‧‧ Pipes
14‧‧‧輸入構件 14‧‧‧ Input components
15‧‧‧口部 15‧‧‧ mouth
本發明之額外特徵及優點描述於下文參考附圖說明之目前較佳實施例之描述並將從中瞭解，其中：圖1示意繪示根據本發明之第一實施例之提供被計量原料成分至用於餵飼嬰兒諸如用於腸道餵飼之營養組合物之設備。 The additional features and advantages of the present invention are described and will be understood from the following description of the preferred embodiments illustrated in the accompanying drawings in which: FIG. 1 schematically illustrates the provision of the measured raw material components in accordance with the first embodiment of the present invention. An apparatus for feeding an infant, such as a nutritional composition for enteral feeding.
定義： definition:
在進一步詳細討論本發明之前，下列術語及慣例將首先定義。 Before discussing the invention in further detail, the following terms and conventions will be defined first.
除非另有定義，否則本文使用之所有技術及科學術語具有如本領域一般技術者所普遍瞭解之相同含義。 All technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art, unless otherwise defined.
在本發明之背景中，術語「嬰兒」將意指2歲以下之幼兒，較佳不足12個月之嬰兒，諸如不足9個月、尤其不足6個月。 In the context of the present invention, the term "infant" will mean a child under 2 years of age, preferably an infant of less than 12 months, such as less than 9 months, especially less than 6 months.
在本發明之背景中，嬰兒可為任意足月兒或早產兒。本發明之一實施例中，嬰兒係早產兒。 In the context of the present invention, the infant can be any term or premature infant. In one embodiment of the invention, the infant is a premature infant.
術語「足月兒」指的是在足月或懷孕37周或更長時間後出生之嬰兒。 The term "term infant" refers to an infant born at full term or 37 weeks or more of pregnancy.
術語「早產兒」指的是在懷孕第37周前出生之嬰兒。 The term "premature baby" refers to an infant born before the 37th week of pregnancy.
如本文中所使用之術語「嬰兒配方奶粉」指的是用於餵養嬰兒之營養組合物。 The term "infant formula" as used herein refers to a nutritional composition for feeding an infant.
藉由術語「強化劑」意指用於強化或補充奶，例如人類母乳或嬰兒配方奶粉之任意組合物。強化劑亦可被稱作補充組合物且該等術語可交換使用。強化劑指的是包括對嬰兒(早產兒及足月兒兩者)具有 營養好處之一或多個養分之組合物。強化組合物或補充組合物可為包括高數量之養分，諸如類脂物、蛋白質、碳水化合物、礦物質、維他命、益生菌或益菌助生質之組合物。 By the term "enhancing agent" is meant any composition for fortifying or replenishing milk, such as human breast milk or infant formula. Enhancers may also be referred to as supplemental compositions and the terms are used interchangeably. Fortifiers are meant to include for infants (both premature and term) One or more nutrient combinations of nutritional benefits. The fortifying or supplemental composition can be a composition comprising a high amount of nutrients, such as lipids, proteins, carbohydrates, minerals, vitamins, probiotics or probiotics.
在本發明之背景中，術語「養分」指的是對身體具有有益效應例如以提供能量或所需生長之化合物。養分之實例係蛋白質、碳水化合物、類脂物、維他命及礦物質、核苷酸、益生菌、益菌助生質、奶寡糖、生長因子、奶成分、抗氧化劑。 In the context of the present invention, the term "nutrient" refers to a compound that has a beneficial effect on the body, for example to provide energy or desired growth. Examples of nutrients are proteins, carbohydrates, lipids, vitamins and minerals, nucleotides, probiotics, probiotics, milk oligosaccharides, growth factors, milk ingredients, antioxidants.
術語「原料成分」指的是可含有一或多個養分之組合物且其係存在於設備之容器中並混合以形成嬰兒之營養組合物之原料成分。原料成分亦可被稱作養分源。 The term "raw ingredient" refers to a composition that can contain one or more nutrients and which is present in a container of the device and mixed to form a nutritional composition of the infant. The raw material component can also be referred to as a nutrient source.
舉例而言，原料成分本身可為養分，例如，酪蛋白及乳清蛋白之乳糖粉末或蛋白質粉末。但是，原料成分亦可為不同養分之混合物，諸如包括類脂物、乳化劑、穩定劑及維他命之乳狀液。原料成分之另一實例係奶粉，其包括蛋白質、碳水化合物、類脂物、維他命及礦物質。原料成分之另一實例係強化組合物，舉例而言，包括蛋白質、碳水化合物、類脂物、維他命及礦物質以及乳化劑及穩定劑之強化劑。此等強化組合物可以許多不同形式獲得且不同養分之數量可隨強化組合物而不同。原料成分之另一實例可為嬰兒配方奶粉，諸如針對足月兒、針對早產兒、針對低出生體重嬰兒及學步幼兒之嬰兒配方奶粉。 For example, the raw material component itself may be a nutrient such as lactose powder or protein powder of casein and whey protein. However, the raw material ingredients may also be a mixture of different nutrients, such as emulsions including lipids, emulsifiers, stabilizers, and vitamins. Another example of a raw material ingredient is milk powder, which includes proteins, carbohydrates, lipids, vitamins and minerals. Another example of a raw material component is a fortifying composition including, for example, proteins, carbohydrates, lipids, vitamins and minerals, and enhancers of emulsifiers and stabilizers. These reinforced compositions can be obtained in many different forms and the amount of different nutrients can vary with the reinforced composition. Another example of a raw ingredient may be an infant formula such as infant formula for term infants, for premature infants, for low birth weight infants and toddlers.
本發明之一實施例中，原料成分選自包括初乳、預製補充組合物、嬰兒配方奶粉、人奶強化劑、早產兒配方奶粉、嬰兒配方奶粉、水及包括一或多個養分之組合物之群組。 In one embodiment of the invention, the raw material component is selected from the group consisting of colostrum, pre-formed supplement composition, infant formula, human milk fortifier, preterm formula milk powder, infant formula, water, and a composition comprising one or more nutrients Group of.
當使用「提供被計量原料成分至用於餵飼嬰兒之營養組合物」之措詞時，此涵蓋： When using the phrase "providing the ingredients of the measured ingredients to the nutritional composition used to feed the baby", this covers:
-添加被計量原料成分至現有營養組合物，諸如舉例而言添加強 化劑至人奶，隨後將最終營養組合物餵飼嬰兒。 Adding the metered ingredients to the existing nutritional composition, such as for example adding strong The agent is applied to human milk, and the final nutritional composition is then fed to the infant.
