201242603 六、贫明說明： 【發明所屬之技術領域】 本發明係指一種具有降血糖功效綠藻，特別是指一種 小球藻乾製而成之機能性食品，具有達到降血糖的功效。 【先前技術】 技術論述係用以對促進對本發明之了解，而不意欲作為先前 f 常伴隨著副仙，本著「藥食_、」的概念， ^文獻^某些天然食材如蘋果、葡萄、可可、人篆、肉桂、白 :酵夕辛聽/ΐΓΓ旨肪酸等成分，藉由降低®㈣由基、α姻糖 f酵素⑻Pha，lucosldase)、活化過氧化體增殖 織葡萄醋吸收等的方式來調控血糖，使序亂的代謝過程正常化， 有鑑於以綠藻在糖尿病防治的功效上，尚無明確的證據，因 此本試驗依_辛基宣額精神及__法令的規定，執行此臨 床試驗。 【發明内容】 為了解決上錢前技術之問題，本發明提供—種 加以乾製而成’為具有前述糖尿病防治功效之機能性食品， 邊製品可為保健食品及/或醫藥組成物。 乂 口 口 本發明證實綠藻中的不飽和脂肪酸如亞麻油酸、次亞麻油酸為 201242603 p驟的活化劑，可使PPAR活化。PPAR為核受體基因家族，可 調節許多基_表現，包含血糖濃度、血脂、域與發炎反應等。 在血糖濃度卿方面，PPAR可調控肌肉組織之㈣糖吸收、肝酶 合成、降低發炎激素分泌、提高葡萄轉運蛋自 帥表現、降低姨島素抗性等，達到抗糖尿病、抗動脈粥狀 硬化或其他發炎相齡症。因此在賴降血糖安定性試驗中將亞麻 油酸、次亞麻油_為品管指標，其中亞麻油酸的含量約15_2 9%、 次亞麻油酸的含量約為1.2-1.9%。 藻。基於上敍其他目的’本發明之目的在於提供—種降血糖之綠 本發明之目的在於透過第二型糖尿病患者的臨床試驗，來直接 驗證綠藻對於糖尿病之預防及/或治療之綠藻。 本發明之另。目的在於觀察服麟驗是否有不㈣副作用。 本發明之另-目的在於經由σ服葡萄糖實驗了解是綠萍作用 可能機轉。 又」本發明之另—目的在於提供包含將、賴或其醫藥學 上可接文之竹生物投與有此需要之個體。 /、 【實施方式】 —為充分瞭解本發明之目的、特徵及功效，_由下述具體 二ίίΐ:斤附之圖式，對本發明做一詳細說明；下較佳 ΐ請專二_本發明之技術内容，並不用以限制本發明之 201242603 材料興万法 關於降血糖之綠藻，特別是指一種由小球藻(chi〇她 SGrOkmmna) ’將其乾製成綠藻粉。 試驗方法： 1. 本實驗共收集42位第二型糖尿病的患者，發病時間皆已超過一 年’以電腦亂數隨機分配成二組。以雙盲的方式，一組(個案數 2〇)食用安慰劑玉米澱粉350mg/cap(施ap/日），另一組食用綠藻 (個案數22) 35〇mg/cap(2〇cap/日）’分別進行三個月評估服用 綠藻後對於血糖、血脂肪及體脂肪等與新陳代謝有關的指標效 果。病人之平均年齡為58.丨士 8·8歲，男性有乃人，女性有 人。ΒΜΙ在25.4±3.8kg/m2之間，他們都服用兩種以下口服種 藥物（包含兩種）或是目前尚在飲食控制的病人，其一般的身體 數據皆在表一中顯示。所有的個案在實驗期間與實驗結束時，均 而接文身體檢查、空腹抽血採樣以及口服葡萄糖耐量實驗（沉以 glucose tolerance test)以評估綠藻的療效。 2. 口服葡萄糖耐量實驗（oral glucose t〇〗erance test，〇GTT): 以75克葡萄糖給予病人於五分鐘之内飲用。然後於下列時間點 抽血檢驗血糖及膜島素：〇 ’ 5，1〇，20，30，45，60，80，1〇〇， ’ 150，180 分鐘。 孓、、先°十方法·治療前後的比較’皆以pairedt-test來比較。兩組之 間的差異性則用t test。所有的數據皆以me an 士 SE來表示。 201242603 4.本計劃依赫爾辛基宣言的精神及國内相關法令的規定與通過耕 莘醫院人體實驗委員會的審查，所有的受測者皆有簽署人體實驗 同意書。 6 201242603 箱木： 一）綠藻組與安慰劑組12调# 較： 遇貫驗前後口服葡萄糖耐量實驗之比 f 一為綠藻組與安慰劑組12週實驗 耐虿貫驗之血漿中詰钱 服1]萄糖 驗過程中，對照圖1&安1檢卞測數據。在口服葡萄糖耐量實 呈現下降域，料切：^：^之錄的變化雖 _ , 咬、尤冲學上的意義，而對昭圖说 滅組之血_化只有在 L圖lb綠 二（〇为鐘）時有明顯的下降。 表二為由綠藻組與安慰劑组12週實 =:驗之血_島素檢測數據。對照3 組姨島素账雖呈現上精態，唯其未魏牌^ 上的意義。而綠藻組(Fig.2b )之 耐量實驗末期⑽分鐘）有明_下降=D民葡萄糖 7 201242603 -s^auuBJ-o-asoun-leJO^UIJnp SV^UBlpasoDn-BES-J i 6-+6.9^: 0ΊΪ τ-ςζζ-6τ6Ό0ε-6^8ζιε-ΟΙ+ετιε-01+0.寸 63 I 8 + 8_8+·卜 03-9+-/. 91-9+1-寸1 寸.9 + 87 寸 I Juyv '2|4|0.6寸3 g'-IF'-I^N 51 T9.06Z'·二 ZFQ.gQg sl+ose'-二？'-S3^6+^993'-6IF07,eN 1.6 + 5131·1001411·寸'-2 + 6.81^口+1·1^'0一uJO'-g. , ««-16 •9lT9.eoz 9-1+--.卜寸 3 ,-31^-/23-21+8-83 ΓΝιτ 寸ε°°3-11 + 1.99^--+1.6 寸Z 6.6 + 9.813-6+-卜61-8-^-651-8 + 6.1 寸一·卜T-Z 寸 I Juyv Γ'-+σ1001-IOO.9'--^0.6SZ'-91 七Γ€6Ζ1 '-+0.06Ζ Ο.'-Τ'-Ζ,ΒΖ 6.11七'-9/,1 ο.ι2ι4ι£'-·9ζ £.6141寸 X£Z'•^ZP'-SN 8.9^/..41'-9 + 3.卜'"3J0JSlm 0q93-'d~^ ^~~ ^ ^ ^ ^ ^ ^ ^ ^ i 5 -^auueJ-o'-asoun-IBJO^UIJnp sa^uelp-lnsuJBES-J 1 Placebo 25.7 ±2.8 29.6 ±5.8 Chlorella 34.4 土 4.7 21.9 土 2.7* 150 36.6 ±4.6 40.7 ±7.6 36.2 ±4.4 30.2 土 3.0 § 47.0 ±8_5 55.5 土 11.1 39.2 ±5.3 38.0 土 5.0 o 48·4±7.0 50·6 ± 9.6 43.3 ±5.7 42.3 土 5.2 § 46.9 土 6.9 54.2 土 9.9 43.1 ±5.7 48.0 土 5.7 40,5 ±5.7 42.1 ±7.4 41.3 ±4.8 36.8 ±33 *n 35.7 ±5.7 40.0 土 6.5 33.2 ±4.4 29.4土 2.4 32.9 土 7.2 31.1 士 5.2 26.9 土 3.0 25.3 ±2.4 26.8 土 3·5 23.1 ±3.0 24.1 士 2.4 23.3士 3.0 o 18.5 ±2.3 22.4 士 5.1 20.8 ±3.2 17.0± 1.8 15.1 ±2.1 12.1 ±2.1 14.0 ± 1.8 13.2 士 1.8 〇 11.7± 1.4 10.3 土 2.0 11.2 士 1.7 10·8± 1.4 Before After Before After iuuuls3buJ0J3q2puJBdlu03 们°°>^* 201242603 ㈡綠藻組與絲敝12週實财後身贿查與空腹抽血 數據之比較： 從表三、® 週實 驗前後其空腹抽血與各項生化檢測數據與曲線:顯示出來 服用綠藻組的受試者的體重、糖化血色素（HbAlc)、空腹 血糖（FPG)皆成有意義的下降。