-及/或藉由混合被計量原料成分而製備營養組合物，隨後將該營養組合物餵飼嬰兒。 - and/or preparing a nutritional composition by mixing the metered ingredients, which are then fed to the infant.
藉由「嬰兒之健康參數」之措詞，其意指有關嬰兒之參數，諸如身體、生理或出生相關資料，其實現嬰兒之營養需求之判定且具有營養組合物之組成率。一些非限制性實例包含體重、身長、頭圍、孕齡(出生年齡)、矯正年齡(根據出生年齡矯正的出生後周或月數)、產後年齡(即，嬰兒之出生後年齡或實齡)、嬰兒早產時間(即，嬰兒之成熟程度或早產年齡)、食物攝取歷史(即，嬰兒近幾日之食物攝取)、體重增加歷史、發育停滯、血液或尿液分析(BUN、鈣、磷...)。 By the wording "infant health parameters", it is meant a parameter relating to an infant, such as physical, physiological or birth-related information, which determines the nutritional needs of the infant and has a compositional rate of the nutritional composition. Some non-limiting examples include body weight, length, head circumference, gestational age (birth age), corrected age (post-natal week or month corrected for birth age), postpartum age (ie, infant's postnatal age or age) , baby premature birth time (ie, maturity or premature birth age), food intake history (ie, infant food intake in recent days), weight gain history, developmental stagnation, blood or urine analysis (BUN, calcium, phosphorus. ..).
來自使用者之輸入可為選自包括體重、身長、頭圍、孕齡、矯正年齡、出生後年齡、嬰兒早產時間、食物攝取歷史、體重增加歷史、發育停滯、血液或尿液分析(BUN、鈣、磷...)及其等之任意組合之列表之嬰兒之健康參數。 Inputs from the user may be selected from the group consisting of body weight, length, head circumference, gestational age, corrected age, postnatal age, preterm birth time, food intake history, weight gain history, developmental stagnation, blood or urine analysis (BUN, Health parameters of infants in the list of calcium, phosphorus, and any combination thereof.
來自使用者之輸入可為選自包括身長、頭圍、孕齡、矯正年齡、出生後年齡、嬰兒早產時間、食物攝取歷史、體重增加歷史、發育停滯、血液或尿液分析(BUN、鈣、磷...)及其等之任意組合之列表之嬰兒之健康參數。 Inputs from the user may be selected from the group consisting of body length, head circumference, gestational age, corrected age, postnatal age, preterm birth time, food intake history, weight gain history, developmental stagnation, blood or urine analysis (BUN, calcium, Health parameters of infants in the list of phosphorus...) and any combination thereof.
在一些實施例中，來自使用者之輸入係嬰兒之至少兩個、三個、四個、五個或六個健康參數之組合，諸如選自包括體重、身長、頭圍、孕齡、矯正年齡、出生後年齡、嬰兒早產時間、食物攝取歷史、體重增加歷史、發育停滯、血液或尿液分析(BUN、鈣、磷...)之列表之健康參數。 In some embodiments, the input from the user is a combination of at least two, three, four, five or six health parameters of the infant, such as selected from the group consisting of body weight, length, head circumference, gestational age, corrected age. Health parameters, list of postnatal age, preterm birth time, food intake history, weight gain history, developmental stagnation, blood or urine analysis (BUN, calcium, phosphorus...).
在一些實施例中，來自使用者之輸入係嬰兒之至少兩個、三個、四個、五個或六個健康參數之組合，諸如選自包括身長、頭圍、孕齡、矯正年齡、出生後年齡、嬰兒早產時間、食物攝取歷史、體重 增加歷史、發育停滯、血液或尿液分析(BUN、鈣、磷...)之列表之健康參數。 In some embodiments, the input from the user is a combination of at least two, three, four, five or six health parameters of the infant, such as selected from the group consisting of body length, head circumference, gestational age, corrected age, birth Post-age, infant premature birth time, food intake history, weight Increase health parameters for history, developmental stagnation, blood or urine analysis (BUN, calcium, phosphorus...).
在一些實施例中，來自使用者之輸入係嬰兒之體重及可選自上述列表之至少另一健康參數。 In some embodiments, the input from the user is the weight of the infant and may be selected from at least one other health parameter of the above list.
在一些實施例中，來自使用者之輸入係嬰兒之身長及可選自上述列表之至少另一健康參數。 In some embodiments, the input from the user is the length of the infant and may be selected from at least one other health parameter of the above list.
在一些實施例中，來自使用者之輸入係嬰兒年齡(孕齡、矯正年齡、出生後年齡及/或嬰兒早產時間)及可選自上述列表之至少另一健康參數。 In some embodiments, the input from the user is the infant age (gestational age, corrected age, postnatal age, and/or infant premature birth time) and may be selected from at least one other health parameter of the above list.
在一些實施例中，來自使用者之輸入係食物攝取歷史及可選自上述列表之至少另一健康參數。 In some embodiments, the input from the user is a food intake history and may be selected from at least one other health parameter of the above list.
在一些實施例中，來自使用者之輸入係體重增加歷史及可選自上述列表之至少另一健康參數。 In some embodiments, the input from the user is a history of weight gain and may be selected from at least one other health parameter of the above list.
在一些實施例中，來自使用者之輸入係發育停滯及可選自上述列表之至少另一健康參數。 In some embodiments, the input from the user is stagnant and may be selected from at least one other health parameter of the above list.
在一些實施例中，來自使用者之輸入係血液或尿液分析(BUN、鈣、磷...)及可選自上述列表之至少另一健康參數。 In some embodiments, the input from the user is blood or urine analysis (BUN, calcium, phosphorus, ...) and may be selected from at least one other health parameter of the above list.
在一些實施例中，來自使用者之輸入係或至少係嬰兒之體重及身長。 In some embodiments, the input from the user or at least the weight and length of the infant.
在一些實施例中，來自使用者之輸入係或至少係嬰兒之體重、身長及頭圍。 In some embodiments, the input from the user or at least the weight, length and head circumference of the infant.
在一些實施例中，來自使用者之輸入係或至少係嬰兒之體重、身長、頭圍及出生後年齡。 In some embodiments, the input from the user or at least the weight, length, head circumference and postnatal age of the infant.
在一些實施例中，來自使用者之輸入係或至少係嬰兒之體重、身長、頭圍、出生後年齡及嬰兒早產時間。 In some embodiments, the input from the user or at least the infant's weight, length, head circumference, postnatal age, and infant preterm birth time.
在一些實施例中，來自使用者之輸入係或至少係嬰兒之體重、 身長及出生後年齡。 In some embodiments, the input from the user or at least the weight of the baby, Length and age after birth.
在一些實施例中，來自使用者之輸入係或至少係嬰兒之體重、身長及嬰兒早產時間。 In some embodiments, the input from the user or at least the weight, length, and infant premature time of the infant.
在一些實施例中，來自使用者輸入係或至少係嬰兒之體重、身長、出生後年齡及嬰兒早產時間。 In some embodiments, the user input system or at least the infant's weight, length, postnatal age, and infant preterm birth time.
在特定實施例中，來自使用者之輸入非或不僅係嬰兒之體重。 In a particular embodiment, the input from the user is not or not only the weight of the infant.
原料成分之(諸)養分含量之「值」對應於原料成分中之(諸)養分量。值將取決於嬰兒需求調適。養分之推薦攝取值為熟練技工所知，此係因為其等可由法律規定及/或由有資質之專家(例如，Espghan營養委員會)提供。值之一些實例可見C.Agostoni等人，「Enteral Nutrient Supply for Preterm Infants: Commentary From the European Society for Paediatric Gastroenterology, Hepatology, and Nutrition Committee on Nutrition」，JPGN，第50卷、第1號，2010年1月。推薦值將取決於嬰兒之健康參數而變化。 The "value" of the nutrient content of the raw material component corresponds to the nutrient component(s) in the raw material component. The value will depend on the baby's needs. The recommended intake of nutrients is known to the skilled worker as it may be provided by law and/or by a qualified expert (eg, the Espghan Nutrition Committee). Some examples of values can be found in C. Agostoni et al., "Enteral Nutrient Supply for Preterm Infants: Commentary From the European Society for Paediatric Gastroenterology, Hepatology, and Nutrition Committee on Nutrition", JPGN, Vol. 50, No. 1, 2010 1 month. The recommended value will vary depending on the baby's health parameters.
現將參考附圖更詳細描述本描述。 The description will now be described in more detail with reference to the accompanying drawings.
參考圖1，其示意繪示用於提供被計量原料成分至用於餵飼嬰兒之營養組合物之設備1。營養組合物較佳係嬰兒配方奶粉、初生嬰兒配方奶粉、較大嬰兒配方奶粉、嬰兒穀物組合物、強化奶、諸如強化人奶或動物奶、強化嬰兒配方奶粉或營養補充劑。 Referring to Figure 1, there is schematically illustrated an apparatus 1 for providing a metered stock ingredient to a nutritional composition for feeding an infant. The nutritional composition is preferably an infant formula, a newborn infant formula, a larger infant formula, an infant cereal composition, a fortified milk, such as fortified human milk or animal milk, a fortified infant formula or a nutritional supplement.
如本文所述，來自設備之輸出係被計量原料成分且數量被計量使得其等單獨或結合其他原料成分諸如母乳提供針對特定嬰兒定製之營養組合物。雖然本發明之範疇不限於用於腸道餵飼(即，口服或藉由管餵食)之組合物，但是此餵飼已被證實有價值。 As described herein, the output from the device is metered into the ingredients and the amount is metered such that they provide a nutritional composition tailored to a particular infant, either alone or in combination with other ingredients, such as breast milk. While the scope of the invention is not limited to compositions for enteral feeding (i.e., oral or by tube feeding), this feeding has proven to be of value.
如圖1所示，設備包括複數個容器2，各容器2容納營養組合物之一或多個原料成分。容器2通常係在容器充滿一或多種特定原料成分且較佳在工廠密封之意義上之拋棄式容器，但是，可再填充容器2亦 可以原料成分例如從囊或用於裝運目的之類似封裝倒入容器之方式使用。密封要求通常根據有關將特定原料成分與環境密封開之所要需求選擇。密封以普通方式提供，例如藉由焊接至容器之蓋且以尋求防止容器之再填充以避免非所要之污染。因此，容器2係單次使用容器。在許多較佳實施例中，密封係可由刀子或類似尖銳工具刺穿之塑膠片。 As shown in Figure 1, the apparatus includes a plurality of containers 2, each container 2 containing one or more of the ingredients of the nutritional composition. The container 2 is typically a disposable container in the sense that the container is filled with one or more specific ingredients and is preferably sealed in a factory, but the refillable container 2 is also The raw material ingredients can be used, for example, from a pouch or similar package for shipping purposes. Sealing requirements are typically selected based on the desired requirements for sealing a particular feedstock component to the environment. The seal is provided in a conventional manner, for example by welding to the lid of the container and seeking to prevent refilling of the container to avoid undesired contamination. Therefore, the container 2 is a single use container. In many preferred embodiments, the seal is a plastic sheet that can be pierced by a knife or similar sharp tool.
設備進一步包括複數個輸送裝置3。輸送裝置之各者連接至容器2且經調適以從容器2輸送被計量之容器2中所容納之一或多個原料成分，該一或多個原料成分將形成組合物之部分。 The device further comprises a plurality of conveying devices 3. Each of the delivery devices is coupled to the container 2 and adapted to deliver one or more of the raw material components contained in the metered container 2 from the container 2, the one or more raw material components will form part of the composition.