而這項目並未在服用安慰 劑的這組發現有下降的情況。 表四、綠藻組與安慰劑組12週實驗前後其空腹抽血 與各項生化彳欢測數據的差異:在兩組比較下，實驗前後糖化 血色素的下降在綠藻組比安慰劑組來的更明顯。 表三：安慰劑組與綠藻組分別在實驗前與實驗後的身 體檢查與空腹抽血數據比較： _ 安慰劑組(n=20) 綠藻組(η=22^ ' ~~ 體重（kg) BMI 腰圍（cm) 糖化血紅素（％) 空腹血糖（mg/dl) _實驗前 實驗後 Ρ值 實驗前 ~~~ 64.2 ±2.40 63.6 ±2.41 NS 64.2 ±2.77 63.2 ±275~~~ 25.5 ±0.80 25.3 ±0.76 NS 25.0 ±0.75 24.6 ±0.75 Ns 89.8 ±1.88 88.7 ±1.81 〇.〇〇9 88.3 ± 1.85 87.3 ±1.79 Ns 7.6 士0.18 7.8 ±0.24 NS 8.0 ±0.25 7.5 ±0.14 0〇〇9 157.2 ±6.52 142.5 ± 7.42 0.036 162.2 ±7.14 142.9 ±6.38 〇 〇〇,201242603 VI. Description of the poor: [Technical field to which the invention belongs] The present invention refers to a green algae having a hypoglycemic effect, in particular, a functional food made of dried chlorella, which has the effect of lowering blood sugar. [Prior Art] The technical discussion is used to promote the understanding of the present invention, and is not intended to be accompanied by the concept of "medicine food," in the previous article. ^Documents^ Certain natural ingredients such as apples, grapes , cocoa, amaranth, cinnamon, white: the ingredients of the yeast yinxin / yin fat, by reducing the (4) from the base, the alpha sugar f enzyme (8) Pha, lucosldase), the activated peroxisome proliferation vinegar vinegar absorption, etc. The way to regulate blood sugar, normalize the metabolic process of disorder, in view of the efficacy of green algae in the prevention and treatment of diabetes, there is no clear evidence, so this test is based on the spirit of _ Xinji Xuanyuan and __ decree, Perform this clinical trial. SUMMARY OF THE INVENTION In order to solve the problem of the prior art, the present invention provides a functional food having the aforementioned diabetes prevention and control function, and the side product may be a health food and/or a pharmaceutical composition.乂 Oral The present invention demonstrates that unsaturated fatty acids such as linoleic acid and linoleic acid in green algae are activators of 201242603 p, which activate PPAR. PPAR is a nuclear receptor gene family that regulates many basal expressions, including blood glucose levels, blood lipids, domains, and inflammatory responses. In terms of blood glucose concentration, PPAR can regulate muscle tissue (4) sugar absorption, liver enzyme synthesis, reduce inflammatory hormone secretion, improve grape transport egg self-satisfaction performance, reduce 姨 素 resistance, etc., to achieve anti-diabetes, anti-atherosclerosis Or other inflammatory age. Therefore, in the blood sugar stability test, linoleic acid and linseed oil are the quality control indicators, wherein the content of linoleic acid is about 