雖然圖1所示之較佳實施例包括用於各容器2之輸送裝置3，但是單個輸送裝置3可應用於單個輸送裝置3經調適以個別連接至單個容器2之情況中。一此實施方案可為具有貯器之傳送帶。傳送帶可以受控方式旋轉使得貯器可藉由傳送帶之旋轉而放置在所選容器2下方。一旦貯器放置在所選容器2下方，控制器7即控制調節容器之流出之斷流閥打開使得原料成分被配給至貯器中。原料成分流出容器2視需要藉由振動容器2以鬆開例如容器2中之粉末物質輔助而藉由重力提供。原料成分量可由斷流閥之打開時間判定及/或經配置以對貯器及其內容物稱重之稱重單元判定。 Although the preferred embodiment illustrated in Figure 1 includes a delivery device 3 for each container 2, a single delivery device 3 can be utilized in the context of a single delivery device 3 being adapted for individual attachment to a single container 2. One such embodiment may be a conveyor belt having a receptacle. The conveyor belt can be rotated in a controlled manner such that the receptacle can be placed beneath the selected container 2 by rotation of the conveyor belt. Once the reservoir is placed below the selected container 2, the controller 7 controls the shut-off valve that regulates the outflow of the container to open so that the stock components are dispensed into the reservoir. The raw material component outflow container 2 is supplied by gravity as needed by vibrating the container 2 to release, for example, the powder substance in the container 2. The amount of ingredient component can be determined by the opening time of the shutoff valve and/or by a weighing unit configured to weigh the reservoir and its contents.
輸送裝置3輸送被計量原料成分至貯器4。在圖1之較佳實施例中，輸送裝置3包括容座11，容器2以密封接合裝配在該容座11中。容座11通常包括尖銳元件(未繪示)，其在容器2被配置在容座11中時破開容器2之密封。輸送裝置3進一步包括管13，其在一末梢端上開放至容座11中以接收來自容器2之原料成分且另一末梢端開放至漏斗狀收集器12中。漏斗狀收集器包括蓋(未繪示)以避免攜帶污染。流動穿過管13之原料成分量由包括在輸送裝置3中之計量裝置5判定。 The conveying device 3 conveys the metered raw material components to the reservoir 4. In the preferred embodiment of Figure 1, the delivery device 3 includes a receptacle 11 in which the container 2 is mounted in a sealing engagement. The receptacle 11 generally includes a sharp element (not shown) that breaks the seal of the container 2 when the container 2 is disposed in the receptacle 11. The delivery device 3 further comprises a tube 13 which is open to the receptacle 11 at a distal end to receive the raw material composition from the container 2 and the other distal end is open into the funnel-shaped collector 12. The funnel-shaped collector includes a cover (not shown) to avoid carrying contamination. The amount of the raw material component flowing through the tube 13 is determined by the metering device 5 included in the conveying device 3.
計量裝置5可為用於計量原料成分之計量泵之形式。此等計量泵 可計量液體以及粉末材料。可結合本發明應用之其他計量裝置5包含螺旋餵食器、擠出器、氣體驅動液化器，其通常用於計量固體物質，諸如粉末。 The metering device 5 can be in the form of a metering pump for metering the ingredients of the raw materials. These metering pumps It can measure liquid as well as powder materials. Other metering devices 5 that may be used in conjunction with the present invention comprise a screw feeder, an extruder, a gas driven liquefier, which is typically used to meter solid materials, such as powders.
作為配置在輸送裝置3中之計量裝置5之替代，稱重單元可經配置以對複數個容器2之一者或多者稱重。重量減小可用於判定自容器2輸送之原料成分量。此等稱重單元亦可結合計量裝置5使用以驗證數量及/或維持有關存在於容器中之原料成分量之記錄，後者可用於傳達容器係空的或接近空的及需要替換。 Instead of the metering device 5 arranged in the transport device 3, the weighing unit can be configured to weigh one or more of the plurality of containers 2. The weight reduction can be used to determine the amount of raw material component delivered from the container 2. These weighing units can also be used in conjunction with metering device 5 to verify the quantity and/or maintain a record of the amount of ingredient present in the container, which can be used to convey that the container is empty or nearly empty and needs to be replaced.
通常，自容器2輸送之原料成分需混合且設備1因此可包括用於混合所輸送原料成分之混合裝置。此一混合裝置可為應用於例如在漏斗狀收集器12中運作使得原料成分在從容器2輸送時混合之攪拌器。但是，此要求原料成分同時從容器2輸送至漏斗狀收集器12，其不一定總是此情況。若原料成分依序輸送，則混合可為振動器振動貯器4。 Typically, the ingredients of the raw materials transported from the container 2 are mixed and the apparatus 1 may thus comprise a mixing device for mixing the ingredients of the delivered raw materials. This mixing device can be a blender that is applied, for example, to operate in the funnel-shaped collector 12 such that the raw material components are mixed as they are transported from the container 2. However, this requires that the raw material ingredients be simultaneously transported from the container 2 to the funnel-shaped collector 12, which is not always the case. If the raw material components are sequentially delivered, the mixing may be the vibrator vibration reservoir 4.
在許多情況中，需要產生即食嬰兒配方奶粉或至少液體產品且在此等情況中，設備包括液化裝置。此一液化裝置可為液體源及混合器以提供組合物為液體或液化物質，且液體源可為含有所需液體之容器2之一者或多者或其可為外部液體源，諸如水。液體可儲存在設備，諸如專用儲存器中。液體可在儲存器中無菌製作或可在供應至混合器時藉由消毒構件，諸如UV光、加熱或臭氧而按需要來消毒。 In many cases, it is desirable to produce ready-to-eat infant formula or at least a liquid product and in such cases the device includes a liquefaction device. The liquefaction device can be a liquid source and a mixer to provide the composition as a liquid or liquefied material, and the liquid source can be one or more of the containers 2 containing the desired liquid or it can be an external source of liquid, such as water. The liquid can be stored in a device, such as a dedicated reservoir. The liquid can be aseptically produced in a reservoir or can be sterilized as needed by a sterile member such as UV light, heat or ozone when supplied to the mixer.
設備亦包括輸入構件14，諸如圖形使用者介面，其經調適以接收有關待自設備1輸送之一或多個原料成分量之來自使用者之輸入。來自使用者之輸入可取決於需求而變化。但是，有關將輸送之一或多個原料成分量之使用者輸入可較佳及有利地為嬰兒之特性、諸如體重、身長、出生後年齡、早產年齡(即，嬰兒早產時間)、頭圍、食物攝取歷史(即，嬰兒近幾日之食物攝取)、體重增加歷史、發育停滯、 血液或尿液分析(BUN、鈣、磷)...等，基於該等特性，嬰兒配方奶粉之營養含量可(例如，藉由查詢儲存在資料庫中之表格)導出。營養含量之此等導出通常由控制器7執行，該控制器7係設備之一部分或設備與此控制器7資料通信。 The device also includes an input member 14, such as a graphical user interface, adapted to receive input from the user regarding the amount of one or more ingredients to be delivered from the device 1. Input from the user can vary depending on the needs. However, user input regarding the amount of one or more ingredients to be delivered may preferably and advantageously be characteristics of the infant, such as body weight, length, age at birth, premature birth (ie, premature delivery time), head circumference, History of food intake (ie, food intake by infants in recent days), history of weight gain, developmental stagnation, Blood or urine analysis (BUN, calcium, phosphorus), etc., based on these characteristics, the nutritional content of the infant formula can be derived (for example, by querying a table stored in a database). Such derivation of the nutrient content is typically performed by a controller 7 that is in communication with the controller 7 as part of the device or device.
一旦判定營養需求，即導出容器中所儲存之不同原料成分量，其等足以滿足營養需求。在其他實施例中，來自使用者之輸入可為不同養分及/或特定數量之將輸送原料成分之需求。 Once the nutritional requirements are determined, the amount of different raw ingredients stored in the container is derived, which is sufficient to meet nutritional needs. In other embodiments, the input from the user may be a requirement for different nutrients and/or a particular amount of material components to be delivered.
控制器7包括在設備中或設備連接至控制器7。控制器7經調適以控制回應於來自使用者之輸入由輸送裝置3從容器個別輸送之被計量原料成分。因此，一旦得到將輸送之原料成分之實際數量，控制器7即控制計量裝置之動作使得此等數量經由管13從容器2移動穿過漏斗狀收集器12並進入貯器4。 The controller 7 is included in the device or the device is connected to the controller 7. The controller 7 is adapted to control the metered feedstock components that are individually delivered from the container by the delivery device 3 in response to input from the user. Thus, once the actual amount of raw material components to be delivered is obtained, the controller 7 controls the action of the metering device such that the quantities move from the container 2 through the funnel-like collector 12 via the tube 13 and into the reservoir 4.
貯器4有利地可為用於管餵食之囊、餵食瓶/奶瓶或注射器。 The reservoir 4 may advantageously be a bladder for feeding a tube, a feeding bottle/feed bottle or a syringe.
容器2中所容納之原料成分通常選自含有對於嬰兒必不可少之養分，諸如蛋白質、類脂物、碳水化合物、維他命及礦物質之組合物。原料成分亦可為包括益生菌、益菌助生質、核苷酸、奶寡糖、初乳、生長因子、奶成分、抗氧化劑或僅僅水之組合物。水(若存在)較佳無菌。原料成分可包括一養分或可為兩個或更多個養分之組合。原料成分亦可為市場上存在之習知嬰兒配方奶粉(早產兒配方奶粉及足月兒配方奶粉)、預製補充組合物或事先用一或多個補充組合物補充之嬰兒配方奶粉。 The ingredients of the ingredients contained in the container 2 are typically selected from compositions containing nutrients essential to the infant, such as proteins, lipids, carbohydrates, vitamins and minerals. The raw ingredient may also be a composition comprising probiotics, probiotics, nucleotides, milk oligosaccharides, colostrum, growth factors, milk ingredients, antioxidants or just water. Water, if present, is preferably sterile. The raw material component may comprise a nutrient or may be a combination of two or more nutrients. The raw material ingredients may also be conventional infant formulas (premature formula and term infant formula), pre-formed supplements or infant formula supplemented with one or more supplemental compositions in advance.
設備1可進一步包括或存取資料庫6，資料庫6儲存存在於容器2中之原料成分之該(等)養分含量之值。當此一資料庫6使用時，待自容器2輸送之實際數量之導出由控制器7執行且包含控制器7由適當軟體指令調適以從資料庫6擷取原料成分中之(諸)養分量。一旦該(等)養分量被控制器7得知，其即判定待自容器2輸送之原料成分量，其對應 於由使用者透過輸入構件14請求之養分量。資料庫可儲存在設備之控制器之記憶體中或可儲存在可經由通信網路存取之遠端伺服器中。在遠端資料擷取系統之情况中，設備包括通信模組(例如，wifi、數據處理機、乙太網路...)，使其能與外部網路交換資料。 The device 1 may further comprise or access a database 6 that stores the value of the (etc.) nutrient content of the ingredients of the ingredients present in the container 2. When such a database 6 is used, the actual amount of delivery to be delivered from the container 2 is performed by the controller 7 and the controller 7 is adapted by appropriate software instructions to retrieve the component(s) from the material component 6 from the database 6 . Once the (equal) nutrient component is known by the controller 7, it determines the amount of the raw material component to be delivered from the container 2, which corresponds to The nutrient component requested by the user through the input member 14. The database can be stored in the memory of the device's controller or can be stored in a remote server accessible via the communication network. In the case of a remote data retrieval system, the device includes a communication module (eg, wifi, data processor, Ethernet...) to enable it to exchange data with an external network.
應注意在許多實例中，使用者之輸入非養分請求而是特定嬰兒之特性，其直接構成養分請求。在此等情况中，控制器7例如藉由依據輸入特性查詢儲存養分值之資料庫而將特性輸入轉換為養分含量。 It should be noted that in many instances, the user inputs a non-nutrient request but a characteristic of a particular infant that directly constitutes a nutrient request. In such cases, the controller 7 converts the characteristic input to a nutrient content, for example, by querying a database storing nutrient values based on the input characteristics.
基於所判定之原料成分量，控制器7控制輸送裝置3以從容器2輸送所判定原料成分量至貯器4中。 Based on the determined amount of raw material components, the controller 7 controls the conveying device 3 to convey the determined raw material component amount from the container 2 to the reservoir 4.
因此，控制器7通常係與儲存資料及指令之記憶體協作之可程式化處理器。 Thus, controller 7 is typically a programmable processor that cooperates with memory that stores data and instructions.
作為用於判定原料成分量之資料庫查找之替代，判定係基於有關輸入與輸送量之間之對應之一組公式。在此情况中，處理器進一步包括用於基於表示一或多個原料成分量之來自使用者之輸入計算待自容器2輸送之原料成分量之演算法。 As an alternative to the database search for determining the amount of the raw material component, the determination is based on a set of formulas relating to the correspondence between the input and the delivery amount. In this case, the processor further includes an algorithm for calculating the amount of the raw material component to be delivered from the container 2 based on input from the user indicating the amount of one or more raw material components.