15-2 9%, and the content of linoleic acid is about 1.2-1.9%. Algae. Other purposes of the present invention The purpose of the present invention is to provide a hypoglycemic green. The purpose of the present invention is to directly verify the green algae for the prevention and/or treatment of diabetes by the green algae through clinical trials of patients with type 2 diabetes. Another aspect of the invention. The purpose is to observe whether there is no (four) side effects. Another object of the present invention is to understand through the sigma glucose experiment that it is a possible action. Further, another object of the present invention is to provide an individual having a need to include, or to administer, a medicinally acceptable bamboo organism. /, [Embodiment] - In order to fully understand the object, features and effects of the present invention, the present invention will be described in detail by the following specific figures: the preferred embodiment of the present invention. The technical content is not intended to limit the 201242603 material of the present invention. The green algae for lowering blood sugar, especially one is made of green algae powder by chlorella (chi〇 her SGrOkmmna). Test Methods: 1. A total of 42 patients with type 2 diabetes were collected in this experiment, and the onset time was more than one year. In a double-blind manner, one group (2 cases) had placebo corn starch 350mg/cap (apple a/day) and the other group consumed green algae (case 22) 35〇mg/cap (2〇cap/ Day) 'Evaluate the effects of metabolism related to metabolism such as blood sugar, blood fat and body fat after taking green algae for three months. The average age of the patients is 58. Gentleman 8·8 years old, male is male and female is human. ΒΜΙ between 25.4 ± 3.8 kg / m2, they are taking two or more oral drugs (including two) or patients currently in diet control, the general body data are shown in Table 1. All cases were evaluated during the experimental period and at the end of the experiment, and physical examination, fasting blood sampling, and oral glucose tolerance test were performed to evaluate the efficacy of green algae. 2. Oral glucose tolerance test (oral glucose t〇 erance test, 〇GTT): The patient is given a dose of 75 grams of glucose within five minutes. Blood and membrane insulin were then taken at the following time points: ’ ‘ 5,1 〇, 20, 30, 45, 60, 80, 1 〇〇, ’ 150, 180 minutes.孓,, first, ten methods, comparison before and after treatment, are compared by pairedt-test. The difference between the two groups is t test. All data is expressed in me an SE. 201242603 4. This plan is based on the spirit of the Helsinki Declaration and the relevant domestic laws and regulations and the review of the Human Body Experimental Committee of the Gourd Hospital. All subjects have signed consents for human experiments. 6 201242603 Box wood: a) Green algae group and placebo group 12 tune # Comparison: The ratio of oral glucose tolerance test before and after the test was f. The plasma sputum was tested for 12 weeks in the green algae group and the placebo group. In the process of money service 1], check the data of Figure 1 & In the oral glucose tolerance, there is a decline in the field. The cut: ^:^ The change in the record is _, bite, and the meaning of the scholastic, but the blood of the group is shown in the L map lb green two ( There is a significant drop in the time when it is a bell. Table 2 shows the data from the green algae group and the placebo group for 12 weeks =: blood test. Compared with the three groups of 姨岛素 accounts, although they are in the fine state, they only have the meaning of Wei. In the end of the tolerance test (10) minutes of the green algae group (Fig. 2b), there is a clear_decline = D-dose glucose 7 201242603 -s^auuBJ-o-asoun-leJO^UIJnp SV^UBlpasoDn-BES-J i 6-+6.9^ : 0ΊΪ τ-ςζζ-6τ6Ό0ε-6^8ζιε-ΟΙ+ετιε-01+0.inch 63 I 8 + 8_8+·卜03-9+-/. 91-9+1-inch 1 inch.9 + 87 inch I Juyv '2|4|0.6 inch 3 g'-IF'-I^N 51 T9.06Z'· two ZFQ.gQg sl+ose'-two? '-S3^6+^993'-6IF07,eN 1.6 + 5131·1001411·inch'-2 + 6.81^口+1·1^'0一uJO'-g. , ««-16 •9lT9.eoz 9 -1+--.卜寸3 ,-31^-/23-21+8-83 ΓΝιτ inch ε°°3-11 + 1.99^--+1.6 inch Z 6.6 + 9.813-6+-b 61-8 -^-651-8 + 6.1 inch one·b TZ inch I Juyv Γ'-+σ1001-IOO.9'--^0.6SZ'-91 Γ€6Ζ1 '-+0.06Ζ Ο.'-Τ'- Ζ,ΒΖ 6.11七'-9/,1 ο.ι2ι4ι£'-·9ζ £.6141 inch X£Z'•^ZP'-SN 8.9^/..41'-9 + 3.卜'"3J0JSlm 0q93-'d~^ ^~~ ^ ^ ^ ^ ^ ^ ^ ^ i 5 -^auueJ-o'-asoun-IBJO^UIJnp sa^uelp-lnsuJBES-J 1 Placebo 25.7 ±2.8 29.6 ±5.8 Chlorella 34.4 Soil 4.7 21.9 Soil 2.7* 150 36.6 ±4.6 40.7 ±7.6 36.2 ±4.4 30.2 Soil 3.0 § 47.0 ±8_5 55.5 Soil 11.1 39.2 ±5.3 38.0 Soil 5.0 o 48·4±7.0 50·6 ± 9.6 43.3 ±5.7 42.3 Soil 5.2 § 46.9 Earth 6.9 54.2 Soil 9.9 43.1 ± 5.7 48.0 Soil 5.7 40,5 ± 5.7 42.1 ± 7.4 41.3 ± 4.8 36.8 ± 33 * n 35.7 ± 5.7 40.0 Soil 6.5 33.2 ± 4.4 29.4 Soil 2.4 32.9 Soil 7.2 31.1 ± 5.2 26.9 Soil 3.0 25.3 ± 2.4 26.8 Soil 3·5 23.1 ±3.0 24.1 ± 2.4 23.3 ± 3.0 o 18.5 ± 2.3 22.4 ± 5.1 20.8 ±3.2 17.0±1.8 15.1 ±2.1 12.1 ±2.1 14.0 ± 1.8 13.2 ±1.8 〇11.7± 1.4 10.3 Earth 2.0 11.2 士1.7 10·8± 1.4 Before After Before After iuuuls3buJ0J3q2puJBdlu03 ̄°°>^* 201242603 (II) Green algae group and Comparison of silkworms' 12-week post-harvest bribery and fasting blood draw data: From the table 3 and the ® week before and after the experiment, the fasting blood and various biochemical test data and curves: the subjects who showed the green algae group Body weight, glycated hemoglobin (HbAlc), and fasting blood glucose (FPG) all have a meaningful decline. This project did not show a decline in the group taking placebo. Table 4: Differences between fasting blood sampling and various biochemical licking data before and after the 12-week experiment in the green algae group and the placebo group: In the two groups, the decrease in glycated hemoglobin before and after the experiment