如上所述，設備1可包括或存取資料庫6。此一資料庫6較佳儲存依據旨在攝取營養組合物之嬰兒之健康參數之養分之推薦攝取值作為記錄，諸如體重、身長、頭圍、出生後年齡(即，出生後之年齡)、早產年齡(即，成熟程度或嬰兒早產時間)。 As mentioned above, the device 1 can include or access the database 6. This database 6 preferably stores records of recommended intake values based on nutrients of the health parameters of the infants who are ingesting the nutritional composition, such as body weight, body length, head circumference, postnatal age (ie, age after birth), preterm birth Age (ie, maturity or time of preterm birth).
如上所述，來自使用者之輸入可為選自包括體重、身長、頭圍、實齡、矯正年齡、出生後年齡、嬰兒早產時間、食物攝取歷史、體重增加歷史、發育停滯、血液或尿液分析(BUN、鈣、磷...)及其等之任意組合之列表之嬰兒之健康參數。 As noted above, the input from the user can be selected from the group consisting of body weight, length, head circumference, age, corrected age, postnatal age, preterm birth time, food intake history, weight gain history, developmental stagnation, blood or urine. Analyze the health parameters of infants in the list (BUN, Calcium, Phosphorus...) and any combination thereof.
包含在該資料庫6或實施為單獨資料庫係存在於容器2中之原料成分之(諸)養分含量之儲存值。此(等)資料庫6通常用於本發明之設置，其中有關待自設備1輸送之一或多個原料成分量之來自使用者之 輸入係嬰兒之健康參數且輸送裝置3經調適以從資料庫6擷取對應於健康參數輸入之養分之推薦攝取值及相應地判定將從容器2之一者或多者輸送之原料成分量。 The stored value of the nutrient content of the raw material component contained in the database 6 or implemented as a separate database in the container 2. This (etc.) database 6 is typically used in the arrangement of the present invention, wherein the amount of one or more raw material components to be delivered from the device 1 is from the user. The health parameters of the infant are entered and the delivery device 3 is adapted to retrieve the recommended intake value of the nutrient corresponding to the health parameter input from the database 6 and to determine the amount of the raw material component to be delivered from one or more of the containers 2 accordingly.
作為簡化實例(E1)，來自使用者之輸入為下列健康參數：嬰兒體重=2.000 kg As a simplified example (E1), the input from the user is the following health parameters: infant weight = 2.000 kg
嬰兒身長=35 cm Baby length = 35 cm
嬰兒實齡=5周 Baby age = 5 weeks
嬰兒早產時間=8周 Baby premature delivery time = 8 weeks
另一實例(E2)可為：嬰兒體重=1.000 kg Another example (E2) can be: infant weight = 1.000 kg
嬰兒身長=35 cm Baby length = 35 cm
孕齡(出生時)=24周 Gestational age (at birth) = 24 weeks
矯正年齡=26周 Correction age = 26 weeks
嬰兒實齡=2周 Baby age = 2 weeks
嬰兒早產時間=16周 Baby premature delivery time = 16 weeks
另一實例(E3)可為：嬰兒體重=1.700 kg Another example (E3) can be: infant weight = 1.700 kg
嬰兒身長=42 cm Baby length = 42 cm
孕齡(出生時)=30周 Gestational age (at birth) = 30 weeks
嬰兒實齡=2周 Baby age = 2 weeks
矯正年齡=32周 Correction age = 32 weeks
嬰兒早產時間=10周 Baby premature delivery time = 10 weeks
「實齡」指的是嬰兒出生後之年齡，即出生後年齡。 "Real age" refers to the age at birth of a baby, that is, the age after birth.
「嬰兒早產時間」指的是嬰兒在足月期之前出生之時間周期，例如，天或周數，例如，嬰兒可在預期足月8周前出生。 "Baby preterm birth time" refers to the period of time during which an infant is born before the term, for example, days or weeks. For example, an infant can be born 8 weeks before the expected full term.
基於舉例而言，實例E1，控制器7從資料庫作出第一判定步驟， 導致組合物之營養含量應為：組份A=1 mg By way of example, for example E1, controller 7 makes a first decision step from the database, The nutrient content of the composition should be: component A = 1 mg
組份B=1.3 mg Component B = 1.3 mg
組份C=11.3 mg Component C=11.3 mg
控制器7從第二資料庫作出有關容器2中所容納之原料成分之營養含量之第二判定步驟：容器I=0.01 mg組份A/mg原料成分 The controller 7 makes a second determination step from the second database regarding the nutrient content of the raw material components contained in the container 2: container I = 0.01 mg component A / mg raw material component
容器II=0.03 mg組份B/mg原料成分 Container II=0.03 mg component B/mg raw material composition
容器III=0.5 mg組份C/mg原料成分 Container III = 0.5 mg component C / mg raw material composition
且在第三判定步驟中，控制器7基於待自各容器2輸送之各原料成分量計算：來自容器I=1/0.01=100.00 mg And in the third determining step, the controller 7 calculates based on the amount of each raw material component to be delivered from each container 2: from the container I = 1 / 0.01 = 100.00 mg
來自容器II=1.3/0.03=43.33 mg From container II=1.3/0.03=43.33 mg
來自容器III=11.3/0.5=22.6 mg From container III=11.3/0.5=22.6 mg
當然，第一判定步驟及第二判定步驟或第二步驟及第三步驟理論上可由控制器在單個步驟中執行。 Of course, the first decision step and the second decision step or the second step and the third step can theoretically be performed by the controller in a single step.
一旦此等值已判定，具有計量裝置5之輸送裝置3被控制使得自容器2輸送此等量。 Once this value has been determined, the delivery device 3 with the metering device 5 is controlled such that this amount is delivered from the container 2.
在特定較佳實施例中，使用者之輸入此外包括營養組合物之體積。舉例而言，營養組合物之體積對應於將強化之人奶之體積。原料成分量可根據營養組合物之體積及/或最終產品之所要體積判定。 In a particularly preferred embodiment, the user's input further includes the volume of the nutritional composition. For example, the volume of the nutritional composition corresponds to the volume of human milk that will be fortified. The amount of the raw material component can be determined based on the volume of the nutritional composition and/or the desired volume of the final product.