was in the green algae group compared with the placebo group. More obvious. Table 3: Comparison of physical examination and fasting blood sampling before and after the experiment between the placebo group and the green algae group: _ placebo group (n=20) green algae group (η=22^ ' ~~ weight (kg BMI Waist circumference (cm) Glycated hemoglobin (%) Fasting blood glucose (mg/dl) _ Pre-experimental experiment Ρ value before experiment ~~~ 64.2 ±2.40 63.6 ±2.41 NS 64.2 ±2.77 63.2 ±275~~~ 25.5 ±0.80 25.3 ±0.76 NS 25.0 ±0.75 24.6 ±0.75 Ns 89.8 ±1.88 88.7 ±1.81 〇.〇〇9 88.3 ± 1.85 87.3 ±1.79 Ns 7.6 ± 0.18 7.8 ±0.24 NS 8.0 ±0.25 7.5 ±0.14 0〇〇9 157.2 ±6.52 142.5 ± 7.42 0.036 162.2 ±7.14 142.9 ±6.38 〇〇〇,
Ns ~~~—— 201242603 表四：安慰劑組與綠藻組分別在實驗前後的身體檢查與空 腹抽血數據差（實驗前減實驗後）比較：Ns ~~~—— 201242603 Table 4: Comparison between the physical examination of the placebo group and the green algae group before and after the experiment and the data of the empty blood draw (after the experiment minus the experiment):
安慰劑組 綠藻組 P值 體重（kg) 0.57 ±0.36 1.01 ±0.36 NS BMI (kg/m2) 0_24±0.14 0.39 ±0.14 NS 腰圍（cm) 1.08 ±0.37 1.00 ±0.50 .NS 糖化血紅素（％) -0.25 ±0.13 0.52±0.18 0.001 空腹血糠（mg/dl) 14.75 ±6.52 19.32 士 4_95 NS NS :無統計意義。 201242603 討論： 1.血糖的影響： 本次實驗證實了綠藻降血糖的效果。此一效果可由糖化 血紅素圖3及圖4空腹血糖的下降獲得證實。第二型糖尿 病患者在服用綠藻12週後，糖化血紅素方面約下降了 0.5% ’而平均空腹血糖則約下降了 2〇mg/di。而服用賴 的患者與只有服用安慰劑的患者在12週實驗後，各別去比 車又糖化血紅素下降的幅度（diffe_e)，發現顧安慰劑組 上升了約0.2/〇’在統计學上明顯比綠藻組（約下降ο·;% ) 來的乂。這樣的結果更是證實了、賴本身在降血糖方面的 功效。在健康食品巾’這樣⑽說是相#令人滿意的效果。 —至於降血糖的機轉，在之前的前言中已提到，透過動物 實驗及少數的人體試驗發現，綠藻主要可以改善肝臟與肌 肉的葡萄糖吸收能力，達到降血糖的效果。本實驗中糖尿 病患者的糖化血紅素與空腹血糖下降已經獲得證實。另 外’部分的動物實驗告訴我們，由於服用綠藻也會透過 PARA-gamma受體的活化、增加細胞中第4型葡^糖運送 蛋白的表現、改贿島素訊息傳遞麵等方絲增進胰島 素的靈敏度，促進血糖下降。本實驗的口服葡萄糖耐量實 驗中’已經間接證實了這-點。服用綠藻組的糖尿病患者， 在服用綠藻前與用綠藻12週後分別各進行了一次口服葡 萄糖财量實驗，軸在於π服葡雜耐量實驗中，沒有 201242603 看到血糖的下降（空腹點除外），然而可贿現服用綠藻 u週後的胰島素鋪降低，這綱了這些服用綠藻的患者 可以用更少的胰島素來維持一定的血糖值。換言之，^些 服用綠SS的患者，㈣素的錄度6轉到鴨的改善， 胰島素的作用能力比服用綠藻前更好。 據上所述，綠藻在第二型糖尿病的患者可以達到降低 =腹血糖膽化血紅素尿酸值的树。其作關轉可能是 :胰島素敏感度之改善。另外，病人並無任何副作用的發 【圖式簡單說明】 圖la，本發明為在口服葡萄糖耐量實驗過程 中，安慰劑之血糖的變化顯示圖表。 綠藻 f本發明在σ服葡萄糖耐量實驗過程中， 、、且之血糖的變化顯示圖表。 圖2b係太旅瓜研句I雙化顯示圖肩 去il、，1月在口服葡萄糖耐量實驗之血漿中 ，檢測數據，綠藻組之胰島‘ 圖3係本發明較祛每 殳亿』不圖表0 圖4係本發明較佳 紅素變化顯示圖表。 圖表知她佳^之空腹血糖的下降變化顯示 【主要元件符號說明】 二發數胰島Placebo group Green algae group P value body weight (kg) 0.57 ± 0.36 1.01 ± 0.36 NS BMI (kg / m2) 0_24 ± 0.14 0.39 ± 0.14 NS waist circumference (cm) 1.08 ± 0.37 1.00 ± 0.50. NS glycated hemoglobin (%) -0.25 ± 0.13 0.52 ± 0.18 0.001 Fasting blood stasis (mg/dl) 14.75 ± 6.52 19.32 ± 4_95 NS NS : Not statistically significant. 201242603 Discussion: 1. Effects of blood sugar: This experiment confirmed the effect of green algae on lowering blood sugar. This effect can be confirmed by the decrease in fasting blood glucose in Figure 3 and Figure 4 of glycated hemoglobin. In the second type of diabetic patients, after taking Chlorella for 12 weeks, the glycated hemoglobin decreased by about 0.5%, while the average fasting blood glucose decreased by about 2 mg/di. The