嬰兒每天可攝食之體積受限制。假設嬰兒能夠攝取介於96與200 ml流體/kg/天，較佳150至180 ml/kg/天。 The size of the baby's daily intake is limited. It is assumed that the infant is capable of ingesting between 96 and 200 ml fluid/kg/day, preferably 150 to 180 ml/kg/day.
通常，原料成分被例如細菌污染係嚴重問題且應避免。此特別重要，因為營養組合物係用於餵飼嬰兒(其特別敏感(尤其因為其等免疫系統未完全形成，對於早產兒更係如此))且需要特別注意。因此， 根據本發明之設備1可進一步包括以液密方式囊封設備1之內部以在設備1內維持無菌條件之機殼10。機殼10可由允許防止污染物進入設備內之任意其他適當構件替換。此在製備根據本發明之營養組合物時特別重要，此係因為其等旨在餵飼嬰兒。設備1之內部通常係(或含有)容器2、輸送裝置3及漏斗狀收集器12。藉此，僅至容器2內部之開口穿過漏斗狀收集器12之口部15，該口部由亦由控制器7控制之閥門(未繪示)密封。 In general, contamination of raw material components by, for example, bacteria is a serious problem and should be avoided. This is particularly important because the nutritional composition is used to feed infants (which are particularly sensitive (especially because their immune systems are not fully formed, especially for premature infants)) and require special attention. therefore, The device 1 according to the invention may further comprise a casing 10 that encloses the interior of the device 1 in a liquid-tight manner to maintain sterile conditions within the device 1. The cabinet 10 can be replaced by any other suitable means that allows for the prevention of contaminants from entering the apparatus. This is particularly important in the preparation of the nutritional compositions according to the invention, since they are intended to feed infants. The interior of the device 1 is typically (or contains) a container 2, a delivery device 3, and a funnel-shaped collector 12. Thereby, only the opening to the inside of the container 2 passes through the mouth portion 15 of the funnel-shaped collector 12, which is sealed by a valve (not shown) which is also controlled by the controller 7.
此外，消毒構件(未繪示)可配置在機殼10背後以例如在機殼10已打開用於***容器2後獲得及維持無菌條件。此消毒構件係臭氧源及/或至少一UV光源。在設備內維持無菌條件在製備根據本發明之營養組合物時特別重要，此係因為其等旨在餵飼嬰兒。 Additionally, a sterilization member (not shown) can be disposed behind the housing 10 to obtain and maintain sterile conditions, for example, after the housing 10 has been opened for insertion into the container 2. The disinfecting member is an ozone source and/or at least one UV light source. Maintaining sterile conditions within the device is particularly important in preparing the nutritional compositions according to the present invention because they are intended to feed the infant.
嬰兒配方奶粉係僅設計以給予嬰兒類似於人類母乳之營養膳食之營養組合物。嬰兒配方奶粉可為給予嬰兒之唯一食物或給予作為固體食物之補充。 Infant formula is a nutritional composition designed to give a baby a nutritional diet similar to human breast milk. Infant formula can be the only food given to the infant or supplemented as a solid food.
亦可被稱作補充組合物之強化組合物係旨在給予嬰兒作為奶諸如人類母乳或動物奶，例如牛奶之補充或作為市場上可購得之習知嬰兒配方奶粉之補充之組合物。 The reinforced composition, which may also be referred to as a supplemental composition, is intended to be administered to an infant as a supplement to milk such as human breast milk or animal milk, such as milk supplements or as a supplement to conventional infant formulas commercially available.
在判定將輸送至特定嬰兒之營養組合物之原料成分量時，嬰兒將攝取之奶，例如母親之母乳可針對不同養分含量，尤其蛋白質及脂肪進行分析，隨後將添加至奶之原料成分量被判定為奶中之實際養分含量及嬰兒之所要養分含量之間之差異。 In determining the amount of the raw ingredient component of the nutritional composition to be delivered to a particular infant, the milk that the infant will ingest, such as the mother's breast milk, can be analyzed for different nutrient contents, particularly protein and fat, and then the amount of raw ingredient added to the milk is Determine the difference between the actual nutrient content in the milk and the nutrient content of the infant.
因此，設備可進一步包括或存取用於分析奶中之養分量之奶分析器或經調適以接收人類母乳中養分量之值且其中設備經調適以基於來自代表將輸送之一或多個原料成分及奶中之實際養分之來自使用者之輸入判定將輸送之原料成分量。此外，奶分析器可有利地用於分析由設備製備之組合物。 Accordingly, the apparatus can further include or access a milk analyzer for analyzing the nutrient content in the milk or adapted to receive a value of the nutrient component of the human breast milk and wherein the device is adapted to deliver one or more materials based on the representative from the representative The actual nutrient content of the ingredients and milk is determined by the input from the user to determine the amount of raw material component to be delivered. Furthermore, the milk analyzer can advantageously be used to analyze compositions prepared by the device.
可能重要之另一問題係將製作之組合物可由政府規定或以其他方式規定以滿足特定營養限制。為瞭解決此等問題，設備可進一步包括或存取資料庫，該資料庫儲存嬰兒養分之推薦最大及/或最小攝取值之此法定資料。在輸送原料成分時，此資料庫被查找看實際輸送是否將導致違反任何此法定資料，且在違反法定資料之情况中，此將在輸送前傳達給使用者。 Another problem that may be important is that the composition to be made can be prescribed by the government or otherwise specified to meet specific nutritional constraints. To address these issues, the device may further include or access a database that stores the statutory maximum recommended and/or minimum ingested value of the infant's nutrient. When the raw material ingredients are delivered, this database is looked up to see if the actual delivery will result in a violation of any of this statutory material, and in the event of a violation of statutory data, this will be communicated to the user prior to delivery.
此外，一些原料成分可被視作在存在於相同組合物中時衝突或不相容且此問題可類似於上述監管者問題藉由查詢儲存有關此等衝突之資料之資料庫而處理。 In addition, some of the ingredients may be considered to be conflicting or incompatible when present in the same composition and this problem may be handled by a database that stores information about such conflicts by querying the above-mentioned regulatory issues.
有時，先前餵飼之組合物之效應可能有利地影響原料成分之實際輸送之判定。此可舉例而言，為其已表明嬰兒對一或多個原料成分產生負面或正面反應之情况。為了在原料成分之實際輸送之判定中考慮此問題，設備可進一步包括或存取資料庫，該資料庫儲存先前用由設備產生之組合物或普通組合物餵食之嬰兒之反應之資料。此外，特定嬰兒例如前兩天、三天或四天前之攝取量亦可儲存及用於判定原料成分之實際輸送。舉例而言，若先前攝取量已產生負面反應且導致負面反應之該(等)原料成分或數量被識別，則被計量原料成分被調節以避免此負面反應。 Sometimes, the effect of a previously fed composition may beneficially affect the determination of the actual delivery of the ingredients. This may, for example, be the case where the infant has been shown to have a negative or positive response to one or more of the ingredients of the ingredients. In order to take this into account in the determination of the actual delivery of the raw ingredients, the device may further include or access a database that stores information about the reaction of the infant previously fed with the device-derived composition or common composition. In addition, the intake of a particular infant, such as the first two days, three days, or four days ago, can also be stored and used to determine the actual delivery of the ingredients. For example, if the previously ingested amount has produced a negative reaction and the (or) raw material component or amount that caused the negative reaction is identified, the metered raw material component is adjusted to avoid this negative reaction.
如上所述，本發明係關於一種用於提供被計量原料成分之設備及亦係關於一種製備將餵飼嬰兒之組合物之方法。方法通常在電腦中實施且可具有提供組合物所需之原料成分量作為輸出。本發明亦係關於該方法，其中根據本發明之設備1用於製備組合物。 As indicated above, the present invention relates to an apparatus for providing a metered ingredient component and to a method of preparing a composition for feeding an infant. The method is typically carried out in a computer and may have an amount of the raw ingredient component required to provide the composition as an output. The invention is also directed to the method wherein the apparatus 1 according to the invention is used to prepare a composition.
製備如在本發明之設備中之自動化程度可更大或更小或製備可留給適當之經培訓人員。組合物針對特定嬰兒定製且方法通常從養分之推薦攝取值及/或特定嬰兒之健康參數判定將存在於組合物中之個別原料成分量。組合物此外可針對特定餵飼，諸如腸道餵飼定製。 The degree of automation as prepared in the apparatus of the present invention may be greater or lesser or the preparation may be left to the appropriate trainee. The composition is tailored to a particular infant and the method typically determines the amount of individual ingredient ingredients that will be present in the composition from the recommended intake value of the nutrient and/or the health parameters of the particular infant. The composition may additionally be tailored to specific feedings, such as intestinal feeding.
本發明之另一目標係將根據本發明之設備1用於製備將餵飼嬰兒之營養組合物，其中該組合物針對嬰兒之特定需求定製。設備1將能夠從養分之推薦攝取值及/或特定嬰兒之健康參數判定將存在於組合物中之個別原料成分量。嬰兒可為足月兒、早產兒、低出生體重嬰兒、小於孕齡(SGA)嬰兒或學步幼兒。 Another object of the invention is to use the device 1 according to the invention for the preparation of a nutritional composition to be fed to an infant, wherein the composition is tailored to the specific needs of the infant. The device 1 will be able to determine the amount of individual ingredient ingredients that will be present in the composition from the recommended intake value of the nutrient and/or the health parameters of the particular infant. Infants can be term infants, premature infants, low birth weight infants, gestational age (SGA) infants or toddlers.
在特定有利實施例中，嬰兒係早產兒或低出生體重嬰兒。 In a particularly advantageous embodiment, the infant is a premature or low birth weight infant.
在特定實施例中，嬰兒可為具有更高之能量需求之嬰兒，舉例而言，生病(諸如心臟病)的嬰兒或對於孕齡較小之嬰兒。 In particular embodiments, the infant may be an infant with a higher energy requirement, for example, an infant who is ill (such as a heart disease) or a baby who is gestational age.
應瞭解熟習此項技術者瞭解本文所述之目前較佳實施例之各種變化及修改。可進行此等變化及修改而不脫離本發明之精神及範疇且不減少其附帶優點。因此，此等變化及修改旨在涵蓋於附屬申請專利範圍中。 It will be appreciated that those skilled in the art will recognize various changes and modifications of the presently preferred embodiments described herein. These changes and modifications can be made without departing from the spirit and scope of the invention and without the attendant advantages thereof. Accordingly, such changes and modifications are intended to be included within the scope of the appended claims.
舉例而言，類似設備可用於將營養組合物餵飼幼兒，例如2歲以上或3歲以上或5歲以上或更大的幼兒。 For example, a similar device can be used to feed a nutritional composition to a child, such as a child over 2 years old or older than 3 years old or older.
1‧‧‧設備 1‧‧‧ Equipment
2‧‧‧容器 2‧‧‧ Container
3‧‧‧輸送裝置 3‧‧‧Conveyor
4‧‧‧貯器 4‧‧‧Storage
5‧‧‧計量裝置 5‧‧‧Measuring device
6‧‧‧資料庫 6‧‧‧Database
7‧‧‧控制器 7‧‧‧ Controller
10‧‧‧機殼 10‧‧‧Chassis
11‧‧‧容座 11‧‧‧ 容座
12‧‧‧漏斗狀收集器 12‧‧‧Funnel Collector
13‧‧‧管道 13‧‧‧ Pipes
14‧‧‧輸入構件 14‧‧‧ Input components
15‧‧‧口部 15‧‧‧ mouth
Claims (23)
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| EP12016341 | 2012-04-05 |
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| TW201350069A true TW201350069A (en) | 2013-12-16 |
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| TW102112425A TW201350069A (en) | 2012-04-05 | 2013-04-08 | Apparatus and method for providing metered amounts of ingredient, especially for a tailored nutrition to infants |
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Cited By (1)
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| WO2019140432A1 (en) * | 2018-01-15 | 2019-07-18 | Hygieia Health Co., Limited | Systems, methods, compositions and devices for personalized nutrition formulation and delivery system |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2019140432A1 (en) * | 2018-01-15 | 2019-07-18 | Hygieia Health Co., Limited | Systems, methods, compositions and devices for personalized nutrition formulation and delivery system |
| CN112236120A (en) * | 2018-01-15 | 2021-01-15 | 定制脚本有限公司 | Systems, methods, compositions, and devices for personalized nutritional formulas and delivery systems |
| EP3740183A4 (en) * | 2018-01-15 | 2021-09-29 | Hygieia Health Co., Limited | Systems, methods, compositions and devices for personalized nutrition formulation and delivery system |
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