patients who took Lai and the patients who took only placebo after the 12-week experiment, each went to the rate of glycosylated hemoglobin (diffe_e), and found that the placebo group increased by about 0.2 / 〇 'in statistics The sputum is significantly higher than the green algae group (about ο·;%). This result confirms the efficacy of Lai itself in lowering blood sugar. In the case of a healthy food towel, (10) is said to be a satisfactory result. As for the mechanism of blood sugar lowering, it has been mentioned in the previous preface that through animal experiments and a few human experiments, it is found that green algae can mainly improve the glucose absorption capacity of liver and muscle, and achieve the effect of lowering blood sugar. The decline in glycated hemoglobin and fasting blood glucose in patients with diabetes in this experiment has been confirmed. In addition, some animal experiments tell us that the use of green algae also promotes insulin through the activation of PARA-gamma receptors, increases the expression of type 4 glucose transporters in cells, and changes the message surface of the bricans. The sensitivity of the blood sugar is reduced. This point has been indirectly confirmed in the oral glucose tolerance test of this experiment. In the diabetic patients who took the green algae group, they took an oral glucose test before and after using the green algae for 12 weeks. The axis was in the π-storage tolerance test, and there was no 201242603 to see the drop in blood glucose (fasting Except for the point), however, the insulin shop after the week of taking the green algae is reduced, which allows the patients who take the green algae to maintain a certain blood sugar level with less insulin. In other words, in some patients taking green SS, the recording of (4) is improved to the duck, and the ability of insulin is better than before taking green algae. According to the above, the green algae in patients with type 2 diabetes can reach a tree that reduces the uric acid value of bilirubin hemoglobin. Its turnaround may be: an improvement in insulin sensitivity. In addition, the patient does not have any side effects. [Simplified illustration] Fig. la, the present invention shows a graph showing changes in blood glucose of a placebo during an oral glucose tolerance test. Chlorella f The present invention shows a graph of changes in blood glucose during the σ-based glucose tolerance test. Figure 2b is a model of the singularity of the singularity of the singularity of the spleen, and in the plasma of the oral glucose tolerance test in January, the test data, the islet of the green algae group. Figure 3 is a comparison of the present invention. Figure 0 Figure 4 is a graph showing a preferred red pigment change of the present invention. The chart shows that the change in fasting blood glucose of her good ^ shows [the main component symbol description]